psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D8	R:R:H9	3.78	No	No	0	6	6
2	R:R:D8	R:R:F10	10.75	No	No	0	6	7
3	R:R:F21	R:R:H9	14.71	Yes	No	0	2	6
4	R:R:E12	R:R:L11	3.98	No	No	0	5	8
5	R:R:I13	R:R:L11	11.42	No	No	0	3	8
6	R:R:D14	R:R:K165	4.15	No	No	0	5	4
7	R:R:K16	R:R:T185	15.02	No	No	0	4	2
8	R:R:H184	R:R:N17	3.83	Yes	No	6	3	5
9	R:R:N17	R:R:T263	10.24	No	No	6	5	3
10	R:R:C18	R:R:S181	3.44	No	No	7	9	4
11	R:R:C18	R:R:C183	7.28	No	No	7	9	1
12	R:R:C19	R:R:F21	5.59	No	Yes	3	4	2
13	R:R:C19	R:R:C266	7.28	No	Yes	3	4	7
14	R:R:N171	R:R:V20	4.43	No	No	0	1	2
15	R:R:C266	R:R:F21	6.98	Yes	Yes	3	7	2
16	R:R:F21	R:R:R270	10.69	Yes	No	0	2	1
17	R:R:D273	R:R:F21	7.17	Yes	Yes	3	4	2
18	R:R:R22	R:R:R90	12.79	No	No	0	3	4
19	R:R:R22	R:R:W91	6	No	Yes	0	3	4
20	R:R:D23	R:R:I26	9.8	No	Yes	0	4	5
21	R:R:D23	R:R:R270	3.57	No	No	0	4	1
22	R:R:D23	R:R:L274	5.43	No	No	0	4	1
23	R:R:D24	R:R:K28	5.53	No	No	0	4	3
24	R:R:D24	R:R:R90	14.29	No	No	0	4	4
25	R:R:F25	R:R:K28	3.72	No	No	0	6	3
26	R:R:I26	R:R:V27	4.61	Yes	No	0	5	3
27	R:R:I26	R:R:R90	3.76	Yes	No	0	5	4
28	R:R:I26	R:R:W91	14.09	Yes	Yes	0	5	4
29	R:R:K28	R:R:V27	6.07	No	No	0	3	3
30	R:R:L30	R:R:L34	4.15	No	Yes	8	5	8
31	R:R:L30	R:R:Y87	19.93	No	Yes	8	5	6
32	R:R:P31	R:R:P32	7.79	No	No	0	6	5
33	R:R:E37	R:R:V33	4.28	Yes	No	0	7	5
34	R:R:S281	R:R:V33	3.23	No	No	0	6	5
35	R:R:E37	R:R:L34	3.98	Yes	Yes	0	7	8
36	R:R:L34	R:R:L80	6.92	Yes	No	0	8	8
37	R:R:L34	R:R:M84	5.65	Yes	No	0	8	7
38	R:R:L34	R:R:Y87	3.52	Yes	Yes	8	8	6
39	R:R:G35	R:R:M84	3.49	No	No	0	5	7
40	R:R:I39	R:R:L36	7.14	No	No	0	5	4
41	R:R:E37	R:R:Y284	8.98	Yes	Yes	0	7	7
42	R:R:E37	R:R:M285	9.47	Yes	No	0	7	5
43	R:R:F38	R:R:P81	14.45	No	No	0	7	8
44	R:R:F40	R:R:M288	3.73	No	No	0	6	8
45	R:R:D73	R:R:N45	4.04	No	No	0	9	9
46	R:R:I77	R:R:N45	5.66	No	No	0	6	9
47	R:R:F296	R:R:L47	6.09	No	No	0	8	6
48	R:R:F74	R:R:L49	4.87	No	No	0	7	7
49	R:R:F54	R:R:W50	26.06	No	No	0	4	4
50	R:R:F52	R:R:L56	6.09	Yes	Yes	5	7	5
51	R:R:F52	R:R:W59	10.02	Yes	Yes	5	7	6
52	R:R:F52	R:R:R63	3.21	Yes	No	5	7	7
53	R:R:F52	R:R:F67	11.79	Yes	Yes	5	7	6
54	R:R:F301	R:R:H55	6.79	Yes	No	0	9	5
55	R:R:L56	R:R:W59	4.56	Yes	Yes	5	5	6
56	R:R:L56	R:R:R63	3.64	Yes	No	5	5	7
57	R:R:F301	R:R:L56	8.53	Yes	Yes	0	9	5
58	R:R:K60	R:R:S58	7.65	No	No	0	7	6
59	R:R:F67	R:R:W59	12.03	Yes	Yes	5	6	6
60	R:R:I139	R:R:S61	6.19	No	No	0	7	6
61	R:R:D124	R:R:S62	4.42	No	No	9	8	8
62	R:R:R128	R:R:S62	5.27	No	No	9	8	8
63	R:R:I64	R:R:N141	5.66	No	No	0	7	2
64	R:R:A144	R:R:I64	6.5	No	No	0	7	7
65	R:R:F65	R:R:V120	9.18	No	No	0	7	7
66	R:R:L66	R:R:Y295	9.38	No	Yes	0	8	7
67	R:R:F117	R:R:N68	14.5	No	No	10	8	9
68	R:R:N68	R:R:S148	4.47	No	No	0	9	8
69	R:R:N68	R:R:W152	5.65	No	Yes	10	9	9
