psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L80	5.61	Yes	Yes	1	0	6
2	L:L:?1	R:R:Y84	3.8	Yes	Yes	1	0	5
3	L:L:?1	R:R:W88	5.54	Yes	Yes	1	0	4
4	L:L:?1	R:R:L101	7.85	Yes	No	0	0	6
5	L:L:?1	R:R:L104	13.46	Yes	No	0	0	6
6	L:L:?1	R:R:K108	8	Yes	No	0	0	8
7	L:L:?1	R:R:S175	7.3	Yes	No	0	0	3
8	L:L:?1	R:R:S176	9.73	Yes	No	1	0	6
9	L:L:?1	R:R:F177	15.79	Yes	Yes	1	0	4
10	L:L:?1	R:R:F274	4.94	Yes	Yes	1	0	5
11	L:L:?1	R:R:L277	4.49	Yes	No	1	0	5
12	L:L:?1	R:R:Y281	10.45	Yes	Yes	1	0	7
13	R:R:H6	R:R:S4	11.16	No	No	0	6	5
14	R:R:F18	R:R:H6	15.84	Yes	No	0	3	6
15	R:R:F7	R:R:N14	7.25	Yes	No	0	8	7
16	R:R:I10	R:R:L8	4.28	Yes	No	6	4	6
17	R:R:L8	R:R:T166	4.42	No	No	6	6	2
18	R:R:I10	R:R:N11	4.25	Yes	No	0	4	7
19	R:R:C15	R:R:I10	6.55	No	Yes	0	9	4
20	R:R:I10	R:R:T166	7.6	Yes	No	6	4	2
21	R:R:N11	R:R:N163	4.09	No	No	0	7	5
22	R:R:K13	R:R:N182	16.79	No	No	0	5	3
23	R:R:C15	R:R:C180	7.28	No	No	0	9	1
24	R:R:C16	R:R:F18	4.19	No	Yes	0	2	3
25	R:R:C16	R:R:C263	7.28	No	No	0	2	7
26	R:R:L173	R:R:V17	5.96	No	No	0	2	5
27	R:R:F18	R:R:S267	9.25	Yes	No	0	3	3
28	R:R:D270	R:R:F18	7.17	No	Yes	0	4	3
29	R:R:N87	R:R:R19	13.26	No	Yes	0	5	4
30	R:R:R19	R:R:W88	5	Yes	Yes	0	4	4
31	R:R:E170	R:R:R19	6.98	No	Yes	0	5	4
32	R:R:A171	R:R:R19	5.53	No	Yes	0	3	4
33	R:R:D20	R:R:N22	12.12	No	No	0	5	2
34	R:R:E21	R:R:N87	13.15	No	No	0	3	5
35	R:R:I23	R:R:L27	5.71	Yes	No	1	4	6
36	R:R:I23	R:R:Y84	4.84	Yes	Yes	1	4	5
37	R:R:I23	R:R:W88	7.05	Yes	Yes	1	4	4
38	R:R:L27	R:R:Y84	12.89	No	Yes	1	6	5
39	R:R:P28	R:R:P29	5.84	No	No	0	6	4
40	R:R:E34	R:R:L31	3.98	No	No	0	7	7
41	R:R:L31	R:R:T81	5.9	No	No	0	7	6
42	R:R:F37	R:R:L33	4.87	No	No	0	5	5
43	R:R:E34	R:R:Y281	5.61	No	Yes	0	7	7
44	R:R:E34	R:R:M282	5.41	No	No	0	7	4
45	R:R:F35	R:R:L39	9.74	No	No	0	6	6
46	R:R:F35	R:R:P78	8.67	No	No	0	6	9
47	R:R:F37	R:R:V36	5.24	No	No	0	5	4
48	R:R:F37	R:R:M285	4.98	No	No	0	5	7
49	R:R:F71	R:R:L39	3.65	Yes	No	0	7	6
50	R:R:I74	R:R:L39	5.71	No	No	0	6	6
51	R:R:G41	R:R:P288	4.06	No	No	0	8	9
52	R:R:D70	R:R:N42	6.73	Yes	No	0	9	9
53	R:R:N42	R:R:P288	8.15	No	No	0	9	9
54	R:R:A45	R:R:Y292	5.34	No	Yes	0	8	6
55	R:R:F64	R:R:L46	4.87	Yes	Yes	4	6	7
56	R:R:L46	R:R:V68	4.47	Yes	No	4	7	5
57	R:R:F71	R:R:L46	4.87	Yes	Yes	0	7	7
58	R:R:F49	R:R:S55	7.93	No	No	0	7	5
59	R:R:F49	R:R:F64	32.15	No	Yes	0	7	6
60	R:R:C50	R:R:R60	9.75	No	No	2	3	7
61	R:R:C50	R:R:L63	6.35	No	No	2	3	8
62	R:R:C50	R:R:Y292	5.38	No	Yes	2	3	6
63	R:R:S55	R:R:W56	9.88	No	No	0	5	6
64	R:R:R60	R:R:S59	9.22	No	No	0	7	7
65	R:R:L63	R:R:R60	3.64	No	No	2	8	7
66	R:R:I61	R:R:N138	4.25	No	No	0	6	4
67	R:R:A141	R:R:I61	4.87	No	No	0	7	6
68	R:R:F62	R:R:V117	9.18	No	No	0	7	6
69	R:R:F62	R:R:S145	3.96	No	No	0	7	7
70	R:R:L63	R:R:Y292	11.72	No	Yes	2	8	6
71	R:R:F64	R:R:N65	4.83	Yes	Yes	4	6	9
72	R:R:F64	R:R:V68	6.55	Yes	No	4	6	5
73	R:R:F114	R:R:N65	14.5	No	Yes	4	7	9
74	R:R:N65	R:R:S145	5.96	Yes	No	4	9	7
75	R:R:D70	R:R:L66	5.43	Yes	No	2	9	9
76	R:R:D287	R:R:L66	4.07	Yes	No	2	9	9
