psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F21	R:R:L11	6.09	No	No	10	2	8
2	R:R:L11	R:R:R270	3.64	No	No	10	8	1
3	R:R:D14	R:R:E12	6.5	No	No	0	5	5
4	R:R:C266	R:R:I13	6.55	No	No	0	7	3
5	R:R:D14	R:R:N171	13.46	No	Yes	0	5	1
6	R:R:C18	R:R:K15	4.85	No	Yes	0	9	3
7	R:R:I169	R:R:K15	4.36	No	Yes	7	1	3
8	R:R:K15	R:R:N171	5.6	Yes	Yes	7	3	1
9	R:R:F180	R:R:K15	4.96	Yes	Yes	7	3	3
10	R:R:N17	R:R:T263	8.77	No	No	0	5	3
11	R:R:C18	R:R:C183	7.28	No	No	0	9	1
12	R:R:C19	R:R:C266	7.28	No	No	0	4	7
13	R:R:C19	R:R:Y269	6.72	No	Yes	0	4	2
14	R:R:F21	R:R:R270	11.76	No	No	10	2	1
15	R:R:D273	R:R:F21	8.36	No	No	0	4	2
16	R:R:I26	R:R:R22	7.52	Yes	Yes	0	5	3
17	R:R:R22	R:R:V27	15.69	Yes	No	0	3	3
18	R:R:R22	R:R:Y87	5.14	Yes	Yes	3	3	6
19	R:R:R22	R:R:R90	7.46	Yes	No	0	3	4
20	R:R:R22	R:R:W91	25.99	Yes	Yes	3	3	4
21	R:R:D23	R:R:D24	5.32	No	No	0	4	4
22	R:R:D23	R:R:L274	10.86	No	No	0	4	1
23	R:R:F25	R:R:V29	13.11	No	No	0	6	5
24	R:R:F25	R:R:L274	3.65	No	No	0	6	1
25	R:R:F25	R:R:I278	3.77	No	No	0	6	6
26	R:R:I26	R:R:L30	8.56	Yes	No	0	5	5
27	R:R:F277	R:R:I26	7.54	No	Yes	0	5	5
28	R:R:L30	R:R:Y87	4.69	No	Yes	0	5	6
29	R:R:P31	R:R:P32	5.84	Yes	No	0	6	5
30	R:R:E37	R:R:V33	4.28	No	No	0	7	5
31	R:R:L34	R:R:L80	4.15	No	No	0	8	8
32	R:R:L34	R:R:L83	5.54	No	No	3	8	6
33	R:R:L34	R:R:Y284	4.69	No	Yes	3	8	7
34	R:R:F40	R:R:L36	3.65	No	No	0	6	4
35	R:R:E37	R:R:M285	6.77	No	Yes	0	7	5
36	R:R:F38	R:R:L80	7.31	No	No	0	7	8
37	R:R:F38	R:R:P81	7.22	No	No	0	7	8
38	R:R:F40	R:R:M288	3.73	No	No	0	6	8
39	R:R:G41	R:R:V287	3.68	No	No	0	8	8
40	R:R:G44	R:R:P291	4.06	No	No	0	7	9
41	R:R:N45	R:R:V70	5.91	Yes	No	1	9	8
42	R:R:D73	R:R:N45	12.12	Yes	Yes	1	9	9
43	R:R:I77	R:R:N45	4.25	No	Yes	0	6	9
44	R:R:N45	R:R:Y294	5.81	Yes	Yes	1	9	9
45	R:R:F305	R:R:L47	4.87	No	No	0	6	6
46	R:R:A48	R:R:Y294	4	No	Yes	0	9	9
47	R:R:F54	R:R:W50	12.03	No	No	0	4	4
48	R:R:F304	R:R:W50	4.01	Yes	No	0	4	4
49	R:R:F301	R:R:I51	12.56	No	No	0	9	7
50	R:R:F304	R:R:I51	13.82	Yes	No	0	4	7
51	R:R:F52	R:R:W59	4.01	Yes	No	1	7	6
52	R:R:F52	R:R:R63	5.34	Yes	Yes	0	7	7
53	R:R:F52	R:R:L66	4.87	Yes	No	1	7	8
54	R:R:F52	R:R:F67	4.29	Yes	Yes	1	7	6
55	R:R:F52	R:R:Y294	5.16	Yes	Yes	1	7	9
56	R:R:F301	R:R:F52	9.65	No	Yes	1	9	7
57	R:R:C53	R:R:F54	4.19	No	No	0	4	4
58	R:R:H55	R:R:L56	3.86	No	No	0	5	5
59	R:R:F304	R:R:H55	14.71	Yes	No	0	4	5
60	R:R:L56	R:R:R63	4.86	No	Yes	0	5	7
