psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	10.76	Yes	No	0	0	6
2	L:L:?1	R:R:Y87	3.04	Yes	No	1	0	6
3	L:L:?1	R:R:L104	8.96	Yes	No	0	0	5
4	L:L:?1	R:R:L107	8.07	Yes	No	0	0	6
5	L:L:?1	R:R:A108	6.12	Yes	No	0	0	4
6	L:L:?1	R:R:R111	8.65	Yes	No	0	0	8
7	L:L:?1	R:R:Q112	7.76	Yes	No	1	0	7
8	L:L:?1	R:R:L158	3.59	Yes	No	0	0	5
9	L:L:?1	R:R:H161	4.16	Yes	No	1	0	7
10	L:L:?1	R:R:L162	7.17	Yes	No	1	0	4
11	L:L:?1	R:R:S179	3.89	Yes	No	0	0	4
12	L:L:?1	R:R:F180	17.35	Yes	No	1	0	3
13	L:L:?1	R:R:H189	12.49	Yes	Yes	1	0	5
14	L:L:?1	R:R:E196	6.01	Yes	Yes	1	0	5
15	L:L:?1	R:R:F277	3.94	Yes	No	0	0	5
16	L:L:?1	R:R:L280	5.38	Yes	No	0	0	5
17	L:L:?1	R:R:Y284	5.31	Yes	No	0	0	7
18	R:R:D14	R:R:I13	8.4	Yes	No	0	5	3
19	R:R:D14	R:R:K16	4.15	Yes	Yes	1	5	4
20	R:R:C18	R:R:D14	6.22	Yes	Yes	1	9	5
21	R:R:D14	R:R:I169	4.2	Yes	No	0	5	1
22	R:R:C18	R:R:K16	3.23	Yes	Yes	1	9	4
23	R:R:C183	R:R:K16	3.23	No	Yes	1	1	4
24	R:R:K16	R:R:T185	13.51	Yes	No	1	4	2
25	R:R:K16	R:R:Q187	5.42	Yes	Yes	1	4	2
26	R:R:C18	R:R:S181	3.44	Yes	No	1	9	4
27	R:R:C18	R:R:C183	7.28	Yes	No	1	9	1
28	R:R:C19	R:R:F21	5.59	No	No	0	4	2
29	R:R:C19	R:R:C266	3.64	No	No	0	4	7
30	R:R:L176	R:R:V20	4.47	No	No	0	4	2
31	R:R:D273	R:R:F21	10.75	No	No	0	4	2
32	R:R:R22	R:R:R90	9.6	No	No	5	3	4
33	R:R:R22	R:R:W91	8	No	No	5	3	4
34	R:R:N171	R:R:R22	8.44	No	No	0	1	3
35	R:R:D23	R:R:F25	4.78	No	Yes	1	4	6
36	R:R:D23	R:R:R270	4.76	No	No	0	4	1
37	R:R:D23	R:R:L274	5.43	No	No	1	4	1
38	R:R:F25	R:R:L274	4.87	Yes	No	1	6	1
39	R:R:I26	R:R:L30	7.14	No	No	1	5	5
40	R:R:I26	R:R:Y87	4.84	No	No	1	5	6
41	R:R:K28	R:R:V27	3.04	No	No	0	3	3
42	R:R:R90	R:R:V27	3.92	No	No	0	4	3
43	R:R:L30	R:R:Y87	7.03	No	No	1	5	6
44	R:R:P31	R:R:P32	7.79	No	No	0	6	5
45	R:R:E37	R:R:L34	3.98	Yes	Yes	0	7	8
46	R:R:L34	R:R:L80	4.15	Yes	No	0	8	8
47	R:R:L34	R:R:M84	5.65	Yes	No	0	8	7
48	R:R:E37	R:R:Y284	7.86	Yes	No	0	7	7
49	R:R:E37	R:R:M288	4.06	Yes	No	0	7	8
50	R:R:F38	R:R:L42	8.53	No	No	0	7	7
51	R:R:F40	R:R:M288	6.22	No	No	0	6	8
52	R:R:I77	R:R:L42	7.14	No	No	0	6	7
53	R:R:D73	R:R:N45	16.16	No	No	0	9	9
54	R:R:N45	R:R:P291	14.66	No	No	0	9	9
55	R:R:I51	R:R:L47	5.71	No	No	0	7	6
56	R:R:F296	R:R:L47	6.09	No	No	0	8	6
57	R:R:A48	R:R:Y295	5.34	No	Yes	0	9	7
58	R:R:C53	R:R:L49	3.17	No	No	0	4	7
59	R:R:H55	R:R:I51	3.98	No	No	0	5	7
60	R:R:F52	R:R:Y295	12.38	No	Yes	0	7	7
61	R:R:F54	R:R:H55	4.53	No	No	0	4	5
62	R:R:R63	R:R:S58	7.91	Yes	No	0	7	6
63	R:R:F67	R:R:W59	12.03	No	No	0	6	6
64	R:R:K60	R:R:S62	6.12	No	No	6	7	8
