psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	5.13	Yes	No	0	0	6
2	L:L:?1	R:R:L107	8.98	Yes	No	0	0	6
3	L:L:?1	R:R:R111	10.14	Yes	Yes	1	0	8
4	L:L:?1	R:R:S179	6.96	Yes	No	0	0	4
5	L:L:?1	R:R:F180	10.16	Yes	Yes	1	0	3
6	L:L:?1	R:R:L280	11.55	Yes	No	0	0	5
7	L:L:?1	R:R:Y284	7.61	Yes	Yes	0	0	7
8	R:R:D8	R:R:F10	7.17	No	No	0	6	7
9	R:R:F21	R:R:H9	19.23	No	No	0	2	6
10	R:R:L11	R:R:V20	4.47	No	No	4	8	2
11	R:R:L11	R:R:N171	6.87	No	No	4	8	1
12	R:R:E12	R:R:N17	9.2	No	No	0	5	5
13	R:R:D14	R:R:I13	5.6	No	No	0	5	3
14	R:R:C18	R:R:I13	4.91	No	No	0	9	3
15	R:R:I13	R:R:I169	14.72	No	No	0	3	1
16	R:R:D14	R:R:K165	9.68	No	No	0	5	4
17	R:R:K16	R:R:T185	10.51	No	No	0	4	2
18	R:R:N17	R:R:T263	7.31	No	No	0	5	3
19	R:R:C18	R:R:C183	7.28	No	No	0	9	1
20	R:R:C19	R:R:C266	7.28	No	No	0	4	7
21	R:R:N171	R:R:V20	10.35	No	No	4	1	2
22	R:R:L176	R:R:V20	4.47	Yes	No	4	4	2
23	R:R:R22	R:R:R90	20.26	No	No	0	3	4
24	R:R:D23	R:R:F25	4.78	No	No	0	4	6
25	R:R:D24	R:R:R90	5.96	No	No	0	4	4
26	R:R:F25	R:R:L274	6.09	No	Yes	0	6	1
27	R:R:L30	R:R:Y87	17.58	No	Yes	0	5	6
28	R:R:P31	R:R:P32	5.84	No	No	0	6	5
29	R:R:P31	R:R:V88	5.3	No	No	0	6	3
30	R:R:L34	R:R:M84	7.07	No	No	0	8	7
31	R:R:L34	R:R:Y87	5.86	No	Yes	0	8	6
32	R:R:E37	R:R:Y284	5.61	No	Yes	0	7	7
33	R:R:F38	R:R:P81	13	No	No	0	7	8
34	R:R:F38	R:R:M84	4.98	No	No	0	7	7
35	R:R:F40	R:R:M288	9.95	No	No	0	6	8
36	R:R:G41	R:R:I77	5.29	No	No	0	8	6
37	R:R:F74	R:R:L42	6.09	No	No	0	7	7
38	R:R:I77	R:R:L42	7.14	No	No	0	6	7
39	R:R:D73	R:R:N45	6.73	Yes	No	0	9	9
40	R:R:I77	R:R:N45	5.66	No	No	0	6	9
41	R:R:N45	R:R:P291	11.4	No	No	0	9	9
42	R:R:L47	R:R:W50	23.92	No	No	0	6	4
43	R:R:F296	R:R:L47	10.96	No	No	0	8	6
44	R:R:F74	R:R:L49	4.87	No	No	0	7	7
45	R:R:F54	R:R:W50	7.02	No	No	0	4	4
46	R:R:H55	R:R:I51	6.63	No	No	0	5	7
47	R:R:F301	R:R:I51	13.82	Yes	No	0	9	7
48	R:R:F52	R:R:W59	6.01	No	No	5	7	6
49	R:R:F52	R:R:F67	9.65	No	Yes	5	7	6
50	R:R:F301	R:R:F52	13.93	Yes	No	0	9	7
51	R:R:C53	R:R:F54	9.78	No	No	0	4	4
52	R:R:F54	R:R:H55	5.66	No	No	0	4	5
53	R:R:L56	R:R:R63	9.72	No	Yes	0	5	7
54	R:R:K60	R:R:S58	9.18	No	No	0	7	6
55	R:R:F67	R:R:W59	9.02	Yes	No	5	6	6
56	R:R:I139	R:R:S61	6.19	No	No	0	7	6
57	R:R:D124	R:R:S62	5.89	No	No	8	8	8
58	R:R:R128	R:R:S62	7.91	No	No	8	8	8
59	R:R:L66	R:R:R63	4.86	No	Yes	0	8	7
60	R:R:R63	R:R:S300	5.27	Yes	No	0	7	5
61	R:R:F301	R:R:R63	4.28	Yes	Yes	0	9	7
62	R:R:A144	R:R:I64	6.5	No	No	0	7	7
63	R:R:F65	R:R:V120	9.18	No	No	0	7	7
64	R:R:L66	R:R:V121	4.47	No	No	0	8	9
65	R:R:L66	R:R:Y295	4.69	No	Yes	0	8	7