61	R:R:L56	R:R:S300	4.5	No	No	0	5	5
62	R:R:F67	R:R:W59	6.01	Yes	No	1	6	6
63	R:R:K60	R:R:S62	6.12	No	No	8	7	8
64	R:R:K60	R:R:R63	8.66	No	Yes	0	7	7
65	R:R:K60	R:R:R128	3.71	No	Yes	8	7	8
66	R:R:D124	R:R:S62	8.83	No	No	8	8	8
67	R:R:R128	R:R:S62	7.91	Yes	No	8	8	8
68	R:R:I64	R:R:N141	4.25	No	No	0	7	2
69	R:R:A144	R:R:I64	4.87	No	No	0	7	7
70	R:R:F65	R:R:V120	9.18	Yes	No	0	7	7
71	R:R:D124	R:R:F65	4.78	No	Yes	0	8	7
72	R:R:A144	R:R:F65	4.16	No	Yes	0	7	7
73	R:R:F65	R:R:I147	6.28	Yes	No	0	7	5
74	R:R:L66	R:R:V121	4.47	No	No	0	8	9
75	R:R:L66	R:R:Y294	5.86	No	Yes	1	8	9
76	R:R:F67	R:R:V70	5.24	Yes	No	1	6	8
77	R:R:F67	R:R:V71	3.93	Yes	No	0	6	6
78	R:R:F117	R:R:N68	20.54	No	No	4	8	9
79	R:R:N68	R:R:S148	8.94	No	No	0	9	8
80	R:R:N68	R:R:W152	9.04	No	Yes	4	9	9
81	R:R:D290	R:R:L69	6.79	Yes	No	1	9	9
82	R:R:L69	R:R:Y294	4.69	No	Yes	1	9	9
83	R:R:V70	R:R:Y294	6.31	No	Yes	1	8	9
84	R:R:D73	R:R:N286	5.39	Yes	Yes	1	9	9
85	R:R:D73	R:R:V287	10.22	Yes	No	0	9	8
86	R:R:D290	R:R:D73	11.98	Yes	Yes	1	9	9
87	R:R:F74	R:R:I77	5.02	No	No	0	7	6
88	R:R:L75	R:R:M106	5.65	No	No	0	6	5
89	R:R:L76	R:R:L80	4.15	Yes	No	0	7	8
90	R:R:L76	R:R:N110	12.36	Yes	No	0	7	9
91	R:R:L76	R:R:Y284	8.21	Yes	Yes	0	7	7
92	R:R:L76	R:R:V287	5.96	Yes	No	0	7	8
93	R:R:C79	R:R:M103	4.86	No	No	0	6	5
94	R:R:C79	R:R:M106	4.86	No	No	0	6	5
95	R:R:F82	R:R:F95	10.72	No	Yes	0	6	7
96	R:R:L83	R:R:Y87	4.69	No	Yes	3	6	6
97	R:R:L83	R:R:Y284	5.86	No	Yes	3	6	7
98	R:R:D85	R:R:R89	14.29	No	No	0	4	4
99	R:R:D85	R:R:F95	8.36	No	Yes	0	4	7
100	R:R:N86	R:R:W93	10.17	No	Yes	0	5	9
101	R:R:W91	R:R:Y87	6.75	Yes	Yes	3	4	6
102	R:R:F277	R:R:W91	12.03	No	Yes	0	5	4
103	R:R:F95	R:R:W93	18.04	Yes	Yes	0	7	9
104	R:R:C100	R:R:W93	6.53	No	Yes	11	9	9
105	R:R:M103	R:R:W93	5.82	No	Yes	0	5	9
106	R:R:C177	R:R:W93	16.98	No	Yes	11	9	9
107	R:R:G96	R:R:P99	4.06	No	No	0	7	5
108	R:R:D97	R:R:R101	10.72	No	No	0	3	6
109	R:R:I98	R:R:P99	5.08	No	No	0	2	5
110	R:R:C100	R:R:M167	6.48	No	No	0	9	3
111	R:R:C100	R:R:C177	7.28	No	No	11	9	9
112	R:R:L107	R:R:M103	5.65	No	No	0	6	5
113	R:R:C177	R:R:L104	4.76	No	No	0	9	5
114	R:R:F105	R:R:M109	13.68	No	Yes	4	6	5
115	R:R:F105	R:R:T159	6.49	No	No	4	6	7
116	R:R:F105	R:R:L163	17.05	No	No	0	6	5
117	R:R:L107	R:R:Y284	4.69	No	Yes	0	6	7
118	R:R:M109	R:R:W152	4.65	Yes	Yes	4	5	9
119	R:R:I156	R:R:M109	5.83	No	Yes	0	4	5
120	R:R:M109	R:R:T159	4.52	Yes	No	4	5	7
