psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F10	R:R:F21	7.5	No	Yes	0	7	2
2	R:R:D14	R:R:E12	9.09	No	Yes	0	5	5
3	R:R:E12	R:R:V20	2.85	Yes	No	5	5	2
4	R:R:E12	R:R:N171	5.26	Yes	Yes	5	5	1
5	R:R:E12	R:R:L176	3.98	Yes	Yes	5	5	4
6	R:R:I13	R:R:N17	2.83	No	No	0	3	5
7	R:R:D14	R:R:I169	11.2	No	No	0	5	1
8	R:R:K15	R:R:K165	5.75	No	No	0	3	4
9	R:R:K16	R:R:T185	13.51	No	No	0	4	2
10	R:R:C18	R:R:C183	7.28	No	No	0	9	1
11	R:R:C19	R:R:F21	2.79	No	Yes	8	4	2
12	R:R:C19	R:R:C266	7.28	No	No	8	4	7
13	R:R:N171	R:R:V20	2.96	Yes	No	5	1	2
14	R:R:L176	R:R:V20	4.47	Yes	No	5	4	2
15	R:R:C266	R:R:F21	2.79	No	Yes	8	7	2
16	R:R:F21	R:R:R270	14.97	Yes	No	0	2	1
17	R:R:D273	R:R:F21	5.97	No	Yes	0	4	2
18	R:R:A174	R:R:R22	4.15	No	No	0	2	3
19	R:R:D23	R:R:R270	19.06	No	No	0	4	1
20	R:R:D24	R:R:V27	2.92	No	No	0	4	3
21	R:R:D24	R:R:R90	3.57	No	No	0	4	4
22	R:R:F25	R:R:K28	7.44	No	No	0	6	3
23	R:R:F25	R:R:V29	5.24	No	No	0	6	5
24	R:R:F25	R:R:L274	12.18	No	No	0	6	1
25	R:R:I26	R:R:L30	4.28	No	Yes	0	5	5
26	R:R:I26	R:R:Y87	6.04	No	Yes	0	5	6
27	R:R:I26	R:R:L274	2.85	No	No	0	5	1
28	R:R:L30	R:R:V29	2.98	Yes	No	0	5	5
29	R:R:I278	R:R:L30	2.85	No	Yes	0	6	5
30	R:R:P31	R:R:P32	7.79	No	No	0	6	5
31	R:R:P31	R:R:V88	3.53	No	No	0	6	3
32	R:R:E37	R:R:V33	2.85	Yes	No	10	7	5
33	R:R:S281	R:R:V33	4.85	No	No	10	6	5
34	R:R:L34	R:R:L80	2.77	No	No	0	8	8
35	R:R:F40	R:R:L36	3.65	No	No	0	6	4
36	R:R:E37	R:R:S281	5.75	Yes	No	10	7	6
37	R:R:E37	R:R:Y284	4.49	Yes	Yes	0	7	7
38	R:R:E37	R:R:M288	4.06	Yes	No	0	7	8
39	R:R:F38	R:R:L42	2.44	Yes	No	11	7	7
40	R:R:F38	R:R:I77	2.51	Yes	No	11	7	6
41	R:R:F38	R:R:L80	2.44	Yes	No	0	7	8
42	R:R:F38	R:R:P81	10.11	Yes	No	0	7	8
43	R:R:F40	R:R:I39	5.02	No	No	0	6	5
44	R:R:I77	R:R:L42	2.85	No	No	11	6	7
45	R:R:G44	R:R:L43	5.13	No	No	0	7	4
46	R:R:D73	R:R:N45	14.81	No	No	0	9	9
47	R:R:N45	R:R:P291	8.15	No	Yes	0	9	9
48	R:R:I51	R:R:L47	2.85	No	No	0	7	6
49	R:R:F296	R:R:L47	2.44	No	No	0	8	6
50	R:R:A48	R:R:Y295	2.67	No	Yes	0	9	7
51	R:R:F67	R:R:L49	3.65	No	No	0	6	7
52	R:R:F74	R:R:L49	3.65	No	No	0	7	7
53	R:R:F54	R:R:W50	8.02	No	No	0	4	4
54	R:R:H55	R:R:W50	6.35	No	No	0	5	4
55	R:R:F52	R:R:L56	3.65	Yes	Yes	2	7	5
56	R:R:F52	R:R:R63	4.28	Yes	No	2	7	7
57	R:R:F52	R:R:L66	2.44	Yes	No	2	7	8
58	R:R:F52	R:R:Y295	8.25	Yes	Yes	2	7	7
59	R:R:C53	R:R:F54	5.59	No	No	0	4	4
60	R:R:L56	R:R:W59	4.56	Yes	No	0	5	6
61	R:R:L56	R:R:R63	4.86	Yes	No	2	5	7
62	R:R:I139	R:R:S61	7.74	No	No	0	7	6
63	R:R:D124	R:R:S62	5.89	No	No	0	8	8
64	R:R:A144	R:R:I64	3.25	No	No	0	7	7
65	R:R:F65	R:R:V120	7.87	No	No	0	7	7
66	R:R:A144	R:R:F65	2.77	No	No	0	7	7
67	R:R:F65	R:R:S148	2.64	No	No	0	7	8
68	R:R:L66	R:R:V121	2.98	No	No	2	8	9
69	R:R:L66	R:R:Y295	3.52	No	Yes	2	8	7
70	R:R:F117	R:R:N68	13.29	Yes	Yes	12	8	9
71	R:R:N68	R:R:S148	8.94	Yes	No	0	9	8