66	R:R:F67	R:R:N68	4.83	Yes	Yes	5	6	9
67	R:R:F67	R:R:V71	7.87	Yes	No	0	6	6
68	R:R:F117	R:R:N68	15.71	No	Yes	5	8	9
69	R:R:N68	R:R:S148	8.94	Yes	No	0	9	8
70	R:R:N68	R:R:W152	5.65	Yes	No	5	9	9
71	R:R:D73	R:R:L69	5.43	Yes	No	6	9	9
72	R:R:D290	R:R:L69	6.79	Yes	No	6	9	9
73	R:R:L69	R:R:Y294	4.69	No	Yes	6	9	9
74	R:R:A70	R:R:Y295	5.34	No	Yes	0	8	7
75	R:R:D73	R:R:S287	4.42	Yes	No	0	9	8
76	R:R:D290	R:R:D73	11.98	Yes	Yes	6	9	9
77	R:R:F74	R:R:I78	6.28	No	No	0	7	6
78	R:R:L75	R:R:N110	8.24	No	No	0	6	9
79	R:R:L76	R:R:N110	5.49	No	No	0	7	9
80	R:R:L76	R:R:Y284	5.86	No	Yes	0	7	7
81	R:R:L76	R:R:S287	4.5	No	No	0	7	8
82	R:R:F82	R:R:F95	7.5	No	Yes	0	6	7
83	R:R:L83	R:R:Y87	15.24	No	Yes	0	6	6
84	R:R:L83	R:R:M103	5.65	No	No	0	6	5
85	R:R:D85	R:R:R89	10.72	No	No	3	4	4
86	R:R:D85	R:R:K94	8.3	No	No	3	4	3
87	R:R:D85	R:R:F95	5.97	No	Yes	3	4	7
88	R:R:N86	R:R:W91	5.65	No	Yes	0	5	4
89	R:R:N86	R:R:W93	7.91	No	Yes	0	5	9
90	R:R:W91	R:R:Y87	7.72	Yes	Yes	0	4	6
91	R:R:K94	R:R:R89	9.9	No	No	3	3	4
92	R:R:L176	R:R:W91	4.56	Yes	Yes	4	4	4
93	R:R:S178	R:R:W91	9.88	No	Yes	4	4	4
94	R:R:F277	R:R:W91	12.03	No	Yes	0	5	4
95	R:R:F95	R:R:W93	16.04	Yes	Yes	3	7	9
96	R:R:C100	R:R:W93	7.84	No	Yes	3	9	9
97	R:R:N175	R:R:W93	5.65	No	Yes	0	4	9
98	R:R:C177	R:R:W93	9.14	No	Yes	3	9	9
99	R:R:F95	R:R:K94	14.89	Yes	No	3	7	3
100	R:R:F95	R:R:P99	4.33	Yes	No	0	7	5
101	R:R:D97	R:R:K166	13.83	No	No	0	3	4
102	R:R:D97	R:R:P168	11.27	No	No	0	3	4
103	R:R:I98	R:R:P99	5.08	No	No	0	2	5
104	R:R:I98	R:R:R101	8.77	No	Yes	0	2	6
105	R:R:C100	R:R:P168	5.65	No	No	0	9	4
106	R:R:C100	R:R:C177	7.28	No	No	3	9	9
107	R:R:L102	R:R:R101	8.5	No	Yes	0	5	6
108	R:R:L163	R:R:R101	24.3	No	Yes	0	5	6
109	R:R:K166	R:R:R101	4.95	No	Yes	0	4	6
110	R:R:L107	R:R:M103	5.65	No	No	0	6	5
111	R:R:L104	R:R:S179	6.01	No	No	0	5	4
112	R:R:F105	R:R:M106	6.22	Yes	Yes	7	6	5
113	R:R:F105	R:R:M109	9.95	Yes	Yes	7	6	5
114	R:R:F105	R:R:T159	5.19	Yes	Yes	7	6	7
115	R:R:F105	R:R:L163	17.05	Yes	No	0	6	5
116	R:R:M106	R:R:M109	4.33	Yes	Yes	7	5	5
117	R:R:M106	R:R:N110	7.01	Yes	No	0	5	9
118	R:R:M109	R:R:T155	4.52	Yes	No	0	5	7
119	R:R:M109	R:R:T159	6.02	Yes	Yes	7	5	7
120	R:R:F180	R:R:R111	5.34	Yes	Yes	1	3	8
121	R:R:F193	R:R:R111	4.28	Yes	Yes	1	6	8
122	R:R:E196	R:R:R111	5.82	No	Yes	0	5	8
123	R:R:R111	R:R:T283	9.06	Yes	Yes	0	8	8
124	R:R:M192	R:R:Q112	8.16	No	No	0	5	7
125	R:R:E196	R:R:I115	5.47	No	No	0	5	8
126	R:R:F244	R:R:I115	10.05	Yes	No	0	8	8
127	R:R:I116	R:R:L151	4.28	No	No	0	5	7
128	R:R:F117	R:R:L151	4.87	No	No	0	8	7
