Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7UM5 | A | Amine | 5-Hydroxytryptamine | 5-HT5A | Homo sapiens | 5-CT | - | chim(NtGi1-Go)/Beta1/Gamma2 | 2.73 | 2022-07-20 | 10.1038/s41594-022-00796-6 |
![](/psngpcr/ligands/8K3/8K3_7UM5_L_L_1.png)
A 2D representation of the interactions of 8K3 in 7UM5 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V89 | R:R:V93 | 3.21 | 3 | Yes | No | 7 | 7 | 2 | 2 | R:R:M94 | R:R:V89 | 6.09 | 3 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:V89 | R:R:Y328 | 2.52 | 3 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:D121 | R:R:V93 | 7.3 | 3 | No | No | 8 | 7 | 1 | 2 | R:R:V93 | R:R:Y328 | 5.05 | 3 | No | Yes | 7 | 7 | 2 | 1 | R:R:M94 | R:R:W325 | 4.65 | 3 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:M94 | R:R:Y328 | 7.18 | 3 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:S97 | R:R:Y328 | 2.54 | 0 | No | Yes | 6 | 7 | 2 | 1 | R:R:I118 | R:R:V194 | 3.07 | 0 | No | No | 6 | 4 | 2 | 1 | R:R:D121 | R:R:Y328 | 8.05 | 3 | No | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:D121 | 8.36 | 3 | Yes | No | 0 | 8 | 0 | 1 | R:R:S173 | R:R:V122 | 6.46 | 0 | No | No | 8 | 7 | 2 | 1 | L:L:?1 | R:R:V122 | 11.8 | 3 | Yes | No | 0 | 7 | 0 | 1 | R:R:C125 | R:R:W298 | 2.61 | 3 | No | Yes | 6 | 8 | 1 | 2 | R:R:C125 | R:R:Y328 | 2.69 | 3 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:C125 | 5.59 | 3 | Yes | No | 0 | 6 | 0 | 1 | R:R:S169 | R:R:T126 | 6.4 | 0 | No | No | 8 | 7 | 2 | 1 | R:R:A208 | R:R:T126 | 3.36 | 0 | No | No | 7 | 7 | 2 | 1 | L:L:?1 | R:R:T126 | 3.89 | 3 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:V194 | 2.62 | 3 | Yes | No | 0 | 4 | 0 | 1 | R:R:S204 | R:R:Y200 | 7.63 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:S204 | 10.57 | 3 | Yes | No | 0 | 6 | 0 | 1 | R:R:T205 | R:R:Y210 | 3.75 | 3 | Yes | No | 6 | 5 | 1 | 2 | R:R:F302 | R:R:T205 | 5.19 | 3 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:E305 | R:R:T205 | 2.82 | 3 | Yes | Yes | 7 | 6 | 1 | 1 | R:R:L306 | R:R:T205 | 5.9 | 3 | No | Yes | 5 | 6 | 2 | 1 | L:L:?1 | R:R:T205 | 2.59 | 3 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F209 | R:R:W298 | 6.01 | 3 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F209 | R:R:F302 | 16.08 | 3 | Yes | Yes | 8 | 6 | 2 | 1 | R:R:L306 | R:R:Y210 | 4.69 | 3 | No | No | 5 | 5 | 2 | 2 | R:R:F301 | R:R:W298 | 3.01 | 3 | No | Yes | 7 | 8 | 1 | 2 | R:R:F302 | R:R:W298 | 6.01 | 3 | Yes | Yes | 6 | 8 | 1 | 2 | R:R:F301 | R:R:F302 | 11.79 | 3 | No | Yes | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F301 | 10.72 | 3 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F302 | 6.43 | 3 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:E305 | R:R:K320 | 2.7 | 3 | Yes | No | 7 | 4 | 1 | 2 | L:L:?1 | R:R:E305 | 11.66 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:L324 | R:R:Y328 | 7.03 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:W325 | R:R:Y328 | 3.86 | 3 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:Y328 | 3.09 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:T205 | R:R:V206 | 1.59 | 3 | Yes | No | 6 | 4 | 1 | 2 | R:R:I172 | R:R:S204 | 1.55 | 0 | No | No | 6 | 6 | 2 | 1 | R:R:E305 | R:R:R196 | 1.16 | 3 | Yes | No | 7 | 4 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 7.03 | Average Nodes In Shell | 31.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 43.00 | Average Links Mediated by Hubs In Shell | 36.00 |
| ![](/psngpcr/ligands/8K3/8K3_7UM5_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/8K3/8K3_7UM5_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7X5H | A | Amine | 5-Hydroxytryptamine | 5-HT5A | Homo sapiens | 5-CT | - | Gi1/Beta1/Gamma2 | 3.1 | 2022-09-14 | 10.1038/s41421-022-00412-3 |
![](/psngpcr/ligands/8K3/8K3_7X5H_L_L_1.png)