121	R:R:N110	R:R:N286	12.26	No	Yes	0	9	9
122	R:R:I115	R:R:R111	6.26	No	No	0	8	8
123	R:R:F193	R:R:R111	8.55	No	No	0	6	8
124	R:R:E196	R:R:Q112	8.92	No	No	0	5	7
125	R:R:G113	R:R:T155	3.64	No	No	0	7	7
126	R:R:N286	R:R:S114	7.45	Yes	No	0	9	9
127	R:R:F240	R:R:I115	7.54	Yes	No	6	9	8
128	R:R:F244	R:R:I115	13.82	No	No	6	8	8
129	R:R:I116	R:R:L151	4.28	No	No	0	5	7
130	R:R:F117	R:R:L151	6.09	No	No	0	8	7
131	R:R:F117	R:R:W152	12.03	No	Yes	4	8	9
132	R:R:F240	R:R:L118	3.65	Yes	No	0	9	9
133	R:R:P200	R:R:T119	6.99	No	No	0	9	7
134	R:R:I203	R:R:T119	4.56	No	No	0	7	7
135	R:R:I204	R:R:T119	7.6	No	No	0	8	7
136	R:R:L151	R:R:V120	4.47	No	No	0	7	7
137	R:R:D124	R:R:R128	4.76	No	Yes	8	8	8
138	R:R:R125	R:R:R128	8.53	No	Yes	0	9	8
139	R:R:F232	R:R:R125	19.24	No	No	0	7	9
140	R:R:V130	R:R:Y126	12.62	Yes	Yes	2	8	7
141	R:R:H131	R:R:Y126	6.53	No	Yes	2	7	7
142	R:R:F206	R:R:Y126	5.16	No	Yes	2	4	7
143	R:R:C207	R:R:Y126	9.41	No	Yes	0	8	7
144	R:R:R210	R:R:Y126	7.2	No	Yes	2	4	7
145	R:R:I211	R:R:Y126	3.63	No	Yes	0	8	7
146	R:R:F127	R:R:H131	6.79	Yes	No	2	5	7
147	R:R:F127	R:R:H134	10.18	Yes	No	2	5	4
148	R:R:F127	R:R:L136	8.53	Yes	No	2	5	4
149	R:R:I211	R:R:V129	6.14	No	Yes	0	8	8
150	R:R:L215	R:R:V129	7.45	Yes	Yes	0	8	8
151	R:R:H131	R:R:V130	11.07	No	Yes	2	7	8
152	R:R:R210	R:R:V130	3.92	No	Yes	2	4	8
153	R:R:H134	R:R:L136	7.71	No	No	2	4	4
154	R:R:I139	R:R:T143	4.56	No	No	0	7	3
155	R:R:S140	R:R:T143	4.8	No	No	0	6	3
156	R:R:T155	R:R:W152	6.06	No	Yes	0	7	9
157	R:R:E196	R:R:L158	7.95	No	No	0	5	5
158	R:R:H161	R:R:L162	7.71	No	No	0	7	4
159	R:R:N175	R:R:P168	9.77	No	No	0	4	4
160	R:R:I169	R:R:N171	5.66	No	Yes	7	1	1
161	R:R:F180	R:R:I169	5.02	Yes	No	7	3	1
162	R:R:L176	R:R:N171	6.87	No	Yes	0	4	1
163	R:R:F180	R:R:L176	6.09	Yes	No	0	3	4
164	R:R:F180	R:R:S178	9.25	Yes	No	0	3	4
165	R:R:R251	R:R:S181	5.27	No	No	0	5	4
166	R:R:D273	R:R:I182	5.6	No	No	0	4	3
167	R:R:F276	R:R:I182	12.56	Yes	No	0	4	3
168	R:R:H184	R:R:Q187	6.18	No	No	0	3	2
169	R:R:E190	R:R:H184	20.92	No	No	0	4	3
170	R:R:Q187	R:R:T185	4.25	No	No	0	2	2
171	R:R:L258	R:R:T185	5.9	No	No	0	3	2
172	R:R:A191	R:R:F186	4.16	No	No	0	3	4
173	R:R:F186	R:R:L194	4.87	No	Yes	0	4	4
174	R:R:F186	R:R:F255	12.86	No	No	0	4	5
175	R:R:M192	R:R:W188	9.31	No	No	0	5	5
176	R:R:E190	R:R:H189	8.62	No	No	0	4	5
177	R:R:E190	R:R:F255	5.83	No	No	0	4	5
178	R:R:E196	R:R:M192	4.06	No	No	0	5	5