77	R:R:L66	R:R:Y292	4.69	No	Yes	2	9	6
78	R:R:A67	R:R:Y292	4	No	Yes	0	8	6
79	R:R:D70	R:R:S111	5.89	Yes	No	0	9	9
80	R:R:D70	R:R:S284	11.78	Yes	No	0	9	8
81	R:R:D287	R:R:D70	6.65	Yes	Yes	2	9	9
82	R:R:F71	R:R:I75	6.28	Yes	No	0	7	4
83	R:R:L72	R:R:M103	5.65	No	No	5	7	4
84	R:R:L72	R:R:N107	8.24	No	No	5	7	8
85	R:R:L73	R:R:N107	4.12	No	No	0	6	8
86	R:R:L73	R:R:S284	6.01	No	No	0	6	8
87	R:R:I74	R:R:I75	4.42	No	No	0	6	4
88	R:R:L77	R:R:Y281	7.03	No	Yes	0	8	7
89	R:R:L80	R:R:Y84	4.69	Yes	Yes	1	6	5
90	R:R:L80	R:R:M100	5.65	Yes	No	0	6	6
91	R:R:L80	R:R:Y281	4.69	Yes	Yes	1	6	7
92	R:R:D82	R:R:H86	8.82	No	No	7	3	4
93	R:R:D82	R:R:R91	14.29	No	No	7	3	3
94	R:R:D82	R:R:F92	4.78	No	No	0	3	7
95	R:R:N83	R:R:W88	4.52	No	Yes	0	5	4
96	R:R:N83	R:R:W90	5.65	No	Yes	0	5	9
97	R:R:W88	R:R:Y84	10.61	Yes	Yes	1	4	5
98	R:R:F274	R:R:Y84	4.13	Yes	Yes	1	5	5
99	R:R:H86	R:R:V85	6.92	No	No	0	4	5
100	R:R:H86	R:R:R91	18.05	No	No	7	4	3
101	R:R:L173	R:R:W88	4.56	No	Yes	0	2	4
102	R:R:F274	R:R:W88	14.03	Yes	Yes	1	5	4
103	R:R:F92	R:R:W90	17.04	No	Yes	0	7	9
104	R:R:C97	R:R:W90	15.67	No	Yes	0	9	9
105	R:R:C174	R:R:C97	7.28	No	No	0	9	9
106	R:R:L104	R:R:M100	5.65	No	No	0	6	6
107	R:R:L101	R:R:M164	7.07	No	No	0	6	4
108	R:R:C174	R:R:L101	4.76	No	No	0	9	6
109	R:R:F102	R:R:M103	3.73	Yes	No	5	5	4
110	R:R:F102	R:R:M106	11.2	Yes	Yes	5	5	5
111	R:R:F102	R:R:T156	6.49	Yes	No	5	5	6
112	R:R:F102	R:R:L159	3.65	Yes	No	0	5	5
113	R:R:F102	R:R:L160	17.05	Yes	No	0	5	4
114	R:R:M103	R:R:N107	7.01	No	No	5	4	8
115	R:R:M106	R:R:T152	4.52	Yes	No	0	5	7
116	R:R:I153	R:R:M106	7.29	Yes	Yes	0	3	5
117	R:R:M106	R:R:T156	7.53	Yes	No	5	5	6
118	R:R:K108	R:R:T280	9.01	No	No	0	8	8
119	R:R:Q109	R:R:T152	8.5	Yes	No	0	7	7
120	R:R:L155	R:R:Q109	10.65	No	Yes	0	5	7
121	R:R:M189	R:R:Q109	12.23	No	Yes	0	5	7
122	R:R:E193	R:R:Q109	17.84	No	Yes	0	6	7
123	R:R:G110	R:R:T152	3.64	No	No	0	7	7
124	R:R:E193	R:R:I112	9.56	No	Yes	0	6	8
125	R:R:F237	R:R:I112	3.77	Yes	Yes	0	9	8
126	R:R:F241	R:R:I112	7.54	Yes	Yes	0	9	8
127	R:R:I113	R:R:L148	5.71	No	No	0	5	6
128	R:R:F114	R:R:S145	5.28	No	No	4	7	7
129	R:R:F114	R:R:W149	8.02	No	No	0	7	9
130	R:R:D287	R:R:L115	5.43	Yes	No	0	9	8
131	R:R:L115	R:R:Y291	8.21	No	Yes	0	8	9
132	R:R:P197	R:R:T116	5.25	No	No	0	9	7
133	R:R:I200	R:R:T116	6.08	No	No	0	6	7
134	R:R:R122	R:R:V118	5.23	No	No	9	9	8
135	R:R:V118	R:R:Y291	3.79	No	Yes	9	8	9
136	R:R:R122	R:R:Y291	7.2	No	Yes	9	9	9
137	R:R:F124	R:R:Y123	5.16	Yes	Yes	3	5	7
138	R:R:V127	R:R:Y123	10.09	Yes	Yes	3	7	7
139	R:R:H128	R:R:Y123	7.62	Yes	Yes	3	6	7
140	R:R:F203	R:R:Y123	4.13	No	Yes	0	4	7
141	R:R:C204	R:R:Y123	8.06	No	Yes	0	6	7
142	R:R:R207	R:R:Y123	7.2	Yes	Yes	3	4	7
143	R:R:I208	R:R:Y123	3.63	No	Yes	0	7	7
144	R:R:F124	R:R:H128	6.79	Yes	Yes	3	5	6
145	R:R:F124	R:R:H131	13.58	Yes	No	3	5	4
146	R:R:F124	R:R:L133	8.53	Yes	No	3	5	4
147	R:R:N134	R:R:R125	7.23	No	No	0	4	8
148	R:R:I208	R:R:V126	9.22	No	No	0	7	8
149	R:R:L212	R:R:V126	4.47	No	No	0	8	8
