psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F10	R:R:H9	15.84	No	No	0	7	6
2	R:R:I13	R:R:L11	4.28	No	No	0	3	8
3	R:R:L11	R:R:V20	2.98	No	No	0	8	2
4	R:R:D14	R:R:I13	5.6	No	No	0	5	3
5	R:R:C18	R:R:I13	4.91	No	No	0	9	3
6	R:R:C18	R:R:K16	3.23	No	Yes	3	9	4
7	R:R:C183	R:R:K16	4.85	No	Yes	3	1	4
8	R:R:K16	R:R:T185	15.02	Yes	No	0	4	2
9	R:R:K16	R:R:Q187	5.42	Yes	No	0	4	2
10	R:R:H184	R:R:N17	5.1	No	No	4	3	5
11	R:R:N17	R:R:T263	5.85	No	No	4	5	3
12	R:R:C18	R:R:C183	7.28	No	No	3	9	1
13	R:R:C19	R:R:C266	7.28	No	No	5	4	7
14	R:R:C19	R:R:Y269	5.38	No	Yes	5	4	2
15	R:R:L176	R:R:V20	4.47	Yes	No	0	4	2
16	R:R:D23	R:R:F21	8.36	No	No	6	4	2
17	R:R:F21	R:R:R270	5.34	No	No	6	2	1
18	R:R:R22	R:R:R90	9.6	No	No	0	3	4
19	R:R:R22	R:R:W91	4	No	Yes	0	3	4
20	R:R:D23	R:R:R270	8.34	No	No	6	4	1
21	R:R:D24	R:R:K28	4.15	No	No	0	4	3
22	R:R:F25	R:R:K28	6.2	No	No	0	6	3
23	R:R:I26	R:R:W91	7.05	No	Yes	0	5	4
24	R:R:I278	R:R:V29	3.07	No	No	0	6	5
25	R:R:L30	R:R:Y87	8.21	Yes	Yes	0	5	6
26	R:R:L30	R:R:S281	4.5	Yes	No	0	5	6
27	R:R:P31	R:R:P32	5.84	No	No	0	6	5
28	R:R:P31	R:R:V88	3.53	No	No	0	6	3
29	R:R:L34	R:R:L80	6.92	No	No	0	8	8
30	R:R:L34	R:R:M84	4.24	No	No	0	8	7
31	R:R:E37	R:R:Y284	3.37	No	Yes	0	7	7
32	R:R:E37	R:R:M285	5.41	No	Yes	0	7	5
33	R:R:E37	R:R:M288	8.12	No	Yes	0	7	8
34	R:R:F38	R:R:L42	13.4	No	No	0	7	7
35	R:R:F38	R:R:P81	20.23	No	No	0	7	8
36	R:R:F40	R:R:I39	5.02	No	No	0	6	5
37	R:R:F40	R:R:M288	3.73	No	Yes	0	6	8
38	R:R:G41	R:R:I77	5.29	No	No	0	8	6
39	R:R:D73	R:R:N45	4.04	Yes	No	0	9	9
40	R:R:F74	R:R:N45	10.87	Yes	No	0	7	9
41	R:R:N45	R:R:P291	4.89	No	No	0	9	9
42	R:R:F296	R:R:L47	7.31	No	No	0	8	6
43	R:R:A48	R:R:Y295	4	No	Yes	0	9	7
44	R:R:F67	R:R:L49	3.65	Yes	No	0	6	7
45	R:R:F74	R:R:L49	6.09	Yes	No	0	7	7
46	R:R:F54	R:R:W50	3.01	No	No	0	4	4
47	R:R:H55	R:R:I51	3.98	No	No	0	5	7
48	R:R:F52	R:R:R63	3.21	Yes	No	0	7	7
49	R:R:F52	R:R:F67	8.57	Yes	Yes	0	7	6
50	R:R:F52	R:R:Y295	5.16	Yes	Yes	0	7	7
51	R:R:C53	R:R:F54	4.19	No	No	0	4	4
52	R:R:R63	R:R:S58	5.27	No	No	0	7	6
53	R:R:K60	R:R:R63	11.14	No	No	0	7	7
54	R:R:I139	R:R:S61	6.19	No	No	0	7	6
55	R:R:D124	R:R:S62	4.42	No	No	0	8	8
56	R:R:I64	R:R:N141	4.25	No	No	0	7	2
57	R:R:F65	R:R:V120	9.18	No	No	0	7	7
58	R:R:L66	R:R:V121	2.98	No	No	0	8	9
59	R:R:L66	R:R:Y295	3.52	No	Yes	0	8	7
60	R:R:F67	R:R:V71	5.24	Yes	No	0	6	6
61	R:R:F117	R:R:N68	16.92	Yes	No	2	8	9
62	R:R:N68	R:R:S148	8.94	No	No	0	9	8
63	R:R:N68	R:R:W152	11.3	No	Yes	2	9	9
64	R:R:D73	R:R:L69	4.07	Yes	Yes	2	9	9
65	R:R:F117	R:R:L69	3.65	Yes	Yes	2	8	9
66	R:R:D290	R:R:L69	4.07	Yes	Yes	2	9	9
67	R:R:L69	R:R:Y295	4.69	Yes	Yes	0	9	7
