psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	6.42	Yes	No	1	0	6
2	L:L:?1	R:R:Y87	4.35	Yes	Yes	1	0	6
3	L:L:?1	R:R:L107	6.42	Yes	No	0	0	6
4	L:L:?1	R:R:R111	9.01	Yes	Yes	1	0	8
5	L:L:?1	R:R:S178	8.35	Yes	No	0	0	4
6	L:L:?1	R:R:S179	2.78	Yes	No	0	0	4
7	L:L:?1	R:R:F180	9.03	Yes	Yes	1	0	3
8	L:L:?1	R:R:Y284	6.52	Yes	Yes	1	0	7
9	R:R:F10	R:R:F21	10.72	No	Yes	3	7	2
10	R:R:F10	R:R:R270	3.21	No	Yes	3	7	1
11	R:R:I13	R:R:L11	2.85	No	No	0	3	8
12	R:R:D14	R:R:E12	7.8	No	No	0	5	5
13	R:R:E12	R:R:V20	9.98	No	No	0	5	2
14	R:R:E12	R:R:N171	9.2	No	No	0	5	1
15	R:R:I13	R:R:N17	4.25	No	No	0	3	5
16	R:R:D14	R:R:I169	12.59	No	No	0	5	1
17	R:R:C18	R:R:K16	3.23	No	No	6	9	4
18	R:R:C183	R:R:K16	6.47	Yes	No	6	1	4
19	R:R:K16	R:R:T185	10.51	No	No	0	4	2
20	R:R:C18	R:R:C183	7.28	No	Yes	6	9	1
21	R:R:C19	R:R:F21	4.19	No	Yes	3	4	2
22	R:R:C19	R:R:C266	7.28	No	No	3	4	7
23	R:R:C266	R:R:F21	4.19	No	Yes	3	7	2
24	R:R:F21	R:R:R270	5.34	Yes	Yes	3	2	1
25	R:R:R22	R:R:R90	14.93	No	No	0	3	4
26	R:R:A174	R:R:R22	4.15	No	No	0	2	3
27	R:R:D23	R:R:R270	10.72	No	Yes	0	4	1
28	R:R:D23	R:R:L274	2.71	No	No	0	4	1
29	R:R:I26	R:R:L30	7.14	No	Yes	1	5	5
30	R:R:I26	R:R:Y87	6.04	No	Yes	1	5	6
31	R:R:I26	R:R:L274	2.85	No	No	0	5	1
32	R:R:I278	R:R:V29	3.07	No	No	0	6	5
33	R:R:L30	R:R:Y87	7.03	Yes	Yes	1	5	6
34	R:R:I278	R:R:L30	2.85	No	Yes	0	6	5
35	R:R:L30	R:R:S281	3	Yes	Yes	1	5	6
36	R:R:P31	R:R:P32	7.79	No	No	0	6	5
37	R:R:E37	R:R:V33	4.28	Yes	No	1	7	5
38	R:R:S281	R:R:V33	4.85	Yes	No	1	6	5
39	R:R:E37	R:R:S281	4.31	Yes	Yes	1	7	6
40	R:R:E37	R:R:Y284	4.49	Yes	Yes	1	7	7
41	R:R:E37	R:R:M285	2.71	Yes	No	0	7	5
42	R:R:F38	R:R:P81	7.22	No	No	0	7	8
43	R:R:F40	R:R:M288	6.22	No	No	0	6	8
44	R:R:I77	R:R:L42	2.85	No	No	0	6	7
45	R:R:D73	R:R:N45	14.81	No	No	0	9	9
46	R:R:N45	R:R:P291	6.52	No	No	0	9	9
47	R:R:I51	R:R:L47	5.71	No	No	0	7	6
48	R:R:F67	R:R:L49	4.87	No	No	0	6	7
49	R:R:F54	R:R:W50	8.02	No	No	0	4	4
50	R:R:H55	R:R:W50	7.41	No	No	0	5	4
51	R:R:F52	R:R:F67	7.5	No	No	0	7	6
52	R:R:F52	R:R:Y295	3.09	No	Yes	0	7	7
53	R:R:C53	R:R:F54	4.19	No	No	0	4	4
54	R:R:I64	R:R:W59	3.52	Yes	No	0	7	6
55	R:R:F67	R:R:W59	3.01	No	No	0	6	6
56	R:R:I139	R:R:S61	6.19	No	No	0	7	6
57	R:R:A144	R:R:S61	3.42	No	No	0	7	6
58	R:R:D124	R:R:S62	7.36	No	No	0	8	8
59	R:R:A144	R:R:I64	3.25	No	Yes	0	7	7
60	R:R:F65	R:R:V120	7.87	No	No	0	7	7
61	R:R:L66	R:R:V121	2.98	No	No	0	8	9
62	R:R:L66	R:R:Y295	5.86	No	Yes	0	8	7
63	R:R:F117	R:R:N68	14.5	No	No	7	8	9
64	R:R:N68	R:R:S148	8.94	No	No	0	9	8
65	R:R:N68	R:R:W152	6.78	No	No	7	9	9
66	R:R:L69	R:R:S114	3	No	No	0	9	9
67	R:R:D290	R:R:L69	6.79	No	No	0	9	9
68	R:R:L69	R:R:Y295	3.52	No	Yes	0	9	7
69	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
70	R:R:D73	R:R:S287	2.94	No	No	0	9	8
