psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	10.03	Yes	No	1	0	6
2	L:L:?1	R:R:Y87	3.78	Yes	Yes	1	0	6
3	L:L:?1	R:R:W91	5.5	Yes	Yes	1	0	4
4	L:L:?1	R:R:L104	8.92	Yes	No	1	0	5
5	L:L:?1	R:R:L107	11.15	Yes	Yes	1	0	6
6	L:L:?1	R:R:A108	3.81	Yes	No	0	0	4
7	L:L:?1	R:R:R111	8.8	Yes	No	1	0	8
8	L:L:?1	R:R:S179	9.67	Yes	Yes	1	0	4
9	L:L:?1	R:R:F180	15.69	Yes	Yes	1	0	3
10	L:L:?1	R:R:H189	7.25	Yes	Yes	1	0	5
11	L:L:?1	R:R:L280	14.49	Yes	No	0	0	5
12	L:L:?1	R:R:Y284	13.22	Yes	Yes	1	0	7
13	R:R:H5	R:R:M1	3.94	No	No	0	5	6
14	R:R:L6	R:R:R3	8.5	No	No	0	6	6
15	R:R:Q7	R:R:R3	9.35	No	No	0	7	6
16	R:R:D8	R:R:H5	8.82	No	No	0	6	5
17	R:R:H5	R:R:H9	8.36	No	No	0	5	6
18	R:R:E267	R:R:L6	5.3	No	No	0	2	6
19	R:R:F21	R:R:H9	5.66	Yes	No	0	2	6
20	R:R:E267	R:R:H9	7.39	No	No	0	2	6
21	R:R:F10	R:R:N17	6.04	No	No	0	7	5
22	R:R:I13	R:R:L11	5.71	Yes	No	0	3	8
23	R:R:L11	R:R:N171	13.73	No	No	0	8	1
24	R:R:D14	R:R:I13	4.2	No	Yes	0	5	3
25	R:R:C18	R:R:I13	6.55	No	Yes	0	9	3
26	R:R:I13	R:R:I169	10.3	Yes	No	0	3	1
27	R:R:D14	R:R:K165	11.06	No	No	0	5	4
28	R:R:K15	R:R:T185	4.5	No	No	0	3	2
29	R:R:K16	R:R:N17	12.59	No	No	6	4	5
30	R:R:H184	R:R:K16	6.55	No	No	6	3	4
31	R:R:H184	R:R:N17	17.86	No	No	6	3	5
32	R:R:C19	R:R:F21	5.59	No	Yes	0	4	2
33	R:R:C19	R:R:C266	5.46	No	No	0	4	7
34	R:R:V20	R:R:W91	3.68	No	Yes	0	2	4
35	R:R:L176	R:R:V20	4.47	No	No	0	4	2
36	R:R:F21	R:R:Y269	4.13	Yes	Yes	0	2	2
37	R:R:F21	R:R:R270	5.34	Yes	No	0	2	1
38	R:R:A174	R:R:R22	4.15	No	No	0	2	3
39	R:R:D24	R:R:I26	7	No	No	0	4	5
40	R:R:F25	R:R:K28	8.69	No	No	0	6	3
41	R:R:F25	R:R:L274	3.65	No	No	0	6	1
42	R:R:I26	R:R:W91	3.52	No	Yes	0	5	4
43	R:R:R90	R:R:V27	17	No	No	0	4	3
44	R:R:L30	R:R:Y87	10.55	No	Yes	0	5	6
45	R:R:P31	R:R:P32	7.79	No	No	0	6	5
46	R:R:P31	R:R:V88	3.53	No	No	0	6	3
47	R:R:E37	R:R:V33	7.13	Yes	No	0	7	5
48	R:R:L34	R:R:L80	4.15	No	No	0	8	8
49	R:R:L34	R:R:M84	4.24	No	No	0	8	7
50	R:R:L34	R:R:Y87	3.52	No	Yes	0	8	6
51	R:R:G35	R:R:M84	3.49	No	No	0	5	7
52	R:R:E37	R:R:L36	3.98	Yes	No	0	7	4
53	R:R:F40	R:R:L36	3.65	No	No	0	6	4
54	R:R:E37	R:R:Y284	5.61	Yes	Yes	0	7	7
55	R:R:E37	R:R:M285	6.77	Yes	No	0	7	5
56	R:R:F38	R:R:L42	3.65	No	No	0	7	7
57	R:R:F38	R:R:P81	7.22	No	No	0	7	8
58	R:R:F40	R:R:M288	6.22	No	No	0	6	8
59	R:R:G41	R:R:I77	3.53	No	No	0	8	6
60	R:R:G44	R:R:L47	5.13	No	No	0	7	6
61	R:R:D73	R:R:N45	5.39	Yes	No	0	9	9
62	R:R:F74	R:R:N45	7.25	No	No	0	7	9
63	R:R:A48	R:R:F52	4.16	No	Yes	0	9	7
64	R:R:F74	R:R:L49	4.87	No	No	0	7	7
65	R:R:F301	R:R:I51	5.02	Yes	No	0	9	7
66	R:R:F304	R:R:I51	5.02	No	No	0	4	7
67	R:R:F52	R:R:F67	6.43	Yes	No	0	7	6
68	R:R:A70	R:R:F52	4.16	No	Yes	3	8	7
69	R:R:F52	R:R:Y295	11.35	Yes	Yes	3	7	7
70	R:R:F54	R:R:H55	5.66	No	No	0	4	5
71	R:R:F304	R:R:H55	20.36	No	No	0	4	5
72	R:R:I64	R:R:W59	11.74	Yes	No	0	7	6
