psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	19.41	Yes	Yes	1	0	6
2	L:L:?1	R:R:L104	14.56	Yes	No	1	0	5
3	L:L:?1	R:R:L107	21.84	Yes	No	1	0	6
4	L:L:?1	R:R:R111	10.65	Yes	No	0	0	8
5	L:L:?1	R:R:C177	4.17	Yes	No	1	0	9
6	L:L:?1	R:R:S179	3.95	Yes	Yes	1	0	4
7	L:L:?1	R:R:F180	10.68	Yes	Yes	1	0	3
8	L:L:?1	R:R:Y284	9.25	Yes	Yes	1	0	7
9	R:R:D8	R:R:H9	22.69	No	No	0	6	6
10	R:R:D8	R:R:E267	3.9	No	No	0	6	2
11	R:R:F21	R:R:H9	15.84	No	No	0	2	6
12	R:R:C266	R:R:H9	8.85	No	No	0	7	6
13	R:R:F10	R:R:N17	9.67	No	No	0	7	5
14	R:R:L11	R:R:V20	7.45	No	No	6	8	2
15	R:R:L11	R:R:N171	6.87	No	No	6	8	1
16	R:R:C18	R:R:I13	4.91	No	No	0	9	3
17	R:R:I13	R:R:I169	5.89	No	No	0	3	1
18	R:R:D14	R:R:K15	11.06	No	No	0	5	3
19	R:R:D14	R:R:K165	9.68	No	No	0	5	4
20	R:R:K15	R:R:K16	11.49	No	No	0	3	4
21	R:R:K16	R:R:T185	16.52	No	No	0	4	2
22	R:R:H184	R:R:N17	12.75	No	No	0	3	5
23	R:R:C18	R:R:C183	7.28	No	No	0	9	1
24	R:R:C19	R:R:F21	4.19	No	No	0	4	2
25	R:R:C19	R:R:C266	7.28	No	No	0	4	7
26	R:R:N171	R:R:V20	7.39	No	No	6	1	2
27	R:R:F21	R:R:R270	7.48	No	No	0	2	1
28	R:R:R22	R:R:R90	10.66	No	No	0	3	4
29	R:R:D92	R:R:R22	5.96	No	No	0	4	3
30	R:R:D23	R:R:F25	5.97	No	No	7	4	6
31	R:R:D23	R:R:L274	5.43	No	No	7	4	1
32	R:R:F25	R:R:K28	4.96	No	No	0	6	3
33	R:R:F25	R:R:L274	7.31	No	No	7	6	1
34	R:R:I26	R:R:L30	5.71	No	Yes	0	5	5
35	R:R:R90	R:R:V27	10.46	No	No	0	4	3
36	R:R:K28	R:R:V29	4.55	No	No	0	3	5
37	R:R:L30	R:R:V29	4.47	Yes	No	0	5	5
38	R:R:L30	R:R:Y87	12.89	Yes	Yes	0	5	6
39	R:R:P31	R:R:P32	5.84	No	No	0	6	5
40	R:R:P31	R:R:Y87	4.17	No	Yes	0	6	6
41	R:R:L34	R:R:L83	4.15	No	Yes	1	8	6
42	R:R:L34	R:R:Y87	7.03	No	Yes	1	8	6
43	R:R:E37	R:R:M285	6.77	No	No	0	7	5
44	R:R:E37	R:R:M288	5.41	No	Yes	0	7	8
45	R:R:F38	R:R:L42	4.87	Yes	No	8	7	7
46	R:R:F38	R:R:I77	5.02	Yes	Yes	8	7	6
47	R:R:F38	R:R:P81	13	Yes	No	0	7	8
48	R:R:I77	R:R:L42	9.99	Yes	No	8	6	7
49	R:R:D73	R:R:N45	6.73	Yes	No	0	9	9
50	R:R:I77	R:R:N45	4.25	Yes	No	0	6	9
51	R:R:N45	R:R:P291	4.89	No	No	0	9	9
52	R:R:F296	R:R:L47	7.31	Yes	No	0	8	6
53	R:R:A48	R:R:Y295	4	No	Yes	0	9	7
54	R:R:F74	R:R:L49	6.09	No	No	0	7	7
55	R:R:F54	R:R:W50	11.02	Yes	No	9	4	4
56	R:R:H55	R:R:W50	7.41	No	No	9	5	4
57	R:R:H55	R:R:I51	3.98	No	No	0	5	7
58	R:R:F52	R:R:L56	8.53	Yes	No	4	7	5
59	R:R:F52	R:R:R63	4.28	Yes	Yes	4	7	7
60	R:R:F52	R:R:F67	9.65	Yes	No	0	7	6
61	R:R:F52	R:R:Y295	7.22	Yes	Yes	0	7	7
62	R:R:C53	R:R:F54	6.98	No	Yes	0	4	4
63	R:R:F54	R:R:H55	4.53	Yes	No	9	4	5
64	R:R:L56	R:R:R63	7.29	No	Yes	4	5	7
65	R:R:F301	R:R:L56	4.87	Yes	No	4	9	5
66	R:R:I139	R:R:S61	6.19	No	No	0	7	6
67	R:R:D124	R:R:S62	7.36	No	No	10	8	8
68	R:R:R128	R:R:S62	5.27	No	No	10	8	8
69	R:R:F301	R:R:R63	5.34	Yes	Yes	4	9	7
70	R:R:I64	R:R:N141	5.66	Yes	No	0	7	2
71	R:R:A144	R:R:I64	4.87	No	Yes	0	7	7
72	R:R:F65	R:R:V120	9.18	No	No	0	7	7
