psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D8	R:R:F10	9.55	No	No	0	6	7
2	R:R:F21	R:R:H9	10.18	Yes	No	0	2	6
3	R:R:F10	R:R:N17	6.04	No	No	0	7	5
4	R:R:C266	R:R:F10	5.59	No	No	0	7	7
5	R:R:I169	R:R:L11	2.85	No	No	0	1	8
6	R:R:L11	R:R:N171	5.49	No	No	0	8	1
7	R:R:C18	R:R:I13	4.91	No	No	4	9	3
8	R:R:I13	R:R:I169	2.94	No	No	0	3	1
9	R:R:C183	R:R:I13	3.27	Yes	No	4	1	3
10	R:R:D14	R:R:K165	6.91	No	No	0	5	4
11	R:R:C18	R:R:S181	3.44	No	No	4	9	4
12	R:R:C18	R:R:C183	7.28	No	Yes	4	9	1
13	R:R:C19	R:R:F21	4.19	No	Yes	0	4	2
14	R:R:C19	R:R:C266	7.28	No	No	0	4	7
15	R:R:C19	R:R:Y269	4.03	No	Yes	0	4	2
16	R:R:F21	R:R:R270	7.48	Yes	No	0	2	1
17	R:R:D273	R:R:F21	5.97	No	Yes	0	4	2
18	R:R:R22	R:R:R90	9.6	No	No	0	3	4
19	R:R:R22	R:R:W91	10	No	Yes	0	3	4
20	R:R:D23	R:R:R270	4.76	No	No	0	4	1
21	R:R:D23	R:R:L274	8.14	No	No	0	4	1
22	R:R:D24	R:R:F25	5.97	No	No	0	4	6
23	R:R:D24	R:R:R90	3.57	No	No	0	4	4
24	R:R:F25	R:R:V29	5.24	No	No	0	6	5
25	R:R:I26	R:R:L30	7.14	No	Yes	0	5	5
26	R:R:I26	R:R:W91	4.7	No	Yes	0	5	4
27	R:R:K28	R:R:V27	3.04	No	No	0	3	3
28	R:R:R90	R:R:V27	5.23	No	No	0	4	3
29	R:R:L30	R:R:V29	2.98	Yes	No	0	5	5
30	R:R:L30	R:R:Y87	4.69	Yes	No	0	5	6
31	R:R:I278	R:R:L30	2.85	Yes	Yes	6	6	5
32	R:R:L30	R:R:S281	3	Yes	No	6	5	6
33	R:R:P31	R:R:P32	5.84	No	No	0	6	5
34	R:R:P31	R:R:V88	3.53	No	No	0	6	3
35	R:R:E37	R:R:V33	4.28	Yes	No	0	7	5
36	R:R:L34	R:R:L80	4.15	No	No	0	8	8
37	R:R:L34	R:R:M84	4.24	No	No	0	8	7
38	R:R:E37	R:R:Y284	5.61	Yes	No	0	7	7
39	R:R:E37	R:R:M285	4.06	Yes	No	5	7	5
40	R:R:E37	R:R:M288	4.06	Yes	Yes	5	7	8
41	R:R:F38	R:R:L42	8.53	No	No	0	7	7
42	R:R:F38	R:R:M84	6.22	No	No	0	7	7
43	R:R:F40	R:R:M288	4.98	No	Yes	0	6	8
44	R:R:L49	R:R:N45	5.49	No	Yes	0	7	9
45	R:R:F74	R:R:N45	7.25	No	Yes	0	7	9
46	R:R:I51	R:R:L47	8.56	No	No	0	7	6
47	R:R:F67	R:R:L49	3.65	No	No	0	6	7
48	R:R:F52	R:R:L56	7.31	No	No	0	7	5
49	R:R:F52	R:R:R63	8.55	No	No	0	7	7
50	R:R:F52	R:R:Y295	10.32	No	Yes	0	7	7
51	R:R:K57	R:R:S58	3.06	No	No	0	5	6
52	R:R:F67	R:R:W59	10.02	No	No	0	6	6
53	R:R:F65	R:R:S61	5.28	No	No	0	7	6
54	R:R:I139	R:R:S61	3.1	No	No	0	7	6
55	R:R:A144	R:R:S61	3.42	No	No	0	7	6
56	R:R:D124	R:R:S62	4.42	No	No	0	8	8
57	R:R:L66	R:R:R63	3.64	No	No	0	8	7
58	R:R:A144	R:R:I64	3.25	No	No	0	7	7
59	R:R:F65	R:R:V120	7.87	No	No	0	7	7
60	R:R:L66	R:R:Y294	3.52	No	Yes	2	8	9
