psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E12	R:R:F10	5.83	No	No	0	5	7
2	R:R:F10	R:R:N17	10.87	No	No	0	7	5
3	R:R:I13	R:R:L11	4.28	Yes	No	0	3	8
4	R:R:L11	R:R:N171	8.24	No	No	0	8	1
5	R:R:D14	R:R:I13	4.2	No	Yes	0	5	3
6	R:R:C18	R:R:I13	4.91	No	Yes	0	9	3
7	R:R:I13	R:R:I169	7.36	Yes	No	0	3	1
8	R:R:D14	R:R:K16	5.53	No	No	0	5	4
9	R:R:K16	R:R:T185	7.51	No	No	6	4	2
10	R:R:K16	R:R:Q187	6.78	No	No	6	4	2
11	R:R:N17	R:R:T263	7.31	No	No	0	5	3
12	H:H:?1	R:R:N17	34.5	No	No	0	0	5
13	R:R:C18	R:R:C183	7.28	No	No	0	9	1
14	R:R:C19	R:R:C266	7.28	No	No	7	4	7
15	R:R:N171	R:R:V20	4.43	No	No	0	1	2
16	R:R:L176	R:R:V20	4.47	No	No	0	4	2
17	R:R:F21	R:R:R270	5.34	No	No	0	2	1
18	R:R:D273	R:R:F21	8.36	No	No	0	4	2
19	R:R:R22	R:R:R90	14.93	Yes	No	0	3	4
20	R:R:R22	R:R:W91	6	Yes	No	0	3	4
21	R:R:N171	R:R:R22	3.62	No	Yes	0	1	3
22	R:R:A174	R:R:R22	5.53	No	Yes	0	2	3
23	R:R:D23	R:R:D24	3.99	No	No	0	4	4
24	R:R:D23	R:R:F25	4.78	No	No	1	4	6
25	R:R:D23	R:R:L274	10.86	No	Yes	1	4	1
26	R:R:F25	R:R:K28	4.96	No	No	0	6	3
27	R:R:F25	R:R:L274	6.09	No	Yes	1	6	1
28	R:R:I26	R:R:L30	5.71	No	No	1	5	5
29	R:R:I26	R:R:Y87	4.84	No	Yes	1	5	6
30	R:R:K28	R:R:V27	4.55	No	No	0	3	3
31	R:R:L30	R:R:Y87	11.72	No	Yes	1	5	6
32	R:R:P31	R:R:P32	5.84	Yes	No	0	6	5
33	R:R:P31	R:R:V88	3.53	Yes	No	0	6	3
34	R:R:E37	R:R:V33	5.7	Yes	No	0	7	5
35	R:R:E37	R:R:L34	5.3	Yes	No	1	7	8
36	R:R:L34	R:R:L80	5.54	No	No	1	8	8
37	R:R:E37	R:R:L80	3.98	Yes	No	1	7	8
38	R:R:E37	R:R:Y284	8.98	Yes	Yes	1	7	7
39	R:R:E37	R:R:M285	6.77	Yes	Yes	0	7	5
40	R:R:F38	R:R:L42	6.09	No	No	0	7	7
41	R:R:F38	R:R:P81	20.23	No	No	0	7	8
42	R:R:F40	R:R:M288	4.98	No	No	0	6	8
43	R:R:G41	R:R:I77	3.53	No	No	0	8	6
44	R:R:G44	R:R:P291	4.06	No	Yes	0	7	9
45	R:R:D73	R:R:N45	6.73	Yes	No	0	9	9
46	R:R:I77	R:R:N45	4.25	No	No	0	6	9
47	R:R:N45	R:R:P291	4.89	No	Yes	0	9	9
48	R:R:F296	R:R:L47	8.53	No	No	0	8	6
49	R:R:A48	R:R:Y295	5.34	No	Yes	0	9	7
50	R:R:F67	R:R:L49	3.65	No	No	0	6	7
51	R:R:F74	R:R:L49	3.65	No	No	0	7	7
52	R:R:H55	R:R:I51	3.98	No	No	0	5	7
53	R:R:F52	R:R:R63	5.34	No	Yes	0	7	7
54	R:R:F52	R:R:Y295	4.13	No	Yes	0	7	7
55	R:R:F67	R:R:W59	8.02	No	No	0	6	6
56	R:R:I139	R:R:S61	7.74	No	No	0	7	6
57	R:R:D124	R:R:S62	7.36	No	No	8	8	8
58	R:R:R128	R:R:S62	9.22	Yes	No	8	8	8
59	R:R:F65	R:R:V120	7.87	No	No	0	7	7
60	R:R:L66	R:R:Y294	4.69	No	Yes	4	8	9
61	R:R:L66	R:R:Y295	9.38	No	Yes	4	8	7
62	R:R:F67	R:R:V71	5.24	No	No	0	6	6
63	R:R:F117	R:R:N68	12.08	Yes	No	2	8	9
64	R:R:N68	R:R:S148	8.94	No	No	0	9	8
65	R:R:N68	R:R:W152	5.65	No	Yes	2	9	9
