psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L102	R:R:L44	5.54	No	No	0	5	5
2	R:R:L47	R:R:L98	5.54	No	No	0	6	6
3	R:R:L47	R:R:W325	11.39	No	No	0	6	6
4	R:R:G48	R:R:V51	3.68	No	No	0	3	6
5	R:R:L50	R:R:S329	4.5	No	No	0	7	4
6	R:R:M94	R:R:V51	6.09	Yes	No	0	7	6
7	R:R:M94	R:R:T54	4.52	Yes	No	0	7	7
8	R:R:F332	R:R:T54	3.89	Yes	No	0	6	7
9	R:R:F55	R:R:L59	10.96	No	No	0	6	4
10	R:R:P335	R:R:W57	9.46	No	No	0	9	8
11	R:R:L336	R:R:W57	7.97	No	No	0	6	8
12	R:R:T339	R:R:W57	3.64	Yes	No	0	7	8
13	R:R:D86	R:R:N58	10.77	Yes	No	0	9	9
14	R:R:N58	R:R:P335	4.89	No	No	0	9	9
15	R:R:F349	R:R:L60	6.09	No	No	0	8	6
16	R:R:T339	R:R:V61	6.35	Yes	No	0	7	9
17	R:R:F71	R:R:T64	7.78	Yes	No	0	8	7
18	R:R:F349	R:R:T64	3.89	No	No	0	8	7
19	R:R:H76	R:R:I65	3.98	Yes	No	3	9	7
20	R:R:I65	R:R:Y345	3.63	No	Yes	3	7	8
21	R:R:F352	R:R:R67	7.48	No	No	0	6	5
22	R:R:F71	R:R:V68	7.87	Yes	No	0	8	5
23	R:R:F71	R:R:H76	14.71	Yes	Yes	3	8	9
24	R:R:F71	R:R:Y345	7.22	Yes	Yes	3	8	8
25	R:R:P75	R:R:R73	4.32	No	No	0	8	7
26	R:R:H76	R:R:R73	10.16	Yes	No	0	9	7
27	R:R:R154	R:R:V74	5.23	Yes	No	0	8	5
28	R:R:K155	R:R:V74	10.62	No	No	0	3	5
29	R:R:P75	R:R:R154	8.65	No	Yes	0	8	8
30	R:R:H76	R:R:Y345	10.89	Yes	Yes	3	9	8
31	R:R:L78	R:R:N77	5.49	Yes	No	2	8	4
32	R:R:N77	R:R:S158	10.43	No	No	2	4	7
33	R:R:I162	R:R:N77	5.66	No	No	2	8	4
34	R:R:I135	R:R:L78	5.71	Yes	Yes	2	9	8
35	R:R:D138	R:R:L78	4.07	No	Yes	2	9	8
36	R:R:L78	R:R:S158	7.51	Yes	No	2	8	7
37	R:R:I162	R:R:L78	5.71	No	Yes	2	8	8
38	R:R:V79	R:R:Y345	10.09	No	Yes	0	8	8
39	R:R:N131	R:R:S81	8.94	No	No	0	7	9
40	R:R:I162	R:R:S81	4.64	No	No	0	8	9
41	R:R:S81	R:R:W166	6.18	No	Yes	0	9	9
42	R:R:D86	R:R:M82	5.54	Yes	Yes	2	9	9
43	R:R:I135	R:R:M82	4.37	Yes	Yes	2	9	9
44	R:R:M82	R:R:N334	4.21	Yes	Yes	2	9	9
45	R:R:M82	R:R:Y338	4.79	Yes	Yes	2	9	9
46	R:R:N131	R:R:S85	4.47	No	No	0	7	8
47	R:R:S85	R:R:W166	6.18	No	Yes	0	8	9
48	R:R:D86	R:R:S331	8.83	Yes	No	0	9	9
49	R:R:D86	R:R:N334	4.04	Yes	Yes	2	9	9
50	R:R:C124	R:R:L88	4.76	No	No	0	6	6
51	R:R:S331	R:R:V89	6.46	No	No	0	9	7
52	R:R:D121	R:R:V93	7.3	No	No	1	8	7
53	R:R:V93	R:R:Y328	3.79	No	Yes	1	7	7
54	R:R:M94	R:R:Y328	7.18	Yes	Yes	0	7	7
55	R:R:L96	R:R:W117	10.25	No	Yes	0	5	5
56	R:R:S97	R:R:W117	4.94	No	Yes	1	6	5
57	R:R:S97	R:R:W325	3.71	No	No	1	6	6
58	R:R:S97	R:R:Y328	8.9	No	Yes	1	6	7
59	R:R:L102	R:R:L98	6.92	No	No	0	5	6
60	R:R:E101	R:R:H100	6.15	No	No	0	5	5
61	R:R:H100	R:R:R105	10.16	No	No	0	5	6
62	R:R:H100	R:R:W107	6.35	No	Yes	0	5	8
63	R:R:E101	R:R:S321	7.19	No	No	0	5	5