73	R:R:F65	R:R:S61	5.28	No	No	0	7	6
74	R:R:A144	R:R:S61	3.42	No	No	0	7	6
75	R:R:R63	R:R:S62	3.95	No	No	0	7	8
76	R:R:F65	R:R:V120	7.87	No	No	0	7	7
77	R:R:L66	R:R:V121	4.47	No	No	0	8	9
78	R:R:L66	R:R:Y294	3.52	No	Yes	0	8	9
79	R:R:L66	R:R:Y295	8.21	No	Yes	0	8	7
80	R:R:F67	R:R:V71	7.87	No	No	0	6	6
81	R:R:F117	R:R:N68	12.08	No	No	2	8	9
82	R:R:N68	R:R:S148	8.94	No	No	0	9	8
83	R:R:N68	R:R:W152	5.65	No	Yes	2	9	9
84	R:R:D73	R:R:L69	8.14	Yes	No	3	9	9
85	R:R:L69	R:R:S114	4.5	No	No	3	9	9
86	R:R:L69	R:R:Y295	3.52	No	Yes	3	9	7
87	R:R:A70	R:R:Y295	4	No	Yes	3	8	7
88	R:R:D73	R:R:S114	5.89	Yes	No	3	9	9
89	R:R:D73	R:R:S287	4.42	Yes	No	0	9	8
90	R:R:D290	R:R:D73	7.98	No	Yes	0	9	9
91	R:R:F74	R:R:I78	11.3	No	No	0	7	6
92	R:R:L75	R:R:M106	5.65	No	No	2	6	5
93	R:R:L75	R:R:N110	12.36	No	No	2	6	9
94	R:R:L107	R:R:L76	4.15	Yes	No	1	6	7
95	R:R:L76	R:R:Y284	5.86	No	Yes	1	7	7
96	R:R:L76	R:R:S287	6.01	No	No	0	7	8
97	R:R:C79	R:R:M106	4.86	No	No	0	6	5
98	R:R:L80	R:R:Y284	8.21	No	Yes	0	8	7
99	R:R:L83	R:R:Y87	4.69	No	Yes	1	6	6
100	R:R:L83	R:R:Y284	3.52	No	Yes	1	6	7
101	R:R:N86	R:R:Y87	8.14	No	Yes	1	5	6
102	R:R:N86	R:R:W91	10.17	No	Yes	1	5	4
103	R:R:N86	R:R:W93	4.52	No	Yes	1	5	9
104	R:R:W91	R:R:Y87	7.72	Yes	Yes	1	4	6
105	R:R:F277	R:R:Y87	5.16	No	Yes	1	5	6
106	R:R:R89	R:R:V88	3.92	No	No	0	4	3
107	R:R:F277	R:R:W91	8.02	No	Yes	1	5	4
108	R:R:F95	R:R:W93	21.05	No	Yes	0	7	9
109	R:R:C100	R:R:W93	7.84	No	Yes	1	9	9
110	R:R:M103	R:R:W93	5.82	Yes	Yes	0	5	9
111	R:R:N175	R:R:W93	4.52	Yes	Yes	0	4	9
112	R:R:C177	R:R:W93	16.98	No	Yes	1	9	9
113	R:R:G96	R:R:P99	4.06	No	No	0	7	5
114	R:R:D97	R:R:I98	5.6	Yes	No	0	3	2
115	R:R:D97	R:R:R101	14.29	Yes	No	0	3	6
116	R:R:D97	R:R:P168	9.66	Yes	No	0	3	4
117	R:R:I98	R:R:P99	3.39	No	No	0	2	5
118	R:R:C100	R:R:C177	5.46	No	No	1	9	9
119	R:R:L163	R:R:R101	3.64	No	No	0	5	6
120	R:R:L104	R:R:M103	8.48	No	Yes	0	5	5
121	R:R:L107	R:R:M103	5.65	Yes	Yes	0	6	5
122	R:R:L104	R:R:S179	4.5	No	Yes	1	5	4
123	R:R:F105	R:R:M109	6.22	Yes	Yes	2	6	5
124	R:R:F105	R:R:I156	3.77	Yes	No	2	6	4
125	R:R:F105	R:R:T159	6.49	Yes	No	2	6	7
126	R:R:F105	R:R:L163	8.53	Yes	No	0	6	5
127	R:R:M106	R:R:N110	5.61	No	No	2	5	9
128	R:R:L107	R:R:Y284	3.52	Yes	Yes	1	6	7
129	R:R:M109	R:R:N110	5.61	Yes	No	2	5	9
130	R:R:M109	R:R:W152	4.65	Yes	Yes	2	5	9
131	R:R:M109	R:R:T155	4.52	Yes	No	0	5	7
132	R:R:I156	R:R:M109	4.37	No	Yes	2	4	5
133	R:R:M109	R:R:T159	4.52	Yes	No	2	5	7
134	R:R:F193	R:R:R111	10.69	No	No	1	6	8
135	R:R:E196	R:R:R111	8.14	No	No	1	5	8
136	R:R:Q112	R:R:T155	4.25	No	No	0	7	7
137	R:R:L158	R:R:Q112	5.32	No	No	0	5	7
138	R:R:M192	R:R:Q112	9.52	No	No	0	5	7
139	R:R:G113	R:R:T155	5.46	No	No	0	7	7
140	R:R:E196	R:R:I115	6.83	No	No	0	5	8
141	R:R:I115	R:R:P200	3.39	No	No	0	8	9
