psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F10	R:R:H9	27.15	No	No	0	7	6
2	R:R:F10	R:R:F21	11.79	No	Yes	0	7	2
3	R:R:E12	R:R:V20	5.7	No	No	0	5	2
4	R:R:E12	R:R:N171	5.26	No	Yes	0	5	1
5	R:R:D14	R:R:K15	6.91	No	No	0	5	3
6	R:R:C18	R:R:D14	6.22	No	No	6	9	5
7	R:R:C183	R:R:D14	3.11	No	No	6	1	5
8	R:R:K16	R:R:T185	3	No	No	0	4	2
9	R:R:C18	R:R:C183	7.28	No	No	6	9	1
10	R:R:C19	R:R:F21	4.19	No	Yes	5	4	2
11	R:R:C19	R:R:C266	5.46	No	No	5	4	7
12	R:R:S181	R:R:V20	4.85	No	No	0	4	2
13	R:R:C266	R:R:F21	6.98	No	Yes	5	7	2
14	R:R:F21	R:R:R270	8.55	Yes	No	0	2	1
15	R:R:D273	R:R:F21	7.17	No	Yes	0	4	2
16	R:R:R22	R:R:R90	10.66	Yes	No	0	3	4
17	R:R:R22	R:R:W91	5	Yes	Yes	1	3	4
18	R:R:D92	R:R:R22	3.57	No	Yes	0	4	3
19	R:R:N171	R:R:R22	4.82	Yes	Yes	1	1	3
20	R:R:A174	R:R:R22	6.91	No	Yes	1	2	3
21	R:R:D23	R:R:D24	5.32	No	No	3	4	4
22	R:R:D23	R:R:F25	8.36	No	No	3	4	6
23	R:R:D23	R:R:L274	6.79	No	No	3	4	1
24	R:R:D24	R:R:F25	3.58	No	No	3	4	6
25	R:R:F25	R:R:L274	6.09	No	No	3	6	1
26	R:R:I26	R:R:L30	4.28	No	Yes	0	5	5
27	R:R:I26	R:R:W91	4.7	No	Yes	0	5	4
28	R:R:L30	R:R:V29	2.98	Yes	No	0	5	5
29	R:R:L30	R:R:Y87	4.69	Yes	Yes	0	5	6
30	R:R:P31	R:R:P32	5.84	Yes	No	0	6	5
31	R:R:P31	R:R:V88	3.53	Yes	No	0	6	3
32	R:R:L34	R:R:S281	3	No	No	0	8	6
33	R:R:F40	R:R:L36	6.09	No	No	0	6	4
34	R:R:E37	R:R:S281	4.31	Yes	No	0	7	6
35	R:R:E37	R:R:Y284	7.86	Yes	No	0	7	7
36	R:R:E37	R:R:M285	5.41	Yes	No	7	7	5
37	R:R:E37	R:R:M288	4.06	Yes	No	7	7	8
38	R:R:F38	R:R:L42	3.65	No	No	0	7	7
39	R:R:F38	R:R:L80	9.74	No	No	0	7	8
40	R:R:F38	R:R:P81	10.11	No	No	0	7	8
41	R:R:D73	R:R:N45	5.39	Yes	No	0	9	9
42	R:R:N45	R:R:P291	4.89	No	No	0	9	9
43	R:R:F296	R:R:L47	7.31	No	No	0	8	6
44	R:R:A48	R:R:Y295	5.34	No	Yes	0	9	7
45	R:R:L49	R:R:V71	2.98	No	No	0	7	6
46	R:R:F74	R:R:L49	3.65	No	No	0	7	7
47	R:R:F54	R:R:W50	10.02	No	No	0	4	4
48	R:R:H55	R:R:W50	6.35	No	No	0	5	4
49	R:R:H55	R:R:I51	9.28	No	No	0	5	7
50	R:R:F52	R:R:Y295	9.28	No	Yes	0	7	7
51	R:R:C53	R:R:F54	9.78	No	No	0	4	4
52	R:R:F67	R:R:W59	12.03	No	No	0	6	6
53	R:R:F65	R:R:S61	5.28	No	No	0	7	6
54	R:R:I139	R:R:S61	6.19	No	No	0	7	6
55	R:R:A144	R:R:S61	3.42	No	No	0	7	6
56	R:R:D124	R:R:S62	5.89	No	No	8	8	8
57	R:R:R128	R:R:S62	3.95	No	No	8	8	8
58	R:R:L66	R:R:R63	3.64	No	No	0	8	7
59	R:R:R63	R:R:S298	5.27	No	No	0	7	8
60	R:R:I64	R:R:N141	4.25	No	No	0	7	2
61	R:R:A144	R:R:I64	4.87	No	No	0	7	7
62	R:R:F65	R:R:V120	7.87	No	No	0	7	7
63	R:R:L66	R:R:Y294	4.69	No	Yes	2	8	9
64	R:R:L66	R:R:Y295	8.21	No	Yes	2	8	7
65	R:R:F67	R:R:V71	7.87	No	No	0	6	6