66	R:R:D290	R:R:L69	5.43	Yes	No	0	9	9
67	R:R:L69	R:R:Y295	7.03	No	Yes	0	9	7
68	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
69	R:R:D73	R:R:S114	4.42	Yes	No	0	9	9
70	R:R:D73	R:R:S287	11.78	Yes	No	0	9	8
71	R:R:D290	R:R:D73	6.65	Yes	Yes	0	9	9
72	R:R:F74	R:R:I78	3.77	No	No	0	7	6
73	R:R:L75	R:R:M106	4.24	No	No	9	6	5
74	R:R:L75	R:R:N110	9.61	No	Yes	9	6	9
75	R:R:L76	R:R:N110	4.12	No	Yes	0	7	9
76	R:R:L76	R:R:S287	4.5	No	No	0	7	8
77	R:R:C79	R:R:L107	4.76	No	No	0	6	6
78	R:R:L80	R:R:Y284	7.03	No	Yes	1	8	7
79	R:R:L83	R:R:Y87	7.03	No	Yes	1	6	6
80	R:R:L107	R:R:L83	4.15	No	No	1	6	6
81	L:L:?1	R:R:L83	3.78	Yes	No	1	0	6
82	R:R:D85	R:R:R89	7.15	No	No	10	4	4
83	R:R:D85	R:R:K94	8.3	No	No	10	4	3
84	R:R:D85	R:R:F95	7.17	No	No	0	4	7
85	R:R:N86	R:R:W93	9.04	No	Yes	0	5	9
86	L:L:?1	R:R:N86	3.75	Yes	No	0	0	5
87	L:L:?1	R:R:Y87	9.61	Yes	Yes	1	0	6
88	R:R:D92	R:R:R89	3.57	No	No	0	4	4
89	R:R:K94	R:R:R89	16.09	No	No	10	3	4
90	R:R:F277	R:R:W91	11.02	No	No	1	5	4
91	L:L:?1	R:R:W91	6.23	Yes	No	1	0	4
92	R:R:F95	R:R:W93	14.03	No	Yes	0	7	9
93	R:R:C100	R:R:W93	7.84	No	Yes	11	9	9
94	R:R:M103	R:R:W93	5.82	No	Yes	0	5	9
95	R:R:C177	R:R:W93	14.37	No	Yes	11	9	9
96	R:R:D97	R:R:R101	13.1	No	Yes	5	3	6
97	R:R:D97	R:R:K166	5.53	No	No	5	3	4
98	R:R:D97	R:R:P168	11.27	No	No	5	3	4
99	R:R:I98	R:R:R101	8.77	No	Yes	0	2	6
100	R:R:C100	R:R:C177	7.28	No	No	11	9	9
101	R:R:K166	R:R:R101	8.66	No	Yes	5	4	6
102	L:L:?1	R:R:L104	3.78	Yes	No	0	0	5
103	R:R:F105	R:R:M109	4.98	No	No	0	6	5
104	R:R:F105	R:R:L163	6.09	No	No	0	6	5
105	R:R:M106	R:R:N110	8.41	No	Yes	9	5	9
106	L:L:?1	R:R:L107	10.09	Yes	No	1	0	6
107	R:R:M109	R:R:N110	4.21	No	Yes	0	5	9
108	R:R:I156	R:R:M109	4.37	No	No	0	4	5
109	R:R:E196	R:R:R111	6.98	No	Yes	0	5	8
110	R:R:R111	R:R:T283	3.88	Yes	No	1	8	8
111	R:R:R111	R:R:Y284	4.12	Yes	Yes	1	8	7
112	L:L:?1	R:R:R111	9.96	Yes	Yes	1	0	8
113	R:R:I116	R:R:Q112	4.12	Yes	Yes	2	5	7
114	R:R:Q112	R:R:T155	5.67	Yes	No	0	7	7
115	R:R:L158	R:R:Q112	9.32	No	Yes	2	5	7
116	R:R:Q112	R:R:T159	4.25	Yes	No	2	7	7
117	R:R:M192	R:R:Q112	5.44	No	Yes	2	5	7
118	R:R:E196	R:R:Q112	8.92	No	Yes	0	5	7
119	R:R:E196	R:R:I115	5.47	No	No	0	5	8
120	R:R:F244	R:R:I115	6.28	Yes	No	0	8	8
121	R:R:F117	R:R:I116	5.02	Yes	Yes	2	8	5
122	R:R:I116	R:R:L151	5.71	Yes	No	2	5	7
123	R:R:F117	R:R:L151	9.74	Yes	No	2	8	7
124	R:R:F117	R:R:W152	10.02	Yes	Yes	2	8	9
125	R:R:I203	R:R:T119	6.08	No	No	0	7	7
126	R:R:I204	R:R:T119	4.56	Yes	No	0	8	7
127	R:R:R125	R:R:V121	6.54	No	No	4	9	9