142	R:R:F244	R:R:I115	8.79	Yes	No	0	8	8
143	R:R:I116	R:R:L151	5.71	No	No	0	5	7
144	R:R:F117	R:R:L151	4.87	No	No	0	8	7
145	R:R:F117	R:R:W152	17.04	No	Yes	2	8	9
146	R:R:L118	R:R:Y294	3.52	No	Yes	0	9	9
147	R:R:P200	R:R:T119	6.99	No	No	0	9	7
148	R:R:R125	R:R:V121	5.23	No	No	0	9	9
149	R:R:D124	R:R:R128	13.1	No	No	0	8	8
150	R:R:R125	R:R:Y294	5.14	No	Yes	0	9	9
151	R:R:V130	R:R:Y126	11.36	Yes	Yes	4	8	7
152	R:R:F206	R:R:Y126	6.19	No	Yes	0	4	7
153	R:R:C207	R:R:Y126	6.72	No	Yes	0	8	7
154	R:R:R210	R:R:Y126	9.26	No	Yes	4	4	7
155	R:R:F127	R:R:H134	4.53	Yes	No	4	5	4
156	R:R:F127	R:R:K138	8.69	Yes	No	4	5	4
157	R:R:I211	R:R:V129	9.22	No	No	0	8	8
158	R:R:L215	R:R:V129	4.47	No	No	0	8	8
159	R:R:H131	R:R:V130	9.69	No	Yes	0	7	8
160	R:R:R210	R:R:V130	5.23	No	Yes	4	4	8
161	R:R:S214	R:R:V130	4.85	No	Yes	0	5	8
162	R:R:H134	R:R:N137	7.65	No	No	0	4	4
163	R:R:H134	R:R:K138	7.86	No	No	4	4	4
164	R:R:S140	R:R:T143	6.4	No	No	0	6	3
165	R:R:I146	R:R:R142	5.01	No	No	0	3	4
166	R:R:I154	R:R:L150	5.71	No	No	0	5	4
167	R:R:G157	R:R:I156	3.53	No	No	0	5	4
168	R:R:G157	R:R:V160	3.68	No	No	0	5	4
169	R:R:L158	R:R:W188	4.56	No	No	0	5	5
170	R:R:H161	R:R:L162	9	No	No	0	7	4
171	R:R:H161	R:R:W188	4.23	No	No	0	7	5
172	R:R:H161	R:R:H189	3.58	No	Yes	0	7	5
173	R:R:N175	R:R:P168	6.52	Yes	No	0	4	4
174	R:R:L176	R:R:S178	6.01	No	No	0	4	4
175	R:R:F180	R:R:S179	5.28	Yes	Yes	1	3	4
176	R:R:H189	R:R:S179	5.58	Yes	Yes	1	5	4
177	R:R:F180	R:R:H189	7.92	Yes	Yes	1	3	5
178	R:R:F180	R:R:R251	6.41	Yes	Yes	1	3	5
179	R:R:F180	R:R:F276	11.79	Yes	Yes	1	3	4
180	R:R:I182	R:R:Y269	9.67	No	Yes	7	3	2
181	R:R:D273	R:R:I182	8.4	No	No	7	4	3
182	R:R:C183	R:R:T185	5.07	No	No	0	1	2
183	R:R:H184	R:R:T263	9.58	No	No	0	3	3
184	R:R:F186	R:R:F255	7.5	No	No	0	4	5
185	R:R:E190	R:R:Q187	6.37	Yes	No	0	4	2
186	R:R:M192	R:R:W188	12.8	No	No	0	5	5
187	R:R:E190	R:R:H189	3.69	Yes	Yes	1	4	5
188	R:R:E190	R:R:R251	5.82	Yes	Yes	1	4	5
189	R:R:E190	R:R:F255	3.5	Yes	No	1	4	5
190	R:R:E196	R:R:F193	4.66	No	No	1	5	6
191	R:R:F198	R:R:L194	4.87	No	No	5	5	4
192	R:R:L194	R:R:V248	4.47	No	Yes	5	4	8
193	R:R:F197	R:R:F198	4.29	Yes	No	5	8	5
194	R:R:F197	R:R:L201	6.09	Yes	Yes	5	8	7
195	R:R:F197	R:R:F240	5.36	Yes	Yes	5	8	9
196	R:R:F197	R:R:L245	3.65	Yes	No	0	8	6
197	R:R:F197	R:R:V248	11.8	Yes	Yes	5	8	8
198	R:R:F198	R:R:V248	3.93	No	Yes	5	5	8
199	R:R:G202	R:R:L201	3.42	No	Yes	0	3	7
200	R:R:L201	R:R:L205	5.54	Yes	No	0	7	4
201	R:R:F240	R:R:L201	6.09	Yes	Yes	5	9	7
202	R:R:F240	R:R:I204	7.54	Yes	No	0	9	8
203	R:R:I212	R:R:R216	10.02	No	No	9	5	4
204	R:R:I212	R:R:I230	7.36	No	No	9	5	6
205	R:R:Q217	R:R:W213	4.38	No	No	0	5	3
206	R:R:I230	R:R:L215	7.14	No	No	0	6	8
207	R:R:M220	R:R:R216	8.69	No	No	0	3	4
208	R:R:I230	R:R:R216	3.76	No	No	9	6	4
209	R:R:Q219	R:R:R218	9.35	No	No	0	3	5
