psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F10	R:R:H9	3.39	No	No	0	7	6
2	R:R:F10	R:R:F21	16.08	No	No	5	7	2
3	R:R:F10	R:R:R270	6.41	No	No	5	7	1
4	R:R:L11	R:R:N17	5.49	No	No	0	8	5
5	R:R:D14	R:R:E12	5.2	No	No	0	5	5
6	R:R:E12	R:R:V20	9.98	No	No	0	5	2
7	R:R:E12	R:R:N171	10.52	No	No	0	5	1
8	R:R:I13	R:R:N17	5.66	No	No	0	3	5
9	R:R:D14	R:R:I169	7	No	No	0	5	1
10	R:R:K15	R:R:K16	4.31	No	No	0	3	4
11	R:R:C18	R:R:S181	3.44	No	No	6	9	4
12	R:R:C18	R:R:C183	7.28	No	No	6	9	1
13	R:R:C19	R:R:C266	7.28	No	No	0	4	7
14	R:R:C19	R:R:Y269	4.03	No	Yes	0	4	2
15	R:R:L176	R:R:V20	4.47	No	No	0	4	2
16	R:R:F21	R:R:R270	4.28	No	No	5	2	1
17	R:R:D273	R:R:F21	4.78	No	No	0	4	2
18	R:R:R22	R:R:R90	24.52	No	No	0	3	4
19	R:R:A174	R:R:R22	4.15	No	No	0	2	3
20	R:R:D23	R:R:F25	7.17	No	No	7	4	6
21	R:R:D23	R:R:L274	9.5	No	No	7	4	1
22	R:R:F25	R:R:L274	3.65	No	No	7	6	1
23	R:R:I26	R:R:L30	7.14	No	Yes	1	5	5
24	R:R:I26	R:R:Y87	3.63	No	Yes	1	5	6
25	R:R:L30	R:R:V29	2.98	Yes	No	0	5	5
26	R:R:I278	R:R:V29	3.07	No	No	0	6	5
27	R:R:L30	R:R:Y87	11.72	Yes	Yes	1	5	6
28	R:R:L30	R:R:S281	3	Yes	No	0	5	6
29	R:R:P31	R:R:P32	7.79	No	No	0	6	5
30	R:R:G35	R:R:M84	3.49	No	No	0	5	7
31	R:R:E37	R:R:S281	5.75	No	No	0	7	6
32	R:R:E37	R:R:Y284	3.37	No	Yes	0	7	7
33	R:R:E37	R:R:M285	5.41	No	No	0	7	5
34	R:R:F38	R:R:L80	3.65	No	No	0	7	8
35	R:R:F38	R:R:P81	5.78	No	No	0	7	8
36	R:R:F40	R:R:I39	5.02	No	No	0	6	5
37	R:R:F40	R:R:M288	4.98	No	No	0	6	8
38	R:R:G41	R:R:I77	5.29	No	No	0	8	6
39	R:R:G41	R:R:M288	3.49	No	No	0	8	8
40	R:R:F74	R:R:L42	3.65	Yes	No	0	7	7
41	R:R:F296	R:R:G44	3.01	Yes	No	0	8	7
42	R:R:D73	R:R:N45	6.73	Yes	No	0	9	9
43	R:R:N45	R:R:P291	4.89	No	No	0	9	9
44	R:R:F74	R:R:G46	3.01	Yes	No	0	7	4
45	R:R:L47	R:R:W50	6.83	No	No	0	6	4
46	R:R:I51	R:R:L47	4.28	No	No	0	7	6
47	R:R:F296	R:R:L47	3.65	Yes	No	0	8	6
48	R:R:A48	R:R:Y295	4	No	Yes	0	9	7
49	R:R:F67	R:R:L49	3.65	Yes	No	0	6	7
50	R:R:F74	R:R:L49	4.87	Yes	No	0	7	7
51	R:R:H55	R:R:W50	6.35	No	No	0	5	4
52	R:R:H55	R:R:I51	6.63	No	No	0	5	7
53	R:R:F301	R:R:I51	6.28	Yes	No	0	9	7
54	R:R:F52	R:R:F67	3.22	No	Yes	0	7	6
55	R:R:F52	R:R:Y295	11.35	No	Yes	2	7	7
56	R:R:F301	R:R:F52	4.29	Yes	No	2	9	7
57	R:R:L56	R:R:W59	3.42	No	No	0	5	6
58	R:R:L56	R:R:R63	3.64	No	No	0	5	7
59	R:R:I64	R:R:W59	3.52	No	No	0	7	6
60	R:R:F67	R:R:W59	11.02	Yes	No	0	6	6
61	R:R:I139	R:R:S61	4.64	No	No	0	7	6
62	R:R:R63	R:R:S300	3.95	No	No	0	7	5
63	R:R:I64	R:R:N141	4.25	No	No	0	7	2
64	R:R:A144	R:R:I64	6.5	No	No	0	7	7
65	R:R:F65	R:R:V120	9.18	No	No	0	7	7
66	R:R:L66	R:R:Y294	3.52	No	Yes	2	8	9
67	R:R:L66	R:R:Y295	5.86	No	Yes	2	8	7
68	R:R:F67	R:R:V71	7.87	Yes	No	0	6	6
69	R:R:F117	R:R:N68	14.5	No	No	8	8	9
70	R:R:N68	R:R:S148	7.45	No	No	0	9	8
71	R:R:N68	R:R:W152	5.65	No	Yes	8	9	9