68	R:R:A70	R:R:Y295	5.34	No	Yes	0	8	7
69	R:R:D73	R:R:S114	4.42	Yes	No	0	9	9
70	R:R:D73	R:R:S287	5.89	Yes	No	0	9	8
71	R:R:D290	R:R:D73	6.65	Yes	Yes	2	9	9
72	R:R:F74	R:R:I78	7.54	Yes	No	0	7	6
73	R:R:L75	R:R:N110	5.49	No	No	0	6	9
74	R:R:L76	R:R:Y284	7.03	No	Yes	0	7	7
75	R:R:I77	R:R:S287	3.1	No	No	0	6	8
76	R:R:C79	R:R:M103	6.48	No	No	0	6	5
77	R:R:C79	R:R:M106	6.48	No	No	0	6	5
78	R:R:C79	R:R:L107	3.17	No	Yes	0	6	6
79	R:R:L80	R:R:L83	5.54	No	Yes	1	8	6
80	R:R:L80	R:R:Y284	8.21	No	Yes	1	8	7
81	R:R:F82	R:R:F95	8.57	No	No	0	6	7
82	R:R:F82	R:R:M103	6.22	No	No	0	6	5
83	R:R:L107	R:R:L83	5.54	Yes	Yes	1	6	6
84	R:R:L83	R:R:Y284	3.52	Yes	Yes	1	6	7
85	L:L:?1	R:R:L83	7.8	Yes	Yes	1	0	6
86	R:R:N86	R:R:Y87	4.65	No	Yes	1	5	6
87	R:R:N86	R:R:W93	7.91	No	Yes	1	5	9
88	L:L:?1	R:R:N86	5.53	Yes	No	1	0	5
89	R:R:W91	R:R:Y87	9.65	Yes	Yes	1	4	6
90	L:L:?1	R:R:Y87	9.44	Yes	Yes	1	0	6
91	R:R:K94	R:R:R89	14.85	No	No	0	3	4
92	R:R:F277	R:R:W91	10.02	No	Yes	0	5	4
93	L:L:?1	R:R:W91	3.67	Yes	Yes	1	0	4
94	R:R:D92	R:R:K94	5.53	No	No	0	4	3
95	R:R:A174	R:R:D92	4.63	No	No	0	2	4
96	R:R:D92	R:R:N175	6.73	No	No	0	4	4
97	R:R:F95	R:R:W93	9.02	No	Yes	0	7	9
98	R:R:C100	R:R:W93	3.92	No	Yes	1	9	9
99	R:R:M103	R:R:W93	3.49	No	Yes	0	5	9
100	R:R:N175	R:R:W93	5.65	No	Yes	0	4	9
101	R:R:C177	R:R:W93	7.84	No	Yes	1	9	9
102	R:R:G96	R:R:P99	4.06	No	No	0	7	5
103	R:R:D97	R:R:I98	4.2	No	No	0	3	2
104	R:R:D97	R:R:P168	3.22	No	No	0	3	4
105	R:R:I98	R:R:P99	3.39	No	No	0	2	5
106	R:R:C100	R:R:P168	9.41	No	No	0	9	4
107	R:R:C100	R:R:C177	7.28	No	No	1	9	9
108	R:R:M167	R:R:R101	4.96	No	No	0	3	6
109	R:R:L102	R:R:M106	5.65	No	No	0	5	5
110	R:R:C177	R:R:L104	4.76	No	No	1	9	5
111	R:R:L104	R:R:S179	3	No	Yes	1	5	4
112	L:L:?1	R:R:L104	7.8	Yes	No	1	0	5
113	R:R:F105	R:R:M109	3.73	Yes	Yes	2	6	5
114	R:R:F105	R:R:I156	3.77	Yes	Yes	2	6	4
115	R:R:F105	R:R:T159	7.78	Yes	No	2	6	7
116	R:R:F105	R:R:L163	12.18	Yes	No	0	6	5
117	R:R:L107	R:R:Y284	4.69	Yes	Yes	1	6	7
118	L:L:?1	R:R:L107	6.69	Yes	Yes	1	0	6
119	R:R:M109	R:R:N110	11.22	Yes	No	0	5	9
120	R:R:M109	R:R:W152	4.65	Yes	Yes	2	5	9
121	R:R:M109	R:R:T155	4.52	Yes	No	0	5	7
122	R:R:I156	R:R:M109	4.37	Yes	Yes	2	4	5
123	R:R:M109	R:R:T159	3.01	Yes	No	2	5	7
124	R:R:F180	R:R:R111	4.28	Yes	No	1	3	8
125	R:R:R111	R:R:Y284	3.09	No	Yes	1	8	7
126	L:L:?1	R:R:R111	12.72	Yes	No	1	0	8
127	R:R:M192	R:R:Q112	8.16	Yes	No	1	5	7
128	R:R:E196	R:R:Q112	8.92	Yes	No	1	5	7
129	R:R:G113	R:R:T155	3.64	No	No	0	7	7
130	R:R:E196	R:R:I115	5.47	Yes	Yes	1	5	8
131	R:R:I115	R:R:P200	3.39	Yes	No	0	8	9
132	R:R:F240	R:R:I115	3.77	Yes	Yes	1	9	8
133	R:R:F244	R:R:I115	7.54	Yes	Yes	1	8	8