66	R:R:F117	R:R:N68	9.67	No	No	9	8	9
67	R:R:N68	R:R:S148	10.43	No	No	0	9	8
68	R:R:N68	R:R:W152	7.91	No	No	9	9	9
69	R:R:L69	R:R:S114	3	Yes	No	0	9	9
70	R:R:L118	R:R:L69	4.15	No	Yes	0	9	9
71	R:R:D290	R:R:L69	4.07	Yes	Yes	0	9	9
72	R:R:L69	R:R:Y295	5.86	Yes	Yes	0	9	7
73	R:R:A70	R:R:Y295	5.34	No	Yes	0	8	7
74	R:R:D73	R:R:S114	5.89	Yes	No	0	9	9
75	R:R:D73	R:R:S287	11.78	Yes	No	0	9	8
76	R:R:D290	R:R:D73	9.31	Yes	Yes	0	9	9
77	R:R:F74	R:R:I78	3.77	No	No	0	7	6
78	R:R:L75	R:R:M106	4.24	No	No	0	6	5
79	R:R:L75	R:R:N110	8.24	No	No	0	6	9
80	R:R:L76	R:R:N110	6.87	No	No	0	7	9
81	R:R:L76	R:R:S287	3	No	No	0	7	8
82	R:R:C79	R:R:M103	3.24	No	No	0	6	5
83	R:R:C79	R:R:L107	3.17	No	No	0	6	6
84	R:R:F82	R:R:F95	6.43	No	No	0	6	7
85	R:R:L83	R:R:Y87	3.52	No	Yes	0	6	6
86	R:R:D85	R:R:F95	8.36	No	No	0	4	7
87	R:R:N86	R:R:Y87	3.49	No	Yes	1	5	6
88	R:R:N86	R:R:W91	9.04	No	Yes	1	5	4
89	R:R:N86	R:R:W93	5.65	No	Yes	1	5	9
90	R:R:W91	R:R:Y87	5.79	Yes	Yes	1	4	6
91	L:L:?1	R:R:Y87	3.04	Yes	Yes	1	0	6
92	R:R:S178	R:R:W91	7.41	No	Yes	0	4	4
93	R:R:F95	R:R:W93	13.03	No	Yes	0	7	9
94	R:R:C100	R:R:W93	9.14	No	Yes	1	9	9
95	R:R:P168	R:R:W93	4.05	Yes	Yes	1	4	9
96	R:R:C177	R:R:W93	11.75	No	Yes	1	9	9
97	R:R:D97	R:R:G96	3.35	No	No	0	3	7
98	R:R:G96	R:R:P99	4.06	No	No	0	7	5
99	R:R:D97	R:R:P168	8.05	No	Yes	0	3	4
100	R:R:I98	R:R:P99	3.39	No	No	0	2	5
101	R:R:I98	R:R:R101	3.76	No	No	0	2	6
102	R:R:C100	R:R:P168	7.53	No	Yes	1	9	4
103	R:R:C100	R:R:C177	7.28	No	No	1	9	9
104	R:R:M167	R:R:R101	6.2	No	No	0	3	6
105	R:R:K165	R:R:L104	4.23	No	No	0	4	5
106	L:L:?1	R:R:L104	4.48	Yes	No	0	0	5
107	R:R:F105	R:R:M106	3.73	Yes	No	0	6	5
108	R:R:F105	R:R:M109	6.22	Yes	Yes	10	6	5
109	R:R:F105	R:R:T159	6.49	Yes	No	10	6	7
110	R:R:F105	R:R:L163	12.18	Yes	No	0	6	5
111	L:L:?1	R:R:L107	7.17	Yes	No	0	0	6
112	L:L:?1	R:R:A108	4.08	Yes	No	0	0	4
113	R:R:M109	R:R:T155	3.01	Yes	No	0	5	7
114	R:R:I156	R:R:M109	2.92	No	Yes	0	4	5
115	R:R:M109	R:R:T159	4.52	Yes	No	10	5	7
116	R:R:R111	R:R:T283	6.47	No	No	0	8	8
117	L:L:?1	R:R:R111	7.08	Yes	No	0	0	8
118	R:R:Q112	R:R:T155	7.09	Yes	No	0	7	7
119	R:R:L158	R:R:Q112	7.99	No	Yes	1	5	7
120	R:R:E196	R:R:Q112	5.1	No	Yes	0	5	7
121	L:L:?1	R:R:Q112	7.76	Yes	Yes	1	0	7
122	R:R:G113	R:R:T155	3.64	No	No	0	7	7
123	R:R:E196	R:R:I115	5.47	No	No	0	5	8
124	R:R:I115	R:R:P200	3.39	No	No	0	8	9
125	R:R:F244	R:R:I115	6.28	No	No	0	8	8
126	R:R:I116	R:R:L151	5.71	No	No	0	5	7
127	R:R:F117	R:R:L151	3.65	No	No	0	8	7
128	R:R:F117	R:R:W152	11.02	No	No	9	8	9
129	R:R:L118	R:R:N286	4.12	No	Yes	0	9	9