71	R:R:F74	R:R:I78	7.54	No	No	0	7	6
72	R:R:L75	R:R:N110	8.24	No	Yes	0	6	9
73	R:R:L107	R:R:L76	2.77	No	No	0	6	7
74	R:R:L76	R:R:N110	6.87	No	Yes	0	7	9
75	R:R:L76	R:R:S287	3	No	No	0	7	8
76	R:R:C79	R:R:M106	4.86	No	No	0	6	5
77	R:R:L80	R:R:Y284	3.52	No	Yes	0	8	7
78	R:R:F82	R:R:W93	4.01	No	Yes	2	6	9
79	R:R:F82	R:R:F95	5.36	No	Yes	2	6	7
80	R:R:L83	R:R:Y87	9.38	No	Yes	1	6	6
81	R:R:L83	R:R:M103	5.65	No	No	0	6	5
82	R:R:D85	R:R:K94	2.77	No	No	0	4	3
83	R:R:N86	R:R:W91	5.65	No	Yes	0	5	4
84	R:R:N86	R:R:W93	3.39	No	Yes	0	5	9
85	R:R:W91	R:R:Y87	7.72	Yes	Yes	0	4	6
86	R:R:K94	R:R:R89	12.38	No	No	0	3	4
87	R:R:S178	R:R:W91	4.94	No	Yes	0	4	4
88	R:R:F277	R:R:W91	7.02	No	Yes	0	5	4
89	R:R:A174	R:R:D92	3.09	No	No	0	2	4
90	R:R:F95	R:R:W93	10.02	Yes	Yes	2	7	9
91	R:R:C100	R:R:W93	6.53	Yes	Yes	2	9	9
92	R:R:M103	R:R:W93	3.49	No	Yes	0	5	9
93	R:R:F95	R:R:K94	9.93	Yes	No	0	7	3
94	R:R:F95	R:R:P99	2.89	Yes	No	0	7	5
95	R:R:D97	R:R:R101	10.72	No	No	0	3	6
96	R:R:D97	R:R:P168	12.88	No	No	0	3	4
97	R:R:I98	R:R:P99	3.39	No	No	0	2	5
98	R:R:I98	R:R:R101	5.01	No	No	0	2	6
99	R:R:C100	R:R:M167	3.24	Yes	No	2	9	3
100	R:R:C100	R:R:P168	5.65	Yes	No	2	9	4
101	R:R:C100	R:R:C177	7.28	Yes	No	0	9	9
102	R:R:L104	R:R:M167	4.24	No	No	0	5	3
103	R:R:C177	R:R:L104	4.76	No	No	0	9	5
104	R:R:F105	R:R:M109	7.46	Yes	Yes	4	6	5
105	R:R:F105	R:R:T159	5.19	Yes	No	4	6	7
106	R:R:F105	R:R:L163	9.74	Yes	No	0	6	5
107	R:R:M106	R:R:M109	2.89	No	Yes	4	5	5
108	R:R:M106	R:R:N110	2.8	No	Yes	4	5	9
109	R:R:A108	R:R:H189	2.93	No	Yes	0	4	5
110	R:R:M109	R:R:N110	2.8	Yes	Yes	4	5	9
111	R:R:I156	R:R:M109	4.37	No	Yes	0	4	5
112	R:R:M109	R:R:T159	4.52	Yes	No	4	5	7
113	R:R:E196	R:R:R111	3.49	No	Yes	0	5	8
114	R:R:R111	R:R:T283	3.88	Yes	No	0	8	8
115	R:R:R111	R:R:Y284	3.09	Yes	Yes	1	8	7
116	R:R:M192	R:R:Q112	6.8	No	No	0	5	7
117	R:R:G113	R:R:T155	5.46	No	No	0	7	7
118	R:R:E196	R:R:I115	6.83	No	No	0	5	8
119	R:R:I115	R:R:P200	3.39	No	No	0	8	9
120	R:R:F244	R:R:I115	6.28	Yes	No	0	8	8
121	R:R:I116	R:R:L151	5.71	No	No	0	5	7
122	R:R:I116	R:R:T155	4.56	No	No	0	5	7
123	R:R:F117	R:R:L151	4.87	No	No	0	8	7
124	R:R:F117	R:R:W152	7.02	No	No	7	8	9
125	R:R:D290	R:R:L118	2.71	No	No	0	9	9
126	R:R:P200	R:R:T119	3.5	No	No	0	9	7
127	R:R:I203	R:R:T119	4.56	No	No	0	7	7
128	R:R:I204	R:R:T119	3.04	Yes	No	0	8	7
129	R:R:R125	R:R:V121	5.23	No	No	0	9	9
130	R:R:D124	R:R:R128	5.96	No	No	0	8	8
131	R:R:R125	R:R:Y294	4.12	No	Yes	0	9	9
132	R:R:V130	R:R:Y126	12.62	No	Yes	5	8	7
133	R:R:H131	R:R:Y126	5.44	Yes	Yes	5	7	7
134	R:R:F206	R:R:Y126	4.13	No	Yes	5	4	7
135	R:R:C207	R:R:Y126	8.06	No	Yes	0	8	7
136	R:R:R210	R:R:Y126	5.14	No	Yes	5	4	7
137	R:R:I211	R:R:Y126	3.63	No	Yes	0	8	7
138	R:R:F127	R:R:H131	4.53	No	Yes	0	5	7
