psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F21	R:R:H9	12.44	Yes	No	6	2	6
2	R:R:H9	R:R:R270	5.64	No	No	6	6	1
3	R:R:E12	R:R:F10	5.83	No	No	0	5	7
4	R:R:F10	R:R:N17	8.46	No	No	0	7	5
5	R:R:I13	R:R:L11	4.28	No	No	1	3	8
6	R:R:I169	R:R:L11	4.28	No	No	1	1	8
7	R:R:L11	R:R:N171	6.87	No	No	0	8	1
8	R:R:I13	R:R:K16	4.36	No	Yes	1	3	4
9	R:R:I13	R:R:I169	8.83	No	No	1	3	1
10	R:R:D14	R:R:K16	5.53	No	Yes	0	5	4
11	R:R:C183	R:R:K16	4.85	No	Yes	0	1	4
12	R:R:K16	R:R:T185	4.5	Yes	No	1	4	2
13	R:R:K16	R:R:Q187	5.42	Yes	No	1	4	2
14	R:R:C18	R:R:C183	7.28	No	No	0	9	1
15	R:R:C19	R:R:C266	7.28	No	No	0	4	7
16	R:R:L176	R:R:V20	4.47	Yes	No	0	4	2
17	R:R:F21	R:R:R270	5.34	Yes	No	6	2	1
18	R:R:D273	R:R:F21	8.36	No	Yes	0	4	2
19	R:R:R22	R:R:R90	21.32	Yes	No	0	3	4
20	R:R:R22	R:R:W91	7	Yes	Yes	0	3	4
21	R:R:D92	R:R:R22	10.72	No	Yes	0	4	3
22	R:R:A174	R:R:R22	6.91	No	Yes	0	2	3
23	R:R:D23	R:R:F25	7.17	No	No	1	4	6
24	R:R:D23	R:R:L274	5.43	No	Yes	1	4	1
25	R:R:D24	R:R:R90	5.96	No	No	0	4	4
26	R:R:F25	R:R:L274	4.87	No	Yes	1	6	1
27	R:R:I26	R:R:L30	7.14	Yes	No	1	5	5
28	R:R:I26	R:R:Y87	4.84	Yes	Yes	1	5	6
29	R:R:I26	R:R:W91	7.05	Yes	Yes	1	5	4
30	R:R:I278	R:R:V29	4.61	No	No	0	6	5
31	R:R:L30	R:R:Y87	17.58	No	Yes	1	5	6
32	R:R:P31	R:R:P32	5.84	No	No	0	6	5
33	R:R:P31	R:R:V88	5.3	No	No	0	6	3
34	R:R:L34	R:R:M84	4.24	No	No	0	8	7
35	R:R:E37	R:R:Y284	4.49	Yes	Yes	0	7	7
36	R:R:E37	R:R:M285	6.77	Yes	No	0	7	5
37	R:R:E37	R:R:M288	5.41	Yes	No	0	7	8
38	R:R:F38	R:R:L42	7.31	Yes	No	0	7	7
39	R:R:F38	R:R:L80	4.87	Yes	No	0	7	8
40	R:R:F38	R:R:P81	10.11	Yes	No	0	7	8
41	R:R:F40	R:R:I39	7.54	No	No	0	6	5
42	R:R:F40	R:R:M288	4.98	No	No	0	6	8
43	R:R:G44	R:R:P291	4.06	No	No	0	7	9
44	R:R:D73	R:R:N45	6.73	Yes	No	0	9	9
45	R:R:N45	R:R:P291	9.77	No	No	0	9	9
46	R:R:F296	R:R:L47	7.31	No	No	0	8	6
47	R:R:A48	R:R:Y295	5.34	No	Yes	0	9	7
48	R:R:F74	R:R:L49	4.87	No	No	0	7	7
49	R:R:F54	R:R:W50	19.04	No	No	0	4	4
50	R:R:H55	R:R:W50	4.23	No	No	0	5	4
51	R:R:H55	R:R:I51	13.26	No	No	0	5	7
52	R:R:F301	R:R:I51	12.56	Yes	No	0	9	7
53	R:R:F52	R:R:L56	4.87	Yes	No	0	7	5
54	R:R:F52	R:R:F67	7.5	Yes	No	0	7	6
55	R:R:F52	R:R:Y295	12.38	Yes	Yes	3	7	7
56	R:R:F301	R:R:F52	12.86	Yes	Yes	3	9	7
57	R:R:C53	R:R:F54	8.38	No	No	0	4	4
58	R:R:I64	R:R:W59	4.7	No	No	0	7	6
59	R:R:I139	R:R:S61	6.19	No	No	0	7	6
60	R:R:D124	R:R:S62	7.36	No	No	7	8	8
61	R:R:R128	R:R:S62	5.27	No	No	7	8	8
62	R:R:R63	R:R:S298	6.59	No	No	0	7	8
63	R:R:R63	R:R:S300	5.27	No	No	0	7	5
64	R:R:F301	R:R:R63	6.41	Yes	No	0	9	7
65	R:R:I64	R:R:N141	5.66	No	No	0	7	2
66	R:R:A144	R:R:I64	4.87	No	No	0	7	7
67	R:R:F65	R:R:V120	9.18	No	No	0	7	7
68	R:R:L66	R:R:V121	4.47	No	No	0	8	9
69	R:R:L66	R:R:Y294	4.69	No	Yes	0	8	9
70	R:R:L66	R:R:Y295	5.86	No	Yes	0	8	7
71	R:R:F117	R:R:N68	13.29	No	No	2	8	9
72	R:R:N68	R:R:S148	5.96	No	No	0	9	8
73	R:R:N68	R:R:W152	7.91	No	Yes	2	9	9
74	R:R:D73	R:R:L69	8.14	Yes	Yes	0	9	9
75	R:R:L118	R:R:L69	5.54	No	Yes	3	9	9
