Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F21 7.6675472
2R:R:L34 4.2548
3R:R:E37 4.915407
4R:R:N45 5.635619
5R:R:F52 5.51333617
6R:R:R63 5.475407
7R:R:F65 6.435407
8R:R:F67 4.784516
9R:R:L69 5.2975419
10R:R:D73 8.192519
11R:R:L76 7407
12R:R:I77 3.7975416
13R:R:Y87 4.142546
14R:R:W91 8.39504
15R:R:W93 12.5559
16R:R:F95 11.6025407
17R:R:C100 6.1925459
18R:R:M109 5.76625
19R:R:N110 8.625419
20R:R:R111 5.84408
21R:R:Q112 5.1025427
22R:R:I115 6.18418
23R:R:F117 11.15428
24R:R:Y126 6.05429737
25R:R:F127 5.81833635
26R:R:R128 7.7225498
27R:R:H131 5.0275437
28R:R:W152 7.274529
29R:R:T155 3.716527
30R:R:I156 3.625424
31R:R:N171 4.5025401
32R:R:E190 9.184114
33R:R:F197 6.3618
34R:R:L201 3.6375417
35R:R:R210 5.126534
36R:R:L215 4.9408
37R:R:I230 3.8825406
38R:R:F232 7.116507
39R:R:F240 5.515619
40R:R:F244 5.864518
41R:R:L245 3.2225406
42R:R:Y269 4.904502
43R:R:F276 8.195404
44R:R:Y284 5.43667647
45R:R:N286 6.816519
46R:R:V287 4.882518
47R:R:L289 3.245407
48R:R:Y294 5.1819
49R:R:F296 6.748568
50R:R:F304 9.804514
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D14 R:R:N171 11.01544.04NoYes051
2R:R:L176 R:R:N171 21.72644.12NoYes041
3R:R:L176 R:R:W91 32.42543.42NoYes044
4R:R:W91 R:R:Y87 71.19773.86YesYes046
5R:R:L34 R:R:Y87 58.49793.52YesYes486
6R:R:L34 R:R:Y284 34.76873.52YesYes487
7R:R:L76 R:R:Y284 1007.03YesYes077
8R:R:L76 R:R:N110 64.27813.73YesYes079
9R:R:N110 R:R:N286 18.175412.26YesYes199
10R:R:F244 R:R:N286 41.86666.04YesYes189
11R:R:F197 R:R:F244 42.81793.22YesYes188
12R:R:F197 R:R:V248 50.312414.42YesNo088
13R:R:I252 R:R:V248 49.01863.07NoNo068
14R:R:I252 R:R:L194 47.71885.71NoNo064
15R:R:F186 R:R:L194 46.4134.87NoNo044
16R:R:F186 R:R:F255 43.799311.79NoNo045
17R:R:E190 R:R:F255 42.48555.83YesNo045
18R:R:E190 R:R:Q187 33.35673.82YesNo1142
19R:R:Q187 R:R:T185 32.05894.25NoNo022
20R:R:L258 R:R:T185 30.7092.95NoNo032
21R:R:L258 R:R:Y269 26.63538.21NoYes032
22R:R:L83 R:R:Y87 30.14825.86NoYes466
23R:R:L83 R:R:Y284 31.05355.86NoYes467
24R:R:L34 R:R:L80 31.82862.77YesNo088
25R:R:L76 R:R:L80 35.60182.77YesNo078
26R:R:L76 R:R:V287 69.24694.47YesYes078
27R:R:N286 R:R:V287 19.94194.43YesYes198
28R:R:F277 R:R:W91 13.264613.03NoYes054
29R:R:F276 R:R:F277 15.37159.65YesNo045
30R:R:F276 R:R:R251 16.519110.69YesNo045
31R:R:F193 R:R:R251 16.905712.83NoNo065
32R:R:F193 R:R:R111 17.20018.55NoYes068
33R:R:I115 R:R:R111 37.8276.26YesYes088
34R:R:F244 R:R:I115 17.41848.79YesYes188
35R:R:F240 R:R:I115 20.6956.28YesYes198
36R:R:F197 R:R:F240 15.46776.43YesYes189
37R:R:R22 R:R:W91 46.931715.99NoYes034
38R:R:R22 R:R:V27 22.31923.92NoNo033
39R:R:R22 R:R:R90 22.317217.06NoNo034
40R:R:D23 R:R:D24 27.93713.99NoNo044
41R:R:D24 R:R:K28 33.51296.91NoNo043
42R:R:K28 R:R:V27 19.543410.62NoNo033
43R:R:K28 R:R:R90 19.54343.71NoNo034
44R:R:D23 R:R:F25 11.18573.58NoNo046
45R:R:D23 R:R:L274 11.18578.14NoNo041
46R:R:E37 R:R:Y284 20.24634.49YesYes077
47R:R:D73 R:R:N45 36.841612.12YesYes199
48R:R:F240 R:R:L118 13.61313.65YesNo099
49R:R:L118 R:R:L69 13.70725.54NoYes099
50R:R:L69 R:R:Y294 27.08195.86YesYes199
51R:R:I77 R:R:V287 21.26983.07YesYes168
52R:R:F301 R:R:Y294 25.09113.09NoYes199
53R:R:F301 R:R:I51 23.30867.54NoNo197
54R:R:F304 R:R:I51 18.299612.56YesNo147
55R:R:F52 R:R:Y294 27.74484.13YesYes179
56R:R:F52 R:R:R63 22.8664.28YesYes077
57R:R:L66 R:R:Y294 39.61755.86NoYes189
