Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 9.08875820
2R:R:I43 8.015444
3R:R:L47 4.6425446
4R:R:V61 2.485409
5R:R:F71 8.664518
6R:R:V74 6.3075415
7R:R:H76 5.865419
8R:R:N77 6.0175414
9R:R:D86 6.715459
10R:R:W107 6.66167638
11R:R:R111 6.725474
12R:R:W117 8.79535
13R:R:Y140 5.882508
14R:R:W141 6.6175404
15R:R:Y149 5.24833618
16R:R:R154 10.28418
17R:R:W181 7.896507
18R:R:E190 3.81404
19R:R:Y200 10.84407
20R:R:F209 7.8925428
21R:R:P212 6.3575409
22R:R:Y220 4.375409
23R:R:I291 3.105408
24R:R:W298 6.796528
25R:R:F302 8.44526
26R:R:T304 2.668505
27R:R:W325 4.5825406
28R:R:Y338 5.4875489
29R:R:Y345 7.16667618
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:D121 80.82238.36YesNo008
2R:R:D121 R:R:Y328 88.712810.34NoNo087
3R:R:S97 R:R:Y328 82.26593.82NoNo067
4R:R:S97 R:R:W117 81.09124.94NoYes065
5R:R:H100 R:R:W117 40.35112.7NoYes355
6R:R:H100 R:R:R105 42.54485.64NoNo056
7R:R:E101 R:R:R105 20.5013.49NoNo056
8R:R:E101 R:R:W325 18.67536.54NoYes056
9R:R:L47 R:R:W325 26.19064.56YesYes066
10R:R:I43 R:R:L47 15.25025.71YesYes446
11R:R:R105 R:R:S321 20.3173.95NoNo065
12R:R:S321 R:R:W325 18.69653.71NoYes056
13L:L:?1 R:R:F302 74.76479.64YesYes206
14R:R:F302 R:R:W298 84.33948.02YesYes268
15R:R:N330 R:R:W298 16.48869.04NoYes098
16R:R:C297 R:R:N330 14.712311.02NoNo089
17R:R:C297 R:R:F333 12.92192.79NoNo086
18R:R:F332 R:R:F333 11.11747.5NoNo066
19R:R:I129 R:R:W298 1005.87NoYes088
20R:R:I129 R:R:P212 99.70993.39NoYes089
21R:R:P212 R:R:W130 98.61313.51YesNo096
22R:R:T165 R:R:W130 97.82753.64NoNo066
23R:R:N131 R:R:T165 97.55154.39NoNo076
24R:R:M82 R:R:N131 62.44432.8NoNo097
25R:R:M82 R:R:N334 61.09268.41NoNo099
26R:R:D86 R:R:N334 14.71236.73YesNo099
27R:R:D121 R:R:V93 45.2484.38NoNo087
28R:R:C120 R:R:V93 43.70533.42NoNo057
29R:R:C120 R:R:C124 42.21927.28NoNo056
30R:R:C124 R:R:L88 37.6761.59NoNo066
31R:R:L88 R:R:V84 36.95421.49NoNo066
32R:R:L62 R:R:V84 36.78441.49NoNo076
33R:R:A83 R:R:L62 36.61453.15NoNo097
34R:R:A83 R:R:V61 36.4731.7NoYes099
35R:R:T339 R:R:V61 35.25583.17NoYes079
36R:R:T339 R:R:Y345 35.1783.75NoYes078
37R:R:H76 R:R:Y345 31.35668.71YesYes198
38R:R:N131 R:R:S81 75.57148.94NoNo079
39R:R:I162 R:R:S81 70.39133.1NoNo089
40R:R:I162 R:R:S158 61.41113.1NoNo187
41R:R:S158 R:R:V74 62.45843.23NoYes175
42R:R:P75 R:R:V74 14.48593.53NoYes185
43R:R:R154 R:R:V74 46.8127.85YesYes185
44R:R:W107 R:R:W117 35.227513.12YesYes385
45R:R:E190 R:R:W107 24.89565.45YesYes048
46R:R:E190 R:R:R111 17.42275.82YesYes044
47R:R:N334 R:R:V132 48.2912.96NoNo098
48R:R:V132 R:R:Y338 45.2415.05NoYes089
49R:R:R139 R:R:Y338 15.13696.17NoYes899
50R:R:R139 R:R:Y220 13.64385.14NoYes099
51R:R:L290 R:R:Y338 26.96914.69NoYes089
52R:R:L290 R:R:Y220 13.99763.52NoYes089
53R:R:R154 R:R:Y149 64.59567.2YesYes188
54R:R:W141 R:R:Y149 43.98138.68YesYes048
55R:R:W141 R:R:Y140 31.79534.82YesYes048
56R:R:K222 R:R:Y140 23.60067.17NoYes058
57L:L:?1 R:R:S204 21.9810.57YesNo006
58R:R:S204 R:R:Y200 20.373612.72NoYes067
59R:R:W181 R:R:Y200 12.129410.61YesYes077
60R:R:F209 R:R:I299 16.11356.28YesNo086
61R:R:I291 R:R:Y220 21.01054.84YesYes089
62R:R:K222 R:R:K225 19.55285.75NoNo054
63R:R:K225 R:R:W221 17.38736.96NoNo041
64R:R:W221 R:R:Y224 15.20771.93NoNo016
65R:R:K228 R:R:Y224 11.01838.36NoNo056
66R:R:I337 R:R:L290 12.34175.71NoNo088
67R:R:I299 R:R:P300 12.95733.39NoNo069
68L:L:?1 R:R:E305 13.120116.32YesNo207
69R:R:E305 R:R:F301 25.256516.32NoNo077
70R:R:F301 R:R:F323 22.28433.22NoNo075
71R:R:F323 R:R:P300 12.11524.33NoNo059
72R:R:F323 R:R:T304 30.35882.59NoYes055
73R:R:S308 R:R:T304 12.77333.2NoYes035
74R:R:P309 R:R:S308 10.20453.56NoNo053