128	R:R:V121	R:R:Y294	3.79	No	Yes	4	9	9
129	R:R:D124	R:R:R128	8.34	No	Yes	8	8	8
130	R:R:R125	R:R:Y294	7.2	No	Yes	4	9	9
131	R:R:V130	R:R:Y126	13.88	Yes	Yes	3	8	7
132	R:R:H131	R:R:Y126	8.71	Yes	Yes	3	7	7
133	R:R:F206	R:R:Y126	6.19	No	Yes	3	4	7
134	R:R:C207	R:R:Y126	8.06	No	Yes	0	8	7
135	R:R:R210	R:R:Y126	7.2	Yes	Yes	3	4	7
136	R:R:I211	R:R:Y126	3.63	No	Yes	0	8	7
137	R:R:F127	R:R:H131	4.53	Yes	Yes	3	5	7
138	R:R:F127	R:R:H134	10.18	Yes	No	3	5	4
139	R:R:F127	R:R:L136	3.65	Yes	No	3	5	4
140	R:R:N137	R:R:R128	4.82	No	Yes	0	4	8
141	R:R:I211	R:R:V129	9.22	No	No	0	8	8
142	R:R:L215	R:R:V129	4.47	No	No	0	8	8
143	R:R:H131	R:R:V130	8.3	Yes	Yes	3	7	8
144	R:R:R210	R:R:V130	6.54	Yes	Yes	3	4	8
145	R:R:S214	R:R:V130	6.46	No	Yes	0	5	8
146	R:R:H133	R:R:P132	6.1	No	No	0	6	8
147	R:R:H134	R:R:L136	3.86	No	No	3	4	4
148	R:R:I139	R:R:T143	4.56	No	No	0	7	3
149	R:R:S140	R:R:T143	4.8	No	No	0	6	3
150	R:R:T155	R:R:W152	4.85	No	Yes	0	7	9
151	R:R:G157	R:R:I156	3.53	No	No	0	5	4
152	R:R:G157	R:R:V160	3.68	No	No	0	5	4
153	R:R:L158	R:R:W188	4.56	No	No	0	5	5
154	R:R:L158	R:R:M192	4.24	No	No	2	5	5
155	R:R:M192	R:R:T159	4.52	No	No	2	5	7
156	R:R:H161	R:R:L162	6.43	No	No	0	7	4
157	R:R:H189	R:R:L162	5.14	Yes	No	0	5	4
158	R:R:K165	R:R:M167	10.08	No	No	0	4	3
159	R:R:K166	R:R:P168	5.02	No	No	5	4	4
160	R:R:I169	R:R:L176	4.28	No	No	0	1	4
161	R:R:N175	R:R:Q170	6.6	No	No	0	4	1
162	L:L:?1	R:R:S178	5.47	Yes	No	0	0	4
163	R:R:H189	R:R:S179	5.58	Yes	No	0	5	4
164	L:L:?1	R:R:S179	6.84	Yes	No	0	0	4
165	R:R:F180	R:R:H189	12.44	Yes	Yes	0	3	5
166	R:R:F180	R:R:F193	9.65	Yes	No	1	3	6
167	R:R:F180	R:R:F276	7.5	Yes	Yes	1	3	4
168	R:R:F180	R:R:L280	3.65	Yes	No	1	3	5
169	L:L:?1	R:R:F180	8.88	Yes	Yes	1	0	3
170	R:R:I182	R:R:I254	7.36	Yes	No	0	3	4
171	R:R:I182	R:R:L258	4.28	Yes	No	12	3	3
172	R:R:I182	R:R:Y269	4.84	Yes	Yes	12	3	2
173	R:R:D273	R:R:I182	5.6	No	Yes	0	4	3
174	R:R:H184	R:R:L258	3.86	No	No	0	3	3
175	R:R:Q187	R:R:T185	4.25	No	No	6	2	2
176	R:R:E190	R:R:R251	15.12	No	Yes	1	4	5
177	R:R:E190	R:R:F255	9.33	No	No	1	4	5
178	R:R:F193	R:R:S247	6.61	No	No	0	6	6
179	R:R:F193	R:R:F276	4.29	No	Yes	1	6	4
180	R:R:F255	R:R:L194	3.65	No	No	0	5	4
181	R:R:F197	R:R:F198	5.36	Yes	No	0	8	5
182	R:R:F197	R:R:L201	8.53	Yes	Yes	1	8	7
183	R:R:F197	R:R:F240	5.36	Yes	Yes	1	8	9
184	R:R:F197	R:R:F244	4.29	Yes	Yes	1	8	8
185	R:R:F197	R:R:L245	7.31	Yes	No	0	8	6
186	R:R:F197	R:R:V248	5.24	Yes	No	0	8	8
187	R:R:L201	R:R:L205	8.3	Yes	No	0	7	4
188	R:R:F240	R:R:L201	3.65	Yes	Yes	1	9	7