58R:R:Q112 R:R:R111 36.12064.67YesYes078
59R:R:Q112 R:R:T155 34.33012.83YesYes277
60R:R:I116 R:R:T155 34.52233.04NoYes057
61R:R:I116 R:R:L151 33.99965.71NoNo057
62R:R:I147 R:R:L151 42.1632.85NoNo057
63R:R:F65 R:R:I147 41.46817.54YesNo075
64R:R:D124 R:R:F65 32.80594.78NoYes087
65R:R:D124 R:R:R128 31.281811.91NoYes988
66R:R:R63 R:R:S298 15.34353.95YesNo078
67R:R:L66 R:R:S297 37.81493NoNo086
68R:R:D290 R:R:D73 29.088710.65NoYes199
69R:R:M109 R:R:T155 13.67513.01YesYes257
70R:R:L75 R:R:M109 19.41522.83NoYes065
71R:R:L75 R:R:M106 19.63354.24NoNo065
72R:R:L107 R:R:Y284 33.28465.86NoYes067
73R:R:C79 R:R:L107 32.55763.17NoNo066
74R:R:C79 R:R:M106 20.59486.48NoNo065
75R:R:C79 R:R:M103 27.37434.86NoNo065
76R:R:M103 R:R:W93 26.31885.82NoYes059
77R:R:F95 R:R:W93 13.811320.04YesYes079
78R:R:C100 R:R:W93 11.29987.84YesYes599
79R:R:F232 R:R:S297 35.25543.96YesNo076
80R:R:N137 R:R:R128 29.88588.44NoYes048
81R:R:F127 R:R:N137 28.35573.62YesNo054
82R:R:F127 R:R:Y126 21.92273.09YesYes357
83R:R:I211 R:R:Y126 15.55983.63NoYes087
84R:R:I211 R:R:V129 12.20116.14NoNo088
85R:R:L215 R:R:V129 11.34997.45YesNo088
86R:R:F232 R:R:F296 20.20432.14YesYes078
87R:R:P299 R:R:S298 10.38855.34NoNo058
88R:R:D73 R:R:N110 31.37994.04YesYes199
89R:R:D73 R:R:V287 31.428.76YesYes198
90R:R:I77 R:R:N45 17.01784.25YesYes169
91R:R:N45 R:R:Y294 42.65774.65YesYes199
92R:R:D290 R:R:Y294 28.15746.9NoYes199
93R:R:N110 R:R:S114 14.93894.47YesNo199
94R:R:L69 R:R:S114 14.93693YesNo199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7ZLY
Class A
SubFamily Alicarboxylic acid
Type Hydroxycarboxylic acid
SubType HCA2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.7
Date 2023-04-12 
D.O.I. 10.1038/s41467-023-37177-6
Net Summary
Imin 2.98
Number of Linked Nodes 288
Number of Links 342
Number of Hubs 50
Number of Links mediated by Hubs 192
Number of Communities 11
Number of Nodes involved in Communities 74
Number of Links involved in Communities 102
Path Summary
Number Of Nodes in MetaPath 95
Number Of Links MetaPath 94
Number of Shortest Paths 116533
Length Of Smallest Path 3
Average Path Length 15.573
Length of Longest Path 38
Minimum Path Strength 1.545
Average Path Strength 6.03988
Maximum Path Strength 20.465
Minimum Path Correlation 0.7
Average Path Correlation 0.929092
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.22581
Average % Of Corr. Nodes 44.5098
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.2359
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8TDS4
Sequence
>7ZLY_Chain_R
LEIDKKNCC VFRDDFIVK VLPPVLGLE FIFGLLGNG LALWIFCFH 
LKSWKSSRI FLFNLVVAD FLLIICLPF LMDNYVRRW DWKFGDIPC 
RLMLFMLAM NRQGSIIFL TVVAVDRYF RVVHPHHAL NKISNRTAA 
IISCLLWGI TIGLTVHLL KKKMPIQNA NLCSSFSIC HTFQWHEAM 
FLLEFFLPL GIILFCSAR IIWSLRQRQ MDRHAKIKR AITFIMVVA 
IVFVICFLP SVVVRIRIF WLLHTSGTQ NCEVYRSVD LAFFITLSF 
TYMNVMLDP VVYYFSSPS FPNFFSTLI NRC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XK2AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;23.12023-02-2210.1038/s41467-023-37177-6
7ZL9AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiens---2.72023-04-1210.1038/s41467-023-37177-6
8H2GAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/&β;1/&γ;23.012023-10-11To be published
8I7VAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcipimox-Gi1/&β;1/&γ;22.772024-02-0710.1038/s41467-023-42764-8