61	R:R:L66	R:R:Y295	8.21	No	Yes	2	8	7
62	R:R:F117	R:R:N68	14.5	No	No	7	8	9
63	R:R:N68	R:R:S148	8.94	No	No	0	9	8
64	R:R:N68	R:R:W152	5.65	No	Yes	7	9	9
65	R:R:D290	R:R:L69	4.07	No	No	0	9	9
66	R:R:L69	R:R:Y295	3.52	No	Yes	0	9	7
67	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
68	R:R:D73	R:R:S287	5.89	No	No	0	9	8
69	R:R:D290	R:R:D73	3.99	No	No	0	9	9
70	R:R:D73	R:R:P291	6.44	No	No	0	9	9
71	R:R:F74	R:R:I77	6.28	No	No	0	7	6
72	R:R:F74	R:R:I78	7.54	No	No	0	7	6
73	R:R:L76	R:R:L80	5.54	Yes	No	0	7	8
74	R:R:L76	R:R:N110	12.36	Yes	No	0	7	9
75	R:R:L76	R:R:Y284	8.21	Yes	No	0	7	7
76	R:R:L76	R:R:S287	6.01	Yes	No	0	7	8
77	R:R:C79	R:R:M103	3.24	No	No	0	6	5
78	R:R:C79	R:R:M106	3.24	No	No	0	6	5
79	R:R:C79	R:R:L107	4.76	No	No	0	6	6
80	R:R:L80	R:R:L83	4.15	No	No	0	8	6
81	R:R:F82	R:R:W93	8.02	No	Yes	0	6	9
82	R:R:L83	R:R:Y87	5.86	No	No	0	6	6
83	R:R:L107	R:R:L83	4.15	No	No	0	6	6
84	R:R:D85	R:R:R89	7.15	No	No	8	4	4
85	R:R:D85	R:R:F95	9.55	No	Yes	8	4	7
86	R:R:N86	R:R:W91	5.65	No	Yes	0	5	4
87	R:R:N86	R:R:W93	7.91	No	Yes	0	5	9
88	R:R:D92	R:R:R89	3.57	No	No	0	4	4
89	R:R:F95	R:R:R89	9.62	Yes	No	8	7	4
90	R:R:F277	R:R:W91	15.03	No	Yes	0	5	4
91	R:R:A174	R:R:D92	4.63	No	No	0	2	4
92	R:R:D92	R:R:N175	4.04	No	No	0	4	4
93	R:R:F95	R:R:W93	7.02	Yes	Yes	0	7	9
94	R:R:C100	R:R:W93	7.84	No	Yes	0	9	9
95	R:R:M103	R:R:W93	3.49	No	Yes	0	5	9
96	R:R:N175	R:R:W93	3.39	No	Yes	0	4	9
97	R:R:G96	R:R:P99	6.09	No	No	0	7	5
98	R:R:D97	R:R:I98	11.2	No	No	0	3	2
99	R:R:D97	R:R:K166	6.91	No	No	0	3	4
100	R:R:I98	R:R:P99	3.39	No	No	0	2	5
101	R:R:I98	R:R:R101	8.77	No	No	0	2	6
102	R:R:C100	R:R:P168	3.77	No	No	9	9	4
103	R:R:C100	R:R:C177	7.28	No	No	9	9	9
104	R:R:L163	R:R:R101	12.15	No	No	0	5	6
105	R:R:L104	R:R:L162	8.3	Yes	No	10	5	4
106	R:R:L104	R:R:M167	4.24	Yes	No	0	5	3
107	R:R:L104	R:R:S179	6.01	Yes	No	10	5	4
108	R:R:F105	R:R:M109	6.22	No	Yes	0	6	5
109	R:R:F105	R:R:T159	5.19	No	No	0	6	7
110	R:R:F105	R:R:L163	7.31	No	No	0	6	5
111	R:R:A108	R:R:T159	3.36	No	No	0	4	7
112	R:R:M109	R:R:W152	6.98	Yes	Yes	0	5	9
113	R:R:I156	R:R:M109	2.92	No	Yes	0	4	5
114	R:R:F193	R:R:R111	12.83	No	No	0	6	8
115	R:R:E196	R:R:R111	10.47	No	No	0	5	8
116	R:R:F244	R:R:R111	7.48	Yes	No	0	8	8
117	R:R:L158	R:R:Q112	3.99	No	No	0	5	7
118	R:R:E196	R:R:Q112	14.02	No	No	0	5	7