70	R:R:D290	R:R:L69	8.14	Yes	No	0	9	9
71	R:R:L69	R:R:Y295	3.52	No	Yes	0	9	7
72	R:R:A72	R:R:W152	3.89	No	Yes	0	8	9
73	R:R:D73	R:R:S287	10.31	No	No	0	9	8
74	R:R:D290	R:R:D73	10.65	Yes	No	0	9	9
75	R:R:F74	R:R:I78	7.54	No	No	0	7	6
76	R:R:L75	R:R:M106	4.24	No	No	1	6	5
77	R:R:L75	R:R:N110	6.87	No	Yes	1	6	9
78	R:R:L76	R:R:N110	6.87	No	Yes	0	7	9
79	R:R:L76	R:R:Y284	3.52	No	Yes	0	7	7
80	R:R:I77	R:R:S287	4.64	No	No	0	6	8
81	R:R:C79	R:R:I78	3.27	No	No	0	6	6
82	R:R:C79	R:R:M106	3.24	No	No	0	6	5
83	R:R:L80	R:R:Y284	11.72	No	Yes	0	8	7
84	R:R:L83	R:R:Y87	17.58	No	Yes	0	6	6
85	R:R:L83	R:R:M103	4.24	No	No	0	6	5
86	L:L:?1	R:R:L83	6.58	Yes	No	0	0	6
87	R:R:D85	R:R:F95	3.58	No	Yes	0	4	7
88	R:R:N86	R:R:W93	13.56	No	Yes	1	5	9
89	R:R:C177	R:R:N86	3.15	No	No	1	9	5
90	R:R:W91	R:R:Y87	4.82	Yes	Yes	0	4	6
91	R:R:R89	R:R:V88	3.92	No	No	0	4	3
92	R:R:D92	R:R:R89	5.96	No	No	0	4	4
93	R:R:K94	R:R:R89	17.33	No	No	0	3	4
94	R:R:N171	R:R:W91	4.52	No	Yes	0	1	4
95	R:R:D92	R:R:N175	6.73	No	No	0	4	4
96	R:R:F95	R:R:W93	28.06	Yes	Yes	0	7	9
97	R:R:C100	R:R:W93	9.14	Yes	Yes	1	9	9
98	R:R:C177	R:R:W93	13.06	No	Yes	1	9	9
99	R:R:F95	R:R:K94	11.17	Yes	No	0	7	3
100	R:R:D97	R:R:K166	15.21	No	No	0	3	4
101	R:R:D97	R:R:M167	4.16	No	Yes	0	3	3
102	R:R:D97	R:R:P168	14.49	No	No	0	3	4
103	R:R:I98	R:R:P99	3.39	No	No	0	2	5
104	R:R:C100	R:R:L104	3.17	Yes	Yes	1	9	5
105	R:R:C100	R:R:M167	6.48	Yes	Yes	1	9	3
106	R:R:C100	R:R:C177	7.28	Yes	No	1	9	9
107	R:R:L104	R:R:R101	7.29	Yes	Yes	1	5	6
108	R:R:L162	R:R:R101	13.36	Yes	Yes	1	4	6
109	R:R:K165	R:R:R101	3.71	No	Yes	0	4	6
110	R:R:M167	R:R:R101	21.09	Yes	Yes	1	3	6
111	R:R:L107	R:R:M103	5.65	No	No	0	6	5
112	R:R:L104	R:R:M167	7.07	Yes	Yes	1	5	3
113	R:R:L104	R:R:S179	7.51	Yes	Yes	1	5	4
114	L:L:?1	R:R:L104	5.26	Yes	Yes	1	0	5
115	R:R:F105	R:R:M109	4.98	Yes	Yes	1	6	5
116	R:R:F105	R:R:T159	6.49	Yes	No	1	6	7
117	R:R:F105	R:R:L162	4.87	Yes	Yes	1	6	4
118	R:R:F105	R:R:L163	18.27	Yes	No	0	6	5
119	R:R:M106	R:R:N110	8.41	No	Yes	1	5	9
120	L:L:?1	R:R:L107	18.41	Yes	No	0	0	6
121	R:R:M109	R:R:N110	5.61	Yes	Yes	1	5	9
122	R:R:M109	R:R:T159	6.02	Yes	No	1	5	7
123	R:R:E196	R:R:R111	4.65	Yes	No	0	5	8
124	R:R:R111	R:R:T283	7.76	No	No	0	8	8
125	L:L:?1	R:R:R111	11.54	Yes	No	0	0	8
126	R:R:Q112	R:R:T155	5.67	Yes	No	0	7	7
127	R:R:L158	R:R:Q112	6.65	No	Yes	0	5	7
128	R:R:M192	R:R:Q112	10.88	No	Yes	0	5	7
129	R:R:E196	R:R:Q112	6.37	Yes	Yes	0	5	7
130	R:R:G113	R:R:I116	3.53	No	No	0	7	5
131	R:R:E196	R:R:I115	4.1	Yes	No	0	5	8
132	R:R:I115	R:R:P200	3.39	No	No	0	8	9
133	R:R:F244	R:R:I115	7.54	Yes	No	0	8	8
134	R:R:F117	R:R:L151	4.87	No	Yes	0	8	7
135	R:R:F117	R:R:W152	11.02	No	Yes	10	8	9
