psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	2.69	Yes	Yes	1	0	6
2	L:L:?1	R:R:L107	9.86	Yes	No	0	0	6
3	L:L:?1	R:R:A108	6.12	Yes	No	0	0	4
4	L:L:?1	R:R:R111	7.08	Yes	No	1	0	8
5	L:L:?1	R:R:Q112	6.9	Yes	Yes	0	0	7
6	L:L:?1	R:R:T159	2.86	Yes	No	1	0	7
7	L:L:?1	R:R:L162	5.38	Yes	No	0	0	4
8	L:L:?1	R:R:S178	4.86	Yes	No	0	0	4
9	L:L:?1	R:R:S179	5.83	Yes	No	1	0	4
10	L:L:?1	R:R:F180	18.93	Yes	Yes	1	0	3
11	L:L:?1	R:R:H189	16.65	Yes	Yes	1	0	5
12	L:L:?1	R:R:M192	5.49	Yes	No	0	0	5
13	L:L:?1	R:R:L280	4.48	Yes	No	0	0	5
14	L:L:?1	R:R:Y284	6.07	Yes	Yes	1	0	7
15	R:R:F10	R:R:F21	3.22	No	Yes	0	7	2
16	R:R:L11	R:R:N17	8.24	No	No	0	8	5
17	R:R:E12	R:R:V20	2.85	No	No	0	5	2
18	R:R:E12	R:R:N171	13.15	No	No	0	5	1
19	R:R:C18	R:R:D14	3.11	No	No	0	9	5
20	R:R:D14	R:R:I169	9.8	No	Yes	0	5	1
21	R:R:K16	R:R:T185	9.01	No	No	1	4	2
22	R:R:K16	R:R:Q187	10.85	No	No	1	4	2
23	R:R:C18	R:R:C183	7.28	No	No	0	9	1
24	R:R:C19	R:R:F21	2.79	Yes	Yes	1	4	2
25	R:R:C19	R:R:I182	3.27	Yes	Yes	1	4	3
26	R:R:C19	R:R:C266	7.28	Yes	Yes	1	4	7
27	R:R:C19	R:R:Y269	2.69	Yes	Yes	1	4	2
28	R:R:L176	R:R:V20	2.98	No	No	0	4	2
29	R:R:S181	R:R:V20	3.23	No	No	0	4	2
30	R:R:C266	R:R:F21	2.79	Yes	Yes	1	7	2
31	R:R:F21	R:R:Y269	6.19	Yes	Yes	1	2	2
32	R:R:D273	R:R:F21	8.36	No	Yes	0	4	2
33	R:R:R22	R:R:W91	6	No	No	0	3	4
34	R:R:D23	R:R:L274	2.71	No	No	0	4	1
35	R:R:D24	R:R:V27	4.38	No	No	0	4	3
36	R:R:F25	R:R:K28	11.17	No	No	0	6	3
37	R:R:I26	R:R:Y87	4.84	No	Yes	0	5	6
38	R:R:I26	R:R:L274	2.85	No	No	0	5	1
39	R:R:R90	R:R:V27	2.62	No	No	0	4	3
40	R:R:P31	R:R:P32	5.84	Yes	No	0	6	5
41	R:R:P31	R:R:V88	3.53	Yes	No	0	6	3
42	R:R:L34	R:R:V33	2.98	Yes	No	0	8	5
43	R:R:L34	R:R:L80	2.77	Yes	No	0	8	8
44	R:R:L34	R:R:L83	2.77	Yes	Yes	1	8	6
45	R:R:L34	R:R:M84	2.83	Yes	No	0	8	7
46	R:R:L34	R:R:Y284	5.86	Yes	Yes	1	8	7
47	R:R:E37	R:R:Y284	4.49	No	Yes	0	7	7
48	R:R:F38	R:R:I77	2.51	No	Yes	0	7	6
49	R:R:F38	R:R:L80	9.74	No	No	0	7	8
50	R:R:F38	R:R:P81	11.56	No	No	0	7	8
51	R:R:F40	R:R:I39	5.02	No	No	0	6	5
52	R:R:F40	R:R:M288	4.98	No	No	0	6	8
53	R:R:G41	R:R:I77	3.53	No	Yes	0	8	6
54	R:R:F74	R:R:L42	3.65	Yes	No	0	7	7
55	R:R:I77	R:R:L42	2.85	Yes	No	0	6	7
56	R:R:L43	R:R:L47	2.77	No	No	0	4	6
57	R:R:G44	R:R:P291	4.06	No	No	0	7	9
58	R:R:D73	R:R:N45	13.46	Yes	No	0	9	9
59	R:R:N45	R:R:P291	9.77	No	No	0	9	9
60	R:R:A48	R:R:Y295	5.34	No	No	0	9	7
61	R:R:F67	R:R:L49	3.65	Yes	Yes	2	6	7
62	R:R:A70	R:R:L49	3.15	No	Yes	0	8	7
63	R:R:L49	R:R:V71	2.98	Yes	No	2	7	6
64	R:R:F74	R:R:L49	3.65	Yes	Yes	0	7	7
65	R:R:F54	R:R:W50	3.01	No	No	0	4	4
66	R:R:F52	R:R:I51	3.77	Yes	No	0	7	7
67	R:R:F296	R:R:I51	3.77	No	No	0	8	7
68	R:R:F52	R:R:L56	4.87	Yes	No	0	7	5
69	R:R:F52	R:R:F67	10.72	Yes	Yes	0	7	6
70	R:R:F52	R:R:Y295	10.32	Yes	No	0	7	7
71	R:R:C53	R:R:F67	2.79	No	Yes	0	4	6
72	R:R:L56	R:R:S58	3	No	No	0	5	6
73	R:R:L56	R:R:R63	4.86	No	No	0	5	7