179	R:R:F193	R:R:L194	3.65	No	Yes	0	6	4
180	R:R:F193	R:R:R251	9.62	No	No	0	6	5
181	R:R:F198	R:R:L194	3.65	No	Yes	0	5	4
182	R:R:I252	R:R:L194	5.71	No	Yes	0	6	4
183	R:R:F197	R:R:F198	9.65	Yes	No	0	8	5
184	R:R:F197	R:R:L201	3.65	Yes	Yes	6	8	7
185	R:R:F197	R:R:F240	5.36	Yes	Yes	6	8	9
186	R:R:F197	R:R:L245	4.87	Yes	No	0	8	6
187	R:R:F197	R:R:V248	15.73	Yes	No	0	8	8
188	R:R:I203	R:R:L199	4.28	No	No	0	7	4
189	R:R:L201	R:R:L205	6.92	Yes	No	0	7	4
190	R:R:F240	R:R:L201	6.09	Yes	Yes	6	9	7
191	R:R:F240	R:R:I204	8.79	Yes	No	0	9	8
192	R:R:F206	R:R:R210	8.55	No	No	2	4	4
193	R:R:I233	R:R:S208	4.64	Yes	No	0	7	8
194	R:R:I211	R:R:I233	7.36	No	Yes	0	8	7
195	R:R:I230	R:R:L215	5.71	Yes	Yes	0	6	8
196	R:R:H223	R:R:Q219	12.36	No	No	0	4	3
197	R:R:I226	R:R:Q219	6.86	No	No	0	6	3
198	R:R:K225	R:R:R222	6.19	No	No	0	5	3
199	R:R:I226	R:R:R222	6.26	No	No	0	6	3
200	R:R:H223	R:R:K227	5.24	No	No	0	4	4
201	R:R:R228	R:R:Y295	6.17	No	No	5	7	7
202	R:R:F296	R:R:R228	9.62	Yes	No	5	8	7
203	R:R:P302	R:R:R228	7.21	No	No	5	8	7
204	R:R:F296	R:R:T231	9.08	Yes	No	0	8	6
205	R:R:F232	R:R:V236	6.55	No	No	0	7	8
206	R:R:F232	R:R:S297	3.96	No	No	0	7	6
207	R:R:V235	R:R:V292	4.81	No	No	5	5	6
208	R:R:L289	R:R:V239	4.47	No	No	0	7	7
209	R:R:V239	R:R:V293	4.81	No	No	0	7	8
210	R:R:F240	R:R:F244	4.29	Yes	No	6	9	8
211	R:R:C243	R:R:F244	8.38	No	No	0	8	8
212	R:R:S247	R:R:T279	4.8	No	No	0	6	7
213	R:R:T279	R:R:V250	7.93	No	No	0	7	5
214	R:R:F276	R:R:R251	6.41	Yes	No	0	4	5
215	R:R:L257	R:R:R253	14.58	No	No	0	3	5
216	R:R:I254	R:R:V272	4.61	No	No	0	4	4
217	R:R:F276	R:R:I254	3.77	Yes	No	0	4	4
218	R:R:T260	R:R:W256	9.7	No	No	0	1	4
219	R:R:L257	R:R:Y269	4.69	No	Yes	0	3	2
220	R:R:L258	R:R:Y269	7.03	No	Yes	0	3	2
221	R:R:E267	R:R:N265	3.94	No	No	0	2	5
222	R:R:E267	R:R:R270	13.96	No	No	0	2	1
223	R:R:V268	R:R:Y269	5.05	No	Yes	0	1	2
224	R:R:F276	R:R:F277	10.72	Yes	No	0	4	5
225	R:R:F276	R:R:L280	3.65	Yes	No	0	4	5
226	R:R:L280	R:R:Y284	8.21	No	Yes	0	5	7
227	R:R:T283	R:R:Y284	6.24	No	Yes	0	8	7
228	R:R:M285	R:R:M288	5.78	Yes	No	0	5	8
229	R:R:L289	R:R:M285	4.24	No	Yes	0	7	5
230	R:R:D290	R:R:N286	4.04	Yes	Yes	1	9	9
231	R:R:D290	R:R:Y294	6.9	Yes	Yes	1	9	9
232	R:R:F301	R:R:Y294	4.13	No	Yes	1	9	9
233	R:R:F296	R:R:Y295	9.28	Yes	No	5	8	7
234	R:R:P302	R:R:Y295	13.91	No	No	5	8	7
235	R:R:P299	R:R:S298	3.56	No	No	0	5	8
