psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F21	R:R:L11	6.09	No	No	8	2	8
2	R:R:L11	R:R:R270	3.64	No	No	8	8	1
3	R:R:D14	R:R:E12	19.49	No	No	0	5	5
4	R:R:C266	R:R:I13	6.55	No	No	0	7	3
5	R:R:D14	R:R:N171	10.77	No	No	0	5	1
6	R:R:K15	R:R:N171	8.39	No	No	0	3	1
7	R:R:K16	R:R:N17	9.79	No	No	0	4	5
8	R:R:N17	R:R:T263	8.77	No	No	0	5	3
9	R:R:C18	R:R:C183	7.28	No	No	0	9	1
10	R:R:C19	R:R:T263	3.38	No	No	0	4	3
11	R:R:C19	R:R:C266	7.28	No	No	0	4	7
12	R:R:C19	R:R:Y269	6.72	No	Yes	0	4	2
13	R:R:F21	R:R:R270	11.76	No	No	8	2	1
14	R:R:D273	R:R:F21	8.36	No	No	0	4	2
15	R:R:R22	R:R:R90	43.72	No	No	0	3	4
16	R:R:R22	R:R:W91	6	No	Yes	0	3	4
17	R:R:D23	R:R:L274	10.86	No	No	0	4	1
18	R:R:F25	R:R:V29	13.11	No	No	0	6	5
19	R:R:F25	R:R:L274	3.65	No	No	0	6	1
20	R:R:F25	R:R:I278	3.77	No	No	0	6	6
21	R:R:I26	R:R:L30	8.56	No	No	0	5	5
22	R:R:F277	R:R:I26	7.54	No	No	0	5	5
23	R:R:L30	R:R:Y87	4.69	No	Yes	0	5	6
24	R:R:P31	R:R:P32	5.84	Yes	No	0	6	5
25	R:R:P31	R:R:V88	3.53	Yes	No	0	6	3
26	R:R:E37	R:R:V33	4.28	No	No	0	7	5
27	R:R:L34	R:R:L80	4.15	Yes	No	0	8	8
28	R:R:L34	R:R:L83	5.54	Yes	No	6	8	6
29	R:R:L34	R:R:Y87	3.52	Yes	Yes	6	8	6
30	R:R:L34	R:R:Y284	4.69	Yes	Yes	6	8	7
31	R:R:G35	R:R:M84	3.49	No	No	0	5	7
32	R:R:F40	R:R:L36	3.65	No	No	0	6	4
33	R:R:E37	R:R:M285	6.77	No	Yes	0	7	5
34	R:R:F38	R:R:L80	7.31	No	No	0	7	8
35	R:R:F38	R:R:P81	7.22	No	No	0	7	8
36	R:R:F40	R:R:M288	3.73	No	No	0	6	8
37	R:R:G41	R:R:V287	3.68	No	No	0	8	8
38	R:R:G44	R:R:P291	4.06	No	No	0	7	9
39	R:R:N45	R:R:V70	5.91	Yes	No	1	9	8
40	R:R:D73	R:R:N45	12.12	Yes	Yes	1	9	9
41	R:R:I77	R:R:N45	4.25	No	Yes	0	6	9
42	R:R:N45	R:R:P291	3.26	Yes	No	0	9	9
43	R:R:N45	R:R:Y294	5.81	Yes	Yes	1	9	9
44	R:R:F305	R:R:L47	4.87	No	No	0	6	6
45	R:R:A48	R:R:Y294	4	No	Yes	0	9	9
46	R:R:F54	R:R:W50	12.03	No	No	0	4	4
47	R:R:F304	R:R:W50	4.01	Yes	No	0	4	4
48	R:R:F301	R:R:I51	12.56	No	No	0	9	7
49	R:R:F304	R:R:I51	13.82	Yes	No	0	4	7
50	R:R:F52	R:R:W59	4.01	Yes	No	1	7	6
51	R:R:F52	R:R:R63	5.34	Yes	No	0	7	7
52	R:R:F52	R:R:L66	4.87	Yes	No	1	7	8
53	R:R:F52	R:R:F67	4.29	Yes	Yes	1	7	6
54	R:R:F52	R:R:Y294	5.16	Yes	Yes	1	7	9
55	R:R:F301	R:R:F52	9.65	No	Yes	1	9	7
56	R:R:C53	R:R:F54	4.19	No	No	0	4	4
57	R:R:H55	R:R:L56	3.86	No	No	0	5	5
58	R:R:F304	R:R:H55	14.71	Yes	No	0	4	5
59	R:R:L56	R:R:R63	4.86	No	No	0	5	7
60	R:R:L56	R:R:S300	4.5	No	No	0	5	5
61	R:R:F67	R:R:W59	6.01	Yes	No	1	6	6
62	R:R:K60	R:R:N141	4.2	No	No	0	7	2
63	R:R:D124	R:R:S62	8.83	No	No	9	8	8
64	R:R:R128	R:R:S62	7.91	No	No	9	8	8
65	R:R:I64	R:R:N141	4.25	No	No	0	7	2
66	R:R:A144	R:R:I64	4.87	No	No	0	7	7