139	R:R:F127	R:R:L136	3.65	No	No	0	5	4
140	R:R:N137	R:R:R128	7.23	No	No	0	4	8
141	R:R:I211	R:R:V129	6.14	No	No	0	8	8
142	R:R:H131	R:R:V130	9.69	Yes	No	5	7	8
143	R:R:S214	R:R:V130	6.46	No	No	0	5	8
144	R:R:H134	R:R:N137	3.83	No	No	0	4	4
145	R:R:S140	R:R:T143	4.8	No	No	0	6	3
146	R:R:L158	R:R:W188	5.69	No	No	0	5	5
147	R:R:H161	R:R:L162	6.43	No	No	0	7	4
148	R:R:H161	R:R:W188	3.17	No	No	0	7	5
149	R:R:M167	R:R:P168	5.03	No	No	2	3	4
150	R:R:N175	R:R:Q170	10.56	No	No	0	4	1
151	R:R:L176	R:R:N171	4.12	No	No	0	4	1
152	R:R:H189	R:R:S179	8.37	Yes	No	0	5	4
153	R:R:F180	R:R:H189	6.79	Yes	Yes	0	3	5
154	R:R:E190	R:R:F180	7	Yes	Yes	1	4	3
155	R:R:F180	R:R:F193	3.22	Yes	No	0	3	6
156	R:R:F180	R:R:F276	6.43	Yes	Yes	1	3	4
157	R:R:F180	R:R:L280	3.65	Yes	No	1	3	5
158	R:R:I182	R:R:I254	4.42	Yes	No	1	3	4
159	R:R:I182	R:R:L258	4.28	Yes	Yes	1	3	3
160	R:R:I182	R:R:Y269	4.84	Yes	No	1	3	2
161	R:R:D273	R:R:I182	7	No	Yes	0	4	3
162	R:R:C183	R:R:Q187	3.05	Yes	No	0	1	2
163	R:R:H184	R:R:T263	10.95	No	No	0	3	3
164	R:R:F186	W:W:?1	5.32	No	Yes	0	4	0
165	R:R:E190	R:R:Q187	3.82	Yes	No	0	4	2
166	R:R:M192	R:R:W188	9.31	No	No	0	5	5
167	R:R:E190	R:R:R251	10.47	Yes	No	0	4	5
168	R:R:E190	R:R:F255	3.5	Yes	No	1	4	5
169	R:R:E190	W:W:?1	7.72	Yes	Yes	1	4	0
170	R:R:A191	W:W:?1	4.59	No	Yes	0	3	0
171	R:R:F193	R:R:R251	3.21	No	No	0	6	5
172	R:R:I252	R:R:L194	2.85	No	No	0	6	4
173	R:R:F255	R:R:L194	3.65	No	No	1	5	4
174	R:R:L194	W:W:?1	3.02	No	Yes	1	4	0
175	R:R:L195	W:W:?1	4.03	No	Yes	0	4	0
176	R:R:F197	R:R:F198	6.43	Yes	No	0	8	5
177	R:R:F197	R:R:F240	6.43	Yes	No	0	8	9
178	R:R:F197	R:R:L245	3.65	Yes	Yes	0	8	6
179	R:R:F197	R:R:V248	3.93	Yes	No	0	8	8
180	R:R:F198	W:W:?1	3.55	No	Yes	0	5	0
181	R:R:L199	R:R:P200	3.28	No	No	0	4	9
182	R:R:L201	R:R:L205	4.15	No	No	0	7	4
183	R:R:F240	R:R:L201	3.65	No	No	0	9	7
184	R:R:F206	R:R:R210	7.48	No	No	5	4	4
185	R:R:I233	R:R:S208	3.1	No	No	0	7	8
186	R:R:I212	R:R:R216	3.76	Yes	No	0	5	4
187	R:R:I212	R:R:I230	4.42	Yes	No	0	5	6
188	R:R:I212	R:R:I233	2.94	Yes	No	0	5	7
189	R:R:I212	R:R:M234	2.92	Yes	No	0	5	4
190	R:R:Q217	R:R:W213	8.76	No	No	0	5	3
191	R:R:R218	R:R:S214	5.27	No	No	0	5	5
192	R:R:I226	R:R:L215	7.14	No	No	0	6	8
193	R:R:D221	R:R:R216	7.15	No	No	0	3	4
194	R:R:D221	R:R:R222	4.76	No	No	0	3	3
195	R:R:H223	R:R:K225	3.93	No	No	0	4	5
196	R:R:F232	R:R:R228	6.41	No	No	0	7	7
197	R:R:F232	R:R:T231	3.89	No	No	0	7	6
198	R:R:F232	R:R:S297	7.93	No	No	0	7	6
199	R:R:V236	R:R:Y294	7.57	No	Yes	0	8	9
200	R:R:L289	R:R:V239	2.98	No	No	0	7	7
201	R:R:F240	R:R:F244	4.29	No	Yes	0	9	8
202	R:R:L245	R:R:V241	4.47	Yes	No	0	6	5
203	R:R:C243	R:R:F244	2.79	No	Yes	8	8	8
204	R:R:C243	R:R:N286	9.45	No	No	8	8	9
205	R:R:F244	R:R:T283	5.19	Yes	No	0	8	8
