Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:K16 7.134204
2R:R:L30 4.3405
3R:R:F52 4.8625407
4R:R:F67 5.0625406
5R:R:L69 4.12449
6R:R:D73 5.014549
7R:R:F74 6.5025407
8R:R:L83 5.6225416
9R:R:Y87 8.0125416
10R:R:W91 6.886514
11R:R:W93 6.305619
12R:R:F105 6.865446
13R:R:L107 5.04416
14R:R:M109 5.25645
15R:R:I115 5.0425418
16R:R:F117 9.6175448
17R:R:R125 6.445449
18R:R:F127 3.625405
19R:R:V130 5.12254248
20R:R:W152 7.8925449
21R:R:I156 2.86444
22R:R:L162 7.24414
23R:R:L176 3.91404
24R:R:S179 4.685414
25R:R:F180 7.05613
26R:R:I182 3.2825413
27R:R:H189 7.998515
28R:R:E190 7.6675414
29R:R:M192 5.2025415
30R:R:E196 6.6525415
31R:R:F197 6.64667618
32R:R:L201 4.082517
33R:R:R210 4.57254244
34R:R:M220 4.7775403
35R:R:F232 5.7475407
36R:R:F240 5.60333619
37R:R:F244 6.88418
38R:R:L245 2.1375406
39R:R:R251 7.6125415
40R:R:Y269 3.985812
41R:R:Y284 5.43625817
42R:R:M285 4.1975405
43R:R:M288 4.375408
44R:R:D290 6.185449
45R:R:Y294 6.12649
46R:R:Y295 4.66286707
47A:A:V34 4.79254115
48A:A:L38 8.38754148
49A:A:K46 7409
50A:A:I49 5.31407
51A:A:M53 4.3954148
52A:A:F191 8.7125405
53A:A:H195 7.51754124
54A:A:K197 5.22254126
55A:A:M198 3.7485147
56A:A:F199 9.31254125
57A:A:R208 5.694159
58A:A:K210 7.051676169
59A:A:W211 6.166509
60A:A:I222 3.7185147
61A:A:F223 4.50754159
62A:A:L249 3.9154159
63A:A:I264 2.5675406
64A:A:F267 4.21409
65A:A:L268 5.0254278
66A:A:Y320 5.045407
67A:A:N331 5.372508
68A:A:F336 5.5075408
69A:A:F354 11.238585
70B:B:L14 5.0475408
71B:B:T34 5.21405
72B:B:V40 4.5925403
73B:B:H54 7.18833629
74B:B:K57 8.1654179
75B:B:W63 6.35667627
76B:B:D76 6.966529
77B:B:K78 5.3575408
78B:B:L79 5.21457
79B:B:I80 8.59428
80B:B:W82 10.07629
81B:B:Y85 11.52424
82B:B:N88 5.0554257
83B:B:K89 7.28529
84B:B:H91 5.275405
85B:B:I93 5.7325457
86B:B:L95 4.83558
87B:B:W99 8.655609
88B:B:M101 4.1785269
89B:B:Y105 4.27286756
90B:B:N110 4.78254294
91B:B:C114 4.29558
92B:B:Y124 6.684556
93B:B:L126 4.5575455
94B:B:V133 5.3825454
95B:B:H142 8.50667679
96B:B:F151 7.1375409
97B:B:N155 6.74754193
98B:B:I157 5.9825407
99B:B:T159 7.655479
100B:B:D163 8.205479
101B:B:W169 7.72167678
102B:B:T173 7.23754195
103B:B:Q176 3.0775474
104B:B:H183 8.014569
105B:B:V187 3.5075469
106B:B:F199 4.955669
107B:B:V200 7.185406
108B:B:S201 4.2975469
109B:B:C204 4.444167
110B:B:K209 9.90333666
111B:B:W211 8.914568
112B:B:F222 8.172538
113B:B:H225 8.95167639
114B:B:S227 3.74436
115B:B:F234 4.7075405
116B:B:F235 6.917147106
117B:B:P236 5.6554107
118B:B:N237 7.78254105
119B:B:F241 9.12436
120B:B:T243 6.83438
121B:B:D247 9.546539
122B:B:R251 9.40833638
123B:B:F253 8.905436
124B:B:D254 3.84409
125B:B:R256 7.28409
126B:B:M262 4.8425404
127B:B:Y264 6.1325405
128B:B:I269 3.4254134
129B:B:F278 56107
130B:B:Y289 6.26137
131B:B:D290 5.2325406
132B:B:D291 4.714138
133B:B:W297 9.52254138
134B:B:H311 9.184599
135B:B:T329 6.68498
136B:B:W332 13.0645179
137B:B:K337 8.865496
138B:B:W339 7.04429799
139G:G:L19 2.7675409
140G:G:Y40 7.94254106
141G:G:D48 5.8345289
142G:G:L51 4.312506
143G:G:V54 3.945406
144G:G:N59 6.0475429
145G:G:F61 6.23167628
146L:L:?1 7.864541110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I182 R:R:Y269 13.1953.63YesYes132
2R:R:I182 R:R:R251 16.863.76YesYes135
3R:R:E190 R:R:R251 11.72512.79YesYes145
4R:R:E37 R:R:Y284 19.97193.37NoYes077
5R:R:E37 R:R:M285 21.18225.41NoYes075
6R:R:F180 R:R:F193 14.148913.93YesNo036
7R:R:E196 R:R:F193 14.63258.16YesNo056
8R:R:E196 R:R:I115 26.57185.47YesYes158
9R:R:D290 R:R:N286 23.87879.42YesNo099
10R:R:H189 R:R:M192 10.00083.94YesYes155
11R:R:E196 R:R:M192 10.72484.06YesYes155
12R:R:F240 R:R:I115 27.48643.77YesYes198
13R:R:F240 R:R:L118 32.07433.65YesNo099
14R:R:L118 R:R:Y294 32.31547.03NoYes099
15R:R:Y294 R:R:Y295 11.68762.98YesYes097
16B:B:M262 B:B:Y264 10.02534.79YesYes045
17B:B:W297 B:B:Y264 11.5928.68YesYes085
18B:B:W297 B:B:Y289 11.6629.65YesYes1387
19B:B:D291 B:B:Y289 11.89273.45YesYes1387
20B:B:C271 B:B:D291 12.38493.11NoYes058
21B:B:C271 B:B:D290 12.47894.67NoYes056
22B:B:D290 B:B:R314 12.62128.34YesNo068
23A:A:W258 B:B:R314 12.53239NoNo058
24A:A:N256 A:A:W258 12.62213.39NoNo085
25A:A:F259 A:A:N256 12.66976.04NoNo098
26A:A:R208 A:A:W211 95.599510YesYes099
27A:A:L39 A:A:R208 47.8044.86NoYes1599
28A:A:F223 A:A:L39 47.80134.87YesNo1599
29A:A:F223 A:A:G40 1004.52YesNo099
30A:A:G40 A:A:K46 99.97625.23NoYes099
31A:A:K46 A:A:L38 33.49512.69YesYes098
32A:A:I222 A:A:L38 33.14915.71YesYes1478
33A:A:F267 A:A:I222 66.08353.77YesYes097
34A:A:F267 A:A:F334 97.62033.22YesNo093
35A:A:F334 A:A:Y320 97.4533.09NoYes037
36A:A:E318 A:A:Y320 96.87426.73NoYes047
37A:A:E318 A:A:K345 96.51624.05NoNo845
38A:A:K345 R:R:K225 96.4112.87NoNo855
39R:R:I226 R:R:K225 47.96594.36NoNo865
40A:A:L348 R:R:I226 47.84734.28NoNo896
41A:A:L348 R:R:V129 95.46292.98NoNo098
42R:R:L215 R:R:V129 94.98354.47NoNo088
43R:R:L215 R:R:M220 94.02454.24NoYes083
44A:A:I344 R:R:M220 93.30524.37NoYes063
45A:A:I344 A:A:T340 92.82553.04NoNo066
46A:A:F336 A:A:T340 92.58576.49YesNo086
47A:A:F336 R:R:H133 90.42663.39YesNo086
48A:A:I343 R:R:H133 88.49675.3NoNo076
49A:A:I343 A:A:N347 87.30354.25NoNo078
50A:A:N347 R:R:R128 81.970614.46NoNo2388
51R:R:D124 R:R:R128 81.77719.53NoNo088
52R:R:D124 R:R:S62 81.53674.42NoNo088
53A:A:C351 R:R:S62 81.29623.44NoNo048
54A:A:C351 A:A:L353 80.81534.76NoNo047
55A:A:L353 R:R:R125 80.33438.5NoYes079
56R:R:R125 R:R:Y294 78.88678.23YesYes499
57A:A:L249 A:A:R208 47.82323.64YesYes1599
58A:A:F223 A:A:L249 47.81794.87YesYes1599
59A:A:C224 A:A:K46 66.38614.85NoYes079
60A:A:C224 A:A:I222 33.13823.27NoYes077
61A:A:C224 A:A:I49 33.21873.27NoYes077
62A:A:F267 A:A:I49 33.03895.02YesYes097
63A:A:F354 R:R:K225 48.329237.22YesNo855
64A:A:F354 A:A:L348 47.85524.87YesNo859
65R:R:F117 R:R:L69 11.21213.65YesYes489
66R:R:C243 R:R:M285 23.12673.24NoYes085
67A:A:F215 B:B:W99 87.005110.02NoYes099
68A:A:F215 A:A:W211 87.01925.01NoYes099
69A:A:K210 B:B:D186 43.18344.15YesNo1699
70B:B:D186 B:B:Y145 86.31373.45NoNo098
71B:B:M101 B:B:Y145 86.34864.79YesNo098
72B:B:L117 B:B:M101 86.50474.24NoYes099
73B:B:L117 B:B:W99 86.52144.56NoYes099
74B:B:C204 B:B:D186 43.1136.22YesNo1679
75A:A:K210 B:B:D228 43.03268.3YesNo1699
76B:B:C204 B:B:D228 43.03263.11YesNo1679
77B:B:K209 B:B:W211 10.75668.12YesYes668
78B:B:F199 B:B:W211 14.78895.01YesYes698
79B:B:F199 B:B:V213 74.02912.62YesNo094
80B:B:R197 B:B:V213 74.36265.23NoNo054
81B:B:D195 B:B:R197 75.02964.76NoNo055
82B:B:A193 B:B:D195 75.36313.09NoNo045
83B:B:A193 B:B:F234 75.69656.93NoYes045
84B:B:F234 B:B:V200 76.07435.24YesYes056
85B:B:F241 B:B:V200 78.375414.42YesYes066
86B:B:F241 B:B:F253 79.00267.5YesYes366
87B:B:F253 B:B:T243 33.75157.78YesYes368
88B:B:H225 B:B:T243 33.87649.58YesYes398
89B:B:H225 B:B:S245 34.27111.16YesNo399
90B:B:S227 B:B:S245 34.33193.26YesNo369
91B:B:D246 B:B:S227 85.98232.94NoYes096
92B:B:D228 B:B:D246 86.008413.31NoNo099
93B:B:F253 B:B:R251 50.62738.55YesYes368
94B:B:H225 B:B:R251 34.146114.67YesYes398
95B:B:D247 B:B:H225 34.27767.56YesYes399
96B:B:D247 B:B:S227 51.53155.89YesYes396
97B:B:R251 B:B:T249 17.07817.76YesNo086
98B:B:D247 B:B:T249 17.20635.78YesNo096
99B:B:F151 B:B:I157 21.128812.56YesYes097
100B:B:I157 B:B:I171 42.25532.94YesNo076
101B:B:I171 B:B:N155 43.26117.08NoYes063
102B:B:D153 B:B:N155 52.31264.04NoYes053
103B:B:D153 B:B:Q156 53.31836.53NoNo055
104B:B:L152 B:B:Q156 36.21543.99NoNo035
105B:B:L152 B:B:V158 18.44292.98NoNo035
106B:B:F199 B:B:V158 37.89093.93YesNo095
107B:B:L168 B:B:Q156 18.10865.32NoNo065
108B:B:L168 B:B:V158 19.11352.98NoNo065
109B:B:L152 B:B:L192 18.44295.54NoNo035
110B:B:F199 B:B:L192 18.77784.87YesNo095
111B:B:I123 B:B:Y111 13.08134.84NoNo064
112B:B:F151 B:B:I123 14.08616.28YesNo096
113B:B:I157 B:B:W169 16.09813.52YesYes078
114L:L:?1 R:R:Y284 16.07428.59YesYes107
115R:R:C243 R:R:N286 23.36923.15NoNo089
116R:R:D290 R:R:Y294 32.79364.6YesYes499
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:R22 R:R:W91 4 0 No Yes 3 4 2 1
R:R:I26 R:R:W91 7.05 0 No Yes 5 4 2 1
R:R:L30 R:R:Y87 8.21 0 Yes Yes 5 6 2 1
R:R:E37 R:R:Y284 3.37 0 No Yes 7 7 2 1
R:R:L76 R:R:Y284 7.03 0 No Yes 7 7 2 1
R:R:C79 R:R:L107 3.17 0 No Yes 6 6 2 1
R:R:L80 R:R:L83 5.54 1 No Yes 8 6 2 1
R:R:L80 R:R:Y284 8.21 1 No Yes 8 7 2 1
R:R:L107 R:R:L83 5.54 1 Yes Yes 6 6 1 1
R:R:L83 R:R:Y284 3.52 1 Yes Yes 6 7 1 1
L:L:?1 R:R:L83 7.89 1 Yes Yes 0 6 0 1
R:R:N86 R:R:Y87 4.65 1 No Yes 5 6 1 1
R:R:N86 R:R:W93 7.91 1 No Yes 5 9 1 2
L:L:?1 R:R:N86 5.59 1 Yes No 0 5 0 1
R:R:W91 R:R:Y87 9.65 1 Yes Yes 4 6 1 1
L:L:?1 R:R:Y87 9.54 1 Yes Yes 0 6 0 1
R:R:F277 R:R:W91 10.02 0 No Yes 5 4 2 1
L:L:?1 R:R:W91 3.71 1 Yes Yes 0 4 0 1
R:R:C177 R:R:W93 7.84 1 No Yes 9 9 2 2
R:R:C177 R:R:L104 4.76 1 No No 9 5 2 1
R:R:L104 R:R:S179 3 1 No Yes 5 4 1 1
L:L:?1 R:R:L104 7.89 1 Yes No 0 5 0 1
R:R:L107 R:R:Y284 4.69 1 Yes Yes 6 7 1 1
L:L:?1 R:R:L107 6.76 1 Yes Yes 0 6 0 1
R:R:F180 R:R:R111 4.28 1 Yes No 3 8 2 1
R:R:R111 R:R:Y284 3.09 1 No Yes 8 7 1 1
L:L:?1 R:R:R111 12.86 1 Yes No 0 8 0 1
R:R:L162 R:R:S179 3 1 Yes Yes 4 4 2 1
R:R:H189 R:R:L162 15.43 1 Yes Yes 5 4 2 2
L:L:?1 R:R:S178 6.11 1 Yes No 0 4 0 1
R:R:H189 R:R:S179 4.18 1 Yes Yes 5 4 2 1
L:L:?1 R:R:S179 8.56 1 Yes Yes 0 4 0 1
R:R:F180 R:R:H189 9.05 1 Yes Yes 3 5 2 2
R:R:F180 R:R:L280 6.09 1 Yes No 3 5 2 1
L:L:?1 R:R:L280 9.01 1 Yes No 0 5 0 1
R:R:T283 R:R:Y284 4.99 0 No Yes 8 7 2 1
L:L:?1 R:R:Y284 8.59 1 Yes Yes 0 7 0 1
R:R:L176 R:R:S178 1.5 0 Yes No 4 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8K5DGSK2560738K5D-HCA2-GSK256073
84.62Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
75.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
75.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
71.43Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
71.43Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
69.23Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
69.23Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
69.23Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
69.23Consensusgi_hcarOrthosteric Ligandgi_hca
69.23Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
66.67Single8IHKAcifran8IHK-HCA3-Acifran
64.29Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
64.29Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
61.54Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
61.54Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
61.54Single8K5CAcipimox8K5C-HCA2-Acipimox
61.54Consensushca_onOrthosteric Ligandhca2_on hca3_on
61.54Consensushcar_onOrthosteric Ligandhca_on
58.33Single3OE9IT1t3OE9-CXCR4-IT1t
58.33Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
58.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
58.33Single8K5BNiacin8K5B-HCA2-Niacin
57.14Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
57.14Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
57.14Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
53.85Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
53.85Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
53.33Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
52.94Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
52.94Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
50.00Single3OE6IT1t3OE6-CXCR4-IT1t
50.00Single3OE8IT1t3OE8-CXCR4-IT1t
50.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
50.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
50.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
50.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
50.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
47.37Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
