psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	5.13	Yes	No	0	0	6
2	L:L:?1	R:R:L107	8.98	Yes	No	0	0	6
3	L:L:?1	R:R:R111	10.14	Yes	Yes	1	0	8
4	L:L:?1	R:R:S179	6.96	Yes	No	0	0	4
5	L:L:?1	R:R:F180	10.16	Yes	Yes	1	0	3
6	L:L:?1	R:R:L280	11.55	Yes	No	0	0	5
7	L:L:?1	R:R:Y284	7.61	Yes	Yes	0	0	7
8	R:R:D8	R:R:F10	7.17	No	No	0	6	7
9	R:R:F21	R:R:H9	19.23	No	No	0	2	6
10	R:R:L11	R:R:V20	4.47	No	No	4	8	2
11	R:R:L11	R:R:N171	6.87	No	No	4	8	1
12	R:R:E12	R:R:N17	9.2	No	No	0	5	5
13	R:R:D14	R:R:I13	5.6	No	No	0	5	3
14	R:R:C18	R:R:I13	4.91	No	No	0	9	3
15	R:R:I13	R:R:I169	14.72	No	No	0	3	1
16	R:R:D14	R:R:K165	9.68	No	No	0	5	4
17	R:R:K16	R:R:T185	10.51	No	No	0	4	2
18	R:R:N17	R:R:T263	7.31	No	No	0	5	3
19	R:R:C18	R:R:C183	7.28	No	No	0	9	1
20	R:R:C19	R:R:C266	7.28	No	No	0	4	7
21	R:R:N171	R:R:V20	10.35	No	No	4	1	2
22	R:R:L176	R:R:V20	4.47	Yes	No	4	4	2
23	R:R:R22	R:R:R90	20.26	No	No	0	3	4
24	R:R:D23	R:R:F25	4.78	No	No	0	4	6
25	R:R:D24	R:R:R90	5.96	No	No	0	4	4
26	R:R:F25	R:R:L274	6.09	No	Yes	0	6	1
27	R:R:L30	R:R:Y87	17.58	No	Yes	0	5	6
28	R:R:P31	R:R:P32	5.84	No	No	0	6	5
29	R:R:P31	R:R:V88	5.3	No	No	0	6	3
30	R:R:L34	R:R:M84	7.07	No	No	0	8	7
31	R:R:L34	R:R:Y87	5.86	No	Yes	0	8	6
32	R:R:E37	R:R:Y284	5.61	No	Yes	0	7	7
33	R:R:F38	R:R:P81	13	No	No	0	7	8
34	R:R:F38	R:R:M84	4.98	No	No	0	7	7
35	R:R:F40	R:R:M288	9.95	No	No	0	6	8
36	R:R:G41	R:R:I77	5.29	No	No	0	8	6
37	R:R:F74	R:R:L42	6.09	No	No	0	7	7
38	R:R:I77	R:R:L42	7.14	No	No	0	6	7
39	R:R:D73	R:R:N45	6.73	Yes	No	0	9	9
40	R:R:I77	R:R:N45	5.66	No	No	0	6	9
41	R:R:N45	R:R:P291	11.4	No	No	0	9	9
42	R:R:L47	R:R:W50	23.92	No	No	0	6	4
43	R:R:F296	R:R:L47	10.96	No	No	0	8	6
44	R:R:F74	R:R:L49	4.87	No	No	0	7	7
45	R:R:F54	R:R:W50	7.02	No	No	0	4	4
46	R:R:H55	R:R:I51	6.63	No	No	0	5	7
47	R:R:F301	R:R:I51	13.82	Yes	No	0	9	7
48	R:R:F52	R:R:W59	6.01	No	No	5	7	6
49	R:R:F52	R:R:F67	9.65	No	Yes	5	7	6
50	R:R:F301	R:R:F52	13.93	Yes	No	0	9	7
51	R:R:C53	R:R:F54	9.78	No	No	0	4	4
52	R:R:F54	R:R:H55	5.66	No	No	0	4	5
53	R:R:L56	R:R:R63	9.72	No	Yes	0	5	7
54	R:R:K60	R:R:S58	9.18	No	No	0	7	6
55	R:R:F67	R:R:W59	9.02	Yes	No	5	6	6
56	R:R:I139	R:R:S61	6.19	No	No	0	7	6
57	R:R:D124	R:R:S62	5.89	No	No	8	8	8
58	R:R:R128	R:R:S62	7.91	No	No	8	8	8
59	R:R:L66	R:R:R63	4.86	No	Yes	0	8	7
60	R:R:R63	R:R:S300	5.27	Yes	No	0	7	5
61	R:R:F301	R:R:R63	4.28	Yes	Yes	0	9	7
62	R:R:A144	R:R:I64	6.5	No	No	0	7	7
63	R:R:F65	R:R:V120	9.18	No	No	0	7	7
64	R:R:L66	R:R:V121	4.47	No	No	0	8	9
