Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8I7W | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo Sapiens | GSK256073 | - | Gi1/Beta1/Gamma2 | 3.39 | 2024-02-07 | 10.1038/s41467-023-42764-8 |
![](/psngpcr/ligands/OKL/OKL_8I7W_L_L_1.png)
A 2D representation of the interactions of OKL in 8I7W colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:R22 | R:R:W91 | 4 | 0 | No | Yes | 3 | 4 | 2 | 1 | R:R:I26 | R:R:W91 | 7.05 | 0 | No | Yes | 5 | 4 | 2 | 1 | R:R:L30 | R:R:Y87 | 8.21 | 0 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:E37 | R:R:Y284 | 3.37 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:L76 | R:R:Y284 | 7.03 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:C79 | R:R:L107 | 3.17 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:L80 | R:R:L83 | 5.54 | 1 | No | Yes | 8 | 6 | 2 | 1 | R:R:L80 | R:R:Y284 | 8.21 | 1 | No | Yes | 8 | 7 | 2 | 1 | R:R:L107 | R:R:L83 | 5.54 | 1 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:L83 | R:R:Y284 | 3.52 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L83 | 7.89 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N86 | R:R:Y87 | 4.65 | 1 | No | Yes | 5 | 6 | 1 | 1 | R:R:N86 | R:R:W93 | 7.91 | 1 | No | Yes | 5 | 9 | 1 | 2 | L:L:?1 | R:R:N86 | 5.59 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:W91 | R:R:Y87 | 9.65 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:Y87 | 9.54 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F277 | R:R:W91 | 10.02 | 0 | No | Yes | 5 | 4 | 2 | 1 | L:L:?1 | R:R:W91 | 3.71 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:C177 | R:R:W93 | 7.84 | 1 | No | Yes | 9 | 9 | 2 | 2 | R:R:C177 | R:R:L104 | 4.76 | 1 | No | No | 9 | 5 | 2 | 1 | R:R:L104 | R:R:S179 | 3 | 1 | No | Yes | 5 | 4 | 1 | 1 | L:L:?1 | R:R:L104 | 7.89 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:L107 | R:R:Y284 | 4.69 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L107 | 6.76 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F180 | R:R:R111 | 4.28 | 1 | Yes | No | 3 | 8 | 2 | 1 | R:R:R111 | R:R:Y284 | 3.09 | 1 | No | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:R111 | 12.86 | 1 | Yes | No | 0 | 8 | 0 | 1 | R:R:L162 | R:R:S179 | 3 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | R:R:H189 | R:R:L162 | 15.43 | 1 | Yes | Yes | 5 | 4 | 2 | 2 | L:L:?1 | R:R:S178 | 6.11 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:H189 | R:R:S179 | 4.18 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | L:L:?1 | R:R:S179 | 8.56 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:F180 | R:R:H189 | 9.05 | 1 | Yes | Yes | 3 | 5 | 2 | 2 | R:R:F180 | R:R:L280 | 6.09 | 1 | Yes | No | 3 | 5 | 2 | 1 | L:L:?1 | R:R:L280 | 9.01 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:T283 | R:R:Y284 | 4.99 | 0 | No | Yes | 8 | 7 | 2 | 1 | L:L:?1 | R:R:Y284 | 8.59 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:L176 | R:R:S178 | 1.5 | 0 | Yes | No | 4 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 7.86 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 38.00 | Average Links Mediated by Hubs In Shell | 37.00 |