150	R:R:H128	R:R:V127	6.92	Yes	Yes	3	6	7
151	R:R:R207	R:R:V127	14.38	Yes	Yes	3	4	7
152	R:R:S211	R:R:V127	6.46	No	Yes	3	5	7
153	R:R:H130	R:R:P129	12.2	No	No	0	6	8
154	R:R:H131	R:R:L133	9	No	No	3	4	4
155	R:R:F132	R:R:L133	6.09	No	No	0	5	4
156	R:R:I136	R:R:T140	6.08	No	No	0	6	3
157	R:R:L151	R:R:L155	5.54	No	No	0	4	5
158	R:R:L155	R:R:W185	6.83	No	No	0	5	5
159	R:R:H158	R:R:L159	3.86	No	No	0	8	5
160	R:R:H158	R:R:W185	6.35	No	No	0	8	5
161	R:R:H158	R:R:H186	5.97	No	Yes	0	8	5
162	R:R:L159	R:R:M164	7.07	No	No	0	5	4
163	R:R:M165	R:R:Y172	8.38	No	No	0	4	4
164	R:R:K167	R:R:Y172	8.36	No	No	0	3	4
165	R:R:F177	R:R:S176	7.93	Yes	No	1	4	6
166	R:R:H186	R:R:S176	8.37	Yes	No	1	5	6
167	R:R:F177	R:R:H186	6.79	Yes	Yes	1	4	5
168	R:R:F177	R:R:F273	12.86	Yes	Yes	1	4	4
169	R:R:F177	R:R:L277	4.87	Yes	No	1	4	5
170	R:R:I179	R:R:I251	5.89	Yes	No	0	4	4
171	R:R:I179	R:R:L255	4.28	Yes	No	10	4	3
172	R:R:I179	R:R:Y266	9.67	Yes	Yes	10	4	4
173	R:R:D270	R:R:I179	5.6	No	Yes	0	4	4
174	R:R:N259	R:R:Y181	18.61	No	No	0	1	3
175	R:R:F183	R:R:F252	10.72	No	No	0	3	5
176	R:R:H186	R:R:R184	9.03	Yes	No	0	5	2
177	R:R:D187	R:R:R184	5.96	No	No	0	4	2
178	R:R:M189	R:R:W185	13.96	No	No	0	5	5
179	R:R:D187	R:R:F252	10.75	No	No	0	4	5
180	R:R:F190	R:R:R248	4.28	No	Yes	0	5	6
181	R:R:F195	R:R:L191	3.65	No	No	0	4	4
182	R:R:I249	R:R:L191	5.71	No	No	0	6	4
183	R:R:F194	R:R:F195	7.5	Yes	No	0	8	4
184	R:R:F194	R:R:L198	6.09	Yes	No	8	8	6
185	R:R:F194	R:R:F237	4.29	Yes	Yes	8	8	9
186	R:R:F194	R:R:L242	7.31	Yes	No	0	8	5
187	R:R:F194	R:R:V245	3.93	Yes	No	0	8	8
188	R:R:F237	R:R:L198	6.09	Yes	No	8	9	6
189	R:R:F237	R:R:I201	3.77	Yes	No	0	9	8
190	R:R:R207	R:R:S211	7.91	Yes	No	3	4	5
191	R:R:I209	R:R:R213	6.26	No	No	0	4	4
192	R:R:I209	R:R:I227	10.3	No	No	0	4	5
193	R:R:I209	R:R:I230	5.89	No	No	0	4	7
194	R:R:Q214	R:R:W210	8.76	No	No	0	5	4
195	R:R:I223	R:R:L212	5.71	No	No	0	6	8
196	R:R:I227	R:R:L212	4.28	No	No	0	5	8
197	R:R:H220	R:R:Q216	3.71	No	No	0	3	5
198	R:R:D218	R:R:M217	4.16	No	No	0	3	2
199	R:R:K222	R:R:R219	6.19	No	No	0	5	4
200	R:R:H220	R:R:K224	7.86	No	No	0	3	6
201	R:R:F229	R:R:R225	13.9	No	No	0	7	7
202	R:R:F229	R:R:S294	9.25	No	No	0	7	6
203	R:R:V233	R:R:V290	4.81	No	No	0	8	7
204	R:R:V233	R:R:Y291	10.09	No	Yes	0	8	9
205	R:R:C240	R:R:F241	4.19	Yes	Yes	2	8	9
206	R:R:C240	R:R:N283	7.87	Yes	No	2	8	9
207	R:R:F241	R:R:T280	11.67	Yes	No	0	9	8
208	R:R:F241	R:R:N283	7.25	Yes	No	2	9	9
209	R:R:S244	R:R:T276	7.99	No	No	0	7	6
210	R:R:F273	R:R:V247	3.93	Yes	No	0	4	4
211	R:R:I251	R:R:R248	8.77	No	Yes	0	4	6
212	R:R:F252	R:R:R248	7.48	No	Yes	0	5	6
213	R:R:F273	R:R:R248	13.9	Yes	Yes	0	4	6
214	R:R:R250	R:R:W253	5	No	No	0	5	4
215	R:R:L254	R:R:R250	10.93	No	No	0	2	5
216	R:R:I251	R:R:V269	7.68	No	No	0	4	5
217	R:R:L254	R:R:Y266	7.03	No	Yes	0	2	4
218	R:R:L255	R:R:Y266	8.21	No	Yes	10	3	4
219	R:R:K257	R:R:Y258	16.72	No	No	0	2	1
220	R:R:I265	R:R:Y258	3.63	No	No	0	3	1