119	R:R:I115	R:R:P200	3.39	No	No	0	8	9
120	R:R:F244	R:R:I115	5.02	Yes	No	0	8	8
121	R:R:I116	R:R:L151	5.71	No	No	0	5	7
122	R:R:F117	R:R:L151	6.09	No	No	0	8	7
123	R:R:F117	R:R:W152	8.02	No	Yes	7	8	9
124	R:R:L118	R:R:Y294	4.69	No	Yes	0	9	9
125	R:R:P200	R:R:T119	3.5	No	No	0	9	7
126	R:R:I203	R:R:T119	4.56	No	No	0	7	7
127	R:R:R125	R:R:V121	5.23	No	No	2	9	9
128	R:R:V121	R:R:Y294	3.79	No	Yes	2	9	9
129	R:R:D124	R:R:R128	7.15	No	No	0	8	8
130	R:R:R125	R:R:Y294	10.29	No	Yes	2	9	9
131	R:R:F127	R:R:Y126	3.09	Yes	Yes	1	5	7
132	R:R:V130	R:R:Y126	12.62	Yes	Yes	1	8	7
133	R:R:H131	R:R:Y126	3.27	Yes	Yes	1	7	7
134	R:R:C207	R:R:Y126	6.72	No	Yes	0	8	7
135	R:R:R210	R:R:Y126	4.12	Yes	Yes	1	4	7
136	R:R:F127	R:R:H131	4.53	Yes	Yes	1	5	7
137	R:R:F127	R:R:H134	5.66	Yes	Yes	1	5	4
138	R:R:F127	R:R:L136	4.87	Yes	No	1	5	4
139	R:R:N137	R:R:R128	6.03	No	No	0	4	8
140	R:R:I211	R:R:V129	9.22	No	No	0	8	8
141	R:R:L215	R:R:V129	2.98	Yes	No	0	8	8
142	R:R:H131	R:R:V130	8.3	Yes	Yes	1	7	8
143	R:R:R210	R:R:V130	3.92	Yes	Yes	1	4	8
144	R:R:H131	R:R:H134	5.97	Yes	Yes	1	7	4
145	R:R:H133	R:R:P132	4.58	No	No	0	6	8
146	R:R:H134	R:R:L136	6.43	Yes	No	1	4	4
147	R:R:I139	R:R:T143	4.56	No	No	0	7	3
148	R:R:S140	R:R:T143	6.4	No	No	0	6	3
149	R:R:I147	R:R:L151	2.85	No	No	0	5	7
150	R:R:H161	R:R:K164	14.41	No	No	0	7	4
151	R:R:H161	R:R:H189	20.3	No	No	0	7	5
152	R:R:L162	R:R:S179	3	No	No	10	4	4
153	R:R:N175	R:R:P168	6.52	No	No	0	4	4
154	R:R:C177	R:R:P168	3.77	No	No	9	9	4
155	R:R:L176	R:R:N171	4.12	No	No	0	4	1
156	R:R:L176	R:R:S178	4.5	No	No	0	4	4
157	R:R:F180	R:R:R251	3.21	No	Yes	3	3	5
158	R:R:F180	R:R:F276	4.29	No	No	3	3	4
159	R:R:C183	R:R:S181	3.44	Yes	No	4	1	4
160	R:R:I182	R:R:Y269	7.25	No	Yes	0	3	2
161	R:R:D273	R:R:I182	7	No	No	0	4	3
162	R:R:C183	R:R:T185	3.38	Yes	No	0	1	2
163	R:R:H184	R:R:L258	12.86	No	No	12	3	3
164	R:R:H184	R:R:T263	5.48	No	No	12	3	3
165	R:R:T185	R:R:W188	6.06	No	No	0	2	5
166	R:R:F186	R:R:Q187	5.86	No	No	0	4	2
167	R:R:F186	R:R:W188	14.03	No	No	0	4	5
168	R:R:A191	R:R:Q187	6.06	No	No	0	3	2
169	R:R:F255	R:R:Q187	8.2	No	No	0	5	2
170	R:R:E190	R:R:R251	8.14	No	Yes	3	4	5
171	R:R:E190	R:R:F255	12.83	No	No	3	4	5
172	R:R:E196	R:R:M192	5.41	No	No	0	5	5
173	R:R:F193	R:R:S247	5.28	No	No	0	6	6
174	R:R:F193	R:R:R251	7.48	No	Yes	0	6	5
