psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G40	R:R:I43	3.53	No	No	0	3	4
2	R:R:L102	R:R:L44	5.54	No	No	0	5	5
3	R:R:L47	R:R:L98	4.15	No	No	1	6	6
4	R:R:L47	R:R:W325	7.97	No	Yes	1	6	6
5	R:R:M94	R:R:V51	3.04	Yes	No	0	7	6
6	R:R:A53	R:R:F332	4.16	No	Yes	0	4	6
7	R:R:A90	R:R:T54	3.36	No	No	0	7	7
8	R:R:F332	R:R:T54	6.49	Yes	No	0	6	7
9	R:R:F332	R:R:W57	6.01	Yes	No	0	6	8
10	R:R:L336	R:R:W57	4.56	No	No	0	6	8
11	R:R:A83	R:R:N58	4.69	No	No	0	9	9
12	R:R:D86	R:R:N58	13.46	Yes	No	5	9	9
13	R:R:N58	R:R:P335	13.03	No	No	5	9	9
14	R:R:A83	R:R:V61	3.39	No	No	0	9	9
15	R:R:A83	R:R:L62	3.15	No	No	0	9	7
16	R:R:L62	R:R:V84	2.98	No	No	0	7	6
17	R:R:A63	R:R:R67	4.15	No	No	0	5	5
18	R:R:T64	R:R:V68	3.17	Yes	No	0	7	5
19	R:R:F71	R:R:I65	3.77	Yes	No	3	8	7
20	R:R:I65	R:R:Y345	3.63	No	Yes	3	7	8
21	R:R:T70	R:R:V68	3.17	No	No	0	6	5
22	R:R:F71	R:R:T70	5.19	Yes	No	0	8	6
23	R:R:F71	R:R:H76	6.79	Yes	No	3	8	9
24	R:R:F71	R:R:N344	9.67	Yes	No	0	8	7
25	R:R:F71	R:R:Y345	8.25	Yes	Yes	3	8	8
26	R:R:P75	R:R:V74	3.53	No	No	2	8	5
27	R:R:R154	R:R:V74	6.54	Yes	No	2	8	5
28	R:R:K155	R:R:V74	3.04	No	No	0	3	5
29	R:R:P75	R:R:R154	8.65	No	Yes	2	8	8
30	R:R:H76	R:R:Y345	9.8	No	Yes	3	9	8
31	R:R:L78	R:R:N77	5.49	Yes	No	6	8	4
32	R:R:N77	R:R:S158	5.96	No	No	6	4	7
33	R:R:N159	R:R:N77	4.09	No	No	0	3	4
34	R:R:L78	R:R:S158	4.5	Yes	No	6	8	7
35	R:R:I162	R:R:L78	4.28	No	Yes	0	8	8
36	R:R:V79	R:R:Y345	5.05	No	Yes	0	8	8
37	R:R:N131	R:R:S81	5.96	No	No	0	7	9
38	R:R:I162	R:R:S81	6.19	No	No	0	8	9
39	R:R:S81	R:R:W166	3.71	No	No	0	9	9
40	R:R:M82	R:R:N334	5.61	No	No	0	9	9
41	R:R:M82	R:R:Y338	3.59	No	Yes	0	9	9
42	R:R:A127	R:R:S85	3.42	No	No	0	8	8
43	R:R:S128	R:R:S85	4.89	No	No	0	9	8
44	R:R:D86	R:R:S128	4.42	Yes	No	0	9	9
45	R:R:D86	R:R:S331	11.78	Yes	No	0	9	9
46	R:R:D86	R:R:P335	3.22	Yes	No	5	9	9
47	R:R:C124	R:R:L88	4.76	No	No	0	6	6
48	R:R:V89	R:R:V93	3.21	No	Yes	1	7	7
49	R:R:M94	R:R:V89	3.04	Yes	No	0	7	7
50	R:R:L92	R:R:V93	2.98	No	Yes	0	5	7
51	R:R:D121	R:R:V93	4.38	Yes	Yes	1	8	7
52	R:R:V93	R:R:Y328	3.79	Yes	Yes	1	7	7
53	R:R:M94	R:R:Y328	4.79	Yes	Yes	0	7	7
54	R:R:L96	R:R:W117	7.97	No	Yes	0	5	5
55	R:R:S97	R:R:W325	7.41	No	Yes	1	6	6
56	R:R:S97	R:R:Y328	5.09	No	Yes	1	6	7
57	R:R:L98	R:R:W325	4.56	No	Yes	1	6	6
58	R:R:H100	R:R:W107	10.58	No	Yes	1	5	8
59	R:R:H100	R:R:W117	8.46	No	Yes	1	5	5
60	R:R:E191	R:R:H100	16	No	No	1	3	5
61	R:R:E101	R:R:W325	5.45	No	Yes	0	5	6
62	R:R:L109	R:R:W107	6.83	No	Yes	0	6	8
63	R:R:C114	R:R:W107	3.92	No	Yes	0	9	8
64	R:R:W107	R:R:W117	4.69	Yes	Yes	1	8	5
65	R:R:E191	R:R:W107	3.27	No	Yes	1	3	8
66	R:R:Q115	R:R:R111	3.5	No	No	0	6	4