206	R:R:F244	R:R:N286	12.08	Yes	No	8	8	9
207	R:R:L245	R:R:P246	3.28	Yes	No	0	6	9
208	R:R:L245	R:R:V249	2.98	Yes	No	0	6	6
209	R:R:F282	R:R:P246	5.78	No	No	0	7	9
210	R:R:S247	R:R:T279	3.2	No	No	0	6	7
211	R:R:T279	R:R:V250	3.17	No	No	0	7	5
212	R:R:F276	R:R:R251	19.24	Yes	No	0	4	5
213	R:R:R253	R:R:W256	5	No	No	0	5	4
214	R:R:L257	R:R:R253	10.93	No	No	0	3	5
215	R:R:I254	R:R:L258	2.85	No	Yes	1	4	3
216	R:R:I254	R:R:V272	3.07	No	No	0	4	4
217	R:R:F255	W:W:?1	14.19	No	Yes	1	5	0
218	R:R:H259	R:R:W256	3.17	No	No	0	1	4
219	R:R:T260	R:R:W256	7.28	No	No	0	1	4
220	R:R:L257	R:R:V272	2.98	No	No	0	3	4
221	R:R:L258	R:R:Y269	7.03	Yes	No	1	3	2
222	R:R:L258	W:W:?1	7.06	Yes	Yes	1	3	0
223	R:R:S261	R:R:T260	3.2	No	No	0	3	1
224	R:R:E267	R:R:R270	12.79	No	Yes	0	2	1
225	R:R:S271	R:R:V272	3.23	No	No	0	3	4
226	R:R:D273	R:R:F277	7.17	No	No	0	4	5
227	R:R:I278	R:R:L274	2.85	No	No	0	6	1
228	R:R:F276	R:R:T279	5.19	Yes	No	0	4	7
229	R:R:F276	R:R:L280	9.74	Yes	No	1	4	5
230	R:R:L289	R:R:M285	4.24	No	No	0	7	5
231	R:R:D290	R:R:Y294	3.45	No	Yes	0	9	9
232	R:R:P291	R:R:Y295	4.17	No	Yes	0	9	7
233	R:R:Y294	R:R:Y295	2.98	Yes	Yes	0	9	7
234	R:R:A48	R:R:Y295	2.67	No	Yes	0	9	7
235	R:R:F65	R:R:S148	2.64	No	No	0	7	8
236	R:R:H189	R:R:M192	2.63	Yes	No	0	5	5
237	R:R:E267	R:R:N265	2.63	No	No	0	2	5
238	R:R:R90	R:R:V27	2.62	No	No	0	4	3
239	R:R:R89	R:R:V88	2.62	No	No	0	4	3
240	R:R:F105	R:R:V160	2.62	Yes	No	0	6	4
241	R:R:F127	R:R:V123	2.62	No	No	0	5	6
242	R:R:A72	R:R:W152	2.59	No	No	0	8	9
243	R:R:H134	R:R:L136	2.57	No	No	0	4	4
244	R:R:F38	R:R:I77	2.51	No	No	0	7	6
245	R:R:F40	R:R:I39	2.51	No	No	0	6	5
246	R:R:F65	R:R:I147	2.51	No	No	0	7	5
247	R:R:F38	R:R:L80	2.44	No	No	0	7	8
248	R:R:F74	R:R:N45	2.42	No	No	0	7	9
249	R:R:N171	R:R:R22	2.41	No	No	0	1	3
250	R:R:D24	R:R:R90	2.38	No	No	0	4	4
251	R:R:D92	R:R:R89	2.38	No	No	0	4	4
252	R:R:L56	R:R:W59	2.28	No	No	0	5	6
253	R:R:G172	R:R:G173	2.11	No	No	0	3	4
254	R:R:R210	R:R:W213	2	No	No	0	4	3
255	R:R:P31	R:R:V88	1.77	No	No	0	6	3
256	R:R:G41	R:R:I77	1.76	No	No	0	8	6
257	R:R:G35	R:R:M84	1.75	No	No	0	5	7
258	R:R:G41	R:R:M288	1.75	No	No	0	8	8
259	R:R:C183	R:R:S181	1.72	Yes	No	0	1	4
260	R:R:G44	R:R:L43	1.71	No	No	0	7	4
261	R:R:G202	R:R:L201	1.71	No	No	0	3	7
262	R:R:C19	R:R:T263	1.69	No	No	0	4	3
263	R:R:M84	R:R:P31	1.68	No	No	0	7	6
264	R:R:C207	R:R:I203	1.64	No	No	0	8	7
265	R:R:S297	R:R:S298	1.63	No	No	0	6	8
266	R:R:A145	R:R:I64	1.62	No	Yes	0	3	7
267	R:R:A122	R:R:I204	1.62	No	Yes	0	9	8
268	R:R:A237	R:R:I204	1.62	No	Yes	0	7	8
269	R:R:S297	R:R:V293	1.62	No	No	0	6	8
270	R:R:V235	R:R:V293	1.6	No	No	0	5	8
271	R:R:V292	R:R:V293	1.6	No	No	0	6	8
272	R:R:C266	R:R:L11	1.59	No	No	0	7	8
273	R:R:G262	R:R:H184	1.59	No	No	0	4	3