65	R:R:K60	R:R:R63	6.19	No	Yes	6	7	7
66	R:R:F65	R:R:S61	3.96	No	No	0	7	6
67	R:R:I139	R:R:S61	3.1	No	No	0	7	6
68	R:R:A144	R:R:S61	3.42	No	No	0	7	6
69	R:R:R63	R:R:S62	9.22	Yes	No	6	7	8
70	R:R:A144	R:R:I64	3.25	No	No	0	7	7
71	R:R:F65	R:R:V120	7.87	No	No	0	7	7
72	R:R:L66	R:R:V121	4.47	No	No	0	8	9
73	R:R:L66	R:R:Y295	7.03	No	Yes	0	8	7
74	R:R:F67	R:R:N68	6.04	No	Yes	0	6	9
75	R:R:F117	R:R:N68	3.62	Yes	Yes	2	8	9
76	R:R:N68	R:R:S148	10.43	Yes	No	0	9	8
77	R:R:N68	R:R:W152	4.52	Yes	No	2	9	9
78	R:R:F117	R:R:L69	6.09	Yes	Yes	2	8	9
79	R:R:L118	R:R:L69	4.15	Yes	Yes	2	9	9
80	R:R:L69	R:R:Y295	4.69	Yes	Yes	0	9	7
81	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
82	R:R:D73	R:R:S287	10.31	No	No	0	9	8
83	R:R:D290	R:R:D73	3.99	Yes	No	0	9	9
84	R:R:L75	R:R:M106	4.24	No	No	3	6	5
85	R:R:L75	R:R:N110	6.87	No	No	3	6	9
86	R:R:L76	R:R:N110	6.87	No	No	0	7	9
87	R:R:L76	R:R:S287	7.51	No	No	0	7	8
88	R:R:C79	R:R:F82	4.19	Yes	No	3	6	6
89	R:R:C79	R:R:M103	3.24	Yes	Yes	3	6	5
90	R:R:C79	R:R:M106	8.1	Yes	No	3	6	5
91	R:R:C79	R:R:L107	3.17	Yes	No	0	6	6
92	R:R:F82	R:R:P81	10.11	No	No	0	6	8
93	R:R:F82	R:R:M103	4.98	No	Yes	3	6	5
94	R:R:M84	R:R:V88	4.56	No	No	0	7	3
95	R:R:D85	R:R:K94	5.53	No	No	0	4	3
96	R:R:N86	R:R:W91	5.65	No	No	0	5	4
97	R:R:D92	R:R:R89	4.76	No	No	0	4	4
98	R:R:K94	R:R:R89	17.33	No	No	0	3	4
99	R:R:R90	R:R:W91	9	No	No	5	4	4
100	R:R:A174	R:R:D92	3.09	No	No	0	2	4
101	R:R:F95	R:R:W93	6.01	No	Yes	0	7	9
102	R:R:C100	R:R:W93	6.53	No	Yes	0	9	9
103	R:R:M103	R:R:W93	3.49	Yes	Yes	3	5	9
104	R:R:P168	R:R:W93	9.46	No	Yes	3	4	9
105	R:R:N175	R:R:W93	7.91	No	Yes	3	4	9
106	R:R:F95	R:R:K94	6.2	No	No	0	7	3
107	R:R:F95	R:R:P99	7.22	No	No	0	7	5
108	R:R:G96	R:R:P99	4.06	No	No	0	7	5
109	R:R:D97	R:R:R101	15.48	No	No	0	3	6
110	R:R:D97	R:R:M167	6.93	No	No	0	3	3
111	R:R:I98	R:R:P99	3.39	No	No	0	2	5
112	R:R:C100	R:R:C177	7.28	No	No	0	9	9
113	R:R:L104	R:R:M103	7.07	No	Yes	0	5	5
114	R:R:F105	R:R:M109	6.22	No	Yes	2	6	5
115	R:R:F105	R:R:T159	10.38	No	No	2	6	7
116	R:R:F105	R:R:L163	15.83	No	No	0	6	5
117	R:R:M106	R:R:N110	4.21	No	No	3	5	9
118	R:R:M109	R:R:W152	6.98	Yes	No	2	5	9
119	R:R:M109	R:R:T159	4.52	Yes	No	2	5	7
120	R:R:F193	R:R:R111	4.28	No	No	0	6	8
121	R:R:Q112	R:R:T155	8.5	No	No	0	7	7
122	R:R:E196	R:R:Q112	17.84	Yes	No	1	5	7
123	R:R:I115	R:R:P200	3.39	No	No	0	8	9
124	R:R:F244	R:R:I115	7.54	Yes	No	0	8	8
125	R:R:I116	R:R:L151	4.28	No	No	0	5	7
126	R:R:F117	R:R:L151	3.65	Yes	No	0	8	7
127	R:R:F117	R:R:W152	10.02	Yes	No	2	8	9