47.37Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
47.37Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
47.06Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
47.06Single7K15MKD0467K15-BLT1-MKD046-Na
47.06Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
47.06Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
47.06Consensusblt_offOrthosteric Ligandblt1_off
46.67Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
46.67Single4YAYZD-71554YAY-AT1-ZD-7155
46.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
46.67Single6TOTLemborexant6TOT-OX1-Lemborexant
46.67Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
46.67Single7UL4Alvimopan7UL4-μ-Alvimopan
46.15Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
46.15Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
46.15Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
45.83Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
45.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
45.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
45.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
44.44Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
44.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
43.75Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
42.86Single3ODUIT1t3ODU-CXCR4-IT1t
42.86Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
42.11Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
42.11Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
42.11Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
41.67Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
41.18Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
41.18Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
41.18Consensuscck_onOrthosteric Ligandccka_on cckb_on
40.91Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
40.91Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
40.91Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
40.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
40.00Single4XT1Fractalkine4XT1-US28-Fractalkine
40.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
40.00Single6TPGEMPA6TPG-OX2-EMPA
40.00Single6V9SGTPL114036V9S-OX1-GTPL11403
40.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
40.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
40.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
40.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
40.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
40.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
40.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
40.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
40.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
40.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
40.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
40.00Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
40.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
40.00Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
40.00Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
40.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
40.00Consensuss1p_offOrthosteric Ligands1p1_off
40.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
39.13Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
38.89Single6ZG4HTL00099366ZG4-M1-HTL0009936
38.89Single7DFPSpiperone7DFP-D2-Spiperone
38.89Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
38.89Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
38.89Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
38.89Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
38.89Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
38.89Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
38.89Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
38.89Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
38.89Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
38.89Consensusgs_steroidOrthosteric Ligandgs_bileacid
38.89Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
38.46Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
38.46Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
38.10Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
38.10Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
38.10Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
38.10Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
38.10Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
38.10Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
37.50Single2Y04Salbutamol2Y04-β1-Salbutamol
37.50Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
37.50Single4XT3Fractalkine4XT3-US28-Fractalkine
37.50Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
37.50Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
37.50Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
37.50Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
37.50Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
37.50Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
37.50Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensushcar_offOrthosteric Ligandsuccinate_off
37.50Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
37.50Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
36.84Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
36.84Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
36.84Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
36.84Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
36.84Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
36.84Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
36.84Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
36.84Consensusendothelin_offOrthosteric Ligandetb_off
36.84Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
36.84Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
36.84Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Consensussteroid_onOrthosteric Ligandbileacid_on
36.36Consensusangiotensin_onOrthosteric Ligandat1_on
36.36Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
36.36Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
36.36Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
35.71Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single2Y03Isoprenaline2Y03-β1-Isoprenaline
35.29Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
35.29Single5WIUNemonapride5WIU-D4-Nemonapride
35.29Single5WIVNemonapride5WIV-D4-Nemonapride-Na
35.29Single5WQCEMPA5WQC-OX2-EMPA
35.29Single6D26Fevipiprant6D26-DP2-Fevipiprant
35.29Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
35.29Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
35.29Single6TP6Filorexant6TP6-OX1-Filorexant
35.29Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
35.29Single7C4SS1P7C4S-S1P3-S1P
35.29Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
35.29Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
35.29Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
35.29Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
35.29Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
35.29Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
35.29Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
35.29Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
35.29Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
35.29Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
35.29Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
35.29Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
35.29Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
35.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single7SK9CCX6627SK9-ACKR3-CCX662
35.00Single7XN9L-054,5227XN9-SST2-L-054,522
35.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
35.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
35.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
35.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
35.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
35.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
35.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
35.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
34.78Single6JODAngiotensin II6JOD-AT2-Angiotensin II
34.78Single7C61Ergotamine7C61-5-HT1B-Ergotamine
34.78Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
34.78Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
34.78Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
34.78Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
34.78Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
34.78Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
34.62Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
33.33Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
33.33Single4DJHJDTic4DJH-κ-JDTic
33.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
33.33Single4S0VSuvorexant4S0V-OX2-Suvorexant
33.33Single5DHHSB-6121115DHH-NOP-SB-612111
33.33Single5WS3EMPA5WS3-OX2-EMPA
33.33Single5ZKQABT-4915ZKQ-PAF-ABT-491
33.33Single6B73PubChem 1319551386B73-κ-PubChem 131955138
33.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
33.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
33.33Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
33.33Single6TODEMPA6TOD-OX1-EMPA-Na
33.33Single6TPJSuvorexant6TPJ-OX2-Suvorexant
33.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
33.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
33.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
33.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
33.33Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
33.33Single7F8XNN90567F8X-CCKA-NN9056
33.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
33.33Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
33.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
33.33Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
33.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7XRRLemborexant7XRR-OX2-Lemborexant
33.33Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
33.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
33.33Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGVEpinephrine8GGV-β2-Epinephrine
33.33Single8GGWEpinephrine8GGW-β2-Epinephrine
33.33Single8GGXEpinephrine8GGX-β2-Epinephrine
33.33Single8GH0Epinephrine8GH0-β2-Epinephrine
33.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
33.33Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8IWESpermidine8IWE-TAAR9-Spermidine
33.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
33.33Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
33.33Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
33.33Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
33.33Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
33.33Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
33.33Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
33.33Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
33.33Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
33.33Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
33.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
33.33Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
32.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
32.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
32.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
31.82Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
31.82Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
31.82Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