76	R:R:L69	R:R:Y294	7.03	Yes	Yes	3	9	9
77	R:R:L69	R:R:Y295	4.69	Yes	Yes	3	9	7
78	R:R:D73	R:R:S114	7.36	Yes	No	0	9	9
79	R:R:D73	R:R:S287	8.83	Yes	No	0	9	8
80	R:R:D290	R:R:D73	11.98	Yes	Yes	0	9	9
81	R:R:F74	R:R:I78	8.79	No	No	0	7	6
82	R:R:L75	R:R:M106	4.24	No	No	2	6	5
83	R:R:L75	R:R:N110	12.36	No	No	2	6	9
84	R:R:L107	R:R:L76	4.15	Yes	No	1	6	7
85	R:R:L76	R:R:Y284	4.69	No	Yes	1	7	7
86	R:R:L76	R:R:S287	6.01	No	No	0	7	8
87	R:R:C79	R:R:M106	4.86	No	No	0	6	5
88	R:R:L80	R:R:Y284	7.03	No	Yes	0	8	7
89	R:R:L83	R:R:Y87	7.03	No	Yes	1	6	6
90	R:R:L83	R:R:M103	5.65	No	Yes	1	6	5
91	R:R:L107	R:R:L83	6.92	Yes	No	1	6	6
92	R:R:D85	R:R:R89	7.15	No	No	0	4	4
93	R:R:D85	R:R:F95	8.36	No	No	0	4	7
94	R:R:N86	R:R:W91	4.52	No	Yes	0	5	4
95	R:R:N86	R:R:W93	7.91	No	Yes	0	5	9
96	R:R:W91	R:R:Y87	13.5	Yes	Yes	1	4	6
97	R:R:D92	R:R:R89	5.96	No	No	0	4	4
98	R:R:L176	R:R:W91	4.56	Yes	Yes	1	4	4
99	R:R:S178	R:R:W91	4.94	No	Yes	1	4	4
100	R:R:F277	R:R:W91	14.03	No	Yes	0	5	4
101	R:R:F95	R:R:W93	20.04	No	Yes	0	7	9
102	R:R:C100	R:R:W93	11.75	No	Yes	1	9	9
103	R:R:M103	R:R:W93	5.82	Yes	Yes	1	5	9
104	R:R:C177	R:R:W93	20.89	No	Yes	1	9	9
105	R:R:G96	R:R:P99	4.06	No	No	0	7	5
106	R:R:D97	R:R:R101	13.1	No	No	0	3	6
107	R:R:D97	R:R:K166	4.15	No	No	0	3	4
108	R:R:I98	R:R:R101	6.26	No	No	0	2	6
109	R:R:C100	R:R:M167	4.86	No	No	0	9	3
110	R:R:C100	R:R:C177	7.28	No	No	1	9	9
111	R:R:L107	R:R:M103	5.65	Yes	Yes	1	6	5
112	R:R:L104	R:R:M167	4.24	No	No	0	5	3
113	R:R:C177	R:R:L104	4.76	No	No	0	9	5
114	R:R:L104	R:R:S179	7.51	No	No	0	5	4
115	R:R:F105	R:R:M109	8.71	Yes	Yes	2	6	5
116	R:R:F105	R:R:T159	6.49	Yes	No	2	6	7
117	R:R:F105	R:R:V160	5.24	Yes	No	0	6	4
118	R:R:F105	R:R:L163	17.05	Yes	No	0	6	5
119	R:R:M106	R:R:N110	5.61	No	No	2	5	9
120	R:R:L107	R:R:Y284	5.86	Yes	Yes	1	6	7
121	L:L:?1	R:R:L107	6.44	Yes	Yes	1	0	6
122	R:R:M109	R:R:N110	7.01	Yes	No	2	5	9
123	R:R:M109	R:R:T155	6.02	Yes	No	0	5	7
124	R:R:I156	R:R:M109	4.37	No	Yes	0	4	5
125	R:R:M109	R:R:T159	9.03	Yes	No	2	5	7
126	R:R:F180	R:R:R111	5.34	Yes	Yes	1	3	8
127	R:R:E196	R:R:R111	9.3	No	Yes	0	5	8
128	R:R:R111	R:R:T283	6.47	Yes	No	0	8	8
129	L:L:?1	R:R:R111	10.17	Yes	Yes	1	0	8
130	R:R:Q112	R:R:T155	5.67	Yes	No	0	7	7
131	R:R:L158	R:R:Q112	7.99	No	Yes	0	5	7
132	R:R:M192	R:R:Q112	9.52	No	Yes	0	5	7
133	R:R:E196	R:R:Q112	8.92	No	Yes	0	5	7
134	R:R:E196	R:R:I115	6.83	No	No	0	5	8
135	R:R:F240	R:R:I115	5.02	Yes	No	8	9	8
136	R:R:F244	R:R:I115	8.79	Yes	No	8	8	8
137	R:R:I116	R:R:L151	5.71	No	Yes	0	5	7
138	R:R:F117	R:R:L151	4.87	No	Yes	0	8	7
139	R:R:F117	R:R:W152	12.03	No	Yes	2	8	9
140	R:R:D290	R:R:L118	5.43	Yes	No	3	9	9
141	R:R:L118	R:R:Y294	8.21	No	Yes	3	9	9
142	R:R:P200	R:R:T119	6.99	No	No	0	9	7
143	R:R:I203	R:R:T119	4.56	No	No	0	7	7
144	R:R:I204	R:R:T119	4.56	No	No	0	8	7
145	R:R:R125	R:R:V121	7.85	No	No	0	9	9
146	R:R:D124	R:R:R128	11.91	No	No	7	8	8
147	R:R:R125	R:R:Y294	5.14	No	Yes	0	9	9
148	R:R:V130	R:R:Y126	12.62	Yes	Yes	5	8	7