134	R:R:I116	R:R:L151	5.71	No	No	0	5	7
135	R:R:F117	R:R:L151	4.87	Yes	No	0	8	7
136	R:R:F117	R:R:W152	13.03	Yes	Yes	2	8	9
137	R:R:F240	R:R:L118	3.65	Yes	No	0	9	9
138	R:R:L118	R:R:Y294	7.03	No	Yes	0	9	9
139	R:R:P200	R:R:T119	5.25	No	No	0	9	7
140	R:R:I203	R:R:T119	4.56	No	No	0	7	7
141	R:R:I204	R:R:T119	3.04	No	No	0	8	7
142	R:R:R125	R:R:V121	6.54	No	No	2	9	9
143	R:R:V121	R:R:Y294	5.05	No	Yes	2	9	9
144	R:R:D124	R:R:R128	9.53	No	No	0	8	8
145	R:R:R125	R:R:Y294	8.23	No	Yes	2	9	9
146	R:R:V130	R:R:Y126	7.57	Yes	Yes	7	8	7
147	R:R:C207	R:R:Y126	6.72	No	Yes	0	8	7
148	R:R:R210	R:R:Y126	3.09	Yes	Yes	7	4	7
149	R:R:F127	R:R:H131	3.39	Yes	No	0	5	7
150	R:R:F127	R:R:L136	4.87	Yes	No	0	5	4
151	R:R:F127	R:R:N137	3.62	Yes	No	0	5	4
152	R:R:N137	R:R:R128	7.23	No	No	0	4	8
153	R:R:I211	R:R:V129	10.75	No	No	0	8	8
154	R:R:L215	R:R:V129	4.47	Yes	No	0	8	8
155	R:R:H131	R:R:V130	4.15	No	Yes	0	7	8
156	R:R:R210	R:R:V130	3.92	Yes	Yes	7	4	8
157	R:R:S214	R:R:V130	4.85	No	Yes	0	5	8
158	R:R:I139	R:R:T143	6.08	No	No	0	7	3
159	R:R:H161	R:R:L162	7.71	No	Yes	0	7	4
160	R:R:H161	R:R:W188	5.29	No	No	0	7	5
161	R:R:L162	R:R:S179	3	Yes	Yes	1	4	4
162	R:R:H189	R:R:L162	15.43	Yes	Yes	1	5	4
163	R:R:K165	R:R:K166	18.68	No	No	0	4	4
164	R:R:L176	R:R:N171	8.24	Yes	No	0	4	1
165	L:L:?1	R:R:S178	6.05	Yes	No	0	0	4
166	R:R:H189	R:R:S179	4.18	Yes	Yes	1	5	4
167	L:L:?1	R:R:S179	8.46	Yes	Yes	1	0	4
168	R:R:F180	R:R:H189	9.05	Yes	Yes	1	3	5
169	R:R:E190	R:R:F180	4.66	Yes	Yes	1	4	3
170	R:R:F180	R:R:F193	13.93	Yes	No	0	3	6
171	R:R:F180	R:R:F276	4.29	Yes	No	0	3	4
172	R:R:F180	R:R:L280	6.09	Yes	No	0	3	5
173	R:R:C183	R:R:S181	3.44	No	No	0	1	4
174	R:R:I182	R:R:R251	3.76	No	Yes	0	3	5
175	R:R:I182	R:R:Y269	3.63	No	Yes	0	3	2
176	R:R:H184	R:R:L258	9	No	No	0	3	3
177	R:R:H184	R:R:T263	6.85	No	No	4	3	3
178	R:R:F186	R:R:F255	10.72	No	No	0	4	5
179	R:R:M192	R:R:W188	4.65	Yes	No	0	5	5
180	R:R:E190	R:R:H189	7.39	Yes	Yes	1	4	5
181	R:R:H189	R:R:M192	3.94	Yes	Yes	1	5	5
182	R:R:E190	R:R:R251	12.79	Yes	Yes	1	4	5
183	R:R:E190	R:R:F255	5.83	Yes	No	1	4	5
184	R:R:E196	R:R:M192	4.06	Yes	Yes	1	5	5
185	R:R:E196	R:R:F193	8.16	Yes	No	0	5	6
186	R:R:L194	R:R:V248	2.98	No	No	0	4	8
187	R:R:L195	R:R:L199	11.07	No	No	0	4	4
188	R:R:F197	R:R:F198	6.43	Yes	No	0	8	5
189	R:R:F197	R:R:L201	12.18	Yes	Yes	1	8	7
190	R:R:F197	R:R:F240	5.36	Yes	Yes	1	8	9
191	R:R:F197	R:R:F244	4.29	Yes	Yes	1	8	8
192	R:R:F197	R:R:V248	9.18	Yes	No	0	8	8
193	R:R:F240	R:R:L201	3.65	Yes	Yes	1	9	7
194	R:R:F240	R:R:I204	7.54	Yes	No	0	9	8
195	R:R:F206	R:R:R210	4.28	No	Yes	0	4	4
196	R:R:I233	R:R:S208	4.64	No	No	0	7	8