31.82Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.82Consensussst_offOrthosteric Ligandsst2_off
31.58Single4AMIBucindolol4AMI-β1-Bucindolol
31.58Single4LDEBI1671074LDE-β2-BI167107
31.58Single5X33BIIL2605X33-BLT1-BIIL260
31.58Single6A93Risperidone6A93-5-HT2A-Risperidone
31.58Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
31.58Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
31.58Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
31.58Single6OS2TRV0266OS2-AT1-TRV026
31.58Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
31.58Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
31.58Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
31.58Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
31.58Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
31.58Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
31.58Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single7YITNalfurafine7YIT-κ-Nalfurafine
31.58Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
31.58Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
31.58Single8JJLOlodaterol8JJL-β2-Olodaterol
31.58Single8JWZAB9288JWZ-A2A-AB928-Na
31.58Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
31.58Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
31.58Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
31.58Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
31.58Consensusdp_offOrthosteric Liganddp2_off
31.58Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
31.58Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
31.58Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
31.58Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
31.58Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
31.58Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
31.25Single2YDOAdenosine2YDO-A2A-Adenosine
31.25Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
31.25Single6IQLL7458706IQL-D4-L745870
31.25Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
31.25Single6PS4ICI 118-5516PS4-β2-ICI 118-551
31.25Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
31.25Single6TP3Nemorexant6TP3-OX1-Nemorexant
31.25Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
31.25Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
31.25Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
31.25Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.25Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
31.25Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
31.25Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GGIEpinephrine8GGI-β2-Epinephrine
31.25Single8GGQEpinephrine8GGQ-β2-Epinephrine
31.25Single8GGTEpinephrine8GGT-β2-Epinephrine
31.25Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
31.25Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
31.25Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
31.25Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
31.25Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
31.25Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
31.25Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
30.77Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
30.77Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
30.43Single7XNACYN1548067XNA-SST2-CYN154806
30.43Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
30.43Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
30.43Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
30.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
30.00Single6H7LDobutamine6H7L-β1-Dobutamine
30.00Single6IBLArformoterol6IBL-β1-Arformoterol
30.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
30.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
30.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
30.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
30.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
30.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
30.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
30.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
30.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
30.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
30.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
30.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusorexin_onOrthosteric Ligandox2_on
30.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
29.63Single6IGLIRL16206IGL-ETB-IRL1620
29.63Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
29.41Single3NY8ICI 118-5513NY8-β2-ICI 118-551
29.41Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
29.41Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
29.41Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
29.41Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
29.41Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
29.41Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
29.41Single6D27CAY104716D27-DP2-CAY10471
29.41Single6DRXLisuride6DRX-5-HT2B-Lisuride
29.41Single6GPSMK08126GPS-CCR2-MK0812
29.41Single6H7MSalbutamol6H7M-β1-Salbutamol
29.41Single6IIVDaltroban6IIV-TP-Daltroban
29.41Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
29.41Single6PS1Timolol6PS1-β2-Timolol
29.41Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
29.41Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
29.41Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
29.41Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
29.41Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
29.41Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
29.41Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
29.41Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
29.41Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
29.41Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
29.41Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
29.41Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
29.41Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
29.41Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
29.41Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
29.41Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
29.41Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
29.41Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
29.41Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GGJEpinephrine8GGJ-β2-Epinephrine
29.41Single8GGNEpinephrine8GGN-β2-Epinephrine
29.41Single8GGOEpinephrine8GGO-β2-Epinephrine
29.41Single8GGUEpinephrine8GGU-β2-Epinephrine
29.41Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
29.41Single8JJOAlprenolol8JJO-β2-Alprenolol
29.41Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
29.41Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
29.41Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
29.41Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
29.41Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
29.41Consensusadenosine_onOrthosteric Liganda1_on a2_on
29.41Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
29.41Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
29.41Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
29.41Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
29.41Consensusblt_onOrthosteric Ligandblt1_on
29.41Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
29.41Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
29.41Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
29.41Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
29.41Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
29.41Consensusleuko_onOrthosteric Ligandblt_on
29.41Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
29.41Consensusnucleotide_onOrthosteric Ligandadenosine_on
29.41Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
29.41Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
29.17Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
29.17Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
29.17Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
29.17Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
28.57Single4UG2CGS216804UG2-A2A-CGS21680
28.57Single5ZTYAM102575ZTY-CB2-AM10257
28.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.57Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
28.57Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
28.57Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
28.57Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
28.57Single8GGREpinephrine8GGR-β2-Epinephrine
28.57Single8GGZEpinephrine8GGZ-β2-Epinephrine
28.57Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8X5YAstemizole8X5Y-H1-Astemizole
28.57Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
28.57Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
28.57Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
28.57Consensuslpl_offOrthosteric Ligands1p_off lpa_off
28.57Consensuslpl_onOrthosteric Ligands1p_on lpa_on
28.57Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
28.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
28.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
28.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
28.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
28.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
28.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
28.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
28.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
27.78Single2Y00Dobutamine2Y00-β1-Dobutamine
27.78Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
27.78Single5C1MBU725C1M-μ-BU72
27.78Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
27.78Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
27.78Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
27.78Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
27.78Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
27.78Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
27.78Single6GPXMK08126GPX-CCR2-MK0812
27.78Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
27.78Single6LUQHaloperidol6LUQ-D2-Haloperidol
27.78Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
27.78Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
27.78Single6PS6Timolol6PS6-β2-Timolol
27.78Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
27.78Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
27.78Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
27.78Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
27.78Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
27.78Single7XKAEpinephrine7XKA-β2-Epinephrine
27.78Single7YXAONO-54306087YXA-S1P5-ONO-5430608
27.78Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
27.78Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
27.78Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
27.78Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
27.78Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
27.78Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
27.78Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
27.78Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
27.78Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
27.78Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
27.78Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
27.78Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
27.78Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
27.78Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