72	R:R:N68	R:R:W152	5.65	Yes	No	12	9	9
73	R:R:L69	R:R:S114	3	Yes	No	0	9	9
74	R:R:F117	R:R:L69	2.44	Yes	Yes	0	8	9
75	R:R:D290	R:R:L69	10.86	Yes	Yes	0	9	9
76	R:R:L69	R:R:Y295	3.52	Yes	Yes	0	9	7
77	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
78	R:R:A72	R:R:W152	2.59	No	No	0	8	9
79	R:R:D73	R:R:S287	4.42	No	No	0	9	8
80	R:R:D290	R:R:D73	2.66	Yes	No	0	9	9
81	R:R:L75	R:R:N110	10.98	No	Yes	0	6	9
82	R:R:L107	R:R:L76	4.15	No	No	0	6	7
83	R:R:L76	R:R:N110	5.49	No	Yes	0	7	9
84	R:R:L76	R:R:Y284	4.69	No	Yes	0	7	7
85	R:R:C79	R:R:M103	3.24	No	Yes	0	6	5
86	R:R:C79	R:R:M106	3.24	No	No	0	6	5
87	R:R:C79	R:R:L107	4.76	No	No	0	6	6
88	R:R:F82	R:R:F95	4.29	No	No	0	6	7
89	R:R:L83	R:R:Y87	9.38	No	Yes	0	6	6
90	R:R:L83	R:R:M103	2.83	No	Yes	0	6	5
91	R:R:D85	R:R:F95	3.58	No	No	0	4	7
92	R:R:N86	R:R:W91	9.04	No	No	0	5	4
93	R:R:W91	R:R:Y87	9.65	No	Yes	9	4	6
94	R:R:F277	R:R:Y87	3.09	No	Yes	9	5	6
95	R:R:D92	R:R:R89	3.57	No	No	0	4	4
96	R:R:F277	R:R:W91	6.01	No	No	9	5	4
97	R:R:D92	R:R:K94	9.68	No	No	0	4	3
98	R:R:A174	R:R:D92	4.63	No	No	0	2	4
99	R:R:F95	R:R:W93	8.02	No	Yes	0	7	9
100	R:R:C100	R:R:W93	6.53	Yes	Yes	0	9	9
101	R:R:M103	R:R:W93	3.49	Yes	Yes	0	5	9
102	R:R:D97	R:R:R101	4.76	No	No	0	3	6
103	R:R:D97	R:R:K166	5.53	No	No	0	3	4
104	R:R:D97	R:R:P168	14.49	No	No	0	3	4
105	R:R:I98	R:R:P99	3.39	No	No	0	2	5
106	R:R:I98	R:R:R101	2.51	No	No	0	2	6
107	R:R:C100	R:R:M167	3.24	Yes	Yes	4	9	3
108	R:R:C100	R:R:P168	7.53	Yes	No	4	9	4
109	R:R:C100	R:R:C177	7.28	Yes	No	4	9	9
110	R:R:L104	R:R:M103	2.83	No	Yes	0	5	5
111	R:R:L104	R:R:M167	4.24	No	Yes	4	5	3
112	R:R:C177	R:R:L104	4.76	No	No	4	9	5
113	R:R:F105	R:R:M109	3.73	No	Yes	13	6	5
114	R:R:F105	R:R:T159	6.49	No	No	13	6	7
115	R:R:F105	R:R:L163	7.31	No	No	0	6	5
116	R:R:M106	R:R:N110	4.21	No	Yes	0	5	9
117	R:R:M109	R:R:N110	5.61	Yes	Yes	0	5	9
118	R:R:M109	R:R:T155	3.01	Yes	No	0	5	7
119	R:R:I156	R:R:M109	4.37	No	Yes	0	4	5
120	R:R:M109	R:R:T159	9.03	Yes	No	13	5	7
121	R:R:E196	R:R:R111	4.65	No	No	0	5	8
122	R:R:R111	R:R:T283	2.59	No	Yes	0	8	8
123	R:R:Q112	R:R:T155	4.25	No	No	0	7	7
124	R:R:L158	R:R:Q112	3.99	No	No	0	5	7
125	R:R:M192	R:R:Q112	10.88	No	No	0	5	7
126	R:R:G113	R:R:T155	3.64	No	No	0	7	7
127	R:R:E196	R:R:I115	5.47	No	No	0	5	8
128	R:R:I115	R:R:P200	3.39	No	No	0	8	9
129	R:R:F244	R:R:I115	7.54	Yes	No	0	8	8
130	R:R:I116	R:R:L151	5.71	No	Yes	0	5	7
131	R:R:F117	R:R:L151	7.31	Yes	Yes	0	8	7
132	R:R:F117	R:R:W152	9.02	Yes	No	12	8	9
133	R:R:F240	R:R:L118	2.44	Yes	No	0	9	9
134	R:R:L118	R:R:Y294	3.52	No	Yes	0	9	9
135	R:R:P200	R:R:T119	3.5	No	No	0	9	7
136	R:R:I203	R:R:T119	4.56	No	No	0	7	7
137	R:R:R125	R:R:V121	6.54	No	No	2	9	9
138	R:R:V121	R:R:Y294	3.79	No	Yes	2	9	9
139	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