67	R:R:F65	R:R:V120	9.18	Yes	No	0	7	7
68	R:R:D124	R:R:F65	4.78	No	Yes	0	8	7
69	R:R:A144	R:R:F65	4.16	No	Yes	0	7	7
70	R:R:F65	R:R:I147	6.28	Yes	No	0	7	5
71	R:R:L66	R:R:V121	4.47	No	No	0	8	9
72	R:R:L66	R:R:Y294	5.86	No	Yes	1	8	9
73	R:R:F67	R:R:V70	5.24	Yes	No	1	6	8
74	R:R:F67	R:R:V71	3.93	Yes	No	0	6	6
75	R:R:F117	R:R:N68	20.54	No	No	3	8	9
76	R:R:N68	R:R:S148	8.94	No	No	0	9	8
77	R:R:N68	R:R:W152	9.04	No	Yes	3	9	9
78	R:R:D290	R:R:L69	6.79	Yes	No	1	9	9
79	R:R:L69	R:R:Y294	4.69	No	Yes	1	9	9
80	R:R:V70	R:R:Y294	6.31	No	Yes	1	8	9
81	R:R:D73	R:R:N286	5.39	Yes	Yes	1	9	9
82	R:R:D73	R:R:V287	10.22	Yes	No	0	9	8
83	R:R:D290	R:R:D73	11.98	Yes	Yes	1	9	9
84	R:R:D73	R:R:Y294	3.45	Yes	Yes	1	9	9
85	R:R:F74	R:R:I77	5.02	No	No	0	7	6
86	R:R:L75	R:R:M106	5.65	No	No	0	6	5
87	R:R:L76	R:R:L80	4.15	Yes	No	0	7	8
88	R:R:L76	R:R:N110	12.36	Yes	No	0	7	9
89	R:R:L76	R:R:Y284	8.21	Yes	Yes	0	7	7
90	R:R:L76	R:R:V287	5.96	Yes	No	0	7	8
91	R:R:C79	R:R:M103	4.86	No	No	0	6	5
92	R:R:C79	R:R:M106	4.86	No	No	0	6	5
93	R:R:F82	R:R:F95	10.72	No	Yes	0	6	7
94	R:R:L83	R:R:Y87	4.69	No	Yes	6	6	6
95	R:R:L83	R:R:Y284	5.86	No	Yes	6	6	7
96	R:R:D85	R:R:R89	14.29	No	No	0	4	4
97	R:R:D85	R:R:F95	8.36	No	Yes	0	4	7
98	R:R:N86	R:R:W91	3.39	No	Yes	0	5	4
99	R:R:N86	R:R:W93	10.17	No	Yes	0	5	9
100	R:R:W91	R:R:Y87	6.75	Yes	Yes	0	4	6
101	R:R:L176	R:R:W91	3.42	No	Yes	0	4	4
102	R:R:F277	R:R:W91	12.03	No	Yes	0	5	4
103	R:R:D92	R:R:K94	13.83	No	No	0	4	3
104	R:R:F95	R:R:W93	18.04	Yes	Yes	0	7	9
105	R:R:C100	R:R:W93	6.53	No	Yes	10	9	9
106	R:R:M103	R:R:W93	5.82	No	Yes	0	5	9
107	R:R:C177	R:R:W93	16.98	No	Yes	10	9	9
108	R:R:K94	R:R:N175	5.6	No	No	0	3	4
109	R:R:G96	R:R:P99	4.06	No	No	0	7	5
110	R:R:D97	R:R:R101	10.72	No	No	0	3	6
111	R:R:D97	R:R:K166	12.44	No	No	0	3	4
112	R:R:I98	R:R:P99	5.08	No	No	0	2	5
113	R:R:C100	R:R:M167	6.48	No	No	0	9	3
114	R:R:C100	R:R:C177	7.28	No	No	10	9	9
115	R:R:L107	R:R:M103	5.65	No	No	0	6	5
116	R:R:C177	R:R:L104	4.76	No	No	0	9	5
117	R:R:F105	R:R:M109	13.68	No	Yes	3	6	5
118	R:R:F105	R:R:T159	6.49	No	No	3	6	7
119	R:R:F105	R:R:L163	17.05	No	No	0	6	5
120	R:R:L107	R:R:Y284	4.69	No	Yes	0	6	7
121	R:R:A108	R:R:T159	3.36	No	No	0	4	7
122	R:R:M109	R:R:W152	4.65	Yes	Yes	3	5	9
123	R:R:I156	R:R:M109	5.83	No	Yes	0	4	5
124	R:R:M109	R:R:T159	4.52	Yes	No	3	5	7
125	R:R:N110	R:R:N286	12.26	No	Yes	0	9	9
126	R:R:Q112	R:R:R111	3.5	No	No	0	7	8
127	R:R:I115	R:R:R111	6.26	Yes	No	0	8	8
128	R:R:F193	R:R:R111	8.55	No	No	0	6	8
129	R:R:E196	R:R:Q112	8.92	No	No	0	5	7
130	R:R:G113	R:R:T155	3.64	No	No	0	7	7
