Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.8754165
2A:A:K46 5.1865229
3A:A:I184 6.025419
4A:A:F191 9.15254245
5A:A:F196 8.5165167
6A:A:M198 4.335407
7A:A:F199 7.8875415
8A:A:V201 6.3725419
9A:A:Q204 5.852519
10A:A:K210 5.64667619
11A:A:W211 5.54619
12A:A:H213 6.9775418
13A:A:F215 7.08571719
14A:A:I221 6.2275418
15A:A:Y230 7.06667638
16A:A:F250 6.828509
17A:A:C254 4.7954175
18A:A:W258 7.36714715
19A:A:F259 5.606519
20A:A:I265 3.8225408
21A:A:F267 4.015409
22A:A:F274 5.4075409
23A:A:K277 7.5439
24A:A:L283 6.6375437
25A:A:Y287 6.54837
26A:A:Y290 8.252537
27A:A:Y302 12.62436
28A:A:N311 6.794178
29A:A:K317 5.794177
30A:A:Y320 4.3845137
31A:A:T324 5.40254239
32A:A:T327 4.3408
33A:A:N331 4.415408
34A:A:F336 7.005408
35A:A:F354 11.095405
36B:B:I37 4.22572
37B:B:V40 5.365473
38B:B:H54 10.4925189
39B:B:Y59 9.844518
40B:B:W63 6.45333607
41B:B:D76 3.234509
42B:B:K78 5.7775408
43B:B:W82 12.0285189
44B:B:Y85 13.84754104
45B:B:N88 4.855407
46B:B:K89 7.602509
47B:B:H91 5.6025495
48B:B:W99 8.16286719
49B:B:Y105 4.235606
50B:B:N110 7.2375414
51B:B:Y111 6.356514
52B:B:L117 4.865419
53B:B:Y124 5.43833696
54B:B:V133 5.4075494
55B:B:H142 7.354519
56B:B:Y145 5.8725818
57B:B:F151 5.22619
58B:B:L152 3.6325403
59B:B:T159 3.994519
60B:B:D163 9.5275419
61B:B:W169 11.31518
62B:B:F180 8.018567
63B:B:H183 8.26833669
64B:B:D186 6.97419
65B:B:D205 5.992569
66B:B:K209 10.8125466
67B:B:W211 8.68333668
68B:B:Q220 6.425457
69B:B:F222 7.14558
70B:B:H225 10.96509
71B:B:D228 7.42419
72B:B:I232 5.4775458
73B:B:F235 6.646146
74B:B:P236 6.034147
75B:B:F241 7.252556
76B:B:R251 9.712558
77B:B:F253 7.648556
78B:B:D254 4.565409
79B:B:R256 6.63254279
80B:B:D258 7.71557
81B:B:Y264 7.14333605
82B:B:F278 7.58754147
83B:B:R283 7.85833679
84B:B:Y289 8.496207
85B:B:N295 7.56254206
86B:B:W297 7.40254208
87B:B:L300 7.1975476
88B:B:H311 7.585119
89B:B:M325 5.18405
90B:B:W332 12.71719
91B:B:D333 6.9254119
92B:B:K337 7.59254116
93B:B:W339 8.5945119
94G:G:V16 2.27407
95G:G:R27 6.425458
96G:G:Y40 8.1754146
97G:G:D48 7.3175409
98G:G:P49 3.3425407
99G:G:L51 4.376576
100G:G:N59 5.684109
101G:G:F61 4.778577108
102R:R:F71 8.07588
103R:R:H76 9.935489
104R:R:L78 5.698548
105R:R:M82 4.7275449
106R:R:S85 3.9254288
107R:R:D86 7.295449
108R:R:M94 4.8675407
109R:R:W107 12.488528
110R:R:Q115 6.95754296
111R:R:W117 6.6525425
112R:R:W130 7.2185216
113R:R:I135 5.8875449
114R:R:Y140 6.882508
115R:R:W141 9.72404
116R:R:I143 5.1925409
117R:R:Y149 10.73448
118R:R:R154 8.02833648
119R:R:W166 5.32254289
120R:R:S173 3.4875408
121R:R:Y185 13.89754154
122R:R:C192 9.495429
123R:R:E197 6.6275406
124R:R:F209 13.7125428
125R:R:P212 7.46754219
126R:R:Y220 5.76409
127R:R:M286 3.545408
128R:R:W298 8.64143728
129R:R:F301 8.0525427
130R:R:I315 5.48754124
131R:R:W319 5.4654124
132R:R:F323 5.485405
133R:R:W325 7.0425426
134R:R:Y328 8.215627
135R:R:F332 3.615406
136R:R:N334 6.235449
137R:R:Y338 6.3775449
138R:R:T339 7.2275407
139R:R:Y345 9.92688
140L:L:?1 9.63444920
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:S16 B:B:N88 65.24758.94NoYes077
2A:A:S16 B:B:K89 65.10326.12NoYes079
3B:B:K89 B:B:W82 64.374611.6YesYes099
4B:B:H54 B:B:W82 63.05546.35YesYes1899
5B:B:H54 B:B:S74 63.032613.95YesNo099
6B:B:D76 B:B:S74 62.88114.42YesNo099
7B:B:D76 B:B:K78 62.11634.15YesYes098
8B:B:K78 B:B:P94 61.65165.02YesNo085
9B:B:I93 B:B:P94 61.49573.39NoNo075
10B:B:I93 B:B:V133 57.54749.22NoYes974
11B:B:N88 B:B:T86 66.52424.39YesNo076
12B:B:D83 B:B:T86 66.663610.12NoNo086
13B:B:D83 B:B:R68 66.802614.29NoNo085
14B:B:R68 B:B:Y85 66.94128.81NoYes054
15B:B:S84 B:B:Y85 55.03665.09NoYes1054
16B:B:S84 B:B:W63 68.90094.94NoYes057
17B:B:L70 B:B:W63 95.853610.25NoYes057
18B:B:L70 B:B:M61 95.89255.65NoNo056
19B:B:C317 B:B:M61 95.93094.86NoNo076
20B:B:C317 B:B:S316 95.96893.44NoNo079
21B:B:S316 B:B:W332 96.00634.94NoYes099
22B:B:W332 B:B:Y59 95.047614.47YesYes198
23B:B:Q75 B:B:Y59 95.40615.78NoYes198
24B:B:Q75 B:B:W99 95.76227.67NoYes199
25A:A:F215 B:B:W99 81.0399.02YesYes199
26A:A:F215 A:A:W211 91.21494.01YesYes199
27A:A:R208 A:A:W211 1005NoYes099
28A:A:L249 A:A:R208 99.85284.86NoNo099
29A:A:F223 A:A:L249 99.78016.09NoNo099
30A:A:F223 A:A:F250 99.704912.86NoYes099
31A:A:F250 A:A:F307 97.83136.43YesNo098
32A:A:F307 A:A:L266 97.23423.65NoNo089
33A:A:L266 A:A:L268 97.63494.15NoNo098
34A:A:L227 A:A:L268 97.36448.3NoNo078
35A:A:F274 A:A:L227 97.273310.96YesNo097
36A:A:F274 A:A:Y230 96.90414.13YesYes098
37A:A:K277 A:A:Y230 91.93145.97YesYes398
38A:A:K277 A:A:S228 92.11464.59YesNo399
39A:A:K270 A:A:S228 92.10184.59NoNo099
40A:A:G45 A:A:K270 91.9863.49NoNo099
41A:A:G45 A:A:N269 91.86985.09NoNo099
42A:A:I49 A:A:N269 15.517.08NoNo2379
43A:A:C224 A:A:I49 21.21233.27NoNo077
44A:A:C224 A:A:S44 20.92593.44NoNo079
45A:A:K46 A:A:S44 20.35174.59YesNo099
46A:A:M198 A:A:M53 17.07844.33YesNo078
47A:A:F189 A:A:M53 16.4759.95NoNo098
48A:A:F189 A:A:F196 15.871116.08NoYes097
49A:A:F259 A:A:W258 10.52144.01YesYes195
50A:A:F259 A:A:I221 10.04328.79YesYes198
51A:A:I221 A:A:L37 10.48547.14YesNo189
52A:A:N269 A:A:T324 76.24288.77NoYes2399
53B:B:L117 B:B:W99 12.8084.56YesYes199
54B:B:L117 B:B:Y145 12.32543.52YesYes198
55A:A:F267 A:A:I265 79.81245.02YesYes098
56A:A:F267 A:A:T324 79.41873.89YesYes099
57B:B:R314 B:B:W332 19.792525.99NoYes189
58A:A:A338 A:A:I265 80.5033.25NoYes068
59A:A:A338 A:A:Y320 80.33364NoYes067
60A:A:K345 A:A:Y320 79.40233.58NoYes1357
61A:A:F354 A:A:K345 79.30716.2YesNo055
62A:A:F354 A:A:L348 78.087414.61YesNo059
63A:A:L348 R:R:I143 77.73469.99NoYes099
64R:R:I223 R:R:Y140 10.3673.63NoYes098
65R:R:I143 R:R:I223 10.66215.89YesNo099
66A:A:C351 R:R:I143 67.37383.27NoYes049
67A:A:C351 R:R:R139 67.190911.14NoNo049
68B:B:L126 B:B:V133 57.65454.47NoYes054
69B:B:L126 B:B:Y105 57.50253.52NoYes056
70B:B:H62 B:B:Y105 56.31163.27NoYes066
71B:B:H62 B:B:R150 56.139511.28NoNo066
72B:B:C148 B:B:R150 52.97186.96NoNo066
73B:B:C148 B:B:L190 52.79379.52NoNo065
74B:B:L190 B:B:S160 52.61639.01NoNo056
75B:B:S160 B:B:V187 52.26214.85NoNo069
76B:B:H183 B:B:V187 50.91844.15YesNo099
77B:B:H183 B:B:K209 24.641219.65YesYes696
78B:B:C218 B:B:K209 24.00836.47NoYes656
79B:B:C218 G:G:Q18 47.91224.58NoNo059
80G:G:M21 G:G:Q18 47.4625.44NoNo019
81B:B:M217 G:G:M21 47.01132.89NoNo031
82B:B:E215 B:B:M217 23.279910.83NoNo1933
83B:B:D212 B:B:E215 22.816411.69NoNo1993
84B:B:D212 B:B:L198 44.69374.07NoNo093
85B:B:D195 B:B:L198 43.75392.71NoNo053
86B:B:A193 B:B:D195 40.93164.63NoNo045
87B:B:A193 B:B:F234 38.10485.55NoNo045
88B:B:F234 B:B:V200 36.2186.55NoNo056
89B:B:F241 B:B:V200 28.60039.18YesNo566
90B:B:F222 B:B:F241 18.136410.72YesYes586
91B:B:D258 B:B:F222 12.46873.58YesYes578
92B:B:H183 B:B:W211 24.42765.29YesYes698
93B:B:C218 B:B:W211 24.35345.22NoYes658
94B:B:M217 B:B:R219 23.27994.96NoNo1935
95B:B:D212 B:B:R219 22.816411.91NoNo1995
96B:B:D290 B:B:R314 28.346621.44NoNo068
97B:B:C271 B:B:D290 25.93533.11NoNo056
98B:B:C271 B:B:D291 25.12776.22NoNo058
99B:B:D291 B:B:Y289 23.91265.75NoYes087
100B:B:W297 B:B:Y289 18.07537.72YesYes2087
101B:B:W297 B:B:Y264 16.035213.5YesYes085
102B:B:M325 G:G:P49 47.5475.03YesYes057
103G:G:D48 G:G:P49 43.5643.22YesYes097
104G:G:D48 G:G:L51 21.35055.43YesYes096
105B:B:M325 G:G:F61 30.45723.73YesYes058
106B:B:S279 G:G:D48 21.346110.31NoYes099
107B:B:S279 G:G:L50 20.66476.01NoNo099
108B:B:M45 G:G:L50 19.98274.24NoNo049
109B:B:L308 B:B:M45 19.30024.24NoNo074
110B:B:L308 B:B:W339 18.617312.53NoYes079
111B:B:T321 B:B:W63 12.973112.13NoYes077
112B:B:I338 G:G:F61 13.86143.77NoYes058
113B:B:D323 B:B:M325 12.73536.93NoYes075
114B:B:G162 B:B:Y145 16.32064.35NoYes198
115B:B:G162 B:B:S161 16.12223.71NoNo199
116B:B:H142 B:B:S161 14.375212.55YesNo199
117B:B:H142 B:B:T159 10.32714.11YesYes199
118R:R:I135 R:R:R139 67.00995.01YesNo099
119R:R:I135 R:R:M82 57.31134.37YesYes499
120R:R:D86 R:R:M82 22.0035.54YesYes499
121R:R:D86 R:R:S331 16.77548.83YesNo099
122R:R:S331 R:R:V89 16.53086.46NoNo097
123R:R:C124 R:R:V89 16.28823.42NoNo067
124R:R:C124 R:R:V93 15.82813.42NoNo067
125R:R:V93 R:R:Y328 15.21763.79NoYes277
126R:R:M82 R:R:N334 35.99564.21YesYes499
127R:R:N330 R:R:N334 37.703912.26NoYes099
128R:R:N330 R:R:W298 37.270914.69NoYes098
129R:R:C125 R:R:W298 17.20385.22NoYes068
130L:L:?1 R:R:C125 16.952311.17YesNo006
131R:R:F302 R:R:W298 17.20347.02NoYes268
132L:L:?1 R:R:F302 17.045115YesNo206
133L:L:?1 R:R:F301 19.53515.36YesYes207
134R:R:F301 R:R:F323 18.88413.22YesYes075
135A:A:F215 A:A:L37 10.324718.27YesNo199
136B:B:S84 G:G:F61 13.78485.28NoYes1058
137B:B:I338 B:B:W63 13.94024.7NoYes057
138B:B:D323 B:B:T321 12.73967.23NoNo077
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D121 R:R:V93 7.3 2 No No 8 7 1 2
R:R:V93 R:R:Y328 3.79 2 No Yes 7 7 2 2
R:R:D121 R:R:Y328 8.05 2 No Yes 8 7 1 2
L:L:?1 R:R:D121 10.75 2 Yes No 0 8 0 1
L:L:?1 R:R:V122 10.49 2 Yes No 0 7 0 1
R:R:C125 R:R:W298 5.22 0 No Yes 6 8 1 2
L:L:?1 R:R:C125 11.17 2 Yes No 0 6 0 1
R:R:A208 R:R:T126 3.36 0 No No 7 7 1 2
L:L:?1 R:R:V194 7.86 2 Yes No 0 4 0 1
R:R:S204 R:R:Y200 8.9 0 No No 6 7 1 2
L:L:?1 R:R:S204 7.93 2 Yes No 0 6 0 1
L:L:?1 R:R:A208 4.16 2 Yes No 0 7 0 1
R:R:F209 R:R:W298 7.02 2 Yes Yes 8 8 2 2
R:R:F209 R:R:F302 25.72 2 Yes No 8 6 2 1
R:R:F302 R:R:W298 7.02 2 No Yes 6 8 1 2
R:R:E305 R:R:F301 16.32 2 No Yes 7 7 1 1
R:R:F301 R:R:L324 7.31 2 Yes No 7 5 1 2
L:L:?1 R:R:F301 5.36 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F302 15 2 Yes No 0 6 0 1
L:L:?1 R:R:E305 13.99 2 Yes No 0 7 0 1
R:R:L324 R:R:Y328 11.72 0 No Yes 5 7 2 2
R:R:S173 R:R:V122 3.23 0 Yes No 8 7 2 1
R:R:F301 R:R:F323 3.22 2 Yes Yes 7 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
90.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
90.00Single8GGKEpinephrine8GGK-β2-Epinephrine
90.00Single8GGLEpinephrine8GGL-β2-Epinephrine
90.00Single8GGMEpinephrine8GGM-β2-Epinephrine
90.00Single8GGPEpinephrine8GGP-β2-Epinephrine
88.89Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
88.89Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
88.89Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
81.82Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
81.82Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
81.82Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
81.82Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
81.82Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
81.82Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
81.82Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GGJEpinephrine8GGJ-β2-Epinephrine
81.82Single8GGNEpinephrine8GGN-β2-Epinephrine
81.82Single8GGOEpinephrine8GGO-β2-Epinephrine
81.82Single8GGUEpinephrine8GGU-β2-Epinephrine
81.82Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
81.82Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
81.82Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
81.82Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
81.82Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
80.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
80.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
80.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
80.00Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