210	R:R:Q219	R:R:R222	9.35	No	No	0	3	3
211	R:R:K227	R:R:M220	5.76	No	No	0	4	3
212	R:R:H223	R:R:K225	17.03	No	No	0	4	5
213	R:R:K227	R:R:T231	4.5	No	No	0	4	6
214	R:R:F232	R:R:S297	5.28	No	No	0	7	6
215	R:R:V236	R:R:Y294	10.09	No	Yes	0	8	9
216	R:R:N286	R:R:V239	4.43	Yes	No	0	9	7
217	R:R:F240	R:R:F244	7.5	Yes	Yes	0	9	8
218	R:R:C243	R:R:N286	9.45	No	Yes	0	8	9
219	R:R:F244	R:R:T283	7.78	Yes	No	0	8	8
220	R:R:F244	R:R:N286	4.83	Yes	Yes	0	8	9
221	R:R:P246	R:R:T279	3.5	No	Yes	0	9	7
222	R:R:S247	R:R:T279	7.99	No	Yes	0	6	7
223	R:R:F276	R:R:V250	6.55	Yes	No	1	4	5
224	R:R:T279	R:R:V250	6.35	Yes	No	1	7	5
225	R:R:I254	R:R:R251	5.01	No	Yes	0	4	5
226	R:R:F255	R:R:R251	4.28	No	Yes	1	5	5
227	R:R:F276	R:R:R251	16.03	Yes	Yes	1	4	5
228	R:R:I254	R:R:Y269	8.46	No	Yes	0	4	2
229	R:R:L257	R:R:W256	6.83	Yes	No	0	3	4
230	R:R:H259	R:R:L258	3.86	No	No	0	1	3
231	R:R:H259	R:R:T260	8.21	No	No	0	1	1
232	R:R:V272	R:R:Y269	15.14	No	Yes	0	4	2
233	R:R:D273	R:R:Y269	16.09	No	Yes	7	4	2
234	R:R:F276	R:R:T279	5.19	Yes	Yes	1	4	7
235	R:R:F276	R:R:L280	8.53	Yes	No	0	4	5
236	R:R:F282	R:R:S281	3.96	No	No	0	7	6
237	R:R:M285	R:R:M288	5.78	No	No	8	5	8
238	R:R:L289	R:R:M285	5.65	No	No	8	7	5
239	R:R:D290	R:R:N286	5.39	No	Yes	0	9	9
240	R:R:L289	R:R:M288	4.24	No	No	8	7	8
241	R:R:P291	R:R:Y295	4.17	No	Yes	0	9	7
242	R:R:F296	R:R:V292	7.87	No	No	0	8	6
243	R:R:V293	R:R:Y294	3.79	No	Yes	0	8	9
244	R:R:F301	R:R:Y295	6.19	Yes	Yes	0	9	7
245	R:R:F296	R:R:F301	6.43	No	Yes	0	8	9
246	R:R:F301	R:R:S298	3.96	Yes	No	0	9	8
247	R:R:F304	R:R:S300	3.96	No	No	0	4	5
248	R:R:M167	R:R:P168	3.35	No	No	0	3	4
249	R:R:G172	R:R:Q170	3.29	No	No	0	3	1
250	R:R:G173	R:R:Q170	3.29	No	No	0	4	1
251	R:R:L199	R:R:P200	3.28	No	No	0	4	9
252	R:R:A144	R:R:I64	3.25	No	Yes	0	7	7
253	R:R:S181	R:R:V20	3.23	No	No	0	4	2
254	R:R:S281	R:R:V33	3.23	No	No	0	6	5
255	R:R:S261	R:R:V268	3.23	No	No	0	3	1
256	R:R:I13	R:R:S181	3.1	Yes	No	0	3	4
257	R:R:I64	R:R:S148	3.1	Yes	No	0	7	8
258	R:R:I233	R:R:S208	3.1	No	No	0	7	8
259	R:R:I278	R:R:S281	3.1	No	No	0	6	6
260	R:R:F127	R:R:Y126	3.09	Yes	Yes	4	5	7
261	R:R:I278	R:R:V29	3.07	No	No	0	6	5
262	R:R:I252	R:R:V248	3.07	No	Yes	0	6	8
263	R:R:I203	R:R:T119	3.04	No	No	0	7	7
264	R:R:I147	R:R:T143	3.04	No	No	0	5	3
265	R:R:L201	R:R:V241	2.98	Yes	No	0	7	5
266	R:R:L245	R:R:V249	2.98	No	No	0	6	6
267	R:R:I77	R:R:I78	2.94	No	No	0	6	6
268	R:R:I238	R:R:I242	2.94	No	No	0	5	5
269	R:R:I212	R:R:M234	2.92	No	No	0	5	4
270	R:R:I26	R:R:L274	2.85	No	No	0	5	1
271	R:R:I77	R:R:L42	2.85	No	No	0	6	7
272	R:R:I98	R:R:L102	2.85	No	No	0	2	5
273	R:R:I147	R:R:L151	2.85	No	No	0	5	7
274	R:R:I154	R:R:L158	2.85	No	No	0	5	5
275	R:R:I226	R:R:L215	2.85	No	No	0	6	8
276	R:R:I64	R:R:N141	2.83	Yes	No	0	7	2