221	R:R:C263	R:R:V260	5.12	No	No	0	7	1
222	R:R:V260	R:R:Y266	3.79	No	Yes	0	1	4
223	R:R:D264	R:R:I265	4.2	No	No	0	2	3
224	R:R:I265	R:R:Y266	6.04	No	Yes	0	3	4
225	R:R:D270	R:R:F274	8.36	No	Yes	0	4	5
226	R:R:F273	R:R:F274	5.36	Yes	Yes	1	4	5
227	R:R:F273	R:R:L277	9.74	Yes	No	1	4	5
228	R:R:F279	R:R:S278	3.96	No	No	0	7	4
229	R:R:M282	R:R:M285	5.78	No	No	0	4	7
230	R:R:L286	R:R:M282	4.24	No	No	0	6	4
231	R:R:D287	R:R:N283	12.12	Yes	No	2	9	9
232	R:R:F293	R:R:P288	5.78	No	No	0	7	9
233	R:R:F293	R:R:V289	3.93	No	No	0	7	6
234	R:R:P296	R:R:S295	5.34	No	No	0	5	8
235	R:R:N168	R:R:R19	3.62	No	Yes	0	3	4
236	R:R:N182	R:R:R184	3.62	No	No	0	3	2
237	R:R:P28	R:R:V85	3.53	No	No	0	6	5
238	R:R:G110	R:R:I113	3.53	No	No	0	7	5
239	R:R:P243	R:R:T276	3.5	No	No	0	9	6
240	R:R:M165	R:R:W90	3.49	No	Yes	0	4	9
241	R:R:G94	R:R:M165	3.49	No	No	0	3	4
242	R:R:C15	R:R:S178	3.44	No	No	0	9	4
243	R:R:C204	R:R:V120	3.42	No	No	0	6	6
244	R:R:I95	R:R:P96	3.39	No	No	0	3	5
245	R:R:I112	R:R:P197	3.39	Yes	No	0	8	9
246	R:R:A272	R:R:V247	3.39	No	No	0	5	4
247	R:R:L242	R:R:P243	3.28	No	No	0	5	9
248	R:R:S175	R:R:S178	3.26	No	No	0	3	4
249	R:R:S278	R:R:V30	3.23	No	No	0	4	5
250	R:R:C76	R:R:L104	3.17	No	No	0	6	6
251	R:R:A67	R:R:L46	3.15	No	Yes	0	8	7
252	R:R:I230	R:R:S205	3.1	No	No	0	7	9
253	R:R:A171	R:R:D89	3.09	No	No	0	3	4
254	R:R:I144	R:R:T140	3.04	No	No	0	5	3
255	R:R:A24	R:R:E21	3.02	No	No	0	5	3
256	R:R:F71	R:R:G43	3.01	Yes	No	0	7	3
257	R:R:M164	R:R:T162	3.01	No	No	0	4	4
258	R:R:L27	R:R:S278	3	No	No	0	6	4
259	R:R:R207	R:R:W210	3	Yes	No	0	4	4
260	R:R:L160	R:R:V99	2.98	No	No	0	4	4
261	R:R:N259	R:R:V260	2.96	No	No	0	1	1
262	R:R:L271	R:R:T275	2.95	No	No	0	1	5
263	R:R:I235	R:R:M231	2.92	No	No	0	4	4
264	R:R:F92	R:R:P96	2.89	No	No	0	7	5
265	R:R:I23	R:R:L271	2.85	Yes	No	0	4	1
266	R:R:I144	R:R:L148	2.85	No	No	0	5	6
267	R:R:I238	R:R:L198	2.85	No	No	0	5	6
268	R:R:I238	R:R:L242	2.85	No	No	0	5	5
269	R:R:I61	R:R:N65	2.83	No	Yes	0	6	9
270	R:R:G93	R:R:W90	2.81	No	Yes	0	8	9
271	R:R:C76	R:R:F79	2.79	No	No	0	6	6
272	R:R:A188	R:R:F183	2.77	No	No	0	4	3
273	R:R:F7	R:R:V9	2.62	Yes	No	0	8	7
274	R:R:A69	R:R:W149	2.59	No	No	0	8	9
275	R:R:I95	R:R:R98	2.51	No	No	0	3	7
276	R:R:F132	R:R:I136	2.51	No	No	0	5	6
277	R:R:F132	R:R:K135	2.48	No	No	0	5	4
278	R:R:N262	R:R:R261	2.41	No	No	0	5	2
279	R:R:F7	R:R:R261	2.14	Yes	No	0	8	2
280	R:R:G206	R:R:S205	1.86	No	No	0	3	9
281	R:R:G12	R:R:V9	1.84	No	No	0	4	7
282	R:R:G38	R:R:I74	1.76	No	No	0	8	6
283	R:R:G150	R:R:I153	1.76	No	Yes	0	4	3
284	R:R:G154	R:R:I153	1.76	No	Yes	0	4	3
285	R:R:A141	R:R:S58	1.71	No	No	0	7	7
286	R:R:C240	R:R:V236	1.71	Yes	No	0	8	6
287	R:R:G169	R:R:N168	1.7	No	No	0	3	3
288	R:R:A105	R:R:T156	1.68	No	No	0	5	6
289	R:R:L196	R:R:P197	1.64	No	No	0	5	9
290	R:R:C240	R:R:I239	1.64	Yes	No	0	8	6
291	R:R:A119	R:R:I201	1.62	No	No	0	9	8
292	R:R:S268	R:R:V269	1.62	No	No	0	4	5
293	R:R:S137	R:R:T140	1.6	No	No	0	6	3
294	R:R:V232	R:R:V236	1.6	No	No	0	5	6