73	R:R:L66	R:R:Y295	14.07	No	Yes	0	8	7
74	R:R:F67	R:R:N68	6.04	No	Yes	0	6	9
75	R:R:F67	R:R:V71	6.55	No	No	0	6	6
76	R:R:F117	R:R:N68	15.71	Yes	Yes	5	8	9
77	R:R:N68	R:R:S148	7.45	Yes	No	5	9	8
78	R:R:N68	R:R:W152	4.52	Yes	Yes	5	9	9
79	R:R:D73	R:R:L69	5.43	Yes	No	3	9	9
80	R:R:D290	R:R:L69	4.07	Yes	No	3	9	9
81	R:R:A70	R:R:Y295	5.34	No	Yes	0	8	7
82	R:R:D73	R:R:S287	10.31	Yes	No	0	9	8
83	R:R:D290	R:R:D73	6.65	Yes	Yes	3	9	9
84	R:R:F74	R:R:I78	7.54	No	No	0	7	6
85	R:R:L75	R:R:N110	6.87	No	No	0	6	9
86	R:R:L76	R:R:N110	6.87	No	No	0	7	9
87	R:R:L76	R:R:Y284	5.86	No	Yes	0	7	7
88	R:R:I77	R:R:I78	4.42	Yes	No	0	6	6
89	R:R:C79	R:R:M103	4.86	No	No	0	6	5
90	R:R:C79	R:R:M106	4.86	No	No	0	6	5
91	R:R:L80	R:R:Y284	4.69	No	Yes	0	8	7
92	R:R:F82	R:R:W93	4.01	Yes	Yes	1	6	9
93	R:R:F82	R:R:F95	13.93	Yes	No	1	6	7
94	R:R:F82	R:R:P99	4.33	Yes	No	1	6	5
95	R:R:F82	R:R:M103	9.95	Yes	No	0	6	5
96	R:R:L83	R:R:Y87	15.24	Yes	Yes	1	6	6
97	R:R:L83	R:R:Y284	4.69	Yes	Yes	1	6	7
98	R:R:D85	R:R:F95	9.55	No	No	0	4	7
99	R:R:N86	R:R:W91	12.43	No	Yes	0	5	4
100	R:R:N86	R:R:W93	6.78	No	Yes	0	5	9
101	R:R:W91	R:R:Y87	6.75	Yes	Yes	0	4	6
102	R:R:R89	R:R:V88	7.85	Yes	No	0	4	3
103	R:R:K94	R:R:R89	22.28	No	Yes	0	3	4
104	R:R:S178	R:R:W91	4.94	No	Yes	0	4	4
105	R:R:F277	R:R:W91	12.03	No	Yes	0	5	4
106	R:R:A174	R:R:D92	6.18	No	No	0	2	4
107	R:R:F95	R:R:W93	13.03	No	Yes	1	7	9
108	R:R:P99	R:R:W93	4.05	No	Yes	1	5	9
109	R:R:C100	R:R:W93	10.45	No	Yes	1	9	9
110	R:R:N175	R:R:W93	5.65	No	Yes	0	4	9
111	R:R:C177	R:R:W93	20.89	No	Yes	1	9	9
112	R:R:D97	R:R:K166	8.3	No	No	0	3	4
113	R:R:D97	R:R:P168	11.27	No	Yes	0	3	4
114	R:R:I98	R:R:R101	6.26	No	No	0	2	6
115	R:R:I98	R:R:L102	4.28	No	No	0	2	5
116	R:R:C100	R:R:P168	5.65	No	Yes	0	9	4
117	R:R:C100	R:R:C177	7.28	No	No	1	9	9
118	R:R:L104	R:R:S179	4.5	No	Yes	1	5	4
119	R:R:F105	R:R:T159	6.49	No	No	0	6	7
120	R:R:F105	R:R:L163	18.27	No	No	0	6	5
121	R:R:M106	R:R:N110	4.21	No	No	0	5	9
122	R:R:L107	R:R:Y284	4.69	No	Yes	1	6	7
123	R:R:M109	R:R:W152	4.65	Yes	Yes	0	5	9
124	R:R:M109	R:R:T155	4.52	Yes	No	0	5	7
125	R:R:I156	R:R:M109	4.37	No	Yes	0	4	5
126	R:R:M109	R:R:T159	9.03	Yes	No	0	5	7
127	R:R:E196	R:R:R111	8.14	Yes	No	0	5	8
128	R:R:R111	R:R:T283	7.76	No	Yes	0	8	8
129	R:R:M192	R:R:Q112	10.88	No	No	0	5	7
130	R:R:E196	R:R:Q112	8.92	Yes	No	0	5	7
131	R:R:E196	R:R:I115	6.83	Yes	No	0	5	8
132	R:R:F244	R:R:I115	8.79	Yes	No	0	8	8
133	R:R:I116	R:R:L151	5.71	No	No	0	5	7
134	R:R:F117	R:R:S148	3.96	Yes	No	5	8	8
135	R:R:F117	R:R:L151	6.09	Yes	No	0	8	7
136	R:R:F117	R:R:W152	11.02	Yes	Yes	5	8	9
137	R:R:F240	R:R:L118	4.87	Yes	No	0	9	9
138	R:R:D290	R:R:L118	4.07	Yes	No	3	9	9
139	R:R:L118	R:R:Y294	9.38	No	Yes	3	9	9
140	R:R:P200	R:R:T119	5.25	No	No	0	9	7
141	R:R:I203	R:R:T119	4.56	No	No	0	7	7
142	R:R:I204	R:R:T119	4.56	No	No	0	8	7