72	R:R:L69	R:R:S114	3	Yes	No	0	9	9
73	R:R:L118	R:R:L69	4.15	No	Yes	2	9	9
74	R:R:D290	R:R:L69	4.07	Yes	Yes	0	9	9
75	R:R:L69	R:R:Y294	3.52	Yes	Yes	2	9	9
76	R:R:L69	R:R:Y295	3.52	Yes	Yes	2	9	7
77	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
78	R:R:D73	R:R:S114	4.42	Yes	No	0	9	9
79	R:R:D73	R:R:S287	11.78	Yes	No	0	9	8
80	R:R:D290	R:R:D73	10.65	Yes	Yes	0	9	9
81	R:R:L75	R:R:N110	6.87	No	No	0	6	9
82	R:R:L76	R:R:N110	5.49	No	No	0	7	9
83	R:R:I77	R:R:S287	4.64	No	No	0	6	8
84	R:R:C79	R:R:L107	3.17	No	Yes	0	6	6
85	R:R:L80	R:R:L83	4.15	No	No	0	8	6
86	R:R:L80	R:R:Y284	3.52	No	Yes	0	8	7
87	R:R:F82	R:R:F95	8.57	No	Yes	0	6	7
88	L:L:?1	R:R:L83	3.64	Yes	No	0	0	6
89	R:R:D85	R:R:R89	4.76	No	No	0	4	4
90	R:R:D85	R:R:F95	8.36	No	Yes	0	4	7
91	R:R:N86	R:R:W91	6.78	No	Yes	1	5	4
92	R:R:N86	R:R:W93	9.04	No	Yes	1	5	9
93	L:L:?1	R:R:N86	7.22	Yes	No	1	0	5
94	R:R:W91	R:R:Y87	5.79	Yes	Yes	1	4	6
95	L:L:?1	R:R:Y87	8.22	Yes	Yes	1	0	6
96	R:R:K94	R:R:R89	6.19	No	No	0	3	4
97	R:R:S178	R:R:W91	6.18	No	Yes	1	4	4
98	R:R:F277	R:R:W91	9.02	No	Yes	0	5	4
99	L:L:?1	R:R:W91	3.99	Yes	Yes	1	0	4
100	R:R:F95	R:R:W93	15.03	Yes	Yes	0	7	9
101	R:R:C100	R:R:W93	3.92	Yes	Yes	1	9	9
102	R:R:N175	R:R:W93	3.39	Yes	Yes	0	4	9
103	R:R:C177	R:R:W93	5.22	No	Yes	1	9	9
104	R:R:F95	R:R:K94	8.69	Yes	No	0	7	3
105	R:R:D97	R:R:P168	9.66	No	Yes	0	3	4
106	R:R:I98	R:R:P99	3.39	No	No	0	2	5
107	R:R:I98	R:R:R101	7.52	No	No	0	2	6
108	R:R:C100	R:R:L104	3.17	Yes	Yes	1	9	5
109	R:R:C100	R:R:M167	6.48	Yes	No	1	9	3
110	R:R:C100	R:R:P168	5.65	Yes	Yes	1	9	4
111	R:R:C100	R:R:C177	7.28	Yes	No	1	9	9
112	R:R:L104	R:R:M103	4.24	Yes	No	1	5	5
113	L:L:?1	R:R:M103	7.44	Yes	No	1	0	5
114	R:R:C177	R:R:L104	3.17	No	Yes	1	9	5
115	R:R:L104	R:R:S179	3	Yes	No	1	5	4
116	L:L:?1	R:R:L104	6.07	Yes	Yes	1	0	5
117	R:R:F105	R:R:M106	3.73	Yes	No	0	6	5
118	R:R:F105	R:R:T159	6.49	Yes	No	0	6	7
119	R:R:F105	R:R:L163	8.53	Yes	No	0	6	5
120	R:R:L107	R:R:Y284	5.86	Yes	Yes	1	6	7
121	L:L:?1	R:R:L107	7.28	Yes	Yes	1	0	6
122	R:R:M109	R:R:N110	7.01	Yes	No	0	5	9
123	R:R:M109	R:R:W152	4.65	Yes	Yes	0	5	9
124	R:R:M109	R:R:T155	4.52	Yes	Yes	0	5	7
125	R:R:M109	R:R:T159	7.53	Yes	No	0	5	7
126	R:R:F193	R:R:R111	7.48	Yes	Yes	1	6	8
127	R:R:E196	R:R:R111	10.47	No	Yes	1	5	8
128	R:R:F244	R:R:R111	4.28	Yes	Yes	1	8	8
129	R:R:R111	R:R:T283	3.88	Yes	No	1	8	8
130	L:L:?1	R:R:R111	8.52	Yes	Yes	1	0	8
131	R:R:I116	R:R:Q112	5.49	No	Yes	0	5	7
132	R:R:Q112	R:R:T155	5.67	Yes	Yes	0	7	7
133	R:R:L158	R:R:Q112	9.32	No	Yes	0	5	7
134	R:R:M192	R:R:Q112	6.8	No	Yes	0	5	7
135	R:R:E196	R:R:I115	5.47	No	No	0	5	8
136	R:R:I115	R:R:P200	3.39	No	No	0	8	9
137	R:R:F244	R:R:I115	8.79	Yes	No	0	8	8
138	R:R:I116	R:R:L151	5.71	No	No	0	5	7