149	R:R:H131	R:R:Y126	7.62	Yes	Yes	5	7	7
150	R:R:F206	R:R:Y126	9.28	No	Yes	5	4	7
151	R:R:C207	R:R:Y126	8.06	Yes	Yes	0	8	7
152	R:R:R210	R:R:Y126	13.38	No	Yes	5	4	7
153	R:R:F127	R:R:H131	5.66	Yes	Yes	0	5	7
154	R:R:F127	R:R:H134	10.18	Yes	No	0	5	4
155	R:R:F127	R:R:L136	9.74	Yes	No	0	5	4
156	R:R:N137	R:R:R128	7.23	No	No	0	4	8
157	R:R:I211	R:R:V129	7.68	No	No	0	8	8
158	R:R:H131	R:R:V130	11.07	Yes	Yes	5	7	8
159	R:R:R210	R:R:V130	5.23	No	Yes	5	4	8
160	R:R:S214	R:R:V130	6.46	No	Yes	0	5	8
161	R:R:H133	R:R:P132	4.58	No	No	0	6	8
162	R:R:I139	R:R:T143	7.6	No	No	0	7	3
163	R:R:S140	R:R:T143	4.8	No	No	0	6	3
164	R:R:L158	R:R:W188	9.11	No	No	0	5	5
165	R:R:H161	R:R:L162	10.29	Yes	No	1	7	4
166	R:R:H161	R:R:W188	7.41	Yes	No	0	7	5
167	R:R:H161	R:R:H189	7.17	Yes	Yes	1	7	5
168	R:R:H189	R:R:L162	7.71	Yes	No	1	5	4
169	R:R:N175	R:R:P168	11.4	No	No	0	4	4
170	R:R:I169	R:R:L176	12.85	No	Yes	1	1	4
171	R:R:L176	R:R:N171	5.49	Yes	No	0	4	1
172	R:R:L176	R:R:S178	7.51	Yes	No	1	4	4
173	R:R:H189	R:R:S179	5.58	Yes	No	0	5	4
174	L:L:?1	R:R:S179	9.78	Yes	No	0	0	4
175	R:R:F180	R:R:H189	9.05	Yes	Yes	1	3	5
176	R:R:E190	R:R:F180	4.66	Yes	Yes	1	4	3
177	R:R:F180	R:R:F193	12.86	Yes	No	1	3	6
178	R:R:F180	R:R:R251	4.28	Yes	Yes	1	3	5
179	R:R:F180	R:R:F276	15	Yes	Yes	1	3	4
180	L:L:?1	R:R:F180	11.33	Yes	Yes	1	0	3
181	R:R:I182	R:R:I254	11.77	Yes	No	0	3	4
182	R:R:I182	R:R:L258	4.28	Yes	No	1	3	3
183	R:R:I182	R:R:Y269	4.84	Yes	Yes	1	3	2
184	R:R:D273	R:R:I182	5.6	No	Yes	0	4	3
185	R:R:H184	W:W:?1	11.23	No	Yes	0	3	0
186	R:R:Q187	R:R:T185	4.25	No	No	1	2	2
187	R:R:F186	W:W:?1	20.4	No	Yes	0	4	0
188	R:R:E190	R:R:Q187	7.65	Yes	No	1	4	2
189	R:R:M192	R:R:W188	10.47	No	No	0	5	5
190	R:R:E190	R:R:R251	10.47	Yes	Yes	1	4	5
191	R:R:E190	R:R:F255	5.83	Yes	Yes	1	4	5
192	R:R:E190	W:W:?1	10.61	Yes	Yes	1	4	0
193	R:R:F193	R:R:S247	6.61	No	No	0	6	6
194	R:R:F193	R:R:F276	5.36	No	Yes	1	6	4
195	R:R:F255	R:R:L194	6.09	Yes	No	1	5	4
196	R:R:L194	W:W:?1	5.04	No	Yes	1	4	0
197	R:R:L195	W:W:?1	4.03	No	Yes	0	4	0
198	R:R:F197	R:R:F198	9.65	Yes	No	0	8	5
199	R:R:F197	R:R:L201	12.18	Yes	No	0	8	7
200	R:R:F197	R:R:F240	4.29	Yes	Yes	0	8	9
201	R:R:F197	R:R:L245	7.31	Yes	No	0	8	6
202	R:R:F197	R:R:V248	10.49	Yes	No	0	8	8
203	R:R:I203	R:R:L199	4.28	No	No	0	7	4
204	R:R:L201	R:R:L205	5.54	No	No	0	7	4
205	R:R:F240	R:R:I204	6.28	Yes	No	0	9	8
206	R:R:F206	R:R:R210	9.62	No	No	5	4	4
207	R:R:I212	R:R:R216	7.52	Yes	No	0	5	4
208	R:R:I212	R:R:I230	5.89	Yes	No	4	5	6
209	R:R:Q217	R:R:W213	18.62	No	No	0	5	3
210	R:R:L215	R:R:M220	4.24	Yes	No	4	8	3
211	R:R:I226	R:R:L215	5.71	No	Yes	4	6	8
212	R:R:I230	R:R:L215	5.71	No	Yes	4	6	8
213	R:R:D221	R:R:R216	10.72	No	No	0	3	4
214	R:R:M220	R:R:R218	4.96	No	No	0	3	5
215	R:R:I226	R:R:M220	4.37	No	No	4	6	3
216	R:R:H223	R:R:K225	7.86	No	No	0	4	5
217	R:R:F232	R:R:R228	4.28	No	No	0	7	7
218	R:R:F232	R:R:S297	11.89	No	No	0	7	6
219	R:R:V236	R:R:Y294	11.36	No	Yes	0	8	9
220	R:R:F240	R:R:F244	9.65	Yes	Yes	8	9	8