130	R:R:L118	R:R:Y294	4.69	No	Yes	0	9	9
131	R:R:P200	R:R:T119	3.5	No	No	0	9	7
132	R:R:I203	R:R:T119	4.56	No	No	0	7	7
133	R:R:I204	R:R:T119	3.04	No	No	0	8	7
134	R:R:R125	R:R:V121	5.23	No	No	2	9	9
135	R:R:V121	R:R:Y294	6.31	No	Yes	2	9	9
136	R:R:D124	R:R:R128	11.91	No	No	8	8	8
137	R:R:R125	R:R:Y294	7.2	No	Yes	2	9	9
138	R:R:V130	R:R:Y126	11.36	Yes	Yes	4	8	7
139	R:R:H131	R:R:Y126	6.53	Yes	Yes	4	7	7
140	R:R:C207	R:R:Y126	9.41	No	Yes	0	8	7
141	R:R:R210	R:R:Y126	11.32	No	Yes	4	4	7
142	R:R:I211	R:R:Y126	3.63	No	Yes	0	8	7
143	R:R:F127	R:R:H131	5.66	Yes	Yes	0	5	7
144	R:R:F127	R:R:H134	7.92	Yes	No	0	5	4
145	R:R:F127	R:R:L136	8.53	Yes	No	0	5	4
146	R:R:N137	R:R:R128	7.23	No	No	0	4	8
147	R:R:I211	R:R:V129	9.22	No	No	0	8	8
148	R:R:L215	R:R:V129	4.47	No	No	0	8	8
149	R:R:H131	R:R:V130	11.07	Yes	Yes	4	7	8
150	R:R:R210	R:R:V130	3.92	No	Yes	4	4	8
151	R:R:S214	R:R:V130	3.23	No	Yes	0	5	8
152	R:R:H133	R:R:P132	3.05	No	No	0	6	8
153	R:R:I139	R:R:T143	6.08	No	No	0	7	3
154	R:R:I147	R:R:T143	3.04	No	No	0	5	3
155	R:R:G157	R:R:V160	3.68	No	No	0	5	4
156	L:L:?1	R:R:L158	5.38	Yes	No	1	0	5
157	R:R:H161	R:R:L162	10.29	No	No	1	7	4
158	R:R:H161	R:R:W188	14.81	No	No	1	7	5
159	L:L:?1	R:R:H161	8.33	Yes	No	1	0	7
160	L:L:?1	R:R:L162	11.65	Yes	No	1	0	4
161	R:R:I169	R:R:K165	2.91	No	No	0	1	4
162	R:R:M167	R:R:P168	5.03	No	Yes	0	3	4
163	R:R:A174	R:R:N171	4.69	No	Yes	1	2	1
164	R:R:L176	R:R:N171	9.61	No	Yes	0	4	1
165	L:L:?1	R:R:S178	3.89	Yes	No	0	0	4
166	L:L:?1	R:R:S179	5.83	Yes	No	0	0	4
167	R:R:F180	R:R:H189	4.53	Yes	Yes	1	3	5
168	R:R:F180	R:R:F193	6.43	Yes	No	0	3	6
169	R:R:F180	R:R:F276	7.5	Yes	Yes	0	3	4
170	L:L:?1	R:R:F180	14.99	Yes	Yes	1	0	3
171	R:R:I182	R:R:R251	3.76	Yes	Yes	0	3	5
172	R:R:I182	R:R:I254	7.36	Yes	No	0	3	4
173	R:R:I182	R:R:Y269	4.84	Yes	Yes	0	3	2
174	R:R:D273	R:R:I182	9.8	No	Yes	0	4	3
175	R:R:Q187	R:R:T185	8.5	No	No	0	2	2
176	R:R:H189	R:R:Q187	17.31	Yes	No	0	5	2
177	R:R:M192	R:R:W188	8.14	Yes	No	1	5	5
178	L:L:?1	R:R:W188	8.85	Yes	No	1	0	5
179	R:R:E190	R:R:H189	11.08	No	Yes	0	4	5
180	L:L:?1	R:R:H189	9.16	Yes	Yes	1	0	5
181	R:R:E190	R:R:R251	17.45	No	Yes	0	4	5
182	R:R:E190	R:R:F255	8.16	No	No	0	4	5
183	L:L:?1	R:R:M192	11.9	Yes	Yes	1	0	5
184	R:R:F193	R:R:R251	3.21	No	Yes	0	6	5
185	R:R:L194	R:R:V248	4.47	No	No	0	4	8
186	R:R:F197	R:R:F198	5.36	Yes	No	0	8	5
187	R:R:F197	R:R:L201	3.65	Yes	Yes	11	8	7
188	R:R:F197	R:R:F240	4.29	Yes	No	11	8	9
189	R:R:F197	R:R:F244	4.29	Yes	No	0	8	8
190	R:R:F197	R:R:L245	3.65	Yes	No	0	8	6
191	R:R:F197	R:R:V248	10.49	Yes	No	0	8	8