129	R:R:F117	R:R:W152	12.03	No	No	5	8	9
130	R:R:F240	R:R:L118	7.31	Yes	No	0	9	9
131	R:R:L118	R:R:Y294	7.03	No	Yes	0	9	9
132	R:R:P200	R:R:T119	6.99	No	No	0	9	7
133	R:R:I203	R:R:T119	4.56	No	No	0	7	7
134	R:R:I204	R:R:T119	9.12	No	No	0	8	7
135	R:R:R125	R:R:V121	6.54	No	No	0	9	9
136	R:R:D124	R:R:R128	11.91	No	No	8	8	8
137	R:R:I233	R:R:R125	5.01	No	No	0	7	9
138	R:R:R125	R:R:Y294	6.17	No	Yes	0	9	9
139	R:R:F127	R:R:Y126	5.16	Yes	Yes	2	5	7
140	R:R:V130	R:R:Y126	12.62	Yes	Yes	2	8	7
141	R:R:H131	R:R:Y126	7.62	Yes	Yes	2	7	7
142	R:R:F206	R:R:Y126	7.22	No	Yes	2	4	7
143	R:R:C207	R:R:Y126	9.41	No	Yes	0	8	7
144	R:R:R210	R:R:Y126	12.35	No	Yes	2	4	7
145	R:R:F127	R:R:H131	5.66	Yes	Yes	2	5	7
146	R:R:F127	R:R:H134	11.31	Yes	Yes	2	5	4
147	R:R:F127	R:R:L136	8.53	Yes	No	2	5	4
148	R:R:N137	R:R:R128	4.82	No	No	0	4	8
149	R:R:I211	R:R:V129	7.68	No	No	0	8	8
150	R:R:H131	R:R:V130	8.3	Yes	Yes	2	7	8
151	R:R:R210	R:R:V130	5.23	No	Yes	2	4	8
152	R:R:H134	R:R:L136	9	Yes	No	2	4	4
153	R:R:S140	R:R:T143	4.8	No	No	0	6	3
154	R:R:I146	R:R:R142	7.52	No	No	0	3	4
155	R:R:L158	R:R:W188	6.83	No	No	0	5	5
156	R:R:K164	R:R:V160	4.55	No	No	0	4	4
157	R:R:H161	R:R:L162	12.86	No	No	1	7	4
158	R:R:H161	R:R:H189	4.78	No	Yes	1	7	5
159	R:R:H189	R:R:L162	9	Yes	No	1	5	4
160	R:R:I169	R:R:M167	7.29	No	No	0	1	3
161	R:R:N175	R:R:P168	4.89	No	No	0	4	4
162	R:R:I169	R:R:L176	5.71	No	Yes	0	1	4
163	R:R:L176	R:R:N171	6.87	Yes	No	4	4	1
164	R:R:L176	R:R:S178	7.51	Yes	No	4	4	4
165	R:R:H189	R:R:S179	8.37	Yes	No	0	5	4
166	R:R:F180	R:R:H189	16.97	Yes	Yes	1	3	5
167	R:R:F180	R:R:F193	11.79	Yes	Yes	1	3	6
168	R:R:F180	R:R:R251	7.48	Yes	Yes	1	3	5
169	R:R:F180	R:R:F276	6.43	Yes	Yes	1	3	4
170	R:R:I182	R:R:I254	7.36	No	No	0	3	4
171	R:R:I182	R:R:Y269	6.04	No	No	0	3	2
172	R:R:D273	R:R:I182	8.4	No	No	0	4	3
173	R:R:H184	R:R:L258	7.71	No	No	0	3	3
174	R:R:Q187	R:R:T185	5.67	No	No	0	2	2
175	R:R:E190	R:R:Q187	5.1	No	No	0	4	2
176	R:R:M192	R:R:W188	6.98	No	No	0	5	5
177	R:R:E190	R:R:R251	13.96	No	Yes	1	4	5
178	R:R:E190	R:R:F255	11.66	No	Yes	1	4	5
179	R:R:F193	R:R:R251	6.41	Yes	Yes	1	6	5
180	R:R:I252	R:R:L194	4.28	No	No	0	6	4
181	R:R:F197	R:R:F198	6.43	Yes	No	0	8	5
182	R:R:F197	R:R:L201	6.09	Yes	No	0	8	7
183	R:R:F197	R:R:F240	4.29	Yes	Yes	0	8	9
184	R:R:F197	R:R:L245	6.09	Yes	No	0	8	6
185	R:R:F197	R:R:V248	10.49	Yes	No	0	8	8
186	R:R:I203	R:R:L199	4.28	No	No	0	7	4
187	R:R:F240	R:R:I204	5.02	Yes	No	0	9	8
188	R:R:F206	R:R:R210	9.62	No	No	2	4	4
189	R:R:I212	R:R:R216	5.01	No	No	0	5	4