139	R:R:F117	R:R:W152	10.02	No	Yes	8	8	9
140	R:R:L118	R:R:Y294	5.86	No	Yes	2	9	9
141	R:R:P200	R:R:T119	3.5	No	No	0	9	7
142	R:R:I203	R:R:T119	4.56	No	No	0	7	7
143	R:R:R125	R:R:V121	6.54	No	No	2	9	9
144	R:R:V121	R:R:Y294	3.79	No	Yes	2	9	9
145	R:R:D124	R:R:R128	11.91	No	No	0	8	8
146	R:R:R125	R:R:Y294	4.12	No	Yes	2	9	9
147	R:R:V130	R:R:Y126	11.36	Yes	Yes	3	8	7
148	R:R:H131	R:R:Y126	4.36	Yes	Yes	3	7	7
149	R:R:F206	R:R:Y126	3.09	No	Yes	3	4	7
150	R:R:C207	R:R:Y126	9.41	No	Yes	0	8	7
151	R:R:R210	R:R:Y126	7.2	Yes	Yes	3	4	7
152	R:R:F127	R:R:H131	4.53	Yes	Yes	3	5	7
153	R:R:F127	R:R:H134	3.39	Yes	Yes	3	5	4
154	R:R:F127	R:R:L136	7.31	Yes	No	3	5	4
155	R:R:N137	R:R:R128	6.03	No	No	0	4	8
156	R:R:V129	R:R:V130	3.21	No	Yes	0	8	8
157	R:R:I211	R:R:V129	12.29	No	No	0	8	8
158	R:R:L215	R:R:V129	2.98	No	No	0	8	8
159	R:R:H131	R:R:V130	5.54	Yes	Yes	3	7	8
160	R:R:R210	R:R:V130	3.92	Yes	Yes	3	4	8
161	R:R:S214	R:R:V130	6.46	No	Yes	0	5	8
162	R:R:H134	R:R:L136	3.86	Yes	No	3	4	4
163	R:R:I147	R:R:T143	3.04	No	No	0	5	3
164	R:R:G157	R:R:V160	3.68	No	No	0	5	4
165	R:R:H161	R:R:L162	6.43	No	No	0	7	4
166	R:R:H161	R:R:W188	7.41	No	No	0	7	5
167	R:R:K165	R:R:M167	7.2	No	No	0	4	3
168	R:R:M167	R:R:P168	5.03	No	Yes	1	3	4
169	R:R:N175	R:R:P168	6.52	Yes	Yes	0	4	4
170	R:R:G172	R:R:N171	5.09	No	No	0	3	1
171	R:R:L176	R:R:S178	3	No	No	0	4	4
172	L:L:?1	R:R:S178	6.58	Yes	No	1	0	4
173	R:R:H189	R:R:S179	6.97	No	No	0	5	4
174	L:L:?1	R:R:S179	3.95	Yes	No	1	0	4
175	R:R:F180	R:R:H189	11.31	Yes	No	0	3	5
176	R:R:F180	R:R:F193	12.86	Yes	Yes	0	3	6
177	R:R:F180	R:R:F276	10.72	Yes	Yes	0	3	4
178	L:L:?1	R:R:F180	11.75	Yes	Yes	0	0	3
179	R:R:C183	R:R:S181	5.16	No	No	6	1	4
180	R:R:I182	R:R:I254	7.36	Yes	No	0	3	4
181	R:R:I182	R:R:L258	4.28	Yes	No	4	3	3
182	R:R:I182	R:R:Y269	9.67	Yes	Yes	4	3	2
183	R:R:D273	R:R:I182	5.6	No	Yes	0	4	3
184	R:R:C183	R:R:Q187	6.1	No	No	0	1	2
185	R:R:Q187	R:R:T185	5.67	No	No	0	2	2
186	R:R:A191	R:R:F186	4.16	No	No	0	3	4
187	R:R:E190	R:R:Q187	8.92	No	No	0	4	2
188	R:R:M192	R:R:W188	5.82	No	No	0	5	5
189	R:R:E190	R:R:R251	12.79	No	Yes	10	4	5
190	R:R:E190	R:R:F255	12.83	No	No	10	4	5
191	R:R:E196	R:R:F193	3.5	No	Yes	1	5	6
192	R:R:F198	R:R:L194	3.65	No	No	0	5	4
193	R:R:F197	R:R:F198	5.36	Yes	No	0	8	5
194	R:R:F197	R:R:L201	8.53	Yes	Yes	1	8	7
195	R:R:F197	R:R:F240	4.29	Yes	Yes	1	8	9
196	R:R:F197	R:R:F244	4.29	Yes	Yes	1	8	8
197	R:R:F197	R:R:V248	7.87	Yes	No	0	8	8
198	R:R:F240	R:R:L201	3.65	Yes	Yes	1	9	7
199	R:R:F240	R:R:I204	3.77	Yes	No	0	9	8
200	R:R:F206	R:R:R210	4.28	No	Yes	3	4	4
201	R:R:I233	R:R:S208	3.1	No	No	0	7	8
202	R:R:R210	R:R:W213	8	Yes	No	0	4	3
203	R:R:I212	R:R:R216	6.26	Yes	No	0	5	4
204	R:R:Q217	R:R:W213	8.76	No	No	0	5	3
205	R:R:L215	R:R:M220	4.24	No	No	9	8	3