75R:R:I315 R:R:T304 10.40973.04NoYes045
76R:R:H76 R:R:P75 35.47524.58YesNo198
77R:R:P75 R:R:R154 21.541312.97NoYes188
78R:R:E305 R:R:F302 13.59423.5NoYes276
79R:R:F209 R:R:W298 18.20114.01YesYes288
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D121 8.36 2 Yes No 0 8 0 1
L:L:?1 R:R:V122 11.8 2 Yes No 0 7 0 1
L:L:?1 R:R:C125 5.59 2 Yes No 0 6 0 1
L:L:?1 R:R:T126 5.19 2 Yes No 0 7 0 1
L:L:?1 R:R:V194 5.24 2 Yes No 0 4 0 1
L:L:?1 R:R:S204 10.57 2 Yes No 0 6 0 1
L:L:?1 R:R:F302 9.64 2 Yes Yes 0 6 0 1
L:L:?1 R:R:E305 16.32 2 Yes No 0 7 0 1
R:R:D121 R:R:V93 4.38 0 No No 8 7 1 2
R:R:I118 R:R:V194 4.61 0 No No 6 4 2 1
R:R:D121 R:R:Y328 10.34 0 No No 8 7 1 2
R:R:V122 R:R:V194 3.21 2 No No 7 4 1 1
R:R:A208 R:R:T126 3.36 0 No No 7 7 2 1
R:R:S204 R:R:Y200 12.72 0 No Yes 6 7 1 2
R:R:F302 R:R:T205 3.89 2 Yes No 6 6 1 2
R:R:F209 R:R:W298 4.01 2 Yes Yes 8 8 2 2
R:R:F209 R:R:F302 17.15 2 Yes Yes 8 6 2 1
R:R:F302 R:R:W298 8.02 2 Yes Yes 6 8 1 2
R:R:E305 R:R:F301 16.32 2 No No 7 7 1 2
R:R:E305 R:R:F302 3.5 2 No Yes 7 6 1 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9W6W_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.1
Number of Linked Nodes 249
Number of Links 263
Number of Hubs 29
Number of Links mediated by Hubs 115
Number of Communities 8
Number of Nodes involved in Communities 39
Number of Links involved in Communities 46
Path Summary
Number Of Nodes in MetaPath 80
Number Of Links MetaPath 79
Number of Shortest Paths 34447
Length Of Smallest Path 3
Average Path Length 15.5288
Length of Longest Path 37
Minimum Path Strength 1.27
Average Path Strength 5.93929
Maximum Path Strength 16.32
Minimum Path Correlation 0.7
Average Path Correlation 0.925115
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 46.1303
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 33.1294
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • tetrapyrrole binding   • heme binding   • electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • metal ion binding   • small molecule binding   • G protein-coupled amine receptor activity   • G protein-coupled serotonin receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • Gi/o-coupled serotonin receptor activity   • neurotransmitter receptor activity   • serotonin receptor activity   • electron transport chain   • metabolic process   • cellular process   • generation of precursor metabolites and energy   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway
Gene OntologyBiological Process• electron transport chain   • metabolic process   • cellular process   • generation of precursor metabolites and energy   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • developmental process   • multicellular organismal process   • head development   • forebrain development   • animal organ development   • brain development   • nervous system development   • pallium development   • multicellular organism development   • central nervous system development   • anatomical structure development   • telencephalon development   • hippocampus development   • limbic system development   • system development   • trans-synaptic signaling   • synaptic signaling   • anterograde trans-synaptic signaling   • cell-cell signaling   • chemical synaptic transmission   • response to lipid   • response to chemical   • response to estradiol   • response to oxygen-containing compound   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • cellular anatomical structure   • periplasmic space   • somatodendritic compartment   • cell body   • perikaryon   • neuronal cell body   • cell periphery   • plasma membrane   • membrane   • postsynaptic specialization membrane   • postsynaptic specialization   • synapse   • synaptic membrane   • postsynapse