236	R:R:S298	R:R:S300	6.52	No	No	0	8	5
237	R:R:F304	R:R:F305	9.65	Yes	No	0	4	6
238	R:R:P31	R:R:V88	3.53	Yes	No	0	6	3
239	R:R:Q112	R:R:R111	3.5	No	No	0	7	8
240	R:R:P246	R:R:T279	3.5	No	No	0	9	7
241	R:R:G35	R:R:M84	3.49	No	No	0	5	7
242	R:R:L176	R:R:W91	3.42	No	Yes	0	4	4
243	R:R:A237	R:R:S208	3.42	No	No	0	7	8
244	R:R:C19	R:R:T263	3.38	No	No	0	4	3
245	R:R:A108	R:R:T159	3.36	No	No	0	4	7
246	R:R:N45	R:R:P291	3.26	Yes	No	0	9	9
247	R:R:S179	R:R:S181	3.26	No	No	0	4	4
248	R:R:S281	R:R:V33	3.23	No	No	0	6	5
249	R:R:S261	R:R:V268	3.23	No	No	0	3	1
250	R:R:V235	R:R:V293	3.21	No	No	0	5	8
251	R:R:S247	R:R:T283	3.2	No	No	0	6	8
252	R:R:S261	R:R:T260	3.2	No	No	0	3	1
253	R:R:A174	R:R:D92	3.09	No	No	0	2	4
254	R:R:I233	R:R:V236	3.07	Yes	No	0	7	8
255	R:R:K28	R:R:V29	3.04	No	No	0	3	5
256	R:R:L30	R:R:S281	3	No	No	0	5	6
257	R:R:L245	R:R:V249	2.98	No	No	0	6	6
258	R:R:N303	R:R:S306	2.98	No	No	0	4	4
259	R:R:I212	R:R:I230	2.94	Yes	Yes	9	5	6
260	R:R:I212	R:R:I233	2.94	Yes	Yes	0	5	7
261	R:R:I238	R:R:I242	2.94	No	No	0	5	5
262	R:R:I212	R:R:M234	2.92	Yes	No	9	5	4
263	R:R:I230	R:R:M234	2.92	Yes	No	9	6	4
264	R:R:I242	R:R:M285	2.92	No	Yes	0	5	5
265	R:R:F95	R:R:P99	2.89	Yes	No	0	7	5
266	R:R:I26	R:R:L274	2.85	Yes	No	0	5	1
267	R:R:I77	R:R:L42	2.85	No	No	0	6	7
268	R:R:I139	R:R:L136	2.85	No	No	0	7	4
269	R:R:I154	R:R:L158	2.85	No	No	0	5	5
270	R:R:I226	R:R:L215	2.85	No	Yes	0	6	8
271	R:R:P31	R:R:Y87	2.78	Yes	Yes	0	6	6
272	R:R:L102	R:R:L163	2.77	No	No	0	5	5
273	R:R:P168	R:R:W93	2.7	No	Yes	0	4	9
274	R:R:F180	R:R:V20	2.62	Yes	No	0	3	2
275	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
276	R:R:R218	R:R:V129	2.62	No	Yes	0	5	8
277	R:R:H161	R:R:K164	2.62	No	No	0	7	4
278	R:R:F296	R:R:V235	2.62	Yes	No	5	8	5
279	R:R:F296	R:R:V292	2.62	Yes	No	5	8	6
280	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
281	R:R:I146	R:R:R142	2.51	No	No	0	3	4
282	R:R:I212	R:R:R216	2.51	Yes	No	9	5	4
283	R:R:I230	R:R:R216	2.51	Yes	No	9	6	4
284	R:R:F282	R:R:I278	2.51	No	No	0	7	6
285	R:R:K94	R:R:R89	2.48	No	No	0	3	4
286	R:R:M167	R:R:R101	2.48	No	No	0	3	6
287	R:R:F67	R:R:L49	2.44	Yes	No	0	6	7
288	R:R:F127	R:R:N137	2.42	Yes	No	0	5	4
289	R:R:H161	R:R:H189	2.39	No	No	0	7	5
290	R:R:H259	R:R:W256	2.12	No	No	0	1	4
291	R:R:G157	R:R:V160	1.84	No	No	0	5	4
292	R:R:A122	R:R:C207	1.81	No	No	0	9	8
293	R:R:G153	R:R:I156	1.76	No	No	0	4	4