67	R:R:C114	R:R:Q115	6.1	No	No	0	9	6
68	R:R:C114	R:R:C192	7.28	No	No	0	9	9
69	L:L:?1	R:R:W117	9.72	Yes	Yes	1	0	5
70	R:R:I118	R:R:V194	4.61	No	No	0	6	4
71	R:R:C125	R:R:D121	3.11	No	Yes	1	6	8
72	R:R:D121	R:R:Y328	10.34	Yes	Yes	1	8	7
73	L:L:?1	R:R:D121	22.11	Yes	Yes	1	0	8
74	R:R:S173	R:R:V122	3.23	No	No	0	8	7
75	L:L:?1	R:R:V122	8.09	Yes	No	0	0	7
76	R:R:L123	R:R:S169	4.5	No	No	0	5	8
77	R:R:L123	R:R:S173	4.5	No	No	0	5	8
78	L:L:?1	R:R:C125	7.39	Yes	No	1	0	6
79	R:R:S169	R:R:T126	3.2	No	No	0	8	7
80	R:R:A208	R:R:T126	3.36	No	No	0	7	7
81	R:R:A127	R:R:W166	6.48	No	No	0	8	9
82	R:R:I129	R:R:P212	3.39	No	No	0	8	9
83	R:R:I129	R:R:W298	3.52	No	Yes	0	8	8
84	R:R:T133	R:R:W130	4.85	No	Yes	0	6	6
85	R:R:T165	R:R:W130	3.64	No	Yes	0	6	6
86	R:R:L168	R:R:W130	5.69	No	Yes	0	4	6
87	R:R:P212	R:R:W130	8.11	No	Yes	0	9	6
88	R:R:N131	R:R:T165	5.85	No	No	0	7	6
89	R:R:F294	R:R:V132	3.93	No	No	0	9	8
90	R:R:N334	R:R:V132	4.43	No	No	0	9	8
91	R:R:V132	R:R:Y338	3.79	No	Yes	0	8	9
92	R:R:T133	R:R:V215	3.17	No	No	0	6	6
93	R:R:T133	R:R:V216	3.17	No	No	0	6	8
94	R:R:A134	R:R:M161	3.22	No	No	0	7	5
95	R:R:I135	R:R:R139	6.26	No	No	7	9	9
96	R:R:I135	R:R:Y338	3.63	No	Yes	7	9	9
97	R:R:A136	R:R:Y220	4	No	Yes	0	8	9
98	R:R:L137	R:R:W141	6.83	No	Yes	0	6	4
99	R:R:L137	R:R:V215	2.98	No	No	0	6	6
100	R:R:D138	R:R:Y149	8.05	No	Yes	2	9	8
101	R:R:D138	R:R:R154	8.34	No	Yes	2	9	8
102	R:R:R139	R:R:Y338	6.17	No	Yes	7	9	9
103	R:R:W141	R:R:Y140	3.86	Yes	No	0	4	8
104	R:R:V219	R:R:Y140	6.31	No	No	0	6	8
105	R:R:K222	R:R:Y140	9.55	No	No	0	5	8
106	R:R:W141	R:R:Y149	9.65	Yes	Yes	0	4	8
107	R:R:R154	R:R:S142	5.27	Yes	No	0	8	8
108	R:R:R145	R:R:T144	3.88	Yes	No	0	5	6
109	R:R:R154	R:R:Y149	11.32	Yes	Yes	2	8	8
110	R:R:V157	R:R:Y149	3.79	No	Yes	0	6	8
111	R:R:L151	R:R:T150	7.37	No	No	0	4	5
112	R:R:R152	R:R:T153	3.88	No	No	0	5	7
113	R:R:T165	R:R:W166	3.64	No	No	0	6	9
114	R:R:I172	R:R:S204	3.1	No	No	0	6	6
115	R:R:L174	R:R:S173	6.01	No	No	0	4	8
116	R:R:L177	R:R:P176	3.28	No	No	0	6	7
117	R:R:P176	R:R:Y200	13.91	No	No	0	7	7
118	L:L:?1	R:R:V194	4.62	Yes	No	0	0	4
119	R:R:E197	R:R:S195	11.5	No	No	0	6	3
120	R:R:S195	R:R:Y200	8.9	No	No	0	3	7
121	R:R:E305	R:R:R196	4.65	No	No	0	7	4
122	R:R:P309	R:R:R196	5.76	No	No	0	5	4
123	R:R:S204	R:R:Y200	6.36	No	No	0	6	7
124	R:R:A201	R:R:P309	3.74	No	No	0	6	5
125	R:R:L310	R:R:V202	2.98	No	No	0	5	6
126	L:L:?1	R:R:S204	4.66	Yes	No	0	0	6
127	R:R:T205	R:R:Y210	4.99	No	Yes	0	6	5
128	R:R:F302	R:R:T205	5.19	Yes	No	0	6	6
129	R:R:V206	R:R:Y210	3.79	No	Yes	0	4	5
130	R:R:F209	R:R:Y210	4.13	Yes	Yes	0	8	5
131	R:R:F209	R:R:W298	4.01	Yes	Yes	1	8	8