175	R:R:F198	R:R:L194	3.65	No	No	0	5	4
176	R:R:L194	R:R:V248	2.98	No	No	0	4	8
177	R:R:L195	R:R:L199	6.92	No	No	0	4	4
178	R:R:F197	R:R:F198	4.29	Yes	No	0	8	5
179	R:R:F197	R:R:L201	12.18	Yes	Yes	0	8	7
180	R:R:F197	R:R:F240	5.36	Yes	No	11	8	9
181	R:R:F197	R:R:F244	3.22	Yes	Yes	11	8	8
182	R:R:F197	R:R:L245	4.87	Yes	No	0	8	6
183	R:R:L199	R:R:P200	3.28	No	No	0	4	9
184	R:R:L201	R:R:V241	4.47	Yes	No	0	7	5
185	R:R:F240	R:R:I204	7.54	No	No	0	9	8
186	R:R:F206	R:R:R210	5.34	No	Yes	0	4	4
187	R:R:I233	R:R:S208	3.1	No	No	0	7	8
188	R:R:I212	R:R:R216	3.76	No	No	0	5	4
189	R:R:I212	R:R:I230	7.36	No	No	0	5	6
190	R:R:I212	R:R:M234	2.92	No	No	0	5	4
191	R:R:Q217	R:R:W213	9.86	No	No	0	5	3
192	R:R:I226	R:R:L215	2.85	No	Yes	0	6	8
193	R:R:I230	R:R:L215	2.85	No	Yes	0	6	8
194	R:R:D221	R:R:R216	7.15	No	No	0	3	4
195	R:R:M220	R:R:R218	4.96	No	No	0	3	5
196	R:R:D221	R:R:R222	11.91	No	No	0	3	3
197	R:R:H223	R:R:K225	11.79	No	No	0	4	5
198	R:R:F232	R:R:R228	5.34	No	No	0	7	7
199	R:R:P299	R:R:R228	8.65	No	No	0	5	7
200	R:R:F232	R:R:S297	6.61	No	No	0	7	6
201	R:R:I238	R:R:M234	2.92	No	No	0	5	4
202	R:R:V236	R:R:Y294	8.83	No	Yes	0	8	9
203	R:R:I238	R:R:I242	2.94	No	No	0	5	5
204	R:R:L289	R:R:V239	2.98	No	No	0	7	7
205	R:R:F240	R:R:F244	4.29	No	Yes	11	9	8
206	R:R:L245	R:R:V241	2.98	No	No	0	6	5
207	R:R:C243	R:R:N286	3.15	No	No	0	8	9
208	R:R:F244	R:R:T283	3.89	Yes	No	0	8	8
209	R:R:F244	R:R:N286	8.46	Yes	No	0	8	9
210	R:R:P246	R:R:T279	5.25	No	No	0	9	7
211	R:R:S247	R:R:T279	3.2	No	No	0	6	7
212	R:R:S247	R:R:T283	3.2	No	No	0	6	8
213	R:R:A275	R:R:V250	3.39	No	No	0	5	5
214	R:R:F276	R:R:V250	6.55	No	No	0	4	5
215	R:R:T279	R:R:V250	6.35	No	No	0	7	5
216	R:R:I254	R:R:R251	6.26	No	Yes	0	4	5
217	R:R:F255	R:R:R251	5.34	No	Yes	3	5	5
218	R:R:F276	R:R:R251	8.55	No	Yes	3	4	5
219	R:R:R253	R:R:W256	3	No	No	0	5	4
220	R:R:L257	R:R:R253	3.64	No	No	0	3	5
221	R:R:I254	R:R:V272	3.07	No	No	0	4	4
222	R:R:T260	R:R:W256	6.06	No	No	0	1	4
223	R:R:L258	R:R:T263	5.9	No	No	12	3	3
224	R:R:T263	R:R:Y269	3.75	No	Yes	0	3	2
225	R:R:E267	R:R:N265	14.46	No	No	0	2	5
226	R:R:V272	R:R:Y269	3.79	No	Yes	0	4	2
227	R:R:D273	R:R:F277	7.17	No	No	0	4	5
228	R:R:I278	R:R:L274	2.85	Yes	No	0	6	1
229	R:R:I278	R:R:S281	3.1	Yes	No	6	6	6
230	R:R:L280	R:R:T283	2.95	No	No	0	5	8
231	R:R:M285	R:R:M288	5.78	No	Yes	5	5	8