140	R:R:D124	R:R:R128	4.76	No	No	0	8	8
141	R:R:R125	R:R:Y294	4.12	No	Yes	2	9	9
142	R:R:V130	R:R:Y126	13.88	Yes	Yes	3	8	7
143	R:R:H131	R:R:Y126	4.36	Yes	Yes	3	7	7
144	R:R:F206	R:R:Y126	4.13	No	Yes	3	4	7
145	R:R:C207	R:R:Y126	5.38	No	Yes	0	8	7
146	R:R:R210	R:R:Y126	8.23	Yes	Yes	3	4	7
147	R:R:F127	R:R:H131	3.39	Yes	Yes	3	5	7
148	R:R:F127	R:R:H134	3.39	Yes	No	3	5	4
149	R:R:F127	R:R:L136	3.65	Yes	No	3	5	4
150	R:R:N137	R:R:R128	9.64	No	No	0	4	8
151	R:R:I211	R:R:V129	6.14	No	No	0	8	8
152	R:R:H131	R:R:V130	5.54	Yes	Yes	3	7	8
153	R:R:R210	R:R:V130	2.62	Yes	Yes	3	4	8
154	R:R:S214	R:R:V130	4.85	No	Yes	0	5	8
155	R:R:H133	R:R:P132	6.1	No	No	0	6	8
156	R:R:H134	R:R:L136	2.57	No	No	3	4	4
157	R:R:H134	R:R:N137	5.1	No	No	0	4	4
158	R:R:S140	R:R:T143	3.2	No	No	0	6	3
159	R:R:I147	R:R:L151	2.85	No	Yes	0	5	7
160	R:R:H161	R:R:L162	7.71	No	No	0	7	4
161	R:R:M167	R:R:P168	3.35	Yes	No	4	3	4
162	R:R:I169	R:R:M167	2.92	No	Yes	0	1	3
163	R:R:C177	R:R:M167	4.86	No	Yes	4	9	3
164	R:R:I169	R:R:L176	2.85	No	Yes	0	1	4
165	R:R:N175	R:R:Q170	6.6	No	No	0	4	1
166	R:R:L176	R:R:N171	2.75	Yes	Yes	5	4	1
167	R:R:L176	R:R:S178	3	Yes	No	0	4	4
168	R:R:S178	R:R:S181	3.26	No	No	0	4	4
169	R:R:H189	R:R:S179	8.37	No	No	0	5	4
170	R:R:F180	R:R:H189	7.92	No	No	0	3	5
171	R:R:F180	R:R:F276	8.57	No	Yes	1	3	4
172	R:R:F180	R:R:L280	3.65	No	Yes	1	3	5
173	R:R:I182	R:R:I254	2.94	Yes	No	0	3	4
174	R:R:I182	R:R:L258	4.28	Yes	No	1	3	3
175	R:R:I182	R:R:Y269	6.04	Yes	No	1	3	2
176	R:R:D273	R:R:I182	5.6	No	Yes	0	4	3
177	R:R:H184	R:R:T263	4.11	No	No	0	3	3
178	R:R:H184	W:W:?1	8.43	No	Yes	0	3	0
179	R:R:Q187	R:R:T185	4.25	No	No	0	2	2
180	R:R:F186	W:W:?1	7.98	No	Yes	0	4	0
181	R:R:E190	R:R:Q187	2.55	No	No	0	4	2
182	R:R:E190	R:R:R251	8.14	No	Yes	0	4	5
183	R:R:E190	W:W:?1	13.51	No	Yes	0	4	0
184	R:R:A191	W:W:?1	6.88	No	Yes	0	3	0
185	R:R:E196	R:R:F193	7	No	Yes	0	5	6
186	R:R:F193	R:R:R251	3.21	Yes	Yes	1	6	5
187	R:R:F193	R:R:F276	4.29	Yes	Yes	1	6	4
188	R:R:F193	R:R:L280	2.44	Yes	Yes	1	6	5
189	R:R:F255	R:R:L194	2.44	No	Yes	1	5	4
190	R:R:L194	W:W:?1	5.04	Yes	Yes	1	4	0
191	R:R:L195	R:R:L199	2.77	No	No	0	4	4
192	R:R:L195	W:W:?1	4.03	No	Yes	0	4	0
193	R:R:F197	R:R:F198	7.5	Yes	No	0	8	5
194	R:R:F197	R:R:L201	4.87	Yes	Yes	6	8	7
195	R:R:F197	R:R:F240	4.29	Yes	Yes	6	8	9
196	R:R:F197	R:R:F244	4.29	Yes	Yes	6	8	8
197	R:R:F197	R:R:L245	7.31	Yes	No	0	8	6
198	R:R:F198	W:W:?1	3.55	No	Yes	0	5	0
199	R:R:F240	R:R:P200	2.89	Yes	No	0	9	9
200	R:R:L201	R:R:L205	2.77	Yes	No	0	7	4
201	R:R:F240	R:R:L201	2.44	Yes	Yes	6	9	7
202	R:R:F206	R:R:R210	7.48	No	Yes	3	4	4
203	R:R:I233	R:R:S208	3.1	No	No	0	7	8
204	R:R:R210	R:R:W213	7	Yes	No	0	4	3
205	R:R:I211	R:R:I233	2.94	No	No	0	8	7
206	R:R:I212	R:R:R216	2.51	Yes	No	7	5	4
207	R:R:I212	R:R:I230	7.36	Yes	No	7	5	6