143	R:R:R125	R:R:V121	7.85	No	No	0	9	9
144	R:R:D124	R:R:R128	13.1	No	No	10	8	8
145	R:R:I233	R:R:R125	5.01	No	No	0	7	9
146	R:R:R125	R:R:Y294	5.14	No	Yes	0	9	9
147	R:R:F127	R:R:Y126	5.16	Yes	Yes	2	5	7
148	R:R:V130	R:R:Y126	12.62	Yes	Yes	2	8	7
149	R:R:H131	R:R:Y126	7.62	No	Yes	2	7	7
150	R:R:F206	R:R:Y126	7.22	No	Yes	2	4	7
151	R:R:C207	R:R:Y126	9.41	No	Yes	0	8	7
152	R:R:R210	R:R:Y126	9.26	Yes	Yes	2	4	7
153	R:R:F127	R:R:H134	7.92	Yes	Yes	2	5	4
154	R:R:F127	R:R:L136	12.18	Yes	No	2	5	4
155	R:R:N137	R:R:R128	6.03	No	No	0	4	8
156	R:R:I211	R:R:V129	9.22	No	No	0	8	8
157	R:R:H131	R:R:V130	13.84	No	Yes	2	7	8
158	R:R:R210	R:R:V130	6.54	Yes	Yes	2	4	8
159	R:R:S214	R:R:V130	6.46	No	Yes	0	5	8
160	R:R:H133	R:R:P132	4.58	No	No	0	6	8
161	R:R:H134	R:R:L136	3.86	Yes	No	2	4	4
162	R:R:S140	R:R:T143	4.8	No	No	0	6	3
163	R:R:L158	R:R:W188	7.97	No	Yes	0	5	5
164	R:R:H161	R:R:L162	11.57	No	No	1	7	4
165	R:R:H161	R:R:W188	7.41	No	Yes	0	7	5
166	R:R:H161	R:R:H189	4.78	No	Yes	1	7	5
167	R:R:H189	R:R:L162	7.71	Yes	No	1	5	4
168	R:R:N175	R:R:P168	6.52	No	Yes	0	4	4
169	R:R:N175	R:R:Q170	5.28	No	No	0	4	1
170	R:R:L176	R:R:S178	6.01	No	No	0	4	4
171	R:R:S178	R:R:S181	4.89	No	No	0	4	4
172	R:R:F180	R:R:S179	3.96	Yes	Yes	1	3	4
173	R:R:H189	R:R:S179	4.18	Yes	Yes	1	5	4
174	R:R:F180	R:R:H189	12.44	Yes	Yes	1	3	5
175	R:R:E190	R:R:F180	5.83	No	Yes	1	4	3
176	R:R:F180	R:R:F193	11.79	Yes	Yes	1	3	6
177	R:R:F180	R:R:R251	9.62	Yes	Yes	1	3	5
178	R:R:F180	R:R:F276	9.65	Yes	Yes	1	3	4
179	R:R:I182	R:R:I254	4.42	Yes	No	0	3	4
180	R:R:I182	R:R:L258	4.28	Yes	No	11	3	3
181	R:R:I182	R:R:Y269	4.84	Yes	Yes	11	3	2
182	R:R:D273	R:R:I182	9.8	No	Yes	0	4	3
183	R:R:H184	R:R:T185	6.85	No	No	0	3	2
184	R:R:H184	R:R:T263	6.85	No	No	0	3	3
185	R:R:H189	R:R:Q187	4.95	Yes	No	0	5	2
186	R:R:M192	R:R:W188	16.29	No	Yes	0	5	5
187	R:R:E190	R:R:R251	13.96	No	Yes	1	4	5
188	R:R:E190	R:R:F255	8.16	No	No	1	4	5
189	R:R:E196	R:R:F193	7	Yes	Yes	0	5	6
190	R:R:F193	R:R:S247	3.96	Yes	No	0	6	6
191	R:R:F193	R:R:R251	6.41	Yes	Yes	1	6	5
192	R:R:F193	R:R:F276	4.29	Yes	Yes	1	6	4
193	R:R:I252	R:R:L194	4.28	No	No	0	6	4
194	R:R:L195	R:R:L199	4.15	No	No	0	4	4
195	R:R:F197	R:R:F198	5.36	Yes	No	12	8	5
196	R:R:F197	R:R:L201	9.74	Yes	Yes	0	8	7
197	R:R:F197	R:R:L245	6.09	Yes	No	0	8	6
198	R:R:F197	R:R:V248	9.18	Yes	No	12	8	8
199	R:R:F198	R:R:V248	3.93	No	No	12	5	8
200	R:R:L199	R:R:P200	4.93	No	No	0	4	9
201	R:R:I203	R:R:L199	4.28	No	No	0	7	4
202	R:R:L201	R:R:L205	5.54	Yes	No	0	7	4
203	R:R:F240	R:R:I204	7.54	Yes	No	0	9	8
204	R:R:F206	R:R:R210	9.62	No	Yes	2	4	4
205	R:R:I212	R:R:I230	4.42	No	No	0	5	6
206	R:R:L215	R:R:M220	5.65	No	No	13	8	3
207	R:R:I226	R:R:L215	5.71	No	No	13	6	8
208	R:R:D221	R:R:R216	8.34	No	No	0	3	4
209	R:R:Q217	R:R:R218	4.67	No	No	0	5	5