80.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
75.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
75.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
75.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
75.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
75.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
75.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
75.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
75.00Single7XKAEpinephrine7XKA-β2-Epinephrine
75.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
75.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
75.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
75.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
75.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
75.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
75.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
75.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
72.73Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
72.73Single6A94Zotepine6A94-5-HT2A-Zotepine
72.73Single6PS4ICI 118-5516PS4-β2-ICI 118-551
72.73Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
72.73Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
72.73Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
72.73Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
72.73Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
72.73Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
72.73Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
72.73Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GGIEpinephrine8GGI-β2-Epinephrine
72.73Single8GGQEpinephrine8GGQ-β2-Epinephrine
72.73Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
72.73Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
72.73Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
72.73Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
70.00Single3PBLEticlopride3PBL-D3-Eticlopride
70.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
70.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
70.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
70.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
70.00Single8GGSEpinephrine8GGS-β2-Epinephrine
70.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
70.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
69.23Single3P0GBI1671073P0G-β2-BI167107
69.23Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
69.23Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
69.23Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
69.23Single6H7JIsoprenaline6H7J-β1-Isoprenaline
69.23Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
69.23Single6WGTLSD6WGT-5-HT2A-LSD
69.23Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
69.23Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
69.23Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
69.23Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
69.23Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
69.23Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
69.23Consensus5ht5_offOrthosteric Ligand5ht5a_off
69.23Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
69.23Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
69.23Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
69.23Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
69.23Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
66.67Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
66.67Single2Y02Carmoterol2Y02-β1-Carmoterol
66.67Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
66.67Single3NY8ICI 118-5513NY8-β2-ICI 118-551
66.67Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
66.67Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
66.67Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
66.67Single6H7MSalbutamol6H7M-β1-Salbutamol
66.67Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
66.67Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
66.67Single6PS1Timolol6PS1-β2-Timolol
66.67Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
66.67Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
66.67Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
66.67Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single7WC7Lisuride7WC7-5-HT2A-Lisuride
66.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
66.67Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
66.67Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
66.67Single8JJOAlprenolol8JJO-β2-Alprenolol
66.67Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8X64Desloratadine8X64-H1-Desloratadine
66.67Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
66.67Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
66.67Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
66.67Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
66.67Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
64.29Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
64.29Single4AMIBucindolol4AMI-β1-Bucindolol
64.29Single4LDEBI1671074LDE-β2-BI167107
64.29Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
64.29Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
64.29Single6MXTSalmeterol6MXT-β2-Salmeterol
64.29Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
64.29Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
64.29Single8JJ8Formoterol8JJ8-β2-Formoterol
64.29Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
63.64Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
63.64Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
63.64Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
63.64Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
63.64Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
63.64Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
63.64Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GGVEpinephrine8GGV-β2-Epinephrine
63.64Single8GGWEpinephrine8GGW-β2-Epinephrine
63.64Single8GGXEpinephrine8GGX-β2-Epinephrine
63.64Single8GH0Epinephrine8GH0-β2-Epinephrine
63.64Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
63.64Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
61.54Single2Y03Isoprenaline2Y03-β1-Isoprenaline
61.54Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
61.54Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
61.54Single5TVNLSD5TVN-5-HT2B-LSD
61.54Single5WIUNemonapride5WIU-D4-Nemonapride
61.54Single5WIVNemonapride5WIV-D4-Nemonapride-Na
61.54Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
61.54Single7WC6LSD7WC6-5-HT2A-LSD
61.54Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
61.54Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
61.54Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
61.54Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
61.54Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
61.54Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
61.54Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
61.54Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
60.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
60.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
60.00Single6H7LDobutamine6H7L-β1-Dobutamine
60.00Single6IBLArformoterol6IBL-β1-Arformoterol
60.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
60.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
60.00Single8GGREpinephrine8GGR-β2-Epinephrine
60.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
60.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
60.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
58.33Single3RZECidoxepin3RZE-H1-Cidoxepin
58.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
58.33Single6TPNHTL66416TPN-OX2-HTL6641
58.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
58.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
58.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
58.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
58.33Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GGTEpinephrine8GGT-β2-Epinephrine
58.33Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
58.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
58.33Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Consensus5ht5_onOrthosteric Ligand5ht5a_on
58.33Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
58.33Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
57.14Single2YDVNECA2YDV-A2A-NECA
57.14Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
57.14Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
57.14Single4UHRCGS216804UHR-A2A-CGS21680
57.14Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
57.14Single5G53NECA5G53-A2A-NECA-Gs
57.14Single6J20Aprepitant6J20-NK1-Aprepitant
57.14Single6J21Aprepitant6J21-NK1-Aprepitant
57.14Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
57.14Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
57.14Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
57.14Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
57.14Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
57.14Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
57.14Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
57.14Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
57.14Consensushistamine_offOrthosteric Ligandh1_off
56.25Single3NY9PubChem 9131033NY9-β2-PubChem 913103
54.55Single6HLLCP999946HLL-NK1-CP99994
54.55Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
54.55Single7SRQLSD7SRQ-5-HT2B-LSD
54.55Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
54.55Single8GGYEpinephrine8GGY-β2-Epinephrine
54.55Single8GH1Epinephrine8GH1-β2-Epinephrine
54.55Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
54.55Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
54.55Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
54.55Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
53.85Single2Y04Salbutamol2Y04-β1-Salbutamol
53.85Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
53.85Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
53.85Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
53.85Single7BU7BI1671077BU7-β1-BI167107
53.85Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
53.85Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
53.85Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
53.85Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
53.85Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
53.85Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
53.85Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8X63Mepyramine8X63-H1-Mepyramine
53.85Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
53.85Consensustachykinin_offOrthosteric Ligandnk1_off
53.85Consensustar_onOrthosteric Ligandta1_on
53.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
53.33Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
53.33Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
53.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
53.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
53.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
53.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