131	R:R:N286	R:R:S114	7.45	Yes	No	0	9	9
132	R:R:I115	R:R:P200	3.39	Yes	No	0	8	9
133	R:R:F240	R:R:I115	7.54	Yes	Yes	5	9	8
134	R:R:F244	R:R:I115	13.82	No	Yes	5	8	8
135	R:R:I116	R:R:L151	4.28	No	No	0	5	7
136	R:R:F117	R:R:L151	6.09	No	No	0	8	7
137	R:R:F117	R:R:W152	12.03	No	Yes	3	8	9
138	R:R:F240	R:R:L118	3.65	Yes	No	0	9	9
139	R:R:P200	R:R:T119	6.99	No	No	0	9	7
140	R:R:I203	R:R:T119	4.56	No	No	0	7	7
141	R:R:I204	R:R:T119	7.6	No	No	0	8	7
142	R:R:L151	R:R:V120	4.47	No	No	0	7	7
143	R:R:D124	R:R:R128	4.76	No	No	9	8	8
144	R:R:R125	R:R:R128	8.53	No	No	0	9	8
145	R:R:F232	R:R:R125	19.24	No	No	0	7	9
146	R:R:V130	R:R:Y126	12.62	Yes	Yes	2	8	7
147	R:R:H131	R:R:Y126	6.53	No	Yes	2	7	7
148	R:R:F206	R:R:Y126	5.16	No	Yes	2	4	7
149	R:R:C207	R:R:Y126	9.41	No	Yes	0	8	7
150	R:R:R210	R:R:Y126	7.2	No	Yes	2	4	7
151	R:R:I211	R:R:Y126	3.63	No	Yes	0	8	7
152	R:R:F127	R:R:H131	6.79	Yes	No	2	5	7
153	R:R:F127	R:R:H134	10.18	Yes	No	2	5	4
154	R:R:F127	R:R:L136	8.53	Yes	No	2	5	4
155	R:R:I211	R:R:V129	6.14	No	Yes	0	8	8
156	R:R:L215	R:R:V129	7.45	Yes	Yes	0	8	8
157	R:R:R218	R:R:V129	3.92	No	Yes	0	5	8
158	R:R:H131	R:R:V130	11.07	No	Yes	2	7	8
159	R:R:R210	R:R:V130	3.92	No	Yes	2	4	8
160	R:R:H134	R:R:L136	7.71	No	No	2	4	4
161	R:R:K138	R:R:N137	4.2	No	No	0	4	4
162	R:R:I139	R:R:T143	4.56	No	No	0	7	3
163	R:R:S140	R:R:T143	4.8	No	No	0	6	3
164	R:R:A145	R:R:R142	4.15	No	No	0	3	4
165	R:R:I146	R:R:R142	6.26	No	No	0	3	4
166	R:R:T155	R:R:W152	6.06	No	Yes	0	7	9
167	R:R:E196	R:R:L158	7.95	No	No	0	5	5
168	R:R:H161	R:R:L162	7.71	No	No	0	7	4
169	R:R:K165	R:R:M167	8.64	No	No	0	4	3
170	R:R:I169	R:R:K165	4.36	No	No	0	1	4
171	R:R:N175	R:R:P168	9.77	No	No	0	4	4
172	R:R:F180	R:R:I169	5.02	Yes	No	0	3	1
173	R:R:N175	R:R:Q170	6.6	No	No	0	4	1
174	R:R:F180	R:R:L176	6.09	Yes	No	0	3	4
175	R:R:F180	R:R:S178	9.25	Yes	No	0	3	4
176	R:R:S179	R:R:S181	3.26	No	No	0	4	4
177	R:R:R251	R:R:S181	5.27	No	No	0	5	4
178	R:R:D273	R:R:I182	5.6	No	No	0	4	3
179	R:R:F276	R:R:I182	12.56	Yes	No	0	4	3
180	R:R:H184	R:R:Q187	6.18	No	No	0	3	2
181	R:R:E190	R:R:H184	20.92	No	No	0	4	3
182	R:R:Q187	R:R:T185	4.25	No	No	0	2	2
183	R:R:L258	R:R:T185	5.9	No	No	0	3	2
184	R:R:A191	R:R:F186	4.16	No	No	0	3	4
185	R:R:F186	R:R:L194	4.87	No	Yes	0	4	4
186	R:R:F186	R:R:F255	12.86	No	No	0	4	5
187	R:R:M192	R:R:W188	9.31	No	No	0	5	5
188	R:R:E190	R:R:H189	8.62	No	No	0	4	5
189	R:R:E190	R:R:F255	5.83	No	No	0	4	5
190	R:R:E196	R:R:M192	4.06	No	No	0	5	5
191	R:R:F193	R:R:L194	3.65	No	Yes	0	6	4
192	R:R:F193	R:R:R251	9.62	No	No	0	6	5
