| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8J6P | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo Sapiens | Niacin | Compound 9n | Gi1/Beta1/Gamma2 | 2.55 | 2023-12-06 | 10.1038/s41467-023-43537-z |
|
A 2D representation of the interactions of IX8 in 8J6P
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:E190 | R:R:F180 | 4.66 | 2 | Yes | Yes | 4 | 3 | 1 | 2 | | R:R:F180 | R:R:R251 | 3.21 | 2 | Yes | Yes | 3 | 5 | 2 | 2 | | R:R:I182 | R:R:I254 | 10.3 | 2 | Yes | Yes | 3 | 4 | 2 | 2 | | R:R:I182 | R:R:L258 | 4.28 | 2 | Yes | Yes | 3 | 3 | 2 | 1 | | R:R:I182 | R:R:Y269 | 6.04 | 2 | Yes | Yes | 3 | 2 | 2 | 2 | | R:R:G262 | R:R:H184 | 3.18 | 0 | No | No | 4 | 3 | 2 | 1 | | R:R:H184 | R:R:T263 | 6.85 | 0 | No | No | 3 | 3 | 1 | 2 | | R:R:H184 | W:W:?1 | 14.04 | 0 | No | Yes | 3 | 0 | 1 | 0 | | R:R:F186 | W:W:?1 | 9.76 | 0 | No | Yes | 4 | 0 | 1 | 0 | | R:R:E190 | R:R:R251 | 11.63 | 2 | Yes | Yes | 4 | 5 | 1 | 2 | | R:R:E190 | R:R:F255 | 5.83 | 2 | Yes | Yes | 4 | 5 | 1 | 1 | | R:R:E190 | W:W:?1 | 8.68 | 2 | Yes | Yes | 4 | 0 | 1 | 0 | | R:R:A191 | W:W:?1 | 3.44 | 0 | No | Yes | 3 | 0 | 1 | 0 | | R:R:I252 | R:R:L194 | 4.28 | 0 | No | No | 6 | 4 | 2 | 1 | | R:R:F255 | R:R:L194 | 7.31 | 2 | Yes | No | 5 | 4 | 1 | 1 | | R:R:L194 | W:W:?1 | 11.09 | 2 | No | Yes | 4 | 0 | 1 | 0 | | R:R:L195 | W:W:?1 | 3.02 | 0 | No | Yes | 4 | 0 | 1 | 0 | | R:R:F197 | R:R:F198 | 10.72 | 2 | Yes | No | 8 | 5 | 2 | 1 | | R:R:F197 | R:R:V248 | 9.18 | 2 | Yes | No | 8 | 8 | 2 | 2 | | R:R:F198 | R:R:V248 | 3.93 | 2 | No | No | 5 | 8 | 1 | 2 | | R:R:F198 | W:W:?1 | 4.43 | 2 | No | Yes | 5 | 0 | 1 | 0 | | R:R:I254 | R:R:R251 | 6.26 | 2 | Yes | Yes | 4 | 5 | 2 | 2 | | R:R:F255 | R:R:R251 | 10.69 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:I254 | R:R:L258 | 2.85 | 2 | Yes | Yes | 4 | 3 | 2 | 1 | | R:R:F255 | W:W:?1 | 28.38 | 2 | Yes | Yes | 5 | 0 | 1 | 0 | | R:R:L258 | R:R:Y269 | 8.21 | 2 | Yes | Yes | 3 | 2 | 1 | 2 | | R:R:L258 | W:W:?1 | 11.09 | 2 | Yes | Yes | 3 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 10.44 | | Average Nodes In Shell | 20.00 | | Average Hubs In Shell | 10.00 | | Average Links In Shell | 27.00 | | Average Links Mediated by Hubs In Shell | 23.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8J6Q | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo Sapiens | Beta-Hydroxybutyrate | Compound 9n | Gi1/Beta1/Gamma2 | 2.6 | 2023-12-06 | 10.1038/s41467-023-43537-z |
|
A 2D representation of the interactions of IX8 in 8J6Q