65	R:R:L66	R:R:Y295	4.69	No	Yes	0	8	7
66	R:R:F67	R:R:N68	4.83	Yes	Yes	5	6	9
67	R:R:F67	R:R:V71	7.87	Yes	No	0	6	6
68	R:R:F117	R:R:N68	15.71	No	Yes	5	8	9
69	R:R:N68	R:R:S148	8.94	Yes	No	0	9	8
70	R:R:N68	R:R:W152	5.65	Yes	No	5	9	9
71	R:R:D73	R:R:L69	5.43	Yes	No	6	9	9
72	R:R:D290	R:R:L69	6.79	Yes	No	6	9	9
73	R:R:L69	R:R:Y294	4.69	No	Yes	6	9	9
74	R:R:A70	R:R:Y295	5.34	No	Yes	0	8	7
75	R:R:D73	R:R:S287	4.42	Yes	No	0	9	8
76	R:R:D290	R:R:D73	11.98	Yes	Yes	6	9	9
77	R:R:F74	R:R:I78	6.28	No	No	0	7	6
78	R:R:L75	R:R:N110	8.24	No	No	0	6	9
79	R:R:L76	R:R:N110	5.49	No	No	0	7	9
80	R:R:L76	R:R:Y284	5.86	No	Yes	0	7	7
81	R:R:L76	R:R:S287	4.5	No	No	0	7	8
82	R:R:F82	R:R:F95	7.5	No	Yes	0	6	7
83	R:R:L83	R:R:Y87	15.24	No	Yes	0	6	6
84	R:R:L83	R:R:M103	5.65	No	No	0	6	5
85	R:R:D85	R:R:R89	10.72	No	No	3	4	4
86	R:R:D85	R:R:K94	8.3	No	No	3	4	3
87	R:R:D85	R:R:F95	5.97	No	Yes	3	4	7
88	R:R:N86	R:R:W91	5.65	No	Yes	0	5	4
89	R:R:N86	R:R:W93	7.91	No	Yes	0	5	9
90	R:R:W91	R:R:Y87	7.72	Yes	Yes	0	4	6
91	R:R:K94	R:R:R89	9.9	No	No	3	3	4
92	R:R:L176	R:R:W91	4.56	Yes	Yes	4	4	4
93	R:R:S178	R:R:W91	9.88	No	Yes	4	4	4
94	R:R:F277	R:R:W91	12.03	No	Yes	0	5	4
95	R:R:F95	R:R:W93	16.04	Yes	Yes	3	7	9
96	R:R:C100	R:R:W93	7.84	No	Yes	3	9	9
97	R:R:N175	R:R:W93	5.65	No	Yes	0	4	9
98	R:R:C177	R:R:W93	9.14	No	Yes	3	9	9
99	R:R:F95	R:R:K94	14.89	Yes	No	3	7	3
100	R:R:F95	R:R:P99	4.33	Yes	No	0	7	5
101	R:R:D97	R:R:K166	13.83	No	No	0	3	4
102	R:R:D97	R:R:P168	11.27	No	No	0	3	4
103	R:R:I98	R:R:P99	5.08	No	No	0	2	5
104	R:R:I98	R:R:R101	8.77	No	Yes	0	2	6
105	R:R:C100	R:R:P168	5.65	No	No	0	9	4
106	R:R:C100	R:R:C177	7.28	No	No	3	9	9
107	R:R:L102	R:R:R101	8.5	No	Yes	0	5	6
108	R:R:L163	R:R:R101	24.3	No	Yes	0	5	6
109	R:R:K166	R:R:R101	4.95	No	Yes	0	4	6
110	R:R:L107	R:R:M103	5.65	No	No	0	6	5
111	R:R:L104	R:R:S179	6.01	No	No	0	5	4
112	R:R:F105	R:R:M106	6.22	Yes	Yes	7	6	5
113	R:R:F105	R:R:M109	9.95	Yes	Yes	7	6	5
114	R:R:F105	R:R:T159	5.19	Yes	Yes	7	6	7
115	R:R:F105	R:R:L163	17.05	Yes	No	0	6	5
116	R:R:M106	R:R:M109	4.33	Yes	Yes	7	5	5
117	R:R:M106	R:R:N110	7.01	Yes	No	0	5	9
118	R:R:M109	R:R:T155	4.52	Yes	No	0	5	7
119	R:R:M109	R:R:T159	6.02	Yes	Yes	7	5	7
120	R:R:F180	R:R:R111	5.34	Yes	Yes	1	3	8
121	R:R:F193	R:R:R111	4.28	Yes	Yes	1	6	8
122	R:R:E196	R:R:R111	5.82	No	Yes	0	5	8
123	R:R:R111	R:R:T283	9.06	Yes	Yes	0	8	8
124	R:R:M192	R:R:Q112	8.16	No	No	0	5	7
125	R:R:E196	R:R:I115	5.47	No	No	0	5	8
126	R:R:F244	R:R:I115	10.05	Yes	No	0	8	8