132	R:R:F209	R:R:F302	16.08	Yes	Yes	1	8	6
133	R:R:L303	R:R:Y210	3.52	No	Yes	0	5	5
134	R:R:L306	R:R:Y210	4.69	No	Yes	0	5	5
135	R:R:L211	R:R:P212	3.28	No	No	0	6	9
136	R:R:I291	R:R:L217	4.28	No	No	0	8	4
137	R:R:V287	R:R:Y220	3.79	No	Yes	0	8	9
138	R:R:L290	R:R:Y220	5.86	No	Yes	0	8	9
139	R:R:K222	R:R:W221	5.8	No	No	0	5	1
140	R:R:K225	R:R:W221	5.8	No	No	0	4	1
141	R:R:K228	R:R:Y224	4.78	No	No	0	5	6
142	R:R:A284	R:R:Y224	5.34	No	No	0	7	6
143	R:R:E280	R:R:K228	9.45	No	No	0	7	5
144	R:R:E277	R:R:R276	3.49	No	No	0	4	5
145	R:R:L290	R:R:Y338	8.21	No	Yes	0	8	9
146	R:R:F333	R:R:V293	3.93	No	No	0	6	5
147	R:R:I337	R:R:V293	4.61	Yes	No	0	8	5
148	R:R:I299	R:R:V295	3.07	No	No	0	6	5
149	R:R:C297	R:R:N330	9.45	No	No	0	8	9
150	R:R:F302	R:R:W298	5.01	Yes	Yes	1	6	8
151	R:R:G327	R:R:W298	8.44	No	Yes	0	7	8
152	R:R:N330	R:R:W298	7.91	No	Yes	0	9	8
153	R:R:I299	R:R:P300	3.39	No	No	0	6	9
154	R:R:I299	R:R:L303	4.28	No	No	0	6	5
155	R:R:F323	R:R:P300	8.67	No	No	0	5	9
156	R:R:F301	R:R:F302	3.22	No	Yes	1	7	6
157	L:L:?1	R:R:F301	11.34	Yes	No	1	0	7
158	L:L:?1	R:R:F302	4.73	Yes	Yes	1	0	6
159	R:R:I315	R:R:T304	4.56	No	No	0	4	5
160	L:L:?1	R:R:E305	3.08	Yes	No	0	0	7
161	R:R:C311	R:R:I307	3.27	No	No	0	3	5
162	R:R:I315	R:R:K320	7.27	No	No	0	4	4
163	R:R:P316	R:R:W319	5.4	No	No	0	5	4
164	R:R:L324	R:R:Y328	4.69	No	Yes	0	5	7
165	L:L:?1	R:R:L324	4.3	Yes	No	0	0	5
166	R:R:W325	R:R:Y328	4.82	Yes	Yes	1	6	7
167	R:R:F333	R:R:S329	5.28	No	No	0	6	4
168	R:R:N330	R:R:N334	8.17	No	No	0	9	9
169	R:R:A340	R:R:L336	4.73	No	No	4	6	6
170	R:R:F341	R:R:L336	7.31	No	No	4	6	6
171	R:R:T339	R:R:Y345	9.99	No	Yes	0	7	8
172	R:R:A340	R:R:F341	5.55	No	No	4	6	6
173	R:R:L42	R:R:T45	2.95	No	No	0	4	4
174	R:R:I289	R:R:I337	2.94	No	Yes	0	7	8
175	R:R:I337	R:R:L290	2.85	Yes	No	0	8	8
176	R:R:C156	R:R:R152	2.79	No	No	0	5	5
177	R:R:A91	R:R:F55	2.77	No	No	0	4	6
178	R:R:F55	R:R:V87	2.62	No	No	0	6	7
179	R:R:F323	R:R:T304	2.59	No	No	0	5	5
180	R:R:F341	R:R:I337	2.51	No	Yes	0	6	8
181	R:R:F218	R:R:K222	2.48	No	No	0	4	5
182	R:R:F55	R:R:L59	2.44	No	No	0	6	4
183	R:R:F209	R:R:L213	2.44	Yes	No	0	8	5
184	R:R:F294	R:R:L213	2.44	No	No	0	9	5
185	R:R:I291	R:R:Y220	2.42	No	Yes	0	8	9
186	R:R:Q115	R:R:R112	2.34	No	No	0	6	1
187	R:R:N342	R:R:Y345	2.33	No	Yes	0	8	8
188	R:R:R145	R:R:W141	2	Yes	Yes	0	5	4
189	R:R:A175	R:R:P176	1.87	No	No	0	7	7
190	R:R:G48	R:R:V51	1.84	No	No	0	3	6
191	R:R:G207	R:R:V206	1.84	No	No	0	5	4
192	R:R:P309	R:R:S308	1.78	No	No	0	5	3
193	R:R:G292	R:R:I291	1.76	No	No	0	5	8
194	R:R:P335	R:R:T339	1.75	No	No	0	9	7
195	R:R:C124	R:R:V89	1.71	No	No	1	6	7