206	R:R:I226	R:R:L215	7.14	Yes	No	9	6	8
207	R:R:D221	R:R:R216	11.91	No	No	0	3	4
208	R:R:M220	R:R:R218	3.72	No	No	0	3	5
209	R:R:I226	R:R:M220	10.2	Yes	No	9	6	3
210	R:R:H223	R:R:K225	6.55	No	No	0	4	5
211	R:R:H223	R:R:I226	5.3	No	Yes	0	4	6
212	R:R:F232	R:R:R228	7.48	No	No	0	7	7
213	R:R:P299	R:R:R228	10.09	No	No	0	5	7
214	R:R:F232	R:R:S297	7.93	No	No	0	7	6
215	R:R:V235	R:R:V293	3.21	No	No	0	5	8
216	R:R:V236	R:R:Y294	8.83	No	Yes	0	8	9
217	R:R:N286	R:R:V239	2.96	Yes	No	0	9	7
218	R:R:F240	R:R:F244	3.22	Yes	Yes	1	9	8
219	R:R:L245	R:R:V241	2.98	Yes	No	0	6	5
220	R:R:C243	R:R:N286	11.02	No	Yes	0	8	9
221	R:R:F244	R:R:T283	10.38	Yes	No	1	8	8
222	R:R:F244	R:R:N286	6.04	Yes	Yes	0	8	9
223	R:R:L245	R:R:P246	3.28	Yes	No	0	6	9
224	R:R:L245	R:R:V249	2.98	Yes	No	0	6	6
225	R:R:P246	R:R:T279	3.5	No	No	0	9	7
226	R:R:I252	R:R:V248	3.07	No	No	0	6	8
227	R:R:I254	R:R:R251	7.52	No	Yes	0	4	5
228	R:R:F255	R:R:R251	10.69	No	Yes	10	5	5
229	R:R:F276	R:R:R251	7.48	Yes	Yes	0	4	5
230	R:R:R253	R:R:V272	6.54	No	Yes	0	5	4
231	R:R:I254	R:R:V272	6.14	No	Yes	0	4	4
232	R:R:T260	R:R:W256	7.28	No	No	0	1	4
233	R:R:L257	R:R:Y269	4.69	No	Yes	4	3	2
234	R:R:L257	R:R:V272	2.98	No	Yes	4	3	4
235	R:R:L258	R:R:Y269	8.21	No	Yes	4	3	2
236	R:R:S261	R:R:T260	3.2	No	No	0	3	1
237	R:R:N265	R:R:Q264	3.96	No	No	0	5	3
238	R:R:V268	R:R:Y269	7.57	No	Yes	0	1	2
239	R:R:V272	R:R:Y269	3.79	Yes	Yes	4	4	2
240	R:R:D273	R:R:F277	9.55	No	No	0	4	5
241	R:R:I278	R:R:L274	7.14	No	No	0	6	1
242	R:R:F276	R:R:F277	5.36	Yes	No	0	4	5
243	R:R:F276	R:R:L280	3.65	Yes	No	0	4	5
244	L:L:?1	R:R:L280	3.64	Yes	No	0	0	5
245	L:L:?1	R:R:Y284	7.19	Yes	Yes	1	0	7
246	R:R:L289	R:R:M285	5.65	No	No	0	7	5
247	R:R:D290	R:R:N286	4.04	Yes	Yes	0	9	9
248	R:R:D290	R:R:P291	6.44	Yes	No	0	9	9
249	R:R:F296	R:R:V292	5.24	Yes	No	0	8	6
250	R:R:Y294	R:R:Y295	3.97	Yes	Yes	2	9	7
251	R:R:F301	R:R:Y295	3.09	Yes	Yes	2	9	7
252	R:R:F296	R:R:F301	7.5	Yes	Yes	0	8	9
253	R:R:P299	R:R:S298	3.56	No	No	0	5	8
254	R:R:I211	R:R:I233	2.94	No	No	0	8	7
255	R:R:I212	R:R:I230	2.94	Yes	No	0	5	6
256	R:R:A108	R:R:H189	2.93	No	No	0	4	5
257	R:R:N17	R:R:T263	2.92	No	No	0	5	3
258	R:R:F282	R:R:P246	2.89	No	No	0	7	9
259	R:R:I98	R:R:L102	2.85	No	No	0	2	5
260	R:R:I147	R:R:L151	2.85	No	No	0	5	7
261	R:R:C53	R:R:F54	2.79	No	No	0	4	4
262	R:R:L30	R:R:L34	2.77	Yes	No	0	5	8
263	R:R:A144	R:R:F65	2.77	No	No	0	7	7
264	R:R:L107	R:R:L76	2.77	Yes	No	0	6	7
265	R:R:L195	R:R:L199	2.77	No	No	0	4	4
266	R:R:L201	R:R:L205	2.77	Yes	No	0	7	4
267	R:R:D92	R:R:N175	2.69	No	Yes	0	4	4
268	R:R:R128	R:R:S61	2.64	No	No	0	8	6
269	R:R:N175	R:R:Q170	2.64	Yes	No	0	4	1
270	R:R:F193	R:R:S247	2.64	Yes	No	0	6	6
271	R:R:R89	R:R:V88	2.62	No	No	0	4	3