208	R:R:I212	R:R:M234	2.92	Yes	No	0	5	4
209	R:R:Q217	R:R:W213	15.33	No	No	0	5	3
210	R:R:Q217	R:R:S214	2.89	No	No	0	5	5
211	R:R:I226	R:R:L215	7.14	Yes	No	0	6	8
212	R:R:D221	R:R:R216	10.72	No	No	7	3	4
213	R:R:I230	R:R:R216	2.51	No	No	7	6	4
214	R:R:M220	R:R:R218	7.44	No	No	0	3	5
215	R:R:D221	R:R:K227	4.15	No	No	0	3	4
216	R:R:D221	R:R:I230	4.2	No	No	7	3	6
217	R:R:H223	R:R:K225	5.24	No	No	0	4	5
218	R:R:F232	R:R:R228	7.48	Yes	No	0	7	7
219	R:R:F232	R:R:T231	6.49	Yes	No	0	7	6
220	R:R:F232	R:R:V235	5.24	Yes	No	0	7	5
221	R:R:F232	R:R:S298	3.96	Yes	No	0	7	8
222	R:R:V236	R:R:Y294	7.57	No	Yes	0	8	9
223	R:R:L289	R:R:V239	5.96	No	No	0	7	7
224	R:R:F240	R:R:F244	4.29	Yes	Yes	6	9	8
225	R:R:I242	R:R:V241	3.07	No	No	0	5	5
226	R:R:C243	R:R:M285	3.24	No	No	0	8	5
227	R:R:C243	R:R:N286	9.45	No	No	0	8	9
228	R:R:F244	R:R:T283	3.89	Yes	Yes	0	8	8
229	R:R:F244	R:R:N286	8.46	Yes	No	0	8	9
230	R:R:L245	R:R:P246	3.28	No	No	0	6	9
231	R:R:F282	R:R:P246	5.78	No	No	0	7	9
232	R:R:S247	R:R:T279	3.2	No	No	0	6	7
233	R:R:T279	R:R:V250	3.17	No	No	0	7	5
234	R:R:I254	R:R:R251	2.51	No	Yes	0	4	5
235	R:R:F255	R:R:R251	5.34	No	Yes	1	5	5
236	R:R:F276	R:R:R251	13.9	Yes	Yes	1	4	5
237	R:R:L257	R:R:R253	7.29	No	No	0	3	5
238	R:R:I254	R:R:V272	3.07	No	Yes	0	4	4
239	R:R:F255	W:W:?1	15.96	No	Yes	1	5	0
240	R:R:T260	R:R:W256	7.28	No	No	0	1	4
241	R:R:L257	R:R:V272	4.47	No	Yes	0	3	4
242	R:R:L258	R:R:Y269	7.03	No	No	1	3	2
243	R:R:L258	W:W:?1	8.06	No	Yes	1	3	0
244	R:R:S261	R:R:T260	3.2	No	No	0	3	1
245	R:R:E267	R:R:N265	13.15	No	No	0	2	5
246	R:R:V272	R:R:Y269	2.52	Yes	No	0	4	2
247	R:R:S271	R:R:V272	3.23	No	Yes	0	3	4
248	R:R:D273	R:R:F277	7.17	No	No	0	4	5
249	R:R:I278	R:R:L274	2.85	No	No	0	6	1
250	R:R:F276	R:R:T279	2.59	Yes	No	0	4	7
251	R:R:F276	R:R:L280	6.09	Yes	Yes	1	4	5
252	R:R:L280	R:R:T283	4.42	Yes	Yes	0	5	8
253	R:R:T283	R:R:Y284	3.75	Yes	Yes	0	8	7
254	R:R:M285	R:R:M288	4.33	No	No	0	5	8
255	R:R:L289	R:R:M285	2.83	No	No	0	7	5
256	R:R:D290	R:R:P291	3.22	Yes	Yes	0	9	9
257	R:R:D290	R:R:Y294	5.75	Yes	Yes	0	9	9
258	R:R:P291	R:R:Y295	2.78	Yes	Yes	0	9	7
259	R:R:F74	R:R:N45	2.42	No	No	0	7	9
260	R:R:N171	R:R:R22	2.41	Yes	No	0	1	3
261	R:R:L80	R:R:Y284	2.34	No	Yes	0	8	7
262	R:R:G172	R:R:G173	2.11	No	No	0	3	4
263	R:R:G44	R:R:P291	2.03	No	Yes	0	7	9
264	R:R:G262	R:R:S261	1.86	No	No	0	4	3
265	R:R:G41	R:R:I77	1.76	No	No	0	8	6
266	R:R:G35	R:R:M84	1.75	No	No	0	5	7
267	R:R:C183	R:R:S181	1.72	No	No	0	1	4
268	R:R:G46	R:R:L49	1.71	No	No	0	4	7
269	R:R:A144	R:R:S61	1.71	No	No	0	7	6
270	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
271	R:R:A108	R:R:T159	1.68	No	No	0	4	7
272	R:R:L30	R:R:P31	1.64	Yes	No	0	5	6
273	R:R:C207	R:R:I203	1.64	No	No	0	8	7
274	R:R:A122	R:R:I204	1.62	No	No	0	9	8
275	R:R:A237	R:R:I204	1.62	No	No	0	7	8