127	R:R:I116	R:R:L151	4.28	No	No	0	5	7
128	R:R:F117	R:R:L151	4.87	No	No	0	8	7
129	R:R:F117	R:R:W152	12.03	No	No	5	8	9
130	R:R:F240	R:R:L118	7.31	Yes	No	0	9	9
131	R:R:L118	R:R:Y294	7.03	No	Yes	0	9	9
132	R:R:P200	R:R:T119	6.99	No	No	0	9	7
133	R:R:I203	R:R:T119	4.56	No	No	0	7	7
134	R:R:I204	R:R:T119	9.12	No	No	0	8	7
135	R:R:R125	R:R:V121	6.54	No	No	0	9	9
136	R:R:D124	R:R:R128	11.91	No	No	8	8	8
137	R:R:I233	R:R:R125	5.01	No	No	0	7	9
138	R:R:R125	R:R:Y294	6.17	No	Yes	0	9	9
139	R:R:F127	R:R:Y126	5.16	Yes	Yes	2	5	7
140	R:R:V130	R:R:Y126	12.62	Yes	Yes	2	8	7
141	R:R:H131	R:R:Y126	7.62	Yes	Yes	2	7	7
142	R:R:F206	R:R:Y126	7.22	No	Yes	2	4	7
143	R:R:C207	R:R:Y126	9.41	No	Yes	0	8	7
144	R:R:R210	R:R:Y126	12.35	No	Yes	2	4	7
145	R:R:F127	R:R:H131	5.66	Yes	Yes	2	5	7
146	R:R:F127	R:R:H134	11.31	Yes	Yes	2	5	4
147	R:R:F127	R:R:L136	8.53	Yes	No	2	5	4
148	R:R:N137	R:R:R128	4.82	No	No	0	4	8
149	R:R:I211	R:R:V129	7.68	No	No	0	8	8
150	R:R:H131	R:R:V130	8.3	Yes	Yes	2	7	8
151	R:R:R210	R:R:V130	5.23	No	Yes	2	4	8
152	R:R:H134	R:R:L136	9	Yes	No	2	4	4
153	R:R:S140	R:R:T143	4.8	No	No	0	6	3
154	R:R:I146	R:R:R142	7.52	No	No	0	3	4
155	R:R:L158	R:R:W188	6.83	No	No	0	5	5
156	R:R:K164	R:R:V160	4.55	No	No	0	4	4
157	R:R:H161	R:R:L162	12.86	No	No	1	7	4
158	R:R:H161	R:R:H189	4.78	No	Yes	1	7	5
159	R:R:H189	R:R:L162	9	Yes	No	1	5	4
160	R:R:I169	R:R:M167	7.29	No	No	0	1	3
161	R:R:N175	R:R:P168	4.89	No	No	0	4	4
162	R:R:I169	R:R:L176	5.71	No	Yes	0	1	4
163	R:R:L176	R:R:N171	6.87	Yes	No	4	4	1
164	R:R:L176	R:R:S178	7.51	Yes	No	4	4	4
165	R:R:H189	R:R:S179	8.37	Yes	No	0	5	4
166	R:R:F180	R:R:H189	16.97	Yes	Yes	1	3	5
167	R:R:F180	R:R:F193	11.79	Yes	Yes	1	3	6
168	R:R:F180	R:R:R251	7.48	Yes	Yes	1	3	5
169	R:R:F180	R:R:F276	6.43	Yes	Yes	1	3	4
170	R:R:I182	R:R:I254	7.36	No	No	0	3	4
171	R:R:I182	R:R:Y269	6.04	No	No	0	3	2
172	R:R:D273	R:R:I182	8.4	No	No	0	4	3
173	R:R:H184	R:R:L258	7.71	No	No	0	3	3
174	R:R:Q187	R:R:T185	5.67	No	No	0	2	2
175	R:R:E190	R:R:Q187	5.1	No	No	0	4	2
176	R:R:M192	R:R:W188	6.98	No	No	0	5	5
177	R:R:E190	R:R:R251	13.96	No	Yes	1	4	5
178	R:R:E190	R:R:F255	11.66	No	Yes	1	4	5
179	R:R:F193	R:R:R251	6.41	Yes	Yes	1	6	5
180	R:R:I252	R:R:L194	4.28	No	No	0	6	4
181	R:R:F197	R:R:F198	6.43	Yes	No	0	8	5
182	R:R:F197	R:R:L201	6.09	Yes	No	0	8	7
183	R:R:F197	R:R:F240	4.29	Yes	Yes	0	8	9
184	R:R:F197	R:R:L245	6.09	Yes	No	0	8	6
185	R:R:F197	R:R:V248	10.49	Yes	No	0	8	8
186	R:R:I203	R:R:L199	4.28	No	No	0	7	4