136	R:R:F240	R:R:L118	4.87	Yes	No	0	9	9
137	R:R:L118	R:R:Y294	5.86	No	Yes	0	9	9
138	R:R:P200	R:R:T119	6.99	No	No	0	9	7
139	R:R:I203	R:R:T119	4.56	No	No	0	7	7
140	R:R:R125	R:R:V121	6.54	No	No	0	9	9
141	R:R:D124	R:R:R128	11.91	No	No	9	8	8
142	R:R:I233	R:R:R125	3.76	No	No	0	7	9
143	R:R:F127	R:R:Y126	6.19	Yes	Yes	2	5	7
144	R:R:V130	R:R:Y126	17.66	No	Yes	2	8	7
145	R:R:H131	R:R:Y126	11.98	Yes	Yes	2	7	7
146	R:R:F206	R:R:Y126	4.13	No	Yes	2	4	7
147	R:R:C207	R:R:Y126	4.03	Yes	Yes	0	8	7
148	R:R:R210	R:R:Y126	5.14	No	Yes	2	4	7
149	R:R:F127	R:R:H131	15.84	Yes	Yes	2	5	7
150	R:R:F127	R:R:H134	16.97	Yes	Yes	2	5	4
151	R:R:F127	R:R:L136	6.09	Yes	No	2	5	4
152	R:R:I211	R:R:V129	4.61	No	No	0	8	8
153	R:R:H131	R:R:V130	9.69	Yes	No	2	7	8
154	R:R:H134	R:R:L136	3.86	Yes	No	2	4	4
155	R:R:H134	R:R:N137	7.65	Yes	No	0	4	4
156	R:R:I139	R:R:T143	7.6	No	No	0	7	3
157	R:R:R142	R:R:S140	6.59	No	No	0	4	6
158	R:R:S140	R:R:T143	4.8	No	No	0	6	3
159	R:R:I146	R:R:R142	5.01	No	No	0	3	4
160	R:R:I147	R:R:L151	4.28	No	Yes	0	5	7
161	R:R:L150	R:R:L151	4.15	No	Yes	0	4	7
162	R:R:I154	R:R:L150	7.14	No	No	0	5	4
163	R:R:G153	R:R:I156	3.53	No	No	0	4	4
164	R:R:I154	R:R:L158	4.28	No	No	0	5	5
165	R:R:L163	R:R:V160	5.96	No	No	0	5	4
166	R:R:H161	R:R:L162	12.86	Yes	Yes	1	7	4
167	R:R:H161	R:R:W188	7.41	Yes	No	0	7	5
168	R:R:H161	R:R:H189	3.58	Yes	Yes	1	7	5
169	R:R:H189	R:R:L162	3.86	Yes	Yes	1	5	4
170	R:R:P168	R:R:Q170	6.32	No	No	0	4	1
171	R:R:I169	R:R:L176	9.99	No	No	0	1	4
172	R:R:L176	R:R:N171	21.97	No	No	0	4	1
173	R:R:A174	R:R:N175	3.13	No	No	0	2	4
174	L:L:?1	R:R:S178	4.28	Yes	No	0	0	4
175	R:R:F180	R:R:S179	7.93	No	Yes	1	3	4
176	R:R:H189	R:R:S179	4.18	Yes	Yes	1	5	4
177	L:L:?1	R:R:S179	11.42	Yes	Yes	1	0	4
178	R:R:F180	R:R:F276	4.29	No	Yes	0	3	4
179	L:L:?1	R:R:F180	10.42	Yes	No	1	0	3
180	R:R:C183	R:R:S181	3.44	No	No	7	1	4
181	R:R:I182	R:R:I254	4.42	No	No	0	3	4
182	R:R:I182	R:R:Y269	3.63	No	Yes	3	3	2
183	R:R:D273	R:R:I182	12.59	Yes	No	3	4	3
184	R:R:H184	R:R:L258	12.86	Yes	No	0	3	3
185	R:R:G262	R:R:H184	4.77	No	Yes	0	4	3
186	R:R:H184	R:R:T263	6.85	Yes	No	6	3	3
187	R:R:E190	R:R:F186	3.5	Yes	No	0	4	4
188	R:R:A191	R:R:F186	4.16	No	No	0	3	4
189	R:R:Q187	R:R:W188	6.57	No	No	0	2	5
190	R:R:H189	R:R:Q187	4.95	Yes	No	1	5	2
191	R:R:E190	R:R:Q187	5.1	Yes	No	1	4	2
192	R:R:M192	R:R:W188	12.8	No	No	0	5	5
193	R:R:E190	R:R:H189	3.69	Yes	Yes	1	4	5
194	R:R:E190	R:R:R251	5.82	Yes	Yes	1	4	5
195	R:R:E190	R:R:F255	8.16	Yes	No	1	4	5
196	R:R:E196	R:R:F193	5.83	Yes	No	0	5	6
197	R:R:F193	R:R:S247	5.28	No	No	0	6	6
198	R:R:F193	R:R:R251	3.21	No	Yes	0	6	5
199	R:R:F197	R:R:F198	5.36	Yes	No	0	8	5
200	R:R:F197	R:R:L201	3.65	Yes	Yes	4	8	7
201	R:R:F197	R:R:F240	3.22	Yes	Yes	4	8	9