221	R:R:C243	R:R:N286	7.87	No	No	0	8	9
222	R:R:F244	R:R:T283	9.08	Yes	No	0	8	8
223	R:R:F244	R:R:N286	8.46	Yes	No	0	8	9
224	R:R:F282	R:R:P246	5.78	No	No	0	7	9
225	R:R:T279	R:R:V250	4.76	No	No	0	7	5
226	R:R:I254	R:R:R251	11.27	No	Yes	0	4	5
227	R:R:F255	R:R:R251	7.48	Yes	Yes	1	5	5
228	R:R:F276	R:R:R251	19.24	Yes	Yes	1	4	5
229	R:R:L257	R:R:R253	13.36	No	No	0	3	5
230	R:R:I254	R:R:V272	4.61	No	No	0	4	4
231	R:R:F255	W:W:?1	30.15	Yes	Yes	1	5	0
232	R:R:T260	R:R:W256	8.49	No	No	0	1	4
233	R:R:L257	R:R:Y269	7.03	No	Yes	0	3	2
234	R:R:L257	R:R:V272	4.47	No	No	0	3	4
235	R:R:L258	R:R:Y269	8.21	No	Yes	1	3	2
236	R:R:L258	W:W:?1	8.06	No	Yes	1	3	0
237	R:R:E267	R:R:R270	9.3	No	No	0	2	1
238	R:R:D273	R:R:F277	10.75	No	No	0	4	5
239	R:R:I278	R:R:L274	4.28	No	Yes	0	6	1
240	R:R:F276	R:R:F277	5.36	Yes	No	0	4	5
241	R:R:F282	R:R:T279	5.19	No	No	0	7	7
242	L:L:?1	R:R:L280	6.44	Yes	No	0	0	5
243	L:L:?1	R:R:Y284	6.54	Yes	Yes	1	0	7
244	R:R:L289	R:R:M285	4.24	No	No	0	7	5
245	R:R:D290	R:R:N286	12.12	Yes	No	0	9	9
246	R:R:D290	R:R:Y294	5.75	Yes	Yes	3	9	9
247	R:R:F296	R:R:P291	4.33	No	No	0	8	9
248	R:R:F301	R:R:Y295	6.19	Yes	Yes	3	9	7
249	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
250	R:R:E37	R:R:L34	3.98	Yes	No	0	7	8
251	R:R:H223	R:R:I226	3.98	No	No	0	4	6
252	R:R:N175	R:R:Q170	3.96	No	No	0	4	1
253	R:R:F67	R:R:V71	3.93	No	No	0	6	6
254	R:R:H161	R:R:K165	3.93	Yes	No	0	7	4
255	R:R:D8	R:R:E267	3.9	No	No	0	6	2
256	R:R:H55	R:R:N302	3.83	No	No	0	5	8
257	R:R:V268	R:R:Y269	3.79	No	Yes	0	1	2
258	R:R:V293	R:R:Y294	3.79	No	Yes	0	8	9
259	R:R:F38	R:R:I77	3.77	Yes	No	0	7	6
260	R:R:F282	R:R:M285	3.73	No	No	0	7	5
261	R:R:K94	R:R:R89	3.71	No	No	0	3	4
262	R:R:F67	R:R:L49	3.65	No	No	0	6	7
263	R:R:G113	R:R:T155	3.64	No	No	0	7	7
264	R:R:F127	R:R:N137	3.62	Yes	No	0	5	4
265	R:R:P299	R:R:S298	3.56	No	No	0	5	8
266	R:R:G41	R:R:I77	3.53	No	No	0	8	6
267	R:R:G153	R:R:I156	3.53	No	No	0	4	4
268	R:R:M109	R:R:W152	3.49	Yes	Yes	2	5	9
269	R:R:C207	R:R:V123	3.42	Yes	No	0	8	6
270	R:R:I98	R:R:P99	3.39	No	No	0	2	5
271	R:R:A275	R:R:V250	3.39	No	No	0	5	5
272	R:R:S181	R:R:V20	3.23	No	No	0	4	2
273	R:R:S281	R:R:V33	3.23	No	No	0	6	5
274	R:R:V235	R:R:V293	3.21	No	No	0	5	8
275	R:R:I233	R:R:S208	3.1	No	No	0	7	8
276	R:R:K164	R:R:V160	3.04	No	No	0	4	4
277	R:R:L30	R:R:S281	3	No	No	0	5	6
278	R:R:L34	R:R:S281	3	No	No	0	8	6
279	R:R:R253	R:R:W256	3	No	No	0	5	4
280	R:R:L151	R:R:V120	2.98	Yes	No	0	7	7
281	R:R:L215	R:R:V129	2.98	Yes	No	0	8	8
282	R:R:L245	R:R:V241	2.98	No	No	0	6	5
283	R:R:L245	R:R:V249	2.98	No	No	0	6	6
284	R:R:I212	R:R:I233	2.94	Yes	No	0	5	7
285	R:R:I212	R:R:M234	2.92	Yes	No	4	5	4
286	R:R:I230	R:R:M234	2.92	No	No	4	6	4
287	R:R:F95	R:R:P99	2.89	No	No	0	7	5
288	R:R:I26	R:R:L274	2.85	Yes	Yes	1	5	1
289	R:R:I98	R:R:L102	2.85	No	No	0	2	5
290	R:R:I146	R:R:L150	2.85	No	No	0	3	4
291	R:R:I147	R:R:L151	2.85	No	Yes	0	5	7
292	R:R:I154	R:R:L158	2.85	No	No	0	5	5