53.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
53.33Single8JJLOlodaterol8JJL-β2-Olodaterol
53.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
53.33Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
53.33Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
52.94Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
52.94Single4IARErgotamine4IAR-5-HT1B-Ergotamine
52.94Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
50.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
50.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
50.00Single5C1MBU725C1M-μ-BU72
50.00Single6AKXA4R6AKX-CCR5-A4R
50.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
50.00Single6KUXRS-799486KUX-α2a-RS-79948
50.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
50.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
50.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
50.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
50.00Single6PS6Timolol6PS6-β2-Timolol
50.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
50.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
50.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
50.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
50.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
50.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
50.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
50.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
50.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
50.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
50.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
50.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
47.06Single4UG2CGS216804UG2-A2A-CGS21680
47.06Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single8X5YAstemizole8X5Y-H1-Astemizole
46.67Single4RWADIPP-NH24RWA-δ-DIPP-NH2
46.67Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
46.67Single4U15Tiotropium4U15-M3-Tiotropium
46.67Single5V54Methiothepin5V54-5-HT1B-Methiothepin
46.67Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
46.67Single6E59L-7607356E59-NK1-L-760735
46.67Single6OL9Tiotropium6OL9-M5-Tiotropium
46.67Single6TQ7SB-3348676TQ7-OX1-SB-334867
46.67Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
46.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
46.67Single8E0GBU728E0G-μ-BU72
46.67Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
46.67Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
46.67Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
46.67Consensus5ht1_offOrthosteric Ligand5ht1b_off
46.67Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
46.67Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
46.67Consensusa2_onOrthosteric Liganda2a_on a2b_on
46.67Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
46.67Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
46.67Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
46.67Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
46.15Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
46.15Single4MBSMaraviroc4MBS-CCR5-Maraviroc
46.15Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
46.15Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
46.15Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
46.15Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
46.15Single6TPGEMPA6TPG-OX2-EMPA
46.15Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
46.15Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
46.15Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
46.15Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
46.15Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
46.15Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
46.15Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
46.15Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
46.15Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
45.45Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
45.45Single8GGZEpinephrine8GGZ-β2-Epinephrine
45.45Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.44Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
43.75Single5CXVTiotropium5CXV-M1-Tiotropium
43.75Single6HLPNetupitant6HLP-NK1-Netupitant
43.75Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
43.75Single7YITNalfurafine7YIT-κ-Nalfurafine
43.75Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
43.75Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
43.75Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
43.75Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
42.86Single2Y01Dobutamine2Y01-β1-Dobutamine
42.86Single4DAJTiotropium4DAJ-M3-Tiotropium
42.86Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
42.86Single4EJ4Naltrindole4EJ4-δ-Naltrindole
42.86Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
42.86Single4MQSIperoxo4MQS-M2-Iperoxo
42.86Single4U14Tiotropium4U14-M3-Tiotropium
42.86Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
42.86Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
42.86Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
42.86Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
42.86Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
42.86Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
42.86Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
42.86Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
42.86Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
42.86Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
42.86Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
42.86Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
42.86Single7UL4Alvimopan7UL4-μ-Alvimopan
42.86Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
42.86Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
42.86Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
42.86Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
42.86Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
42.86Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
42.86Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
42.86Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
42.86Consensushistamine_onOrthosteric Ligandh1_on h4_on
42.86Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
42.11Single6HLOAprepitant6HLO-NK1-Aprepitant
41.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
41.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
41.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
41.67Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
41.67Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
41.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
41.18Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
41.18Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
41.18Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
41.18Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
41.18Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
41.18Consensusendothelin_offOrthosteric Ligandetb_off
41.18Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
41.18Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
40.00Single2Y00Dobutamine2Y00-β1-Dobutamine
40.00Single5WQCEMPA5WQC-OX2-EMPA
40.00Single5XPRBosentan5XPR-ETB-Bosentan
40.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
40.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
40.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
40.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
40.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
40.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
40.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
40.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
40.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
40.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
40.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8EA0Iperoxo8EA0-M3-Iperoxo
40.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
40.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
40.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
40.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
40.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
40.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single6PT3DPI-2876PT3-δ-DPI-287
38.89Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
38.46Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
38.46Single5DHHSB-6121115DHH-NOP-SB-612111
38.46Single6AKYMaraviroc6AKY-CCR5-Maraviroc
38.46Single6B73PubChem 1319551386B73-κ-PubChem 131955138
38.46Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
38.46Single6TODEMPA6TOD-OX1-EMPA-Na
38.46Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
38.46Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
38.46Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
38.46Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
38.46Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
38.46Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
38.46Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single8IWESpermidine8IWE-TAAR9-Spermidine
38.46Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
38.46Consensusorexin_offOrthosteric Ligandox2_off ox1_off
38.10Single7C61Ergotamine7C61-5-HT1B-Ergotamine
37.50Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
37.50Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
37.50Single5X93K-87945X93-ETB-K-8794
37.50Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
37.50Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
37.50Single7B6WCyclazosin7B6W-α1b-Cyclazosin
37.50Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
37.50Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
37.50Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
37.50Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
37.50Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
37.50Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
37.50Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
37.50Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
37.50Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
37.50Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
37.50Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
36.84Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
36.84Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
36.84Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
36.36Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
36.36Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
36.36Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.36Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
36.36Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
36.36Consensussensory_onOrthosteric Ligandopsin_on
35.71Single2YDOAdenosine2YDO-A2A-Adenosine
35.71Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
35.71Single4ZJCSB-6740424ZJC-OX1-SB-674042
35.71Single6IQLL7458706IQL-D4-L745870
35.71Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
35.71Single6VI4JDTic6VI4-κ-JDTic
35.71Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