27.78Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
27.78Consensusep_offOrthosteric Ligandep4_off
27.78Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
27.78Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
27.78Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single4IARErgotamine4IAR-5-HT1B-Ergotamine
27.27Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
27.27Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
27.27Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
27.27Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
27.27Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
27.27Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
27.27Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
27.27Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
27.27Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
27.27Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
26.92Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
26.92Single6FJ3PTH6FJ3-PTH1-PTH
26.92Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
26.92Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
26.92Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
26.92Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
26.92Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
26.67Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
26.67Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
26.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
26.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.67Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
26.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
26.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
26.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
26.67Single8GGSEpinephrine8GGS-β2-Epinephrine
26.67Single8GGYEpinephrine8GGY-β2-Epinephrine
26.67Single8GH1Epinephrine8GH1-β2-Epinephrine
26.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
26.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
26.67Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
26.67Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
26.67Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
26.32Single2YDVNECA2YDV-A2A-NECA
26.32Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
26.32Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
26.32Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
26.32Single4UHRCGS216804UHR-A2A-CGS21680
26.32Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
26.32Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
26.32Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
26.32Single5G53NECA5G53-A2A-NECA-Gs
26.32Single5X93K-87945X93-ETB-K-8794
26.32Single5XR8AM8415XR8-CB1-AM841
26.32Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
26.32Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
26.32Single6WGTLSD6WGT-5-HT2A-LSD
26.32Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
26.32Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
26.32Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
26.32Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
26.32Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
26.32Single7TUYGSK682753A7TUY-GPR183-GSK682753A
26.32Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
26.32Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
26.32Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
26.32Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
26.32Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
26.32Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
26.32Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
26.32Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
26.32Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.32Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
26.32Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
26.32Consensus5ht5_offOrthosteric Ligand5ht5a_off
26.32Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
26.32Consensusa2_onOrthosteric Liganda2a_on a2b_on
26.32Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
26.32Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
26.32Consensuschemerin_onOrthosteric Ligandcml1_on
26.32Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
26.32Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.32Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
26.32Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
26.32Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
26.09Single3QAKUK-4320973QAK-A2A-UK-432097
26.09Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
26.09Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
26.09Single7SK5CXCL127SK5-ACKR3-CXCL12
26.09Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.09Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
25.93Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
25.93Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.93Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
25.93Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
25.81Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
25.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
25.00Single5WF5UK-4320975WF5-A2A-UK-432097
25.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
25.00Single6AKXA4R6AKX-CCR5-A4R
25.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
25.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
25.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.00Single6IIURamatroban6IIU-TP-Ramatroban
25.00Single6KUXRS-799486KUX-α2a-RS-79948
25.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
25.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
25.00Single6MXTSalmeterol6MXT-β2-Salmeterol
25.00Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
25.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
25.00Single6PT2KGCHM076PT2-δ-KGCHM07
25.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.00Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
25.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
25.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
25.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
25.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
25.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
25.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
25.00Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
25.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
25.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
25.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
25.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
25.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.00Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
25.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
25.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
25.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
25.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
25.00Single8JJ8Formoterol8JJ8-β2-Formoterol
25.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
25.00Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
25.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
25.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
25.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
25.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
25.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
25.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
25.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
25.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
25.00Consensuschemokine_offOrthosteric Ligandcxcr_off
25.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
25.00Consensuscxcr_offOrthosteric Ligandcxcr4_off
25.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
25.00Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
25.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
25.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
25.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
25.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
25.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
25.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
25.00Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
25.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
24.14Single5GLHEndothelin-15GLH-ETB-Endothelin-1
24.14Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
24.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
24.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
24.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
24.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
23.81Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
23.81Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
23.81Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
23.81Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
23.81Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
23.81Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
23.81Single6K1QIRL25006K1Q-ETB-IRL2500
23.81Single7EZCUKA7EZC-A2A-UKA
23.81Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.81Single7UM4AS26747237UM4-5-HT5A-AS2674723
23.81Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
23.81Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
23.81Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
23.81Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
23.81Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
23.81Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
23.81Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
23.81Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
23.81Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.81Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
23.53Single4MBSMaraviroc4MBS-CCR5-Maraviroc
23.53Single6DS0Ly2660976DS0-5-HT2B-Ly266097
23.53Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
23.53Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
23.53Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.53Single6VI4JDTic6VI4-κ-JDTic
23.53Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
23.53Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
23.53Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
23.53Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
23.53Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
23.53Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
23.53Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
23.53Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
23.53Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
23.53Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
23.53Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
23.53Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.53Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
23.53Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8GGKEpinephrine8GGK-β2-Epinephrine
23.53Single8GGMEpinephrine8GGM-β2-Epinephrine
23.53Single8GGPEpinephrine8GGP-β2-Epinephrine
23.53Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8K2WAMG4878K2W-CXCR3-AMG487
23.53Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
23.53Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
23.53Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
23.53Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
23.53Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
23.33Consensusglp_onOrthosteric Ligandglp1_on glp2_on