197	R:R:R210	R:R:W213	7	Yes	No	0	4	3
198	R:R:I212	R:R:I230	5.89	No	No	0	5	6
199	R:R:L215	R:R:M220	4.24	Yes	No	0	8	3
200	R:R:I230	R:R:L215	4.28	No	Yes	0	6	8
201	R:R:M220	R:R:R218	4.96	No	No	0	3	5
202	R:R:K225	R:R:P299	3.35	No	No	0	5	5
203	R:R:K227	R:R:T231	3	No	No	0	4	6
204	R:R:F232	R:R:R228	8.55	Yes	No	0	7	7
205	R:R:F232	R:R:V293	5.24	Yes	No	0	7	8
206	R:R:F232	R:R:S297	6.61	Yes	No	0	7	6
207	R:R:V236	R:R:V293	4.81	No	No	0	8	8
208	R:R:V236	R:R:Y294	8.83	No	Yes	0	8	9
209	R:R:L289	R:R:V239	4.47	No	No	0	7	7
210	R:R:F240	R:R:F244	9.65	Yes	Yes	1	9	8
211	R:R:C243	R:R:M285	3.24	No	Yes	0	8	5
212	R:R:C243	R:R:N286	3.15	No	No	0	8	9
213	R:R:F244	R:R:N286	6.04	Yes	No	0	8	9
214	R:R:L245	R:R:V249	2.98	Yes	No	0	6	6
215	R:R:P246	R:R:T279	5.25	No	No	0	9	7
216	R:R:I252	R:R:V248	3.07	No	No	0	6	8
217	R:R:F276	R:R:V250	6.55	No	No	0	4	5
218	R:R:F255	R:R:R251	4.28	No	Yes	1	5	5
219	R:R:F276	R:R:R251	9.62	No	Yes	0	4	5
220	R:R:L257	R:R:R253	3.64	No	No	0	3	5
221	R:R:I254	R:R:Y269	6.04	No	Yes	0	4	2
222	R:R:T260	R:R:W256	7.28	No	No	0	1	4
223	R:R:L258	R:R:Y269	3.52	No	Yes	0	3	2
224	R:R:G262	R:R:S261	3.71	No	No	0	4	3
225	R:R:N265	R:R:Q264	5.28	No	No	0	5	3
226	R:R:C266	R:R:Y269	6.72	No	Yes	5	7	2
227	R:R:E267	R:R:R270	10.47	No	No	0	2	1
228	L:L:?1	R:R:L280	8.92	Yes	No	0	0	5
229	R:R:T283	R:R:Y284	4.99	No	Yes	0	8	7
230	L:L:?1	R:R:Y284	8.5	Yes	Yes	1	0	7
231	R:R:L289	R:R:M285	5.65	No	Yes	0	7	5
232	R:R:D290	R:R:N286	9.42	Yes	No	0	9	9
233	R:R:L289	R:R:M288	4.24	No	Yes	0	7	8
234	R:R:D290	R:R:Y294	4.6	Yes	Yes	2	9	9
235	R:R:P291	R:R:Y295	6.95	No	Yes	0	9	7
236	R:R:Y294	R:R:Y295	2.98	Yes	Yes	0	9	7
237	R:R:G262	R:R:Y269	2.9	No	Yes	0	4	2
238	R:R:Q264	R:R:S261	2.89	No	No	0	3	3
239	R:R:I26	R:R:L274	2.85	No	No	0	5	1
240	R:R:I278	R:R:L30	2.85	No	Yes	0	6	5
241	R:R:I77	R:R:L42	2.85	No	No	0	6	7
242	R:R:I51	R:R:L56	2.85	No	No	0	7	5
243	R:R:I139	R:R:L136	2.85	No	No	0	7	4
244	R:R:I147	R:R:L151	2.85	No	No	0	5	7
245	R:R:I154	R:R:L150	2.85	No	No	0	5	4
246	R:R:I154	R:R:L158	2.85	No	No	0	5	5
247	R:R:I226	R:R:L215	2.85	No	Yes	0	6	8
248	R:R:K165	R:R:L162	2.82	No	Yes	0	4	4
249	R:R:D273	R:R:I182	2.8	No	No	0	4	3
250	R:R:C266	R:R:F10	2.79	No	No	0	7	7
251	R:R:C53	R:R:F67	2.79	No	Yes	0	4	6
252	R:R:D23	R:R:L274	2.71	No	No	0	4	1
253	R:R:E12	R:R:K15	2.7	No	No	0	5	3
254	R:R:L158	R:R:Q112	2.66	No	No	0	5	7
255	R:R:H223	R:R:I226	2.65	No	No	0	4	6
256	R:R:F65	R:R:S148	2.64	No	No	0	7	8
257	R:R:N175	R:R:Q170	2.64	No	No	0	4	1
258	R:R:F193	R:R:S247	2.64	No	No	0	6	6
259	R:R:R90	R:R:V27	2.62	No	No	0	4	3
260	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