293	R:R:I252	R:R:L194	2.85	No	No	0	6	4
294	R:R:C266	R:R:F21	2.79	No	Yes	0	7	2
295	R:R:P31	R:R:Y87	2.78	No	Yes	0	6	6
296	R:R:D24	R:R:K28	2.77	No	No	0	4	3
297	R:R:A144	R:R:F65	2.77	No	No	0	7	7
298	R:R:H184	R:R:T263	2.74	No	No	0	3	3
299	R:R:E267	R:R:N265	2.63	No	No	0	2	5
300	R:R:R90	R:R:V27	2.62	No	No	0	4	3
301	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
302	R:R:I146	R:R:R142	2.51	No	No	0	3	4
303	R:R:F82	R:R:M103	2.49	No	Yes	0	6	5
304	R:R:F40	R:R:L36	2.44	No	No	0	6	4
305	R:R:A191	W:W:?1	2.29	No	Yes	0	3	0
306	R:R:H259	R:R:W256	2.12	No	No	0	1	4
307	R:R:G172	R:R:G173	2.11	No	No	0	3	4
308	R:R:G262	R:R:S261	1.86	No	No	0	4	3
309	R:R:G157	R:R:V160	1.84	No	No	0	5	4
310	R:R:A122	R:R:C207	1.81	No	Yes	0	9	8
311	R:R:G35	R:R:M84	1.75	No	No	0	5	7
312	R:R:G44	R:R:L43	1.71	No	No	0	7	4
313	R:R:G46	R:R:L49	1.71	No	No	0	4	7
314	R:R:A144	R:R:S61	1.71	No	No	0	7	6
315	R:R:G202	R:R:L201	1.71	No	No	0	3	7
316	R:R:A237	R:R:S208	1.71	No	No	0	7	8
317	R:R:C243	R:R:V239	1.71	No	No	0	8	7
318	R:R:A108	R:R:T159	1.68	No	No	0	4	7
319	R:R:C207	R:R:I203	1.64	Yes	No	0	8	7
320	R:R:C243	R:R:I242	1.64	No	No	0	8	5
321	R:R:G262	R:R:Q264	1.64	No	No	0	4	3
322	R:R:S214	R:R:V129	1.62	No	No	0	5	8
323	R:R:A237	R:R:I204	1.62	No	No	0	7	8
324	R:R:S271	R:R:V272	1.62	No	No	0	3	4
325	R:R:S261	R:R:T260	1.6	No	No	0	3	1
326	R:R:T231	R:R:V235	1.59	No	No	0	6	5
327	R:R:K57	R:R:S58	1.53	No	No	0	5	6
328	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
329	R:R:I238	R:R:I242	1.47	No	No	0	5	5
330	R:R:N17	R:R:T263	1.46	No	No	0	5	3
331	R:R:P299	R:R:R228	1.44	No	No	0	5	7
332	R:R:P168	R:R:W93	1.35	No	Yes	0	4	9
333	R:R:R142	R:R:S140	1.32	No	No	0	4	6
334	R:R:F296	R:R:V292	1.31	No	No	0	8	6
335	R:R:S214	R:R:W213	1.24	No	No	0	5	3
336	R:R:Q219	R:R:R222	1.17	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:K16	4.932	5	1	4
2	R:R:F21	7.2325	4	6	2
3	R:R:R22	11.4875	4	0	3
4	R:R:I26	5.47	4	1	5
5	R:R:E37	5.1625	4	0	7
6	R:R:F38	6.515	4	0	7
7	R:R:F52	9.4025	4	3	7
8	R:R:L69	6.35	4	3	9
9	R:R:D73	8.608	5	0	9
10	R:R:Y87	9.146	5	1	6
11	R:R:W91	7.94286	7	1	4
12	R:R:W93	11.2933	6	1	9
13	R:R:M103	4.9025	4	1	5
14	R:R:F105	9.3725	4	2	6
15	R:R:L107	5.804	5	1	6
16	R:R:M109	6.43833	6	2	5
17	R:R:R111	7.82	4	1	8
18	R:R:Q112	8.025	4	0	7
19	R:R:Y126	10.192	5	5	7
20	R:R:F127	7.3	4	0	5
21	R:R:V130	8.845	4	5	8
22	R:R:H131	6.47	4	5	7
23	R:R:L151	4.1025	4	0	7
24	R:R:W152	6.505	4	2	9
25	R:R:H161	7.2	4	1	7
26	R:R:L176	6.976	5	1	4
27	R:R:F180	8.93143	7	1	3
28	R:R:I182	6.6225	4	1	3
29	R:R:H189	7.3775	4	1	5
30	R:R:E190	7.844	5	1	4
31	R:R:F197	8.784	5	0	8
32	R:R:C207	3.7325	4	0	8
33	R:R:I212	4.8175	4	4	5
34	R:R:L215	4.66	4	4	8
35	R:R:F240	6.31	4	8	9
36	R:R:F244	8.995	4	8	8
37	R:R:R251	10.548	5	1	5
38	R:R:F255	12.3875	4	1	5
39	R:R:Y269	5.9675	4	1	2
40	R:R:L274	4.3575	4	1	1
41	R:R:F276	11.24	4	1	4
42	R:R:Y284	5.722	5	1	7
43	R:R:D290	8.82	4	3	9
44	R:R:Y294	6.56714	7	3	9
45	R:R:Y295	6.41	6	3	7