196	R:R:C120	R:R:V93	1.71	No	Yes	0	5	7
197	R:R:C124	R:R:V93	1.71	No	Yes	1	6	7
198	R:R:G110	R:R:L109	1.71	No	No	0	7	6
199	R:R:C156	R:R:V160	1.71	No	No	0	5	3
200	R:R:G327	R:R:L326	1.71	No	No	0	7	8
201	R:R:I315	R:R:P316	1.69	No	No	0	4	5
202	R:R:A348	R:R:T64	1.68	No	Yes	0	7	7
203	R:R:M94	R:R:P95	1.68	Yes	No	0	7	9
204	R:R:M147	R:R:P146	1.68	No	No	0	7	8
205	R:R:S103	R:R:V99	1.62	No	No	0	3	5
206	R:R:A226	R:R:I143	1.62	No	No	0	6	9
207	R:R:T153	R:R:V157	1.59	No	No	0	7	6
208	R:R:C297	R:R:L296	1.59	No	No	0	8	5
209	R:R:A80	R:R:L62	1.58	No	No	0	5	7
210	R:R:A134	R:R:L78	1.58	No	Yes	0	7	8
211	R:R:A91	R:R:L92	1.58	No	No	0	4	5
212	R:R:A119	R:R:L174	1.58	No	No	0	6	4
213	R:R:A170	R:R:L123	1.58	No	No	0	4	5
214	R:R:E197	R:R:P198	1.57	No	No	0	6	4
215	R:R:I143	R:R:S142	1.55	No	No	0	9	8
216	R:R:I223	R:R:V219	1.54	No	No	0	9	6
217	R:R:G104	R:R:R105	1.5	No	No	0	4	6
218	R:R:L164	R:R:V160	1.49	No	No	0	3	3
219	R:R:L306	R:R:V202	1.49	No	No	0	5	6
220	R:R:N344	R:R:S347	1.49	No	No	0	7	5
221	R:R:L60	R:R:T64	1.47	No	Yes	0	6	7
222	R:R:P75	R:R:R73	1.44	No	No	0	8	7
223	R:R:P146	R:R:R145	1.44	No	Yes	0	8	5
224	R:R:E197	R:R:S199	1.44	No	No	0	6	3
225	R:R:I43	R:R:L47	1.43	No	No	0	4	6
226	R:R:K343	R:R:N342	1.4	No	No	0	5	8
227	R:R:L102	R:R:L98	1.38	No	No	0	5	6
228	R:R:A317	R:R:R105	1.38	No	No	0	3	6
229	R:R:R67	R:R:T64	1.29	No	Yes	0	5	7
230	R:R:Q278	R:R:Q281	1.28	No	No	0	5	5
231	R:R:E277	R:R:Q281	1.27	No	No	0	4	5
232	R:R:M286	R:R:R282	1.24	No	No	0	8	8
233	R:R:K343	R:R:R282	1.24	No	No	0	5	8
234	R:R:S321	R:R:W325	1.24	No	Yes	0	5	6
235	R:R:F49	R:R:L50	1.22	No	No	0	4	7
236	R:R:F332	R:R:L50	1.22	Yes	No	0	6	7
237	R:R:Q108	R:R:R106	1.17	No	No	0	3	3
238	R:R:E148	R:R:R145	1.16	No	Yes	0	5	5
239	R:R:W221	R:R:Y224	0.96	No	No	0	1	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T64	1.9025	4	0	7
2	R:R:F71	6.734	5	3	8
3	R:R:L78	3.9625	4	6	8
4	R:R:D86	8.22	4	5	9
5	R:R:V93	2.96333	6	1	7
6	R:R:M94	3.1375	4	0	7
7	R:R:W107	5.858	5	1	8
8	R:R:W117	7.71	4	1	5
9	R:R:D121	9.985	4	1	8
10	R:R:W130	5.5725	4	0	6
11	R:R:W141	5.585	4	0	4
12	R:R:R145	2.12	4	0	5
13	R:R:Y149	8.2025	4	2	8
14	R:R:R154	8.024	5	2	8
15	R:R:F209	6.665	4	1	8
16	R:R:Y210	4.224	5	0	5
17	R:R:Y220	4.0175	4	0	9
18	R:R:W298	5.778	5	1	8
19	R:R:F302	6.846	5	1	6
20	R:R:W325	5.24167	6	1	6
21	R:R:Y328	5.58667	6	1	7
22	R:R:F332	4.47	4	0	6
23	R:R:I337	3.2275	4	0	8
24	R:R:Y338	5.078	5	7	9
25	R:R:Y345	6.50833	6	3	8
26	L:L:?1	8.004	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W325	R:R:Y328	25.7015	4.82	Yes	Yes	1	6	7
2	R:R:M94	R:R:Y328	12.3782	4.79	Yes	Yes	0	7	7