128	R:R:D290	R:R:L118	4.07	Yes	Yes	2	9	9
129	R:R:L118	R:R:Y294	3.52	Yes	Yes	2	9	9
130	R:R:P200	R:R:T119	3.5	No	No	0	9	7
131	R:R:I203	R:R:T119	4.56	No	No	0	7	7
132	R:R:I204	R:R:T119	3.04	No	No	0	8	7
133	R:R:R125	R:R:V121	5.23	No	No	2	9	9
134	R:R:V121	R:R:Y294	5.05	No	Yes	2	9	9
135	R:R:A122	R:R:I204	3.25	No	No	0	9	8
136	R:R:D124	R:R:R128	14.29	No	No	0	8	8
137	R:R:R125	R:R:Y294	8.23	No	Yes	2	9	9
138	R:R:F127	R:R:Y126	5.16	Yes	Yes	4	5	7
139	R:R:V130	R:R:Y126	12.62	Yes	Yes	4	8	7
140	R:R:C207	R:R:Y126	8.06	No	Yes	0	8	7
141	R:R:R210	R:R:Y126	6.17	Yes	Yes	4	4	7
142	R:R:F127	R:R:H131	3.39	Yes	No	0	5	7
143	R:R:F127	R:R:H134	6.79	Yes	Yes	4	5	4
144	R:R:F127	R:R:L136	3.65	Yes	No	4	5	4
145	R:R:N137	R:R:R128	3.62	No	No	0	4	8
146	R:R:I211	R:R:V129	4.61	No	No	0	8	8
147	R:R:H131	R:R:V130	5.54	No	Yes	0	7	8
148	R:R:R210	R:R:V130	3.92	Yes	Yes	4	4	8
149	R:R:S214	R:R:V130	6.46	No	Yes	0	5	8
150	R:R:H133	R:R:P132	4.58	No	No	0	6	8
151	R:R:H134	R:R:L136	5.14	Yes	No	4	4	4
152	R:R:I139	R:R:T143	6.08	No	No	0	7	3
153	R:R:R142	R:R:S140	3.95	No	No	7	4	6
154	R:R:S140	R:R:T143	4.8	No	No	7	6	3
155	R:R:R142	R:R:T143	6.47	No	No	7	4	3
156	R:R:I146	R:R:R142	7.52	No	No	0	3	4
157	R:R:G153	R:R:I156	3.53	No	No	0	4	4
158	R:R:I154	R:R:L158	5.71	No	No	0	5	5
159	R:R:T155	R:R:T159	3.14	No	No	0	7	7
160	R:R:G157	R:R:I156	3.53	No	No	0	5	4
161	R:R:G157	R:R:V160	3.68	No	No	0	5	4
162	R:R:H161	R:R:L162	9	No	No	1	7	4
163	R:R:H161	R:R:W188	12.7	No	No	0	7	5
164	R:R:M167	R:R:P168	3.35	No	No	0	3	4
165	R:R:N175	R:R:P168	8.15	No	No	3	4	4
166	R:R:L176	R:R:N171	12.36	No	No	0	4	1
167	R:R:F180	R:R:H189	4.53	No	Yes	1	3	5
168	R:R:F180	R:R:F276	7.5	No	Yes	0	3	4
169	R:R:C183	R:R:S181	3.44	No	No	1	1	4
170	R:R:D273	R:R:I182	8.4	No	No	0	4	3
171	R:R:H184	R:R:L258	15.43	No	No	0	3	3
172	R:R:Q187	R:R:T185	8.5	Yes	No	1	2	2
173	R:R:F186	R:R:F255	3.22	No	Yes	0	4	5
174	R:R:H189	R:R:Q187	9.89	Yes	Yes	1	5	2
175	R:R:E190	R:R:Q187	5.1	Yes	Yes	1	4	2
176	R:R:E190	R:R:H189	12.31	Yes	Yes	1	4	5
177	R:R:E190	R:R:R251	9.3	Yes	Yes	1	4	5
178	R:R:E190	R:R:F255	5.83	Yes	Yes	1	4	5
179	R:R:L195	R:R:M192	4.24	No	No	0	4	5
180	R:R:E196	R:R:M192	10.83	Yes	No	0	5	5
181	R:R:E196	R:R:F193	4.66	Yes	No	0	5	6
182	R:R:F197	R:R:F198	4.29	Yes	No	0	8	5
183	R:R:F197	R:R:L201	3.65	Yes	No	8	8	7
184	R:R:F197	R:R:F240	4.29	Yes	No	8	8	9
185	R:R:F197	R:R:L245	4.87	Yes	No	0	8	6
186	R:R:F197	R:R:V248	14.42	Yes	No	0	8	8
187	R:R:L199	R:R:P200	6.57	No	No	0	4	9
188	R:R:I203	R:R:L199	4.28	No	No	0	7	4