261	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
262	R:R:F232	R:R:T231	2.59	Yes	No	0	7	6
263	R:R:H134	R:R:L136	2.57	No	No	0	4	4
264	R:R:V268	R:R:Y269	2.52	No	Yes	0	1	2
265	R:R:F52	R:R:I51	2.51	Yes	No	0	7	7
266	R:R:I233	R:R:R125	2.51	No	No	0	7	9
267	R:R:I230	R:R:R216	2.51	No	No	0	6	4
268	R:R:F282	R:R:M285	2.49	No	Yes	0	7	5
269	R:R:F197	R:R:L245	2.44	Yes	Yes	0	8	6
270	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
271	R:R:L47	R:R:W50	2.28	No	No	0	6	4
272	R:R:L257	R:R:W256	2.28	No	No	0	3	4
273	R:R:N141	R:R:W59	2.26	No	No	0	2	6
274	R:R:F186	R:R:H259	2.26	No	No	0	4	1
275	R:R:H223	R:R:R222	2.26	No	No	0	4	3
276	R:R:G172	R:R:G173	2.11	No	No	0	3	4
277	R:R:G157	R:R:V160	1.84	No	No	0	5	4
278	R:R:P299	R:R:S298	1.78	No	No	0	5	8
279	R:R:G153	R:R:I156	1.76	No	Yes	0	4	4
280	R:R:G35	R:R:M84	1.75	No	No	0	5	7
281	R:R:G44	R:R:L43	1.71	No	No	0	7	4
282	R:R:A144	R:R:S61	1.71	No	No	0	7	6
283	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
284	R:R:A237	R:R:S208	1.71	No	No	0	7	8
285	R:R:A275	R:R:V250	1.7	No	No	0	5	5
286	R:R:A108	R:R:T159	1.68	No	No	0	4	7
287	R:R:M167	R:R:P168	1.68	No	No	0	3	4
288	R:R:L30	R:R:P31	1.64	Yes	No	0	5	6
289	R:R:G173	R:R:Q170	1.64	No	No	0	4	1
290	R:R:L199	R:R:P200	1.64	No	No	0	4	9
291	R:R:C207	R:R:I203	1.64	No	No	0	8	7
292	R:R:L245	R:R:P246	1.64	Yes	No	0	6	9
293	R:R:S281	R:R:V33	1.62	No	No	0	6	5
294	R:R:A144	R:R:I64	1.62	No	No	0	7	7
295	R:R:A122	R:R:I204	1.62	No	No	0	9	8
296	R:R:S271	R:R:V272	1.62	No	No	0	3	4
297	R:R:A224	R:R:K225	1.61	No	No	0	3	5
298	R:R:S140	R:R:T143	1.6	No	No	0	6	3
299	R:R:V235	R:R:V293	1.6	No	No	0	5	8
300	R:R:I156	R:R:V160	1.54	Yes	No	0	4	4
301	R:R:I254	R:R:V272	1.54	No	No	0	4	4
302	R:R:H131	R:R:P132	1.53	No	No	0	7	8
303	R:R:F74	R:R:G46	1.51	Yes	No	0	7	4
304	R:R:L176	R:R:S178	1.5	Yes	No	0	4	4
305	R:R:L201	R:R:V241	1.49	Yes	No	0	7	5
306	R:R:L245	R:R:V241	1.49	Yes	No	0	6	5
307	R:R:I238	R:R:I242	1.47	No	No	0	5	5
308	R:R:D24	R:R:V27	1.46	No	No	0	4	3
309	R:R:I238	R:R:M234	1.46	No	No	0	5	4
310	R:R:I169	R:R:L176	1.43	No	Yes	0	1	4
311	R:R:L36	R:R:M288	1.41	No	Yes	0	4	8
312	R:R:D85	R:R:M84	1.39	No	No	0	4	7
313	R:R:L201	R:R:L205	1.38	Yes	No	0	7	4
314	R:R:K164	R:R:R101	1.24	No	No	0	4	6
315	R:R:L257	R:R:Y269	1.17	No	Yes	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:K16	7.13	4	3	4
2	R:R:L30	4.3	4	0	5
3	R:R:F52	4.8625	4	0	7
4	R:R:F67	5.0625	4	0	6
5	R:R:L69	4.12	4	2	9
6	R:R:D73	5.014	5	2	9
7	R:R:F74	6.5025	4	0	7
8	R:R:L83	5.6	4	1	6
9	R:R:Y87	7.9875	4	1	6
10	R:R:W91	6.878	5	1	4
11	R:R:W93	6.305	6	1	9
12	R:R:F105	6.865	4	2	6
13	R:R:L107	5.0225	4	1	6