202	R:R:F197	R:R:L245	3.65	Yes	No	0	8	6
203	R:R:F197	R:R:V248	11.8	Yes	No	0	8	8
204	R:R:L199	R:R:P200	4.93	No	No	0	4	9
205	R:R:I203	R:R:L199	4.28	No	No	0	7	4
206	R:R:F240	R:R:L201	4.87	Yes	Yes	4	9	7
207	R:R:F206	R:R:R210	8.55	No	No	2	4	4
208	R:R:R210	R:R:W213	5	No	No	0	4	3
209	R:R:L215	R:R:M220	4.24	No	No	0	8	3
210	R:R:I226	R:R:L215	4.28	No	No	0	6	8
211	R:R:D221	R:R:R216	11.91	Yes	No	0	3	4
212	R:R:Q217	R:R:R218	4.67	No	No	0	5	5
213	R:R:M220	R:R:R218	4.96	No	No	0	3	5
214	R:R:Q219	R:R:R222	7.01	No	No	0	3	3
215	R:R:H223	R:R:K225	9.17	No	No	0	4	5
216	R:R:F232	R:R:R228	14.97	No	Yes	11	7	7
217	R:R:P299	R:R:R228	12.97	No	Yes	0	5	7
218	R:R:F232	R:R:S297	11.89	No	No	0	7	6
219	R:R:V236	R:R:Y294	7.57	No	Yes	0	8	9
220	R:R:L289	R:R:V239	4.47	No	No	0	7	7
221	R:R:F240	R:R:F244	6.43	Yes	Yes	4	9	8
222	R:R:C243	R:R:F244	4.19	No	Yes	4	8	8
223	R:R:C243	R:R:N286	6.3	No	No	4	8	9
224	R:R:F244	R:R:N286	7.25	Yes	No	4	8	9
225	R:R:P246	R:R:T279	3.5	No	No	0	9	7
226	R:R:F282	R:R:P246	5.78	No	No	0	7	9
227	R:R:S247	R:R:T279	3.2	No	No	0	6	7
228	R:R:F276	R:R:V250	5.24	Yes	No	0	4	5
229	R:R:T279	R:R:V250	3.17	No	No	0	7	5
230	R:R:F255	R:R:R251	13.9	No	Yes	1	5	5
231	R:R:F276	R:R:R251	14.97	Yes	Yes	0	4	5
232	R:R:I254	R:R:V272	6.14	No	No	0	4	4
233	R:R:L257	R:R:S261	4.5	No	Yes	0	3	3
234	R:R:S261	R:R:Y269	6.36	Yes	Yes	0	3	2
235	R:R:N265	R:R:Q264	10.56	No	No	0	5	3
236	R:R:E267	R:R:N265	11.83	No	No	0	2	5
237	R:R:C266	R:R:Y269	5.38	Yes	Yes	3	7	2
238	R:R:V268	R:R:Y269	5.05	No	Yes	0	1	2
239	R:R:D273	R:R:Y269	3.45	Yes	Yes	3	4	2
240	R:R:D273	R:R:V272	5.84	Yes	No	0	4	4
241	R:R:F276	R:R:L280	7.31	Yes	No	0	4	5
242	R:R:F282	R:R:M285	4.98	No	No	0	7	5
243	L:L:?1	R:R:Y284	8.91	Yes	Yes	0	0	7
244	R:R:D290	R:R:N286	5.39	Yes	No	0	9	9
245	R:R:D290	R:R:Y294	6.9	Yes	Yes	0	9	9
246	R:R:V293	R:R:Y294	6.31	No	Yes	0	8	9
247	R:R:Y294	R:R:Y295	4.96	Yes	Yes	0	9	7
248	R:R:S298	R:R:S300	4.89	No	No	0	8	5
249	R:R:F301	R:R:S300	6.61	Yes	No	0	9	5
250	R:R:I278	R:R:V29	3.07	No	No	0	6	5
251	R:R:H133	R:R:P132	3.05	No	No	0	6	8
252	R:R:L69	R:R:S114	3	No	No	0	9	9
253	R:R:L215	R:R:V129	2.98	No	No	0	8	8
254	R:R:L194	R:R:V248	2.98	No	No	0	4	8
255	R:R:L245	R:R:V249	2.98	No	No	0	6	6
256	R:R:I212	R:R:I230	2.94	No	No	0	5	6
257	R:R:I156	R:R:M109	2.92	No	Yes	0	4	5
258	R:R:I212	R:R:M234	2.92	No	No	0	5	4
259	R:R:F95	R:R:P99	2.89	Yes	No	0	7	5
260	R:R:M285	R:R:M288	2.89	No	No	0	5	8
261	R:R:I51	R:R:L47	2.85	No	No	0	7	6
262	R:R:I116	R:R:L151	2.85	No	Yes	0	5	7
263	R:R:I252	R:R:L194	2.85	No	No	0	6	4
264	R:R:C53	R:R:F54	2.79	No	No	0	4	4
265	R:R:P291	R:R:Y295	2.78	No	Yes	0	9	7
266	R:R:L195	R:R:L199	2.77	No	No	0	4	4