187	R:R:F240	R:R:I204	5.02	Yes	No	0	9	8
188	R:R:F206	R:R:R210	9.62	No	No	2	4	4
189	R:R:I212	R:R:R216	5.01	No	No	0	5	4
190	R:R:I212	R:R:I230	4.42	No	No	0	5	6
191	R:R:Q217	R:R:W213	8.76	No	No	0	5	3
192	R:R:I230	R:R:L215	4.28	No	No	0	6	8
193	R:R:D221	R:R:R216	7.15	No	No	0	3	4
194	R:R:H223	R:R:K225	11.79	No	No	0	4	5
195	R:R:I230	R:R:K227	5.82	No	No	0	6	4
196	R:R:F232	R:R:R228	5.34	No	No	0	7	7
197	R:R:P299	R:R:R228	4.32	No	No	0	5	7
198	R:R:F232	R:R:S297	7.93	No	No	0	7	6
199	R:R:V236	R:R:Y294	11.36	No	Yes	0	8	9
200	R:R:F240	R:R:F244	7.5	Yes	Yes	0	9	8
201	R:R:C243	R:R:M285	6.48	No	No	0	8	5
202	R:R:C243	R:R:N286	6.3	No	No	0	8	9
203	R:R:F244	R:R:T283	5.19	Yes	Yes	0	8	8
204	R:R:F244	R:R:N286	13.29	Yes	No	0	8	9
205	R:R:L245	R:R:V249	4.47	No	No	0	6	6
206	R:R:F282	R:R:P246	7.22	Yes	No	0	7	9
207	R:R:I254	R:R:R251	11.27	No	Yes	0	4	5
208	R:R:F255	R:R:R251	5.34	Yes	Yes	1	5	5
209	R:R:F276	R:R:R251	13.9	Yes	Yes	1	4	5
210	R:R:T260	R:R:W256	4.85	No	No	0	1	4
211	R:R:Q264	R:R:T263	5.67	No	No	0	3	3
212	R:R:N265	R:R:V268	4.43	No	No	0	5	1
213	R:R:E267	R:R:R270	4.65	No	No	0	2	1
214	R:R:V268	R:R:Y269	5.05	No	No	0	1	2
215	R:R:L274	R:R:S271	6.01	Yes	No	0	1	3
216	R:R:D273	R:R:F277	8.36	No	No	0	4	5
217	R:R:I278	R:R:L274	4.28	No	Yes	0	6	1
218	R:R:F276	R:R:F277	11.79	Yes	No	0	4	5
219	R:R:F282	R:R:T279	5.19	Yes	No	0	7	7
220	R:R:L280	R:R:T283	4.42	No	Yes	0	5	8
221	R:R:F282	R:R:M285	6.22	Yes	No	0	7	5
222	R:R:T283	R:R:Y284	6.24	Yes	Yes	0	8	7
223	R:R:D290	R:R:N286	8.08	Yes	No	0	9	9
224	R:R:D290	R:R:Y294	8.05	Yes	Yes	6	9	9
225	R:R:F301	R:R:Y295	5.16	Yes	Yes	0	9	7
226	R:R:F296	R:R:F301	4.29	No	Yes	0	8	9
227	R:R:P299	R:R:S298	5.34	No	No	0	5	8
228	R:R:S298	R:R:S300	4.89	No	No	0	8	5
229	R:R:L215	R:R:M220	4.24	No	No	0	8	3
230	R:R:L289	R:R:M288	4.24	No	No	0	7	8
231	R:R:C19	R:R:F21	4.19	No	No	0	4	2
232	R:R:A174	R:R:R22	4.15	No	No	0	2	3
233	R:R:L34	R:R:L80	4.15	No	No	0	8	8
234	R:R:L201	R:R:L205	4.15	No	No	0	7	4
235	R:R:G44	R:R:P291	4.06	No	No	0	7	9
236	R:R:G96	R:R:P99	4.06	No	No	0	7	5
237	R:R:A48	R:R:Y295	4	No	Yes	0	9	7
238	R:R:F193	R:R:S247	3.96	Yes	No	0	6	6
239	R:R:F282	R:R:S281	3.96	Yes	No	0	7	6
240	R:R:F276	R:R:V250	3.93	Yes	No	0	4	5
241	R:R:R90	R:R:V27	3.92	No	No	0	4	3
242	R:R:R253	R:R:V250	3.92	No	No	0	5	5
243	R:R:E196	R:R:Q112	3.82	No	No	0	5	7
244	R:R:V293	R:R:Y294	3.79	No	Yes	0	8	9
245	R:R:F65	R:R:I147	3.77	No	No	0	7	5
246	R:R:F25	R:R:K28	3.72	No	No	0	6	3
247	R:R:F40	R:R:L36	3.65	No	No	0	6	4