35.71Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
35.71Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
35.71Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.71Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
35.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.71Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
35.71Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.71Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
35.29Single6CM4Risperidone6CM4-D2-Risperidone
35.29Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.29Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
35.29Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
35.29Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
35.29Single8JWZAB9288JWZ-A2A-AB928-Na
35.29Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Single3QAKUK-4320973QAK-A2A-UK-432097
35.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
33.33Single3UZAGTPL92363UZA-A2A-GTPL9236
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single5DSGTiotropium5DSG-M4-Tiotropium
33.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
33.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
33.33Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
33.33Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single5WF5UK-4320975WF5-A2A-UK-432097
33.33Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
33.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
33.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
33.33Single6ME9Ramelteon6ME9-MT2-Ramelteon
33.33Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
33.33Single6PT2KGCHM076PT2-δ-KGCHM07
33.33Single6TOTLemborexant6TOT-OX1-Lemborexant
33.33Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
33.33Single7EZCUKA7EZC-A2A-UKA
33.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
33.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
33.33Single7WC5Psilocin7WC5-5-HT2A-Psilocin
33.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
33.33Single8CU6LJ-45178CU6-A2A-LJ-4517
33.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
33.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
33.33Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
33.33Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
33.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
33.33Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
33.33Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
33.33Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
33.33Consensusadenosine_onOrthosteric Liganda1_on a2_on
33.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
33.33Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
33.33Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
33.33Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
33.33Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
33.33Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
33.33Consensusnucleotide_onOrthosteric Ligandadenosine_on
33.33Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
33.33Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Consensusorexin_onOrthosteric Ligandox2_on
31.82Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
31.82Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single5WF6UK-4320975WF6-A2A-UK-432097
31.58Single5ZTYAM102575ZTY-CB2-AM10257
31.58Single7SK9CCX6627SK9-ACKR3-CCX662
31.58Single7XN9L-054,5227XN9-SST2-L-054,522
31.58Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
31.58Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
31.58Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
31.58Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.58Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
31.58Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
31.58Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.25Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
31.25Single5NM2ZM2413855NM2-A2A-ZM241385-Na
31.25Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
31.25Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
31.25Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
31.25Single6LUQHaloperidol6LUQ-D2-Haloperidol
31.25Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
31.25Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
31.25Single6TP6Filorexant6TP6-OX1-Filorexant
31.25Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.25Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.25Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
31.25Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
31.25Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
31.25Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
31.25Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
31.25Single8QOTNanobody E8QOT-μ-Nanobody E
31.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
31.25Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
30.77Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
30.77Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
30.77Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
30.77Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
30.77Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
30.77Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
30.77Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
30.77Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
30.77Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
30.77Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
30.77Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
30.77Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
30.43Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
30.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
30.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
30.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
30.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
30.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
29.41Single4DJHJDTic4DJH-κ-JDTic
29.41Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
29.41Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
29.41Single7EPENAM5637EPE-mGlu-NAM563
29.41Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
29.41Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
29.41Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
29.41Single7TUYGSK682753A7TUY-GPR183-GSK682753A
29.41Single7W41PD1762527W41-BB2-PD176252
29.41Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
29.41Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
29.41Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
29.41Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
29.41Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
29.41Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
29.41Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
29.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
29.41Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
29.41Consensusadenosine_offOrthosteric Liganda1_off a2_off
29.41Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
29.41Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
29.41Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
29.41Consensusbombesin_offOrthosteric Ligandbb2_off
29.41Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
29.41Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
29.41Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
29.41Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
29.41Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
29.41Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
29.41Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
29.41Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
29.17Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
28.57Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
28.57Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
28.57Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
28.57Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
28.57Single5K2DZM2413855K2D-A2A-ZM241385
28.57Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
28.57Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
28.57Single5WS3EMPA5WS3-OX2-EMPA
28.57Single6JZHZM2413856JZH-A2A-ZM241385-Na
28.57Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57Single6PS7ZM2413856PS7-A2A-ZM241385-Na
28.57Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
28.57Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
28.57Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7F8ULintitript7F8U-CCKA-Lintitript
28.57Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
28.57Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
28.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
28.57Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
28.57Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
28.57Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Single7XRRLemborexant7XRR-OX2-Lemborexant
28.57Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
28.57Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
28.57Single8GNGIstradefylline8GNG-A2A-Istradefylline
28.57Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
28.57Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
28.57Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
28.57Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
28.57Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
28.57Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
28.57Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
28.57Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
28.57Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgt_class-aOrthosteric Ligandgt_opsin
28.57Consensusgt_opsinOrthosteric Ligandgt_sensory
28.57Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
28.57Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
28.57Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
28.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
27.78Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.78Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.78Single6A93Risperidone6A93-5-HT2A-Risperidone
27.78Single6ZG4HTL00099366ZG4-M1-HTL0009936
27.78Single7DFPSpiperone7DFP-D2-Spiperone
27.78Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
27.78Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.78Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
27.78Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
27.78Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
27.78Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
27.78Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
27.78Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
27.78Single8WU1KCA8WU1-CB1-KCA-Arrestin1
27.78Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
27.78Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
27.78Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.78Consensusgs_steroidOrthosteric Ligandgs_bileacid
27.78Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