294	R:R:G157	R:R:I156	1.76	No	No	0	5	4
295	R:R:G44	R:R:L43	1.71	No	No	0	7	4
296	R:R:G46	R:R:L49	1.71	No	No	0	4	7
297	R:R:A144	R:R:S61	1.71	No	No	0	7	6
298	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
299	R:R:A275	R:R:V250	1.7	No	No	0	5	5
300	R:R:M84	R:R:P31	1.68	No	Yes	0	7	6
301	R:R:C312	R:R:I309	1.64	No	No	0	5	5
302	R:R:N303	R:R:P299	1.63	No	No	0	4	5
303	R:R:A145	R:R:I64	1.62	No	No	0	3	7
304	R:R:S214	R:R:V129	1.62	No	Yes	0	5	8
305	R:R:S214	R:R:V130	1.62	No	Yes	0	5	8
306	R:R:S271	R:R:V272	1.62	No	No	0	3	4
307	R:R:S306	R:R:T307	1.6	No	No	0	4	4
308	R:R:A229	R:R:L215	1.58	No	Yes	0	7	8
309	R:R:I242	R:R:V241	1.54	No	No	0	5	5
310	R:R:G262	R:R:Y269	1.45	No	Yes	0	4	2
311	R:R:K164	R:R:K165	1.44	No	No	0	4	4
312	R:R:K165	R:R:M167	1.44	No	No	0	4	3
313	R:R:I39	R:R:L43	1.43	No	No	0	5	4
314	R:R:I146	R:R:L150	1.43	No	No	0	3	4
315	R:R:D92	R:R:K94	1.38	No	No	0	4	3
316	R:R:R63	R:R:S58	1.32	Yes	No	0	7	6
317	R:R:R142	R:R:S140	1.32	No	No	0	4	6
318	R:R:N175	R:R:Q170	1.32	No	No	0	4	1
319	R:R:F305	R:R:L308	1.22	No	No	0	6	5
320	R:R:L308	R:R:R311	1.21	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:K15	4.9425	4	7	3
2	R:R:R22	12.36	5	3	3
3	R:R:I26	6.6175	4	0	5
4	R:R:P31	3.4575	4	0	6
5	R:R:N45	6.27	5	1	9
6	R:R:F52	5.55333	6	1	7
7	R:R:R63	5.045	4	0	7
8	R:R:F65	6.1	4	0	7
9	R:R:F67	4.382	5	1	6
10	R:R:D73	9.9275	4	1	9
11	R:R:L76	7.67	4	0	7
12	R:R:Y87	4.81	5	3	6
13	R:R:W91	12.0475	4	3	4
14	R:R:W93	10.04	6	11	9
15	R:R:F95	10.0025	4	0	7
16	R:R:M109	7.17	4	4	5
17	R:R:Y126	7.425	6	2	7
18	R:R:F127	6.108	5	2	5
19	R:R:R128	6.2275	4	8	8
20	R:R:V129	4.4575	4	0	8
21	R:R:V130	7.3075	4	2	8
22	R:R:W152	6.874	5	4	9
23	R:R:N171	7.8975	4	7	1
24	R:R:F180	5.588	5	7	3
25	R:R:L194	4.47	4	0	4
26	R:R:F197	7.852	5	6	8
27	R:R:L201	4.5925	4	6	7
28	R:R:I212	2.8275	4	9	5
29	R:R:L215	4.3975	4	0	8
30	R:R:I230	3.52	4	9	6
31	R:R:I233	4.5025	4	0	7
32	R:R:F240	5.95333	6	6	9
33	R:R:Y269	4.988	5	0	2
34	R:R:F276	7.422	5	0	4
35	R:R:Y284	6.31667	6	3	7
36	R:R:M285	4.9275	4	0	5
37	R:R:N286	7.285	4	1	9
38	R:R:D290	7.4275	4	1	9
39	R:R:Y294	5.3575	8	1	9
40	R:R:F296	6.644	5	5	8
41	R:R:F304	10.5475	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L176	R:R:W91	10.9898	3.42	No	Yes	0	4	4
2	R:R:F276	R:R:F277	11.1914	10.72	Yes	No	0	4	5
3	R:R:L258	R:R:Y269	10.4748	7.03	No	Yes	0	3	2
4	R:R:L258	R:R:T185	11.2041	5.9	No	No	0	3	2