248	R:R:F255	R:R:L194	3.65	Yes	No	0	5	4
249	R:R:F255	R:R:L258	3.65	Yes	No	0	5	3
250	R:R:G113	R:R:T155	3.64	No	No	0	7	7
251	R:R:D273	R:R:F21	3.58	No	No	0	4	2
252	R:R:D92	R:R:R22	3.57	No	No	0	4	3
253	R:R:D92	R:R:R89	3.57	No	No	0	4	4
254	R:R:I26	R:R:W91	3.52	No	Yes	0	5	4
255	R:R:L257	R:R:Y269	3.52	No	No	0	3	2
256	R:R:G35	R:R:M84	3.49	No	No	0	5	7
257	R:R:C18	R:R:S181	3.44	No	No	0	9	4
258	R:R:A144	R:R:S61	3.42	No	No	0	7	6
259	R:R:C207	R:R:V123	3.42	No	No	0	8	6
260	R:R:C79	R:R:M106	3.24	No	Yes	0	6	5
261	R:R:S281	R:R:V33	3.23	No	No	0	6	5
262	R:R:S214	R:R:V129	3.23	No	No	0	5	8
263	R:R:S214	R:R:V130	3.23	No	Yes	0	5	8
264	R:R:V235	R:R:V293	3.21	No	No	0	5	8
265	R:R:S261	R:R:T260	3.2	No	No	0	3	1
266	R:R:G262	R:R:H184	3.18	No	No	0	4	3
267	R:R:I64	R:R:S148	3.1	No	No	0	7	8
268	R:R:I233	R:R:S208	3.1	No	No	0	7	8
269	R:R:K28	R:R:V29	3.04	No	No	0	3	5
270	R:R:I156	R:R:T159	3.04	No	Yes	0	4	7
271	R:R:L151	R:R:V120	2.98	No	No	0	7	7
272	R:R:L215	R:R:V129	2.98	No	No	0	8	8
273	R:R:L289	R:R:V239	2.98	No	No	0	7	7
274	R:R:L245	R:R:V241	2.98	No	No	0	6	5
275	R:R:D73	R:R:S114	2.94	Yes	No	0	9	9
276	R:R:I238	R:R:I242	2.94	No	No	0	5	5
277	R:R:I212	R:R:M234	2.92	No	No	0	5	4
278	R:R:I226	R:R:M220	2.92	No	No	0	6	3
279	R:R:K15	R:R:K16	2.87	No	No	0	3	4
280	R:R:I26	R:R:L274	2.85	No	Yes	0	5	1
281	R:R:I154	R:R:L150	2.85	No	No	0	5	4
282	R:R:L289	R:R:M285	2.83	No	No	0	7	5
283	R:R:C266	R:R:F10	2.79	No	No	0	7	7
284	R:R:P31	R:R:Y87	2.78	No	Yes	0	6	6
285	R:R:A191	R:R:F186	2.77	No	No	0	3	4
286	R:R:L195	R:R:L199	2.77	No	No	0	4	4
287	R:R:H223	R:R:I226	2.65	No	No	0	4	6
288	R:R:E267	R:R:N265	2.63	No	No	0	2	5
289	R:R:R253	R:R:V272	2.62	No	No	0	5	4
290	R:R:A72	R:R:W152	2.59	No	No	0	8	9
291	R:R:A191	R:R:W188	2.59	No	No	0	3	5
292	R:R:G172	R:R:G173	2.11	No	No	0	3	4
293	R:R:G153	R:R:I156	1.76	No	No	0	4	4
294	R:R:G44	R:R:L43	1.71	No	No	0	7	4
295	R:R:G202	R:R:L201	1.71	No	No	0	3	7
296	R:R:A237	R:R:S208	1.71	No	No	0	7	8
297	R:R:C19	R:R:T263	1.69	No	No	0	4	3
298	R:R:A108	R:R:T159	1.68	No	Yes	0	4	7
299	R:R:K225	R:R:P299	1.67	No	No	0	5	5
300	R:R:A122	R:R:I204	1.62	No	No	0	9	8
301	R:R:V292	R:R:V293	1.6	No	No	0	6	8
302	R:R:I156	R:R:V160	1.54	No	No	0	4	4
303	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
304	R:R:H133	R:R:P132	1.53	No	No	0	6	8
305	R:R:I139	R:R:T143	1.52	No	No	0	7	3
306	R:R:I147	R:R:T143	1.52	No	No	0	5	3
307	R:R:N141	R:R:S61	1.49	No	No	0	2	6
308	R:R:I116	R:R:I154	1.47	No	No	0	5	5