193	R:R:F198	R:R:L194	3.65	No	Yes	0	5	4
194	R:R:I252	R:R:L194	5.71	No	Yes	0	6	4
195	R:R:F197	R:R:F198	9.65	Yes	No	0	8	5
196	R:R:F197	R:R:L201	3.65	Yes	Yes	5	8	7
197	R:R:F197	R:R:F240	5.36	Yes	Yes	5	8	9
198	R:R:F197	R:R:L245	4.87	Yes	No	0	8	6
199	R:R:F197	R:R:V248	15.73	Yes	No	0	8	8
200	R:R:L199	R:R:P200	3.28	No	No	0	4	9
201	R:R:I203	R:R:L199	4.28	No	No	0	7	4
202	R:R:L201	R:R:L205	6.92	Yes	No	0	7	4
203	R:R:F240	R:R:L201	6.09	Yes	Yes	5	9	7
204	R:R:F240	R:R:I204	8.79	Yes	No	0	9	8
205	R:R:F206	R:R:R210	8.55	No	No	2	4	4
206	R:R:I233	R:R:S208	4.64	Yes	No	0	7	8
207	R:R:A237	R:R:S208	3.42	No	No	0	7	8
208	R:R:I211	R:R:I233	7.36	No	Yes	0	8	7
209	R:R:I230	R:R:L215	5.71	Yes	Yes	0	6	8
210	R:R:H223	R:R:Q219	12.36	No	No	0	4	3
211	R:R:I226	R:R:Q219	6.86	No	No	0	6	3
212	R:R:K225	R:R:R222	6.19	No	No	0	5	3
213	R:R:I226	R:R:R222	6.26	No	No	0	6	3
214	R:R:H223	R:R:K227	5.24	No	No	0	4	4
215	R:R:R228	R:R:Y295	6.17	No	No	4	7	7
216	R:R:F296	R:R:R228	9.62	Yes	No	4	8	7
217	R:R:P302	R:R:R228	7.21	No	No	4	8	7
218	R:R:F296	R:R:T231	9.08	Yes	No	0	8	6
219	R:R:F232	R:R:V236	6.55	No	No	0	7	8
220	R:R:F232	R:R:S297	3.96	No	No	0	7	6
221	R:R:V235	R:R:V292	4.81	No	No	4	5	6
222	R:R:L289	R:R:V239	4.47	No	No	0	7	7
223	R:R:V239	R:R:V293	4.81	No	No	0	7	8
224	R:R:F240	R:R:F244	4.29	Yes	No	5	9	8
225	R:R:C243	R:R:F244	8.38	No	No	0	8	8
226	R:R:P246	R:R:T279	3.5	No	No	0	9	7
227	R:R:S247	R:R:T279	4.8	No	No	0	6	7
228	R:R:T279	R:R:V250	7.93	No	No	0	7	5
229	R:R:F276	R:R:R251	6.41	Yes	No	0	4	5
230	R:R:L257	R:R:R253	14.58	No	No	0	3	5
231	R:R:I254	R:R:V272	4.61	No	No	0	4	4
232	R:R:F276	R:R:I254	3.77	Yes	No	0	4	4
233	R:R:T260	R:R:W256	9.7	No	No	0	1	4
234	R:R:L257	R:R:Y269	4.69	No	Yes	0	3	2
235	R:R:L258	R:R:Y269	7.03	No	Yes	0	3	2
236	R:R:E267	R:R:N265	3.94	No	No	0	2	5
237	R:R:E267	R:R:R270	13.96	No	No	0	2	1
238	R:R:V268	R:R:Y269	5.05	No	Yes	0	1	2
239	R:R:F276	R:R:F277	10.72	Yes	No	0	4	5
240	R:R:F276	R:R:L280	3.65	Yes	No	0	4	5
241	R:R:L280	R:R:Y284	8.21	No	Yes	0	5	7
242	R:R:T283	R:R:Y284	6.24	No	Yes	0	8	7
243	R:R:M285	R:R:M288	5.78	Yes	No	0	5	8
244	R:R:L289	R:R:M285	4.24	No	Yes	0	7	5
245	R:R:D290	R:R:N286	4.04	Yes	Yes	1	9	9
246	R:R:D290	R:R:Y294	6.9	Yes	Yes	1	9	9
247	R:R:F301	R:R:Y294	4.13	No	Yes	1	9	9
248	R:R:F296	R:R:Y295	9.28	Yes	No	4	8	7
249	R:R:P302	R:R:Y295	13.91	No	No	4	8	7
250	R:R:S297	R:R:S298	3.26	No	No	0	6	8
251	R:R:P299	R:R:S298	3.56	No	No	0	5	8
252	R:R:S298	R:R:S300	6.52	No	No	0	8	5
253	R:R:F304	R:R:F305	9.65	Yes	No	0	4	6
254	R:R:S281	R:R:V33	3.23	No	No	0	6	5
255	R:R:S261	R:R:V268	3.23	No	No	0	3	1