190	R:R:I212	R:R:I230	4.42	No	No	0	5	6
191	R:R:Q217	R:R:W213	8.76	No	No	0	5	3
192	R:R:I230	R:R:L215	4.28	No	No	0	6	8
193	R:R:D221	R:R:R216	7.15	No	No	0	3	4
194	R:R:H223	R:R:K225	11.79	No	No	0	4	5
195	R:R:I230	R:R:K227	5.82	No	No	0	6	4
196	R:R:F232	R:R:R228	5.34	No	No	0	7	7
197	R:R:P299	R:R:R228	4.32	No	No	0	5	7
198	R:R:F232	R:R:S297	7.93	No	No	0	7	6
199	R:R:V236	R:R:Y294	11.36	No	Yes	0	8	9
200	R:R:F240	R:R:F244	7.5	Yes	Yes	0	9	8
201	R:R:C243	R:R:M285	6.48	No	No	0	8	5
202	R:R:C243	R:R:N286	6.3	No	No	0	8	9
203	R:R:F244	R:R:T283	5.19	Yes	Yes	0	8	8
204	R:R:F244	R:R:N286	13.29	Yes	No	0	8	9
205	R:R:L245	R:R:V249	4.47	No	No	0	6	6
206	R:R:F282	R:R:P246	7.22	Yes	No	0	7	9
207	R:R:I254	R:R:R251	11.27	No	Yes	0	4	5
208	R:R:F255	R:R:R251	5.34	Yes	Yes	1	5	5
209	R:R:F276	R:R:R251	13.9	Yes	Yes	1	4	5
210	R:R:T260	R:R:W256	4.85	No	No	0	1	4
211	R:R:Q264	R:R:T263	5.67	No	No	0	3	3
212	R:R:N265	R:R:V268	4.43	No	No	0	5	1
213	R:R:E267	R:R:R270	4.65	No	No	0	2	1
214	R:R:V268	R:R:Y269	5.05	No	No	0	1	2
215	R:R:L274	R:R:S271	6.01	Yes	No	0	1	3
216	R:R:D273	R:R:F277	8.36	No	No	0	4	5
217	R:R:I278	R:R:L274	4.28	No	Yes	0	6	1
218	R:R:F276	R:R:F277	11.79	Yes	No	0	4	5
219	R:R:F282	R:R:T279	5.19	Yes	No	0	7	7
220	R:R:L280	R:R:T283	4.42	No	Yes	0	5	8
221	R:R:F282	R:R:M285	6.22	Yes	No	0	7	5
222	R:R:T283	R:R:Y284	6.24	Yes	Yes	0	8	7
223	R:R:D290	R:R:N286	8.08	Yes	No	0	9	9
224	R:R:D290	R:R:Y294	8.05	Yes	Yes	6	9	9
225	R:R:F301	R:R:Y295	5.16	Yes	Yes	0	9	7
226	R:R:F296	R:R:F301	4.29	No	Yes	0	8	9
227	R:R:P299	R:R:S298	5.34	No	No	0	5	8
228	R:R:S298	R:R:S300	4.89	No	No	0	8	5
229	R:R:L215	R:R:M220	4.24	No	No	0	8	3
230	R:R:L289	R:R:M288	4.24	No	No	0	7	8
231	R:R:C19	R:R:F21	4.19	No	No	0	4	2
232	R:R:A174	R:R:R22	4.15	No	No	0	2	3
233	R:R:L34	R:R:L80	4.15	No	No	0	8	8
234	R:R:L201	R:R:L205	4.15	No	No	0	7	4
235	R:R:G44	R:R:P291	4.06	No	No	0	7	9
236	R:R:G96	R:R:P99	4.06	No	No	0	7	5
237	R:R:A48	R:R:Y295	4	No	Yes	0	9	7
238	R:R:F193	R:R:S247	3.96	Yes	No	0	6	6
239	R:R:F282	R:R:S281	3.96	Yes	No	0	7	6
240	R:R:F276	R:R:V250	3.93	Yes	No	0	4	5
241	R:R:R90	R:R:V27	3.92	No	No	0	4	3
242	R:R:R253	R:R:V250	3.92	No	No	0	5	5
243	R:R:E196	R:R:Q112	3.82	No	No	0	5	7
244	R:R:V293	R:R:Y294	3.79	No	Yes	0	8	9
245	R:R:F65	R:R:I147	3.77	No	No	0	7	5
246	R:R:F25	R:R:K28	3.72	No	No	0	6	3
247	R:R:F40	R:R:L36	3.65	No	No	0	6	4
248	R:R:F255	R:R:L194	3.65	Yes	No	0	5	4
249	R:R:F255	R:R:L258	3.65	Yes	No	0	5	3
250	R:R:G113	R:R:T155	3.64	No	No	0	7	7