267	R:R:L201	R:R:L205	2.77	Yes	No	0	7	4
268	R:R:A70	R:R:Y295	2.67	No	Yes	0	8	7
269	R:R:F65	R:R:S61	2.64	No	No	0	7	6
270	R:R:F65	R:R:S148	2.64	No	No	0	7	8
271	R:R:H161	R:R:K164	2.62	Yes	No	0	7	4
272	R:R:R228	R:R:T231	2.59	Yes	No	11	7	6
273	R:R:F232	R:R:T231	2.59	No	No	11	7	6
274	R:R:F301	R:R:I51	2.51	Yes	No	0	9	7
275	R:R:V71	R:R:W152	2.45	No	Yes	0	6	9
276	R:R:F40	R:R:L36	2.44	No	No	0	6	4
277	R:R:F67	R:R:L49	2.44	Yes	No	0	6	7
278	R:R:L257	R:R:R253	2.43	No	No	0	3	5
279	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
280	R:R:N137	R:R:R128	2.41	No	No	0	4	8
281	R:R:D85	R:R:F82	2.39	No	No	0	4	6
282	R:R:I64	R:R:W59	2.35	No	Yes	0	7	6
283	R:R:G172	R:R:G173	2.11	No	No	0	3	4
284	R:R:R125	R:R:Y294	2.06	No	Yes	0	9	9
285	R:R:G44	R:R:P291	2.03	No	No	0	7	9
286	R:R:A174	R:R:G173	1.95	No	No	0	2	4
287	R:R:A48	R:R:P291	1.87	No	No	0	9	9
288	R:R:G262	R:R:S261	1.86	No	Yes	0	4	3
289	R:R:G157	R:R:V160	1.84	No	No	0	5	4
290	R:R:A122	R:R:C207	1.81	No	Yes	0	9	8
291	R:R:P299	R:R:S298	1.78	No	No	0	5	8
292	R:R:P31	R:R:V88	1.77	No	No	0	6	3
293	R:R:G41	R:R:I77	1.76	No	No	0	8	6
294	R:R:G44	R:R:L43	1.71	No	No	0	7	4
295	R:R:C207	R:R:V123	1.71	Yes	No	0	8	6
296	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
297	R:R:C243	R:R:V239	1.71	No	No	0	8	7
298	R:R:C18	R:R:I13	1.64	No	No	0	9	3
299	R:R:L80	R:R:P81	1.64	No	No	0	8	8
300	R:R:C207	R:R:I203	1.64	Yes	No	0	8	7
301	R:R:S178	R:R:S181	1.63	No	No	0	4	4
302	R:R:A122	R:R:I204	1.62	No	No	0	9	8
303	R:R:S214	R:R:V130	1.62	No	No	0	5	8
304	R:R:A237	R:R:I204	1.62	No	No	0	7	8
305	R:R:A237	R:R:M234	1.61	No	No	0	7	4
306	R:R:V29	R:R:V33	1.6	No	No	0	5	5
307	R:R:V235	R:R:V293	1.6	No	No	0	5	8
308	R:R:S261	R:R:T260	1.6	Yes	No	0	3	1
309	R:R:A108	R:R:L162	1.58	No	Yes	0	4	4
310	R:R:I233	R:R:S208	1.55	No	No	0	7	8
311	R:R:I238	R:R:V235	1.54	No	No	0	5	5
312	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
313	R:R:C266	R:R:E267	1.52	Yes	No	0	7	2
314	R:R:L201	R:R:V241	1.49	Yes	No	0	7	5
315	R:R:A135	R:R:H134	1.46	No	Yes	0	5	4
316	R:R:A224	R:R:H223	1.46	No	No	0	3	4
317	R:R:K15	R:R:K16	1.44	No	No	0	3	4
318	R:R:C53	R:R:F67	1.4	No	Yes	0	4	6
319	R:R:K60	R:R:N141	1.4	No	No	0	7	2
320	R:R:D221	R:R:I226	1.4	Yes	No	0	3	6
321	R:R:D221	R:R:I230	1.4	Yes	No	0	3	6
322	R:R:D14	R:R:K16	1.38	No	No	0	5	4
323	R:R:D221	R:R:Q219	1.31	Yes	No	0	3	3
324	R:R:H259	R:R:L258	1.29	No	No	0	1	3
325	R:R:K227	R:R:R216	1.24	No	No	0	4	4
326	R:R:K225	R:R:R228	1.24	No	Yes	0	5	7
327	L:L:?1	R:R:F277	1.16	Yes	No	0	0	5
328	R:R:L257	R:R:W256	1.14	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F21	9.028	5	3	2
2	R:R:I26	8.065	4	0	5
3	R:R:L34	4.844	5	8	8
4	R:R:E37	6.6775	4	0	7
5	R:R:F52	7.7775	4	5	7
6	R:R:L56	5.705	4	5	5