256	R:R:V235	R:R:V293	3.21	No	No	0	5	8
257	R:R:S247	R:R:T283	3.2	No	No	0	6	8
258	R:R:S261	R:R:T260	3.2	No	No	0	3	1
259	R:R:A174	R:R:D92	3.09	No	No	0	2	4
260	R:R:I233	R:R:V236	3.07	Yes	No	0	7	8
261	R:R:K28	R:R:V29	3.04	No	No	0	3	5
262	R:R:L30	R:R:S281	3	No	No	0	5	6
263	R:R:L245	R:R:V249	2.98	No	No	0	6	6
264	R:R:N303	R:R:S306	2.98	No	No	0	4	4
265	R:R:I212	R:R:I230	2.94	Yes	Yes	7	5	6
266	R:R:I212	R:R:I233	2.94	Yes	Yes	0	5	7
267	R:R:I238	R:R:I242	2.94	No	No	0	5	5
268	R:R:I212	R:R:M234	2.92	Yes	No	7	5	4
269	R:R:I230	R:R:M234	2.92	Yes	No	7	6	4
270	R:R:I242	R:R:M285	2.92	No	Yes	0	5	5
271	R:R:I169	R:R:K15	2.91	No	No	0	1	3
272	R:R:F95	R:R:P99	2.89	Yes	No	0	7	5
273	R:R:I26	R:R:L274	2.85	No	No	0	5	1
274	R:R:I77	R:R:L42	2.85	No	No	0	6	7
275	R:R:I139	R:R:L136	2.85	No	No	0	7	4
276	R:R:I154	R:R:L158	2.85	No	No	0	5	5
277	R:R:I226	R:R:L215	2.85	No	Yes	0	6	8
278	R:R:C183	R:R:F180	2.79	No	Yes	0	1	3
279	R:R:P31	R:R:Y87	2.78	Yes	Yes	0	6	6
280	R:R:L102	R:R:L163	2.77	No	No	0	5	5
281	R:R:P168	R:R:W93	2.7	No	Yes	0	4	9
282	R:R:F180	R:R:V20	2.62	Yes	No	0	3	2
283	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
284	R:R:H161	R:R:K164	2.62	No	No	0	7	4
285	R:R:F296	R:R:V235	2.62	Yes	No	4	8	5
286	R:R:F296	R:R:V292	2.62	Yes	No	4	8	6
287	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
288	R:R:I212	R:R:R216	2.51	Yes	No	7	5	4
289	R:R:I230	R:R:R216	2.51	Yes	No	7	6	4
290	R:R:F282	R:R:I278	2.51	No	No	0	7	6
291	R:R:M167	R:R:R101	2.48	No	No	0	3	6
292	R:R:F67	R:R:L49	2.44	Yes	No	0	6	7
293	R:R:F127	R:R:N137	2.42	Yes	No	0	5	4
294	R:R:H161	R:R:H189	2.39	No	No	0	7	5
295	R:R:H259	R:R:W256	2.12	No	No	0	1	4
296	R:R:G157	R:R:V160	1.84	No	No	0	5	4
297	R:R:A122	R:R:C207	1.81	No	No	0	9	8
298	R:R:G153	R:R:I156	1.76	No	No	0	4	4
299	R:R:G157	R:R:I156	1.76	No	No	0	5	4
300	R:R:G44	R:R:L43	1.71	No	No	0	7	4
301	R:R:G46	R:R:L49	1.71	No	No	0	4	7
302	R:R:A144	R:R:S61	1.71	No	No	0	7	6
303	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
304	R:R:A275	R:R:V250	1.7	No	No	0	5	5
305	R:R:M84	R:R:P31	1.68	No	Yes	0	7	6
306	R:R:C312	R:R:I309	1.64	No	No	0	5	5
307	R:R:N303	R:R:P299	1.63	No	No	0	4	5
308	R:R:A145	R:R:I64	1.62	No	No	0	3	7
309	R:R:S214	R:R:V129	1.62	No	Yes	0	5	8
310	R:R:S214	R:R:V130	1.62	No	Yes	0	5	8
311	R:R:S271	R:R:V272	1.62	No	No	0	3	4
312	R:R:S306	R:R:T307	1.6	No	No	0	4	4
313	R:R:A229	R:R:L215	1.58	No	Yes	0	7	8
314	R:R:I242	R:R:V241	1.54	No	No	0	5	5
315	R:R:G262	R:R:Y269	1.45	No	Yes	0	4	2
316	R:R:P132	R:R:R218	1.44	No	No	0	8	5
317	R:R:I39	R:R:L43	1.43	No	No	0	5	4