27.78Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.78Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
27.27Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
27.27Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
27.27Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
27.27Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
27.27Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
27.27Single7WC4Serotonin7WC4-5-HT2A-Serotonin
27.27Single8PWNTheophylline8PWN-A2A-Theophylline
27.27Consensusangiotensin_onOrthosteric Ligandat1_on
27.27Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
27.27Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.92Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
26.92Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
26.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
26.67Single3REYPubChem 56973REY-A2A-PubChem 5697
26.67Single5IU4ZM2413855IU4-A2A-ZM241385-Na
26.67Single5IU7Q274563465IU7-A2A-Q27456346-Na
26.67Single5IUBQ274563445IUB-A2A-Q27456344-Na
26.67Single5JTBZM2413855JTB-A2A-ZM241385
26.67Single5K2BZM2413855K2B-A2A-ZM241385-Na
26.67Single5K2CZM2413855K2C-A2A-ZM241385-Na
26.67Single5NLXZM2413855NLX-A2A-ZM241385-Na
26.67Single5NM4ZM2413855NM4-A2A-ZM241385-Na
26.67Single5UVIZM2413855UVI-A2A-ZM241385
26.67Single6AQFZM2413856AQF-A2A-ZM241385
26.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
26.67Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
26.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
26.67Single6TPKRetosiban6TPK-OT-Retosiban
26.67Single6V9SGTPL114036V9S-OX1-GTPL11403
26.67Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
26.67Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
26.67Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.67Single7AROLUF58337ARO-A2A-LUF5833-Na
26.67Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
26.67Single7T32ZM2413857T32-A2A-ZM241385
26.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
26.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
26.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
26.67Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
26.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
26.67Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
26.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
26.67Consensussensory_offOrthosteric Ligandopsin_off
26.67Consensusvasopressin-ot_offOrthosteric Ligandot_off
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
26.32Single6K1QIRL25006K1Q-ETB-IRL2500
26.32Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
26.32Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
26.32Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
26.32Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
26.32Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
26.32Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
26.32Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
26.32Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.32Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.32Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
26.32Consensussteroid_onOrthosteric Ligandbileacid_on
26.09Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.09Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
26.09Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.93Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.93Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.93Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single3EMLZM2413853EML-A2A-ZM241385
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
25.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
25.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
25.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
25.00Single6LPJZM2413856LPJ-A2A-ZM241385-Na
25.00Single6LPKZM2413856LPK-A2A-ZM241385-Na
25.00Single6S0LZM2413856S0L-A2A-ZM241385
25.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
25.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
25.00Single7PYRPSB-21157PYR-A2A-PSB-2115
25.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
25.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
25.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusa2_offOrthosteric Liganda2a_off
25.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
25.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
25.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
25.00Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
25.00Consensuscck_offOrthosteric Ligandccka_off
25.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
25.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
25.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
25.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Consensusgi_hcarOrthosteric Ligandgi_hca
25.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
25.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
24.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
24.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
23.81Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single7F8XNN90567F8X-CCKA-NN9056
23.81Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.81Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.81Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
23.81Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
23.81Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
23.81Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.53Single4NTJAZD12834NTJ-P2Y12-AZD1283
23.53Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
23.53Single5IUAQ274563485IUA-A2A-Q27456348-Na
23.53Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
23.53Single5N2SPSB365N2S-A1-PSB36
23.53Single6D26Fevipiprant6D26-DP2-Fevipiprant
23.53Single6LPLZM2413856LPL-A2A-ZM241385-Na
23.53Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.53Single6S0QZM2413856S0Q-A2A-ZM241385
23.53Single6WQAZM2413856WQA-A2A-ZM241385-Na
23.53Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.53Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
23.53Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
23.53Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
23.53Single7RM5ZM2413857RM5-A2A-ZM241385-Na
23.53Single7SINNPS-21437SIN-CaS-NPS-2143
23.53Single7SINNPS-21437SIN-CaS-NPS-2143
23.53Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
23.53Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
23.53Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8FYNZM2413858FYN-A2A-ZM241385-Na
23.53Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.53Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.53Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
23.53Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
23.53Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.53Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.53Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
23.53Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
23.33Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.33Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.33Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
23.08Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
23.08Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
23.08Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
23.08Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
23.08Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
23.08Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
23.08Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
23.08Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.08Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
23.08Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
23.08Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
23.08Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
23.08Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.08Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
22.73Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
22.73Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
22.73Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
22.73Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
22.73Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
22.22Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
22.22Single5XR8AM8415XR8-CB1-AM841
22.22Single5XRAAM115425XRA-CB1-AM11542
22.22Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
22.22Single6IGLIRL16206IGL-ETB-IRL1620
22.22Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
22.22Single7PX4PSB-21137PX4-A2A-PSB-2113
22.22Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
22.22Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.22Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.22Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.22Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
22.22Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
22.22Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
22.22Consensuscck_onOrthosteric Ligandccka_on cckb_on
22.22Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
22.22Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.22Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.22Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
22.22Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Consensuslpa_offOrthosteric Ligandlpa1_off
22.22Consensuslpa_onOrthosteric Ligandlpa1_on
22.22Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
21.74Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
21.74Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.43Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
21.43Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
21.43Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.43Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
21.43Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
21.43Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.43Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
21.43Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
21.43Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
21.43Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
21.43Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
21.43Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
21.43Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
21.43Single8K5BNiacin8K5B-HCA2-Niacin
21.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.05Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.05Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.05Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.05Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.05Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
21.05Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
21.05Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
21.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
21.05Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
21.05Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.05Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