14	R:R:M109	5.25	6	2	5
15	R:R:I115	5.0425	4	1	8
16	R:R:F117	9.6175	4	2	8
17	R:R:Y126	4.95	4	7	7
18	R:R:F127	3.625	4	0	5
19	R:R:V130	5.1225	4	7	8
20	R:R:W152	7.8925	4	2	9
21	R:R:I156	2.86	4	2	4
22	R:R:L162	7.24	4	1	4
23	R:R:L176	3.91	4	0	4
24	R:R:S179	4.66	4	1	4
25	R:R:F180	7.05	6	1	3
26	R:R:H189	7.998	5	1	5
27	R:R:E190	7.6675	4	1	4
28	R:R:M192	5.2025	4	1	5
29	R:R:E196	6.6525	4	1	5
30	R:R:F197	6.64667	6	1	8
31	R:R:L201	4.082	5	1	7
32	R:R:R210	4.5725	4	7	4
33	R:R:L215	3.96	4	0	8
34	R:R:F232	5.7475	4	0	7
35	R:R:F240	5.60333	6	1	9
36	R:R:F244	6.88	4	1	8
37	R:R:L245	2.1375	4	0	6
38	R:R:R251	7.6125	4	1	5
39	R:R:Y269	3.985	8	5	2
40	R:R:Y284	5.425	8	1	7
41	R:R:M285	4.1975	4	0	5
42	R:R:M288	4.375	4	0	8
43	R:R:D290	6.185	4	2	9
44	R:R:Y294	6.12	6	2	9
45	R:R:Y295	4.66286	7	0	7
46	L:L:?1	7.78	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I182	R:R:Y269	61.5241	3.63	No	Yes	0	3	2
2	R:R:I182	R:R:R251	66.5563	3.76	No	Yes	0	3	5
3	R:R:E190	R:R:R251	44.2195	12.79	Yes	Yes	1	4	5
4	R:R:E190	R:R:F180	28.2741	4.66	Yes	Yes	1	4	3
5	R:R:F180	R:R:R111	35.1939	4.28	Yes	No	1	3	8
6	L:L:?1	R:R:R111	26.1401	12.72	Yes	No	1	0	8
7	L:L:?1	R:R:S178	27.2599	6.05	Yes	No	0	0	4
8	R:R:L176	R:R:S178	25.5133	1.5	Yes	No	0	4	4
9	R:R:L176	R:R:V20	19.6676	4.47	Yes	No	0	4	2
10	R:R:L11	R:R:V20	17.7941	2.98	No	No	0	8	2
11	R:R:I13	R:R:L11	15.8256	4.28	No	No	0	3	8
12	R:R:F276	R:R:R251	24.7667	9.62	No	Yes	0	4	5
13	R:R:F180	R:R:F276	28.172	4.29	Yes	No	0	3	4
14	R:R:F180	R:R:L280	26.6965	6.09	Yes	No	0	3	5
15	L:L:?1	R:R:L280	26.4922	8.92	Yes	No	0	0	5
16	R:R:E190	R:R:H189	23.0693	7.39	Yes	Yes	1	4	5
17	R:R:H189	R:R:S179	32.0351	4.18	Yes	Yes	1	5	4
18	L:L:?1	R:R:S179	23.2067	8.46	Yes	Yes	1	0	4
19	R:R:C18	R:R:I13	11.8675	4.91	No	No	0	9	3
20	R:R:L258	R:R:Y269	12.0259	3.52	No	Yes	0	3	2
21	R:R:I26	R:R:L274	10.2159	2.85	No	No	0	5	1
22	R:R:I26	R:R:W91	12.29	7.05	No	Yes	0	5	4
23	L:L:?1	R:R:W91	26.6507	3.67	Yes	Yes	1	0	4
24	R:R:R22	R:R:W91	12.526	4	No	Yes	0	3	4
25	R:R:R22	R:R:R90	10.4553	9.6	No	No	0	3	4
26	L:L:?1	R:R:Y87	16.22	9.44	Yes	Yes	1	0	6
27	R:R:L30	R:R:Y87	15.7059	8.21	Yes	Yes	0	5	6
28	R:R:E37	R:R:Y284	37.3561	3.37	No	Yes	0	7	7
29	R:R:E37	R:R:M285	36.8102	5.41	No	Yes	0	7	5
30	R:R:F180	R:R:F193	60.9888	13.93	Yes	No	0	3	6
31	R:R:E196	R:R:F193	60.2634	8.16	Yes	No	0	5	6
32	R:R:E196	R:R:I115	100	5.47	Yes	Yes	1	5	8
33	R:R:F244	R:R:I115	31.0878	7.54	Yes	Yes	1	8	8
34	R:R:F244	R:R:N286	35.5002	6.04	Yes	No	0	8	9
35	R:R:D290	R:R:N286	58.8654	9.42	Yes	No	0	9	9
36	R:R:D290	R:R:D73	16.544	6.65	Yes	Yes	2	9	9
37	R:R:H189	R:R:M192	40.3634	3.94	Yes	Yes	1	5	5