210	R:R:M220	R:R:R218	6.2	No	No	0	3	5
211	R:R:Q219	R:R:R222	7.01	No	No	0	3	3
212	R:R:I226	R:R:M220	4.37	No	No	13	6	3
213	R:R:D221	R:R:R222	10.72	No	No	0	3	3
214	R:R:H223	R:R:K225	13.1	No	No	0	4	5
215	R:R:F232	R:R:R228	5.34	No	No	0	7	7
216	R:R:P299	R:R:R228	14.41	No	No	0	5	7
217	R:R:F232	R:R:S297	9.25	No	No	0	7	6
218	R:R:V236	R:R:Y294	10.09	No	Yes	0	8	9
219	R:R:F240	R:R:F244	7.5	Yes	Yes	0	9	8
220	R:R:F244	R:R:T283	5.19	Yes	Yes	0	8	8
221	R:R:F244	R:R:N286	8.46	Yes	No	0	8	9
222	R:R:F282	R:R:P246	5.78	No	No	0	7	9
223	R:R:S247	R:R:T279	4.8	No	Yes	0	6	7
224	R:R:F276	R:R:V250	6.55	Yes	No	0	4	5
225	R:R:T279	R:R:V250	6.35	Yes	No	0	7	5
226	R:R:I254	R:R:R251	8.77	No	Yes	0	4	5
227	R:R:F255	R:R:R251	8.55	No	Yes	1	5	5
228	R:R:F276	R:R:R251	16.03	Yes	Yes	1	4	5
229	R:R:R253	R:R:V272	7.85	No	No	0	5	4
230	R:R:T260	R:R:W256	4.85	No	No	0	1	4
231	R:R:L257	R:R:V272	4.47	No	No	0	3	4
232	R:R:L258	R:R:T263	4.42	No	No	0	3	3
233	R:R:L258	R:R:Y269	10.55	No	Yes	11	3	2
234	R:R:S261	R:R:Y269	10.17	No	Yes	0	3	2
235	R:R:E267	R:R:N265	5.26	No	No	0	2	5
236	R:R:N265	R:R:V268	4.43	No	No	0	5	1
237	R:R:E267	R:R:R270	6.98	No	No	0	2	1
238	R:R:V268	R:R:Y269	3.79	No	Yes	0	1	2
239	R:R:F276	R:R:F277	7.5	Yes	No	0	4	5
240	R:R:I278	R:R:T279	4.56	No	Yes	0	6	7
241	R:R:L280	R:R:T283	5.9	No	Yes	1	5	8
242	R:R:L280	R:R:Y284	4.69	No	Yes	1	5	7
243	R:R:F282	R:R:M285	4.98	No	No	0	7	5
244	R:R:T283	R:R:Y284	7.49	Yes	Yes	1	8	7
245	R:R:N286	R:R:S287	4.47	No	No	0	9	8
246	R:R:D290	R:R:N286	13.46	Yes	No	0	9	9
247	R:R:L289	R:R:M288	4.24	No	Yes	0	7	8
248	R:R:D290	R:R:Y294	6.9	Yes	Yes	3	9	9
249	R:R:V293	R:R:Y294	3.79	No	Yes	0	8	9
250	R:R:Y294	R:R:Y295	5.96	Yes	Yes	0	9	7
251	R:R:F301	R:R:S298	3.96	Yes	No	0	9	8
252	R:R:F301	R:R:S300	9.25	Yes	No	0	9	5
253	R:R:F65	R:R:I147	3.77	No	No	0	7	5
254	R:R:F38	R:R:M84	3.73	Yes	No	0	7	7
255	R:R:F40	R:R:L36	3.65	No	No	0	6	4
256	R:R:F240	R:R:L201	3.65	Yes	Yes	0	9	7
257	R:R:G113	R:R:T155	3.64	No	No	0	7	7
258	R:R:D24	R:R:R90	3.57	No	No	0	4	4
259	R:R:D85	R:R:R89	3.57	No	Yes	0	4	4
260	R:R:D92	R:R:R89	3.57	No	Yes	0	4	4
261	R:R:L257	R:R:Y269	3.52	No	Yes	0	3	2
262	R:R:P246	R:R:T279	3.5	No	Yes	0	9	7
263	R:R:G35	R:R:M84	3.49	No	No	0	5	7
264	R:R:G41	R:R:M288	3.49	No	Yes	0	8	8
265	R:R:G44	R:R:L43	3.42	No	No	0	7	4
266	R:R:A144	R:R:S61	3.42	No	No	0	7	6
267	R:R:I98	R:R:P99	3.39	No	No	0	2	5
268	R:R:D97	R:R:G96	3.35	No	No	0	3	7
269	R:R:M167	R:R:P168	3.35	No	Yes	0	3	4
270	R:R:S114	R:R:S287	3.26	No	No	0	9	8
271	R:R:C243	R:R:M285	3.24	No	No	0	8	5
272	R:R:S181	R:R:V20	3.23	No	No	0	4	2
273	R:R:S297	R:R:V293	3.23	No	No	0	6	8
274	R:R:I233	R:R:S208	3.1	No	No	0	7	8
275	R:R:I252	R:R:V248	3.07	No	No	0	6	8
276	R:R:K60	R:R:S58	3.06	No	No	0	7	6
277	R:R:I139	R:R:T143	3.04	No	No	0	7	3
278	R:R:K164	R:R:V160	3.04	No	No	0	4	4