192	R:R:L199	R:R:P200	4.93	No	No	0	4	9
193	R:R:L201	R:R:L205	4.15	Yes	No	0	7	4
194	R:R:F240	R:R:L201	6.09	No	Yes	11	9	7
195	R:R:L201	R:R:V241	2.98	Yes	No	0	7	5
196	R:R:F206	R:R:R210	6.41	No	No	0	4	4
197	R:R:I233	R:R:S208	3.1	No	No	0	7	8
198	R:R:I211	R:R:I233	2.94	No	No	0	8	7
199	R:R:I212	R:R:R216	5.01	No	No	0	5	4
200	R:R:I212	R:R:I230	4.42	No	No	0	5	6
201	R:R:Q217	R:R:W213	4.38	No	No	0	5	3
202	R:R:L215	R:R:M220	4.24	No	No	0	8	3
203	R:R:D221	R:R:R216	7.15	No	No	0	3	4
204	R:R:Q217	R:R:R218	4.67	No	No	0	5	5
205	R:R:M220	R:R:R218	3.72	No	No	0	3	5
206	R:R:D221	R:R:R222	11.91	No	No	0	3	3
207	R:R:H223	R:R:K225	5.24	No	No	0	4	5
208	R:R:H223	R:R:I226	6.63	No	No	0	4	6
209	R:R:K225	R:R:R228	7.43	No	Yes	0	5	7
210	R:R:I226	R:R:I230	2.94	No	No	0	6	6
211	R:R:F232	R:R:R228	6.41	No	Yes	0	7	7
212	R:R:P299	R:R:R228	11.53	No	Yes	0	5	7
213	R:R:F232	R:R:S297	7.93	No	No	0	7	6
214	R:R:V236	R:R:Y294	8.83	No	Yes	0	8	9
215	R:R:C243	R:R:N286	3.15	No	Yes	0	8	9
216	R:R:F244	R:R:N286	7.25	No	Yes	0	8	9
217	R:R:L245	R:R:P246	3.28	No	No	0	6	9
218	R:R:L245	R:R:V249	2.98	No	No	0	6	6
219	R:R:P246	R:R:T279	3.5	No	Yes	0	9	7
220	R:R:S247	R:R:T279	3.2	No	Yes	0	6	7
221	R:R:I252	R:R:V248	3.07	No	No	0	6	8
222	R:R:F276	R:R:V250	3.93	Yes	No	0	4	5
223	R:R:T279	R:R:V250	4.76	Yes	No	0	7	5
224	R:R:F276	R:R:R251	16.03	Yes	Yes	0	4	5
225	R:R:R253	R:R:W256	6	No	No	0	5	4
226	R:R:I254	R:R:V272	6.14	No	No	0	4	4
227	R:R:T260	R:R:W256	7.28	No	No	0	1	4
228	R:R:L257	R:R:V268	2.98	No	No	0	3	1
229	R:R:L258	R:R:Y269	5.86	No	Yes	0	3	2
230	R:R:G262	R:R:S261	3.71	No	No	0	4	3
231	R:R:N265	R:R:Q264	3.96	No	No	0	5	3
232	R:R:C266	R:R:Y269	4.03	No	Yes	0	7	2
233	R:R:E267	R:R:R270	6.98	No	No	0	2	1
234	R:R:D273	R:R:F277	5.97	No	No	0	4	5
235	R:R:I278	R:R:L274	7.14	No	No	0	6	1
236	R:R:F276	R:R:L280	8.53	Yes	No	0	4	5
237	L:L:?1	R:R:L280	7.17	Yes	No	0	0	5
238	L:L:?1	R:R:Y284	5.31	Yes	No	0	0	7
239	R:R:M285	R:R:M288	4.33	No	No	7	5	8
240	R:R:D290	R:R:N286	4.04	Yes	Yes	0	9	9
241	R:R:D290	R:R:P291	6.44	Yes	No	0	9	9
242	R:R:F296	R:R:V292	3.93	No	No	0	8	6
243	R:R:V293	R:R:Y294	3.79	No	Yes	0	8	9
244	R:R:Y294	R:R:Y295	3.97	Yes	Yes	2	9	7
245	R:R:I51	R:R:L47	2.85	No	No	0	7	6
246	R:R:I77	R:R:L80	2.85	No	No	0	6	8
247	R:R:I154	R:R:L150	2.85	No	No	0	5	4
248	R:R:I230	R:R:L215	2.85	No	No	0	6	8
249	R:R:L195	R:R:M192	2.83	No	Yes	0	4	5
250	R:R:L289	R:R:M285	2.83	No	No	0	7	5
251	R:R:D92	R:R:K94	2.77	No	No	0	4	3
252	R:R:I116	R:R:Q112	2.74	No	Yes	0	5	7
253	R:R:N175	R:R:Q170	2.64	No	No	0	4	1