276	R:R:A229	R:R:I226	1.62	No	Yes	0	7	6
277	R:R:V129	R:R:V130	1.6	No	Yes	0	8	8
278	R:R:V235	R:R:V236	1.6	No	No	0	5	8
279	R:R:V236	R:R:V293	1.6	No	No	0	8	8
280	R:R:V249	R:R:V250	1.6	No	No	0	6	5
281	R:R:V292	R:R:V293	1.6	No	No	0	6	8
282	R:R:C266	R:R:L11	1.59	No	No	0	7	8
283	R:R:A108	R:R:L162	1.58	No	No	0	4	4
284	R:R:A237	R:R:L205	1.58	No	No	0	7	4
285	R:R:I156	R:R:V160	1.54	No	No	0	4	4
286	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
287	R:R:K28	R:R:V27	1.52	No	No	0	3	3
288	R:R:M84	R:R:V88	1.52	No	No	0	7	3
289	R:R:F40	R:R:G41	1.51	No	No	0	6	8
290	R:R:L56	R:R:S58	1.5	Yes	No	0	5	6
291	R:R:L215	R:R:V129	1.49	No	No	0	8	8
292	R:R:L194	R:R:V248	1.49	Yes	No	0	4	8
293	R:R:L201	R:R:V241	1.49	Yes	No	0	7	5
294	R:R:L257	R:R:V268	1.49	No	No	0	3	1
295	R:R:N68	R:R:V71	1.48	Yes	No	0	9	6
296	R:R:I212	R:R:I233	1.47	Yes	No	0	5	7
297	R:R:I238	R:R:I242	1.47	No	No	0	5	5
298	R:R:I226	R:R:M220	1.46	Yes	No	0	6	3
299	R:R:K15	R:R:K16	1.44	No	No	0	3	4
300	R:R:I13	R:R:L11	1.43	No	No	0	3	8
301	R:R:I98	R:R:L102	1.43	No	No	0	2	5
302	R:R:I146	R:R:L150	1.43	No	No	0	3	4
303	R:R:I154	R:R:L151	1.43	No	Yes	0	5	7
304	R:R:I154	R:R:L158	1.43	No	No	0	5	5
305	R:R:I252	R:R:L194	1.43	No	Yes	0	6	4
306	R:R:E267	R:R:V268	1.43	No	No	0	2	1
307	R:R:I64	R:R:N141	1.42	No	No	0	7	2
308	R:R:A145	R:R:R142	1.38	No	No	0	3	4
309	R:R:H223	R:R:I226	1.33	No	Yes	0	4	6
310	R:R:F232	R:R:S297	1.32	Yes	No	0	7	6
311	R:R:F296	R:R:V292	1.31	No	No	0	8	6
312	R:R:A191	R:R:W188	1.3	No	No	0	3	5
313	R:R:F74	R:R:I78	1.26	No	No	0	7	6
314	R:R:N175	R:R:W93	1.13	No	Yes	0	4	9
315	R:R:H259	R:R:W256	1.06	No	No	0	1	4
316	R:R:R253	R:R:W256	1	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:E12	5.295	4	5	5
2	R:R:F21	6.804	5	8	2
3	R:R:L30	2.9375	4	0	5
4	R:R:E37	4.2875	4	10	7
5	R:R:F38	4.375	4	11	7
6	R:R:F52	4.655	4	2	7
7	R:R:L56	3.6425	4	2	5
8	R:R:N68	7.34	4	12	9
9	R:R:L69	4.955	4	0	9
10	R:R:Y87	7.04	4	9	6
11	R:R:W93	4.7925	4	0	9
12	R:R:C100	6.145	4	4	9
13	R:R:M103	3.0975	4	0	5
14	R:R:M109	5.15	5	13	5
15	R:R:N110	6.5725	4	0	9
16	R:R:F117	8.015	4	12	8
17	R:R:Y126	7.196	5	3	7
18	R:R:F127	3.2625	4	3	5
19	R:R:V130	5.698	5	3	8
20	R:R:H131	3.705	4	3	7
21	R:R:L151	4.325	4	0	7
22	R:R:M167	3.722	5	4	3
23	R:R:N171	3.345	4	5	1
24	R:R:L176	3.41	5	5	4
25	R:R:I182	4.715	4	1	3
26	R:R:F193	4.235	4	1	6
27	R:R:L194	2.6	4	1	4
28	R:R:F197	5.652	5	6	8
29	R:R:L201	2.656	5	6	7
30	R:R:R210	6.3325	4	3	4
31	R:R:I212	3.565	4	7	5
32	R:R:I226	2.8875	4	0	6
33	R:R:F232	4.898	5	0	7
34	R:R:F240	3.27	5	6	9
35	R:R:F244	5.694	5	6	8
36	R:R:R251	6.62	5	1	5
37	R:R:V272	3.3225	4	0	4
38	R:R:F276	7.088	5	1	4
39	R:R:L280	4.15	4	1	5
40	R:R:T283	3.6625	4	0	8
41	R:R:Y284	3.8175	4	0	7
42	R:R:D290	5.6225	4	0	9
43	R:R:P291	4.045	4	0	9