74	R:R:K60	R:R:S58	9.18	No	No	0	7	6
75	R:R:F65	R:R:S61	2.64	Yes	No	2	7	6
76	R:R:I139	R:R:S61	6.19	No	No	0	7	6
77	R:R:A144	R:R:S61	3.42	No	No	2	7	6
78	R:R:D124	R:R:S62	7.36	No	No	6	8	8
79	R:R:R128	R:R:S62	5.27	No	No	6	8	8
80	R:R:A144	R:R:I64	3.25	No	No	0	7	7
81	R:R:F65	R:R:V120	9.18	Yes	No	0	7	7
82	R:R:A144	R:R:F65	2.77	No	Yes	2	7	7
83	R:R:F65	R:R:I147	5.02	Yes	No	0	7	5
84	R:R:F65	R:R:S148	2.64	Yes	No	2	7	8
85	R:R:L66	R:R:V121	7.45	No	No	0	8	9
86	R:R:F67	R:R:V71	7.87	Yes	No	2	6	6
87	R:R:F117	R:R:N68	15.71	Yes	No	2	8	9
88	R:R:N68	R:R:S148	8.94	No	No	2	9	8
89	R:R:N68	R:R:W152	5.65	No	Yes	2	9	9
90	R:R:F117	R:R:L69	3.65	Yes	No	0	8	9
91	R:R:A70	R:R:Y295	4	No	No	0	8	7
92	R:R:V71	R:R:W152	2.45	No	Yes	2	6	9
93	R:R:A72	R:R:W152	3.89	No	Yes	0	8	9
94	R:R:D73	R:R:S114	5.89	Yes	No	0	9	9
95	R:R:D73	R:R:S287	2.94	Yes	No	0	9	8
96	R:R:D290	R:R:D73	2.66	No	Yes	0	9	9
97	R:R:F74	R:R:I78	2.51	Yes	No	0	7	6
98	R:R:L75	R:R:M106	2.83	No	Yes	1	6	5
99	R:R:L75	R:R:N110	13.73	No	Yes	1	6	9
100	R:R:L107	R:R:L76	2.77	No	No	0	6	7
101	R:R:L76	R:R:N110	4.12	No	Yes	0	7	9
102	R:R:I77	R:R:S287	3.1	Yes	No	0	6	8
103	R:R:C79	R:R:M103	4.86	No	Yes	0	6	5
104	R:R:C79	R:R:L107	6.35	No	No	0	6	6
105	R:R:F82	R:R:M103	4.98	No	Yes	0	6	5
106	R:R:L83	R:R:N86	2.75	Yes	No	0	6	5
107	R:R:L83	R:R:Y87	9.38	Yes	Yes	0	6	6
108	R:R:L83	R:R:M103	2.83	Yes	Yes	0	6	5
109	R:R:L83	R:R:Y284	3.52	Yes	Yes	1	6	7
110	R:R:D85	R:R:R89	16.68	No	No	8	4	4
111	R:R:D85	R:R:K94	4.15	No	No	8	4	3
112	R:R:N86	R:R:W91	4.52	No	No	0	5	4
113	R:R:W91	R:R:Y87	10.61	No	Yes	0	4	6
114	R:R:F277	R:R:Y87	4.13	No	Yes	0	5	6
115	R:R:D92	R:R:R89	10.72	No	No	0	4	4
116	R:R:K94	R:R:R89	7.43	No	No	8	3	4
117	R:R:P99	R:R:W93	2.7	No	Yes	0	5	9
118	R:R:C100	R:R:W93	9.14	Yes	Yes	5	9	9
119	R:R:P168	R:R:W93	2.7	No	Yes	5	4	9
120	R:R:C177	R:R:W93	16.98	No	Yes	5	9	9
121	R:R:F95	R:R:K94	8.69	No	No	0	7	3
122	R:R:F95	R:R:P99	2.89	No	No	0	7	5
123	R:R:D97	R:R:R101	8.34	No	No	0	3	6
124	R:R:D97	R:R:K166	5.53	No	No	0	3	4
125	R:R:D97	R:R:P168	12.88	No	No	0	3	4
126	R:R:I98	R:R:P99	3.39	No	No	0	2	5
127	R:R:I98	R:R:R101	3.76	No	No	0	2	6
128	R:R:C100	R:R:M167	6.48	Yes	No	0	9	3
129	R:R:C100	R:R:P168	9.41	Yes	No	5	9	4
130	R:R:C100	R:R:C177	7.28	Yes	No	5	9	9
131	R:R:L102	R:R:M106	2.83	No	Yes	0	5	5
132	R:R:L104	R:R:M167	4.24	No	No	0	5	3
133	R:R:C177	R:R:L104	4.76	No	No	0	9	5
134	R:R:F105	R:R:M106	2.49	Yes	Yes	1	6	5
135	R:R:F105	R:R:M109	6.22	Yes	Yes	1	6	5
136	R:R:F105	R:R:T159	6.49	Yes	No	1	6	7
137	R:R:F105	R:R:L163	8.53	Yes	No	0	6	5
138	R:R:M106	R:R:M109	2.89	Yes	Yes	1	5	5
139	R:R:M106	R:R:N110	7.01	Yes	Yes	1	5	9
140	R:R:M109	R:R:N110	4.21	Yes	Yes	1	5	9
141	R:R:M109	R:R:T155	4.52	Yes	No	0	5	7
142	R:R:I156	R:R:M109	2.92	No	Yes	0	4	5
143	R:R:M109	R:R:T159	7.53	Yes	No	1	5	7
144	R:R:R111	R:R:T283	7.76	No	No	0	8	8