251	R:R:D273	R:R:F21	3.58	No	No	0	4	2
252	R:R:D92	R:R:R22	3.57	No	No	0	4	3
253	R:R:D92	R:R:R89	3.57	No	No	0	4	4
254	R:R:I26	R:R:W91	3.52	No	Yes	0	5	4
255	R:R:L257	R:R:Y269	3.52	No	No	0	3	2
256	R:R:G35	R:R:M84	3.49	No	No	0	5	7
257	R:R:C18	R:R:S181	3.44	No	No	0	9	4
258	R:R:A144	R:R:S61	3.42	No	No	0	7	6
259	R:R:C207	R:R:V123	3.42	No	No	0	8	6
260	R:R:C79	R:R:M106	3.24	No	Yes	0	6	5
261	R:R:S281	R:R:V33	3.23	No	No	0	6	5
262	R:R:S214	R:R:V129	3.23	No	No	0	5	8
263	R:R:S214	R:R:V130	3.23	No	Yes	0	5	8
264	R:R:V235	R:R:V293	3.21	No	No	0	5	8
265	R:R:S261	R:R:T260	3.2	No	No	0	3	1
266	R:R:G262	R:R:H184	3.18	No	No	0	4	3
267	R:R:I64	R:R:S148	3.1	No	No	0	7	8
268	R:R:I233	R:R:S208	3.1	No	No	0	7	8
269	R:R:K28	R:R:V29	3.04	No	No	0	3	5
270	R:R:I156	R:R:T159	3.04	No	Yes	0	4	7
271	R:R:L151	R:R:V120	2.98	No	No	0	7	7
272	R:R:L215	R:R:V129	2.98	No	No	0	8	8
273	R:R:L289	R:R:V239	2.98	No	No	0	7	7
274	R:R:L245	R:R:V241	2.98	No	No	0	6	5
275	R:R:D73	R:R:S114	2.94	Yes	No	0	9	9
276	R:R:I238	R:R:I242	2.94	No	No	0	5	5
277	R:R:I212	R:R:M234	2.92	No	No	0	5	4
278	R:R:I226	R:R:M220	2.92	No	No	0	6	3
279	R:R:K15	R:R:K16	2.87	No	No	0	3	4
280	R:R:I26	R:R:L274	2.85	No	Yes	0	5	1
281	R:R:I154	R:R:L150	2.85	No	No	0	5	4
282	R:R:L289	R:R:M285	2.83	No	No	0	7	5
283	R:R:C266	R:R:F10	2.79	No	No	0	7	7
284	R:R:P31	R:R:Y87	2.78	No	Yes	0	6	6
285	R:R:A191	R:R:F186	2.77	No	No	0	3	4
286	R:R:L195	R:R:L199	2.77	No	No	0	4	4
287	R:R:H223	R:R:I226	2.65	No	No	0	4	6
288	R:R:E267	R:R:N265	2.63	No	No	0	2	5
289	R:R:R253	R:R:V272	2.62	No	No	0	5	4
290	R:R:A72	R:R:W152	2.59	No	No	0	8	9
291	R:R:A191	R:R:W188	2.59	No	No	0	3	5
292	R:R:G172	R:R:G173	2.11	No	No	0	3	4
293	R:R:G153	R:R:I156	1.76	No	No	0	4	4
294	R:R:G44	R:R:L43	1.71	No	No	0	7	4
295	R:R:G202	R:R:L201	1.71	No	No	0	3	7
296	R:R:A237	R:R:S208	1.71	No	No	0	7	8
297	R:R:C19	R:R:T263	1.69	No	No	0	4	3
298	R:R:A108	R:R:T159	1.68	No	Yes	0	4	7
299	R:R:K225	R:R:P299	1.67	No	No	0	5	5
300	R:R:A122	R:R:I204	1.62	No	No	0	9	8
301	R:R:V292	R:R:V293	1.6	No	No	0	6	8
302	R:R:I156	R:R:V160	1.54	No	No	0	4	4
303	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
304	R:R:H133	R:R:P132	1.53	No	No	0	6	8
305	R:R:I139	R:R:T143	1.52	No	No	0	7	3
306	R:R:I147	R:R:T143	1.52	No	No	0	5	3
307	R:R:N141	R:R:S61	1.49	No	No	0	2	6
308	R:R:I116	R:R:I154	1.47	No	No	0	5	5
309	R:R:A135	R:R:H134	1.46	No	Yes	0	5	4
310	R:R:A224	R:R:H223	1.46	No	No	0	3	4
311	R:R:K138	R:R:N137	1.4	No	No	0	4	4
312	R:R:H259	R:R:T260	1.37	No	No	0	1	1
313	R:R:F232	R:R:T231	1.3	No	No	0	7	6