3	R:R:F332	R:R:W57	17.2832	6.01	Yes	No	0	6	8
4	R:R:L336	R:R:W57	20.1241	4.56	No	No	0	6	8
5	R:R:F341	R:R:L336	22.907	7.31	No	No	4	6	6
6	R:R:F341	R:R:I337	28.5772	2.51	No	Yes	0	6	8
7	R:R:I337	R:R:L290	42.4107	2.85	Yes	No	0	8	8
8	R:R:L290	R:R:Y338	60.436	8.21	No	Yes	0	8	9
9	R:R:M82	R:R:Y338	26.3335	3.59	No	Yes	0	9	9
10	R:R:M82	R:R:N334	27.3887	5.61	No	No	0	9	9
11	R:R:N330	R:R:N334	55.647	8.17	No	No	0	9	9
12	R:R:N330	R:R:W298	58.1691	7.91	No	Yes	0	9	8
13	R:R:F302	R:R:W298	73.0809	5.01	Yes	Yes	1	6	8
14	L:L:?1	R:R:F302	100	4.73	Yes	Yes	1	0	6
15	L:L:?1	R:R:D121	37.0826	22.11	Yes	Yes	1	0	8
16	R:R:D121	R:R:Y328	21.1039	10.34	Yes	Yes	1	8	7
17	R:R:V132	R:R:Y338	41.3787	3.79	No	Yes	0	8	9
18	R:R:N334	R:R:V132	27.4351	4.43	No	No	0	9	8
19	R:R:F294	R:R:V132	15.5902	3.93	No	No	0	9	8
20	R:R:F294	R:R:L213	16.5642	2.44	No	No	0	9	5
21	R:R:F209	R:R:L213	17.5615	2.44	Yes	No	0	8	5
22	R:R:F209	R:R:F302	21.8344	16.08	Yes	Yes	1	8	6
23	L:L:?1	R:R:L324	22.2808	4.3	Yes	No	0	0	5
24	R:R:L324	R:R:Y328	21.1561	4.69	No	Yes	0	5	7
25	R:R:D86	R:R:S128	35.0128	4.42	Yes	No	0	9	9
26	R:R:S128	R:R:S85	36.1259	4.89	No	No	0	9	8
27	R:R:A127	R:R:S85	37.2275	3.42	No	No	0	8	8
28	R:R:A127	R:R:W166	38.3175	6.48	No	No	0	8	9
29	R:R:T165	R:R:W166	47.3272	3.64	No	No	0	6	9
30	R:R:T165	R:R:W130	58.8532	3.64	No	Yes	0	6	6
31	R:R:P212	R:R:W130	84.2764	8.11	No	Yes	0	9	6
32	R:R:I129	R:R:P212	85.1577	3.39	No	No	0	8	9
33	R:R:I129	R:R:W298	85.5809	3.52	No	Yes	0	8	8
34	R:R:D86	R:R:P335	24.9942	3.22	Yes	No	5	9	9
35	R:R:F71	R:R:Y345	13.503	8.25	Yes	Yes	3	8	8
36	R:R:T339	R:R:Y345	23.2433	9.99	No	Yes	0	7	8
37	R:R:P335	R:R:T339	24.4724	1.75	No	No	0	9	7
38	R:R:T133	R:R:W130	45.5705	4.85	No	Yes	0	6	6
39	R:R:T133	R:R:V215	43.4369	3.17	No	No	0	6	6
40	R:R:L137	R:R:V215	42.3122	2.98	No	No	0	6	6
41	R:R:L137	R:R:W141	41.2164	6.83	No	Yes	0	6	4
42	R:R:W141	R:R:Y149	21.4112	9.65	Yes	Yes	0	4	8
43	R:R:R154	R:R:Y149	10.8186	11.32	Yes	Yes	2	8	8
44	R:R:N131	R:R:T165	10.981	5.85	No	No	0	7	6
45	R:R:I162	R:R:S81	18.176	6.19	No	No	0	8	9
46	R:R:I162	R:R:L78	15.6134	4.28	No	Yes	0	8	8
47	R:R:S81	R:R:W166	11.2651	3.71	No	No	0	9	9
48	L:L:?1	R:R:W117	20.3096	9.72	Yes	Yes	1	0	5
49	R:R:W107	R:R:W117	14.8307	4.69	Yes	Yes	1	8	5
50	L:L:?1	R:R:V122	14.9235	8.09	Yes	No	0	0	7
51	R:R:S173	R:R:V122	13.445	3.23	No	No	0	8	7
52	R:R:L290	R:R:Y220	16.7556	5.86	No	Yes	0	8	9
53	R:R:W141	R:R:Y140	14.8133	3.86	Yes	No	0	4	8
54	R:R:K222	R:R:Y140	10.8882	9.55	No	No	0	5	8
55	L:L:?1	R:R:S204	16.2512	4.66	Yes	No	0	0	6
56	R:R:S204	R:R:Y200	13.445	6.36	No	No	0	6	7
57	R:R:F209	R:R:Y210	19.6313	4.13	Yes	Yes	0	8	5