7	R:R:W59	7.24	4	5	6
8	R:R:F67	6.915	4	5	6
9	R:R:Y87	11.4625	4	8	6
10	R:R:W91	7.3575	4	0	4
11	R:R:W93	15.955	4	1	9
12	R:R:F95	11.425	4	0	7
13	R:R:C100	6.5175	4	1	9
14	R:R:R101	11.3625	4	1	6
15	R:R:L104	6.06	5	1	5
16	R:R:F105	8.6525	4	1	6
17	R:R:M109	4.8825	4	1	5
18	R:R:N110	6.94	4	1	9
19	R:R:Q112	7.3925	4	0	7
20	R:R:Y126	7.36429	7	2	7
21	R:R:F127	11.2725	4	2	5
22	R:R:H131	9.76	4	2	7
23	R:R:H134	7.485	4	2	4
24	R:R:L151	4.0375	4	0	7
25	R:R:W152	5.7525	4	10	9
26	R:R:H161	6.6175	4	1	7
27	R:R:L162	7.306	5	1	4
28	R:R:M167	9.7	4	1	3
29	R:R:S179	7.76	4	1	4
30	R:R:H184	7.0775	4	6	3
31	R:R:H189	4.052	5	1	5
32	R:R:E190	5.254	5	1	4
33	R:R:E196	5.2375	4	0	5
34	R:R:F197	5.536	5	4	8
35	R:R:L201	2.898	5	4	7
36	R:R:C207	2.2975	4	0	8
37	R:R:D221	4.005	4	0	3
38	R:R:R228	7.9425	4	11	7
39	R:R:F240	4.8475	4	4	9
40	R:R:F244	6.3525	4	4	8
41	R:R:R251	9.475	4	1	5
42	R:R:S261	3.58	4	0	3
43	R:R:C266	5.29	4	3	7
44	R:R:Y269	4.774	5	3	2
45	R:R:D273	7.2625	4	3	4
46	R:R:F276	7.9525	4	0	4
47	R:R:Y284	8.2825	4	0	7
48	R:R:D290	7.77	4	0	9
49	R:R:Y294	5.61	6	0	9
50	R:R:Y295	4.662	5	0	7
51	R:R:F301	6.11	4	0	9
52	L:L:?1	8.66444	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F21	R:R:R270	48.0684	10.69	Yes	No	0	2	1
2	R:R:D23	R:R:R270	49.0263	3.57	No	No	0	4	1
3	R:R:D23	R:R:I26	51.2203	9.8	No	Yes	0	4	5
4	R:R:I26	R:R:W91	57.5373	14.09	Yes	Yes	0	5	4
5	R:R:W91	R:R:Y87	66.14	4.82	Yes	Yes	0	4	6
6	R:R:L83	R:R:Y87	49.5617	17.58	No	Yes	0	6	6
7	L:L:?1	R:R:L83	50.6036	6.58	Yes	No	0	0	6
8	L:L:?1	R:R:L104	31.065	5.26	Yes	Yes	1	0	5
9	R:R:C266	R:R:F21	20.8062	6.98	Yes	Yes	3	7	2
10	R:R:C266	R:R:Y269	16.1138	5.38	Yes	Yes	3	7	2
11	R:R:S261	R:R:Y269	27.2202	6.36	Yes	Yes	0	3	2
12	R:R:G262	R:R:S261	14.9249	1.86	No	Yes	0	4	3
13	R:R:G262	R:R:H184	12.4501	4.77	No	Yes	0	4	3
14	R:R:D273	R:R:F21	21.6067	7.17	Yes	Yes	3	4	2
15	R:R:D273	R:R:Y269	15.9852	3.45	Yes	Yes	3	4	2
16	R:R:L34	R:R:Y87	22.0318	3.52	Yes	Yes	8	8	6
17	R:R:C100	R:R:L104	19.5754	3.17	Yes	Yes	1	9	5
18	R:R:C100	R:R:W93	17.8879	9.14	Yes	Yes	1	9	9
19	R:R:F95	R:R:W93	15.9012	28.06	Yes	Yes	0	7	9
20	R:R:F95	R:R:K94	10.7312	11.17	Yes	No	0	7	3
21	R:R:E37	R:R:L34	13.4028	3.98	Yes	Yes	0	7	8
22	R:R:L34	R:R:L80	11.7101	6.92	Yes	No	0	8	8
23	R:R:E37	R:R:Y284	19.8719	8.98	Yes	Yes	0	7	7
24	R:R:L80	R:R:Y284	13.6075	11.72	No	Yes	0	8	7
25	L:L:?1	R:R:Y284	53.144	8.91	Yes	Yes	0	0	7
26	R:R:D290	R:R:N286	29.8289	5.39	Yes	No	0	9	9
27	R:R:F244	R:R:N286	30.4141	7.25	Yes	No	4	8	9
28	R:R:F244	R:R:I115	59.2011	7.54	Yes	No	0	8	8
29	R:R:E196	R:R:I115	100	4.1	Yes	No	0	5	8
30	R:R:E196	R:R:R111	90.1926	4.65	Yes	No	0	5	8
31	L:L:?1	R:R:R111	90.3344	11.54	Yes	No	0	0	8