145	R:R:R111	R:R:Y284	5.14	No	Yes	1	8	7
146	R:R:Q112	R:R:T155	2.83	Yes	No	0	7	7
147	R:R:L158	R:R:Q112	2.66	No	Yes	0	5	7
148	R:R:E196	R:R:Q112	5.1	No	Yes	0	5	7
149	R:R:E196	R:R:I115	4.1	No	No	0	5	8
150	R:R:I115	R:R:P200	3.39	No	Yes	0	8	9
151	R:R:I116	R:R:L151	2.85	No	No	0	5	7
152	R:R:F117	R:R:S148	3.96	Yes	No	2	8	8
153	R:R:F117	R:R:W152	7.02	Yes	Yes	2	8	9
154	R:R:P200	R:R:T119	6.99	Yes	No	0	9	7
155	R:R:I203	R:R:T119	4.56	No	No	0	7	7
156	R:R:R125	R:R:V121	3.92	No	No	7	9	9
157	R:R:V121	R:R:Y294	3.79	No	Yes	7	9	9
158	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
159	R:R:D124	R:R:R128	9.53	No	No	6	8	8
160	R:R:R125	R:R:Y294	4.12	No	Yes	7	9	9
161	R:R:F127	R:R:Y126	3.09	Yes	Yes	0	5	7
162	R:R:V130	R:R:Y126	12.62	Yes	Yes	4	8	7
163	R:R:H131	R:R:Y126	6.53	No	Yes	4	7	7
164	R:R:F206	R:R:Y126	3.09	No	Yes	4	4	7
165	R:R:C207	R:R:Y126	5.38	No	Yes	0	8	7
166	R:R:R210	R:R:Y126	11.32	No	Yes	4	4	7
167	R:R:F127	R:R:H134	9.05	Yes	No	0	5	4
168	R:R:N137	R:R:R128	6.03	No	No	0	4	8
169	R:R:H131	R:R:V130	4.15	No	Yes	4	7	8
170	R:R:R210	R:R:V130	3.92	No	Yes	4	4	8
171	R:R:H134	R:R:L136	2.57	No	No	0	4	4
172	R:R:S140	R:R:T143	3.2	No	No	0	6	3
173	R:R:I154	R:R:L158	2.85	No	No	0	5	5
174	R:R:G157	R:R:I156	3.53	No	No	0	5	4
175	R:R:H161	R:R:L162	6.43	No	No	0	7	4
176	R:R:H161	R:R:W188	8.46	No	No	0	7	5
177	R:R:K164	R:R:K165	4.31	No	No	0	4	4
178	R:R:I169	R:R:N171	2.83	Yes	No	0	1	1
179	R:R:I169	R:R:L176	4.28	Yes	No	0	1	4
180	R:R:N175	R:R:Q170	5.28	No	No	0	4	1
181	R:R:H189	R:R:S179	5.58	Yes	No	1	5	4
182	R:R:E190	R:R:F180	7	Yes	Yes	1	4	3
183	R:R:F180	R:R:F193	3.22	Yes	No	0	3	6
184	R:R:F180	R:R:R251	5.34	Yes	Yes	1	3	5
185	R:R:F180	R:R:F276	4.29	Yes	No	1	3	4
186	R:R:I182	R:R:I254	2.94	Yes	Yes	1	3	4
187	R:R:I182	R:R:L258	4.28	Yes	No	1	3	3
188	R:R:I182	R:R:Y269	4.84	Yes	Yes	1	3	2
189	R:R:D273	R:R:I182	9.8	No	Yes	0	4	3
190	R:R:H184	R:R:T263	4.11	No	No	0	3	3
191	R:R:Q187	R:R:T185	4.25	No	No	1	2	2
192	R:R:F186	R:R:W188	3.01	No	No	0	4	5
193	R:R:H189	R:R:Q187	9.89	Yes	No	1	5	2
194	R:R:M192	R:R:W188	4.65	No	No	0	5	5
195	R:R:E190	R:R:H189	2.46	Yes	Yes	1	4	5
196	R:R:E190	R:R:R251	11.63	Yes	Yes	1	4	5
197	R:R:E190	R:R:F255	9.33	Yes	Yes	1	4	5
198	R:R:E196	R:R:F193	5.83	No	No	0	5	6
199	R:R:F193	R:R:S247	2.64	No	No	0	6	6
200	R:R:F197	R:R:F198	7.5	Yes	No	3	8	5
201	R:R:F197	R:R:F240	5.36	Yes	Yes	3	8	9
202	R:R:F197	R:R:F244	6.43	Yes	Yes	3	8	8
203	R:R:F197	R:R:L245	4.87	Yes	No	0	8	6
204	R:R:F197	R:R:V248	3.93	Yes	No	3	8	8
205	R:R:F198	R:R:V248	2.62	No	No	3	5	8
206	R:R:L199	R:R:P200	4.93	No	Yes	0	4	9
207	R:R:I203	R:R:L199	2.85	No	No	0	7	4
208	R:R:F240	R:R:P200	2.89	Yes	Yes	0	9	9
209	R:R:L201	R:R:L205	5.54	Yes	No	0	7	4
210	R:R:F240	R:R:L201	7.31	Yes	Yes	0	9	7
211	R:R:L201	R:R:V241	2.98	Yes	No	0	7	5
212	R:R:F206	R:R:R210	6.41	No	No	4	4	4