189	R:R:F240	R:R:I204	5.02	Yes	Yes	0	9	8
190	R:R:F206	R:R:R210	5.34	No	Yes	3	4	4
191	R:R:I211	R:R:I233	4.42	No	No	0	8	7
192	R:R:I212	R:R:I230	4.42	No	No	0	5	6
193	R:R:I212	R:R:I233	5.89	No	No	0	5	7
194	R:R:I212	R:R:M234	4.37	No	No	0	5	4
195	R:R:I230	R:R:L215	4.28	No	No	0	6	8
196	R:R:D221	R:R:R216	5.96	No	No	0	3	4
197	R:R:H223	R:R:I226	5.3	No	No	0	4	6
198	R:R:K225	R:R:P299	6.69	No	No	0	5	5
199	R:R:F232	R:R:R228	9.62	No	No	0	7	7
200	R:R:P299	R:R:R228	8.65	No	No	0	5	7
201	R:R:F232	R:R:T231	3.89	No	No	0	7	6
202	R:R:F232	R:R:S297	9.25	No	No	0	7	6
203	R:R:V236	R:R:Y294	10.09	No	Yes	0	8	9
204	R:R:L289	R:R:V239	4.47	No	No	0	7	7
205	R:R:F240	R:R:F244	5.36	Yes	Yes	1	9	8
206	R:R:F244	R:R:T283	3.89	Yes	No	1	8	8
207	R:R:F244	R:R:N286	8.46	Yes	No	0	8	9
208	R:R:F276	R:R:V250	3.93	Yes	No	0	4	5
209	R:R:T279	R:R:V250	4.76	No	No	0	7	5
210	R:R:I254	R:R:R251	5.01	No	Yes	0	4	5
211	R:R:F255	R:R:R251	9.62	No	Yes	1	5	5
212	R:R:F276	R:R:R251	13.9	Yes	Yes	1	4	5
213	R:R:L257	R:R:R253	9.72	No	No	0	3	5
214	R:R:I254	R:R:V272	6.14	No	No	0	4	4
215	R:R:T260	R:R:W256	7.28	No	No	0	1	4
216	R:R:L257	R:R:Y269	7.03	No	Yes	0	3	2
217	R:R:L258	R:R:Y269	8.21	No	Yes	12	3	2
218	R:R:G262	R:R:S261	3.71	No	No	0	4	3
219	H:H:?1	R:R:Q264	7.17	No	No	0	0	3
220	R:R:E267	R:R:N265	5.26	No	No	0	2	5
221	R:R:E267	R:R:R270	9.3	No	No	0	2	1
222	R:R:V268	R:R:Y269	5.05	No	Yes	0	1	2
223	R:R:D273	R:R:F277	7.17	No	No	0	4	5
224	R:R:F276	R:R:L280	6.09	Yes	No	1	4	5
225	L:L:?1	R:R:F277	4.44	Yes	No	1	0	5
226	L:L:?1	R:R:L280	5.05	Yes	No	1	0	5
227	R:R:F282	R:R:S281	3.96	No	No	0	7	6
228	R:R:T283	R:R:Y284	4.99	No	Yes	1	8	7
229	L:L:?1	R:R:Y284	6.41	Yes	Yes	1	0	7
230	R:R:M285	R:R:M288	4.33	Yes	No	0	5	8
231	R:R:D290	R:R:N286	12.12	Yes	No	0	9	9
232	R:R:D290	R:R:Y294	5.75	Yes	Yes	0	9	9
233	R:R:P291	R:R:Y295	4.17	Yes	Yes	0	9	7
234	R:R:Y294	R:R:Y295	3.97	Yes	Yes	4	9	7
235	R:R:P299	R:R:S298	3.56	No	No	0	5	8
236	R:R:P200	R:R:T119	3.5	No	No	0	9	7
237	R:R:P246	R:R:T279	3.5	No	No	0	9	7
238	R:R:G44	R:R:L43	3.42	No	No	0	7	4
239	R:R:L47	R:R:W50	3.42	No	No	0	6	4
240	R:R:F54	R:R:H55	3.39	No	No	0	4	5
241	R:R:I98	R:R:P99	3.39	No	No	0	2	5
242	R:R:C19	R:R:T263	3.38	No	No	7	4	3
243	R:R:C266	R:R:T263	3.38	No	No	7	7	3
244	R:R:M84	R:R:P31	3.35	No	Yes	0	7	6
245	R:R:Q217	R:R:W213	3.29	No	No	0	5	3
246	R:R:L199	R:R:P200	3.28	No	No	0	4	9
247	R:R:S178	R:R:S181	3.26	No	No	0	4	4
248	R:R:A144	R:R:I64	3.25	No	No	0	7	7
249	R:R:C243	R:R:M285	3.24	No	Yes	0	8	5
250	R:R:S281	R:R:V33	3.23	No	No	0	6	5