279	R:R:F296	R:R:G44	3.01	Yes	No	0	8	7
280	R:R:L30	R:R:S281	3	Yes	No	0	5	6
281	R:R:R210	R:R:W213	3	Yes	No	0	4	3
282	R:R:L151	R:R:V120	2.98	No	No	0	7	7
283	R:R:L215	R:R:V129	2.98	No	No	0	8	8
284	R:R:L201	R:R:V241	2.98	Yes	No	0	7	5
285	R:R:L245	R:R:V249	2.98	No	No	0	6	6
286	R:R:I212	R:R:I233	2.94	No	No	0	5	7
287	R:R:I13	R:R:M167	2.92	No	No	0	3	3
288	R:R:I51	R:R:L47	2.85	No	No	0	7	6
289	R:R:I146	R:R:L150	2.85	No	No	0	3	4
290	R:R:I154	R:R:L158	2.85	No	No	0	5	5
291	R:R:A48	R:R:F296	2.77	No	Yes	0	9	8
292	R:R:H223	R:R:I226	2.65	No	No	0	4	6
293	R:R:N265	R:R:Q264	2.64	No	No	0	5	3
294	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
295	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
296	R:R:H134	R:R:N137	2.55	Yes	No	0	4	4
297	R:R:I146	R:R:R142	2.51	No	No	0	3	4
298	R:R:I212	R:R:R216	2.51	No	No	0	5	4
299	R:R:F40	R:R:M288	2.49	No	Yes	0	6	8
300	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
301	R:R:I64	R:R:W59	2.35	Yes	No	0	7	6
302	R:R:G172	R:R:G173	2.11	No	No	0	3	4
303	R:R:G262	R:R:T263	1.82	No	No	0	4	3
304	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
305	R:R:A237	R:R:S208	1.71	No	No	0	7	8
306	R:R:G172	R:R:N171	1.7	No	No	0	3	1
307	R:R:A108	R:R:T159	1.68	No	No	0	4	7
308	R:R:C207	R:R:I203	1.64	No	No	0	8	7
309	R:R:C243	R:R:I242	1.64	No	No	0	8	5
310	R:R:A122	R:R:I204	1.62	No	No	0	9	8
311	R:R:A275	R:R:I278	1.62	No	No	0	5	6
312	R:R:A224	R:R:K227	1.61	No	No	0	3	4
313	R:R:V235	R:R:V239	1.6	No	No	0	5	7
314	R:R:V235	R:R:V293	1.6	No	No	0	5	8
315	R:R:S261	R:R:T260	1.6	No	No	0	3	1
316	R:R:T231	R:R:V235	1.59	No	No	0	6	5
317	R:R:I64	R:R:S148	1.55	Yes	No	0	7	8
318	R:R:I156	R:R:V160	1.54	No	No	0	4	4
319	R:R:H131	R:R:P132	1.53	No	No	0	7	8
320	R:R:L34	R:R:V33	1.49	No	No	0	8	5
321	R:R:A135	R:R:H134	1.46	No	Yes	0	5	4
322	R:R:A224	R:R:H223	1.46	No	No	0	3	4
323	R:R:R63	R:R:S58	1.32	Yes	No	0	7	6
324	R:R:R142	R:R:S140	1.32	No	No	0	4	6
325	R:R:E12	R:R:N17	1.31	No	No	0	5	5
326	R:R:F296	R:R:V292	1.31	Yes	No	0	8	6
327	R:R:A191	R:R:W188	1.3	No	Yes	0	3	5
328	R:R:F40	R:R:I39	1.26	No	No	0	6	5
329	R:R:F54	R:R:K57	1.24	Yes	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.8137	8	1	0
2	R:R:L30	6.5175	4	0	5
3	R:R:F38	6.655	4	8	7
4	R:R:F52	7.42	4	4	7
5	R:R:F54	5.9425	4	9	4
6	R:R:R63	4.5575	4	4	7
7	R:R:I64	3.6075	4	0	7
8	R:R:N68	8.43	4	5	9
9	R:R:D73	7.28	4	3	9
10	R:R:I77	5.92	4	8	6
11	R:R:F82	8.055	4	1	6
12	R:R:L83	10.8725	4	1	6
13	R:R:Y87	9.216	5	1	6
14	R:R:R89	9.3175	4	0	4
15	R:R:W91	9.0375	4	0	4
16	R:R:W93	9.26571	7	1	9
17	R:R:M109	5.6425	4	0	5
18	R:R:F117	9.195	4	5	8
19	R:R:Y126	7.67286	7	2	7
20	R:R:F127	6.97	4	2	5
21	R:R:V130	9.865	4	2	8
22	R:R:H134	3.9475	4	2	4
23	R:R:W152	5.695	4	5	9
24	R:R:P168	6.6975	4	0	4
25	R:R:S179	4.1475	4	1	4
26	R:R:F180	9.13857	7	1	3