213	R:R:I233	R:R:S208	3.1	No	No	0	7	8
214	R:R:I212	R:R:R216	5.01	Yes	No	0	5	4
215	R:R:I212	R:R:I230	7.36	Yes	No	0	5	6
216	R:R:I212	R:R:M234	2.92	Yes	No	0	5	4
217	R:R:Q217	R:R:W213	9.86	No	No	0	5	3
218	R:R:L215	R:R:M220	2.83	Yes	No	9	8	3
219	R:R:I226	R:R:L215	7.14	Yes	Yes	9	6	8
220	R:R:I230	R:R:L215	2.85	No	Yes	0	6	8
221	R:R:D221	R:R:R216	5.96	No	No	0	3	4
222	R:R:M220	R:R:R218	7.44	No	No	0	3	5
223	R:R:Q219	R:R:R222	10.51	No	No	0	3	3
224	R:R:I226	R:R:M220	2.92	Yes	No	9	6	3
225	R:R:D221	R:R:K227	6.91	No	No	0	3	4
226	R:R:H223	R:R:K225	14.41	No	No	0	4	5
227	R:R:H223	R:R:I226	2.65	No	Yes	0	4	6
228	R:R:I226	R:R:K227	4.36	Yes	No	0	6	4
229	R:R:F232	R:R:R228	6.41	Yes	No	0	7	7
230	R:R:F232	R:R:T231	3.89	Yes	No	0	7	6
231	R:R:F232	R:R:S297	5.28	Yes	No	0	7	6
232	R:R:V236	R:R:V293	3.21	No	No	0	8	8
233	R:R:V236	R:R:Y294	6.31	No	Yes	0	8	9
234	R:R:L289	R:R:V239	4.47	No	No	0	7	7
235	R:R:F240	R:R:F244	3.22	Yes	Yes	3	9	8
236	R:R:L245	R:R:V241	4.47	No	No	0	6	5
237	R:R:C243	R:R:F244	2.79	No	Yes	3	8	8
238	R:R:C243	R:R:M285	3.24	No	No	0	8	5
239	R:R:C243	R:R:N286	3.15	No	No	3	8	9
240	R:R:F244	R:R:T283	9.08	Yes	No	0	8	8
241	R:R:F244	R:R:N286	8.46	Yes	No	3	8	9
242	R:R:L245	R:R:V249	2.98	No	No	0	6	6
243	R:R:P246	R:R:T279	3.5	No	No	0	9	7
244	R:R:F282	R:R:P246	5.78	No	No	0	7	9
245	R:R:S247	R:R:T279	3.2	No	No	0	6	7
246	R:R:T279	R:R:V250	6.35	No	No	0	7	5
247	R:R:I254	R:R:R251	6.26	Yes	Yes	1	4	5
248	R:R:F255	R:R:R251	10.69	Yes	Yes	1	5	5
249	R:R:F276	R:R:R251	21.38	No	Yes	1	4	5
250	R:R:R253	R:R:W256	5	No	No	0	5	4
251	R:R:L257	R:R:R253	9.72	Yes	No	0	3	5
252	R:R:F255	R:R:I254	3.77	Yes	Yes	1	5	4
253	R:R:I254	R:R:V272	3.07	Yes	No	0	4	4
254	R:R:T260	R:R:W256	8.49	No	No	0	1	4
255	R:R:L257	R:R:T260	2.95	Yes	No	0	3	1
256	R:R:L257	R:R:V268	4.47	Yes	No	0	3	1
257	R:R:L257	R:R:V272	2.98	Yes	No	0	3	4
258	R:R:L258	R:R:Y269	8.21	No	Yes	1	3	2
259	R:R:N265	R:R:Q264	2.64	No	No	0	5	3
260	R:R:C266	R:R:Y269	5.38	Yes	Yes	1	7	2
261	R:R:E267	R:R:R270	10.47	No	No	0	2	1
262	R:R:V268	R:R:Y269	3.79	No	Yes	0	1	2
263	R:R:V272	R:R:Y269	2.52	No	Yes	0	4	2
264	R:R:F282	R:R:S281	2.64	No	No	0	7	6
265	R:R:M285	R:R:M288	5.78	No	No	0	5	8
266	R:R:L289	R:R:M285	2.83	No	No	0	7	5
267	R:R:D290	R:R:N286	10.77	No	No	0	9	9
268	R:R:S297	R:R:V292	3.23	No	No	0	6	6
269	R:R:F240	R:R:L118	2.44	Yes	No	0	9	9
270	R:R:F127	R:R:N137	2.42	Yes	No	0	5	4
271	R:R:I64	R:R:W59	2.35	No	No	0	7	6
272	R:R:L118	R:R:Y294	2.34	No	Yes	0	9	9
273	R:R:M103	R:R:W93	2.33	Yes	Yes	0	5	9
274	R:R:F54	R:R:H55	2.26	No	No	0	4	5
275	R:R:F21	R:R:R270	2.14	Yes	No	0	2	1
276	R:R:G172	R:R:G173	2.11	No	No	0	3	4
277	R:R:A72	R:R:G113	1.95	No	No	0	8	7
278	R:R:G262	R:R:S261	1.86	No	No	0	4	3
279	R:R:G157	R:R:V160	1.84	No	No	0	5	4
280	R:R:G35	R:R:M84	1.75	No	No	0	5	7
281	R:R:G44	R:R:L43	1.71	No	No	0	7	4