232	R:R:L289	R:R:M285	4.24	No	No	5	7	5
233	R:R:D290	R:R:N286	12.12	No	No	0	9	9
234	R:R:L289	R:R:M288	4.24	No	Yes	5	7	8
235	R:R:Y294	R:R:Y295	2.98	Yes	Yes	2	9	7
236	R:R:P299	R:R:S298	10.69	No	No	0	5	8
237	R:R:L75	R:R:M109	2.83	No	Yes	0	6	5
238	R:R:L102	R:R:M106	2.83	No	No	0	5	5
239	R:R:L104	R:R:M103	2.83	Yes	No	0	5	5
240	R:R:L215	R:R:M220	2.83	Yes	No	0	8	3
241	R:R:P31	R:R:Y87	2.78	No	No	0	6	6
242	R:R:L201	R:R:L205	2.77	Yes	No	0	7	4
243	R:R:I116	R:R:Q112	2.74	No	No	0	5	7
244	R:R:F65	R:R:S148	2.64	No	No	0	7	8
245	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
246	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
247	R:R:V268	R:R:Y269	2.52	No	Yes	0	1	2
248	R:R:F282	R:R:I278	2.51	No	Yes	0	7	6
249	R:R:K60	R:R:R63	2.48	No	No	0	7	7
250	R:R:F95	R:R:K94	2.48	Yes	No	0	7	3
251	R:R:F296	R:R:L47	2.44	No	No	0	8	6
252	R:R:T155	R:R:W152	2.43	No	Yes	0	7	9
253	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
254	R:R:G172	R:R:G173	2.11	No	No	0	3	4
255	R:R:R210	R:R:W213	2	Yes	No	0	4	3
256	R:R:A72	R:R:G113	1.95	No	No	0	8	7
257	R:R:A48	R:R:P291	1.87	No	No	0	9	9
258	R:R:G153	R:R:I156	1.76	No	No	0	4	4
259	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
260	R:R:G46	R:R:N45	1.7	No	Yes	0	4	9
261	R:R:M84	R:R:P81	1.68	No	No	0	7	8
262	R:R:C207	R:R:I203	1.64	No	No	0	8	7
263	R:R:N45	R:R:P291	1.63	Yes	No	0	9	9
264	R:R:S181	R:R:V20	1.62	No	No	0	4	2
265	R:R:A122	R:R:I204	1.62	No	No	0	9	8
266	R:R:S214	R:R:V130	1.62	No	Yes	0	5	8
267	R:R:A237	R:R:I238	1.62	No	No	0	7	5
268	R:R:A224	R:R:K225	1.61	No	No	0	3	5
269	R:R:V235	R:R:V239	1.6	No	No	0	5	7
270	R:R:V236	R:R:V293	1.6	No	No	0	8	8
271	R:R:V292	R:R:V293	1.6	No	No	0	6	8
272	R:R:I204	R:R:S208	1.55	No	No	0	8	8
273	R:R:I156	R:R:V160	1.54	No	No	0	4	4
274	R:R:I252	R:R:V248	1.54	No	No	0	6	8
275	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
276	R:R:F38	R:R:G35	1.51	No	No	0	7	5
277	R:R:F40	R:R:G41	1.51	No	No	0	6	8
278	R:R:L69	R:R:S114	1.5	No	No	0	9	9
279	R:R:L257	R:R:V268	1.49	No	No	0	3	1
280	R:R:L257	R:R:V272	1.49	No	No	0	3	4
281	R:R:A135	R:R:H134	1.46	No	Yes	0	5	4
282	R:R:K165	R:R:M167	1.44	No	No	0	4	3
283	R:R:I39	R:R:L36	1.43	No	No	0	5	4
284	R:R:I154	R:R:L150	1.43	No	No	0	5	4
285	R:R:I154	R:R:L158	1.43	No	No	0	5	5
286	R:R:I64	R:R:N141	1.42	No	No	0	7	2