27	R:R:I182	5.835	4	11	3
28	R:R:W188	8.2425	4	0	5
29	R:R:H189	6.812	5	1	5
30	R:R:F193	6.69	5	1	6
31	R:R:E196	7.7225	4	0	5
32	R:R:F197	7.5925	4	12	8
33	R:R:L201	4.724	5	0	7
34	R:R:R210	7.105	4	2	4
35	R:R:F240	5.89	4	0	9
36	R:R:F244	7.485	4	0	8
37	R:R:R251	10.5567	6	1	5
38	R:R:Y269	6.574	5	11	2
39	R:R:F276	8.804	5	1	4
40	R:R:T279	4.8025	4	0	7
41	R:R:T283	6.585	4	1	8
42	R:R:Y284	5.90857	7	1	7
43	R:R:M288	3.9075	4	0	8
44	R:R:D290	7.03	5	3	9
45	R:R:Y294	6.87667	6	3	9
46	R:R:Y295	7.318	5	0	7
47	R:R:F296	3.6	4	0	8
48	R:R:F301	5.855	4	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F180	23.162	10.68	Yes	Yes	1	0	3
2	R:R:I254	R:R:R251	40.6169	8.77	No	Yes	0	4	5
3	R:R:I182	R:R:I254	39.4472	4.42	Yes	No	0	3	4
4	R:R:I182	R:R:Y269	21.8271	4.84	Yes	Yes	11	3	2
5	R:R:V268	R:R:Y269	13.4805	3.79	No	Yes	0	1	2
6	R:R:N265	R:R:V268	12.1625	4.43	No	No	0	5	1
7	R:R:I182	R:R:L258	15.2503	4.28	Yes	No	11	3	3
8	R:R:L258	R:R:T263	14.6334	4.42	No	No	0	3	3
9	R:R:H184	R:R:T263	12.004	6.85	No	No	0	3	3
10	R:R:L83	R:R:Y87	20.5528	15.24	Yes	Yes	1	6	6
11	R:R:W91	R:R:Y87	12.5737	6.75	Yes	Yes	0	4	6
12	R:R:S178	R:R:W91	10.0051	4.94	No	Yes	0	4	4
13	L:L:?1	R:R:C177	63.5463	4.17	Yes	No	1	0	9
14	R:R:C100	R:R:C177	20.0405	7.28	No	No	1	9	9
15	R:R:C100	R:R:P168	19.309	5.65	No	Yes	0	9	4
16	R:R:M167	R:R:P168	11.3872	3.35	No	Yes	0	3	4
17	R:R:C177	R:R:W93	41.8979	20.89	No	Yes	1	9	9
18	R:R:F95	R:R:W93	24.3587	13.03	No	Yes	1	7	9
19	R:R:D85	R:R:F95	22.5147	9.55	No	No	0	4	7
20	R:R:D85	R:R:R89	20.2933	3.57	No	Yes	0	4	4
21	R:R:D92	R:R:R89	13.5884	3.57	No	Yes	0	4	4
22	R:R:L30	R:R:Y87	11.7344	12.89	Yes	Yes	0	5	6
23	R:R:F193	R:R:S247	18.8269	3.96	Yes	No	0	6	6
24	R:R:S247	R:R:T279	17.5965	4.8	No	Yes	0	6	7
25	R:R:P246	R:R:T279	19.8584	3.5	No	Yes	0	9	7
26	R:R:F282	R:R:P246	18.2404	5.78	No	No	0	7	9
27	R:R:F282	R:R:M285	16.6155	4.98	No	No	0	7	5
28	R:R:E37	R:R:M285	11.7007	6.77	No	No	0	7	5
29	R:R:E37	R:R:M288	10.0489	5.41	No	Yes	0	7	8
30	L:L:?1	R:R:R111	36.7976	10.65	Yes	No	0	0	8
31	R:R:R111	R:R:T283	36.929	7.76	No	Yes	0	8	8
32	R:R:F244	R:R:T283	100	5.19	Yes	Yes	0	8	8
33	R:R:F244	R:R:N286	71.195	8.46	Yes	No	0	8	9
34	R:R:N286	R:R:S287	10.2377	4.47	No	No	0	9	8
35	R:R:D73	R:R:N45	19.7607	6.73	Yes	No	0	9	9
36	R:R:I77	R:R:N45	16.2279	4.25	Yes	No	0	6	9
37	L:L:?1	R:R:Y284	38.746	9.25	Yes	Yes	1	0	7
38	R:R:T283	R:R:Y284	62.5855	7.49	Yes	Yes	1	8	7
39	R:R:D290	R:R:N286	61.5911	13.46	Yes	No	0	9	9
40	R:R:D290	R:R:D73	13.939	6.65	Yes	Yes	3	9	9
41	R:R:F240	R:R:F244	86.2599	7.5	Yes	Yes	0	9	8
42	R:R:F240	R:R:L118	68.4949	4.87	Yes	No	0	9	9
43	R:R:L118	R:R:Y294	65.4644	9.38	No	Yes	3	9	9
44	R:R:Y294	R:R:Y295	94.566	5.96	Yes	Yes	0	9	7
45	R:R:A48	R:R:Y295	21.5574	4	No	Yes	0	9	7
46	R:R:A48	R:R:F296	19.7977	2.77	No	Yes	0	9	8