282	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
283	R:R:G172	R:R:N171	1.7	No	No	0	3	1
284	R:R:A275	R:R:V250	1.7	No	No	0	5	5
285	R:R:C19	R:R:T263	1.69	Yes	No	1	4	3
286	R:R:C266	R:R:T263	1.69	Yes	No	1	7	3
287	R:R:M84	R:R:P31	1.68	No	Yes	0	7	6
288	R:R:L30	R:R:P31	1.64	No	Yes	0	5	6
289	R:R:C207	R:R:I203	1.64	No	No	0	8	7
290	R:R:S178	R:R:S181	1.63	No	No	0	4	4
291	R:R:S214	R:R:V130	1.62	No	Yes	0	5	8
292	R:R:A237	R:R:I204	1.62	No	No	0	7	8
293	R:R:V29	R:R:V33	1.6	No	No	0	5	5
294	R:R:V235	R:R:V293	1.6	No	No	0	5	8
295	R:R:S261	R:R:T260	1.6	No	No	0	3	1
296	R:R:I204	R:R:S208	1.55	No	No	0	8	8
297	R:R:I278	R:R:S281	1.55	No	No	0	6	6
298	R:R:I252	R:R:V248	1.54	No	No	0	6	8
299	R:R:H131	R:R:P132	1.53	No	No	0	7	8
300	R:R:K28	R:R:V27	1.52	No	No	0	3	3
301	R:R:I204	R:R:T119	1.52	No	No	0	8	7
302	R:R:I139	R:R:T143	1.52	No	No	0	7	3
303	R:R:F74	R:R:G46	1.51	Yes	No	0	7	4
304	R:R:L151	R:R:V120	1.49	No	No	0	7	7
305	R:R:L215	R:R:V129	1.49	Yes	No	0	8	8
306	R:R:I211	R:R:I233	1.47	No	No	0	8	7
307	R:R:I212	R:R:I233	1.47	Yes	No	0	5	7
308	R:R:A224	R:R:H223	1.46	No	No	0	3	4
309	R:R:I169	R:R:K15	1.45	Yes	No	0	1	3
310	R:R:K165	R:R:M167	1.44	No	No	0	4	3
311	R:R:I39	R:R:L36	1.43	No	No	0	5	4
312	R:R:I147	R:R:L150	1.43	No	No	0	5	4
313	R:R:I64	R:R:N141	1.42	No	No	0	7	2
314	R:R:G96	R:R:W93	1.41	No	Yes	0	7	9
315	R:R:C53	R:R:F54	1.4	No	No	0	4	4
316	R:R:A191	R:R:F186	1.39	No	No	0	3	4
317	R:R:F232	R:R:V235	1.31	Yes	No	0	7	5
318	R:R:F255	R:R:L194	1.22	Yes	No	0	5	4
319	R:R:D221	R:R:R222	1.19	No	No	0	3	3
320	R:R:N175	R:R:W93	1.13	No	Yes	0	4	9
321	R:R:R22	R:R:R90	1.07	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.37143	14	1	0
2	R:R:C19	3.544	5	1	4
3	R:R:F21	4.24833	6	1	2
4	R:R:P31	3.1725	4	0	6
5	R:R:L34	3.442	5	1	8
6	R:R:L49	3.3575	4	2	7
7	R:R:F52	7.42	4	0	7
8	R:R:F65	4.45	5	2	7
9	R:R:F67	6.2575	4	2	6
10	R:R:D73	6.2375	4	0	9
11	R:R:F74	2.83	4	0	7
12	R:R:I77	2.9975	4	0	6
13	R:R:L83	3.99	6	1	6
14	R:R:Y87	7.24	4	0	6
15	R:R:W93	5.19857	7	5	9
16	R:R:C100	8.0775	4	5	9
17	R:R:M103	3.75	4	0	5
18	R:R:F105	5.9325	4	1	6
19	R:R:M106	3.61	5	1	5
20	R:R:M109	4.715	6	1	5
21	R:R:N110	7.2675	4	1	9
22	R:R:Q112	4.3725	4	0	7
23	R:R:F117	7.585	4	2	8
24	R:R:Y126	7.005	6	4	7
25	R:R:F127	4.295	4	0	5
26	R:R:V130	5.5775	4	4	8
27	R:R:W152	4.7525	4	2	9
28	R:R:I169	4.59	4	0	1
29	R:R:F180	7.756	5	1	3
30	R:R:I182	5.026	5	1	3
31	R:R:H189	8.645	4	1	5
32	R:R:E190	7.605	4	1	4
33	R:R:F197	5.618	5	3	8
34	R:R:P200	4.55	4	0	9
35	R:R:L201	4.385	4	0	7
36	R:R:I212	4.19	4	0	5
37	R:R:L215	3.5775	4	9	8
38	R:R:I226	4.2675	4	9	6
39	R:R:F232	4.2225	4	0	7
40	R:R:F240	4.244	5	3	9
41	R:R:F244	5.996	5	3	8
42	R:R:R251	11.06	5	1	5
43	R:R:I254	4.01	4	1	4
44	R:R:F255	6.2525	4	1	5
45	R:R:L257	5.03	4	0	3
46	R:R:C266	4.285	4	1	7
47	R:R:Y269	4.80286	7	1	2
48	R:R:Y284	5.016	5	1	7