272	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
273	R:R:F276	R:R:V250	2.62	Yes	No	0	4	5
274	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
275	R:R:A191	R:R:W188	2.59	No	No	0	3	5
276	R:R:H184	R:R:L258	2.57	No	No	0	3	3
277	R:R:H134	R:R:N137	2.55	Yes	No	0	4	4
278	R:R:F74	R:R:I78	2.51	Yes	No	0	7	6
279	R:R:F197	R:R:L245	2.44	Yes	Yes	0	8	6
280	R:R:Q219	R:R:R222	2.34	No	No	0	3	3
281	R:R:G172	R:R:G173	2.11	No	No	0	3	4
282	R:R:G96	R:R:P99	2.03	No	No	0	7	5
283	R:R:R22	R:R:W91	2	No	Yes	0	3	4
284	R:R:G113	R:R:T155	1.82	No	Yes	0	7	7
285	R:R:P31	R:R:V88	1.77	No	No	0	6	3
286	R:R:G44	R:R:L43	1.71	No	No	0	7	4
287	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
288	R:R:A275	R:R:V250	1.7	No	No	0	5	5
289	R:R:C19	R:R:T263	1.69	No	No	0	4	3
290	R:R:L199	R:R:P200	1.64	No	No	0	4	9
291	R:R:C207	R:R:I203	1.64	No	No	0	8	7
292	R:R:C243	R:R:I242	1.64	No	No	0	8	5
293	R:R:S298	R:R:S300	1.63	No	No	0	8	5
294	R:R:A122	R:R:I204	1.62	No	No	0	9	8
295	R:R:A237	R:R:I204	1.62	No	No	0	7	8
296	R:R:S271	R:R:V272	1.62	No	Yes	0	3	4
297	R:R:V27	R:R:V88	1.6	No	No	0	3	3
298	R:R:S140	R:R:T143	1.6	No	No	0	6	3
299	R:R:V235	R:R:V239	1.6	No	No	0	5	7
300	R:R:V236	R:R:V293	1.6	No	No	0	8	8
301	R:R:V292	R:R:V293	1.6	No	No	0	6	8
302	R:R:K60	R:R:S58	1.53	No	No	0	7	6
303	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
304	R:R:H133	R:R:P132	1.53	No	No	0	6	8
305	R:R:K28	R:R:V29	1.52	No	No	0	3	5
306	R:R:I146	R:R:T143	1.52	No	No	0	3	3
307	R:R:I156	R:R:T155	1.52	No	Yes	0	4	7
308	R:R:F38	R:R:G35	1.51	No	No	0	7	5
309	R:R:K16	R:R:T185	1.5	No	No	0	4	2
310	R:R:L34	R:R:V33	1.49	No	No	0	8	5
311	R:R:D124	R:R:S62	1.47	No	No	0	8	8
312	R:R:I212	R:R:I233	1.47	Yes	No	0	5	7
313	R:R:I226	R:R:I230	1.47	Yes	No	0	6	6
314	R:R:I238	R:R:I242	1.47	No	No	0	5	5
315	R:R:A135	R:R:H134	1.46	No	Yes	0	5	4
316	R:R:I212	R:R:M234	1.46	Yes	No	0	5	4
317	R:R:F95	R:R:P99	1.44	Yes	No	0	7	5
318	R:R:I154	R:R:L151	1.43	No	No	0	5	7
319	R:R:I154	R:R:L158	1.43	No	No	0	5	5
320	R:R:G153	R:R:W152	1.41	No	Yes	0	4	9
321	R:R:C53	R:R:F67	1.4	No	Yes	0	4	6
322	R:R:D221	R:R:K227	1.38	No	No	0	3	4
323	R:R:D23	R:R:D24	1.33	No	No	0	4	4
324	R:R:R142	R:R:S140	1.32	No	No	0	4	6
325	R:R:F105	R:R:V160	1.31	Yes	No	0	6	4
326	R:R:F232	R:R:T231	1.3	No	No	0	7	6
327	R:R:E267	R:R:R270	1.16	No	No	0	2	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L30	5.522	5	1	5
2	R:R:F67	5.432	5	0	6
3	R:R:L69	3.652	5	2	9
4	R:R:D73	8.395	4	0	9
5	R:R:F74	3.51	4	0	7
6	R:R:Y87	7.34	4	1	6
7	R:R:W91	5.62667	6	1	4
8	R:R:W93	7.32	5	1	9
9	R:R:F95	8.418	5	0	7
10	R:R:C100	5.3	5	1	9
11	R:R:L104	3.93	5	1	5
12	R:R:F105	5.015	4	0	6
13	R:R:L107	4.77	4	1	6
14	R:R:M109	5.9275	4	0	5
15	R:R:R111	6.926	5	1	8
16	R:R:Q112	6.82	4	0	7
17	R:R:Y126	7.084	5	3	7