21.05Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.05Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
21.05Consensusdp_offOrthosteric Liganddp2_off
21.05Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
21.05Consensusgi_class-fOther Ligandgi_frizzled
21.05Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.05Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
21.05Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
21.05Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
21.05Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.83Single6JODAngiotensin II6JOD-AT2-Angiotensin II
20.83Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
20.83Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.83Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
20.69Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.69Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
20.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
20.00Single3PWHZM2413853PWH-A2A-ZM241385
20.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
20.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
20.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
20.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
20.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
20.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
20.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
20.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
20.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
20.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
20.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
20.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
20.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
20.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
20.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.35Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.23Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
19.23Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
19.23Consensusclass-d_onOrthosteric Ligandste2_on
19.23Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
19.23Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
19.05Single5EE7MK08935EE7-Glucagon-MK0893
19.05Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
19.05Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.05Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
19.05Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
19.05Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
19.05Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusclass-d_offOrthosteric Ligandste2_off
19.05Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
19.05Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.05Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
18.75Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
18.75Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
18.75Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
18.75Single6MH8ZM2413856MH8-A2A-ZM241385
18.75Single6TP3Nemorexant6TP3-OX1-Nemorexant
18.75Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
18.75Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.75Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
18.75Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
18.75Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
18.75Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
18.75Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
18.75Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
18.75Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
18.75Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
18.75Single8K5CAcipimox8K5C-HCA2-Acipimox
18.75Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
18.75Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
18.75Consensusgnrh_offOrthosteric Ligandgnrh1_off
18.75Consensushca_onOrthosteric Ligandhca2_on hca3_on
18.75Consensushcar_onOrthosteric Ligandhca_on
18.75Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
18.75Consensuss1p_offOrthosteric Ligands1p1_off
18.52Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
18.52Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
18.52Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
18.52Consensusgi_class-dOrthosteric Ligandgi_ste
18.52Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Consensusgo_class-b1Orthosteric Ligandgo_crf
18.52Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.18Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
18.18Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
18.18Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
18.18Single7QA8Peptide7QA8-STE2-Peptide
18.18Single7QA8Peptide7QA8-STE2-Peptide
18.18Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
18.18Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
18.18Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
18.18Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
18.18Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
18.18Consensusclass-d_offOrthosteric Ligandste2_off
18.18Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.86Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
17.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.86Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
17.86Single8IY6Endothelin-18IY6-ETB-Endothelin-1
17.65Single4YAYZD-71554YAY-AT1-ZD-7155
17.65Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
17.65Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
17.65Single6D27CAY104716D27-DP2-CAY10471
17.65Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
17.65Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
17.65Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
17.65Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
17.65Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
17.65Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.65Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
17.65Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
17.65Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
17.65Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
17.65Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
17.65Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
17.65Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
17.65Single8K5DGSK2560738K5D-HCA2-GSK256073
17.65Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
17.65Consensusblt_onOrthosteric Ligandblt1_on
17.65Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
17.65Consensusleuko_onOrthosteric Ligandblt_on
17.65Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
17.39Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
17.39Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
17.39Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.39Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.39Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
17.39Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
17.39Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
17.24Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.67Single5CGCHTL142425CGC-mGlu5-HTL14242
16.67Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
16.67Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
16.67Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
16.67Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
16.67Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
16.67Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.67Single6W25SHU91196W25-MC4-SHU9119-Ca
16.67Single7C4SS1P7C4S-S1P3-S1P
16.67Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
16.67Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
16.67Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
16.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
16.67Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
16.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
16.67Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
16.67Consensusclass-c_onOther Ligandgabab_on mglu_on
16.67Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
16.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
16.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
16.00Consensusclass-d_onOrthosteric Ligandste2_on
16.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.00Consensusgi_class-dOrthosteric Ligandgi_ste
16.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.79Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
15.79Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.79Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.79Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.79Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
15.79Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
15.79Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.79Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
15.79Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
15.79Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
15.79Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
15.79Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
15.79Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
15.79Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
15.79Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
15.79Consensuschemerin_onOrthosteric Ligandcml1_on
15.79Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.62Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.38Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
15.38Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
15.38Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
15.38Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
15.38Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
15.38Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.38Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
15.38Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
15.38Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Consensuspth_onOrthosteric Ligandpth1_on pth2_on
15.00Single4N4WSANT-14N4W-SMO-SANT-1
15.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
15.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
15.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
15.00Single7K15MKD0467K15-BLT1-MKD046-Na
15.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
15.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
15.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
15.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
15.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
15.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
15.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
15.00Consensusblt_offOrthosteric Ligandblt1_off
15.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
15.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
14.81Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
14.81Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
14.81Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