314	R:R:H134	R:R:N137	1.28	Yes	No	0	4	4
315	R:R:F40	R:R:I39	1.26	No	No	0	6	5
316	R:R:M220	R:R:R218	1.24	No	No	0	3	5
317	R:R:Q217	R:R:R218	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.64714	7	1	0
2	R:R:R63	6.0325	4	0	7
3	R:R:F67	7.8425	4	5	6
4	R:R:N68	8.7825	4	5	9
5	R:R:D73	6.3	5	6	9
6	R:R:Y87	9.836	5	0	6
7	R:R:W91	7.22667	6	4	4
8	R:R:W93	9.316	5	3	9
9	R:R:F95	9.746	5	3	7
10	R:R:R101	11.63	4	0	6
11	R:R:F105	9.6025	4	7	6
12	R:R:M106	5.2	4	7	5
13	R:R:M109	6.205	4	7	5
14	R:R:R111	6.928	5	1	8
15	R:R:Y126	9.06333	6	2	7
16	R:R:F127	7.665	4	2	5
17	R:R:V130	7.345	4	2	8
18	R:R:H131	5.7775	4	2	7
19	R:R:H134	5.7625	4	2	4
20	R:R:T159	3.9825	4	7	7
21	R:R:L176	5.824	5	4	4
22	R:R:F180	9.695	6	1	3
23	R:R:H189	9.78	4	1	5
24	R:R:F193	6.61	4	1	6
25	R:R:F197	6.678	5	0	8
26	R:R:F240	6.03	4	0	9
27	R:R:F244	9.0075	4	0	8
28	R:R:R251	9.72667	6	1	5
29	R:R:F255	6.075	4	1	5
30	R:R:L274	4.8075	4	0	1
31	R:R:F276	9.0125	4	1	4
32	R:R:F282	5.6475	4	0	7
33	R:R:T283	6.2275	4	0	8
34	R:R:Y284	6.33	4	0	7
35	R:R:D290	8.725	4	6	9
36	R:R:Y294	6.84833	6	6	9
37	R:R:Y295	4.7975	4	0	7
38	R:R:F301	8.296	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F180	R:R:F276	17.3264	6.43	Yes	Yes	1	3	4
2	R:R:F276	R:R:F277	17.3906	11.79	Yes	No	0	4	5
3	L:L:?1	R:R:L83	61.2973	5.13	Yes	No	0	0	6
4	R:R:L83	R:R:Y87	59.4782	15.24	No	Yes	0	6	6
5	R:R:W91	R:R:Y87	48.6197	7.72	Yes	Yes	0	4	6
6	R:R:L176	R:R:W91	17.7264	4.56	Yes	Yes	4	4	4
7	R:R:I169	R:R:L176	10.9261	5.71	No	Yes	0	1	4
8	R:R:N86	R:R:W91	32.8313	5.65	No	Yes	0	5	4
9	R:R:N86	R:R:W93	31.5059	7.91	No	Yes	0	5	9
10	R:R:F95	R:R:W93	25.4902	16.04	Yes	Yes	3	7	9
11	R:R:D85	R:R:F95	13.0328	5.97	No	Yes	3	4	7
12	R:R:D85	R:R:R89	11.4095	10.72	No	No	3	4	4
13	R:R:D92	R:R:R89	19.5648	3.57	No	No	0	4	4
14	R:R:D92	R:R:R22	16.3081	3.57	No	No	0	4	3
15	R:R:F95	R:R:K94	13.0328	14.89	Yes	No	3	7	3
16	R:R:K94	R:R:R89	11.4095	9.9	No	No	3	3	4
17	R:R:I26	R:R:W91	11.2509	3.52	No	Yes	0	5	4
18	L:L:?1	R:R:Y284	34.2926	7.61	Yes	Yes	0	0	7
19	L:L:?1	R:R:R111	17.2514	10.14	Yes	Yes	1	0	8
20	R:R:R111	R:R:T283	44.5201	9.06	Yes	Yes	0	8	8
21	R:R:F244	R:R:T283	78.6659	5.19	Yes	Yes	0	8	8
22	R:R:F244	R:R:N286	40.3825	13.29	Yes	No	0	8	9
23	L:L:?1	R:R:L280	16.5418	11.55	Yes	No	0	0	5
24	R:R:L280	R:R:T283	16.7131	4.42	No	Yes	0	5	8
25	R:R:T283	R:R:Y284	18.1069	6.24	Yes	Yes	0	8	7
26	R:R:L76	R:R:Y284	19.3826	5.86	No	Yes	0	7	7
27	R:R:L76	R:R:S287	28.277	4.5	No	No	0	7	8
28	R:R:D73	R:R:S287	28.4052	4.42	Yes	No	0	9	8