46	R:R:F301	9.505	4	3	9
47	W:W:?1	11.4762	8	1	0
48	L:L:?1	8.45	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H184	W:W:?1	11.4552	11.23	No	Yes	0	3	0
2	R:R:D273	R:R:F21	16.8727	8.36	No	Yes	0	4	2
3	R:R:D273	R:R:F277	21.9633	10.75	No	No	0	4	5
4	R:R:F277	R:R:W91	34.2094	14.03	No	Yes	0	5	4
5	R:R:L176	R:R:W91	12.5255	4.56	Yes	Yes	1	4	4
6	R:R:I254	R:R:R251	21.4424	11.27	No	Yes	0	4	5
7	R:R:E190	R:R:Q187	14.4812	7.65	Yes	No	1	4	2
8	R:R:K16	R:R:Q187	10.7165	5.42	Yes	No	1	4	2
9	R:R:E190	W:W:?1	24.3264	10.61	Yes	Yes	1	4	0
10	R:R:E190	R:R:F180	38.8976	4.66	Yes	Yes	1	4	3
11	R:R:F180	R:R:F276	34.1668	15	Yes	Yes	1	3	4
12	R:R:F276	R:R:F277	38.4003	5.36	Yes	No	0	4	5
13	R:R:R22	R:R:W91	16.6217	7	Yes	Yes	0	3	4
14	R:R:I26	R:R:L274	12.8759	2.85	Yes	Yes	1	5	1
15	R:R:I26	R:R:W91	10.7828	7.05	Yes	Yes	1	5	4
16	R:R:W91	R:R:Y87	13.5673	13.5	Yes	Yes	1	4	6
17	R:R:E37	R:R:Y284	26.6136	4.49	Yes	Yes	0	7	7
18	L:L:?1	R:R:Y284	39.6032	6.54	Yes	Yes	1	0	7
19	L:L:?1	R:R:F180	32.9356	11.33	Yes	Yes	1	0	3
20	R:R:E37	R:R:M285	13.1884	6.77	Yes	No	0	7	5
21	R:R:L80	R:R:Y284	10.3376	7.03	No	Yes	0	8	7
22	R:R:L83	R:R:Y87	22.1764	7.03	No	Yes	1	6	6
23	R:R:L107	R:R:L83	22.257	6.92	Yes	No	1	6	6
24	R:R:L107	R:R:L76	30.3547	4.15	Yes	No	1	6	7
25	R:R:L76	R:R:S287	49.6046	6.01	No	No	0	7	8
26	R:R:D73	R:R:S287	48.6622	8.83	Yes	No	0	9	8
27	R:R:D73	R:R:N45	12.9232	6.73	Yes	No	0	9	9
28	R:R:N45	R:R:P291	11.1048	9.77	No	No	0	9	9
29	L:L:?1	R:R:L107	41.5258	6.44	Yes	Yes	1	0	6
30	R:R:L76	R:R:Y284	21.2104	4.69	No	Yes	1	7	7
31	R:R:L69	R:R:Y295	67.3675	4.69	Yes	Yes	3	9	7
32	R:R:D73	R:R:L69	47.2605	8.14	Yes	Yes	0	9	9
33	R:R:F52	R:R:Y295	25.7328	12.38	Yes	Yes	3	7	7
34	R:R:F52	R:R:F67	19.9839	7.5	Yes	No	0	7	6
35	R:R:F67	R:R:L49	13.3589	3.65	No	No	0	6	7
36	R:R:F301	R:R:Y295	45.1343	6.19	Yes	Yes	3	9	7
37	R:R:F301	R:R:I51	20.0407	12.56	Yes	No	0	9	7
38	R:R:H55	R:R:I51	16.7353	13.26	No	No	0	5	7
39	R:R:H55	R:R:W50	10.0677	4.23	No	No	0	5	4
40	R:R:F180	R:R:R111	65.4118	5.34	Yes	Yes	1	3	8
41	R:R:E196	R:R:R111	69.006	9.3	No	Yes	0	5	8
42	R:R:E196	R:R:Q112	67.6943	8.92	No	Yes	0	5	7
43	R:R:Q112	R:R:T155	61.2113	5.67	Yes	No	0	7	7
44	R:R:M109	R:R:T155	58.2185	6.02	Yes	No	0	5	7
45	R:R:M109	R:R:W152	36.2078	3.49	Yes	Yes	2	5	9
46	R:R:F117	R:R:W152	29.5354	12.03	No	Yes	2	8	9
47	R:R:F117	R:R:L151	28.0106	4.87	No	Yes	0	8	7
48	R:R:L151	R:R:V120	22.9057	2.98	Yes	No	0	7	7
49	R:R:F65	R:R:V120	21.1867	9.18	No	No	0	7	7
50	R:R:A144	R:R:F65	19.463	2.77	No	No	0	7	7
51	R:R:A144	R:R:S61	12.4544	1.71	No	No	0	7	6
52	R:R:I139	R:R:S61	10.6786	6.19	No	No	0	7	6
53	R:R:F127	R:R:H131	17.351	5.66	Yes	Yes	0	5	7
54	R:R:H131	R:R:Y126	23.8907	7.62	Yes	Yes	5	7	7
55	R:R:C207	R:R:Y126	45.3379	8.06	Yes	Yes	0	8	7
56	R:R:C207	R:R:I203	52.1286	1.64	Yes	No	0	8	7
57	R:R:I203	R:R:T119	56.6652	4.56	No	No	0	7	7
58	R:R:I204	R:R:T119	61.2303	4.56	No	No	0	8	7
59	R:R:F240	R:R:I204	100	6.28	Yes	No	0	9	8
60	R:R:F240	R:R:I115	50.2581	5.02	Yes	No	8	9	8