38	R:R:E196	R:R:M192	38.5815	4.06	Yes	Yes	1	5	5
39	R:R:F240	R:R:I115	31.292	3.77	Yes	Yes	1	9	8
40	R:R:F240	R:R:L118	31.94	3.65	Yes	No	0	9	9
41	R:R:L118	R:R:Y294	30.9258	7.03	No	Yes	0	9	9
42	R:R:Y294	R:R:Y295	25.0695	2.98	Yes	Yes	0	9	7
43	R:R:F52	R:R:Y295	21.2628	5.16	Yes	Yes	0	7	7
44	R:R:F52	R:R:F67	11.3568	8.57	Yes	Yes	0	7	6
45	R:R:I115	R:R:P200	53.5338	3.39	Yes	No	0	8	9
46	R:R:P200	R:R:T119	49.4031	5.25	No	No	0	9	7
47	R:R:I203	R:R:T119	70.1201	4.56	No	No	0	7	7
48	R:R:C207	R:R:I203	68.3276	1.64	No	No	0	8	7
49	R:R:C207	R:R:Y126	66.5282	6.72	No	Yes	0	8	7
50	R:R:V130	R:R:Y126	38.909	7.57	Yes	Yes	7	8	7
51	R:R:H131	R:R:V130	35.2784	4.15	No	Yes	0	7	8
52	R:R:F127	R:R:H131	31.4188	3.39	Yes	No	0	5	7
53	R:R:F127	R:R:L136	19.9	4.87	Yes	No	0	5	4
54	R:R:I139	R:R:L136	15.9277	2.85	No	No	0	7	4
55	R:R:D290	R:R:L69	37.099	4.07	Yes	Yes	2	9	9
56	R:R:F117	R:R:L69	36.6623	3.65	Yes	Yes	2	8	9
57	R:R:F117	R:R:W152	24.3019	13.03	Yes	Yes	2	8	9
58	R:R:M109	R:R:W152	21.5128	4.65	Yes	Yes	2	5	9
59	R:R:C79	R:R:L107	10.6596	3.17	No	Yes	0	6	6
60	L:L:?1	R:R:N86	28.8481	5.53	Yes	No	1	0	5
61	R:R:N86	R:R:W93	29.0841	7.91	No	Yes	1	5	9
62	R:R:L104	R:R:S179	10.5751	3	No	Yes	1	5	4
63	R:R:C177	R:R:L104	15.8855	4.76	No	No	1	9	5
64	R:R:N175	R:R:W93	19.2379	5.65	No	Yes	0	4	9
65	R:R:C100	R:R:C177	10.0116	7.28	No	No	1	9	9
66	R:R:C100	R:R:P168	14.6741	9.41	No	No	0	9	4
67	R:R:F240	R:R:I204	25.7774	7.54	Yes	No	0	9	8
68	R:R:I211	R:R:Y126	21.6572	2.42	No	Yes	0	8	7
69	R:R:I211	R:R:V129	19.6781	10.75	No	No	0	8	8
70	R:R:L215	R:R:V129	17.6885	4.47	Yes	No	0	8	8
71	R:R:F197	R:R:F240	11.0892	5.36	Yes	Yes	1	8	9
72	R:R:F197	R:R:F244	13.5859	4.29	Yes	Yes	1	8	8
73	R:R:V236	R:R:Y294	10.2264	8.83	No	Yes	0	8	9
74	R:R:C243	R:R:M285	40.2472	3.24	No	Yes	0	8	5
75	R:R:F197	R:R:L245	10.804	2.44	Yes	Yes	0	8	6
76	R:R:L257	R:R:Y269	12.0259	1.17	No	Yes	0	3	2
77	R:R:G262	R:R:Y269	12.0259	2.9	No	Yes	0	4	2
78	L:L:?1	R:R:Y284	29.8024	8.5	Yes	Yes	1	0	7
79	R:R:C243	R:R:N286	40.4092	3.15	No	No	0	8	9
80	R:R:L69	R:R:Y295	13.8994	4.69	Yes	Yes	0	9	7
81	R:R:D290	R:R:Y294	19.6922	4.6	Yes	Yes	2	9	9
82	R:R:I204	R:R:T119	22.5411	3.04	No	No	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R22	R:R:W91	4	0	No	Yes	3	4	2	1
R:R:I26	R:R:W91	7.05	0	No	Yes	5	4	2	1
R:R:L30	R:R:Y87	8.21	0	Yes	Yes	5	6	2	1
R:R:E37	R:R:Y284	3.37	0	No	Yes	7	7	2	1
R:R:L76	R:R:Y284	7.03	0	No	Yes	7	7	2	1
R:R:C79	R:R:L107	3.17	0	No	Yes	6	6	2	1
R:R:L80	R:R:L83	5.54	1	No	Yes	8	6	2	1
R:R:L80	R:R:Y284	8.21	1	No	Yes	8	7	2	1
R:R:L107	R:R:L83	5.54	1	Yes	Yes	6	6	1	1