318	R:R:I146	R:R:L150	1.43	No	No	0	3	4
319	R:R:D23	R:R:D24	1.33	No	No	0	4	4
320	R:R:R63	R:R:S58	1.32	No	No	0	7	6
321	R:R:F305	R:R:L308	1.22	No	No	0	6	5
322	R:R:L308	R:R:R311	1.21	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P31	3.4575	4	0	6
2	R:R:L34	4.475	4	6	8
3	R:R:N45	6.27	5	1	9
4	R:R:F52	5.55333	6	1	7
5	R:R:F65	6.1	4	0	7
6	R:R:F67	4.382	5	1	6
7	R:R:D73	8.632	5	1	9
8	R:R:L76	7.67	4	0	7
9	R:R:Y87	4.486	5	6	6
10	R:R:W91	6.318	5	0	4
11	R:R:W93	10.04	6	10	9
12	R:R:F95	10.0025	4	0	7
13	R:R:M109	7.17	4	3	5
14	R:R:I115	7.7525	4	5	8
15	R:R:Y126	7.425	6	2	7
16	R:R:F127	6.108	5	2	5
17	R:R:V129	4.7825	4	0	8
18	R:R:V130	7.3075	4	2	8
19	R:R:W152	6.874	5	3	9
20	R:R:F180	5.154	5	0	3
21	R:R:L194	4.47	4	0	4
22	R:R:F197	7.852	5	5	8
23	R:R:L201	4.5925	4	5	7
24	R:R:I212	2.8275	4	7	5
25	R:R:L215	4.3975	4	0	8
26	R:R:I230	3.52	4	7	6
27	R:R:I233	4.5025	4	0	7
28	R:R:F240	5.95333	6	5	9
29	R:R:Y269	4.988	5	0	2
30	R:R:F276	7.422	5	0	4
31	R:R:Y284	6.31667	6	6	7
32	R:R:M285	4.9275	4	0	5
33	R:R:N286	7.285	4	1	9
34	R:R:D290	7.4275	4	1	9
35	R:R:Y294	5.14556	9	1	9
36	R:R:F296	6.644	5	4	8
37	R:R:F304	10.5475	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F180	R:R:L176	14.8785	6.09	Yes	No	0	3	4
2	R:R:L176	R:R:W91	16.3851	3.42	No	Yes	0	4	4
3	R:R:F276	R:R:F277	18.1711	10.72	Yes	No	0	4	5
4	R:R:L258	R:R:Y269	11.6693	7.03	No	Yes	0	3	2
5	R:R:L258	R:R:T185	12.4057	5.9	No	No	0	3	2
6	R:R:Q187	R:R:T185	13.1368	4.25	No	No	0	2	2
7	R:R:H184	R:R:Q187	13.8627	6.18	No	No	0	3	2
8	R:R:E190	R:R:H184	14.5808	20.92	No	No	0	4	3
9	R:R:E190	R:R:F255	18.0327	5.83	No	No	0	4	5
10	R:R:F186	R:R:F255	18.7221	12.86	No	No	0	4	5
11	R:R:F186	R:R:L194	20.0773	4.87	No	Yes	0	4	4
12	R:R:F193	R:R:L194	25.6077	3.65	No	Yes	0	6	4
13	R:R:F193	R:R:R251	38.7889	9.62	No	No	0	6	5
14	R:R:F276	R:R:R251	40.1285	6.41	Yes	No	0	4	5
15	R:R:I26	R:R:L274	15.5809	2.85	No	No	0	5	1
16	R:R:F277	R:R:I26	10.5047	7.54	No	No	0	5	5
17	R:R:I26	R:R:L30	15.4634	8.56	No	No	0	5	5
18	R:R:W91	R:R:Y87	21.5317	6.75	Yes	Yes	0	4	6
19	R:R:E37	R:R:V33	29.1929	4.28	No	No	0	7	5
20	R:R:S281	R:R:V33	30.6917	3.23	No	No	0	6	5
21	R:R:L30	R:R:S281	32.1435	3	No	No	0	5	6
22	R:R:F276	R:R:L280	35.055	3.65	Yes	No	0	4	5
23	R:R:L280	R:R:Y284	35.3892	8.21	No	Yes	0	5	7
24	R:R:L34	R:R:Y284	22.1427	4.69	Yes	Yes	6	8	7
25	R:R:L34	R:R:L80	21.0304	4.15	Yes	No	0	8	8
26	R:R:L76	R:R:Y284	84.1659	8.21	Yes	Yes	0	7	7
27	R:R:L76	R:R:L80	21.5474	4.15	Yes	No	0	7	8
28	R:R:L83	R:R:Y284	21.2393	5.86	No	Yes	6	6	7
29	R:R:E37	R:R:M285	27.6889	6.77	No	Yes	0	7	5