64	R:R:E190	R:R:R106	9.3	No	No	0	4	3
65	R:R:L109	R:R:W107	15.94	No	Yes	0	6	8
66	R:R:C114	R:R:W107	9.14	No	Yes	1	9	8
67	R:R:W107	R:R:W117	7.5	Yes	Yes	1	8	5
68	R:R:C192	R:R:W107	23.51	Yes	Yes	1	9	8
69	R:R:G110	R:R:L113	5.13	No	No	0	7	5
70	R:R:R111	R:R:R112	6.4	No	No	4	4	1
71	R:R:Q115	R:R:R111	14.02	Yes	No	4	6	4
72	R:R:R111	R:R:T184	3.88	No	No	0	4	4
73	R:R:Q115	R:R:R112	4.67	Yes	No	4	6	1
74	R:R:C114	R:R:C192	7.28	No	Yes	1	9	9
75	R:R:L177	R:R:Q115	5.32	No	Yes	0	6	6
76	R:R:E183	R:R:Q115	3.82	No	Yes	0	4	6
77	R:R:C192	R:R:W117	3.92	Yes	Yes	1	9	5
78	R:R:D121	R:R:Y328	8.05	No	Yes	1	8	7
79	L:L:?1	R:R:D121	10.75	Yes	No	1	0	8
80	L:L:?1	R:R:V122	10.49	Yes	No	0	0	7
81	R:R:L123	R:R:S173	6.01	No	Yes	0	5	8
82	R:R:C125	R:R:W298	5.22	No	Yes	0	6	8
83	L:L:?1	R:R:C125	11.17	Yes	No	0	0	6
84	R:R:S169	R:R:T126	6.4	No	No	0	8	7
85	R:R:A127	R:R:W166	6.48	No	Yes	0	8	9
86	R:R:I129	R:R:W298	14.09	No	Yes	0	8	8
87	R:R:T133	R:R:W130	3.64	No	Yes	5	6	6
88	R:R:T165	R:R:W130	4.85	No	Yes	0	6	6
89	R:R:L168	R:R:W130	7.97	No	Yes	0	4	6
90	R:R:P212	R:R:W130	16.21	No	Yes	5	9	6
91	R:R:N131	R:R:T165	4.39	No	No	0	7	6
92	R:R:N334	R:R:V132	4.43	Yes	No	0	9	8
93	R:R:V132	R:R:Y338	7.57	No	Yes	0	8	9
94	R:R:P212	R:R:T133	6.99	No	No	5	9	6
95	R:R:T133	R:R:V216	4.76	No	No	0	6	8
96	R:R:A134	R:R:M161	6.44	No	No	0	7	5
97	R:R:I135	R:R:R139	5.01	Yes	No	0	9	9
98	R:R:I135	R:R:Y338	8.46	Yes	Yes	2	9	9
99	R:R:A136	R:R:Y220	4	No	Yes	0	8	9
100	R:R:L137	R:R:W141	5.69	No	Yes	0	6	4
101	R:R:L137	R:R:V215	4.47	No	No	0	6	6
102	R:R:D138	R:R:Y149	9.2	No	Yes	2	9	8
103	R:R:D138	R:R:R154	13.1	No	Yes	2	9	8
104	R:R:W141	R:R:Y140	9.65	Yes	Yes	0	4	8
105	R:R:T144	R:R:Y140	11.24	No	Yes	0	6	8
106	R:R:V219	R:R:Y140	6.31	No	Yes	0	6	8
107	R:R:K222	R:R:Y140	3.58	No	Yes	0	5	8
108	R:R:I223	R:R:Y140	3.63	No	Yes	0	9	8
109	R:R:R145	R:R:W141	11	No	Yes	0	5	4
110	R:R:W141	R:R:Y149	12.54	Yes	Yes	0	4	8
111	R:R:R154	R:R:S142	5.27	Yes	No	0	8	8
112	R:R:I143	R:R:I223	5.89	No	No	0	9	9
113	R:R:H146	R:R:M147	3.94	No	No	0	8	7
114	R:R:E148	R:R:M147	5.41	No	No	0	5	7
115	R:R:R154	R:R:Y149	12.35	Yes	Yes	2	8	8
116	R:R:V157	R:R:Y149	8.83	No	Yes	0	6	8
117	R:R:K155	R:R:N159	8.39	No	No	0	3	3
118	R:R:P176	R:R:S195	5.34	No	No	6	7	3
119	R:R:P176	R:R:Y200	16.69	No	No	6	7	7
120	R:R:G182	R:R:W181	5.63	No	No	0	5	7
121	R:R:E183	R:R:S195	5.75	No	No	0	4	3
122	R:R:S189	R:R:T184	6.4	No	No	0	3	4
123	R:R:S186	R:R:Y185	3.82	No	No	0	2	4
124	R:R:E187	R:R:Y185	19.08	No	No	0	2	4