277	R:R:H55	R:R:S58	2.79	No	No	0	5	6
278	R:R:D97	R:R:K166	2.77	Yes	No	0	3	4
279	R:R:A135	R:R:R128	2.77	No	No	0	5	8
280	R:R:I226	R:R:Q219	2.74	No	No	0	6	3
281	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
282	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
283	R:R:I139	R:R:R128	2.51	No	No	0	7	8
284	R:R:F82	R:R:M103	2.49	No	Yes	0	6	5
285	R:R:F296	R:R:L47	2.44	No	No	0	8	6
286	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
287	R:R:D85	R:R:F95	2.39	No	No	0	4	7
288	R:R:D23	R:R:R22	2.38	No	No	0	4	3
289	R:R:L257	R:R:Y269	2.34	Yes	Yes	0	3	2
290	R:R:E12	R:R:F10	2.33	No	No	0	5	7
291	R:R:H259	R:R:W256	2.12	No	No	0	1	4
292	R:R:R63	R:R:W59	2	No	No	0	7	6
293	R:R:G262	R:R:T263	1.82	No	No	0	4	3
294	R:R:A122	R:R:C207	1.81	No	No	0	9	8
295	R:R:P299	R:R:S298	1.78	No	No	0	5	8
296	R:R:G44	R:R:L43	1.71	No	No	0	7	4
297	R:R:A237	R:R:S208	1.71	No	No	0	7	8
298	R:R:G262	R:R:L257	1.71	No	Yes	0	4	3
299	R:R:K225	R:R:P299	1.67	No	No	0	5	5
300	R:R:L30	R:R:P31	1.64	No	No	0	5	6
301	R:R:C207	R:R:I203	1.64	No	No	0	8	7
302	R:R:C243	R:R:I242	1.64	No	No	0	8	5
303	R:R:A237	R:R:I204	1.62	No	No	0	7	8
304	R:R:S271	R:R:V272	1.62	No	No	0	3	4
305	R:R:V235	R:R:V239	1.6	No	No	0	5	7
306	R:R:A174	R:R:D92	1.54	No	No	0	2	4
307	R:R:K60	R:R:S62	1.53	No	No	0	7	8
308	R:R:H131	R:R:P132	1.53	No	No	0	7	8
309	R:R:H133	R:R:P132	1.53	No	No	0	6	8
310	R:R:K28	R:R:V27	1.52	No	No	0	3	3
311	R:R:K164	R:R:V160	1.52	No	No	0	4	4
312	R:R:L257	R:R:S261	1.5	Yes	No	0	3	3
313	R:R:N265	R:R:V268	1.48	No	No	0	5	1
314	R:R:D124	R:R:S62	1.47	No	No	0	8	8
315	R:R:L308	R:R:T307	1.47	No	No	0	5	4
316	R:R:A224	R:R:H223	1.46	No	No	0	3	4
317	R:R:F301	R:R:P302	1.44	Yes	No	0	9	8
318	R:R:I51	R:R:L308	1.43	No	No	0	7	5
319	R:R:I139	R:R:L136	1.43	No	No	0	7	4
320	R:R:Q264	R:R:T263	1.42	No	No	0	3	3
321	R:R:G153	R:R:W152	1.41	No	Yes	0	4	9
322	R:R:L195	R:R:M192	1.41	No	No	0	4	5
323	R:R:C53	R:R:F54	1.4	No	No	0	4	4
324	R:R:D92	R:R:N175	1.35	No	Yes	0	4	4
325	R:R:R142	R:R:S140	1.32	No	No	0	4	6
326	R:R:N175	R:R:Q170	1.32	Yes	No	0	4	1
327	R:R:F305	R:R:S306	1.32	No	No	0	6	4
328	R:R:R253	R:R:V272	1.31	No	No	0	5	4
329	R:R:F232	R:R:T231	1.3	No	No	0	7	6
330	R:R:H4	R:R:L6	1.29	No	No	0	5	6
331	R:R:R228	R:R:T231	1.29	No	No	0	7	6
332	R:R:F38	R:R:I39	1.26	No	No	0	7	5
333	R:R:F40	R:R:I39	1.26	No	No	0	6	5
334	R:R:Q217	R:R:R218	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.35917	12	1	0
2	R:R:I13	5.972	5	0	3
3	R:R:F21	5.18	4	0	2
4	R:R:E37	5.8725	4	0	7
5	R:R:F52	6.525	4	3	7
6	R:R:I64	5.23	4	0	7
7	R:R:D73	6.364	5	3	9
8	R:R:Y87	6.22286	7	1	6
9	R:R:W91	6.435	6	1	4
10	R:R:W93	10.1217	6	1	9
11	R:R:D97	8.08	4	0	3
12	R:R:M103	5.61	4	0	5
13	R:R:F105	6.2525	4	2	6
14	R:R:L107	6.1175	4	1	6
15	R:R:M109	4.98167	6	2	5
16	R:R:Y126	6.50667	6	4	7