44	R:R:Y294	4.95	5	2	9
45	R:R:Y295	4.12333	6	2	7
46	W:W:?1	8.16	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I169	R:R:M167	34.2044	2.92	No	Yes	0	1	3
2	R:R:L104	R:R:M167	48.8326	4.24	No	Yes	4	5	3
3	R:R:L104	R:R:M103	52.6226	2.83	No	Yes	0	5	5
4	R:R:L83	R:R:M103	32.8504	2.83	No	Yes	0	6	5
5	R:R:L83	R:R:Y87	31.819	9.38	No	Yes	0	6	6
6	R:R:F277	R:R:Y87	44.2898	3.09	No	Yes	9	5	6
7	R:R:D273	R:R:F277	48.0164	7.17	No	No	0	4	5
8	R:R:D273	R:R:F21	20.1329	5.97	No	Yes	0	4	2
9	R:R:I169	R:R:L176	27.8456	2.85	No	Yes	0	1	4
10	R:R:L176	R:R:N171	13.1667	2.75	Yes	Yes	5	4	1
11	R:R:D273	R:R:I182	59.8861	5.6	No	Yes	0	4	3
12	R:R:I182	R:R:I254	24.1949	2.94	Yes	No	0	3	4
13	R:R:I254	R:R:R251	34.236	2.51	No	Yes	0	4	5
14	R:R:E190	R:R:Q187	13.4198	2.55	No	No	0	4	2
15	R:R:Q187	R:R:T185	10.8067	4.25	No	No	0	2	2
16	R:R:I182	R:R:L258	32.5973	4.28	Yes	No	1	3	3
17	R:R:L258	W:W:?1	42.1449	8.06	No	Yes	1	3	0
18	R:R:N171	R:R:R22	11.0978	2.41	Yes	No	0	1	3
19	R:R:F25	R:R:L274	10.7877	12.18	No	No	0	6	1
20	R:R:I26	R:R:L274	15.0016	2.85	No	No	0	5	1
21	R:R:I26	R:R:Y87	34.1664	6.04	No	Yes	0	5	6
22	R:R:I26	R:R:L30	17.1908	4.28	No	Yes	0	5	5
23	R:R:L30	R:R:P31	11.0345	1.64	Yes	No	0	5	6
24	R:R:E37	R:R:Y284	12.515	4.49	Yes	Yes	0	7	7
25	R:R:T283	R:R:Y284	100	3.75	Yes	Yes	0	8	7
26	R:R:L280	R:R:T283	30.7687	4.42	Yes	Yes	0	5	8
27	R:R:F193	R:R:L280	11.4837	2.44	Yes	Yes	1	6	5
28	R:R:F193	R:R:R251	26.789	3.21	Yes	Yes	1	6	5
29	R:R:F276	R:R:L280	14.9257	6.09	Yes	Yes	1	4	5
30	R:R:F276	R:R:R251	13.1414	13.9	Yes	Yes	1	4	5
31	R:R:L80	R:R:Y284	23.4673	2.34	No	Yes	0	8	7
32	R:R:F38	R:R:L80	18.8738	2.44	Yes	No	0	7	8
33	R:R:F38	R:R:I77	11.857	2.51	Yes	No	11	7	6
34	R:R:F198	W:W:?1	52.4518	3.55	No	Yes	0	5	0
35	R:R:F197	R:R:F198	53.1288	7.5	Yes	No	0	8	5
36	R:R:F197	R:R:F240	44.448	4.29	Yes	Yes	6	8	9
37	R:R:F240	R:R:L118	87.9658	2.44	Yes	No	0	9	9
38	R:R:L118	R:R:Y294	86.9219	3.52	No	Yes	0	9	9
39	R:R:D290	R:R:Y294	57.2287	5.75	Yes	Yes	0	9	9
40	R:R:D290	R:R:P291	19.9177	3.22	Yes	Yes	0	9	9
41	R:R:D290	R:R:D73	13.8627	2.66	Yes	No	0	9	9
42	R:R:D73	R:R:N45	10.3828	14.81	No	No	0	9	9
43	R:R:N45	R:R:P291	12.0468	8.15	No	Yes	0	9	9
44	R:R:V236	R:R:Y294	22.031	7.57	No	Yes	0	8	9
45	R:R:L66	R:R:V121	13.4767	2.98	No	No	2	8	9
46	R:R:V121	R:R:Y294	14.9699	3.79	No	Yes	2	9	9
47	R:R:D290	R:R:L69	29.9905	10.86	Yes	Yes	0	9	9
48	R:R:F74	R:R:N45	18.4309	2.42	No	No	0	7	9
49	R:R:F74	R:R:L49	10.9839	3.65	No	No	0	7	7
50	R:R:F117	R:R:L69	27.814	2.44	Yes	Yes	0	8	9
51	R:R:F117	R:R:N68	18.7852	13.29	Yes	Yes	12	8	9
52	R:R:N68	R:R:S148	15.2294	8.94	Yes	No	0	9	8
53	R:R:F65	R:R:S148	13.3692	2.64	No	No	0	7	8
54	R:R:H134	R:R:N137	10.3322	5.1	No	No	0	4	4
55	R:R:F127	R:R:H134	12.9136	3.39	Yes	No	3	5	4
56	R:R:F127	R:R:H131	20.7086	3.39	Yes	Yes	3	5	7