254	R:R:E267	R:R:N265	2.63	No	No	0	2	5
255	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
256	R:R:A72	R:R:W152	2.59	No	No	0	8	9
257	R:R:R228	R:R:T231	2.59	Yes	No	0	7	6
258	R:R:H184	R:R:L258	2.57	No	No	0	3	3
259	R:R:V268	R:R:Y269	2.52	No	Yes	0	1	2
260	R:R:F40	R:R:I39	2.51	No	No	0	6	5
261	R:R:I146	R:R:R142	2.51	No	No	0	3	4
262	R:R:F52	R:R:L56	2.44	No	No	0	7	5
263	R:R:F74	R:R:L75	2.44	No	No	0	7	6
264	R:R:D92	R:R:R89	2.38	No	No	0	4	4
265	R:R:G172	R:R:G173	2.11	No	No	0	3	4
266	R:R:G44	R:R:P291	2.03	No	No	0	7	9
267	R:R:P299	R:R:S298	1.78	No	No	0	5	8
268	R:R:P31	R:R:V27	1.77	Yes	No	0	6	3
269	R:R:G153	R:R:I156	1.76	No	No	0	4	4
270	R:R:G157	R:R:I156	1.76	No	No	0	5	4
271	R:R:G35	R:R:M84	1.75	No	No	0	5	7
272	R:R:G41	R:R:M288	1.75	No	No	0	8	8
273	R:R:G44	R:R:L43	1.71	No	No	0	7	4
274	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
275	R:R:A237	R:R:S208	1.71	No	No	0	7	8
276	R:R:C243	R:R:V239	1.71	No	No	0	8	7
277	R:R:A275	R:R:V250	1.7	No	No	0	5	5
278	R:R:C19	R:R:T263	1.69	No	No	0	4	3
279	R:R:L30	R:R:P31	1.64	Yes	Yes	0	5	6
280	R:R:S281	R:R:V33	1.62	No	No	0	6	5
281	R:R:A122	R:R:I204	1.62	No	No	0	9	8
282	R:R:A191	R:R:M192	1.61	No	Yes	0	3	5
283	R:R:S140	R:R:T143	1.6	No	No	0	6	3
284	R:R:V235	R:R:V239	1.6	No	No	0	5	7
285	R:R:V235	R:R:V293	1.6	No	No	0	5	8
286	R:R:V292	R:R:V293	1.6	No	No	0	6	8
287	R:R:I77	R:R:S287	1.55	No	No	0	6	8
288	R:R:I116	R:R:V120	1.54	No	No	0	5	7
289	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
290	R:R:K28	R:R:V29	1.52	No	No	0	3	5
291	R:R:M84	R:R:V88	1.52	No	No	0	7	3
292	R:R:F40	R:R:G41	1.51	No	No	0	6	8
293	R:R:I238	R:R:I242	1.47	No	No	0	5	5
294	R:R:D24	R:R:V27	1.46	No	No	0	4	3
295	R:R:I212	R:R:M234	1.46	No	No	0	5	4
296	R:R:G262	R:R:Y269	1.45	No	Yes	0	4	2
297	R:R:K15	R:R:K166	1.44	No	No	0	3	4
298	R:R:K166	R:R:M167	1.44	No	No	0	4	3
299	R:R:I13	R:R:L11	1.43	No	No	0	3	8
300	R:R:I154	R:R:L158	1.43	No	No	0	5	5
301	R:R:D221	R:R:K227	1.38	No	No	0	3	4
302	R:R:H259	R:R:T260	1.37	No	No	0	1	1
303	R:R:R142	R:R:S140	1.32	No	No	0	4	6
304	R:R:F282	R:R:T279	1.3	No	Yes	0	7	7
305	R:R:H134	R:R:N137	1.28	No	No	0	4	4
306	R:R:Q219	R:R:R222	1.17	No	No	0	3	3
307	R:R:N175	R:R:W93	1.13	No	Yes	0	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F21	7.736	5	5	2
2	R:R:R22	6.192	5	1	3
3	R:R:L30	3.3975	4	0	5
4	R:R:P31	3.195	4	0	6
5	R:R:E37	5.41	4	7	7
6	R:R:L69	4.27	4	0	9
7	R:R:D73	8.0925	4	0	9
8	R:R:Y87	4.106	5	1	6
9	R:R:W91	6.388	5	1	4
10	R:R:W93	7.45833	6	1	9
11	R:R:F105	7.155	4	10	6
12	R:R:M109	4.1675	4	10	5
13	R:R:Q112	6.136	5	1	7