32	R:R:L76	R:R:Y284	60.8571	3.52	No	Yes	0	7	7
33	R:R:L76	R:R:N110	59.873	6.87	No	Yes	0	7	9
34	R:R:M106	R:R:N110	57.6764	8.41	No	Yes	1	5	9
35	R:R:C79	R:R:M106	56.7342	3.24	No	No	0	6	5
36	R:R:C79	R:R:I78	55.6582	3.27	No	No	0	6	6
37	R:R:F74	R:R:I78	54.5769	7.54	No	No	0	7	6
38	R:R:F74	R:R:L49	53.4747	4.87	No	No	0	7	7
39	R:R:F67	R:R:L49	52.4958	2.44	Yes	No	0	6	7
40	R:R:F52	R:R:F67	21.7143	11.79	Yes	Yes	5	7	6
41	R:R:F52	R:R:L56	19.3234	6.09	Yes	Yes	5	7	5
42	R:R:F301	R:R:L56	36.4555	8.53	Yes	Yes	0	9	5
43	R:R:F67	R:R:W59	26.4723	12.03	Yes	Yes	5	6	6
44	R:R:L56	R:R:W59	19.41	4.56	Yes	Yes	5	5	6
45	R:R:E196	R:R:Q112	25.8765	6.37	Yes	Yes	0	5	7
46	R:R:L158	R:R:Q112	20.6094	6.65	No	Yes	0	5	7
47	R:R:I154	R:R:L158	19.6803	4.28	No	No	0	5	5
48	R:R:I154	R:R:L150	18.7461	7.14	No	No	0	5	4
49	R:R:L150	R:R:L151	17.8065	4.15	No	Yes	0	4	7
50	R:R:F117	R:R:L151	13.9959	4.87	No	Yes	0	8	7
51	R:R:F117	R:R:N68	10.0226	14.5	No	No	10	8	9
52	R:R:F127	R:R:H134	10.7915	16.97	Yes	Yes	2	5	4
53	R:R:F127	R:R:Y126	14.3213	6.19	Yes	Yes	2	5	7
54	R:R:C207	R:R:Y126	50.4409	4.03	Yes	Yes	0	8	7
55	R:R:C207	R:R:I203	63.6652	1.64	Yes	No	0	8	7
56	R:R:I203	R:R:T119	32.6081	4.56	No	No	0	7	7
57	R:R:P200	R:R:T119	33.3745	6.99	No	No	0	9	7
58	R:R:I115	R:R:P200	68.2632	3.39	No	No	0	8	9
59	R:R:I203	R:R:L199	32.7079	4.28	No	No	0	7	4
60	R:R:L199	R:R:P200	34.2405	4.93	No	No	0	4	9
61	R:R:F240	R:R:F244	26.16	6.43	Yes	Yes	4	9	8
62	R:R:F240	R:R:L118	15.8304	4.87	Yes	No	0	9	9
63	R:R:L118	R:R:Y294	14.9433	5.86	No	Yes	0	9	9
64	R:R:Y294	R:R:Y295	13.1351	4.96	Yes	Yes	0	9	7
65	R:R:D290	R:R:Y294	14.841	6.9	Yes	Yes	0	9	9
66	R:R:F105	R:R:L162	15.0404	4.87	Yes	Yes	1	6	4
67	R:R:I211	R:R:Y126	21.4151	2.42	No	Yes	0	8	7
68	R:R:I211	R:R:V129	19.6436	4.61	No	No	0	8	8
69	R:R:E196	R:R:F193	10.5789	5.83	Yes	No	0	5	6
70	R:R:L215	R:R:V129	17.8695	2.98	No	No	0	8	8
71	R:R:I226	R:R:L215	10.7653	4.28	No	No	0	6	8
72	R:R:F301	R:R:S300	24.5197	6.61	Yes	No	0	9	5
73	R:R:S298	R:R:S300	22.0659	4.89	No	No	0	8	5
74	R:R:P299	R:R:S298	19.6069	1.78	No	No	0	5	8
75	R:R:P299	R:R:R228	17.1399	12.97	No	Yes	0	5	7
76	R:R:A122	R:R:C207	10.4398	1.81	No	Yes	0	9	8
77	R:R:P291	R:R:Y295	11.3348	2.78	No	Yes	0	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E37	R:R:Y284	8.98	0	Yes	Yes	7	7	2	1
R:R:L76	R:R:Y284	3.52	0	No	Yes	7	7	2	1
R:R:L80	R:R:Y284	11.72	0	No	Yes	8	7	2	1
R:R:L83	R:R:Y87	17.58	0	No	Yes	6	6	1	2
R:R:L83	R:R:M103	4.24	0	No	No	6	5	1	2
L:L:?1	R:R:L83	6.58	1	Yes	No	0	6	0	1
R:R:C100	R:R:L104	3.17	1	Yes	Yes	9	5	2	1
R:R:C100	R:R:M167	6.48	1	Yes	Yes	9	3	2	2
R:R:L104	R:R:R101	7.29	1	Yes	Yes	5	6	1	2
R:R:M167	R:R:R101	21.09	1	Yes	Yes	3	6	2	2
R:R:L107	R:R:M103	5.65	0	No	No	6	5	1	2