49	R:R:Y294	4.14	4	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F180	69.9859	18.93	Yes	Yes	1	0	3
2	R:R:F180	R:R:R251	69.9677	5.34	Yes	Yes	1	3	5
3	R:R:I254	R:R:R251	66.4211	6.26	Yes	Yes	1	4	5
4	R:R:I182	R:R:I254	38.1258	2.94	Yes	Yes	1	3	4
5	R:R:C19	R:R:I182	14.1727	3.27	Yes	Yes	1	4	3
6	R:R:I182	R:R:Y269	12.2175	4.84	Yes	Yes	1	3	2
7	R:R:F21	R:R:Y269	14.2545	6.19	Yes	Yes	1	2	2
8	R:R:I254	R:R:V272	28.159	3.07	Yes	No	0	4	4
9	R:R:V272	R:R:Y269	12.7586	2.52	No	Yes	0	4	2
10	L:L:?1	R:R:S178	22.8436	4.86	Yes	No	0	0	4
11	R:R:S178	R:R:S181	21.2795	1.63	No	No	0	4	4
12	R:R:S181	R:R:V20	19.6608	3.23	No	No	0	4	2
13	R:R:L176	R:R:V20	10.7852	2.98	No	No	0	4	2
14	L:L:?1	R:R:L83	79.9982	2.69	Yes	Yes	1	0	6
15	R:R:L83	R:R:N86	12.8223	2.75	Yes	No	0	6	5
16	R:R:N86	R:R:W91	11.2536	4.52	No	No	0	5	4
17	R:R:R22	R:R:W91	19.3925	6	No	No	0	3	4
18	R:R:L83	R:R:Y87	19.0515	9.38	Yes	Yes	0	6	6
19	R:R:W91	R:R:Y87	11.3809	10.61	No	Yes	0	4	6
20	R:R:R22	R:R:R90	16.1824	1.07	No	No	0	3	4
21	R:R:R90	R:R:V27	12.9632	2.62	No	No	0	4	3
22	R:R:L34	R:R:L83	55.4949	2.77	Yes	Yes	1	8	6
23	R:R:L34	R:R:M84	15.1639	2.83	Yes	No	0	8	7
24	R:R:M84	R:R:P31	10.1441	1.68	No	Yes	0	7	6
25	L:L:?1	R:R:Y284	40.5765	6.07	Yes	Yes	1	0	7
26	R:R:L34	R:R:Y284	45.4326	5.86	Yes	Yes	1	8	7
27	R:R:L34	R:R:L80	84.1131	2.77	Yes	No	0	8	8
28	R:R:F38	R:R:L80	82.208	9.74	No	No	0	7	8
29	R:R:F38	R:R:I77	79.2889	2.51	No	Yes	0	7	6
30	L:L:?1	R:R:R111	28.7319	7.08	Yes	No	1	0	8
31	R:R:R111	R:R:T283	42.3044	7.76	No	No	0	8	8
32	R:R:F244	R:R:T283	41.7906	9.08	Yes	No	0	8	8
33	R:R:C243	R:R:F244	11.2354	2.79	No	Yes	3	8	8
34	R:R:C243	R:R:M285	12.122	3.24	No	No	0	8	5
35	R:R:I77	R:R:L42	100	2.85	Yes	No	0	6	7
36	R:R:F74	R:R:L42	98.4813	3.65	Yes	No	0	7	7
37	R:R:F244	R:R:N286	33.6016	8.46	Yes	No	3	8	9
38	R:R:D290	R:R:N286	35.0657	10.77	No	No	0	9	9
39	R:R:D290	R:R:D73	33.9835	2.66	No	Yes	0	9	9
40	R:R:F74	R:R:L49	93.8662	3.65	Yes	Yes	0	7	7
41	R:R:F67	R:R:L49	21.3795	3.65	Yes	Yes	2	6	7
42	R:R:L49	R:R:V71	66.412	2.98	Yes	No	2	7	6
43	R:R:F52	R:R:F67	14.0363	10.72	Yes	Yes	0	7	6
44	R:R:V71	R:R:W152	67.0031	2.45	No	Yes	2	6	9
45	R:R:N68	R:R:W152	29.8686	5.65	No	Yes	2	9	9
46	R:R:N68	R:R:S148	28.0453	8.94	No	No	2	9	8
47	R:R:F65	R:R:S148	52.6167	2.64	Yes	No	2	7	8
48	R:R:F117	R:R:W152	31.9465	7.02	Yes	Yes	2	8	9
49	R:R:F117	R:R:S148	28.2999	3.96	Yes	No	2	8	8
50	R:R:F65	R:R:S61	14.8866	2.64	Yes	No	2	7	6
51	R:R:I139	R:R:S61	11.1263	6.19	No	No	0	7	6
52	R:R:A144	R:R:F65	15.3094	2.77	No	Yes	2	7	7
53	L:L:?1	R:R:Q112	34.6974	6.9	Yes	Yes	0	0	7
54	R:R:E196	R:R:Q112	35.0566	5.1	No	Yes	0	5	7
55	R:R:E196	R:R:I115	54.2673	4.1	No	No	0	5	8
56	R:R:I115	R:R:P200	53.658	3.39	No	Yes	0	8	9
57	R:R:P200	R:R:T119	52.6668	6.99	Yes	No	0	9	7
58	R:R:I203	R:R:T119	24.6488	4.56	No	No	0	7	7
59	R:R:C207	R:R:I203	44.737	1.64	No	No	0	8	7