30	R:R:L76	R:R:V287	100	5.96	Yes	No	0	7	8
31	R:R:D73	R:R:V287	99.2375	10.22	Yes	No	0	9	8
32	R:R:D73	R:R:Y294	88.5787	3.45	Yes	Yes	1	9	9
33	R:R:F52	R:R:Y294	77.0086	5.16	Yes	Yes	1	7	9
34	R:R:F52	R:R:R63	74.8257	5.34	Yes	No	0	7	7
35	R:R:L56	R:R:R63	73.7682	4.86	No	No	0	5	7
36	R:R:L56	R:R:S300	74.5568	4.5	No	No	0	5	5
37	R:R:S298	R:R:S300	74.0345	6.52	No	No	0	8	5
38	R:R:S297	R:R:S298	70.8228	3.26	No	No	0	6	8
39	R:R:F232	R:R:S297	70.1491	3.96	No	No	0	7	6
40	R:R:F232	R:R:R125	34.5771	19.24	No	No	0	7	9
41	R:R:R125	R:R:R128	33.7807	8.53	No	No	0	9	8
42	R:R:D124	R:R:R128	31.8928	4.76	No	No	9	8	8
43	R:R:D124	R:R:F65	31.0547	4.78	No	Yes	0	8	7
44	R:R:F65	R:R:V120	20.6256	9.18	Yes	No	0	7	7
45	R:R:F117	R:R:L151	17.6646	6.09	No	No	0	8	7
46	R:R:L151	R:R:V120	19.6438	4.47	No	No	0	7	7
47	R:R:F117	R:R:W152	14.5834	12.03	No	Yes	3	8	9
48	R:R:L107	R:R:Y284	13.3535	4.69	No	Yes	0	6	7
49	R:R:L107	R:R:M103	12.5885	5.65	No	No	0	6	5
50	R:R:M109	R:R:W152	10.5726	4.65	Yes	Yes	3	5	9
51	R:R:F193	R:R:R111	15.0351	8.55	No	No	0	6	8
52	R:R:I115	R:R:R111	10.2175	6.26	Yes	No	0	8	8
53	R:R:F232	R:R:V236	43.1783	6.55	No	No	0	7	8
54	R:R:I233	R:R:V236	42.3271	3.07	Yes	No	0	7	8
55	R:R:I211	R:R:I233	28.3025	7.36	No	Yes	0	8	7
56	R:R:I211	R:R:Y126	16.2989	3.63	No	Yes	0	8	7
57	R:R:H131	R:R:Y126	10.3376	6.53	No	Yes	2	7	7
58	R:R:I211	R:R:V129	12.0244	6.14	No	Yes	0	8	8
59	R:R:I212	R:R:I233	11.8077	2.94	Yes	Yes	0	5	7
60	R:R:I226	R:R:L215	12.1158	2.85	No	Yes	0	6	8
61	R:R:L289	R:R:M285	17.0144	4.24	No	Yes	0	7	5
62	R:R:L289	R:R:V239	15.4686	4.47	No	No	0	7	7
63	R:R:V239	R:R:V293	13.9175	4.81	No	No	0	7	8
64	R:R:V235	R:R:V293	12.3613	3.21	No	No	0	5	8
65	R:R:L30	R:R:Y87	39.5984	4.69	No	Yes	0	5	6
66	R:R:L34	R:R:Y87	40.6533	3.52	Yes	Yes	6	8	6
67	R:R:L83	R:R:Y87	20.8319	4.69	No	Yes	6	6	6
68	R:R:M103	R:R:W93	10.3272	5.82	No	Yes	0	5	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7ZL9

PDB Summary
PDB	7ZL9
Class	A
SubFamily	Alicarboxylic acid
Type	Hydroxycarboxylic acid
SubType	HCA2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.7
Date	2023-04-12
D.O.I.	10.1038/s41467-023-37177-6

Net Summary
I_min	3.26
Number of Linked Nodes	285
Number of Links	322
Number of Hubs	37
Number of Links mediated by Hubs	150
Number of Communities	10
Number of Nodes involved in Communities	54
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	62933
Length Of Smallest Path	3
Average Path Length	17.6605
Length of Longest Path	42
Minimum Path Strength	1.215
Average Path Strength	6.18807