23.08Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
23.08Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
23.08Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
23.08Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
23.08Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
23.08Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
23.08Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
23.08Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
22.73Single3NY9PubChem 9131033NY9-β2-PubChem 913103
22.73Single5EE7MK08935EE7-Glucagon-MK0893
22.73Single5WF6UK-4320975WF6-A2A-UK-432097
22.73Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.73Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
22.73Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
22.73Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
22.73Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
22.73Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
22.73Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
22.73Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
22.58Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
22.22Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
22.22Single2Y01Dobutamine2Y01-β1-Dobutamine
22.22Single2Y02Carmoterol2Y02-β1-Carmoterol
22.22Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
22.22Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
22.22Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
22.22Single4EJ4Naltrindole4EJ4-δ-Naltrindole
22.22Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
22.22Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
22.22Single5TGZAM65385TGZ-CB1-AM6538
22.22Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
22.22Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
22.22Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
22.22Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
22.22Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
22.22Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
22.22Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
22.22Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
22.22Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
22.22Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
22.22Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
22.22Single7BU7BI1671077BU7-β1-BI167107
22.22Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
22.22Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
22.22Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
22.22Single7F83PF-051904577F83-Ghrelin-PF-05190457
22.22Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
22.22Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
22.22Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
22.22Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
22.22Single7SK3CXCL127SK3-ACKR3-CXCL12
22.22Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
22.22Single7WC7Lisuride7WC7-5-HT2A-Lisuride
22.22Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
22.22Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
22.22Single8CU6LJ-45178CU6-A2A-LJ-4517
22.22Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
22.22Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
22.22Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
22.22Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
22.22Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
22.22Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
22.22Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
22.22Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
22.22Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
22.22Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
22.22Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
22.22Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
22.22Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
22.22Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensushistamine_onOrthosteric Ligandh1_on h4_on
22.22Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
22.22Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
22.22Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
22.22Consensustar_onOrthosteric Ligandta1_on
21.88Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.88Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.88Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.88Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
21.74Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
21.74Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
21.74Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
21.74Consensusclass-d_offOrthosteric Ligandste2_off
21.74Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
21.74Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
21.43Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.43Single6TQ9SB-4081246TQ9-OX1-SB-408124
21.43Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
21.43Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
21.43Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
21.43Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.43Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
21.43Consensusendothelin_onOrthosteric Ligandetb_on eta_on
21.43Consensussensory_onOrthosteric Ligandopsin_on
21.43Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.05Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
21.05Single5CGCHTL142425CGC-mGlu5-HTL14242
21.05Single5N2SPSB365N2S-A1-PSB36
21.05Single5TVNLSD5TVN-5-HT2B-LSD
21.05Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
21.05Single6E67BI1671076E67-β2-BI167107-Gs (fused)
21.05Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
21.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
21.05Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
21.05Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.05Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
21.05Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
21.05Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
21.05Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
21.05Single7WC6LSD7WC6-5-HT2A-LSD
21.05Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
21.05Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
21.05Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
21.05Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
21.05Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
21.05Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
21.05Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
21.05Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
21.05Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
21.05Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
21.05Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
21.05Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
21.05Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
20.83Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
20.83Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
20.83Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
20.83Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
20.83Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
20.69Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
20.69Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
20.69Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.69Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single3OE0CVX153OE0-CXCR4-CVX15
20.00Single3P0GBI1671073P0G-β2-BI167107
20.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
20.00Single3UZAGTPL92363UZA-A2A-GTPL9236
20.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
20.00Single4U15Tiotropium4U15-M3-Tiotropium
20.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
20.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
20.00Single5XRAAM115425XRA-CB1-AM11542
20.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
20.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
20.00Single6J20Aprepitant6J20-NK1-Aprepitant
20.00Single6J21Aprepitant6J21-NK1-Aprepitant
20.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
20.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
20.00Single6OL9Tiotropium6OL9-M5-Tiotropium
20.00Single6OS1TRV0266OS1-AT1-TRV026
20.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.00Single6W25SHU91196W25-MC4-SHU9119-Ca
20.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
20.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
20.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
20.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
20.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
20.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
20.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
20.00Single7W41PD1762527W41-BB2-PD176252
20.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
20.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
20.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
20.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
20.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
20.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
20.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
20.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
20.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
20.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
20.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
20.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
20.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
20.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
20.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
20.00Consensusbombesin_offOrthosteric Ligandbb2_off
20.00Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
20.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.00Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
20.00Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
20.00Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
20.00Consensushistamine_offOrthosteric Ligandh1_off
20.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
20.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
20.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
20.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
19.44Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
19.35Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
19.35Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
19.35Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
19.35Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
19.35Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.35Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.35Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
19.23Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
19.23Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.23Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.23Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
19.23Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
19.23Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.23Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
19.23Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
19.05Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
19.05Single4N4WSANT-14N4W-SMO-SANT-1
19.05Single4XEENeurotensin4XEE-NTS1-Neurotensin
19.05Single4XESNeurotensin4XES-NTS1-Neurotensin