60	R:R:C207	R:R:Y126	41.9861	5.38	No	Yes	0	8	7
61	R:R:F127	R:R:Y126	22.6572	3.09	Yes	Yes	0	5	7
62	R:R:F127	R:R:N137	11.3081	2.42	Yes	No	0	5	4
63	R:R:L199	R:R:P200	24.3032	4.93	No	Yes	0	4	9
64	R:R:I203	R:R:L199	23.0255	2.85	No	No	0	7	4
65	R:R:A144	R:R:I64	11.5491	3.25	No	No	0	7	7
66	R:R:F65	R:R:V120	11.34	9.18	Yes	No	0	7	7
67	R:R:F240	R:R:F244	49.343	3.22	Yes	Yes	3	9	8
68	R:R:F240	R:R:L118	24.6669	2.44	Yes	No	0	9	9
69	R:R:L118	R:R:Y294	22.7845	2.34	No	Yes	0	9	9
70	R:R:I77	R:R:S287	31.9011	3.1	Yes	No	0	6	8
71	L:L:?1	R:R:T159	22.4481	2.86	Yes	No	1	0	7
72	R:R:M109	R:R:T159	12.9314	7.53	Yes	No	1	5	7
73	R:R:L83	R:R:M103	37.1618	2.83	Yes	Yes	0	6	5
74	R:R:M103	R:R:W93	34.6519	2.33	Yes	Yes	0	5	9
75	R:R:P99	R:R:W93	13.086	2.7	No	Yes	0	5	9
76	R:R:F180	R:R:F193	29.0456	3.22	Yes	No	0	3	6
77	R:R:F193	R:R:S247	15.4549	2.64	No	No	0	6	6
78	R:R:I204	R:R:T119	30.2687	1.52	No	No	0	8	7
79	R:R:I204	R:R:S208	27.5497	1.55	No	No	0	8	8
80	R:R:I233	R:R:S208	26.1765	3.1	No	No	0	7	8
81	R:R:I212	R:R:I233	23.3893	1.47	Yes	No	0	5	7
82	R:R:I212	R:R:I230	13.2224	7.36	Yes	No	0	5	6
83	R:R:I230	R:R:L215	11.7674	2.85	No	Yes	0	6	8
84	R:R:V236	R:R:Y294	15.5459	6.31	No	Yes	0	8	9
85	R:R:V236	R:R:V293	13.6498	3.21	No	No	0	8	8
86	R:R:V235	R:R:V293	11.7219	1.6	No	No	0	5	8
87	R:R:S247	R:R:T279	13.5543	3.2	No	No	0	6	7
88	R:R:L257	R:R:V272	14.6865	2.98	Yes	No	0	3	4
89	R:R:F21	R:R:R270	14.3818	2.14	Yes	No	0	2	1
90	R:R:R111	R:R:Y284	14.3546	5.14	No	Yes	1	8	7
91	R:R:D73	R:R:S287	30.8325	2.94	Yes	No	0	9	8
92	R:R:F240	R:R:P200	38.8806	2.89	Yes	Yes	0	9	9
93	R:R:E196	R:R:F193	21.1567	5.83	No	No	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	2.69	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L107	9.86	1	Yes	No	0	6	0	1
L:L:?1	R:R:A108	6.12	1	Yes	No	0	4	0	1
L:L:?1	R:R:R111	7.08	1	Yes	No	0	8	0	1
L:L:?1	R:R:Q112	6.9	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T159	2.86	1	Yes	No	0	7	0	1
L:L:?1	R:R:L162	5.38	1	Yes	No	0	4	0	1
L:L:?1	R:R:S178	4.86	1	Yes	No	0	4	0	1
L:L:?1	R:R:S179	5.83	1	Yes	No	0	4	0	1
L:L:?1	R:R:F180	18.93	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:H189	16.65	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M192	5.49	1	Yes	No	0	5	0	1
L:L:?1	R:R:L280	4.48	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	6.07	1	Yes	Yes	0	7	0	1
R:R:L34	R:R:L83	2.77	1	Yes	Yes	8	6	2	1
R:R:L34	R:R:Y284	5.86	1	Yes	Yes	8	7	2	1
R:R:E37	R:R:Y284	4.49	0	No	Yes	7	7	2	1
R:R:L107	R:R:L76	2.77	0	No	No	6	7	1	2
R:R:C79	R:R:M103	4.86	0	No	Yes	6	5	2	2
R:R:C79	R:R:L107	6.35	0	No	No	6	6	2	1
R:R:L83	R:R:N86	2.75	1	Yes	No	6	5	1	2
R:R:L83	R:R:Y87	9.38	1	Yes	Yes	6	6	1	2
R:R:L83	R:R:M103	2.83	1	Yes	Yes	6	5	1	2
R:R:L83	R:R:Y284	3.52	1	Yes	Yes	6	7	1	1
R:R:F105	R:R:M109	6.22	1	Yes	Yes	6	5	2	2
R:R:F105	R:R:T159	6.49	1	Yes	No	6	7	2	1