14	R:R:Y126	8.45	5	4	7
15	R:R:F127	6.1825	4	0	5
16	R:R:V130	7.395	4	4	8
17	R:R:H131	6.1975	4	4	7
18	R:R:P168	6.165	4	1	4
19	R:R:N171	6.095	4	1	1
20	R:R:F180	8.3625	4	1	3
21	R:R:I182	6.44	4	0	3
22	R:R:H189	10.52	4	1	5
23	R:R:M192	6.12	4	1	5
24	R:R:F197	5.28833	6	11	8
25	R:R:L201	3.716	5	11	7
26	R:R:R228	6.99	4	0	7
27	R:R:R251	10.1125	4	0	5
28	R:R:Y269	3.74	5	0	2
29	R:R:F276	8.9975	4	0	4
30	R:R:T279	3.19	4	0	7
31	R:R:N286	4.64	4	0	9
32	R:R:D290	5.965	4	0	9
33	R:R:Y294	5.64	7	2	9
34	R:R:Y295	6.33333	6	2	7
35	L:L:?1	7.41588	17	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N171	R:R:R22	11.0442	4.82	Yes	Yes	1	1	3
2	R:R:R22	R:R:W91	24.1267	5	Yes	Yes	1	3	4
3	R:R:W91	R:R:Y87	13.8084	5.79	Yes	Yes	1	4	6
4	L:L:?1	R:R:Y87	53.0685	3.04	Yes	Yes	1	0	6
5	L:L:?1	R:R:F180	43.8883	14.99	Yes	Yes	1	0	3
6	R:R:F180	R:R:F193	20.0596	6.43	Yes	No	0	3	6
7	R:R:F193	R:R:R251	19.3115	3.21	No	Yes	0	6	5
8	R:R:I182	R:R:R251	83.3608	3.76	Yes	Yes	0	3	5
9	R:R:D273	R:R:I182	38.2077	9.8	No	Yes	0	4	3
10	R:R:D273	R:R:F21	31.5127	7.17	No	Yes	0	4	2
11	R:R:S178	R:R:W91	13.0444	7.41	No	Yes	0	4	4
12	L:L:?1	R:R:S178	13.7672	3.89	Yes	No	0	0	4
13	R:R:F180	R:R:F276	23.5402	7.5	Yes	Yes	0	3	4
14	R:R:F276	R:R:R251	48.1075	16.03	Yes	Yes	0	4	5
15	L:L:?1	R:R:L280	24.0823	7.17	Yes	No	0	0	5
16	R:R:F276	R:R:L280	23.4515	8.53	Yes	No	0	4	5
17	L:L:?1	R:R:H189	23.6924	9.16	Yes	Yes	1	0	5
18	R:R:E190	R:R:H189	20.8965	11.08	No	Yes	0	4	5
19	R:R:E190	R:R:R251	19.5999	17.45	No	Yes	0	4	5
20	R:R:P168	R:R:W93	13.4565	4.05	Yes	Yes	1	4	9
21	R:R:N86	R:R:W93	22.0662	5.65	No	Yes	1	5	9
22	R:R:N86	R:R:Y87	22.1803	3.49	No	Yes	1	5	6
23	R:R:F21	R:R:R270	14.2744	8.55	Yes	No	0	2	1
24	R:R:L30	R:R:P31	15.2856	1.64	Yes	Yes	0	5	6
25	R:R:L30	R:R:Y87	18.9628	4.69	Yes	Yes	0	5	6
26	L:L:?1	R:R:Y284	14.1476	5.31	Yes	No	0	0	7
27	R:R:E37	R:R:Y284	13.0032	7.86	Yes	No	0	7	7
28	L:L:?1	R:R:Q112	100	7.76	Yes	Yes	1	0	7
29	R:R:E196	R:R:Q112	84.7524	5.1	No	Yes	0	5	7
30	R:R:E196	R:R:I115	84.3181	5.47	No	No	0	5	8
31	R:R:F244	R:R:I115	81.3225	6.28	No	No	0	8	8
32	R:R:F244	R:R:N286	88.978	7.25	No	Yes	0	8	9
33	R:R:D290	R:R:N286	20.7919	4.04	Yes	Yes	0	9	9
34	R:R:D290	R:R:D73	14.6897	9.31	Yes	Yes	0	9	9
35	R:R:D73	R:R:S287	16.0527	11.78	Yes	No	0	9	8
36	R:R:F276	R:R:V250	16.4807	3.93	Yes	No	0	4	5
37	R:R:T279	R:R:V250	15.1747	4.76	Yes	No	0	7	5
38	R:R:P246	R:R:T279	13.3393	3.5	No	Yes	0	9	7
39	R:R:L245	R:R:P246	12.8859	3.28	No	No	0	6	9
40	R:R:F197	R:R:L245	13.0191	3.65	Yes	No	0	8	6