287	R:R:K57	R:R:L56	1.41	No	No	0	5	5
288	R:R:K16	R:R:N17	1.4	No	No	0	4	5
289	R:R:C53	R:R:F54	1.4	No	No	0	4	4
290	R:R:D14	R:R:K15	1.38	No	No	0	5	3
291	R:R:D221	R:R:K227	1.38	No	No	0	3	4
292	R:R:H55	R:R:I51	1.33	No	No	0	5	7
293	R:R:H223	R:R:I226	1.33	No	No	0	4	6
294	R:R:R142	R:R:S140	1.32	No	No	0	4	6
295	R:R:E12	R:R:N17	1.31	No	No	0	5	5
296	R:R:F67	R:R:V71	1.31	No	No	0	6	6
297	R:R:F232	R:R:T231	1.3	No	No	0	7	6
298	R:R:H134	R:R:N137	1.28	Yes	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F21	6.955	4	0	2
2	R:R:L30	4.132	5	6	5
3	R:R:E37	4.5025	4	5	7
4	R:R:N45	4.0175	4	0	9
5	R:R:L76	8.03	4	0	7
6	R:R:W91	8.845	4	0	4
7	R:R:W93	6.27833	6	0	9
8	R:R:F95	7.1675	4	8	7
9	R:R:L104	5.345	4	10	5
10	R:R:M109	4.7375	4	0	5
11	R:R:Y126	5.37333	6	1	7
12	R:R:F127	4.154	5	1	5
13	R:R:V130	6.615	4	1	8
14	R:R:H131	4.72	5	1	7
15	R:R:H134	4.16	5	1	4
16	R:R:W152	5.134	5	7	9
17	R:R:C183	4.3425	4	4	1
18	R:R:F197	5.984	5	11	8
19	R:R:L201	5.2825	4	0	7
20	R:R:R210	3.845	4	1	4
21	R:R:L215	2.8775	4	0	8
22	R:R:F244	5.39333	6	11	8
23	R:R:R251	6.49667	6	3	5
24	R:R:Y269	4.268	5	0	2
25	R:R:I278	2.8275	4	6	6
26	R:R:M288	4.765	4	5	8
27	R:R:Y294	5.68333	6	2	9
28	R:R:Y295	5.806	5	2	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C266	R:R:F10	11.9289	5.59	No	No	0	7	7
2	R:R:C19	R:R:C266	14.2688	7.28	No	No	0	4	7
3	R:R:C19	R:R:F21	14.5217	4.19	No	Yes	0	4	2
4	R:R:C19	R:R:Y269	19.1225	4.03	No	Yes	0	4	2
5	R:R:V272	R:R:Y269	50.3162	3.79	No	Yes	0	4	2
6	R:R:I254	R:R:V272	56.4111	3.07	No	No	0	4	4
7	R:R:I254	R:R:R251	57.3992	6.26	No	Yes	0	4	5
8	R:R:F255	R:R:R251	31.6443	5.34	No	Yes	3	5	5
9	R:R:F255	R:R:Q187	29.8656	8.2	No	No	0	5	2
10	R:R:F186	R:R:Q187	26.2451	5.86	No	No	0	4	2
11	R:R:F186	R:R:W188	24.2925	14.03	No	No	0	4	5
12	R:R:T185	R:R:W188	22.3162	6.06	No	No	0	2	5
13	R:R:C183	R:R:T185	20.3478	3.38	Yes	No	0	1	2
14	R:R:C183	R:R:I13	12.3083	3.27	Yes	No	4	1	3
15	R:R:I13	R:R:I169	10.3715	2.94	No	No	0	3	1
16	R:R:L104	R:R:M103	14.6798	2.83	Yes	No	0	5	5
17	R:R:M103	R:R:W93	21.1858	3.49	No	Yes	0	5	9
18	R:R:N86	R:R:W93	18.9486	7.91	No	Yes	0	5	9
19	R:R:N86	R:R:W91	20.2451	5.65	No	Yes	0	5	4
20	R:R:F277	R:R:W91	32.6324	15.03	No	Yes	0	5	4
21	R:R:D273	R:R:F277	33.0909	7.17	No	No	0	4	5
22	R:R:R22	R:R:W91	10.0632	10	No	Yes	0	3	4
23	R:R:I26	R:R:W91	13.6996	4.7	No	Yes	0	5	4