18	R:R:F127	4.4625	4	3	5
19	R:R:V130	6.098	5	3	8
20	R:R:H131	3.99	4	3	7
21	R:R:H134	2.815	4	3	4
22	R:R:W152	4.864	5	8	9
23	R:R:T155	3.3825	4	0	7
24	R:R:P168	6.715	4	1	4
25	R:R:N175	3.81	4	0	4
26	R:R:F180	11.66	4	0	3
27	R:R:I182	6.7275	4	4	3
28	R:R:F193	6.62	4	1	6
29	R:R:F197	5.46333	6	1	8
30	R:R:L201	4.165	4	1	7
31	R:R:R210	5.85	4	3	4
32	R:R:I212	3.0325	4	0	5
33	R:R:I226	6.0275	4	9	6
34	R:R:F240	3.7325	4	1	9
35	R:R:F244	6.16667	6	1	8
36	R:R:L245	2.92	4	0	6
37	R:R:R251	9.62	4	10	5
38	R:R:Y269	6.32667	6	4	2
39	R:R:V272	4.214	5	4	4
40	R:R:F276	5.966	5	0	4
41	R:R:Y284	4.985	4	1	7
42	R:R:N286	6.015	4	0	9
43	R:R:D290	6.3	4	0	9
44	R:R:Y294	4.80143	7	2	9
45	R:R:Y295	5.11286	7	2	7
46	R:R:F296	4.85	4	0	8
47	R:R:F301	5.29	4	2	9
48	L:L:?1	6.57615	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D273	R:R:I182	16.3618	5.6	No	Yes	0	4	3
2	R:R:I182	R:R:Y269	13.4903	9.67	Yes	Yes	4	3	2
3	R:R:C19	R:R:Y269	10.6082	4.03	No	Yes	0	4	2
4	R:R:L176	R:R:V20	10.1011	4.47	No	No	0	4	2
5	R:R:L176	R:R:S178	11.5316	3	No	No	0	4	4
6	R:R:F277	R:R:W91	23.7837	9.02	No	Yes	0	5	4
7	R:R:D273	R:R:F277	23.336	9.55	No	No	0	4	5
8	R:R:I254	R:R:R251	14.8543	7.52	No	Yes	0	4	5
9	R:R:E190	R:R:R251	17.7049	12.79	No	Yes	10	4	5
10	R:R:E190	R:R:Q187	15.5713	8.92	No	No	0	4	2
11	R:R:F276	R:R:R251	35.081	7.48	Yes	Yes	0	4	5
12	R:R:L30	R:R:V29	10.2305	2.98	Yes	No	0	5	5
13	R:R:L30	R:R:Y87	15.323	11.72	Yes	Yes	1	5	6
14	R:R:N86	R:R:W93	31.1567	9.04	No	Yes	1	5	9
15	R:R:F95	R:R:W93	26.6447	15.03	Yes	Yes	0	7	9
16	R:R:R89	R:R:V88	11.4547	2.62	No	No	0	4	3
17	L:L:?1	R:R:W91	19.3173	3.99	Yes	Yes	1	0	4
18	L:L:?1	R:R:Y284	10.5628	7.19	Yes	Yes	1	0	7
19	L:L:?1	R:R:R111	100	8.52	Yes	Yes	1	0	8
20	R:R:F244	R:R:R111	85.9851	4.28	Yes	Yes	1	8	8
21	R:R:F244	R:R:N286	68.0354	6.04	Yes	Yes	0	8	9
22	R:R:D290	R:R:N286	56.3359	4.04	Yes	Yes	0	9	9
23	R:R:D290	R:R:D73	10.1046	10.65	Yes	Yes	0	9	9
24	R:R:D290	R:R:L69	46.7315	4.07	Yes	Yes	0	9	9
25	R:R:L69	R:R:Y295	40.4953	3.52	Yes	Yes	2	9	7
26	R:R:F52	R:R:Y295	26.0956	11.35	No	Yes	2	7	7
27	R:R:F52	R:R:F67	26.3265	3.22	No	Yes	0	7	6
28	R:R:F301	R:R:Y295	11.5316	3.09	Yes	Yes	2	9	7
29	R:R:F67	R:R:W59	16.743	11.02	Yes	No	0	6	6
30	R:R:L56	R:R:W59	10.3529	3.42	No	No	0	5	6
31	R:R:E196	R:R:R111	20.9751	10.47	No	Yes	1	5	8
32	R:R:E196	R:R:I115	29.7716	5.47	No	No	0	5	8
33	R:R:I115	R:R:P200	63.0408	3.39	No	No	0	8	9
34	R:R:P200	R:R:T119	59.0011	3.5	No	No	0	9	7
35	R:R:I203	R:R:T119	57.6405	4.56	No	No	0	7	7
36	R:R:C207	R:R:I203	56.273	1.64	No	No	0	8	7
37	R:R:C207	R:R:Y126	54.8984	9.41	No	Yes	0	8	7
38	R:R:H131	R:R:Y126	21.0556	4.36	Yes	Yes	3	7	7
39	R:R:F127	R:R:H131	17.3691	4.53	Yes	Yes	3	5	7
40	R:R:F127	R:R:H134	12.5984	3.39	Yes	Yes	3	5	4