57	R:R:H131	R:R:Y126	26.7257	4.36	Yes	Yes	3	7	7
58	R:R:C207	R:R:Y126	90.9459	5.38	No	Yes	0	8	7
59	R:R:C207	R:R:I203	93.1224	1.64	No	No	0	8	7
60	R:R:I203	R:R:T119	95.2863	4.56	No	No	0	7	7
61	R:R:P200	R:R:T119	97.4375	3.5	No	No	0	9	7
62	R:R:I115	R:R:P200	43.1825	3.39	No	No	0	8	9
63	R:R:E196	R:R:I115	22.2967	5.47	No	No	0	5	8
64	R:R:E196	R:R:F193	21.7273	7	No	Yes	0	5	6
65	R:R:F240	R:R:P200	60.9934	2.89	Yes	No	0	9	9
66	R:R:C79	R:R:M103	71.9772	3.24	No	Yes	0	6	5
67	R:R:C79	R:R:M106	16.3239	3.24	No	No	0	6	5
68	R:R:M106	R:R:N110	17.4945	4.21	No	Yes	0	5	9
69	R:R:C79	R:R:L107	56.6593	4.76	No	No	0	6	6
70	R:R:L107	R:R:L76	58.0006	4.15	No	No	0	6	7
71	R:R:M103	R:R:W93	28.5606	3.49	Yes	Yes	0	5	9
72	R:R:C100	R:R:W93	17.3806	6.53	Yes	Yes	0	9	9
73	R:R:D97	R:R:P168	25.6564	14.49	No	No	0	3	4
74	R:R:C100	R:R:P168	14.6979	7.53	Yes	No	4	9	4
75	R:R:M167	R:R:P168	15.1851	3.35	Yes	No	4	3	4
76	R:R:D97	R:R:R101	17.1528	4.76	No	No	0	3	6
77	R:R:I98	R:R:R101	12.882	2.51	No	No	0	2	6
78	R:R:M109	R:R:N110	35.5204	5.61	Yes	Yes	0	5	9
79	R:R:M109	R:R:T155	21.4552	3.01	Yes	No	0	5	7
80	R:R:Q112	R:R:T155	18.5827	4.25	No	No	0	7	7
81	R:R:L158	R:R:Q112	15.6849	3.99	No	No	0	5	7
82	R:R:F197	R:R:F244	13.8374	4.29	Yes	Yes	6	8	8
83	R:R:F117	R:R:L151	17.4502	7.31	Yes	Yes	0	8	7
84	R:R:V130	R:R:Y126	52.6099	13.88	Yes	Yes	3	8	7
85	R:R:V129	R:R:V130	47.5166	1.6	No	Yes	0	8	8
86	R:R:I211	R:R:V129	28.143	6.14	No	No	0	8	8
87	R:R:I211	R:R:I233	25.6058	2.94	No	No	0	8	7
88	R:R:I212	R:R:I233	20.696	1.47	Yes	No	0	5	7
89	R:R:L215	R:R:V129	17.8931	1.49	No	No	0	8	8
90	R:R:I226	R:R:L215	15.5267	7.14	Yes	No	0	6	8
91	R:R:V235	R:R:V236	11.2559	1.6	No	No	0	5	8
92	R:R:F244	R:R:N286	11.3508	8.46	Yes	No	0	8	9
93	R:R:I254	R:R:V272	18.6587	3.07	No	Yes	0	4	4
94	R:R:L257	R:R:V272	26.441	4.47	No	Yes	0	3	4
95	R:R:V272	R:R:Y269	13.9513	2.52	Yes	No	0	4	2
96	R:R:L257	R:R:R253	16.0139	7.29	No	No	0	3	5
97	R:R:R253	R:R:W256	13.3755	1	No	No	0	5	4
98	R:R:I154	R:R:L158	15.3116	1.43	No	No	0	5	5
99	R:R:L76	R:R:Y284	83.3154	4.69	No	Yes	0	7	7
100	R:R:F244	R:R:T283	91.6482	3.89	Yes	Yes	0	8	8
101	R:R:F240	R:R:F244	63.3534	4.29	Yes	Yes	6	9	8
102	R:R:I154	R:R:L151	15.4192	1.43	No	Yes	0	5	7
103	R:R:F244	R:R:I115	26.9788	7.54	Yes	No	0	8	8
104	R:R:F240	R:R:L201	12.1227	2.44	Yes	Yes	6	9	7
105	R:R:L76	R:R:N110	24.7517	5.49	No	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I182	R:R:L258	4.28	1	Yes	No	3	3	2	1
R:R:I182	R:R:Y269	6.04	1	Yes	No	3	2	2	2
R:R:H184	R:R:T263	4.11	0	No	No	3	3	1	2
R:R:H184	W:W:?1	8.43	0	No	Yes	3	0	1	0
R:R:F186	W:W:?1	7.98	0	No	Yes	4	0	1	0
R:R:E190	R:R:Q187	2.55	0	No	No	4	2	1	2
R:R:E190	R:R:R251	8.14	0	No	Yes	4	5	1	2
R:R:E190	W:W:?1	13.51	0	No	Yes	4	0	1	0
R:R:A191	W:W:?1	6.88	0	No	Yes	3	0	1	0