14.29Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
14.29Single5CGDHTL142425CGD-mGlu5-HTL14242
14.29Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
14.29Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.29Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
14.29Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.29Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
14.29Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
14.29Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
14.29Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
14.29Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.29Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
14.29Consensuscyslt_offOrthosteric Ligandcyslt2_off
14.29Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
14.29Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.29Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
14.29Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single6LMLGlucagon6LML-Glucagon-Glucagon
13.79Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.79Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
13.79Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
13.79Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.79Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
13.64Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
13.64Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
13.64Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
13.64Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
13.64Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
13.64Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
13.64Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
13.64Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
13.64Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
13.64Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.64Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
13.33Single3OE9IT1t3OE9-CXCR4-IT1t
13.33Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
13.33Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
13.33Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.33Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
13.33Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
13.33Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
13.33Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
13.33Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusclass-t_onOrthosteric Ligandtaste2_on
13.33Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.33Consensusgo_class-b2Orthosteric Ligandgo_adhesion
13.33Consensusgs_class-tOrthosteric Ligandgs_taste
13.33Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.33Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.16Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
13.16Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
13.04Single4XT1Fractalkine4XT1-US28-Fractalkine
13.04Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
13.04Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.04Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
13.04Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.04Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
13.04Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
13.04Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
12.90Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.90Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.90Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
12.90Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.50Single7F8YDevazepide7F8Y-CCKA-Devazepide
12.50Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
12.50Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
12.50Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.50Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
12.50Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
12.50Single8IHKAcifran8IHK-HCA3-Acifran
12.50Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
12.50Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.50Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
12.50Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
12.50Consensussst_offOrthosteric Ligandsst2_off
12.12Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
12.12Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
12.12Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.12Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
12.00Single3OE0CVX153OE0-CXCR4-CVX15
12.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
12.00Single7XNACYN1548067XNA-SST2-CYN154806
12.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
12.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
12.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
11.76Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
11.76Single6FFIMMPEP6FFI-mGlu5-MMPEP
11.76Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
11.76Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
11.76Single6ZG9GSK10347026ZG9-M1-GSK1034702
11.76Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
11.76Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
11.76Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
11.76Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
11.76Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
11.76Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
11.54Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
11.54Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
11.54Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.54Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.11Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
11.11Single5TGZAM65385TGZ-CB1-AM6538
11.11Single6FFHFenobam6FFH-mGlu5-Fenobam
11.11Single6GPSMK08126GPS-CCR2-MK0812
11.11Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
11.11Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
11.11Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.11Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
11.11Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
11.11Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
11.11Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
11.11Consensusclass-c_offOther Ligandgabab_off mglu_off
11.11Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
11.11Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
11.11Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
10.81Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
10.71Single4XT3Fractalkine4XT3-US28-Fractalkine
10.71Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
10.71Single6FJ3PTH6FJ3-PTH1-PTH
10.71Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.71Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.71Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.71Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
10.71Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.71Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
10.71Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.71Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
10.71Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.53Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
10.53Single6GPXMK08126GPX-CCR2-MK0812
10.53Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.53Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
10.53Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
10.53Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
10.53Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
10.53Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
10.53Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.53Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.53Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.53Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
10.53Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
10.34Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
10.34Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
10.34Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
10.34Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.34Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
10.34Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
10.00Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.00Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
10.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
10.00Single7P2L4YI7P2L-mGlu5-4YI
10.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
10.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
10.00Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
10.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
10.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
10.00Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
9.52Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
9.52Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.52Single4XEENeurotensin4XEE-NTS1-Neurotensin
9.52Single4XESNeurotensin4XES-NTS1-Neurotensin
9.52Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
9.52Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
9.52Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
9.52Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
9.52Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
9.52Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
9.52Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.52Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
9.52Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
9.52Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
9.52Consensusnts_offOrthosteric Ligandnts1_off
9.52Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
9.09Single4BUONeurotensin4BUO-NTS1-Neurotensin
9.09Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
9.09Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
9.09Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
9.09Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
9.09Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
9.09Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
9.09Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
8.82Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.70Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.70Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
8.70Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusgs_class-b2Orthosteric Ligandgs_adgr
8.70Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
8.57Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.33Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
8.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
8.11Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
8.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
8.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
8.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
8.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
8.00Single7SHEPI; PE7SHE-GPR158-PI; PE
8.00Single7SK5CXCL127SK5-ACKR3-CXCL12