47	R:R:D290	R:R:Y294	56.5448	6.9	Yes	Yes	3	9	9
48	R:R:F296	R:R:L47	12.6884	7.31	Yes	No	0	8	6
49	R:R:I51	R:R:L47	10.8984	2.85	No	No	0	7	6
50	R:R:F52	R:R:Y295	72.4524	7.22	Yes	Yes	0	7	7
51	R:R:F52	R:R:R63	10.5242	4.28	Yes	Yes	4	7	7
52	R:R:F52	R:R:F67	55.5773	9.65	Yes	No	0	7	6
53	R:R:F67	R:R:N68	52.6074	6.04	No	Yes	0	6	9
54	R:R:N68	R:R:S148	20.772	7.45	Yes	No	5	9	8
55	R:R:I64	R:R:S148	19.9562	1.55	Yes	No	0	7	8
56	R:R:A144	R:R:I64	14.5255	4.87	No	Yes	0	7	7
57	R:R:A144	R:R:S61	12.6985	3.42	No	No	0	7	6
58	R:R:F240	R:R:I204	39.8416	7.54	Yes	No	0	9	8
59	R:R:I204	R:R:T119	38.1055	4.56	No	No	0	8	7
60	R:R:I203	R:R:T119	34.1547	4.56	No	No	0	7	7
61	R:R:C207	R:R:I203	31.4209	1.64	No	No	0	8	7
62	R:R:C207	R:R:Y126	30.4568	9.41	No	Yes	0	8	7
63	R:R:F127	R:R:Y126	10.0421	5.16	Yes	Yes	2	5	7
64	R:R:F117	R:R:N68	10.1534	15.71	Yes	Yes	5	8	9
65	R:R:N68	R:R:W152	20.9911	4.52	Yes	Yes	5	9	9
66	R:R:M109	R:R:W152	18.3718	4.65	Yes	Yes	0	5	9
67	R:R:E196	R:R:I115	55.9784	6.83	Yes	No	0	5	8
68	R:R:R125	R:R:Y294	18.7157	5.14	No	Yes	0	9	9
69	R:R:I211	R:R:Y126	12.2333	2.42	No	Yes	0	8	7
70	R:R:I211	R:R:V129	11.1377	9.22	No	No	0	8	8
71	R:R:I139	R:R:S61	10.8647	6.19	No	No	0	7	6
72	R:R:F180	R:R:H189	12.5704	12.44	Yes	Yes	1	3	5
73	R:R:F240	R:R:L201	12.4187	3.65	Yes	Yes	0	9	7
74	R:R:I233	R:R:R125	15.5773	5.01	No	No	0	7	9
75	R:R:I212	R:R:I233	10.6287	2.94	No	No	0	5	7
76	R:R:L215	R:R:V129	10.0354	2.98	No	No	0	8	8
77	R:R:V293	R:R:Y294	13.9255	3.79	No	Yes	0	8	9
78	R:R:L83	R:R:Y284	20.0573	4.69	Yes	Yes	1	6	7
79	R:R:F244	R:R:I115	56.4335	8.79	Yes	No	0	8	8
80	R:R:F193	R:R:R251	31.0366	6.41	Yes	Yes	1	6	5
81	R:R:E196	R:R:F193	50.7163	7	Yes	Yes	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	19.41	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L104	14.56	1	Yes	No	0	5	0	1
L:L:?1	R:R:L107	21.84	1	Yes	No	0	6	0	1
L:L:?1	R:R:R111	10.65	1	Yes	No	0	8	0	1
L:L:?1	R:R:C177	4.17	1	Yes	No	0	9	0	1
L:L:?1	R:R:S179	3.95	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F180	10.68	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y284	9.25	1	Yes	Yes	0	7	0	1
R:R:L34	R:R:L83	4.15	1	No	Yes	8	6	2	1
R:R:L34	R:R:Y87	7.03	1	No	Yes	8	6	2	2
R:R:L76	R:R:Y284	5.86	0	No	Yes	7	7	2	1
R:R:L80	R:R:Y284	4.69	0	No	Yes	8	7	2	1
R:R:L83	R:R:Y87	15.24	1	Yes	Yes	6	6	1	2
R:R:L83	R:R:Y284	4.69	1	Yes	Yes	6	7	1	1
R:R:C100	R:R:W93	10.45	1	No	Yes	9	9	2	2
R:R:C177	R:R:W93	20.89	1	No	Yes	9	9	1	2
R:R:C100	R:R:C177	7.28	1	No	No	9	9	2	1
R:R:L104	R:R:S179	4.5	1	No	Yes	5	4	1	1
R:R:L107	R:R:Y284	4.69	1	No	Yes	6	7	1	1
R:R:E196	R:R:R111	8.14	0	Yes	No	5	8	2	1
R:R:R111	R:R:T283	7.76	0	No	Yes	8	8	1	2
R:R:F180	R:R:S179	3.96	1	Yes	Yes	3	4	1	1
R:R:H189	R:R:S179	4.18	1	Yes	Yes	5	4	2	1
R:R:F180	R:R:H189	12.44	1	Yes	Yes	3	5	1	2
R:R:E190	R:R:F180	5.83	1	No	Yes	4	3	2	1