17	R:R:F127	4.7325	4	4	5
18	R:R:V130	7.7825	4	4	8
19	R:R:W152	6.268	5	2	9
20	R:R:N175	3.4275	4	0	4
21	R:R:S179	6.2575	4	1	4
22	R:R:F180	9.418	5	1	3
23	R:R:H189	5.604	5	1	5
24	R:R:E190	4.845	4	1	4
25	R:R:F197	6.238	5	5	8
26	R:R:L201	4.824	5	5	7
27	R:R:F240	6.6225	4	5	9
28	R:R:F244	7.225	4	0	8
29	R:R:V248	5.8175	4	5	8
30	R:R:R251	7.51	5	1	5
31	R:R:L257	3.095	4	0	3
32	R:R:Y269	9.305	6	7	2
33	R:R:F276	9.618	5	1	4
34	R:R:T279	5.7575	4	1	7
35	R:R:Y284	6.65667	6	1	7
36	R:R:N286	6.025	4	0	9
37	R:R:Y294	5.212	5	0	9
38	R:R:Y295	6.24	6	3	7
39	R:R:F301	4.608	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F180	48.832	15.69	Yes	Yes	1	0	3
2	R:R:F180	R:R:R251	58.5257	6.41	Yes	Yes	1	3	5
3	R:R:I254	R:R:R251	68.1109	5.01	No	Yes	0	4	5
4	R:R:I254	R:R:Y269	66.324	8.46	No	Yes	0	4	2
5	R:R:F21	R:R:Y269	25.598	4.13	Yes	Yes	0	2	2
6	R:R:F21	R:R:H9	17.9675	5.66	Yes	No	0	2	6
7	R:R:E267	R:R:H9	10.0504	7.39	No	No	0	2	6
8	R:R:L257	R:R:Y269	31.5534	2.34	Yes	Yes	0	3	2
9	R:R:G262	R:R:L257	15.9987	1.71	No	Yes	0	4	3
10	R:R:G262	R:R:T263	14.0229	1.82	No	No	0	4	3
11	R:R:H184	R:R:T263	10.0504	9.58	No	No	0	3	3
12	L:L:?1	R:R:W91	33.8754	5.5	Yes	Yes	1	0	4
13	R:R:V20	R:R:W91	14.6419	3.68	No	Yes	0	2	4
14	R:R:S181	R:R:V20	10.6798	3.23	No	No	0	4	2
15	L:L:?1	R:R:Y87	21.2617	3.78	Yes	Yes	1	0	6
16	R:R:N86	R:R:Y87	12.3724	8.14	No	Yes	1	5	6
17	R:R:N86	R:R:W93	23.7096	4.52	No	Yes	1	5	9
18	R:R:N175	R:R:W93	44.2335	4.52	Yes	Yes	0	4	9
19	R:R:D92	R:R:N175	10.0329	1.35	No	Yes	0	4	4
20	R:R:N86	R:R:W91	13.0683	10.17	No	Yes	1	5	4
21	L:L:?1	R:R:L104	12.3479	8.92	Yes	No	1	0	5
22	R:R:L104	R:R:M103	16.303	8.48	No	Yes	0	5	5
23	R:R:M103	R:R:W93	32.0674	5.82	Yes	Yes	0	5	9
24	L:L:?1	R:R:L107	41.7681	11.15	Yes	Yes	1	0	6
25	R:R:L107	R:R:M103	18.7614	5.65	Yes	Yes	0	6	5
26	L:L:?1	R:R:Y284	45.1252	13.22	Yes	Yes	1	0	7
27	R:R:E37	R:R:Y284	18.0235	5.61	Yes	Yes	0	7	7
28	R:R:L107	R:R:L76	36.0365	4.15	Yes	No	1	6	7
29	R:R:L76	R:R:S287	68.9607	6.01	No	No	0	7	8
30	R:R:D73	R:R:S287	67.8626	4.42	Yes	No	0	9	8
31	R:R:D73	R:R:N45	11.8024	5.39	Yes	No	0	9	9
32	R:R:L76	R:R:Y284	34.4314	5.86	No	Yes	1	7	7
33	R:R:D73	R:R:L69	63.4949	8.14	Yes	No	3	9	9
34	R:R:L69	R:R:Y295	61.9597	3.52	No	Yes	3	9	7
35	R:R:F301	R:R:Y295	37.264	6.19	Yes	Yes	0	9	7
36	R:R:F301	R:R:I51	16.3519	5.02	Yes	No	0	9	7
37	R:R:F304	R:R:I51	11.1904	5.02	No	No	0	4	7
38	L:L:?1	R:R:H189	76.1505	7.25	Yes	Yes	1	0	5
39	R:R:H161	R:R:H189	100	3.58	No	Yes	0	7	5
40	R:R:H161	R:R:W188	97.9053	4.23	No	No	0	7	5
41	R:R:L158	R:R:W188	49.1292	4.56	No	No	0	5	5
42	R:R:L158	R:R:Q112	45.6812	5.32	No	No	0	5	7
43	R:R:Q112	R:R:T155	88.96	4.25	No	No	0	7	7
44	R:R:M109	R:R:T155	84.9315	4.52	Yes	No	0	5	7
45	R:R:M109	R:R:W152	64.3831	4.65	Yes	Yes	2	5	9