24	R:R:I26	R:R:L30	13.9447	7.14	No	Yes	0	5	5
25	R:R:L30	R:R:Y87	26.5771	4.69	Yes	No	0	5	6
26	R:R:L83	R:R:Y87	30.087	5.86	No	No	0	6	6
27	R:R:L80	R:R:L83	58.9802	4.15	No	No	0	8	6
28	R:R:L76	R:R:L80	64.7352	5.54	Yes	No	0	7	8
29	R:R:L76	R:R:Y284	27.3281	8.21	Yes	No	0	7	7
30	R:R:E37	R:R:Y284	25.3202	5.61	Yes	No	0	7	7
31	R:R:L34	R:R:L80	13.1304	4.15	No	No	0	8	8
32	R:R:L34	R:R:M84	10.9802	4.24	No	No	0	8	7
33	R:R:E37	R:R:M288	12.751	4.06	Yes	Yes	5	7	8
34	R:R:F193	R:R:R251	72.2292	7.48	No	Yes	0	6	5
35	R:R:F193	R:R:R111	71.6759	12.83	No	No	0	6	8
36	R:R:F244	R:R:R111	95.8577	7.48	Yes	No	0	8	8
37	R:R:F244	R:R:N286	100	8.46	Yes	No	0	8	9
38	R:R:D290	R:R:N286	99.083	12.12	No	No	0	9	9
39	R:R:D290	R:R:D73	86.5692	3.99	No	No	0	9	9
40	R:R:D73	R:R:P291	22.6798	6.44	No	No	0	9	9
41	R:R:N45	R:R:P291	18.6482	1.63	Yes	No	0	9	9
42	R:R:D290	R:R:L69	39.1383	4.07	No	No	0	9	9
43	R:R:L69	R:R:Y295	35.3755	3.52	No	Yes	0	9	7
44	R:R:F52	R:R:Y295	12.0474	10.32	No	Yes	0	7	7
45	R:R:E196	R:R:R111	74.3715	10.47	No	No	0	5	8
46	R:R:E196	R:R:Q112	71.3518	14.02	No	No	0	5	7
47	R:R:I116	R:R:Q112	65.1225	2.74	No	No	0	5	7
48	R:R:I116	R:R:L151	63.5257	5.71	No	No	0	5	7
49	R:R:F117	R:R:L151	60.2846	6.09	No	No	0	8	7
50	R:R:F117	R:R:N68	22.5929	14.5	No	No	7	8	9
51	R:R:N68	R:R:S148	22.4348	8.94	No	No	0	9	8
52	R:R:F65	R:R:S148	20.4585	2.64	No	No	0	7	8
53	R:R:F65	R:R:S61	16.4585	5.28	No	No	0	7	6
54	R:R:N137	R:R:R128	11.7787	6.03	No	No	0	4	8
55	R:R:H134	R:R:N137	15.7866	1.28	Yes	No	0	4	4
56	R:R:F127	R:R:H134	11.6996	5.66	Yes	Yes	1	5	4
57	R:R:F127	R:R:Y126	17.5336	3.09	Yes	Yes	1	5	7
58	R:R:C207	R:R:Y126	77.1541	6.72	No	Yes	0	8	7
59	R:R:C207	R:R:I203	78.5692	1.64	No	No	0	8	7
60	R:R:I203	R:R:T119	79.9684	4.56	No	No	0	7	7
61	R:R:P200	R:R:T119	81.3518	3.5	No	No	0	9	7
62	R:R:I115	R:R:P200	85.4071	3.39	No	No	0	8	9
63	R:R:F244	R:R:I115	86.7273	5.02	Yes	No	0	8	8
64	R:R:H131	R:R:H134	12.0395	5.97	Yes	Yes	1	7	4
65	R:R:H131	R:R:Y126	17.4862	3.27	Yes	Yes	1	7	7
66	R:R:Y294	R:R:Y295	13.9842	2.98	Yes	Yes	2	9	7
67	R:R:F117	R:R:W152	36.0395	8.02	No	Yes	7	8	9
68	R:R:L76	R:R:S287	76.1186	6.01	Yes	No	0	7	8
69	R:R:D73	R:R:S287	76.8933	5.89	No	No	0	9	8
70	R:R:C79	R:R:M103	27.6917	3.24	No	No	0	6	5
71	R:R:L107	R:R:L83	31.9368	4.15	No	No	0	6	6