61	R:R:E196	R:R:I115	77.6625	6.83	No	No	0	5	8
62	R:R:F240	R:R:F244	70.7629	9.65	Yes	Yes	8	9	8
63	R:R:F244	R:R:T283	46.7585	9.08	Yes	No	0	8	8
64	R:R:R111	R:R:T283	46.8343	6.47	Yes	No	0	8	8
65	R:R:F301	R:R:R63	22.721	6.41	Yes	No	0	9	7
66	R:R:R63	R:R:S298	16.3896	6.59	No	No	0	7	8
67	R:R:F244	R:R:N286	67.8695	8.46	Yes	No	0	8	9
68	R:R:D290	R:R:N286	66.2121	12.12	Yes	No	0	9	9
69	R:R:D290	R:R:Y294	36.383	5.75	Yes	Yes	3	9	9
70	R:R:L66	R:R:Y294	16.4512	4.69	No	Yes	0	8	9
71	R:R:D290	R:R:L118	14.3439	5.43	Yes	No	3	9	9
72	R:R:F95	R:R:W93	18.4685	20.04	No	Yes	0	7	9
73	R:R:F95	R:R:P99	12.7575	2.89	No	No	0	7	5
74	L:L:?1	R:R:S179	10.0961	9.78	Yes	No	0	0	4
75	R:R:V130	R:R:Y126	14.5191	12.62	Yes	Yes	5	8	7
76	R:R:S214	R:R:V130	13.1316	6.46	No	Yes	0	5	8
77	R:R:A237	R:R:I204	37.6663	1.62	No	No	0	7	8
78	R:R:A237	R:R:S208	35.2702	1.71	No	No	0	7	8
79	R:R:I233	R:R:S208	32.8882	3.1	No	No	0	7	8
80	R:R:I212	R:R:I233	30.8898	2.94	Yes	No	0	5	7
81	R:R:I212	R:R:I230	21.7124	5.89	Yes	No	4	5	6
82	R:R:I230	R:R:L215	19.5577	5.71	No	Yes	4	6	8
83	R:R:F197	R:R:F240	22.6263	4.29	Yes	Yes	0	8	9
84	R:R:P299	R:R:S298	13.07	3.56	No	No	0	5	8
85	R:R:L257	R:R:R253	13.0558	13.36	No	No	0	3	5
86	R:R:I254	R:R:V272	15.8971	4.61	No	No	0	4	4
87	R:R:R253	R:R:W256	11.2184	3	No	No	0	5	4
88	R:R:M103	R:R:W93	23.2325	5.82	Yes	Yes	1	5	9
89	R:R:L107	R:R:M103	25.0178	5.65	Yes	Yes	1	6	5
90	R:R:L257	R:R:V272	11.7015	4.47	No	No	0	3	4
91	R:R:D290	R:R:D73	24.1843	11.98	Yes	Yes	0	9	9
92	R:R:L69	R:R:Y294	17.5877	7.03	Yes	Yes	3	9	9
93	R:R:L66	R:R:Y295	14.4386	5.86	No	Yes	0	8	7
94	R:R:L118	R:R:L69	13.643	5.54	No	Yes	3	9	9
95	L:L:?1	R:R:R111	49.6614	10.17	Yes	Yes	1	0	8
96	R:R:F180	R:R:R251	24.871	4.28	Yes	Yes	1	3	5
97	R:R:F244	R:R:I115	27.3192	8.79	Yes	No	8	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E37	R:R:Y284	4.49	0	Yes	Yes	7	7	2	1
R:R:L107	R:R:L76	4.15	1	Yes	No	6	7	1	2
R:R:L76	R:R:Y284	4.69	1	No	Yes	7	7	2	1
R:R:L80	R:R:Y284	7.03	0	No	Yes	8	7	2	1
R:R:L83	R:R:M103	5.65	1	No	Yes	6	5	2	2
R:R:L107	R:R:L83	6.92	1	Yes	No	6	6	1	2
R:R:L107	R:R:M103	5.65	1	Yes	Yes	6	5	1	2
R:R:L104	R:R:S179	7.51	0	No	No	5	4	2	1
R:R:L107	R:R:Y284	5.86	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:L107	6.44	1	Yes	Yes	0	6	0	1
R:R:F180	R:R:R111	5.34	1	Yes	Yes	3	8	1	1
R:R:E196	R:R:R111	9.3	0	No	Yes	5	8	2	1
R:R:R111	R:R:T283	6.47	1	Yes	No	8	8	1	2
L:L:?1	R:R:R111	10.17	1	Yes	Yes	0	8	0	1
R:R:H189	R:R:S179	5.58	1	Yes	No	5	4	2	1
L:L:?1	R:R:S179	9.78	1	Yes	No	0	4	0	1
R:R:F180	R:R:H189	9.05	1	Yes	Yes	3	5	1	2
R:R:E190	R:R:F180	4.66	1	Yes	Yes	4	3	2	1
R:R:F180	R:R:F193	12.86	1	Yes	No	3	6	1	2
R:R:F180	R:R:R251	4.28	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	15	1	Yes	Yes	3	4	1	2
L:L:?1	R:R:F180	11.33	1	Yes	Yes	0	3	0	1
R:R:E190	R:R:R251	10.47	1	Yes	Yes	4	5	2	2
R:R:F193	R:R:F276	5.36	1	No	Yes	6	4	2	2
R:R:F276	R:R:R251	19.24	1	Yes	Yes	4	5	2	2