295	R:R:V232	R:R:V290	1.6	No	No	0	5	7
296	R:R:T275	R:R:V26	1.59	No	No	0	5	5
297	R:R:A188	R:R:L192	1.58	No	No	0	4	4
298	R:R:A234	R:R:L202	1.58	No	No	0	7	5
299	R:R:I153	R:R:V157	1.54	Yes	No	0	3	3
300	R:R:K57	R:R:S59	1.53	No	No	0	7	7
301	R:R:H128	R:R:P129	1.53	Yes	No	0	6	8
302	R:R:K25	R:R:V26	1.52	No	No	0	2	5
303	R:R:I235	R:R:I239	1.47	No	No	0	4	6
304	R:R:I238	R:R:L202	1.43	No	No	0	5	5
305	R:R:K135	R:R:N134	1.4	No	No	0	4	4
306	R:R:D20	R:R:L271	1.36	No	No	0	5	1
307	R:R:R139	R:R:S137	1.32	No	No	0	4	6
308	R:R:I143	R:R:R139	1.25	No	No	0	3	4
309	R:R:D5	R:R:F7	1.19	No	Yes	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.08	12	1	0
2	R:R:F7	3.3	4	0	8
3	R:R:I10	5.67	4	6	4
4	R:R:F18	9.1125	4	0	3
5	R:R:R19	6.878	5	0	4
6	R:R:I23	5.1125	4	1	4
7	R:R:L46	4.34	4	4	7
8	R:R:F64	12.1	4	4	6
9	R:R:N65	7.03	4	4	9
10	R:R:D70	7.296	5	2	9
11	R:R:F71	4.4525	4	0	7
12	R:R:L80	5.16	4	1	6
13	R:R:Y84	6.82667	6	1	5
14	R:R:W88	7.33	7	1	4
15	R:R:W90	8.932	5	0	9
16	R:R:F102	8.424	5	5	5
17	R:R:M106	7.635	4	5	5
18	R:R:Q109	12.305	4	0	7
19	R:R:I112	6.065	4	0	8
20	R:R:Y123	6.55571	7	3	7
21	R:R:F124	8.515	4	3	5
22	R:R:V127	9.4625	4	3	7
23	R:R:H128	5.715	4	3	6
24	R:R:I153	3.0875	4	0	3
25	R:R:F177	9.648	5	1	4
26	R:R:I179	6.36	4	10	4
27	R:R:H186	7.54	4	1	5
28	R:R:F194	5.824	5	8	8
29	R:R:R207	8.1225	4	3	4
30	R:R:F237	4.48	4	8	9
31	R:R:C240	3.8525	4	2	8
32	R:R:F241	7.6625	4	2	9
33	R:R:R248	8.6075	4	0	6
34	R:R:Y266	6.948	5	10	4
35	R:R:F273	9.158	5	1	4
36	R:R:F274	7.364	5	1	5
37	R:R:Y281	6.945	4	1	7
38	R:R:D287	7.0675	4	2	9
39	R:R:Y291	7.3225	4	9	9
40	R:R:Y292	6.226	5	2	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F274	43.8823	4.94	Yes	Yes	1	0	5
2	R:R:D270	R:R:F274	43.1542	8.36	No	Yes	0	4	5
3	R:R:D270	R:R:F18	12.9185	7.17	No	Yes	0	4	3
4	L:L:?1	R:R:S175	20.0871	7.3	Yes	No	0	0	3
5	R:R:S175	R:R:S178	18.0453	3.26	No	No	0	3	4
6	R:R:C15	R:R:S178	16.0111	3.44	No	No	0	9	4
7	R:R:C15	R:R:I10	11.5073	6.55	No	Yes	0	9	4
8	L:L:?1	R:R:S176	12.5882	9.73	Yes	No	1	0	6
9	R:R:H186	R:R:S176	12.378	8.37	Yes	No	1	5	6
10	R:R:H186	R:R:R184	20.8752	9.03	Yes	No	0	5	2
11	L:L:?1	R:R:F177	23.1121	15.79	Yes	Yes	1	0	4
12	R:R:F177	R:R:H186	24.756	6.79	Yes	Yes	1	4	5
13	L:L:?1	R:R:W88	46.8098	5.54	Yes	Yes	1	0	4
14	R:R:R19	R:R:W88	18.4657	5	Yes	Yes	0	4	4
15	L:L:?1	R:R:Y84	17.8727	3.8	Yes	Yes	1	0	5
16	R:R:I23	R:R:Y84	13.1812	4.84	Yes	Yes	1	4	5
17	R:R:I23	R:R:L271	23.5475	2.85	Yes	No	0	4	1
18	R:R:I23	R:R:W88	14.9002	7.05	Yes	Yes	1	4	4
19	R:R:N83	R:R:W88	27.5935	4.52	No	Yes	0	5	4
20	R:R:N83	R:R:W90	25.7094	5.65	No	Yes	0	5	9
21	R:R:F92	R:R:W90	21.5358	17.04	No	Yes	0	7	9
22	R:R:D82	R:R:F92	13.0986	4.78	No	No	0	3	7
23	L:L:?1	R:R:Y281	24.5984	10.45	Yes	Yes	1	0	7
24	R:R:E34	R:R:Y281	21.2055	5.61	No	Yes	0	7	7
25	R:R:E34	R:R:M282	14.2696	5.41	No	No	0	7	4
26	L:L:?1	R:R:K108	100	8	Yes	No	0	0	8
27	R:R:K108	R:R:T280	99.8574	9.01	No	No	0	8	8
28	R:R:F241	R:R:T280	99.6847	11.67	Yes	No	0	9	8