251	R:R:V235	R:R:V293	3.21	No	No	0	5	8
252	R:R:G262	R:R:H184	3.18	No	No	0	4	3
253	R:R:I64	R:R:S148	3.1	No	No	0	7	8
254	R:R:I233	R:R:S208	3.1	No	No	0	7	8
255	R:R:I278	R:R:V29	3.07	No	No	0	6	5
256	R:R:K60	R:R:S58	3.06	No	No	0	7	6
257	R:R:L245	R:R:V241	2.98	No	No	0	6	5
258	R:R:L245	R:R:V249	2.98	No	No	0	6	6
259	R:R:I116	R:R:I154	2.94	Yes	No	0	5	5
260	R:R:A108	R:R:H189	2.93	No	Yes	0	4	5
261	R:R:F296	R:R:P291	2.89	No	Yes	0	8	9
262	R:R:I26	R:R:L274	2.85	No	Yes	1	5	1
263	R:R:I77	R:R:L42	2.85	No	No	0	6	7
264	R:R:I51	R:R:L47	2.85	No	No	0	7	6
265	R:R:I204	R:R:L118	2.85	Yes	No	0	8	9
266	R:R:I147	R:R:L151	2.85	No	No	0	5	7
267	R:R:I278	R:R:L274	2.85	No	Yes	0	6	1
268	R:R:L104	R:R:M167	2.83	No	No	0	5	3
269	R:R:L289	R:R:M285	2.83	No	Yes	0	7	5
270	R:R:P31	R:R:Y87	2.78	Yes	Yes	0	6	6
271	R:R:A144	R:R:F65	2.77	No	No	0	7	7
272	R:R:R63	R:R:S298	2.64	Yes	No	0	7	8
273	R:R:R63	R:R:S300	2.64	Yes	No	0	7	5
274	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
275	R:R:H223	R:R:K225	2.62	No	No	0	4	5
276	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
277	R:R:A191	R:R:W188	2.59	No	No	0	3	5
278	R:R:M167	R:R:R101	2.48	No	Yes	0	3	6
279	R:R:M220	R:R:R218	2.48	No	No	0	3	5
280	R:R:F74	R:R:L42	2.44	No	No	0	7	7
281	R:R:L56	R:R:R63	2.43	No	Yes	0	5	7
282	R:R:G172	R:R:G173	2.11	No	No	0	3	4
283	R:R:G96	R:R:P99	2.03	No	No	0	7	5
284	R:R:A72	R:R:G113	1.95	No	No	0	8	7
285	R:R:G35	R:R:M84	1.75	No	No	0	5	7
286	R:R:G46	R:R:L49	1.71	No	No	0	4	7
287	R:R:A144	R:R:S61	1.71	No	No	0	7	6
288	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
289	R:R:A237	R:R:S208	1.71	No	No	0	7	8
290	R:R:A275	R:R:V250	1.7	No	No	0	5	5
291	R:R:C207	R:R:I203	1.64	No	No	0	8	7
292	R:R:A145	R:R:I64	1.62	No	No	0	3	7
293	R:R:A122	R:R:I204	1.62	No	Yes	0	9	8
294	R:R:V235	R:R:V239	1.6	No	No	0	5	7
295	R:R:V236	R:R:V293	1.6	No	No	0	8	8
296	R:R:S261	R:R:T260	1.6	No	No	0	3	1
297	R:R:V292	R:R:V293	1.6	No	No	0	6	8
298	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
299	R:R:I238	R:R:I242	1.47	No	No	0	5	5
300	R:R:A224	R:R:H223	1.46	No	No	0	3	4
301	R:R:I154	R:R:L150	1.43	No	No	0	5	4
302	R:R:I252	R:R:L194	1.43	No	No	0	6	4
303	R:R:L215	R:R:M220	1.41	No	No	0	8	3
304	R:R:D221	R:R:I230	1.4	No	No	0	3	6
305	R:R:R128	R:R:S61	1.32	Yes	No	0	8	6
306	R:R:R142	R:R:S140	1.32	No	No	0	4	6
307	R:R:F186	R:R:T185	1.3	No	No	0	4	2
308	R:R:F10	R:R:H9	1.13	No	No	0	7	6
309	R:R:N141	R:R:W59	1.13	No	No	0	2	6
310	R:R:N175	R:R:W93	1.13	No	Yes	0	4	9