46	R:R:N68	R:R:W152	39.1348	5.65	No	Yes	2	9	9
47	R:R:N68	R:R:S148	37.3164	8.94	No	No	0	9	8
48	R:R:I64	R:R:S148	35.0154	3.1	Yes	No	0	7	8
49	R:R:M192	R:R:W188	47.8144	12.8	No	No	0	5	5
50	R:R:M192	R:R:Q112	45.5134	9.52	No	No	0	5	7
51	R:R:I64	R:R:W59	21.1533	11.74	Yes	No	0	7	6
52	R:R:R63	R:R:W59	18.8033	2	No	No	0	7	6
53	R:R:R63	R:R:S62	16.4464	3.95	No	No	0	7	8
54	R:R:L66	R:R:Y295	14.2258	8.21	No	Yes	0	8	7
55	R:R:F117	R:R:W152	18.5725	17.04	No	Yes	2	8	9
56	R:R:D290	R:R:D73	13.5928	7.98	No	Yes	0	9	9
57	R:R:N175	R:R:P168	26.9094	6.52	Yes	No	0	4	4
58	R:R:D97	R:R:P168	22.657	9.66	Yes	No	0	3	4
59	L:L:?1	R:R:R111	68.0025	8.8	Yes	No	1	0	8
60	R:R:E196	R:R:R111	65.4707	8.14	No	No	1	5	8
61	R:R:E196	R:R:I115	65.1769	6.83	No	No	0	5	8
62	R:R:I115	R:R:P200	49.8147	3.39	No	No	0	8	9
63	R:R:F244	R:R:I115	33.9488	8.79	Yes	No	0	8	8
64	R:R:F117	R:R:L151	16.6911	4.87	No	No	0	8	7
65	R:R:P200	R:R:T119	47.4297	6.99	No	No	0	9	7
66	R:R:D124	R:R:S62	11.7114	1.47	No	No	0	8	8
67	R:R:I203	R:R:T119	46.2267	3.04	No	No	0	7	7
68	R:R:C207	R:R:I203	45.0168	1.64	No	No	0	8	7
69	R:R:C207	R:R:Y126	42.5759	6.72	No	Yes	0	8	7
70	R:R:I211	R:R:Y126	26.0176	2.42	No	Yes	0	8	7
71	R:R:I211	R:R:V129	24.6958	9.22	No	No	0	8	8
72	R:R:L215	R:R:V129	23.3564	4.47	No	No	0	8	8
73	R:R:I147	R:R:L151	11.9562	2.85	No	No	0	5	7
74	R:R:E190	R:R:H189	18.1459	3.69	Yes	Yes	1	4	5
75	R:R:F240	R:R:F244	23.4858	7.5	Yes	Yes	0	9	8
76	R:R:F197	R:R:F240	11.2428	5.36	Yes	Yes	5	8	9
77	R:R:I230	R:R:L215	13.8551	7.14	No	No	0	6	8
78	R:R:F244	R:R:N286	15.3133	4.83	Yes	Yes	0	8	9
79	R:R:D290	R:R:N286	12.187	5.39	No	Yes	0	9	9
80	R:R:F180	R:R:H189	14.2223	7.92	Yes	Yes	1	3	5
81	R:R:E190	R:R:R251	12.5647	5.82	Yes	Yes	1	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	10.03	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y87	3.78	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W91	5.5	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L104	8.92	1	Yes	No	0	5	0	1
L:L:?1	R:R:L107	11.15	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:A108	3.81	1	Yes	No	0	4	0	1
L:L:?1	R:R:R111	8.8	1	Yes	No	0	8	0	1
L:L:?1	R:R:S179	9.67	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F180	15.69	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:H189	7.25	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L280	14.49	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	13.22	1	Yes	Yes	0	7	0	1
R:R:V20	R:R:W91	3.68	0	No	Yes	2	4	2	1
R:R:I26	R:R:W91	3.52	0	No	Yes	5	4	2	1
R:R:L30	R:R:Y87	10.55	0	No	Yes	5	6	2	1
R:R:L34	R:R:L80	4.15	0	No	No	8	8	2	2
R:R:L34	R:R:Y87	3.52	0	No	Yes	8	6	2	1
R:R:E37	R:R:Y284	5.61	0	Yes	Yes	7	7	2	1
R:R:L107	R:R:L76	4.15	1	Yes	No	6	7	1	2
R:R:L76	R:R:Y284	5.86	1	No	Yes	7	7	2	1
R:R:L80	R:R:Y284	8.21	0	No	Yes	8	7	2	1