41	R:R:F197	R:R:F244	19.8028	4.29	Yes	No	0	8	8
42	R:R:L118	R:R:N286	67.2922	4.12	No	Yes	0	9	9
43	R:R:L118	R:R:Y294	61.9001	4.69	No	Yes	0	9	9
44	R:R:V293	R:R:Y294	13.4153	3.79	No	Yes	0	8	9
45	R:R:V292	R:R:V293	11.7384	1.6	No	No	0	6	8
46	R:R:F296	R:R:V292	10.2929	3.93	No	No	0	8	6
47	R:R:L69	R:R:Y295	18.2844	5.86	Yes	Yes	0	9	7
48	R:R:D290	R:R:L69	12.4041	4.07	Yes	Yes	0	9	9
49	R:R:Q112	R:R:T155	18.6997	7.09	Yes	No	0	7	7
50	R:R:M109	R:R:T155	16.6012	3.01	Yes	No	0	5	7
51	R:R:F105	R:R:M109	10.258	6.22	Yes	Yes	10	6	5
52	R:R:I116	R:R:Q112	21.5653	2.74	No	Yes	0	5	7
53	R:R:I116	R:R:V120	13.9257	1.54	No	No	0	5	7
54	R:R:F65	R:R:V120	12.7908	7.87	No	No	0	7	7
55	R:R:F65	R:R:S61	11.7574	5.28	No	No	0	7	6
56	R:R:F127	R:R:H131	10.1915	5.66	Yes	Yes	0	5	7
57	R:R:H131	R:R:Y126	13.783	6.53	Yes	Yes	4	7	7
58	R:R:I211	R:R:Y126	21.0993	3.63	No	Yes	0	8	7
59	R:R:I211	R:R:V129	25.8004	9.22	No	No	0	8	8
60	R:R:L215	R:R:V129	26.837	4.47	No	No	0	8	8
61	R:R:I230	R:R:L215	32.4257	2.85	No	No	0	6	8
62	R:R:I226	R:R:I230	41.0385	2.94	No	No	0	6	6
63	R:R:H223	R:R:I226	42.1099	6.63	No	No	0	4	6
64	R:R:H223	R:R:K225	43.175	5.24	No	No	0	4	5
65	R:R:K225	R:R:R228	44.2338	7.43	No	Yes	0	5	7
66	R:R:P299	R:R:R228	48.2977	11.53	No	Yes	0	5	7
67	R:R:P299	R:R:S298	49.3438	1.78	No	No	0	5	8
68	R:R:R63	R:R:S298	50.3582	5.27	No	No	0	7	8
69	R:R:L66	R:R:R63	51.3916	3.64	No	No	0	8	7
70	R:R:L66	R:R:Y294	44.7569	4.69	No	Yes	2	8	9
71	R:R:C266	R:R:Y269	10.7843	4.03	No	Yes	0	7	2
72	R:R:E267	R:R:R270	10.7145	6.98	No	No	0	2	1
73	R:R:I182	R:R:Y269	35.2596	4.84	Yes	Yes	0	3	2

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L30	R:R:Y87	4.69	0	Yes	Yes	5	6	2	1
R:R:E37	R:R:Y284	7.86	7	Yes	No	7	7	2	1
R:R:C79	R:R:L107	3.17	0	No	No	6	6	2	1
R:R:L83	R:R:Y87	3.52	0	No	Yes	6	6	2	1
R:R:N86	R:R:Y87	3.49	1	No	Yes	5	6	2	1
R:R:N86	R:R:W91	9.04	1	No	Yes	5	4	2	2
R:R:W91	R:R:Y87	5.79	1	Yes	Yes	4	6	2	1
L:L:?1	R:R:Y87	3.04	1	Yes	Yes	0	6	0	1
R:R:S178	R:R:W91	7.41	0	No	Yes	4	4	1	2
R:R:K165	R:R:L104	4.23	0	No	No	4	5	2	1
L:L:?1	R:R:L104	4.48	1	Yes	No	0	5	0	1
L:L:?1	R:R:L107	7.17	1	Yes	No	0	6	0	1
L:L:?1	R:R:A108	4.08	1	Yes	No	0	4	0	1
R:R:R111	R:R:T283	6.47	0	No	No	8	8	1	2
L:L:?1	R:R:R111	7.08	1	Yes	No	0	8	0	1
R:R:Q112	R:R:T155	7.09	1	Yes	No	7	7	1	2
R:R:L158	R:R:Q112	7.99	1	No	Yes	5	7	1	1
R:R:E196	R:R:Q112	5.1	0	No	Yes	5	7	2	1
L:L:?1	R:R:Q112	7.76	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L158	5.38	1	Yes	No	0	5	0	1
R:R:H161	R:R:L162	10.29	1	No	No	7	4	1	1
R:R:H161	R:R:W188	14.81	1	No	No	7	5	1	1