| ![](/psngpcr/ligands/OKL/OKL_8I7W_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/OKL/OKL_8I7W_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8IHB | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo Sapiens | GSK256073 | - | Gi1/Beta1/Gamma2 | 2.85 | 2023-09-13 | 10.1038/s41467-023-41650-7 |
![](/psngpcr/ligands/OKL/OKL_8IHB_L_L_1.png)
A 2D representation of the interactions of OKL in 8IHB colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I26 | R:R:L30 | 5.71 | 2 | No | Yes | 5 | 5 | 2 | 2 | R:R:I26 | R:R:Y87 | 4.84 | 2 | No | Yes | 5 | 6 | 2 | 1 | R:R:L30 | R:R:Y87 | 12.89 | 2 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:E37 | R:R:Y284 | 4.49 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:L76 | R:R:Y284 | 4.69 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:L80 | R:R:Y284 | 4.69 | 0 | No | Yes | 8 | 7 | 2 | 1 | R:R:L107 | R:R:L83 | 5.54 | 2 | Yes | No | 6 | 6 | 1 | 1 | R:R:L83 | R:R:Y284 | 3.52 | 2 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L83 | 9.71 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:N86 | R:R:Y87 | 3.49 | 2 | No | Yes | 5 | 6 | 2 | 1 | R:R:N86 | R:R:W91 | 3.39 | 2 | No | Yes | 5 | 4 | 2 | 1 | R:R:N86 | R:R:W93 | 6.78 | 2 | No | Yes | 5 | 9 | 2 | 2 | R:R:W91 | R:R:Y87 | 8.68 | 2 | Yes | Yes | 4 | 6 | 1 | 1 | R:R:F277 | R:R:Y87 | 4.13 | 2 | Yes | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:Y87 | 12.79 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:L176 | R:R:W91 | 7.97 | 0 | No | Yes | 4 | 4 | 2 | 1 | R:R:S178 | R:R:W91 | 4.94 | 2 | No | Yes | 4 | 4 | 1 | 1 | R:R:F277 | R:R:W91 | 12.03 | 2 | Yes | Yes | 5 | 4 | 1 | 1 | L:L:?1 | R:R:W91 | 3.55 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:M103 | R:R:W93 | 3.49 | 2 | Yes | Yes | 5 | 9 | 1 | 2 | R:R:L107 | R:R:M103 | 4.24 | 2 | Yes | Yes | 6 | 5 | 1 | 1 | L:L:?1 | R:R:M103 | 4.41 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:L104 | 5.39 | 2 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:L107 | 7.55 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F193 | R:R:R111 | 4.28 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:E196 | R:R:R111 | 8.14 | 0 | No | Yes | 5 | 8 | 2 | 1 | R:R:R111 | R:R:Y284 | 4.12 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:R111 | 4.73 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:S178 | 4.68 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:H189 | R:R:S179 | 8.37 | 0 | No | No | 5 | 4 | 2 | 1 | L:L:?1 | R:R:S179 | 4.68 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:F180 | R:R:H189 | 9.05 | 2 | Yes | No | 3 | 5 | 1 | 2 | R:R:E190 | R:R:F180 | 4.66 | 2 | Yes | Yes | 4 | 3 | 2 | 1 | R:R:F180 | R:R:F193 | 7.5 | 2 | Yes | No | 3 | 6 | 1 | 2 | R:R:F180 | R:R:F276 | 8.57 | 2 | Yes | Yes | 3 | 4 | 1 | 2 | R:R:F180 | R:R:L280 | 3.65 | 2 | Yes | No | 3 | 5 | 1 | 1 | L:L:?1 | R:R:F180 | 8.54 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:D273 | R:R:F277 | 5.97 | 0 | No | Yes | 4 | 5 | 2 | 1 | R:R:F276 | R:R:F277 | 7.5 | 0 | Yes | Yes | 4 | 5 | 2 | 1 | L:L:?1 | R:R:F277 | 4.75 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L280 | R:R:T283 | 4.42 | 2 | No | No | 5 | 8 | 1 | 2 | L:L:?1 | R:R:L280 | 14.02 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:T283 | R:R:Y284 | 4.99 | 0 | No | Yes | 8 | 7 | 2 | 1 | L:L:?1 | R:R:Y284 | 13.7 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:C79 | R:R:L107 | 3.17 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:P31 | R:R:Y87 | 2.78 | 0 | Yes | Yes | 6 | 6 | 2 | 1 | R:R:F82 | R:R:M103 | 2.49 | 0 | No | Yes | 6 | 5 | 2 | 1 | R:R:S178 | R:R:S181 | 1.63 | 2 | No | No | 4 | 4 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 8.00 | Average Interaction Strength | 7.58 | Average Nodes In Shell | 33.00 | Average Hubs In Shell | 14.00 | Average Links In Shell | 48.00 | Average Links Mediated by Hubs In Shell | 45.00 |
| ![](/psngpcr/ligands/OKL/OKL_8IHB_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/OKL/OKL_8IHB_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8IYW | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo Sapiens | GSK256073 | - | Go/Beta1/Gamma2 | 3.45 | 2024-03-06 | 10.1038/s41467-024-46239-2 |
![](/psngpcr/ligands/OKL/OKL_8IYW_L_L_1.png)
A 2D representation of the interactions of OKL in 8IYW colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I26 | R:R:L30 | 2.85 | 2 | Yes | Yes | 5 | 5 | 2 | 2 | R:R:I26 | R:R:Y87 | 2.42 | 2 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:I26 | R:R:W91 | 5.87 | 2 | Yes | Yes | 5 | 4 | 2 | 2 | R:R:L30 | R:R:L34 | 2.77 | 2 | Yes | Yes | 5 | 8 | 2 | 2 | R:R:L30 | R:R:Y87 | 11.72 | 2 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:E37 | R:R:L34 | 3.98 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:L34 | R:R:L80 | 13.84 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:L34 | R:R:L83 | 4.15 | 2 | Yes | Yes | 8 | 6 | 2 | 1 | R:R:L34 | R:R:Y284 | 4.69 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:E37 | R:R:Y284 | 4.49 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:L76 | R:R:Y284 | 10.55 | 2 | No | Yes | 7 | 7 | 2 | 1 | R:R:L76 | R:R:S287 | 3 | 2 | No | No | 7 | 8 | 2 | 2 | R:R:L80 | R:R:L83 | 2.77 | 2 | Yes | Yes | 8 | 6 | 2 | 1 | R:R:L80 | R:R:Y284 | 2.34 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:L83 | R:R:Y87 | 8.21 | 2 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:L83 | R:R:M103 | 4.24 | 2 | Yes | No | 6 | 5 | 1 | 2 | R:R:L107 | R:R:L83 | 5.54 | 2 | No | Yes | 6 | 6 | 1 | 1 | R:R:L83 | R:R:Y284 | 4.69 | 2 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L83 | 9.23 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N86 | R:R:Y87 | 9.3 | 2 | No | Yes | 5 | 6 | 1 | 1 | R:R:N86 | R:R:W93 | 9.04 | 2 | No | Yes | 5 | 9 | 1 | 2 | L:L:?1 | R:R:N86 | 3.43 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:W91 | R:R:Y87 | 8.68 | 2 | Yes | Yes | 4 | 6 | 2 | 1 | R:R:F277 | R:R:Y87 | 6.19 | 2 | Yes | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:Y87 | 13.68 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F277 | R:R:W91 | 17.04 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | R:R:C100 | R:R:W93 | 5.22 | 2 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:M103 | R:R:W93 | 3.49 | 2 | No | Yes | 5 | 9 | 2 | 2 | R:R:C177 | R:R:W93 | 11.75 | 2 | No | Yes | 9 | 9 | 1 | 2 | R:R:C100 | R:R:M167 | 8.1 | 2 | Yes | Yes | 9 | 3 | 2 | 2 | R:R:C100 | R:R:C177 | 7.28 | 2 | Yes | No | 9 | 9 | 2 | 1 | R:R:L104 | R:R:L162 | 6.92 | 0 | No | No | 5 | 4 | 1 | 2 | R:R:L104 | R:R:M167 | 2.83 | 0 | No | Yes | 5 | 3 | 1 | 2 | L:L:?1 | R:R:L104 | 10.38 