19.05Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
19.05Single5CXVTiotropium5CXV-M1-Tiotropium
19.05Single6CM4Risperidone6CM4-D2-Risperidone
19.05Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
19.05Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
19.05Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
19.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
19.05Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
19.05Single6YVRNTS8-136YVR-NTS1-NTS8-13
19.05Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
19.05Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
19.05Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
19.05Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
19.05Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
19.05Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
19.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
19.05Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
19.05Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
19.05Consensusgi_class-fOther Ligandgi_frizzled
19.05Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
19.05Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
19.05Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
19.05Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
19.05Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
18.75Single3PBLEticlopride3PBL-D3-Eticlopride
18.75Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
18.75Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
18.75Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
18.75Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.75Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
18.75Single7SRQLSD7SRQ-5-HT2B-LSD
18.75Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.75Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
18.75Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
18.75Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
18.75Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
18.75Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
18.75Consensusclass-t_onOrthosteric Ligandtaste2_on
18.75Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
18.75Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Consensusgs_class-tOrthosteric Ligandgs_taste
18.75Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.75Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
18.75Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.52Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.52Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
18.52Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
18.52Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
18.52Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.52Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single4BUONeurotensin4BUO-NTS1-Neurotensin
18.18Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
18.18Single5CGDHTL142425CGD-mGlu5-HTL14242
18.18Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
18.18Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
18.18Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
18.18Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
18.18Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
18.18Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
18.18Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
18.18Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
18.18Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
18.18Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
18.18Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
18.18Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
18.18Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
18.18Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.18Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
17.86Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
17.86Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
17.86Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
17.86Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
17.86Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
17.65Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
17.65Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
17.65Single3PWHZM2413853PWH-A2A-ZM241385
17.65Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
17.65Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
17.65Single7F8YDevazepide7F8Y-CCKA-Devazepide
17.65Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
17.65Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
17.65Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
17.65Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
17.65Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
17.65Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
17.65Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
17.65Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
17.65Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
17.65Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
17.65Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
17.65Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
17.65Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
17.65Consensusgt_class-aOrthosteric Ligandgt_opsin
17.65Consensusgt_opsinOrthosteric Ligandgt_sensory
17.65Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Consensusmglu_onOther Ligandmglu2_on mglu4_on
17.65Consensuspth_onOrthosteric Ligandpth1_on pth2_on
17.39Single6PT3DPI-2876PT3-δ-DPI-287
17.39Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
17.39Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
17.39Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusclass-d_offOrthosteric Ligandste2_off
17.39Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
17.24Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
17.24Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.24Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
17.24Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
17.24Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.24Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
17.24Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.24Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
17.24Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.24Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
17.24Consensusgo_class-b1Orthosteric Ligandgo_crf
17.24Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.24Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.67Single3REYPubChem 56973REY-A2A-PubChem 5697
16.67Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
16.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
16.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
16.67Single6A94Zotepine6A94-5-HT2A-Zotepine
16.67Single6LMLGlucagon6LML-Glucagon-Glucagon
16.67Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
16.67Single6MH8ZM2413856MH8-A2A-ZM241385
16.67Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single6TPKRetosiban6TPK-OT-Retosiban
16.67Single6TPNHTL66416TPN-OX2-HTL6641
16.67Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
16.67Single7AROLUF58337ARO-A2A-LUF5833-Na
16.67Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
16.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
16.67Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
16.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
16.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
16.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
16.67Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
16.67Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
16.67Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.67Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
16.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
16.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
16.67Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
16.67Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
16.67Single8GGLEpinephrine8GGL-β2-Epinephrine
16.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8IY6Endothelin-18IY6-ETB-Endothelin-1
16.67Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
16.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
16.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
16.67Consensus5ht5_onOrthosteric Ligand5ht5a_on
16.67Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.67Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
16.67Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
16.67Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.67Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
16.67Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
16.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
16.67Consensusvasopressin-ot_offOrthosteric Ligandot_off
16.13Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.00Single6HLOAprepitant6HLO-NK1-Aprepitant
16.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
16.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
16.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
16.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
16.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
15.79Single4DAJTiotropium4DAJ-M3-Tiotropium
15.79Single4MQSIperoxo4MQS-M2-Iperoxo
15.79Single4U14Tiotropium4U14-M3-Tiotropium
15.79Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
15.79Single5DSGTiotropium5DSG-M4-Tiotropium
15.79Single5T04Neurotensin5T04-NTS1-Neurotensin
15.79Single5UENDU1725UEN-A1-DU172
15.79Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
15.79Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
15.79Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
15.79Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
15.79Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
15.79Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
15.79Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
15.79Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
15.79Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
15.79Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
15.79Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
15.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
15.79Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
15.79Single8X63Mepyramine8X63-H1-Mepyramine
15.79Single8X64Desloratadine8X64-H1-Desloratadine
15.79Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
15.79Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
15.79Consensuscck_offOrthosteric Ligandccka_off
15.79Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
15.79Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.79Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
15.79Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
15.62Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
15.62Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
15.38Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.38Single6W25Ca6W25-MC4-SHU9119-Ca
15.38Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.38Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.15Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
15.15Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.15Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.15Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
15.00Single5XPRBosentan5XPR-ETB-Bosentan