309	R:R:A135	R:R:H134	1.46	No	Yes	0	5	4
310	R:R:A224	R:R:H223	1.46	No	No	0	3	4
311	R:R:K138	R:R:N137	1.4	No	No	0	4	4
312	R:R:H259	R:R:T260	1.37	No	No	0	1	1
313	R:R:F232	R:R:T231	1.3	No	No	0	7	6
314	R:R:H134	R:R:N137	1.28	Yes	No	0	4	4
315	R:R:F40	R:R:I39	1.26	No	No	0	6	5
316	R:R:M220	R:R:R218	1.24	No	No	0	3	5
317	R:R:Q217	R:R:R218	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.64714	7	1	0
2	R:R:R63	6.0325	4	0	7
3	R:R:F67	7.8425	4	5	6
4	R:R:N68	8.7825	4	5	9
5	R:R:D73	6.3	5	6	9
6	R:R:Y87	9.836	5	0	6
7	R:R:W91	7.22667	6	4	4
8	R:R:W93	9.316	5	3	9
9	R:R:F95	9.746	5	3	7
10	R:R:R101	11.63	4	0	6
11	R:R:F105	9.6025	4	7	6
12	R:R:M106	5.2	4	7	5
13	R:R:M109	6.205	4	7	5
14	R:R:R111	6.928	5	1	8
15	R:R:Y126	9.06333	6	2	7
16	R:R:F127	7.665	4	2	5
17	R:R:V130	7.345	4	2	8
18	R:R:H131	5.7775	4	2	7
19	R:R:H134	5.7625	4	2	4
20	R:R:T159	3.9825	4	7	7
21	R:R:L176	5.824	5	4	4
22	R:R:F180	9.695	6	1	3
23	R:R:H189	9.78	4	1	5
24	R:R:F193	6.61	4	1	6
25	R:R:F197	6.678	5	0	8
26	R:R:F240	6.03	4	0	9
27	R:R:F244	9.0075	4	0	8
28	R:R:R251	9.72667	6	1	5
29	R:R:F255	6.075	4	1	5
30	R:R:L274	4.8075	4	0	1
31	R:R:F276	9.0125	4	1	4
32	R:R:F282	5.6475	4	0	7
33	R:R:T283	6.2275	4	0	8
34	R:R:Y284	6.33	4	0	7
35	R:R:D290	8.725	4	6	9
36	R:R:Y294	6.84833	6	6	9
37	R:R:Y295	4.7975	4	0	7
38	R:R:F301	8.296	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F180	R:R:F276	17.3264	6.43	Yes	Yes	1	3	4
2	R:R:F276	R:R:F277	17.3906	11.79	Yes	No	0	4	5
3	L:L:?1	R:R:L83	61.2973	5.13	Yes	No	0	0	6
4	R:R:L83	R:R:Y87	59.4782	15.24	No	Yes	0	6	6
5	R:R:W91	R:R:Y87	48.6197	7.72	Yes	Yes	0	4	6
6	R:R:L176	R:R:W91	17.7264	4.56	Yes	Yes	4	4	4
7	R:R:I169	R:R:L176	10.9261	5.71	No	Yes	0	1	4
8	R:R:N86	R:R:W91	32.8313	5.65	No	Yes	0	5	4
9	R:R:N86	R:R:W93	31.5059	7.91	No	Yes	0	5	9
10	R:R:F95	R:R:W93	25.4902	16.04	Yes	Yes	3	7	9
11	R:R:D85	R:R:F95	13.0328	5.97	No	Yes	3	4	7
12	R:R:D85	R:R:R89	11.4095	10.72	No	No	3	4	4
13	R:R:D92	R:R:R89	19.5648	3.57	No	No	0	4	4
14	R:R:D92	R:R:R22	16.3081	3.57	No	No	0	4	3
15	R:R:F95	R:R:K94	13.0328	14.89	Yes	No	3	7	3
16	R:R:K94	R:R:R89	11.4095	9.9	No	No	3	3	4
17	R:R:I26	R:R:W91	11.2509	3.52	No	Yes	0	5	4
18	L:L:?1	R:R:Y284	34.2926	7.61	Yes	Yes	0	0	7
19	L:L:?1	R:R:R111	17.2514	10.14	Yes	Yes	1	0	8
20	R:R:R111	R:R:T283	44.5201	9.06	Yes	Yes	0	8	8
21	R:R:F244	R:R:T283	78.6659	5.19	Yes	Yes	0	8	8
22	R:R:F244	R:R:N286	40.3825	13.29	Yes	No	0	8	9
23	L:L:?1	R:R:L280	16.5418	11.55	Yes	No	0	0	5
24	R:R:L280	R:R:T283	16.7131	4.42	No	Yes	0	5	8