A 2D representation of the interactions of 8K3 in 7X5H colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D121 | R:R:V93 | 7.3 | 2 | No | No | 8 | 7 | 1 | 2 | R:R:V93 | R:R:Y328 | 3.79 | 2 | No | Yes | 7 | 7 | 2 | 2 | R:R:D121 | R:R:Y328 | 8.05 | 2 | No | Yes | 8 | 7 | 1 | 2 | L:L:?1 | R:R:D121 | 10.75 | 2 | Yes | No | 0 | 8 | 0 | 1 | L:L:?1 | R:R:V122 | 10.49 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:C125 | R:R:W298 | 5.22 | 0 | No | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:C125 | 11.17 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:A208 | R:R:T126 | 3.36 | 0 | No | No | 7 | 7 | 1 | 2 | L:L:?1 | R:R:V194 | 7.86 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:S204 | R:R:Y200 | 8.9 | 0 | No | No | 6 | 7 | 1 | 2 | L:L:?1 | R:R:S204 | 7.93 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:A208 | 4.16 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:F209 | R:R:W298 | 7.02 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F209 | R:R:F302 | 25.72 | 2 | Yes | No | 8 | 6 | 2 | 1 | R:R:F302 | R:R:W298 | 7.02 | 2 | No | Yes | 6 | 8 | 1 | 2 | R:R:E305 | R:R:F301 | 16.32 | 2 | No | Yes | 7 | 7 | 1 | 1 | R:R:F301 | R:R:L324 | 7.31 | 2 | Yes | No | 7 | 5 | 1 | 2 | L:L:?1 | R:R:F301 | 5.36 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F302 | 15 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:E305 | 13.99 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:L324 | R:R:Y328 | 11.72 | 0 | No | Yes | 5 | 7 | 2 | 2 | R:R:S173 | R:R:V122 | 3.23 | 0 | Yes | No | 8 | 7 | 2 | 1 | R:R:F301 | R:R:F323 | 3.22 | 2 | Yes | Yes | 7 | 5 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 9.63 | Average Nodes In Shell | 19.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 23.00 | Average Links Mediated by Hubs In Shell | 20.00 |
| ![](/psngpcr/ligands/8K3/8K3_7X5H_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/8K3/8K3_7X5H_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XTC | A | Amine | 5-Hydroxytryptamine | 5-HT7 | Homo sapiens | 5-CT | - | Gs/Beta1/Gamma2 | 3.2 | 2022-07-27 | 10.1016/j.molcel.2022.05.031 |
![](/psngpcr/ligands/8K3/8K3_7XTC_L_L_1.png)
A 2D representation of the interactions of 8K3 in 7XTC colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D162 | R:R:V134 | 10.22 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:V134 | R:R:Y374 | 3.79 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:I159 | R:R:I233 | 4.42 | 13 | Yes | No | 6 | 4 | 2 | 1 | R:R:C166 | R:R:D162 | 3.11 | 1 | No | Yes | 7 | 7 | 1 | 1 | R:R:D162 | R:R:Y374 | 5.75 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:D162 | 9.55 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:I213 | R:R:V163 | 4.61 | 0 | No | No | 6 | 6 | 2 | 1 | R:R:T214 | R:R:V163 | 3.17 | 0 | No | No | 7 | 6 | 2 | 1 | L:L:?1 | R:R:V163 | 15.73 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:C166 | R:R:W340 | 5.22 | 1 | No | Yes | 7 | 8 | 1 | 1 | L:L:?1 | R:R:C166 | 5.59 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:A247 | R:R:T167 | 5.03 | 0 | No | No | 7 | 7 | 1 | 2 | R:R:I170 | R:R:W340 | 5.87 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:I213 | R:R:S243 | 3.1 | 0 | No | No | 6 | 6 | 2 | 1 | R:R:I233 | R:R:Y239 | 4.84 | 0 | No | Yes | 4 | 7 | 1 | 2 | L:L:?1 | R:R:I233 | 6.28 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:S243 | R:R:Y239 | 6.36 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:S243 | 9.25 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F344 | R:R:T244 | 6.49 | 1 | Yes | No | 7 | 6 | 1 | 2 | L:L:?1 | R:R:A247 | 4.16 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:F248 | R:R:F344 | 23.58 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F344 | R:R:W340 | 4.01 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:G373 | R:R:W340 | 8.44 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:N376 | R:R:W340 | 16.95 | 0 | No | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W340 | 4.01 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F343 | R:R:F344 | 3.22 | 1 | No | Yes | 7 | 7 | 1 | 1 | R:R:F343 | R:R:L370 | 7.31 | 1 | No | No | 7 | 6 | 1 | 2 | L:L:?1 | R:R:F343 | 7.5 | 1 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F344 | 12.86 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:S347 | 9.25 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:L370 | R:R:Y374 | 14.07 | 0 | No | Yes | 6 | 7 | 2 | 2 | L:L:?1 | R:R:T240 | 2.59 | 1 | Yes | No | 0 | 6 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 7.89 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 32.00 | Average Links Mediated by Hubs In Shell | 27.00 |
| ![](/psngpcr/ligands/8K3/8K3_7XTC_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/8K3/8K3_7XTC_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|