29	R:R:F240	R:R:F244	41.1858	7.5	Yes	Yes	0	9	8
30	R:R:F240	R:R:L118	38.0007	7.31	Yes	No	0	9	9
31	R:R:L118	R:R:Y294	37.8649	7.03	No	Yes	0	9	9
32	R:R:R125	R:R:Y294	100	6.17	No	Yes	0	9	9
33	R:R:R125	R:R:V121	97.4309	6.54	No	No	0	9	9
34	R:R:L66	R:R:V121	96.7871	4.47	No	No	0	8	9
35	R:R:L66	R:R:R63	68.3406	4.86	No	Yes	0	8	7
36	R:R:F301	R:R:R63	27.2519	4.28	Yes	Yes	0	9	7
37	R:R:D290	R:R:N286	38.0623	8.08	Yes	No	0	9	9
38	R:R:D290	R:R:Y294	51.5963	8.05	Yes	Yes	6	9	9
39	R:R:D290	R:R:D73	15.5285	11.98	Yes	Yes	6	9	9
40	R:R:D73	R:R:L69	14.7388	5.43	Yes	No	6	9	9
41	R:R:L69	R:R:Y294	14.7185	4.69	No	Yes	6	9	9
42	R:R:L66	R:R:Y295	28.0779	4.69	No	Yes	0	8	7
43	R:R:F301	R:R:Y295	25.8125	5.16	Yes	Yes	0	9	7
44	R:R:F301	R:R:F52	40.2729	13.93	Yes	No	0	9	7
45	R:R:F52	R:R:F67	37.2726	9.65	No	Yes	5	7	6
46	R:R:F67	R:R:N68	34.0885	4.83	Yes	Yes	5	6	9
47	R:R:N68	R:R:S148	13.0294	8.94	Yes	No	0	9	8
48	R:R:I64	R:R:S148	11.4036	3.1	No	No	0	7	8
49	R:R:R63	R:R:S300	42.9204	5.27	Yes	No	0	7	5
50	R:R:S298	R:R:S300	42.2201	4.89	No	No	0	8	5
51	R:R:P299	R:R:S298	41.4456	5.34	No	No	0	5	8
52	R:R:K225	R:R:P299	37.6152	1.67	No	No	0	5	5
53	R:R:H223	R:R:K225	36.9039	11.79	No	No	0	4	5
54	R:R:H223	R:R:I226	35.3296	2.65	No	No	0	4	6
55	R:R:I226	R:R:M220	34.5398	2.92	No	No	0	6	3
56	R:R:L215	R:R:M220	31.3641	4.24	No	No	0	8	3
57	R:R:L215	R:R:V129	25.8024	2.98	No	No	0	8	8
58	R:R:S214	R:R:V129	24.1875	3.23	No	No	0	5	8
59	R:R:S214	R:R:V130	23.3725	3.23	No	Yes	0	5	8
60	R:R:V130	R:R:Y126	10.8223	12.62	Yes	Yes	2	8	7
61	R:R:F127	R:R:H134	11.7841	11.31	Yes	Yes	2	5	4
62	R:R:H131	R:R:V130	10.0613	8.3	Yes	Yes	2	7	8
63	R:R:F117	R:R:N68	16.2676	15.71	No	Yes	5	8	9
64	R:R:F117	R:R:L151	14.662	4.87	No	No	0	8	7
65	R:R:L76	R:R:N110	14.6156	5.49	No	No	0	7	9
66	R:R:M106	R:R:N110	13.9406	7.01	Yes	No	0	5	9
67	R:R:F277	R:R:W91	14.7	12.03	No	Yes	0	5	4
68	R:R:F180	R:R:R111	22.5878	5.34	Yes	Yes	1	3	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	5.13	1	Yes	No	0	6	0	1
L:L:?1	R:R:L107	8.98	1	Yes	No	0	6	0	1
L:L:?1	R:R:R111	10.14	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S179	6.96	1	Yes	No	0	4	0	1
L:L:?1	R:R:F180	10.16	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:L280	11.55	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	7.61	1	Yes	Yes	0	7	0	1
R:R:E37	R:R:Y284	5.61	0	No	Yes	7	7	2	1
R:R:L76	R:R:Y284	5.86	0	No	Yes	7	7	2	1
R:R:L83	R:R:Y87	15.24	0	No	Yes	6	6	1	2
R:R:L83	R:R:M103	5.65	0	No	No	6	5	1	2
R:R:L107	R:R:M103	5.65	0	No	No	6	5	1	2