311	R:R:R210	R:R:W213	1	Yes	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I13	5.1875	4	0	3
2	R:R:R22	7.52	4	0	3
3	R:R:P31	3.875	4	0	6
4	R:R:E37	6.146	5	1	7
5	R:R:R63	3.2625	4	0	7
6	R:R:D73	7.395	4	0	9
7	R:R:Y87	7.196	5	1	6
8	R:R:W93	8.705	6	11	9
9	R:R:R101	8.2525	4	5	6
10	R:R:N110	6.5875	4	9	9
11	R:R:R111	6.235	4	1	8
12	R:R:Q112	6.28667	6	2	7
13	R:R:I116	4.4475	4	2	5
14	R:R:F117	9.215	4	2	8
15	R:R:Y126	7.945	6	3	7
16	R:R:F127	5.245	4	3	5
17	R:R:R128	5.925	4	8	8
18	R:R:V130	8.795	4	3	8
19	R:R:H131	5.7675	4	3	7
20	R:R:W152	5.7775	4	2	9
21	R:R:F180	8.424	5	1	3
22	R:R:I182	5.52	4	12	3
23	R:R:H189	6.5225	4	0	5
24	R:R:F197	6.015	6	1	8
25	R:R:L201	5.5475	4	1	7
26	R:R:I204	3.5125	4	0	8
27	R:R:R210	5.02	4	3	4
28	R:R:F240	4.8475	4	1	9
29	R:R:F244	5.656	5	1	8
30	R:R:R251	10.9125	4	1	5
31	R:R:Y269	6.2825	4	12	2
32	R:R:L274	5.6625	4	1	1
33	R:R:F276	7.142	5	1	4
34	R:R:Y284	6.306	5	1	7
35	R:R:M285	4.2925	4	0	5
36	R:R:D290	7.4875	4	0	9
37	R:R:P291	4.0025	4	0	9
38	R:R:Y294	5.915	6	4	9
39	R:R:Y295	5.43143	7	4	7
40	L:L:?1	6.48385	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I13	R:R:L11	11.4339	4.28	Yes	No	0	3	8
2	R:R:L11	R:R:N171	12.6958	8.24	No	No	0	8	1
3	R:R:D273	R:R:F277	21.3974	7.17	No	No	0	4	5
4	R:R:R22	R:R:W91	21.4715	6	Yes	No	0	3	4
5	R:R:N171	R:R:R22	17.7626	3.62	No	Yes	0	1	3
6	R:R:I26	R:R:L274	10.5094	2.85	No	Yes	1	5	1
7	R:R:I26	R:R:Y87	11.7741	4.84	No	Yes	1	5	6
8	L:L:?1	R:R:Y87	20.3577	9.61	Yes	Yes	1	0	6
9	L:L:?1	R:R:W91	21.5949	6.23	Yes	No	1	0	4
10	L:L:?1	R:R:Y284	53.2329	6.41	Yes	Yes	1	0	7
11	R:R:I77	R:R:L42	12.5202	2.85	No	No	0	6	7
12	R:R:I77	R:R:N45	14.7478	4.25	No	No	0	6	9
13	R:R:D73	R:R:N45	24.0639	6.73	Yes	No	0	9	9
14	R:R:D290	R:R:D73	36.938	6.65	Yes	Yes	0	9	9
15	R:R:D290	R:R:N286	90.6482	12.12	Yes	No	0	9	9
16	R:R:F244	R:R:N286	91.3505	8.46	Yes	No	0	8	9
17	R:R:F244	R:R:T283	100	3.89	Yes	No	1	8	8
18	R:R:R111	R:R:T283	48.232	3.88	Yes	No	1	8	8
19	L:L:?1	R:R:R111	64.0194	9.96	Yes	Yes	1	0	8
20	R:R:T283	R:R:Y284	52.1823	4.99	No	Yes	1	8	7
21	R:R:N45	R:R:P291	11.0224	4.89	No	Yes	0	9	9
22	R:R:P291	R:R:Y295	19.8365	4.17	Yes	Yes	0	9	7
23	R:R:L69	R:R:Y295	25.0981	7.03	No	Yes	0	9	7
24	R:R:D290	R:R:L69	26.0637	5.43	Yes	No	0	9	9
25	R:R:Y294	R:R:Y295	26.3435	3.97	Yes	Yes	4	9	7
26	R:R:D290	R:R:Y294	30.9494	5.75	Yes	Yes	0	9	9
27	R:R:F296	R:R:P291	18.399	2.89	No	Yes	0	8	9
28	R:R:F296	R:R:L47	15.3458	8.53	No	No	0	8	6
29	R:R:F52	R:R:Y295	28.8262	4.13	No	Yes	0	7	7
30	R:R:F52	R:R:R63	26.9607	5.34	No	Yes	0	7	7