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:L107 | R:R:Y284 | 9.38 | 2 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L107 | 9.23 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F193 | R:R:R111 | 5.34 | 2 | No | No | 6 | 8 | 2 | 1 | R:R:R111 | R:R:T283 | 7.76 | 0 | No | No | 8 | 8 | 1 | 2 | L:L:?1 | R:R:R111 | 3.04 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:H189 | R:R:L162 | 7.71 | 2 | Yes | No | 5 | 4 | 2 | 2 | R:R:K165 | R:R:M167 | 5.76 | 0 | No | Yes | 4 | 3 | 2 | 2 | R:R:K165 | R:R:S179 | 3.06 | 0 | No | Yes | 4 | 4 | 2 | 1 | R:R:L176 | R:R:S178 | 9.01 | 0 | No | No | 4 | 4 | 2 | 1 | L:L:?1 | R:R:C177 | 3.97 | 2 | Yes | No | 0 | 9 | 0 | 1 | L:L:?1 | R:R:S178 | 8.76 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:F180 | R:R:S179 | 3.96 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | R:R:H189 | R:R:S179 | 8.37 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | L:L:?1 | R:R:S179 | 2.5 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:F180 | R:R:H189 | 4.53 | 2 | Yes | Yes | 3 | 5 | 1 | 2 | R:R:E190 | R:R:F180 | 5.83 | 2 | Yes | Yes | 4 | 3 | 2 | 1 | R:R:F180 | R:R:F276 | 6.43 | 2 | Yes | Yes | 3 | 4 | 1 | 2 | L:L:?1 | R:R:F180 | 9.14 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:E190 | R:R:H189 | 3.69 | 2 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:F193 | R:R:S247 | 6.61 | 2 | No | No | 6 | 6 | 2 | 2 | R:R:F193 | R:R:L280 | 2.44 | 2 | No | No | 6 | 5 | 2 | 1 | R:R:L280 | R:R:S247 | 3 | 2 | No | No | 5 | 6 | 1 | 2 | R:R:F276 | R:R:F277 | 4.29 | 0 | Yes | Yes | 4 | 5 | 2 | 1 | L:L:?1 | R:R:F277 | 4.06 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:L280 | 6.92 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:T283 | R:R:Y284 | 2.5 | 0 | No | Yes | 8 | 7 | 2 | 1 | R:R:S287 | R:R:Y284 | 2.54 | 2 | No | Yes | 8 | 7 | 2 | 1 | L:L:?1 | R:R:Y284 | 8.79 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 7.16 | Average Nodes In Shell | 35.00 | Average Hubs In Shell | 19.00 | Average Links In Shell | 62.00 | Average Links Mediated by Hubs In Shell | 54.00 |
| ![](/psngpcr/ligands/OKL/OKL_8IYW_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/OKL/OKL_8IYW_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8J6J | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo Sapiens | GSK256073 | - | Gi1/Beta1/Gamma2 | 2.8 | 2024-01-10 | 10.1016/j.celrep.2023.113406 |
![](/psngpcr/ligands/OKL/OKL_8J6J_L_L_1.png)
A 2D representation of the interactions of OKL in 8J6J colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V20 | R:R:W91 | 3.68 | 0 | No | Yes | 2 | 4 | 2 | 1 | R:R:I26 | R:R:L30 | 2.85 | 0 | Yes | Yes | 5 | 5 | 2 | 2 | R:R:I26 | R:R:W91 | 3.52 | 0 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:L30 | R:R:Y87 | 10.55 | 0 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:L34 | R:R:L80 | 4.15 | 0 | No | No | 8 | 8 | 2 | 2 | R:R:L34 | R:R:Y87 | 3.52 | 0 | No | Yes | 8 | 6 | 2 | 1 | R:R:E37 | R:R:Y284 | 5.61 | 0 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:L107 | R:R:L76 | 4.15 | 2 | Yes | No | 6 | 7 | 1 | 2 | R:R:L76 | R:R:Y284 | 5.86 | 2 | No | Yes | 7 | 7 | 2 | 1 | R:R:C79 | R:R:L107 | 3.17 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:L80 | R:R:Y284 | 8.21 | 0 | No | Yes | 8 | 7 | 2 | 1 | R:R:L83 | R:R:Y87 | 4.69 | 2 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:L107 | R:R:L83 | 2.77 | 2 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:L83 | R:R:Y284 | 3.52 | 2 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L83 | 9.08 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N86 | R:R:Y87 | 8.14 | 2 | No | Yes | 5 | 6 | 2 | 1 | R:R:N86 | R:R:W91 | 10.17 | 2 | No | Yes | 5 | 4 | 2 | 1 | R:R:W91 | R:R:Y87 | 7.72 | 2 | Yes | Yes | 4 | 6 | 1 | 1 | R:R:F277 | R:R:Y87 | 5.16 | 2 | No | Yes | 5 | 6 | 2 | 1 | L:L:?1 | R:R:Y87 | 3.42 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F277 | R:R:W91 | 8.02 | 2 | No | Yes | 5 | 4 | 2 | 1 | L:L:?1 | R:R:W91 | 4.98 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:C100 | R:R:L104 | 3.17 | 2 | Yes | Yes | 9 | 5 | 2 | 1 | R:R:L104 | R:R:M103 | 8.48 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:L107 | R:R:M103 | 5.65 | 2 | Yes | Yes | 6 | 5 | 1 | 2 | R:R:L104 | R:R:S179 | 4.5 | 2 | Yes | Yes | 5 | 4 | 1 | 1 | L:L:?1 | R:R:L104 | 8.07 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L107 | R:R:Y284 | 3.52 | 2 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L107 | 10.09 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:A108 | R:R:T159 | 3.36 | 0 | No | Yes | 4 | 7 | 1 | 2 | L:L:?1 | R:R:A108 | 3.45 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:F193 | R:R:R111 | 10.69 | 2 | No | Yes | 6 | 8 | 2 | 1 | R:R:E196 | R:R:R111 | 8.14 | 2 | No | Yes | 5 | 8 | 2 | 1 | R:R:F244 | R:R:R111 | 3.21 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | L:L:?1 | R:R:R111 | 7.97 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:H161 | R:R:H189 | 3.58 | 0 | No | Yes | 7 | 5 | 2 | 1 | R:R:F180 | R:R:S179 | 5.28 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | R:R:H189 | R:R:S179 | 5.58 | 2 | Yes | Yes | 5 | 4 | 1 | 1 | L:L:?1 | R:R:S179 | 8.75 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:F180 | R:R:H189 | 7.92 | 2 | Yes | Yes | 3 | 5 | 1 | 1 | R:R:F180 | R:R:R251 | 6.41 | 2 | Yes | Yes | 3 | 5 | 1 | 2 | R:R:F180 | R:R:F276 | 11.79 | 2 | Yes | Yes | 3 | 4 | 1 | 2 | L:L:?1 | R:R:F180 | 14.2 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:E190 | R:R:H189 | 3.69 | 2 | Yes | Yes | 4 | 5 | 2 | 1 | L:L:?1 | R:R:H189 | 6.56 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:E190 | R:R:R251 | 5.82 | 2 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:E196 | R:R:F193 | 4.66 | 2 | No | No | 5 | 6 | 2 | 2 | R:R:F276 | R:R:R251 | 16.03 | 2 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:F276 | R:R:L280 | 8.53 | 2 | Yes | No | 4 | 5 | 2 | 1 | L:L:?1 | R:R:L280 | 13.11 | 2 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:Y284 | 11.96 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 10.00 | Average Interaction Strength | 8.47 | Average Nodes In Shell | 33.00 | Average Hubs In Shell | 21.00 | Average Links In Shell | 51.00 | Average Links Mediated by Hubs In Shell | 49.00 |
| ![](/psngpcr/ligands/OKL/OKL_8J6J_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/OKL/OKL_8J6J_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8K5D | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo Sapiens | GSK256073 | - | - | 3.74 | 2023-11-22 | 10.1038/s41467-023-42764-8 |