R:R:M109	R:R:T155	4.52	1	Yes	No	5	7	2	2
R:R:M109	R:R:T159	7.53	1	Yes	No	5	7	2	1
R:R:R111	R:R:T283	7.76	1	No	No	8	8	1	2
R:R:R111	R:R:Y284	5.14	1	No	Yes	8	7	1	1
R:R:Q112	R:R:T155	2.83	0	Yes	No	7	7	1	2
R:R:L158	R:R:Q112	2.66	0	No	Yes	5	7	2	1
R:R:E196	R:R:Q112	5.1	0	No	Yes	5	7	2	1
R:R:H161	R:R:L162	6.43	0	No	No	7	4	2	1
R:R:H161	R:R:W188	8.46	0	No	No	7	5	2	2
R:R:H189	R:R:S179	5.58	1	Yes	No	5	4	1	1
R:R:E190	R:R:F180	7	1	Yes	Yes	4	3	2	1
R:R:F180	R:R:F193	3.22	1	Yes	No	3	6	1	2
R:R:F180	R:R:R251	5.34	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	4.29	1	Yes	No	3	4	1	2
R:R:H189	R:R:Q187	9.89	1	Yes	No	5	2	1	2
R:R:M192	R:R:W188	4.65	0	No	No	5	5	1	2
R:R:E190	R:R:H189	2.46	1	Yes	Yes	4	5	2	1
R:R:E190	R:R:R251	11.63	1	Yes	Yes	4	5	2	2
R:R:E196	R:R:F193	5.83	0	No	No	5	6	2	2
R:R:F276	R:R:R251	21.38	1	No	Yes	4	5	2	2
R:R:S178	R:R:S181	1.63	0	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JZ7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.45
Number of Linked Nodes	270
Number of Links	321
Number of Hubs	49
Number of Links mediated by Hubs	185
Number of Communities	9
Number of Nodes involved in Communities	67
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	65382
Length Of Smallest Path	3
Average Path Length	13.5091
Length of Longest Path	30
Minimum Path Strength	1.27
Average Path Strength	4.86828
Maximum Path Strength	16.505
Minimum Path Correlation	0.7
Average Path Correlation	0.919457
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	46.3838
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.462
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • inflammatory cell apoptotic process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • positive regulation of cell communication • establishment of protein localization • system process • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • adiponectin secretion • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of multicellular organismal process • regulation of hormone secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • negative regulation of metabolic process • negative regulation of biological process • regulation of catabolic process • regulation of lipid catabolic process • negative regulation of cellular process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FI7
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FI7
Name	2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid
Synonyms
Identifier
Formula	C19 H22 N4 O5
Molecular Weight	386.402
SMILES
PubChem	135416394
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	0
Total Bonds	52
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8JZ7_nogp_Chain_R F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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