31	R:R:E196	R:R:R111	18.3853	6.98	No	Yes	0	5	8
32	R:R:E196	R:R:Q112	37.4345	8.92	No	Yes	0	5	7
33	R:R:I116	R:R:Q112	17.598	4.12	Yes	Yes	2	5	7
34	R:R:F117	R:R:I116	13.7163	5.02	Yes	Yes	2	8	5
35	R:R:F117	R:R:N68	13.0085	12.08	Yes	No	2	8	9
36	R:R:N68	R:R:S148	24.2449	8.94	No	No	0	9	8
37	R:R:I64	R:R:S148	22.6401	3.1	No	No	0	7	8
38	R:R:A144	R:R:I64	19.414	3.25	No	No	0	7	7
39	R:R:A144	R:R:S61	14.6106	1.71	No	No	0	7	6
40	R:R:Q112	R:R:T155	15.8972	5.67	Yes	No	0	7	7
41	R:R:T155	R:R:W152	15.1373	4.85	No	Yes	0	7	9
42	R:R:N68	R:R:W152	12.833	5.65	No	Yes	2	9	9
43	R:R:D73	R:R:S287	13.3652	11.78	Yes	No	0	9	8
44	R:R:L76	R:R:S287	12.1773	4.5	No	No	0	7	8
45	R:R:L76	R:R:N110	10.984	4.12	No	Yes	0	7	9
46	R:R:N86	R:R:W93	14.1278	9.04	No	Yes	0	5	9
47	L:L:?1	R:R:N86	15.2141	3.75	Yes	No	0	0	5
48	R:R:M167	R:R:R101	10.4655	2.48	No	Yes	0	3	6
49	R:R:L104	R:R:M167	12.8494	2.83	No	No	0	5	3
50	L:L:?1	R:R:L104	14.1223	3.78	Yes	No	0	0	5
51	R:R:E196	R:R:I115	20.4373	5.47	No	No	0	5	8
52	R:R:F240	R:R:F244	45.9167	5.36	Yes	Yes	1	9	8
53	R:R:F240	R:R:I204	42.526	5.02	Yes	Yes	0	9	8
54	R:R:I204	R:R:T119	39.5578	4.56	Yes	No	0	8	7
55	R:R:I203	R:R:T119	36.3893	6.08	No	No	0	7	7
56	R:R:C207	R:R:I203	35.3222	1.64	No	No	0	8	7
57	R:R:C207	R:R:Y126	34.2496	8.06	No	Yes	0	8	7
58	R:R:I211	R:R:Y126	18.7749	3.63	No	Yes	0	8	7
59	L:L:?1	R:R:F180	21.9735	8.88	Yes	Yes	1	0	3
60	R:R:F180	R:R:F276	14.2841	7.5	Yes	Yes	1	3	4
61	R:R:F276	R:R:L280	14.2183	6.09	Yes	No	1	4	5
62	L:L:?1	R:R:L280	15.376	5.05	Yes	No	1	0	5
63	R:R:D273	R:R:I182	15.8286	5.6	No	Yes	0	4	3
64	R:R:F276	R:R:R251	16.9972	13.9	Yes	Yes	1	4	5
65	R:R:P299	R:R:S298	18.9504	3.56	No	No	0	5	8
66	R:R:R63	R:R:S298	21.0765	2.64	Yes	No	0	7	8
67	L:L:?1	R:R:F277	21.6855	4.44	Yes	No	1	0	5
68	R:R:F244	R:R:I115	20.3906	6.28	Yes	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R22	R:R:W91	6	0	Yes	No	3	4	2	1
R:R:I26	R:R:L30	5.71	1	No	No	5	5	2	2
R:R:I26	R:R:Y87	4.84	1	No	Yes	5	6	2	1
R:R:L30	R:R:Y87	11.72	1	No	Yes	5	6	2	1
R:R:E37	R:R:L80	3.98	1	Yes	No	7	8	2	2
R:R:E37	R:R:Y284	8.98	1	Yes	Yes	7	7	2	1
R:R:C79	R:R:L107	4.76	0	No	No	6	6	2	1
R:R:L80	R:R:Y284	7.03	1	No	Yes	8	7	2	1
R:R:L83	R:R:Y87	7.03	1	No	Yes	6	6	1	1
R:R:L107	R:R:L83	4.15	1	No	No	6	6	1	1
L:L:?1	R:R:L83	3.78	1	Yes	No	0	6	0	1
R:R:N86	R:R:W93	9.04	0	No	Yes	5	9	1	2
L:L:?1	R:R:N86	3.75	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y87	9.61	1	Yes	Yes	0	6	0	1
R:R:F277	R:R:W91	11.02	1	No	No	5	4	1	1
L:L:?1	R:R:W91	6.23	1	Yes	No	0	4	0	1
L:L:?1	R:R:L104	3.78	1	Yes	No	0	5	0	1