29	R:R:F241	R:R:N283	91.3752	7.25	Yes	No	2	9	9
30	R:R:D287	R:R:N283	92.4861	12.12	Yes	No	2	9	9
31	R:R:D287	R:R:L66	69.9445	4.07	Yes	No	2	9	9
32	R:R:L66	R:R:Y292	75.8219	4.69	No	Yes	2	9	6
33	R:R:A67	R:R:Y292	58.0619	4	No	Yes	0	8	6
34	R:R:A67	R:R:L46	56.1928	3.15	No	Yes	0	8	7
35	R:R:F71	R:R:L46	22.1363	4.87	Yes	Yes	0	7	7
36	R:R:F71	R:R:L39	11.162	3.65	Yes	No	0	7	6
37	R:R:D287	R:R:D70	15.1554	6.65	Yes	Yes	2	9	9
38	R:R:D70	R:R:N42	12.9785	6.73	Yes	No	0	9	9
39	R:R:N42	R:R:P288	10.4113	8.15	No	No	0	9	9
40	R:R:F64	R:R:L46	32.39	4.87	Yes	Yes	4	6	7
41	R:R:F64	R:R:N65	24.1255	4.83	Yes	Yes	4	6	9
42	R:R:D70	R:R:S284	11.7175	11.78	Yes	No	0	9	8
43	L:L:?1	R:R:L101	41.9607	7.85	Yes	No	0	0	6
44	R:R:L101	R:R:M164	47.11	7.07	No	No	0	6	4
45	R:R:L159	R:R:M164	45.7739	7.07	No	No	0	5	4
46	R:R:F102	R:R:L159	54.4813	3.65	Yes	No	0	5	5
47	R:R:F102	R:R:M103	14.7575	3.73	Yes	No	5	5	4
48	R:R:M103	R:R:N107	12.1078	7.01	No	No	5	4	8
49	R:R:L73	R:R:N107	11.6649	4.12	No	No	0	6	8
50	R:R:C174	R:R:L101	12.2054	4.76	No	No	0	9	6
51	R:R:C174	R:R:C97	10.3663	7.28	No	No	0	9	9
52	R:R:F102	R:R:M106	52.0793	11.2	Yes	Yes	5	5	5
53	R:R:M106	R:R:T152	49.5346	4.52	Yes	No	0	5	7
54	R:R:F241	R:R:I112	60.9893	7.54	Yes	Yes	0	9	8
55	R:R:E193	R:R:I112	38.5378	9.56	No	Yes	0	6	8
56	R:R:E193	R:R:Q109	37.7496	17.84	No	Yes	0	6	7
57	R:R:H158	R:R:H186	36.1808	5.97	No	Yes	0	8	5
58	R:R:H158	R:R:W185	28.2915	6.35	No	No	0	8	5
59	R:R:L155	R:R:W185	15.0803	6.83	No	No	0	5	5
60	R:R:L155	R:R:Q109	13.0611	10.65	No	Yes	0	5	7
61	R:R:M189	R:R:W185	12.9935	13.96	No	No	0	5	5
62	R:R:M189	R:R:Q109	11.9802	12.23	No	Yes	0	5	7
63	R:R:G110	R:R:T152	85.6403	3.64	No	No	0	7	7
64	R:R:F237	R:R:I112	36.0982	3.77	Yes	Yes	0	9	8
65	R:R:G110	R:R:I113	83.8313	3.53	No	No	0	7	5
66	R:R:I113	R:R:L148	82.0072	5.71	No	No	0	5	6
67	R:R:D287	R:R:L115	11.6124	5.43	Yes	No	0	9	8
68	R:R:I144	R:R:L148	80.1681	2.85	No	No	0	5	6
69	R:R:I144	R:R:T140	78.3141	3.04	No	No	0	5	3
70	R:R:I136	R:R:T140	70.7476	6.08	No	No	0	6	3
71	R:R:F132	R:R:I136	68.8185	2.51	No	No	0	5	6
72	R:R:F132	R:R:L133	60.9518	6.09	No	No	0	5	4
73	R:R:F124	R:R:L133	56.7332	8.53	Yes	No	3	5	4
74	R:R:F124	R:R:Y123	43.9273	5.16	Yes	Yes	3	5	7
75	R:R:F124	R:R:H128	10.9593	6.79	Yes	Yes	3	5	6
76	R:R:I208	R:R:Y123	22.9545	3.63	No	Yes	0	7	7
77	R:R:I208	R:R:V126	20.6951	9.22	No	No	0	7	8
78	R:R:L212	R:R:V126	18.4056	4.47	No	No	0	8	8
79	R:R:F273	R:R:F274	18.0453	5.36	Yes	Yes	1	4	5
80	L:L:?1	R:R:L277	12.4981	4.49	Yes	No	1	0	5
81	R:R:F273	R:R:L277	11.0044	9.74	Yes	No	1	4	5
82	R:R:F177	R:R:F273	22.2264	12.86	Yes	Yes	1	4	4
83	R:R:F273	R:R:R248	35.3475	13.9	Yes	Yes	0	4	6
84	R:R:I251	R:R:R248	15.6058	8.77	No	Yes	0	4	6
85	R:R:D270	R:R:I179	29.9204	5.6	No	Yes	0	4	4
86	R:R:I179	R:R:Y266	24.2006	9.67	Yes	Yes	10	4	4
87	R:R:F252	R:R:R248	14.2096	7.48	No	Yes	0	5	6
88	R:R:F183	R:R:F252	13.4965	10.72	No	No	0	3	5
89	R:R:F194	R:R:F237	20.4324	4.29	Yes	Yes	8	8	9