8.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
8.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
7.69Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
7.69Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.69Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.69Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
7.69Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
7.69Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.41Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
7.41Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
7.41Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
7.14Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.14Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
7.14Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
7.14Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
7.14Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
7.14Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
7.14Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
6.90Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
6.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.90Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.90Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.90Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
6.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.67Single3OE6IT1t3OE6-CXCR4-IT1t
6.67Single3OE8IT1t3OE8-CXCR4-IT1t
6.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
6.67Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
6.67Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
6.67Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
6.67Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
6.67Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.45Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
6.45Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
6.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.25Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
6.25Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
6.06Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
6.06Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.88Single3ODUIT1t3ODU-CXCR4-IT1t
5.88Single5U09Taranabant5U09-CB1-Taranabant
5.88Single5ZKQABT-4915ZKQ-PAF-ABT-491
5.88Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.88Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
5.88Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.88Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.88Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.88Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.88Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.71Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.56Single6ZINSR486926ZIN-NTS1-SR48692
5.56Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.56Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single7VV6C48/807VV6-MRGPRX2-C48/80
5.56Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.56Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
5.56Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
5.56Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8IYXYL-3658IYX-GPR34-YL-365
5.56Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.26Single6IIVDaltroban6IIV-TP-Daltroban
5.26Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.26Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
5.26Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.26Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.26Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.26Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
5.26Consensushcar_offOrthosteric Ligandsuccinate_off
5.26Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
5.26Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
5.26Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
5.13Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
5.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
5.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
5.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.00Single6Z4SSR486926Z4S-NTS1-SR48692
5.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
5.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
5.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
5.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
5.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
5.00Consensusep_offOrthosteric Ligandep4_off
4.76Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.76Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.76Single5V56TC1145V56-SMO-TC114
4.76Single6OS1TRV0266OS1-AT1-TRV026
4.76Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.76Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.76Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.76Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
4.76Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.76Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.76Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.55Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
4.55Single5X33BIIL2605X33-BLT1-BIIL260
4.55Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
4.55Single6IIURamatroban6IIU-TP-Ramatroban
4.55Single6OS2TRV0266OS2-AT1-TRV026
4.55Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
4.55Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.55Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
4.55Single7SHEPI; PE7SHE-GPR158-PI; PE
4.55Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.55Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.55Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.55Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.55Consensusnts_onOrthosteric Ligandnts1_on
4.35Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.35Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.35Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.35Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
4.35Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
4.35Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.35Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.35Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
4.35Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.35Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single6KNMJN241-96KNM-Apelin-JN241-9
4.17Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
4.17Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
4.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
4.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.85Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.57Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
3.45Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
3.33Single7SK3CXCL127SK3-ACKR3-CXCL12
3.23Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
3.23Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.12Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.12Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
3.12Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
3.12Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.12Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.03Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.03Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.03Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.03Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.03Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.94Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.86Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.86Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.86Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
2.78Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.78Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.63Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.63Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.50Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.44Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.44Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 7X5H
Class A
SubFamily Amine
Type 5-Hydroxytryptamine
SubType 5-HT5A
Species Homo sapiens
Ligand 5-CT
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.1
Date 2022-09-14
D.O.I. 10.1038/s41421-022-00412-3
Net Summary
Imin 3.25
Number of Linked Nodes 833
Number of Links 975
Number of Hubs 140
Number of Links mediated by Hubs 539
Number of Communities 32
Number of Nodes involved in Communities 228
Number of Links involved in Communities 311
Path Summary
Number Of Nodes in MetaPath 139
Number Of Links MetaPath 138
Number of Shortest Paths 765437
Length Of Smallest Path 3
Average Path Length 42.3351
Length of Longest Path 100
Minimum Path Strength 1.275
Average Path Strength 6.9777
Maximum Path Strength 26.34
Minimum Path Correlation 0.7
Average Path Correlation 0.977362
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.88679
Average % Of Corr. Nodes 40.4429
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.0038
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code8K3
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code8K3
Name3-(2-azanylethyl)-1H-indole-5-carboxamide
Synonyms
Identifier3-(2-azanylethyl)-1~{H}-indole-5-carboxamide
FormulaC11 H13 N3 O
Molecular Weight203.24
SMILESc1cc2c(cc1C(=O)N)c(c[nH]2)CCN
PubChem1809
Formal Charge0
Total Atoms28
Total Chiral Atoms0
Total Bonds29
Total Aromatic Bonds10

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7X5H_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG AGESGKNTI 
VKQMKITGI VETHFTFKD LHFKMFDVG AQRSERKKW IHCFEGVTA 
IIFCVALSD YDLVLAEDE EMNRMHASM KLFDSICNN KWFTDTSII 
LFLNKKDLF EEKIKKSPL TICYPEYAG SNTYEEAAA YIQCQFEDL 
NKRKDTKEI YTHFTCSTD TKNVQFVFD AVTDVIIKN NLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7X5H_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7X5H_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPFR E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP47898
Sequence
>7X5H_Chain_R
VFGVLILTL LGFLVAATF AWNLLVLAT ILRVRTFHR VPHNLVASM 
AVSDVLVAA LVMPLSLVH ELSGRRWQL GRRLCQLWI ACDVLCCTA 
SIWNVTAIA LDRYWSITR HMEYTLRTR KCVSNVMIA LTWALSAVI 
SLAPLLFGW GETYSEGSE ECQVSREPS YAVFSTVGA FYLPLCVVL 
FVYWKIYKA AKFRVGSRE QKEQRAALM VGILIGVFV LCWIPFFLT 
ELISPLCSC DIPAIWKSI FLWLGYSNS FFNPLIYTA FNKNYNSAF 
KNFF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
gi_5ht7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7UM4AAmine5-Hydroxytryptamine5-HT5AHomo sapiensAS2674723--2.82022-07-2010.1038/s41594-022-00796-6
7UM5AAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-chim(NtGi1-Go)/&β;1/&γ;22.732022-07-2010.1038/s41594-022-00796-6
7UM6AAmine5-Hydroxytryptamine5-HT5AHomo sapiensLisuride-chim(NtGi1-Go)/&β;1/&γ;22.792022-07-2010.1038/s41594-022-00796-6
7UM7AAmine5-Hydroxytryptamine5-HT5AHomo sapiensMethylergometrine-chim(NtGi1-Go)/&β;1/&γ;22.752022-07-2010.1038/s41594-022-00796-6




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Download 7X5H.zip



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