274	R:R:I204	R:R:S208	1.55	Yes	No	0	8	8
275	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
276	R:R:H133	R:R:P132	1.53	No	No	0	6	8
277	R:R:I139	R:R:T143	1.52	No	No	0	7	3
278	R:R:M109	R:R:T155	1.51	Yes	No	0	5	7
279	R:R:L34	R:R:S281	1.5	No	Yes	0	8	6
280	R:R:L56	R:R:S58	1.5	No	No	0	5	6
281	R:R:L49	R:R:V71	1.49	No	No	0	7	6
282	R:R:L215	R:R:V129	1.49	No	No	0	8	8
283	R:R:L257	R:R:V268	1.49	No	No	0	3	1
284	R:R:L289	R:R:V292	1.49	No	No	0	7	6
285	R:R:I116	R:R:I154	1.47	No	No	0	5	5
286	R:R:I238	R:R:I242	1.47	No	No	0	5	5
287	R:R:A135	R:R:H134	1.46	No	No	0	5	4
288	R:R:I226	R:R:M220	1.46	No	No	0	6	3
289	R:R:A224	R:R:H223	1.46	No	No	0	3	4
290	R:R:K15	R:R:K165	1.44	No	No	0	3	4
291	R:R:F296	R:R:P291	1.44	No	No	0	8	9
292	R:R:I98	R:R:L102	1.43	No	No	0	2	5
293	R:R:I146	R:R:L150	1.43	No	No	0	3	4
294	R:R:I64	R:R:N141	1.42	Yes	No	0	7	2
295	R:R:D97	R:R:K166	1.38	No	No	0	3	4
296	R:R:H55	R:R:I51	1.33	No	No	0	5	7
297	R:R:H223	R:R:I226	1.33	No	No	0	4	6
298	R:R:R142	R:R:S140	1.32	No	No	0	4	6
299	R:R:F25	R:R:V29	1.31	No	No	0	6	5
300	R:R:H161	R:R:K165	1.31	No	No	0	7	4
301	R:R:F296	R:R:L47	1.22	No	No	0	8	6
302	R:R:L56	R:R:R63	1.21	No	No	0	5	7
303	R:R:L66	R:R:R63	1.21	No	No	0	8	7
304	R:R:Q219	R:R:R222	1.17	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.61	8	1	0
2	R:R:F21	6.11	4	3	2
3	R:R:L30	5.005	4	1	5
4	R:R:E37	3.9475	4	1	7
5	R:R:I64	2.4525	4	0	7
6	R:R:Y87	6.904	5	1	6
7	R:R:W91	6.3325	4	0	4
8	R:R:W93	5.488	5	2	9
9	R:R:F95	7.05	4	2	7
10	R:R:C100	5.675	4	2	9
11	R:R:F105	6.2525	4	4	6
12	R:R:M109	3.925	6	4	5
13	R:R:N110	5.1775	4	4	9
14	R:R:R111	4.8675	4	1	8
15	R:R:Y126	6.50333	6	5	7
16	R:R:H131	5.2975	4	5	7
17	R:R:F180	6.02	6	1	3
18	R:R:I182	5.135	4	1	3
19	R:R:C183	4.63	4	6	1
20	R:R:H189	5.18	4	0	5
21	R:R:E190	6.502	5	1	4
22	R:R:F197	5.11	4	0	8
23	R:R:I204	1.9575	4	0	8
24	R:R:I212	3.51	4	0	5
25	R:R:F244	6.126	5	8	8
26	R:R:L245	3.595	4	0	6
27	R:R:L258	5.305	4	1	3
28	R:R:R270	8.015	4	3	1
29	R:R:F276	10.15	4	1	4
30	R:R:S281	3.415	4	1	6
31	R:R:Y284	4.405	4	1	7
32	R:R:Y294	4.53	4	0	9
33	R:R:Y295	3.75571	7	0	7
34	W:W:?1	6.185	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y87	33.4425	4.35	Yes	Yes	1	0	6
2	R:R:I26	R:R:Y87	29.9994	6.04	No	Yes	1	5	6
3	R:R:I26	R:R:L274	29.7553	2.85	No	No	0	5	1
4	R:R:D23	R:R:L274	29.524	2.71	No	No	0	4	1
5	R:R:D23	R:R:R270	27.4812	10.72	No	Yes	0	4	1
6	R:R:F21	R:R:R270	19.3037	5.34	Yes	Yes	3	2	1
7	L:L:?1	R:R:L83	51.2366	6.42	Yes	No	1	0	6
8	R:R:L83	R:R:M103	56.048	5.65	No	No	0	6	5
9	R:R:M103	R:R:W93	54.6669	3.49	No	Yes	0	5	9
10	R:R:F95	R:R:W93	46.1039	10.02	Yes	Yes	2	7	9
11	R:R:F95	R:R:K94	38.0227	9.93	Yes	No	0	7	3
12	R:R:K94	R:R:R89	34.4511	12.38	No	No	0	3	4
13	R:R:D92	R:R:R89	23.4278	2.38	No	No	0	4	4