L:L:?1	R:R:H161	8.33	1	Yes	No	0	7	0	1
L:L:?1	R:R:L162	11.65	1	Yes	No	0	4	0	1
L:L:?1	R:R:S178	3.89	1	Yes	No	0	4	0	1
L:L:?1	R:R:S179	5.83	1	Yes	No	0	4	0	1
R:R:F180	R:R:H189	4.53	1	Yes	Yes	3	5	1	1
R:R:F180	R:R:F193	6.43	1	Yes	No	3	6	1	2
R:R:F180	R:R:F276	7.5	1	Yes	Yes	3	4	1	2
L:L:?1	R:R:F180	14.99	1	Yes	Yes	0	3	0	1
R:R:H189	R:R:Q187	17.31	1	Yes	No	5	2	1	2
R:R:M192	R:R:W188	8.14	1	Yes	No	5	5	1	1
L:L:?1	R:R:W188	8.85	1	Yes	No	0	5	0	1
R:R:E190	R:R:H189	11.08	0	No	Yes	4	5	2	1
L:L:?1	R:R:H189	9.16	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M192	11.9	1	Yes	Yes	0	5	0	1
R:R:F276	R:R:L280	8.53	0	Yes	No	4	5	2	1
L:L:?1	R:R:L280	7.17	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	5.31	1	Yes	No	0	7	0	1
R:R:L195	R:R:M192	2.83	0	No	Yes	4	5	2	1
R:R:I116	R:R:Q112	2.74	0	No	Yes	5	7	2	1
R:R:A191	R:R:M192	1.61	0	No	Yes	3	5	2	1
R:R:I154	R:R:L158	1.43	0	No	No	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KT7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.91
Number of Linked Nodes	276
Number of Links	307
Number of Hubs	35
Number of Links mediated by Hubs	143
Number of Communities	11
Number of Nodes involved in Communities	53
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	66100
Length Of Smallest Path	3
Average Path Length	14.5139
Length of Longest Path	37
Minimum Path Strength	1.44
Average Path Strength	5.89179
Maximum Path Strength	19.47
Minimum Path Correlation	0.7
Average Path Correlation	0.919315
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	45.2899
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.696
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FI7
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FI7
Name	2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid
Synonyms
Identifier
Formula	C19 H22 N4 O5
Molecular Weight	386.402
SMILES
PubChem	135416394
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	0
Total Bonds	52
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>9KT7_nogp_Chain_R H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	9JKY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.72	2025-10-29	To be published
	9JKY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.72	2025-10-29	To be published
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9KT7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.73	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.73	2025-12-10	10.1021/acs.jmedchem.4c02567

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