41	R:R:F180	R:R:F276	28.1382	10.72	Yes	Yes	0	3	4
42	R:R:F180	R:R:F193	17.1977	12.86	Yes	Yes	0	3	6
43	R:R:F244	R:R:I115	35.2698	8.79	Yes	No	0	8	8
44	L:L:?1	R:R:L107	39.8867	7.28	Yes	Yes	1	0	6
45	R:R:L107	R:R:L76	39.2641	2.77	Yes	No	0	6	7
46	R:R:L76	R:R:N110	38.2498	5.49	No	No	0	7	9
47	R:R:M109	R:R:N110	36.2002	7.01	Yes	No	0	5	9
48	R:R:M109	R:R:T155	22.4651	4.52	Yes	Yes	0	5	7
49	R:R:Q112	R:R:T155	19.0654	5.67	Yes	Yes	0	7	7
50	R:R:V130	R:R:Y126	26.6517	11.36	Yes	Yes	3	8	7
51	R:R:V129	R:R:V130	24.8645	3.21	No	Yes	0	8	8
52	R:R:I211	R:R:V129	12.5844	12.29	No	No	0	8	8
53	R:R:L215	R:R:V129	10.8146	2.98	No	No	0	8	8
54	R:R:F197	R:R:F244	15.6658	4.29	Yes	Yes	1	8	8
55	R:R:I211	R:R:I233	11	2.94	No	No	0	8	7
56	R:R:I254	R:R:V272	10.6922	6.14	No	Yes	0	4	4
57	R:R:F276	R:R:L280	12.8817	3.65	Yes	No	0	4	5
58	L:L:?1	R:R:S178	10.1745	6.58	Yes	No	1	0	4
59	L:L:?1	R:R:F180	15.274	11.75	Yes	Yes	0	0	3
60	L:L:?1	R:R:L280	13.6896	3.64	Yes	No	0	0	5
61	L:L:?1	R:R:Y87	14.3017	8.22	Yes	Yes	1	0	6
62	L:L:?1	R:R:N86	25.7703	7.22	Yes	No	1	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I26	R:R:L30	7.14	1	No	Yes	5	5	2	2
R:R:I26	R:R:Y87	3.63	1	No	Yes	5	6	2	1
R:R:L30	R:R:Y87	11.72	1	Yes	Yes	5	6	2	1
R:R:E37	R:R:Y284	3.37	0	No	Yes	7	7	2	1
R:R:C79	R:R:L107	3.17	0	No	Yes	6	6	2	1
R:R:L80	R:R:L83	4.15	0	No	No	8	6	2	1
R:R:L80	R:R:Y284	3.52	0	No	Yes	8	7	2	1
L:L:?1	R:R:L83	3.64	1	Yes	No	0	6	0	1
R:R:N86	R:R:W91	6.78	1	No	Yes	5	4	1	1
R:R:N86	R:R:W93	9.04	1	No	Yes	5	9	1	2
L:L:?1	R:R:N86	7.22	1	Yes	No	0	5	0	1
R:R:W91	R:R:Y87	5.79	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:Y87	8.22	1	Yes	Yes	0	6	0	1
R:R:S178	R:R:W91	6.18	1	No	Yes	4	4	1	1
R:R:F277	R:R:W91	9.02	0	No	Yes	5	4	2	1
L:L:?1	R:R:W91	3.99	1	Yes	Yes	0	4	0	1
R:R:C100	R:R:W93	3.92	1	Yes	Yes	9	9	2	2
R:R:C177	R:R:W93	5.22	1	No	Yes	9	9	2	2
R:R:C100	R:R:L104	3.17	1	Yes	Yes	9	5	2	1
R:R:C100	R:R:C177	7.28	1	Yes	No	9	9	2	2
R:R:L104	R:R:M103	4.24	1	Yes	No	5	5	1	1
L:L:?1	R:R:M103	7.44	1	Yes	No	0	5	0	1
R:R:C177	R:R:L104	3.17	1	No	Yes	9	5	2	1
R:R:L104	R:R:S179	3	1	Yes	No	5	4	1	1
L:L:?1	R:R:L104	6.07	1	Yes	Yes	0	5	0	1
R:R:L107	R:R:Y284	5.86	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:L107	7.28	1	Yes	Yes	0	6	0	1
R:R:F193	R:R:R111	7.48	1	Yes	Yes	6	8	2	1
R:R:E196	R:R:R111	10.47	1	No	Yes	5	8	2	1
R:R:F244	R:R:R111	4.28	1	Yes	Yes	8	8	2	1
R:R:R111	R:R:T283	3.88	1	Yes	No	8	8	1	2
L:L:?1	R:R:R111	8.52	1	Yes	Yes	0	8	0	1
R:R:L176	R:R:S178	3	0	No	No	4	4	2	1
L:L:?1	R:R:S178	6.58	1	Yes	No	0	4	0	1
R:R:H189	R:R:S179	6.97	0	No	No	5	4	2	1
L:L:?1	R:R:S179	3.95	1	Yes	No	0	4	0	1
R:R:F180	R:R:H189	11.31	0	Yes	No	3	5	1	2
R:R:F180	R:R:F193	12.86	0	Yes	Yes	3	6	1	2
R:R:F180	R:R:F276	10.72	0	Yes	Yes	3	4	1	2