15.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
15.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
15.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
15.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
15.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
15.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single8EA0Iperoxo8EA0-M3-Iperoxo
15.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
15.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
15.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
15.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
15.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
15.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
14.81Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensusclass-d_onOrthosteric Ligandste2_on
14.81Consensusgi_class-dOrthosteric Ligandgi_ste
14.81Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
14.29Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
14.29Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
14.29Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
14.29Single4BV0Neurotensin4BV0-NTS1-Neurotensin
14.29Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
14.29Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
14.29Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
14.29Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.29Single6E59L-7607356E59-NK1-L-760735
14.29Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.29Single7EPENAM5637EPE-mGlu-NAM563
14.29Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
14.29Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
14.29Single7P2L4YI7P2L-mGlu5-4YI
14.29Single7PX4PSB-21137PX4-A2A-PSB-2113
14.29Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
14.29Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
14.29Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
14.29Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
14.29Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
14.29Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
14.29Single8PWNTheophylline8PWN-A2A-Theophylline
14.29Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
14.29Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
14.29Consensusadenosine_offOrthosteric Liganda1_off a2_off
14.29Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.29Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
14.29Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Consensuslpa_offOrthosteric Ligandlpa1_off
14.29Consensuslpa_onOrthosteric Ligandlpa1_on
14.29Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
14.29Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
14.29Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
14.29Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
14.29Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.79Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusclass-d_onOrthosteric Ligandste2_on
13.79Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.79Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.64Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
13.64Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.64Single6HLPNetupitant6HLP-NK1-Netupitant
13.64Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.64Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
13.64Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
13.64Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
13.64Consensusclass-b2_onOrthosteric Ligandadgrg_on
13.33Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
13.33Single3RFMCaffeine3RFM-A2A-Caffeine
13.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.33Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.33Single8A2OTheophylline8A2O-A2A-Theophylline-Na
13.33Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
13.33Consensusgi_class-dOrthosteric Ligandgi_ste
13.33Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.16Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.04Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.04Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
13.04Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.04Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
13.04Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.90Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
12.90Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
12.82Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
12.50Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
12.50Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
12.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.50Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
12.50Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
12.50Single6ME5Agomelatine6ME5-MT1-Agomelatine
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
12.50Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
12.50Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
12.50Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
12.50Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
12.50Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50Single7WC5Psilocin7WC5-5-HT2A-Psilocin
12.50Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.50Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
12.50Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusgs_class-b2Orthosteric Ligandgs_adgr
12.50Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
12.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
12.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
12.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
11.76Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.76Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
11.76Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
11.76Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
11.76Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
11.76Single5L7IVismodegib5L7I-SMO-Vismodegib
11.76Single6HLLCP999946HLL-NK1-CP99994
11.76Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
11.76Single6TP4ACT-4622066TP4-OX1-ACT-462206
11.76Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.76Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.76Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
11.76Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
11.76Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
11.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.76Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.76Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.76Consensusgo_class-b2Orthosteric Ligandgo_adhesion
11.76Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.54Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
11.11Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
11.11Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.11Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
11.11Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.11Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single5K2DZM2413855K2D-A2A-ZM241385
11.11Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
11.11Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6JZHZM2413856JZH-A2A-ZM241385-Na
11.11Single6ME2Ramelteon6ME2-MT1-Ramelteon
11.11Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
11.11Single6PS7ZM2413856PS7-A2A-ZM241385-Na
11.11Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
11.11Single7F8ULintitript7F8U-CCKA-Lintitript
11.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
11.11Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
11.11Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
11.11Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
11.11Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
11.11Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
11.11Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
11.11Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
11.11Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
10.71Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.71Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.53Single3RZECidoxepin3RZE-H1-Cidoxepin
10.53Single5IU4ZM2413855IU4-A2A-ZM241385-Na
10.53Single5IU7Q274563465IU7-A2A-Q27456346-Na
10.53Single5IUBQ274563445IUB-A2A-Q27456344-Na
10.53Single5JTBZM2413855JTB-A2A-ZM241385
10.53Single5K2BZM2413855K2B-A2A-ZM241385-Na
10.53Single5K2CZM2413855K2C-A2A-ZM241385-Na
10.53Single5NLXZM2413855NLX-A2A-ZM241385-Na
10.53Single5NM4ZM2413855NM4-A2A-ZM241385-Na
10.53Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
10.53Single6AQFZM2413856AQF-A2A-ZM241385
10.53Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.53Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
10.53Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
10.53Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.53Single7T32ZM2413857T32-A2A-ZM241385
10.53Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
10.53Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.53Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.53Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
10.53Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
10.53Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
10.53Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.53Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.53Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
10.53Consensusgnrh_offOrthosteric Ligandgnrh1_off
10.53Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensussensory_offOrthosteric Ligandopsin_off
10.34Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
10.00Single3EMLZM2413853EML-A2A-ZM241385
10.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
10.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
10.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
10.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
10.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
10.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
10.00Single6FFHFenobam6FFH-mGlu5-Fenobam
10.00Single6LPJZM2413856LPJ-A2A-ZM241385-Na
10.00Single6LPKZM2413856LPK-A2A-ZM241385-Na
10.00Single6S0LZM2413856S0L-A2A-ZM241385
10.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
10.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7PYRPSB-21157PYR-A2A-PSB-2115
10.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
10.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
10.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
10.00Consensusa2_offOrthosteric Liganda2a_off
10.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
10.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
10.00Consensustachykinin_offOrthosteric Ligandnk1_off
9.68Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
9.52Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
9.52Single5IUAQ274563485IUA-A2A-Q27456348-Na
9.52Single5NM2ZM2413855NM2-A2A-ZM241385-Na
9.52Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.52Single6LPLZM2413856LPL-A2A-ZM241385-Na
9.52Single6S0QZM2413856S0Q-A2A-ZM241385
9.52Single6WQAZM2413856WQA-A2A-ZM241385-Na
9.52Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
9.52Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
9.52Single7RM5ZM2413857RM5-A2A-ZM241385-Na
9.52Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.52Single8FYNZM2413858FYN-A2A-ZM241385-Na
9.52Single8QOTNanobody E8QOT-μ-Nanobody E
9.38Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