R:R:F255	R:R:L194	2.44	1	No	Yes	5	4	1	1
R:R:L194	W:W:?1	5.04	1	Yes	Yes	4	0	1	0
R:R:L195	R:R:L199	2.77	0	No	No	4	4	1	2
R:R:L195	W:W:?1	4.03	0	No	Yes	4	0	1	0
R:R:F197	R:R:F198	7.5	6	Yes	No	8	5	2	1
R:R:F198	W:W:?1	3.55	0	No	Yes	5	0	1	0
R:R:F255	R:R:R251	5.34	1	No	Yes	5	5	1	2
R:R:F255	W:W:?1	15.96	1	No	Yes	5	0	1	0
R:R:L258	R:R:Y269	7.03	1	No	No	3	2	1	2
R:R:L258	W:W:?1	8.06	1	No	Yes	3	0	1	0
R:R:L194	R:R:V248	1.49	1	Yes	No	4	8	1	2
R:R:I252	R:R:L194	1.43	0	No	Yes	6	4	2	1
R:R:A191	R:R:W188	1.3	0	No	No	3	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JHY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	275
Number of Links	316
Number of Hubs	46
Number of Links mediated by Hubs	167
Number of Communities	13
Number of Nodes involved in Communities	62
Number of Links involved in Communities	77

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	51507
Length Of Smallest Path	3
Average Path Length	13.4542
Length of Longest Path	30
Minimum Path Strength	1.03
Average Path Strength	4.64233
Maximum Path Strength	17.015
Minimum Path Correlation	0.7
Average Path Correlation	0.920847
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	48.8136
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.5525
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • inflammatory cell apoptotic process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • positive regulation of cell communication • system process • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • adiponectin secretion • endocrine hormone secretion • positive regulation of multicellular organismal process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • regulation of multicellular organismal process • positive regulation of protein secretion • endocrine process • positive regulation of transport • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • negative regulation of metabolic process • regulation of catabolic process • regulation of lipid catabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	IX8
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	IX8
Name	7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide
Synonyms
Identifier
Formula	C26 H28 N4 O2
Molecular Weight	428.526
SMILES
PubChem	25101223
Formal Charge	0
Total Atoms	60
Total Chiral Atoms	1
Total Bonds	63
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8JHY_nogp_Chain_R F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	To be published
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	To be published
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	To be published
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	To be published

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