189	R:R:F240	R:R:L201	6.09	No	No	8	9	7
190	R:R:F206	R:R:R210	7.48	No	Yes	0	4	4
191	R:R:I212	R:R:I230	4.42	No	No	0	5	6
192	R:R:Q217	R:R:W213	10.95	No	No	0	5	3
193	R:R:L215	R:R:Q219	5.32	No	No	0	8	3
194	R:R:L215	R:R:M220	4.24	No	Yes	0	8	3
195	R:R:M220	R:R:R216	3.72	Yes	No	0	3	4
196	R:R:Q219	R:R:R218	9.35	No	No	0	3	5
197	R:R:I226	R:R:M220	4.37	No	Yes	0	6	3
198	R:R:K227	R:R:M220	4.32	No	Yes	0	4	3
199	R:R:I230	R:R:M220	7.29	No	Yes	0	6	3
200	R:R:H223	R:R:I226	5.3	No	No	0	4	6
201	R:R:F232	R:R:R228	4.28	No	No	0	7	7
202	R:R:P299	R:R:R228	14.41	No	No	0	5	7
203	R:R:F232	R:R:S297	13.21	No	No	0	7	6
204	R:R:V236	R:R:V293	3.21	No	No	0	8	8
205	R:R:V236	R:R:Y294	11.36	No	Yes	0	8	9
206	R:R:L289	R:R:V239	4.47	No	No	0	7	7
207	R:R:F240	R:R:F244	3.22	No	Yes	0	9	8
208	R:R:C243	R:R:I242	3.27	No	No	0	8	5
209	R:R:C243	R:R:M285	3.24	No	No	0	8	5
210	R:R:C243	R:R:N286	3.15	No	Yes	0	8	9
211	R:R:F244	R:R:T283	3.89	Yes	No	0	8	8
212	R:R:F244	R:R:N286	6.04	Yes	Yes	0	8	9
213	R:R:F282	R:R:P246	7.22	No	No	0	7	9
214	R:R:F276	R:R:S247	3.96	Yes	No	0	4	6
215	R:R:F276	R:R:V250	6.55	Yes	No	0	4	5
216	R:R:I254	R:R:R251	6.26	No	Yes	0	4	5
217	R:R:F255	R:R:R251	4.28	Yes	Yes	1	5	5
218	R:R:F276	R:R:R251	14.97	Yes	Yes	0	4	5
219	R:R:I254	R:R:V272	6.14	No	No	0	4	4
220	R:R:L257	R:R:Y269	7.03	Yes	No	0	3	2
221	R:R:L257	R:R:V272	4.47	Yes	No	0	3	4
222	R:R:G262	R:R:S261	3.71	No	No	0	4	3
223	R:R:Q264	R:R:S261	10.11	No	No	0	3	3
224	R:R:S261	R:R:Y269	7.63	No	No	0	3	2
225	R:R:E267	R:R:Q264	6.37	No	No	0	2	3
226	R:R:C266	R:R:Y269	17.47	No	No	0	7	2
227	R:R:R270	R:R:V268	3.92	No	No	0	1	1
228	R:R:R270	R:R:S271	5.27	No	No	0	1	3
229	R:R:D273	R:R:F277	9.55	No	No	0	4	5
230	R:R:F276	R:R:F277	4.29	Yes	No	0	4	5
231	R:R:F276	R:R:L280	4.87	Yes	No	0	4	5
232	R:R:F282	R:R:M285	6.22	No	No	0	7	5
233	R:R:D290	R:R:N286	5.39	Yes	Yes	0	9	9
234	R:R:D290	R:R:Y294	3.45	Yes	Yes	2	9	9
235	R:R:F74	R:R:G46	3.01	No	No	0	7	4
236	R:R:L49	R:R:V71	2.98	No	No	0	7	6
237	R:R:L151	R:R:V120	2.98	No	No	0	7	7
238	R:R:L245	R:R:V241	2.98	No	No	0	6	5
239	R:R:L245	R:R:V249	2.98	No	No	0	6	6
240	R:R:I156	R:R:M109	2.92	No	Yes	0	4	5
241	R:R:F296	R:R:P291	2.89	No	No	0	8	9
242	R:R:I26	R:R:L274	2.85	No	No	1	5	1
243	R:R:I252	R:R:L194	2.85	No	No	0	6	4
244	R:R:D24	R:R:K28	2.77	No	No	0	4	3
245	R:R:A72	R:R:F117	2.77	No	Yes	0	8	8
246	R:R:L289	R:R:N286	2.75	No	Yes	0	7	9
247	R:R:I13	R:R:Q170	2.74	No	No	0	3	1
248	R:R:H184	R:R:T263	2.74	No	No	0	3	3
249	R:R:F25	R:R:V29	2.62	Yes	No	0	6	5