58	R:R:L303	R:R:Y210	17.3122	3.52	No	Yes	0	5	5
59	R:R:I299	R:R:L303	15.683	4.28	No	No	0	6	5
60	R:R:I299	R:R:P300	12.2043	3.39	No	No	0	6	9
61	R:R:F323	R:R:P300	10.4476	8.67	No	No	0	5	9
62	R:R:D121	R:R:V93	14.8945	4.38	Yes	Yes	1	8	7
63	R:R:F209	R:R:W298	10.7607	4.01	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D121	R:R:V93	4.38	1	Yes	Yes	8	7	1	2
R:R:V93	R:R:Y328	3.79	1	Yes	Yes	7	7	2	2
R:R:L96	R:R:W117	7.97	0	No	Yes	5	5	2	1
R:R:H100	R:R:W107	10.58	1	No	Yes	5	8	2	2
R:R:H100	R:R:W117	8.46	1	No	Yes	5	5	2	1
R:R:W107	R:R:W117	4.69	1	Yes	Yes	8	5	2	1
L:L:?1	R:R:W117	9.72	1	Yes	Yes	0	5	0	1
R:R:I118	R:R:V194	4.61	0	No	No	6	4	2	1
R:R:C125	R:R:D121	3.11	1	No	Yes	6	8	1	1
R:R:D121	R:R:Y328	10.34	1	Yes	Yes	8	7	1	2
L:L:?1	R:R:D121	22.11	1	Yes	Yes	0	8	0	1
R:R:S173	R:R:V122	3.23	0	No	No	8	7	2	1
L:L:?1	R:R:V122	8.09	1	Yes	No	0	7	0	1
L:L:?1	R:R:C125	7.39	1	Yes	No	0	6	0	1
R:R:I172	R:R:S204	3.1	0	No	No	6	6	2	1
L:L:?1	R:R:V194	4.62	1	Yes	No	0	4	0	1
R:R:E305	R:R:R196	4.65	0	No	No	7	4	1	2
R:R:S204	R:R:Y200	6.36	0	No	No	6	7	1	2
L:L:?1	R:R:S204	4.66	1	Yes	No	0	6	0	1
R:R:F302	R:R:T205	5.19	1	Yes	No	6	6	1	2
R:R:F209	R:R:W298	4.01	1	Yes	Yes	8	8	2	2
R:R:F209	R:R:F302	16.08	1	Yes	Yes	8	6	2	1
R:R:F302	R:R:W298	5.01	1	Yes	Yes	6	8	1	2
R:R:F301	R:R:F302	3.22	1	No	Yes	7	6	1	1
L:L:?1	R:R:F301	11.34	1	Yes	No	0	7	0	1
L:L:?1	R:R:F302	4.73	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:E305	3.08	1	Yes	No	0	7	0	1
R:R:L324	R:R:Y328	4.69	0	No	Yes	5	7	1	2
L:L:?1	R:R:L324	4.3	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7UM6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	224
Number of Links	239
Number of Hubs	26
Number of Links mediated by Hubs	108
Number of Communities	7
Number of Nodes involved in Communities	40
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	32816
Length Of Smallest Path	3
Average Path Length	13.8388
Length of Longest Path	31
Minimum Path Strength	1.22
Average Path Strength	5.4376
Maximum Path Strength	16.225
Minimum Path Correlation	0.7
Average Path Correlation	0.917021
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	46.3471
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.5771