90	R:R:I227	R:R:L212	13.9544	4.28	No	No	0	5	8
91	R:R:I209	R:R:I227	11.8	10.3	No	No	0	4	5
92	R:R:C240	R:R:F241	14.4198	4.19	Yes	Yes	2	8	9
93	R:R:I251	R:R:V269	11.5373	7.68	No	No	0	4	5
94	R:R:L271	R:R:T275	11.8376	2.95	No	No	0	1	5
95	R:R:F274	R:R:W88	10.1186	14.03	Yes	Yes	1	5	4
96	R:R:L73	R:R:S284	10.8993	6.01	No	No	0	6	8
97	R:R:Q109	R:R:T152	45.939	8.5	Yes	No	0	7	7
98	R:R:H158	R:R:L159	11.5748	3.86	No	No	0	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L80	5.61	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y84	3.8	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W88	5.54	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L101	7.85	1	Yes	No	0	6	0	1
L:L:?1	R:R:L104	13.46	1	Yes	No	0	6	0	1
L:L:?1	R:R:K108	8	1	Yes	No	0	8	0	1
L:L:?1	R:R:S175	7.3	1	Yes	No	0	3	0	1
L:L:?1	R:R:S176	9.73	1	Yes	No	0	6	0	1
L:L:?1	R:R:F177	15.79	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F274	4.94	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L277	4.49	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y281	10.45	1	Yes	Yes	0	7	0	1
R:R:R19	R:R:W88	5	0	Yes	Yes	4	4	2	1
R:R:I23	R:R:L27	5.71	1	Yes	No	4	6	2	2
R:R:I23	R:R:Y84	4.84	1	Yes	Yes	4	5	2	1
R:R:I23	R:R:W88	7.05	1	Yes	Yes	4	4	2	1
R:R:L27	R:R:Y84	12.89	1	No	Yes	6	5	2	1
R:R:E34	R:R:Y281	5.61	0	No	Yes	7	7	2	1
R:R:L77	R:R:Y281	7.03	0	No	Yes	8	7	2	1
R:R:L80	R:R:Y84	4.69	1	Yes	Yes	6	5	1	1
R:R:L80	R:R:M100	5.65	1	Yes	No	6	6	1	2
R:R:L80	R:R:Y281	4.69	1	Yes	Yes	6	7	1	1
R:R:N83	R:R:W88	4.52	0	No	Yes	5	4	2	1
R:R:W88	R:R:Y84	10.61	1	Yes	Yes	4	5	1	1
R:R:F274	R:R:Y84	4.13	1	Yes	Yes	5	5	1	1
R:R:L173	R:R:W88	4.56	0	No	Yes	2	4	2	1
R:R:F274	R:R:W88	14.03	1	Yes	Yes	5	4	1	1
R:R:L104	R:R:M100	5.65	0	No	No	6	6	1	2
R:R:L101	R:R:M164	7.07	0	No	No	6	4	1	2
R:R:C174	R:R:L101	4.76	0	No	No	9	6	2	1
R:R:K108	R:R:T280	9.01	0	No	No	8	8	1	2
R:R:F177	R:R:S176	7.93	1	Yes	No	4	6	1	1
R:R:H186	R:R:S176	8.37	1	Yes	No	5	6	2	1
R:R:F177	R:R:H186	6.79	1	Yes	Yes	4	5	1	2
R:R:F177	R:R:F273	12.86	1	Yes	Yes	4	4	1	2
R:R:F177	R:R:L277	4.87	1	Yes	No	4	5	1	1
R:R:D270	R:R:F274	8.36	0	No	Yes	4	5	2	1
R:R:F273	R:R:F274	5.36	1	Yes	Yes	4	5	2	1
R:R:F273	R:R:L277	9.74	1	Yes	No	4	5	2	1
R:R:S175	R:R:S178	3.26	0	No	No	3	4	1	2
R:R:C76	R:R:L104	3.17	0	No	No	6	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8UUJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	273
Number of Links	309
Number of Hubs	40
Number of Links mediated by Hubs	150
Number of Communities	10
Number of Nodes involved in Communities	58
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	99
Number Of Links MetaPath	98
Number of Shortest Paths	44367
Length Of Smallest Path	3
Average Path Length	13.0742
Length of Longest Path	34
Minimum Path Strength	1.285
Average Path Strength	6.76979
Maximum Path Strength	20.04
Minimum Path Correlation	0.7
Average Path Correlation	0.918164
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	51.1619