L:L:?1	R:R:L280	6.44	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	6.54	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E190	R:R:F180	4.66	1	Yes	Yes	4	3	1	2
R:R:F180	R:R:R251	4.28	1	Yes	Yes	3	5	2	2
R:R:I182	R:R:L258	4.28	1	Yes	No	3	3	2	1
R:R:I182	R:R:Y269	4.84	1	Yes	Yes	3	2	2	2
R:R:H184	W:W:?1	11.23	0	No	Yes	3	0	1	0
R:R:F186	W:W:?1	20.4	0	No	Yes	4	0	1	0
R:R:E190	R:R:Q187	7.65	1	Yes	No	4	2	1	2
R:R:E190	R:R:R251	10.47	1	Yes	Yes	4	5	1	2
R:R:E190	R:R:F255	5.83	1	Yes	Yes	4	5	1	1
R:R:E190	W:W:?1	10.61	1	Yes	Yes	4	0	1	0
R:R:F255	R:R:L194	6.09	1	Yes	No	5	4	1	1
R:R:L194	W:W:?1	5.04	1	No	Yes	4	0	1	0
R:R:L195	W:W:?1	4.03	0	No	Yes	4	0	1	0
R:R:F255	R:R:R251	7.48	1	Yes	Yes	5	5	1	2
R:R:F255	W:W:?1	30.15	1	Yes	Yes	5	0	1	0
R:R:L258	R:R:Y269	8.21	1	No	Yes	3	2	1	2
R:R:L258	W:W:?1	8.06	1	No	Yes	3	0	1	0
R:R:I252	R:R:L194	2.85	0	No	No	6	4	2	1
R:R:H184	R:R:T263	2.74	0	No	No	3	3	1	2
R:R:A191	W:W:?1	2.29	0	No	Yes	3	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8J6Q_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.02
Number of Linked Nodes	287
Number of Links	336
Number of Hubs	48
Number of Links mediated by Hubs	179
Number of Communities	8
Number of Nodes involved in Communities	75
Number of Links involved in Communities	101

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	67697
Length Of Smallest Path	3
Average Path Length	12.7513
Length of Longest Path	31
Minimum Path Strength	1.43
Average Path Strength	6.95185
Maximum Path Strength	25.275
Minimum Path Correlation	0.7
Average Path Correlation	0.920206
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	49.4804
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.5977
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • myeloid cell apoptotic process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • protein localization • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • cellular macromolecule localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • cellular localization • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • regulation of cellular localization • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	IX8
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	IX8
Name	7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide
Synonyms
Identifier
Formula	C26 H28 N4 O2
Molecular Weight	428.526
SMILES
PubChem	25101223
Formal Charge	0
Total Atoms	60
Total Chiral Atoms	1
Total Bonds	63
Total Aromatic Bonds	22


Code	3HR
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	3HR
Name	(3R)-3-hydroxybutanoic acid
Synonyms
Identifier
Formula	C4 H8 O3
Molecular Weight	104.105
SMILES
PubChem	92135
Formal Charge	0
Total Atoms	15
Total Chiral Atoms	1
Total Bonds	14
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8J6Q_nogp_Chain_R D H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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