R:R:L83	R:R:Y87	4.69	1	No	Yes	6	6	1	1
R:R:L83	R:R:Y284	3.52	1	No	Yes	6	7	1	1
R:R:N86	R:R:Y87	8.14	1	No	Yes	5	6	2	1
R:R:N86	R:R:W91	10.17	1	No	Yes	5	4	2	1
R:R:W91	R:R:Y87	7.72	1	Yes	Yes	4	6	1	1
R:R:F277	R:R:Y87	5.16	1	No	Yes	5	6	2	1
R:R:F277	R:R:W91	8.02	1	No	Yes	5	4	2	1
R:R:L104	R:R:M103	8.48	1	No	Yes	5	5	1	2
R:R:L107	R:R:M103	5.65	1	Yes	Yes	6	5	1	2
R:R:L104	R:R:S179	4.5	1	No	Yes	5	4	1	1
R:R:L107	R:R:Y284	3.52	1	Yes	Yes	6	7	1	1
R:R:F193	R:R:R111	10.69	1	No	No	6	8	2	1
R:R:E196	R:R:R111	8.14	1	No	No	5	8	2	1
R:R:H161	R:R:H189	3.58	0	No	Yes	7	5	2	1
R:R:F180	R:R:S179	5.28	1	Yes	Yes	3	4	1	1
R:R:H189	R:R:S179	5.58	1	Yes	Yes	5	4	1	1
R:R:F180	R:R:H189	7.92	1	Yes	Yes	3	5	1	1
R:R:F180	R:R:R251	6.41	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	11.79	1	Yes	Yes	3	4	1	2
R:R:E190	R:R:H189	3.69	1	Yes	Yes	4	5	2	1
R:R:E190	R:R:R251	5.82	1	Yes	Yes	4	5	2	2
R:R:E196	R:R:F193	4.66	1	No	No	5	6	2	2
R:R:F276	R:R:R251	16.03	1	Yes	Yes	4	5	2	2
R:R:F276	R:R:L280	8.53	1	Yes	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8J6J_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	295
Number of Links	334
Number of Hubs	39
Number of Links mediated by Hubs	156
Number of Communities	9
Number of Nodes involved in Communities	65
Number of Links involved in Communities	88

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	76767
Length Of Smallest Path	3
Average Path Length	14.5902
Length of Longest Path	37
Minimum Path Strength	1.26
Average Path Strength	6.15634
Maximum Path Strength	19.015
Minimum Path Correlation	0.7
Average Path Correlation	0.933706
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	49.9658
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.4636
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • protein localization • positive regulation of cell communication • regulation of localization • establishment of protein localization • system process • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • cellular macromolecule localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • cellular localization • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • regulation of cellular localization • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	OKL
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	OKL
Name	8-chloranyl-3-pentyl-7H-purine-2,6-dione
Synonyms
Identifier
Formula	C10 H13 Cl N4 O2
Molecular Weight	256.689
SMILES
PubChem	46215799
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8J6J_nogp_Chain_R M N R H H L Q D H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F P N F F S T L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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