R:R:L104	R:R:M167	7.07	1	Yes	Yes	5	3	1	2
R:R:L104	R:R:S179	7.51	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:L104	5.26	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L107	18.41	1	Yes	No	0	6	0	1
R:R:E196	R:R:R111	4.65	0	Yes	No	5	8	2	1
R:R:R111	R:R:T283	7.76	0	No	No	8	8	1	2
L:L:?1	R:R:R111	11.54	1	Yes	No	0	8	0	1
L:L:?1	R:R:S178	4.28	1	Yes	No	0	4	0	1
R:R:F180	R:R:S179	7.93	1	No	Yes	3	4	1	1
R:R:H189	R:R:S179	4.18	1	Yes	Yes	5	4	2	1
L:L:?1	R:R:S179	11.42	1	Yes	Yes	0	4	0	1
R:R:F180	R:R:F276	4.29	1	No	Yes	3	4	1	2
L:L:?1	R:R:F180	10.42	1	Yes	No	0	3	0	1
L:L:?1	R:R:Y284	8.91	1	Yes	Yes	0	7	0	1
R:R:S178	R:R:S181	1.63	0	No	No	4	4	1	2
L:L:?1	R:R:F277	1.16	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IJB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.13
Number of Linked Nodes	281
Number of Links	328
Number of Hubs	52
Number of Links mediated by Hubs	178
Number of Communities	11
Number of Nodes involved in Communities	66
Number of Links involved in Communities	85

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	80378
Length Of Smallest Path	3
Average Path Length	16.048
Length of Longest Path	37
Minimum Path Strength	1.355
Average Path Strength	6.42457
Maximum Path Strength	20.81
Minimum Path Correlation	0.7
Average Path Correlation	0.920766
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	40.314
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8681
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • cellular process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • protein localization • positive regulation of cell communication • regulation of localization • establishment of protein localization • system process • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • cellular macromolecule localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • cellular localization • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • regulation of cellular localization • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • cellular anatomical structure • cell junction • cell periphery • plasma membrane • membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	OJX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	OJX
Name	5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid
Synonyms
Identifier
Formula	C6 H7 N2 O3
Molecular Weight	155.131
SMILES
PubChem	59806020
Formal Charge	1
Total Atoms	18
Total Chiral Atoms	0
Total Bonds	18
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8IJB_nogp_Chain_R D H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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