72	R:R:C79	R:R:L107	30.3953	4.76	No	No	0	6	6
73	R:R:M109	R:R:W152	30.3478	6.98	Yes	Yes	0	5	9
74	R:R:F105	R:R:M109	20.6245	6.22	No	Yes	0	6	5
75	R:R:F105	R:R:L163	14.6008	7.31	No	No	0	6	5
76	R:R:L163	R:R:R101	12.5613	12.15	No	No	0	5	6
77	R:R:I98	R:R:R101	10.5059	8.77	No	No	0	2	6
78	R:R:I211	R:R:Y126	36.9881	2.42	No	Yes	0	8	7
79	R:R:I211	R:R:V129	35.1541	9.22	No	No	0	8	8
80	R:R:L215	R:R:V129	33.2885	2.98	Yes	No	0	8	8
81	R:R:I182	R:R:Y269	29.6047	7.25	No	Yes	0	3	2
82	R:R:F197	R:R:F244	21.9051	3.22	Yes	Yes	11	8	8
83	R:R:I230	R:R:L215	20.0949	2.85	No	Yes	0	6	8
84	R:R:I212	R:R:I230	18.2767	7.36	No	No	0	5	6
85	R:R:D273	R:R:I182	28.6008	7	No	No	0	4	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8IJ3_nogp

PDB Summary
PDB	8IJ3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	274
Number of Links	298
Number of Hubs	28
Number of Links mediated by Hubs	114
Number of Communities	12
Number of Nodes involved in Communities	46
Number of Links involved in Communities	54

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	36394
Length Of Smallest Path	3
Average Path Length	14.3961
Length of Longest Path	30
Minimum Path Strength	1.355
Average Path Strength	5.87852
Maximum Path Strength	17.355
Minimum Path Correlation	0.7
Average Path Correlation	0.923056
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	48.003
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	23.9894
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • cellular process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • protein localization • positive regulation of cell communication • regulation of localization • establishment of protein localization • system process • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • cellular macromolecule localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • cellular localization • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • regulation of cellular localization • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • cellular anatomical structure • cell junction • cell periphery • plasma membrane • membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8IJ3_nogp_Chain_R D H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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