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:E190 | R:R:F180 | 4.66 | 1 | Yes | Yes | 4 | 3 | 1 | 2 | | R:R:F180 | R:R:R251 | 4.28 | 1 | Yes | Yes | 3 | 5 | 2 | 2 | | R:R:I182 | R:R:L258 | 4.28 | 1 | Yes | Yes | 3 | 3 | 2 | 1 | | R:R:I182 | R:R:Y269 | 4.84 | 1 | Yes | Yes | 3 | 2 | 2 | 2 | | R:R:H184 | R:R:L258 | 3.86 | 1 | No | Yes | 3 | 3 | 1 | 1 | | R:R:H184 | W:W:?1 | 11.23 | 1 | No | Yes | 3 | 0 | 1 | 0 | | R:R:F186 | W:W:?1 | 20.4 | 0 | No | Yes | 4 | 0 | 1 | 0 | | R:R:E190 | R:R:Q187 | 7.65 | 1 | Yes | No | 4 | 2 | 1 | 2 | | R:R:E190 | R:R:R251 | 10.47 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | R:R:E190 | R:R:F255 | 5.83 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | | R:R:E190 | W:W:?1 | 10.61 | 1 | Yes | Yes | 4 | 0 | 1 | 0 | | R:R:F255 | R:R:L194 | 6.09 | 1 | Yes | No | 5 | 4 | 1 | 1 | | R:R:L194 | W:W:?1 | 5.04 | 1 | No | Yes | 4 | 0 | 1 | 0 | | R:R:L195 | W:W:?1 | 4.03 | 0 | No | Yes | 4 | 0 | 1 | 0 | | R:R:F255 | R:R:R251 | 7.48 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:F255 | W:W:?1 | 30.15 | 1 | Yes | Yes | 5 | 0 | 1 | 0 | | R:R:L258 | R:R:Y269 | 8.21 | 1 | Yes | Yes | 3 | 2 | 1 | 2 | | R:R:L258 | W:W:?1 | 8.06 | 1 | Yes | Yes | 3 | 0 | 1 | 0 | | R:R:I252 | R:R:L194 | 2.85 | 0 | No | No | 6 | 4 | 2 | 1 | | R:R:H184 | R:R:T263 | 2.74 | 1 | No | No | 3 | 3 | 1 | 2 | | R:R:A191 | W:W:?1 | 2.29 | 0 | No | Yes | 3 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 11.48 | | Average Nodes In Shell | 16.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 21.00 | | Average Links Mediated by Hubs In Shell | 19.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JHY | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo Sapiens | - | Compound 9n | Gi1/Beta1/Gamma2 | 2.87 | 2023-09-06 | 10.1016/j.molcel.2023.07.030 |
|
A 2D representation of the interactions of IX8 in 8JHY
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:E190 | R:R:F180 | 2.33 | 4 | Yes | Yes | 4 | 3 | 1 | 2 | | R:R:F180 | R:R:R251 | 2.14 | 4 | Yes | Yes | 3 | 5 | 2 | 2 | | R:R:I182 | R:R:L258 | 4.28 | 4 | Yes | No | 3 | 3 | 2 | 1 | | R:R:I182 | R:R:Y269 | 6.04 | 4 | Yes | Yes | 3 | 2 | 2 | 2 | | R:R:H184 | R:R:T263 | 4.11 | 0 | No | No | 3 | 3 | 1 | 2 | | R:R:H184 | W:W:?1 | 8.43 | 0 | No | Yes | 3 | 0 | 1 | 0 | | R:R:F186 | W:W:?1 | 7.98 | 0 | No | Yes | 4 | 0 | 1 | 0 | | R:R:E190 | R:R:Q187 | 2.55 | 4 | Yes | No | 4 | 2 | 1 | 2 | | R:R:E190 | R:R:R251 | 8.14 | 4 | Yes | Yes | 4 | 5 | 1 | 2 | | R:R:E190 | W:W:?1 | 13.51 | 4 | Yes | Yes | 4 | 0 | 1 | 0 | | R:R:A191 | W:W:?1 | 6.88 | 0 | No | Yes | 3 | 0 | 1 | 0 | | R:R:F255 | R:R:L194 | 2.44 | 4 | No | Yes | 5 | 4 | 1 | 1 | | R:R:L194 | W:W:?1 | 5.04 | 4 | Yes | Yes | 4 | 0 | 1 | 0 | | R:R:L195 | R:R:L199 | 2.77 | 0 | No | No | 4 | 4 | 1 | 2 | | R:R:L195 | W:W:?1 | 4.03 | 0 | No | Yes | 4 | 0 | 1 | 0 | | R:R:F197 | R:R:F198 | 7.5 | 4 | Yes | No | 8 | 5 | 2 | 1 | | R:R:F198 | W:W:?1 | 3.55 | 0 | No | Yes | 5 | 0 | 1 | 0 | | R:R:F255 | R:R:R251 | 5.34 | 4 | No | Yes | 5 | 5 | 1 | 2 | | R:R:F255 | W:W:?1 | 15.96 | 4 | No | Yes | 5 | 0 | 1 | 0 | | R:R:L258 | R:R:Y269 | 7.03 | 4 | No | Yes | 3 | 2 | 1 | 2 | | R:R:L258 | W:W:?1 | 8.06 | 4 | No | Yes | 3 | 0 | 1 | 0 | | R:R:L194 | R:R:V248 | 1.49 | 4 | Yes | No | 4 | 8 | 1 | 2 | | R:R:I252 | R:R:L194 | 1.43 | 0 | No | Yes | 6 | 4 | 2 | 1 | | R:R:A191 | R:R:W188 | 1.3 | 0 | No | No | 3 | 5 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 8.16 | | Average Nodes In Shell | 21.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 24.00 | | Average Links Mediated by Hubs In Shell | 21.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JII | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo Sapiens | Niacin | Compound 9n | Gi1/Beta1/Gamma2 | 3.17 | 2023-09-06 | 10.1016/j.molcel.2023.07.030 |
|
A 2D representation of the interactions of IX8 in 8JII
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:E190 | R:R:F180 | 7 | 2 | Yes | Yes | 4 | 3 | 1 | 2 | | R:R:I182 | R:R:I254 | 4.42 | 2 | Yes | Yes | 3 | 4 | 2 | 2 | | R:R:I182 | R:R:L258 | 4.28 | 2 | Yes | Yes | 3 | 3 | 2 | 1 | | R:R:I182 | R:R:Y269 | 4.84 | 2 | Yes | Yes | 3 | 2 | 2 | 2 | | R:R:F186 | W:W:?1 | 5.32 | 0 | No | Yes | 4 | 0 | 1 | 0 | | R:R:E190 | R:R:Q187 | 3.82 | 2 | Yes | No | 4 | 2 | 1 | 2 | | R:R:E190 | R:R:R251 | 10.47 | 2 | Yes | Yes | 4 | 5 | 1 | 2 | | R:R:E190 | R:R:F255 | 3.5 | 2 | Yes | Yes | 4 | 5 | 1 | 1 | | R:R:E190 | W:W:?1 | 7.72 | 2 | Yes | Yes | 4 | 0 | 1 | 0 | | R:R:A191 | W:W:?1 | 4.59 | 0 | No | Yes | 3 | 0 | 1 | 0 | | R:R:I252 | R:R:L194 | 2.85 | 0 | No | No | 6 | 4 | 2 | 1 | | R:R:F255 | R:R:L194 | 3.65 | 2 | Yes | No | 5 | 4 | 1 | 1 | | R:R:L194 | W:W:?1 | 3.02 | 2 | No | Yes | 4 | 0 | 1 | 0 | | R:R:L195 | W:W:?1 | 4.03 | 0 | No | Yes | 4 | 0 | 1 | 0 | | R:R:F197 | R:R:F198 | 6.43 | 2 | Yes | No | 8 | 5 | 2 | 1 | | R:R:F198 | W:W:?1 | 3.55 | 0 | No | Yes | 5 | 0 | 1 | 0 | | R:R:I254 | R:R:R251 | 2.51 | 2 | Yes | Yes | 4 | 5 | 2 | 2 | | R:R:F255 | R:R:I254 | 2.51 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | | R:R:I254 | R:R:L258 | 2.85 | 2 | Yes | Yes | 4 | 3 | 2 | 1 | | R:R:F255 | W:W:?1 | 14.19 | 2 | Yes | Yes | 5 | 0 | 1 | 0 | | R:R:L258 | R:R:Y269 | 7.03 | 2 | Yes | Yes | 3 | 2 | 1 | 2 | | R:R:L258 | W:W:?1 | 7.06 | 2 | Yes | Yes | 3 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 6.19 | | Average Nodes In Shell | 17.00 | | Average Hubs In Shell | 10.00 | | Average Links In Shell | 22.00 | | Average Links Mediated by Hubs In Shell | 21.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