Maximum Path Strength	20.5833
Minimum Path Correlation	0.7
Average Path Correlation	0.930254
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	42.5463
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.0111
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>7ZL9_Chain_R L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L V V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N V M L D P V V Y Y F S S P S F P N F F S T L I N R C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Gi1/&β;1/&γ;2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/&β;1/&γ;2	3.01	2023-10-11	To be published
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/&β;1/&γ;2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/&β;1/&γ;2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/&β;1/&γ;2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Gi1/&β;1/&γ;2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/&β;1/&γ;2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Acifran	-	Gi1/&β;1/&γ;2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	-	-	Gi1/&β;1/&γ;2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/&β;1/&γ;2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/&β;1/&γ;2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Gi1/&β;1/&γ;2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Go/&β;1/&γ;2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Go/&β;1/&γ;2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	GSK256073	-	Go/&β;1/&γ;2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Gi1/&β;1/&γ;2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/&β;1/&γ;2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/&β;1/&γ;2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/&β;1/&γ;2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Beta-hydroxybutyrate	Compound 9n	Gi1/&β;1/&γ;2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Gi1/&β;1/&γ;2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Acipimox	-	Go/&β;1/&γ;2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MMF	-	Go/&β;1/&γ;2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/&β;1/&γ;2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/&β;1/&γ;2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/&β;1/&γ;2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MMF	-	Gi1/&β;1/&γ;2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Gi1/&β;1/&γ;2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8

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