25	R:R:T283	R:R:Y284	18.1069	6.24	Yes	Yes	0	8	7
26	R:R:L76	R:R:Y284	19.3826	5.86	No	Yes	0	7	7
27	R:R:L76	R:R:S287	28.277	4.5	No	No	0	7	8
28	R:R:D73	R:R:S287	28.4052	4.42	Yes	No	0	9	8
29	R:R:F240	R:R:F244	41.1858	7.5	Yes	Yes	0	9	8
30	R:R:F240	R:R:L118	38.0007	7.31	Yes	No	0	9	9
31	R:R:L118	R:R:Y294	37.8649	7.03	No	Yes	0	9	9
32	R:R:R125	R:R:Y294	100	6.17	No	Yes	0	9	9
33	R:R:R125	R:R:V121	97.4309	6.54	No	No	0	9	9
34	R:R:L66	R:R:V121	96.7871	4.47	No	No	0	8	9
35	R:R:L66	R:R:R63	68.3406	4.86	No	Yes	0	8	7
36	R:R:F301	R:R:R63	27.2519	4.28	Yes	Yes	0	9	7
37	R:R:D290	R:R:N286	38.0623	8.08	Yes	No	0	9	9
38	R:R:D290	R:R:Y294	51.5963	8.05	Yes	Yes	6	9	9
39	R:R:D290	R:R:D73	15.5285	11.98	Yes	Yes	6	9	9
40	R:R:D73	R:R:L69	14.7388	5.43	Yes	No	6	9	9
41	R:R:L69	R:R:Y294	14.7185	4.69	No	Yes	6	9	9
42	R:R:L66	R:R:Y295	28.0779	4.69	No	Yes	0	8	7
43	R:R:F301	R:R:Y295	25.8125	5.16	Yes	Yes	0	9	7
44	R:R:F301	R:R:F52	40.2729	13.93	Yes	No	0	9	7
45	R:R:F52	R:R:F67	37.2726	9.65	No	Yes	5	7	6
46	R:R:F67	R:R:N68	34.0885	4.83	Yes	Yes	5	6	9
47	R:R:N68	R:R:S148	13.0294	8.94	Yes	No	0	9	8
48	R:R:I64	R:R:S148	11.4036	3.1	No	No	0	7	8
49	R:R:R63	R:R:S300	42.9204	5.27	Yes	No	0	7	5
50	R:R:S298	R:R:S300	42.2201	4.89	No	No	0	8	5
51	R:R:P299	R:R:S298	41.4456	5.34	No	No	0	5	8
52	R:R:K225	R:R:P299	37.6152	1.67	No	No	0	5	5
53	R:R:H223	R:R:K225	36.9039	11.79	No	No	0	4	5
54	R:R:H223	R:R:I226	35.3296	2.65	No	No	0	4	6
55	R:R:I226	R:R:M220	34.5398	2.92	No	No	0	6	3
56	R:R:L215	R:R:M220	31.3641	4.24	No	No	0	8	3
57	R:R:L215	R:R:V129	25.8024	2.98	No	No	0	8	8
58	R:R:S214	R:R:V129	24.1875	3.23	No	No	0	5	8
59	R:R:S214	R:R:V130	23.3725	3.23	No	Yes	0	5	8
60	R:R:V130	R:R:Y126	10.8223	12.62	Yes	Yes	2	8	7
61	R:R:F127	R:R:H134	11.7841	11.31	Yes	Yes	2	5	4
62	R:R:H131	R:R:V130	10.0613	8.3	Yes	Yes	2	7	8
63	R:R:F117	R:R:N68	16.2676	15.71	No	Yes	5	8	9
64	R:R:F117	R:R:L151	14.662	4.87	No	No	0	8	7
65	R:R:L76	R:R:N110	14.6156	5.49	No	No	0	7	9
66	R:R:M106	R:R:N110	13.9406	7.01	Yes	No	0	5	9
67	R:R:F277	R:R:W91	14.7	12.03	No	Yes	0	5	4
68	R:R:F180	R:R:R111	22.5878	5.34	Yes	Yes	1	3	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	5.13	1	Yes	No	0	6	0	1
L:L:?1	R:R:L107	8.98	1	Yes	No	0	6	0	1
L:L:?1	R:R:R111	10.14	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S179	6.96	1	Yes	No	0	4	0	1
L:L:?1	R:R:F180	10.16	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:L280	11.55	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	7.61	1	Yes	Yes	0	7	0	1