14	R:R:A174	R:R:D92	21.5456	3.09	No	No	0	2	4
15	R:R:A174	R:R:R22	19.6505	4.15	No	No	0	2	3
16	R:R:N171	R:R:R22	11.9419	2.41	No	No	0	1	3
17	L:L:?1	R:R:F180	61.6625	9.03	Yes	Yes	1	0	3
18	R:R:E190	R:R:F180	40.4253	7	Yes	Yes	1	4	3
19	R:R:E190	R:R:Q187	10.4066	3.82	Yes	No	0	4	2
20	R:R:L30	R:R:Y87	11.261	7.03	Yes	Yes	1	5	6
21	L:L:?1	R:R:Y284	29.0229	6.52	Yes	Yes	1	0	7
22	R:R:E37	R:R:Y284	23.3635	4.49	Yes	Yes	1	7	7
23	R:R:E37	R:R:M285	20.5563	2.71	Yes	No	0	7	5
24	R:R:L80	R:R:Y284	16.4129	3.52	No	Yes	0	8	7
25	R:R:F38	R:R:L80	14.6399	2.44	No	No	0	7	8
26	R:R:F38	R:R:I77	11.0554	2.51	No	No	0	7	6
27	L:L:?1	R:R:L107	100	6.42	Yes	No	0	0	6
28	R:R:L107	R:R:L76	98.9658	2.77	No	No	0	6	7
29	R:R:L76	R:R:S287	70.2897	3	No	No	0	7	8
30	R:R:D73	R:R:S287	68.9343	2.94	No	No	0	9	8
31	R:R:D73	R:R:N45	67.566	14.81	No	No	0	9	9
32	R:R:N45	R:R:P291	63.3841	6.52	No	No	0	9	9
33	R:R:F296	R:R:P291	13.0789	1.44	No	No	0	8	9
34	R:R:F296	R:R:L47	11.2482	1.22	No	No	0	8	6
35	R:R:P291	R:R:Y295	51.667	4.17	No	Yes	0	9	7
36	R:R:F52	R:R:Y295	24.4492	3.09	No	Yes	0	7	7
37	R:R:F52	R:R:F67	22.9524	7.5	No	No	0	7	6
38	R:R:F67	R:R:W59	17.9932	3.01	No	No	0	6	6
39	R:R:I64	R:R:W59	16.7598	3.52	Yes	No	0	7	6
40	R:R:A144	R:R:I64	11.2867	3.25	No	Yes	0	7	7
41	L:L:?1	R:R:R111	69.1848	9.01	Yes	Yes	1	0	8
42	R:R:E196	R:R:R111	60.9045	3.49	No	Yes	0	5	8
43	R:R:E196	R:R:I115	59.8381	6.83	No	No	0	5	8
44	R:R:I115	R:R:P200	69.1077	3.39	No	No	0	8	9
45	R:R:P200	R:R:T119	66.5639	3.5	No	No	0	9	7
46	R:R:I203	R:R:T119	48.7763	4.56	No	No	0	7	7
47	R:R:C207	R:R:I203	47.318	1.64	No	No	0	8	7
48	R:R:C207	R:R:Y126	45.847	8.06	No	Yes	0	8	7
49	R:R:H131	R:R:Y126	20.6848	5.44	Yes	Yes	5	7	7
50	R:R:F127	R:R:H131	15.8027	4.53	No	Yes	0	5	7
51	R:R:F127	R:R:L136	12.3338	3.65	No	No	0	5	4
52	R:R:H134	R:R:L136	10.5801	2.57	No	No	0	4	4
53	R:R:L76	R:R:N110	40.6244	6.87	No	Yes	0	7	9
54	R:R:M109	R:R:N110	33.8023	2.8	Yes	Yes	4	5	9
55	R:R:M109	R:R:T155	23.7939	1.51	Yes	No	0	5	7
56	R:R:I116	R:R:T155	20.2737	4.56	No	No	0	5	7
57	R:R:I116	R:R:L151	16.702	5.71	No	No	0	5	7
58	R:R:F117	R:R:L151	14.8969	4.87	No	No	0	8	7
59	R:R:W91	R:R:Y87	14.0104	7.72	Yes	Yes	0	4	6
60	R:R:N86	R:R:W91	12.6871	5.65	No	Yes	0	5	4
61	R:R:C100	R:R:W93	17.3765	6.53	Yes	Yes	2	9	9
62	R:R:R111	R:R:T283	17.4729	3.88	Yes	No	0	8	8
63	L:L:?1	R:R:S179	15.3273	2.78	Yes	No	0	0	4
64	R:R:H189	R:R:S179	14.0361	8.37	Yes	No	0	5	4
65	R:R:H189	R:R:M192	24.6611	2.63	Yes	No	0	5	5
66	R:R:F180	R:R:H189	17.0939	6.79	Yes	Yes	0	3	5
67	R:R:F244	R:R:T283	16.5286	5.19	Yes	No	0	8	8
68	R:R:I204	R:R:T119	21.1152	3.04	Yes	No	0	8	7
69	R:R:I211	R:R:Y126	14.0939	3.63	No	Yes	0	8	7
70	R:R:I211	R:R:V129	12.3531	6.14	No	No	0	8	8