5	R:R:Q187	R:R:T185	11.9309	4.25	No	No	0	2	2
6	R:R:H184	R:R:Q187	12.655	6.18	No	No	0	3	2
7	R:R:E190	R:R:H184	13.3754	20.92	No	No	0	4	3
8	R:R:E190	R:R:F255	14.6146	5.83	No	No	0	4	5
9	R:R:F186	R:R:F255	15.2589	12.86	No	No	0	4	5
10	R:R:F186	R:R:L194	16.5842	4.87	No	Yes	0	4	4
11	R:R:F193	R:R:L194	22.7824	3.65	No	Yes	0	6	4
12	R:R:F193	R:R:R251	36.7387	9.62	No	No	0	6	5
13	R:R:F276	R:R:R251	38.4154	6.41	Yes	No	0	4	5
14	R:R:W91	R:R:Y87	10.4165	6.75	Yes	Yes	3	4	6
15	R:R:I26	R:R:L274	15.7053	2.85	Yes	No	0	5	1
16	R:R:E37	R:R:V33	13.9474	4.28	No	No	0	7	5
17	R:R:S281	R:R:V33	14.664	3.23	No	No	0	6	5
18	R:R:L30	R:R:S281	15.3578	3	No	No	0	5	6
19	R:R:F276	R:R:L280	45.632	3.65	Yes	No	0	4	5
20	R:R:L280	R:R:Y284	46.1266	8.21	No	Yes	0	5	7
21	R:R:L76	R:R:Y284	100	8.21	Yes	Yes	0	7	7
22	R:R:L83	R:R:Y284	38.7452	5.86	No	Yes	3	6	7
23	R:R:E37	R:R:M285	13.2283	6.77	No	Yes	0	7	5
24	R:R:L76	R:R:V287	68.7454	5.96	Yes	No	0	7	8
25	R:R:D73	R:R:V287	68.9965	10.22	Yes	No	0	9	8
26	R:R:D73	R:R:N45	36.064	12.12	Yes	Yes	1	9	9
27	R:R:L76	R:R:N110	33.3346	12.36	Yes	No	0	7	9
28	R:R:N110	R:R:N286	33.2978	12.26	No	Yes	0	9	9
29	R:R:D290	R:R:N286	33.1685	4.04	Yes	Yes	1	9	9
30	R:R:D290	R:R:Y294	65.4948	6.9	Yes	Yes	1	9	9
31	R:R:D290	R:R:D73	33.1165	11.98	Yes	Yes	1	9	9
32	R:R:N45	R:R:Y294	34.0093	5.81	Yes	Yes	1	9	9
33	R:R:F52	R:R:Y294	89.0584	5.16	Yes	Yes	1	7	9
34	R:R:F52	R:R:R63	89.2106	5.34	Yes	Yes	0	7	7
35	R:R:K60	R:R:R63	84.192	8.66	No	Yes	0	7	7
36	R:R:K60	R:R:S62	22.6873	6.12	No	No	8	7	8
37	R:R:K60	R:R:R128	60.8477	3.71	No	Yes	8	7	8
38	R:R:D124	R:R:S62	21.9364	8.83	No	No	8	8	8
39	R:R:D124	R:R:R128	23.6689	4.76	No	Yes	8	8	8
40	R:R:D124	R:R:F65	44.1646	4.78	No	Yes	0	8	7
41	R:R:F65	R:R:V120	32.8983	9.18	Yes	No	0	7	7
42	R:R:F117	R:R:L151	28.0281	6.09	No	No	0	8	7
43	R:R:L151	R:R:V120	31.2774	4.47	No	No	0	7	7
44	R:R:F117	R:R:W152	23.0995	12.03	No	Yes	4	8	9
45	R:R:L107	R:R:Y284	21.7005	4.69	No	Yes	0	6	7
46	R:R:L107	R:R:M103	21.0169	5.65	No	No	0	6	5
47	R:R:M103	R:R:W93	18.3573	5.82	No	Yes	0	5	9
48	R:R:M109	R:R:W152	16.5753	4.65	Yes	Yes	4	5	9
49	R:R:F193	R:R:R111	14.2277	8.55	No	No	0	6	8
50	R:R:R125	R:R:R128	40.0946	8.53	No	Yes	0	9	8
51	R:R:F232	R:R:R125	39.3298	19.24	No	No	0	7	9
52	R:R:F232	R:R:V236	37.8789	6.55	No	No	0	7	8
53	R:R:I233	R:R:V236	37.109	3.07	Yes	No	0	7	8