250	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
251	R:R:F296	R:R:V292	2.62	No	No	0	8	6
252	R:R:H134	R:R:N137	2.55	Yes	No	0	4	4
253	R:R:F65	R:R:I147	2.51	No	No	0	7	5
254	R:R:F74	R:R:I78	2.51	No	No	0	7	6
255	R:R:F25	R:R:K28	2.48	Yes	No	0	6	3
256	R:R:F40	R:R:L36	2.44	No	No	0	6	4
257	R:R:F255	R:R:L258	2.44	Yes	No	0	5	3
258	R:R:L66	R:R:R63	2.43	No	Yes	0	8	7
259	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
260	R:R:D221	R:R:R222	2.38	No	No	0	3	3
261	R:R:G172	R:R:G173	2.11	No	No	0	3	4
262	R:R:G44	R:R:P291	2.03	No	No	0	7	9
263	R:R:F54	R:R:W50	2	No	No	0	4	4
264	R:R:R210	R:R:W213	2	Yes	No	0	4	3
265	R:R:R253	R:R:W256	2	No	No	0	5	4
266	L:L:?1	R:R:S178	1.94	Yes	No	0	0	4
267	R:R:P299	R:R:S298	1.78	No	No	0	5	8
268	R:R:P299	R:R:S300	1.78	No	No	0	5	5
269	R:R:G113	R:R:I116	1.76	No	No	0	7	5
270	R:R:G41	R:R:M288	1.75	No	No	0	8	8
271	R:R:P246	R:R:T279	1.75	No	No	0	9	7
272	R:R:G35	R:R:L34	1.71	No	Yes	0	5	8
273	R:R:G46	R:R:L49	1.71	No	No	0	4	7
274	R:R:G202	R:R:L201	1.71	No	No	0	3	7
275	R:R:G46	R:R:N45	1.7	No	No	0	4	9
276	R:R:A275	R:R:V250	1.7	No	No	0	5	5
277	R:R:M84	R:R:P31	1.68	No	No	0	7	6
278	R:R:C207	R:R:I203	1.64	No	No	0	8	7
279	R:R:A224	R:R:K227	1.61	No	No	0	3	4
280	R:R:V235	R:R:V239	1.6	No	No	0	5	7
281	R:R:V235	R:R:V293	1.6	No	No	0	5	8
282	R:R:I77	R:R:S287	1.55	No	No	0	6	8
283	R:R:I233	R:R:S208	1.55	No	No	0	7	8
284	R:R:I278	R:R:V29	1.54	No	No	0	6	5
285	R:R:I238	R:R:V241	1.54	No	No	0	5	5
286	R:R:I252	R:R:V248	1.54	No	No	0	6	8
287	R:R:H131	R:R:P132	1.53	No	No	0	7	8
288	R:R:I230	R:R:T231	1.52	No	No	0	6	6
289	R:R:L69	R:R:S114	1.5	Yes	No	2	9	9
290	R:R:L118	R:R:S114	1.5	Yes	No	2	9	9
291	R:R:L34	R:R:V33	1.49	Yes	No	0	8	5
292	R:R:L215	R:R:V129	1.49	No	No	0	8	8
293	R:R:L257	R:R:T260	1.47	Yes	No	0	3	1
294	R:R:A135	R:R:H134	1.46	No	Yes	0	5	4
295	R:R:E37	R:R:S281	1.44	Yes	No	0	7	6
296	R:R:K165	R:R:K166	1.44	No	No	0	4	4
297	R:R:I39	R:R:L43	1.43	No	No	0	5	4
298	R:R:I64	R:R:N141	1.42	No	No	0	7	2
299	R:R:K138	R:R:N137	1.4	No	No	0	4	4
300	R:R:F232	R:R:T231	1.3	No	No	0	7	6
301	R:R:I233	R:R:R125	1.25	No	No	0	7	9
302	R:R:K164	R:R:R101	1.24	No	No	0	4	6
303	R:R:L257	R:R:R253	1.21	Yes	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.92167	18	1	0
2	R:R:D14	5.7425	4	1	5
3	R:R:K16	5.908	5	1	4
4	R:R:C18	5.0425	4	1	9
5	R:R:F25	3.6875	4	1	6
6	R:R:L34	3.396	5	0	8
7	R:R:E37	4.335	4	0	7
8	R:R:R63	6.4375	4	6	7
9	R:R:N68	6.1525	4	2	9
10	R:R:L69	4.1075	4	2	9
11	R:R:C79	4.675	4	3	6
12	R:R:W93	6.68	5	3	9