R:R:F180	R:R:F193	11.79	1	Yes	Yes	3	6	1	2
R:R:F180	R:R:R251	9.62	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	9.65	1	Yes	Yes	3	4	1	2
R:R:E190	R:R:R251	13.96	1	No	Yes	4	5	2	2
R:R:E196	R:R:F193	7	0	Yes	Yes	5	6	2	2
R:R:F193	R:R:R251	6.41	1	Yes	Yes	6	5	2	2
R:R:F193	R:R:F276	4.29	1	Yes	Yes	6	4	2	2
R:R:F276	R:R:R251	16.03	1	Yes	Yes	4	5	2	2
R:R:L280	R:R:T283	5.9	1	No	Yes	5	8	2	2
R:R:L280	R:R:Y284	4.69	1	No	Yes	5	7	2	1
R:R:T283	R:R:Y284	7.49	1	Yes	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JKY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.79
Number of Linked Nodes	282
Number of Links	329
Number of Hubs	48
Number of Links mediated by Hubs	179
Number of Communities	13
Number of Nodes involved in Communities	70
Number of Links involved in Communities	91

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	70339
Length Of Smallest Path	3
Average Path Length	14.0428
Length of Longest Path	32
Minimum Path Strength	1.535
Average Path Strength	6.86752
Maximum Path Strength	20.625
Minimum Path Correlation	0.7
Average Path Correlation	0.919365
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	43.9656
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.8632
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • cellular process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • positive regulation of cell communication • regulation of localization • establishment of protein localization • system process • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • intracellular protein localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • cellular anatomical structure • cell junction • cell periphery • plasma membrane • membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • peptide secretion • negative regulation of protein localization • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P9X
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P9X
Name	(5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid
Synonyms	Acifran
Identifier
Formula	C12 H10 O4
Molecular Weight	218.205
SMILES
PubChem	76969700
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	27
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>9JKY_nogp_Chain_R D H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	9JKY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.72	2025-10-29	To be published
	9JKY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.72	2025-10-29	To be published
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9KT7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.73	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.73	2025-12-10	10.1021/acs.jmedchem.4c02567

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