L:L:?1	R:R:L107	10.09	1	Yes	No	0	6	0	1
R:R:E196	R:R:R111	6.98	0	No	Yes	5	8	2	1
R:R:R111	R:R:T283	3.88	1	Yes	No	8	8	1	2
R:R:R111	R:R:Y284	4.12	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:R111	9.96	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S178	5.47	1	Yes	No	0	4	0	1
R:R:H189	R:R:S179	5.58	0	Yes	No	5	4	2	1
L:L:?1	R:R:S179	6.84	1	Yes	No	0	4	0	1
R:R:F180	R:R:H189	12.44	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F193	9.65	1	Yes	No	3	6	1	2
R:R:F180	R:R:F276	7.5	1	Yes	Yes	3	4	1	2
R:R:F180	R:R:L280	3.65	1	Yes	No	3	5	1	1
L:L:?1	R:R:F180	8.88	1	Yes	Yes	0	3	0	1
R:R:F193	R:R:F276	4.29	1	No	Yes	6	4	2	2
R:R:D273	R:R:F277	7.17	0	No	No	4	5	2	1
R:R:F276	R:R:L280	6.09	1	Yes	No	4	5	2	1
L:L:?1	R:R:F277	4.44	1	Yes	No	0	5	0	1
L:L:?1	R:R:L280	5.05	1	Yes	No	0	5	0	1
R:R:T283	R:R:Y284	4.99	1	No	Yes	8	7	2	1
L:L:?1	R:R:Y284	6.41	1	Yes	Yes	0	7	0	1
R:R:S178	R:R:S181	3.26	0	No	No	4	4	1	2
R:R:L104	R:R:M167	2.83	0	No	No	5	3	1	2
R:R:P31	R:R:Y87	2.78	0	Yes	Yes	6	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IHH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	273
Number of Links	311
Number of Hubs	40
Number of Links mediated by Hubs	157
Number of Communities	12
Number of Nodes involved in Communities	75
Number of Links involved in Communities	97

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	68793
Length Of Smallest Path	3
Average Path Length	13.4248
Length of Longest Path	27
Minimum Path Strength	1.515
Average Path Strength	6.02526
Maximum Path Strength	22.685
Minimum Path Correlation	0.7
Average Path Correlation	0.917146
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	45.3318
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.1212
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	P8A
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P8A
Name	5-butyl-1~{H}-pyrazole-3-carboxylic acid
Synonyms
Identifier
Formula	C8 H12 N2 O2
Molecular Weight	168.193
SMILES
PubChem	6485181
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	0
Total Bonds	24
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8IHH_nogp_Chain_R H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	To be published
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	To be published
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	To be published
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	To be published

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