13	R:R:M103	4.695	4	3	5
14	R:R:M109	5.16	4	2	5
15	R:R:F117	5.23	5	2	8
16	R:R:L118	3.31	4	2	9
17	R:R:Y126	6.886	5	4	7
18	R:R:F127	4.322	5	4	5
19	R:R:V130	7.135	4	4	8
20	R:R:H134	3.985	4	4	4
21	R:R:Q187	7.2275	4	1	2
22	R:R:H189	9.805	4	1	5
23	R:R:E190	8.135	4	1	4
24	R:R:E196	9.835	4	1	5
25	R:R:F197	6.304	5	8	8
26	R:R:R210	4.8925	4	4	4
27	R:R:M220	4.788	5	0	3
28	R:R:F244	5.1725	4	0	8
29	R:R:R251	8.7025	4	1	5
30	R:R:F255	3.9425	4	1	5
31	R:R:L257	3.545	4	0	3
32	R:R:F276	7.02333	6	0	4
33	R:R:N286	4.3325	4	0	9
34	R:R:D290	4.225	4	2	9
35	R:R:Y294	6.322	5	2	9
36	R:R:Y295	6.688	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H189	26.0813	12.49	Yes	Yes	1	0	5
2	R:R:H189	R:R:Q187	11.7293	9.89	Yes	Yes	1	5	2
3	R:R:K16	R:R:Q187	10.4123	5.42	Yes	Yes	1	4	2
4	L:L:?1	R:R:F277	23.1929	3.94	Yes	No	0	0	5
5	R:R:D273	R:R:F277	10.8014	9.55	No	No	0	4	5
6	L:L:?1	R:R:Y87	25.9166	3.04	Yes	No	1	0	6
7	R:R:I26	R:R:Y87	23.6456	4.84	No	No	1	5	6
8	R:R:I26	R:R:L274	22.5307	2.85	No	No	1	5	1
9	R:R:F25	R:R:L274	16.2938	4.87	Yes	No	1	6	1
10	R:R:F25	R:R:K28	12.7694	2.48	Yes	No	0	6	3
11	R:R:K28	R:R:V27	10.2552	3.04	No	No	0	3	3
12	L:L:?1	R:R:Y284	19.0213	5.31	Yes	No	0	0	7
13	R:R:E37	R:R:Y284	17.8053	7.86	Yes	No	0	7	7
14	R:R:E37	R:R:L34	10.3524	3.98	Yes	Yes	0	7	8
15	L:L:?1	R:R:L107	71.8161	8.07	Yes	No	0	0	6
16	R:R:C79	R:R:L107	71.8685	3.17	Yes	No	0	6	6
17	R:R:C79	R:R:M106	84.0654	8.1	Yes	No	3	6	5
18	R:R:M106	R:R:N110	83.5528	4.21	No	No	3	5	9
19	R:R:L76	R:R:N110	84.331	6.87	No	No	0	7	9
20	R:R:L76	R:R:S287	84.4582	7.51	No	No	0	7	8
21	R:R:D73	R:R:S287	84.9521	10.31	No	No	0	9	8
22	R:R:D73	R:R:N45	19.5712	16.16	No	No	0	9	9
23	R:R:N45	R:R:P291	11.2429	14.66	No	No	0	9	9
24	L:L:?1	R:R:Q112	26.6051	7.76	Yes	No	1	0	7
25	R:R:Q112	R:R:T155	29.1529	8.5	No	No	0	7	7
26	R:R:T155	R:R:T159	29.2614	3.14	No	No	0	7	7
27	R:R:M109	R:R:T159	28.2326	4.52	Yes	No	2	5	7
28	R:R:M109	R:R:W152	30.1444	6.98	Yes	No	2	5	9
29	R:R:F117	R:R:W152	27.9071	10.02	Yes	No	2	8	9
30	R:R:F117	R:R:L69	30.657	6.09	Yes	Yes	2	8	9
31	R:R:F117	R:R:L151	18.3403	3.65	Yes	No	0	8	7
32	R:R:L151	R:R:V120	14.771	2.98	No	No	0	7	7
33	R:R:F65	R:R:V120	13.5626	7.87	No	No	0	7	7
34	R:R:F65	R:R:S61	11.1456	3.96	No	No	0	7	6
35	R:R:D290	R:R:D73	85.8426	3.99	Yes	No	0	9	9
36	R:R:D290	R:R:Y294	10.8313	3.45	Yes	Yes	2	9	9
37	R:R:L118	R:R:L69	26.7136	4.15	Yes	Yes	2	9	9
38	L:L:?1	R:R:L104	13.0762	8.96	Yes	No	0	0	5
39	R:R:L104	R:R:M103	13.1024	7.07	No	Yes	0	5	5
40	R:R:M103	R:R:W93	22.0817	3.49	Yes	Yes	3	5	9