54	R:R:I211	R:R:I233	24.9765	7.36	No	Yes	0	8	7
55	R:R:I211	R:R:Y126	15.3248	3.63	No	Yes	0	8	7
56	R:R:H131	R:R:Y126	10.3024	6.53	No	Yes	2	7	7
57	R:R:I212	R:R:I233	10.0043	2.94	Yes	Yes	0	5	7
58	R:R:I226	R:R:L215	10.1362	2.85	No	Yes	0	6	8
59	R:R:L30	R:R:Y87	19.2007	4.69	No	Yes	0	5	6
60	R:R:L83	R:R:Y87	38.5346	4.69	No	Yes	3	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7ZL9

PDB Summary
PDB	7ZL9
Class	A
SubFamily	Alicarboxylic acid
Type	Hydroxycarboxylic Acid
SubType	HCA2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.7
Date	2023-04-12
D.O.I.	10.1038/s41467-023-37177-6

Net Summary
I_min	3.56
Number of Linked Nodes	282
Number of Links	320
Number of Hubs	41
Number of Links mediated by Hubs	162
Number of Communities	11
Number of Nodes involved in Communities	61
Number of Links involved in Communities	79

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	105472
Length Of Smallest Path	3
Average Path Length	19.4143
Length of Longest Path	43
Minimum Path Strength	1.215
Average Path Strength	6.87062
Maximum Path Strength	20.84
Minimum Path Correlation	0.7
Average Path Correlation	0.927994
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	38.3651
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9284
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • protein localization • positive regulation of cell communication • regulation of localization • establishment of protein localization • system process • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • cellular macromolecule localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • cellular localization • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • regulation of cellular localization • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • cellular anatomical structure • periplasmic space • cell junction • cell periphery • plasma membrane • membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Cytochromes
SCOP2	Family Identifier	• Cytochromes
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>7ZL9_Chain_R L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L V V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N V M L D P V V Y Y F S S P S F P N F F S T L I N R C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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