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.9347
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • purinergic nucleotide receptor activity • nucleotide receptor activity • G protein-coupled receptor activity • nicotinic acid receptor activity • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • multicellular organismal process • regulation of cellular process • homeostatic process • leukocyte apoptotic process • positive regulation of biological process • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • myeloid cell homeostasis • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • positive regulation of cellular process • regulation of leukocyte apoptotic process • myeloid cell apoptotic process • regulation of biological process • positive regulation of programmed cell death • regulation of apoptotic process • biological regulation • cell death • positive regulation of apoptotic process • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • cellular process • homeostasis of number of cells • apoptotic process • programmed cell death • regulation of myeloid cell apoptotic process • cellular response to stimulus • response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • protein localization • positive regulation of cell communication • regulation of localization • establishment of protein localization • system process • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • cellular macromolecule localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • cellular localization • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • regulation of cellular localization • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • protein binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	XI9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	XI9
Name	(3M,4aR,5aR)-3-(1H-tetrazol-5-yl)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole
Synonyms
Identifier
Formula	C8 H8 N6
Molecular Weight	188.189
SMILES
PubChem	58708479
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	2
Total Bonds	25
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9EP66
Sequence	>8UUJ_nogp_Chain_R S D H F L V I N G K N C C V F R D E N I A K V L P P V L G L E F V F G L L G N G L A L W I F C S W K S S R I F L F N L A V A D F L L I I C L P F L T D N Y V H N W D W R F G G I P C R V M L F M L A M N Q G S I I F L T V V A V R Y F R V V H P H H F L N K I S N R T A A I I S C F L W G L T I G L T V H L L Y T N M M T K N G E A Y L C S S F S I C Y N F R W H D A M F L L E F F L P L A I I L F C S G R I I W S L R Q R Q M D R H A K I K R A I N F I M V V A I V F I I C F L P S V A V R I R I F W L L Y K Y N V R N C D I Y S S V D L A F F T T L S F T Y M N S M L D P V V Y Y F S S P S K A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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