41	R:R:F95	R:R:W93	11.4113	6.01	No	Yes	0	7	9
42	R:R:D290	R:R:N286	100	5.39	Yes	Yes	0	9	9
43	R:R:F244	R:R:N286	96.1501	6.04	Yes	Yes	0	8	9
44	R:R:F244	R:R:I115	88.5551	7.54	Yes	No	0	8	8
45	R:R:I115	R:R:P200	87.9565	3.39	No	No	0	8	9
46	R:R:P200	R:R:T119	44.6386	3.5	No	No	0	9	7
47	R:R:I203	R:R:T119	42.2703	4.56	No	No	0	7	7
48	R:R:L199	R:R:P200	42.7305	6.57	No	No	0	4	9
49	R:R:I203	R:R:L199	41.941	4.28	No	No	0	7	4
50	R:R:C207	R:R:I203	82.4304	1.64	No	No	0	8	7
51	R:R:C207	R:R:Y126	80.6607	8.06	No	Yes	0	8	7
52	R:R:F127	R:R:Y126	24.3078	5.16	Yes	Yes	4	5	7
53	R:R:F127	R:R:H134	12.3429	6.79	Yes	Yes	4	5	4
54	R:R:V130	R:R:Y126	10.1092	12.62	Yes	Yes	4	8	7
55	R:R:I211	R:R:Y126	39.8346	2.42	No	Yes	0	8	7
56	R:R:I211	R:R:V129	37.8891	4.61	No	No	0	8	8
57	R:R:F276	R:R:F277	11.9276	4.29	Yes	No	0	4	5
58	L:L:?1	R:R:L280	12.7207	5.38	Yes	No	0	0	5
59	R:R:F276	R:R:L280	11.7517	4.87	Yes	No	0	4	5
60	R:R:E190	R:R:H189	13.6898	12.31	Yes	Yes	1	4	5
61	L:L:?1	R:R:F180	12.5224	17.35	Yes	No	1	0	3
62	R:R:F180	R:R:F276	11.8191	7.5	No	Yes	0	3	4
63	R:R:F276	R:R:R251	22.9572	14.97	Yes	Yes	0	4	5
64	R:R:F240	R:R:F244	15.0367	3.22	No	Yes	0	9	8
65	R:R:F197	R:R:F240	11.3102	4.29	Yes	No	8	8	9
66	R:R:L215	R:R:V129	35.9286	1.49	No	No	0	8	8
67	R:R:L215	R:R:M220	30.0397	4.24	No	Yes	0	8	3
68	R:R:I230	R:R:M220	18.041	7.29	No	Yes	0	6	3
69	R:R:I230	R:R:T231	14.1425	1.52	No	No	0	6	6
70	R:R:F232	R:R:T231	12.1034	1.3	No	No	0	7	6
71	R:R:I254	R:R:R251	26.5452	6.26	No	Yes	0	4	5
72	R:R:I254	R:R:V272	22.2463	6.14	No	No	0	4	4
73	R:R:L257	R:R:V272	17.9475	4.47	Yes	No	0	3	4
74	R:R:C79	R:R:M103	12.3204	3.24	Yes	Yes	3	6	5
75	R:R:D290	R:R:L118	22.931	4.07	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	10.76	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y87	3.04	1	Yes	No	0	6	0	1
L:L:?1	R:R:L104	8.96	1	Yes	No	0	5	0	1
L:L:?1	R:R:L107	8.07	1	Yes	No	0	6	0	1
L:L:?1	R:R:A108	6.12	1	Yes	No	0	4	0	1
L:L:?1	R:R:R111	8.65	1	Yes	No	0	8	0	1
L:L:?1	R:R:Q112	7.76	1	Yes	No	0	7	0	1
L:L:?1	R:R:L158	3.59	1	Yes	No	0	5	0	1
L:L:?1	R:R:H161	4.16	1	Yes	No	0	7	0	1
L:L:?1	R:R:L162	7.17	1	Yes	No	0	4	0	1
L:L:?1	R:R:S179	3.89	1	Yes	No	0	4	0	1
L:L:?1	R:R:F180	17.35	1	Yes	No	0	3	0	1
L:L:?1	R:R:H189	12.49	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:E196	6.01	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F277	3.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:L280	5.38	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	5.31	1	Yes	No	0	7	0	1