R:R:L83	R:R:Y284	3.52	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:L83	7.8	1	Yes	Yes	0	6	0	1
R:R:N86	R:R:Y87	4.65	1	No	Yes	5	6	1	1
R:R:N86	R:R:W93	7.91	1	No	Yes	5	9	1	2
L:L:?1	R:R:N86	5.53	1	Yes	No	0	5	0	1
R:R:W91	R:R:Y87	9.65	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:Y87	9.44	1	Yes	Yes	0	6	0	1
R:R:F277	R:R:W91	10.02	0	No	Yes	5	4	2	1
L:L:?1	R:R:W91	3.67	1	Yes	Yes	0	4	0	1
R:R:C177	R:R:W93	7.84	1	No	Yes	9	9	2	2
R:R:C177	R:R:L104	4.76	1	No	No	9	5	2	1
R:R:L104	R:R:S179	3	1	No	Yes	5	4	1	1
L:L:?1	R:R:L104	7.8	1	Yes	No	0	5	0	1
R:R:L107	R:R:Y284	4.69	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:L107	6.69	1	Yes	Yes	0	6	0	1
R:R:F180	R:R:R111	4.28	1	Yes	No	3	8	2	1
R:R:R111	R:R:Y284	3.09	1	No	Yes	8	7	1	1
L:L:?1	R:R:R111	12.72	1	Yes	No	0	8	0	1
R:R:L162	R:R:S179	3	1	Yes	Yes	4	4	2	1
R:R:H189	R:R:L162	15.43	1	Yes	Yes	5	4	2	2
L:L:?1	R:R:S178	6.05	1	Yes	No	0	4	0	1
R:R:H189	R:R:S179	4.18	1	Yes	Yes	5	4	2	1
L:L:?1	R:R:S179	8.46	1	Yes	Yes	0	4	0	1
R:R:F180	R:R:H189	9.05	1	Yes	Yes	3	5	2	2
R:R:F180	R:R:L280	6.09	1	Yes	No	3	5	2	1
L:L:?1	R:R:L280	8.92	1	Yes	No	0	5	0	1
R:R:T283	R:R:Y284	4.99	0	No	Yes	8	7	2	1
L:L:?1	R:R:Y284	8.5	1	Yes	Yes	0	7	0	1
R:R:L176	R:R:S178	1.5	0	Yes	No	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8I7W_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	277
Number of Links	315
Number of Hubs	46
Number of Links mediated by Hubs	172
Number of Communities	7
Number of Nodes involved in Communities	56
Number of Links involved in Communities	77

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	72385
Length Of Smallest Path	3
Average Path Length	13.2889
Length of Longest Path	29
Minimum Path Strength	1.435
Average Path Strength	5.58809
Maximum Path Strength	16.815
Minimum Path Correlation	0.7
Average Path Correlation	0.921025
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	44.4946
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.0004
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	OKL
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	OKL
Name	8-chloranyl-3-pentyl-7H-purine-2,6-dione
Synonyms
Identifier
Formula	C10 H13 Cl N4 O2
Molecular Weight	256.689
SMILES
PubChem	46215799
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8I7W_nogp_Chain_R H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	To be published
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	To be published
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	To be published
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	To be published

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