8I7WAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073-Gi1/&β;1/&γ;23.392024-02-0710.1038/s41467-023-42764-8
8IHBAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073-Gi1/&β;1/&γ;22.852023-09-1310.1038/s41467-023-41650-7
8IHFAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;22.972023-08-3010.1038/s41467-023-41650-7
8IHHAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensLUF6283-Gi1/&β;1/&γ;23.062023-08-3010.1038/s41467-023-41650-7
8IHIAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcifran-Gi1/&β;1/&γ;23.112023-08-3010.1038/s41467-023-41650-7
8IJ3AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiens--Gi1/&β;1/&γ;23.282024-01-0310.1038/s41421-023-00610-7
8IJAAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/&β;1/&γ;22.692024-01-0310.1038/s41421-023-00610-7
8IJBAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcipimox-Gi1/&β;1/&γ;23.232024-01-0310.1038/s41421-023-00610-7
8IJDAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;23.252024-01-0310.1038/s41421-023-00610-7
8IY9AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Go/&β;1/&γ;23.372024-03-0610.1038/s41467-024-46239-2
8IYHAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Go/&β;1/&γ;23.32024-03-0610.1038/s41467-024-46239-2
8IYWAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073-Go/&β;1/&γ;23.452024-03-0610.1038/s41467-024-46239-2
8J6IAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;22.922024-04-0310.1016/j.celrep.2023.113406
8J6JAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073-Gi1/&β;1/&γ;22.82024-01-1010.1016/j.celrep.2023.113406
8J6LAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/&β;1/&γ;23.052024-04-0310.1016/j.celrep.2023.113406
8J6PAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacinCompound 9nGi1/&β;1/&γ;22.552023-12-0610.1038/s41467-023-43537-z
8J6QAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensBeta-hydroxybutyrateCompound 9nGi1/&β;1/&γ;22.62023-12-0610.1038/s41467-023-43537-z
8J6RAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;22.762023-12-0610.1038/s41467-023-43537-z
8JERAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcipimox-Go/&β;1/&γ;23.452024-03-0610.1038/s41467-024-46239-2
8JHNAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMMF-Go/&β;1/&γ;23.752024-03-0610.1038/s41467-024-46239-2
8JHYAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiens-Compound 9nGi1/&β;1/&γ;22.872023-09-0610.1016/j.molcel.2023.07.030
8JIIAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacinCompound 9nGi1/&β;1/&γ;23.172023-09-0610.1016/j.molcel.2023.07.030
8JILAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/&β;1/&γ;23.52023-09-0610.1016/j.molcel.2023.07.030
8JIMAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMMF-Gi1/&β;1/&γ;22.982023-09-0610.1016/j.molcel.2023.07.030
8JZ7AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;22.62023-10-0410.1038/s41392-023-01625-y
8K5BAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin--3.432023-11-2210.1038/s41467-023-42764-8
8K5CAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcipimox--3.132023-11-2210.1038/s41467-023-42764-8
8K5DAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073--3.742023-11-2210.1038/s41467-023-42764-8




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7ZLY.zip



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