71	R:R:M192	R:R:W188	18.3529	9.31	No	No	0	5	5
72	R:R:H161	R:R:W188	12.1796	3.17	No	No	0	7	5
73	R:R:E190	W:W:?1	28.1172	7.72	Yes	Yes	1	4	0
74	R:R:L258	W:W:?1	17.3187	7.06	Yes	Yes	1	3	0
75	R:R:I254	R:R:L258	12.9055	2.85	No	Yes	1	4	3
76	R:R:F240	R:R:F244	22.6248	4.29	No	Yes	0	9	8
77	R:R:F197	R:R:F240	17.9739	6.43	Yes	No	0	8	9
78	R:R:F198	W:W:?1	17.7234	3.55	No	Yes	0	5	0
79	R:R:F197	R:R:F198	16.8497	6.43	Yes	No	0	8	5
80	R:R:F197	R:R:L245	13.1303	3.65	Yes	Yes	0	8	6
81	R:R:I204	R:R:S208	16.0082	1.55	Yes	No	0	8	8
82	R:R:I233	R:R:S208	14.2802	3.1	No	No	0	7	8
83	R:R:I212	R:R:I233	12.5265	2.94	Yes	No	0	5	7
84	R:R:L215	R:R:V129	10.5929	1.49	No	No	0	8	8
85	R:R:L289	R:R:M285	18.6998	4.24	No	No	0	7	5
86	R:R:L289	R:R:V292	14.9483	1.49	No	No	0	7	6
87	R:R:V292	R:R:V293	13.0533	1.6	No	No	0	6	8
88	R:R:I254	R:R:V272	15.7191	3.07	No	No	0	4	4
89	R:R:L257	R:R:V272	12.3145	2.98	No	No	0	3	4
90	R:R:F277	R:R:W91	11.5822	7.02	No	Yes	0	5	4
91	R:R:R111	R:R:Y284	10.0726	3.09	Yes	Yes	1	8	7
92	R:R:F244	R:R:I115	10.7086	6.28	Yes	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	6.42	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y87	4.35	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L107	6.42	1	Yes	No	0	6	0	1
L:L:?1	R:R:R111	9.01	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S178	8.35	1	Yes	No	0	4	0	1
L:L:?1	R:R:S179	2.78	1	Yes	No	0	4	0	1
L:L:?1	R:R:F180	9.03	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y284	6.52	1	Yes	Yes	0	7	0	1
R:R:I26	R:R:L30	7.14	1	No	Yes	5	5	2	2
R:R:I26	R:R:Y87	6.04	1	No	Yes	5	6	2	1
R:R:L30	R:R:Y87	7.03	1	Yes	Yes	5	6	2	1
R:R:E37	R:R:Y284	4.49	1	Yes	Yes	7	7	2	1
R:R:L107	R:R:L76	2.77	0	No	No	6	7	1	2
R:R:L80	R:R:Y284	3.52	0	No	Yes	8	7	2	1
R:R:L83	R:R:Y87	9.38	1	No	Yes	6	6	1	1
R:R:L83	R:R:M103	5.65	1	No	No	6	5	1	2
R:R:W91	R:R:Y87	7.72	0	Yes	Yes	4	6	2	1
R:R:S178	R:R:W91	4.94	0	No	Yes	4	4	1	2
R:R:E196	R:R:R111	3.49	0	No	Yes	5	8	2	1
R:R:R111	R:R:T283	3.88	1	Yes	No	8	8	1	2
R:R:R111	R:R:Y284	3.09	1	Yes	Yes	8	7	1	1
R:R:H189	R:R:S179	8.37	0	Yes	No	5	4	2	1
R:R:F180	R:R:H189	6.79	1	Yes	Yes	3	5	1	2
R:R:E190	R:R:F180	7	1	Yes	Yes	4	3	2	1
R:R:F180	R:R:F193	3.22	1	Yes	No	3	6	1	2
R:R:F180	R:R:F276	6.43	1	Yes	Yes	3	4	1	2
R:R:F180	R:R:L280	3.65	1	Yes	No	3	5	1	2
R:R:F276	R:R:L280	9.74	1	Yes	No	4	5	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E190	R:R:F180	7	1	Yes	Yes	4	3	1	2
R:R:I182	R:R:I254	4.42	1	Yes	No	3	4	2	2
R:R:I182	R:R:L258	4.28	1	Yes	Yes	3	3	2	1
R:R:I182	R:R:Y269	4.84	1	Yes	No	3	2	2	2
R:R:F186	W:W:?1	5.32	0	No	Yes	4	0	1	0
R:R:E190	R:R:Q187	3.82	1	Yes	No	4	2	1	2
R:R:E190	R:R:R251	10.47	1	Yes	No	4	5	1	2
R:R:E190	R:R:F255	3.5	1	Yes	No	4	5	1	1
R:R:E190	W:W:?1	7.72	1	Yes	Yes	4	0	1	0