9.38Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
9.09Single5TZR-5TZR-FFA1 (GPR40)-MK8666
9.09Single5V56TC1145V56-SMO-TC114
9.09Single5V57TC1145V57-SMO-TC114
9.09Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
9.09Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
9.09Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
9.09Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.09Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
9.09Single7F1TMIP-1a7F1T-CCR5-MIP-1a
9.09Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
9.09Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
9.09Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
9.09Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Consensusclass-c_offOther Ligandgabab_off mglu_off
9.09Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
8.70Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
8.70Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
8.70Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
8.70Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.70Consensusnts_offOrthosteric Ligandnts1_off
8.70Consensusnts_onOrthosteric Ligandnts1_on
8.70Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
8.33Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
8.33Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.33Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
8.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
8.33Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single6KNMJN241-96KNM-Apelin-JN241-9
8.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
7.89Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.69Single8HS2Fab0468HS2-GPR20-Fab046
7.41Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
7.14Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
7.14Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
7.14Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
6.67Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
6.67Consensusclass-c_onOther Ligandgabab_on mglu_on
6.45Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.25Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
6.25Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.25Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
6.06Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.88Single6LI0GTPL98046LI0-GPR52-GTPL9804
5.88Single6ME9Ramelteon6ME9-MT2-Ramelteon
5.88Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.88Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
5.88Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.88Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
5.88Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
5.88Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.88Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.71Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.56Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.56Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
5.56Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
5.56Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
5.41Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.41Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.26Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
5.26Single4QINSAG1.54QIN-SMO-SAG1.5
5.26Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.26Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.26Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
5.26Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
5.26Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.26Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.13Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.00Single5UVIZM2413855UVI-A2A-ZM241385
5.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.00Single6ZINSR486926ZIN-NTS1-SR48692
5.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
5.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
5.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
5.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
5.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
5.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.88Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.76Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.76Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.76Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
4.55Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
4.55Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
4.55Single6Z4SSR486926Z4S-NTS1-SR48692
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.55Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.35Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.35Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
4.35Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
4.35Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.17Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.17Single7SHEPI; PE7SHE-GPR158-PI; PE
4.17Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.17Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
4.17Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
4.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.70Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
3.57Single7SHEPI; PE7SHE-GPR158-PI; PE
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.57Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.86Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.86Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3

PDB Summary
PDB 8I7W
Class A
SubFamily Alicarboxylic acid
Type Hydroxycarboxylic acid
SubType HCA2
Species Homo Sapiens
Ligand GSK256073
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.39
Date 2024-02-07
D.O.I. 10.1038/s41467-023-42764-8
Net Summary
Imin 2.87
Number of Linked Nodes 803
Number of Links 945
Number of Hubs 146
Number of Links mediated by Hubs 540
Number of Communities 30
Number of Nodes involved in Communities 202
Number of Links involved in Communities 274
Path Summary
Number Of Nodes in MetaPath 117
Number Of Links MetaPath 116
Number of Shortest Paths 15575327
Length Of Smallest Path 3
Average Path Length 61.8612
Length of Longest Path 84
Minimum Path Strength 1.41
Average Path Strength 6.45562
Maximum Path Strength 22.33
Minimum Path Correlation 0.71
Average Path Correlation 0.998256
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.36986
Average % Of Corr. Nodes 25.4989
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.2229
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeOKL
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeOKL
Name8-chloranyl-3-pentyl-7H-purine-2,6-dione
Synonyms
Identifier8-chloranyl-3-pentyl-7~{H}-purine-2,6-dione
FormulaC10 H13 Cl N4 O2
Molecular Weight256.689
SMILESCCCCCN1c2c([nH]c(n2)Cl)C(=O)NC1=O
PubChem46215799
Formal Charge0
Total Atoms30
Total Chiral Atoms0
Total Bonds31
Total Aromatic Bonds5

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8TDS4
Sequence
>8I7W_Chain_R
HFLEIDKKN CCVFRDDFI VKVLPPVLG LEFIFGLLG NGLALWIFC 
FHLKSWKSS RIFLFNLAV ADFLLIICL PFLMDNYVR RWDWKFGDI 
PCRLMLFML AMNRQGSII FLTVVAVDR YFRVVHPHH ALNKISNRT 
AAIISCLLW GITIGLTVH LLKKKMPIQ NGGANLCSS FSICHTFQW 
HEAMFLLEF FLPLGIILF CSARIIWSL RQRQMDRHA KIKRAITFI 
MVVAIVFVI CFLPSVVVR IRIFWLLHT SGTQNCEVY RSVDLAFFI 
TLSFTYMNS MLDPVVYYF SSP


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8I7W_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG AGESGKSTI 
VKQMKITGI VETHFTFKD LHFKMFDVG GQRSERKKW IHCFEGVTA 
IIFCVESMK LFDSICNNK WFTDTSIIL FLNKKEIYT HFTCATDTK 
NVQFVFDAV TDVIIKNNL KDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8I7W_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8I7W_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XK2AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;23.12023-02-2210.1038/s41467-023-37177-6
7ZL9AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiens---2.72023-04-1210.1038/s41467-023-37177-6
7ZLYAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiens---2.72023-04-1210.1038/s41467-023-37177-6
8H2GAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/&β;1/&γ;23.012023-10-11To be published
8I7VAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcipimox-Gi1/&β;1/&γ;22.772024-02-0710.1038/s41467-023-42764-8
8IHBAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073-Gi1/&β;1/&γ;22.852023-09-1310.1038/s41467-023-41650-7
8IHFAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;22.972023-08-3010.1038/s41467-023-41650-7
8IHHAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensLUF6283-Gi1/&β;1/&γ;23.062023-08-3010.1038/s41467-023-41650-7
8IHIAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcifran-Gi1/&β;1/&γ;23.112023-08-3010.1038/s41467-023-41650-7
8IJ3AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiens--Gi1/&β;1/&γ;23.282024-01-0310.1038/s41421-023-00610-7
8IJAAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/&β;1/&γ;22.692024-01-0310.1038/s41421-023-00610-7
8IJBAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcipimox-Gi1/&β;1/&γ;23.232024-01-0310.1038/s41421-023-00610-7
8IJDAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;23.252024-01-0310.1038/s41421-023-00610-7
8IY9AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Go/&β;1/&γ;23.372024-03-0610.1038/s41467-024-46239-2
8IYHAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Go/&β;1/&γ;23.32024-03-0610.1038/s41467-024-46239-2
8IYWAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073-Go/&β;1/&γ;23.452024-03-0610.1038/s41467-024-46239-2
8J6IAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;22.922024-04-0310.1016/j.celrep.2023.113406
8J6JAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073-Gi1/&β;1/&γ;22.82024-01-1010.1016/j.celrep.2023.113406
8J6LAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/&β;1/&γ;23.052024-04-0310.1016/j.celrep.2023.113406
8J6PAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacinCompound 9nGi1/&β;1/&γ;22.552023-12-0610.1038/s41467-023-43537-z
8J6QAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensBeta-hydroxybutyrateCompound 9nGi1/&β;1/&γ;22.62023-12-0610.1038/s41467-023-43537-z
8J6RAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;22.762023-12-0610.1038/s41467-023-43537-z
8JERAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcipimox-Go/&β;1/&γ;23.452024-03-0610.1038/s41467-024-46239-2
8JHNAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMMF-Go/&β;1/&γ;23.752024-03-0610.1038/s41467-024-46239-2
8JHYAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiens-Compound 9nGi1/&β;1/&γ;22.872023-09-0610.1016/j.molcel.2023.07.030
8JIIAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacinCompound 9nGi1/&β;1/&γ;23.172023-09-0610.1016/j.molcel.2023.07.030
8JILAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/&β;1/&γ;23.52023-09-0610.1016/j.molcel.2023.07.030
8JIMAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMMF-Gi1/&β;1/&γ;22.982023-09-0610.1016/j.molcel.2023.07.030
8JZ7AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;22.62023-10-0410.1038/s41392-023-01625-y
8K5BAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin--3.432023-11-2210.1038/s41467-023-42764-8
8K5CAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcipimox--3.132023-11-2210.1038/s41467-023-42764-8
8K5DAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073--3.742023-11-2210.1038/s41467-023-42764-8




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