R:R:I26	R:R:L30	7.14	1	No	No	5	5	2	2
R:R:I26	R:R:Y87	4.84	1	No	No	5	6	2	1
R:R:L30	R:R:Y87	7.03	1	No	No	5	6	2	1
R:R:E37	R:R:Y284	7.86	0	Yes	No	7	7	2	1
R:R:C79	R:R:M103	3.24	3	Yes	Yes	6	5	2	2
R:R:C79	R:R:L107	3.17	3	Yes	No	6	6	2	1
R:R:L104	R:R:M103	7.07	0	No	Yes	5	5	1	2
R:R:F193	R:R:R111	4.28	0	No	No	6	8	2	1
R:R:Q112	R:R:T155	8.5	1	No	No	7	7	1	2
R:R:E196	R:R:Q112	17.84	1	Yes	No	5	7	1	1
R:R:I154	R:R:L158	5.71	0	No	No	5	5	2	1
R:R:H161	R:R:L162	9	1	No	No	7	4	1	1
R:R:H161	R:R:W188	12.7	1	No	No	7	5	1	2
R:R:F180	R:R:H189	4.53	1	No	Yes	3	5	1	1
R:R:F180	R:R:F276	7.5	1	No	Yes	3	4	1	2
R:R:H189	R:R:Q187	9.89	1	Yes	Yes	5	2	1	2
R:R:E190	R:R:Q187	5.1	1	Yes	Yes	4	2	2	2
R:R:E190	R:R:H189	12.31	1	Yes	Yes	4	5	2	1
R:R:E196	R:R:M192	10.83	1	Yes	No	5	5	1	2
R:R:E196	R:R:F193	4.66	1	Yes	No	5	6	1	2
R:R:D273	R:R:F277	9.55	0	No	No	4	5	2	1
R:R:F276	R:R:F277	4.29	0	Yes	No	4	5	2	1
R:R:F276	R:R:L280	4.87	0	Yes	No	4	5	2	1
L:L:?1	R:R:S178	1.94	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8J6I_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	272
Number of Links	303
Number of Hubs	36
Number of Links mediated by Hubs	140
Number of Communities	8
Number of Nodes involved in Communities	63
Number of Links involved in Communities	80

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	54996
Length Of Smallest Path	3
Average Path Length	15.821
Length of Longest Path	38
Minimum Path Strength	1.34
Average Path Strength	5.88722
Maximum Path Strength	15.41
Minimum Path Correlation	0.7
Average Path Correlation	0.922479
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	44.4631
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.0884
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FI7
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FI7
Name	2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid
Synonyms
Identifier
Formula	C19 H22 N4 O5
Molecular Weight	386.402
SMILES
PubChem	135416394
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	0
Total Bonds	52
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8J6I_nogp_Chain_R I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	To be published
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	To be published
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	To be published
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	To be published

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