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • developmental process • multicellular organismal process • head development • forebrain development • animal organ development • brain development • nervous system development • pallium development • multicellular organism development • central nervous system development • anatomical structure development • telencephalon development • hippocampus development • limbic system development • system development • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • response to lipid • response to chemical • response to estradiol • response to oxygen-containing compound • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • cell periphery • plasma membrane • membrane • postsynaptic specialization membrane • postsynaptic specialization • synapse • synaptic membrane • postsynapse • organelle
Gene Ontology	Cellular Component	• somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • cell periphery • plasma membrane • membrane • postsynaptic specialization membrane • postsynaptic specialization • synapse • synaptic membrane • postsynapse • organelle • postsynaptic membrane • cell junction • plasma membrane region • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	H8G
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	H8G
Name	Lisuride
Synonyms	Lisuride
Identifier
Formula	C20 H26 N4 O
Molecular Weight	338.447
SMILES
PubChem	28864
Formal Charge	0
Total Atoms	51
Total Chiral Atoms	2
Total Bonds	54
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47898
Sequence	>7UM6_nogp_Chain_R G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R T F H R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G R R W Q L G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R P M E Y T L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G E E C Q V S R E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V W R E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C S C D I P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N Y N S A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	10.1038/s41421-022-00412-3
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	10.1038/s41594-022-00796-6
	7UM7	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Methylergometrine	-	chim(NtGi1-Go)/β1/γ2	2.75	2022-07-20	10.1038/s41594-022-00796-6
	7UM7 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Methylergometrine	-		2.75	2022-07-20	10.1038/s41594-022-00796-6
	7UM6	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Lisuride	-	chim(NtGi1-Go)/β1/γ2	2.79	2022-07-20	10.1038/s41594-022-00796-6
	7UM6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Lisuride	-		2.79	2022-07-20	10.1038/s41594-022-00796-6
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	10.1038/s41594-022-00796-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7UM6_nogp.zip

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