R:R:L104	R:R:S179	6.01	0	No	No	5	4	2	1
R:R:F180	R:R:R111	5.34	1	Yes	Yes	3	8	1	1
R:R:F193	R:R:R111	4.28	1	Yes	Yes	6	8	2	1
R:R:E196	R:R:R111	5.82	0	No	Yes	5	8	2	1
R:R:R111	R:R:T283	9.06	1	Yes	Yes	8	8	1	2
R:R:H189	R:R:S179	8.37	1	Yes	No	5	4	2	1
R:R:F180	R:R:H189	16.97	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F193	11.79	1	Yes	Yes	3	6	1	2
R:R:F180	R:R:R251	7.48	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	6.43	1	Yes	Yes	3	4	1	2
R:R:F193	R:R:R251	6.41	1	Yes	Yes	6	5	2	2
R:R:F276	R:R:R251	13.9	1	Yes	Yes	4	5	2	2
R:R:L280	R:R:T283	4.42	0	No	Yes	5	8	1	2
R:R:T283	R:R:Y284	6.24	0	Yes	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IJA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.28
Number of Linked Nodes	284
Number of Links	317
Number of Hubs	38
Number of Links mediated by Hubs	137
Number of Communities	8
Number of Nodes involved in Communities	49
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	157312
Length Of Smallest Path	3
Average Path Length	20.7127
Length of Longest Path	40
Minimum Path Strength	1.205
Average Path Strength	6.90806
Maximum Path Strength	20.675
Minimum Path Correlation	0.7
Average Path Correlation	0.91984
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	32.6531
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.3842
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • cellular process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • protein localization • positive regulation of cell communication • regulation of localization • establishment of protein localization • system process • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • cellular macromolecule localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • cellular localization • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • regulation of cellular localization • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • cellular anatomical structure • cell junction • cell periphery • plasma membrane • membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NIO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NIO
Name	Niacin
Synonyms	3-carboxypyridine
Identifier
Formula	C6 H5 N O2
Molecular Weight	123.109
SMILES
PubChem	938
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	14
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8IJA_nogp_Chain_R D H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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