Gene OntologyCellular Component• cellular anatomical structure   • periplasmic space   • somatodendritic compartment   • cell body   • perikaryon   • neuronal cell body   • cell periphery   • plasma membrane   • membrane   • postsynaptic specialization membrane   • postsynaptic specialization   • synapse   • synaptic membrane   • postsynapse   • organelle   • postsynaptic membrane   • cell junction   • plasma membrane region   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • cell surface receptor signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • multicellular organismal process   • system process   • relaxation of smooth muscle   • regulation of system process   • regulation of muscle system process   • muscle system process   • relaxation of muscle   • positive regulation of relaxation of smooth muscle   • positive regulation of relaxation of muscle   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of relaxation of smooth muscle   • regulation of relaxation of muscle   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • sperm principal piece   • cilium   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • ciliary basal body   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code8K3
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code8K3
Name3-(2-azanylethyl)-1H-indole-5-carboxamide
Synonyms
Identifier
FormulaC11 H13 N3 O
Molecular Weight203.24
SMILES
PubChem1809
Formal Charge0
Total Atoms28
Total Chiral Atoms0
Total Bonds29
Total Aromatic Bonds10

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP47898
Sequence
>9W6W_nogp_Chain_R
VFGVLILTL LGFLVAATF AWNLLVLAT ILRVRTFHR VPHNLVASM 
AVSDVLVAA LVMPLSLVH ELSGRRWQL GRRLCQLWI ACDVLCCTA 
SIWNVTAIA LDRYWSITR HMEYTLRTR KCVSNVMIA LTWALSAVI 
SLAPLLFGW GETYSEGSE ECQVSREPS YAVFSTVGA FYLPLCVVL 
FVYWKIYKA AKFRVGSRE QKEQRAALM VGILIGVFV LCWIPFFLT 
ELISPLCSC DIPAIWKSI FLWLGYSNS FFNPLIYTA FNKNYNSAF 
KNFF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7UM4AAmine5-Hydroxytryptamine5-HT5AHomo sapiensAS2674723--2.82022-07-20doi.org/10.1038/s41594-022-00796-6
7UM5AAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-chim(NtGi1-Go)/β1/γ22.732022-07-20doi.org/10.1038/s41594-022-00796-6
7UM5 (No Gprot) AAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-2.732022-07-20doi.org/10.1038/s41594-022-00796-6
7UM6AAmine5-Hydroxytryptamine5-HT5AHomo sapiensLisuride-chim(NtGi1-Go)/β1/γ22.792022-07-20doi.org/10.1038/s41594-022-00796-6
7UM6 (No Gprot) AAmine5-Hydroxytryptamine5-HT5AHomo sapiensLisuride-2.792022-07-20doi.org/10.1038/s41594-022-00796-6
7UM7AAmine5-Hydroxytryptamine5-HT5AHomo sapiensMethylergometrine-chim(NtGi1-Go)/β1/γ22.752022-07-20doi.org/10.1038/s41594-022-00796-6
7UM7 (No Gprot) AAmine5-Hydroxytryptamine5-HT5AHomo sapiensMethylergometrine-2.752022-07-20doi.org/10.1038/s41594-022-00796-6
7X5HAAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-Gi1/β1/γ23.12022-09-14doi.org/10.1038/s41421-022-00412-3
7X5H (No Gprot) AAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-3.12022-09-14doi.org/10.1038/s41421-022-00412-3
9W6WAAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-Gi1/β1/γ23.132025-11-2610.1186/s43556-025-00359-3
9W6W (No Gprot) AAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-3.132025-11-2610.1186/s43556-025-00359-3




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Download 9W6W_nogp.zip



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