R:R:E37	R:R:Y284	5.61	0	No	Yes	7	7	2	1
R:R:L76	R:R:Y284	5.86	0	No	Yes	7	7	2	1
R:R:L83	R:R:Y87	15.24	0	No	Yes	6	6	1	2
R:R:L83	R:R:M103	5.65	0	No	No	6	5	1	2
R:R:L107	R:R:M103	5.65	0	No	No	6	5	1	2
R:R:L104	R:R:S179	6.01	0	No	No	5	4	2	1
R:R:F180	R:R:R111	5.34	1	Yes	Yes	3	8	1	1
R:R:F193	R:R:R111	4.28	1	Yes	Yes	6	8	2	1
R:R:E196	R:R:R111	5.82	0	No	Yes	5	8	2	1
R:R:R111	R:R:T283	9.06	1	Yes	Yes	8	8	1	2
R:R:H189	R:R:S179	8.37	1	Yes	No	5	4	2	1
R:R:F180	R:R:H189	16.97	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F193	11.79	1	Yes	Yes	3	6	1	2
R:R:F180	R:R:R251	7.48	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	6.43	1	Yes	Yes	3	4	1	2
R:R:F193	R:R:R251	6.41	1	Yes	Yes	6	5	2	2
R:R:F276	R:R:R251	13.9	1	Yes	Yes	4	5	2	2
R:R:L280	R:R:T283	4.42	0	No	Yes	5	8	1	2
R:R:T283	R:R:Y284	6.24	0	Yes	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IJA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.28
Number of Linked Nodes	284
Number of Links	317
Number of Hubs	38
Number of Links mediated by Hubs	137
Number of Communities	8
Number of Nodes involved in Communities	49
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	157312
Length Of Smallest Path	3
Average Path Length	20.7127
Length of Longest Path	40
Minimum Path Strength	1.205
Average Path Strength	6.90806
Maximum Path Strength	20.675
Minimum Path Correlation	0.7
Average Path Correlation	0.91984
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	32.651
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.3842
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NIO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NIO
Name	Niacin
Synonyms	β-pyridinecarboxylic acid
Identifier
Formula	C6 H5 N O2
Molecular Weight	123.109
SMILES
PubChem	938
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	14
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8IJA_nogp_Chain_R D H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	9JKY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.72	2025-10-29	To be published
	9JKY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.72	2025-10-29	To be published
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9KT7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.73	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.73	2025-12-10	10.1021/acs.jmedchem.4c02567

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