L:L:?1	R:R:F180	11.75	1	Yes	Yes	0	3	0	1
R:R:E196	R:R:F193	3.5	1	No	Yes	5	6	2	2
R:R:F244	R:R:T283	10.38	1	Yes	No	8	8	2	2
R:R:F276	R:R:F277	5.36	0	Yes	No	4	5	2	2
R:R:F276	R:R:L280	3.65	0	Yes	No	4	5	2	1
L:L:?1	R:R:L280	3.64	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	7.19	1	Yes	Yes	0	7	0	1
R:R:L107	R:R:L76	2.77	1	Yes	No	6	7	1	2
R:R:R22	R:R:W91	2	0	No	Yes	3	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KT8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.96
Number of Linked Nodes	281
Number of Links	327
Number of Hubs	48
Number of Links mediated by Hubs	180
Number of Communities	10
Number of Nodes involved in Communities	65
Number of Links involved in Communities	87

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	59300
Length Of Smallest Path	3
Average Path Length	12.897
Length of Longest Path	30
Minimum Path Strength	1.43
Average Path Strength	5.90138
Maximum Path Strength	14.335
Minimum Path Correlation	0.7
Average Path Correlation	0.922649
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	46.3665
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.0281
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • cellular process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • positive regulation of cell communication • regulation of localization • establishment of protein localization • system process • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • intracellular protein localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • cellular anatomical structure • cell junction • cell periphery • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • peptide secretion • negative regulation of protein localization • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P9X
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P9X
Name	(5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid
Synonyms	Acifran
Identifier
Formula	C12 H10 O4
Molecular Weight	218.205
SMILES
PubChem	76969700
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	27
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>9KT8_nogp_Chain_R H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	9JKY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.72	2025-10-29	To be published
	9JKY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.72	2025-10-29	To be published
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9KT7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.73	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.73	2025-12-10	10.1021/acs.jmedchem.4c02567

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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