![](/psngpcr/ligands/OKL/OKL_8K5D_L_L_1.png)
A 2D representation of the interactions of OKL in 8K5D colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:R22 | R:R:W91 | 4 | 0 | No | Yes | 3 | 4 | 2 | 1 | R:R:I26 | R:R:W91 | 7.05 | 0 | No | Yes | 5 | 4 | 2 | 1 | R:R:L30 | R:R:Y87 | 8.21 | 0 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:E37 | R:R:Y284 | 3.37 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:L76 | R:R:Y284 | 7.03 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:C79 | R:R:L107 | 3.17 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:L80 | R:R:L83 | 5.54 | 1 | No | Yes | 8 | 6 | 2 | 1 | R:R:L80 | R:R:Y284 | 8.21 | 1 | No | Yes | 8 | 7 | 2 | 1 | R:R:L107 | R:R:L83 | 5.54 | 1 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:L83 | R:R:Y284 | 3.52 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L83 | 7.89 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N86 | R:R:Y87 | 4.65 | 1 | No | Yes | 5 | 6 | 1 | 1 | R:R:N86 | R:R:W93 | 7.91 | 1 | No | Yes | 5 | 9 | 1 | 2 | L:L:?1 | R:R:N86 | 5.59 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:W91 | R:R:Y87 | 9.65 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:Y87 | 9.54 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F277 | R:R:W91 | 10.02 | 0 | No | Yes | 5 | 4 | 2 | 1 | L:L:?1 | R:R:W91 | 3.71 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:C177 | R:R:W93 | 9.14 | 1 | No | Yes | 9 | 9 | 2 | 2 | R:R:C177 | R:R:L104 | 4.76 | 1 | No | No | 9 | 5 | 2 | 1 | R:R:L104 | R:R:S179 | 3 | 1 | No | Yes | 5 | 4 | 1 | 1 | L:L:?1 | R:R:L104 | 7.89 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:L107 | R:R:Y284 | 4.69 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L107 | 6.76 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F180 | R:R:R111 | 4.28 | 1 | Yes | No | 3 | 8 | 2 | 1 | R:R:R111 | R:R:Y284 | 3.09 | 1 | No | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:R111 | 12.86 | 1 | Yes | No | 0 | 8 | 0 | 1 | R:R:L162 | R:R:S179 | 3 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | R:R:H189 | R:R:L162 | 15.43 | 1 | Yes | Yes | 5 | 4 | 2 | 2 | L:L:?1 | R:R:S178 | 6.11 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:H189 | R:R:S179 | 4.18 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | L:L:?1 | R:R:S179 | 8.56 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:F180 | R:R:H189 | 9.05 | 1 | Yes | Yes | 3 | 5 | 2 | 2 | R:R:F180 | R:R:L280 | 6.09 | 1 | Yes | No | 3 | 5 | 2 | 1 | L:L:?1 | R:R:L280 | 9.01 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:T283 | R:R:Y284 | 4.99 | 0 | No | Yes | 8 | 7 | 2 | 1 | L:L:?1 | R:R:Y284 | 8.59 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:L176 | R:R:S178 | 1.5 | 0 | Yes | No | 4 | 4 | 2 | 1 | |
Statistics | Value |
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Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 7.86 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 38.00 | Average Links Mediated by Hubs In Shell | 37.00 |
| ![](/psngpcr/ligands/OKL/OKL_8K5D_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/OKL/OKL_8K5D_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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