R:R:A191	W:W:?1	4.59	0	No	Yes	3	0	1	0
R:R:I252	R:R:L194	2.85	0	No	No	6	4	2	1
R:R:F255	R:R:L194	3.65	1	No	No	5	4	1	1
R:R:L194	W:W:?1	3.02	1	No	Yes	4	0	1	0
R:R:L195	W:W:?1	4.03	0	No	Yes	4	0	1	0
R:R:F197	R:R:F198	6.43	0	Yes	No	8	5	2	1
R:R:F198	W:W:?1	3.55	0	No	Yes	5	0	1	0
R:R:I254	R:R:L258	2.85	1	No	Yes	4	3	2	1
R:R:F255	W:W:?1	14.19	1	No	Yes	5	0	1	0
R:R:L258	R:R:Y269	7.03	1	Yes	No	3	2	1	2
R:R:L258	W:W:?1	7.06	1	Yes	Yes	3	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JII_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.71
Number of Linked Nodes	275
Number of Links	304
Number of Hubs	34
Number of Links mediated by Hubs	133
Number of Communities	8
Number of Nodes involved in Communities	51
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	93
Number Of Links MetaPath	92
Number of Shortest Paths	41955
Length Of Smallest Path	3
Average Path Length	13.3884
Length of Longest Path	34
Minimum Path Strength	1.21
Average Path Strength	5.23639
Maximum Path Strength	14.855
Minimum Path Correlation	0.7
Average Path Correlation	0.916432
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	46.7094
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.4321
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • inflammatory cell apoptotic process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • positive regulation of cell communication • establishment of protein localization • system process • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • adiponectin secretion • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of multicellular organismal process • regulation of hormone secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • negative regulation of metabolic process • negative regulation of biological process • regulation of catabolic process • regulation of lipid catabolic process • negative regulation of cellular process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NIO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NIO
Name	Niacin
Synonyms	3-carboxypyridine
Identifier
Formula	C6 H5 N O2
Molecular Weight	123.109
SMILES
PubChem	938
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	14
Total Aromatic Bonds	6


Code	IX8
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	IX8
Name	7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide
Synonyms
Identifier
Formula	C26 H28 N4 O2
Molecular Weight	428.526
SMILES
PubChem	25101223
Formal Charge	0
Total Atoms	60
Total Chiral Atoms	1
Total Bonds	63
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8JII_nogp_Chain_R F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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