125	R:R:E191	R:R:Y185	10.1	No	No	0	3	4
126	R:R:E190	R:R:E191	12.69	No	No	0	4	3
127	R:R:Q193	R:R:R196	12.85	No	No	0	4	4
128	L:L:?1	R:R:V194	7.86	Yes	No	0	0	4
129	R:R:S195	R:R:Y200	3.82	No	No	6	3	7
130	R:R:R196	R:R:S308	5.27	No	No	0	4	3
131	R:R:E197	R:R:P198	11	Yes	No	0	6	4
132	R:R:E197	R:R:S199	10.06	Yes	No	0	6	3
133	R:R:P198	R:R:P309	3.9	No	No	0	4	5
134	R:R:S204	R:R:Y200	8.9	No	No	0	6	7
135	R:R:A201	R:R:P309	3.74	No	No	0	6	5
136	L:L:?1	R:R:S204	7.93	Yes	No	0	0	6
137	R:R:T205	R:R:Y210	4.99	No	No	7	6	5
138	R:R:L306	R:R:T205	7.37	No	No	7	5	6
139	L:L:?1	R:R:A208	4.16	Yes	No	0	0	7
140	R:R:F209	R:R:L213	14.61	Yes	No	1	8	5
141	R:R:F209	R:R:F294	7.5	Yes	No	1	8	9
142	R:R:F209	R:R:W298	7.02	Yes	Yes	1	8	8
143	R:R:F209	R:R:F302	25.72	Yes	No	1	8	6
144	R:R:L306	R:R:Y210	5.86	No	No	7	5	5
145	R:R:F294	R:R:L213	3.65	No	No	1	9	5
146	R:R:F218	R:R:K222	9.93	No	No	0	4	5
147	R:R:L290	R:R:Y220	12.89	No	Yes	0	8	9
148	R:R:I291	R:R:Y220	3.63	No	Yes	0	8	9
149	R:R:E280	R:R:Y224	4.49	No	No	0	7	6
150	R:R:A284	R:R:Y224	4	No	No	0	7	6
151	R:R:V287	R:R:Y224	5.05	No	No	0	8	6
152	R:R:E280	R:R:K228	13.5	No	No	0	7	5
153	R:R:F229	R:R:R230	5.34	No	No	0	5	7
154	R:R:F229	R:R:S233	7.93	No	No	0	5	5
155	R:R:K279	R:R:V231	9.11	No	No	0	5	5
156	R:R:Q278	R:R:R276	9.35	No	No	0	5	5
157	R:R:E277	R:R:Q278	3.82	No	No	0	4	5
158	R:R:M286	R:R:R282	3.72	No	No	0	8	8
159	R:R:F341	R:R:M286	6.22	No	No	0	6	8
160	R:R:I337	R:R:L290	4.28	No	No	0	8	8
161	R:R:L290	R:R:Y338	4.69	No	Yes	0	8	9
162	R:R:F333	R:R:V293	3.93	No	No	0	6	5
163	R:R:F294	R:R:W298	4.01	No	Yes	1	9	8
164	R:R:I299	R:R:V295	4.61	No	No	0	6	5
165	R:R:F302	R:R:W298	7.02	No	Yes	1	6	8
166	R:R:G327	R:R:W298	8.44	No	Yes	0	7	8
167	R:R:N330	R:R:W298	14.69	No	Yes	0	9	8
168	R:R:I299	R:R:P300	6.77	No	No	0	6	9
169	R:R:I299	R:R:L303	4.28	No	No	0	6	5
170	R:R:F323	R:R:P300	4.33	Yes	No	0	5	9
171	R:R:E305	R:R:F301	16.32	No	Yes	1	7	7
172	R:R:F301	R:R:L324	7.31	Yes	No	0	7	5
173	L:L:?1	R:R:F301	5.36	Yes	Yes	1	0	7
174	L:L:?1	R:R:F302	15	Yes	No	1	0	6
175	R:R:I315	R:R:T304	6.08	No	No	8	4	5
176	R:R:K320	R:R:T304	4.5	No	No	8	4	5
177	R:R:F323	R:R:T304	10.38	Yes	No	0	5	5
178	L:L:?1	R:R:E305	13.99	Yes	No	1	0	7
179	R:R:C311	R:R:I307	4.91	No	No	0	3	5
180	R:R:K320	R:R:S308	4.59	No	No	0	4	3
181	R:R:C311	R:R:C313	7.28	No	No	0	3	1
182	R:R:I315	R:R:P316	5.08	No	No	0	4	5
183	R:R:I315	R:R:K320	7.27	No	No	8	4	4
184	R:R:P316	R:R:W319	10.81	No	No	0	5	4
185	R:R:F323	R:R:W319	4.01	Yes	No	0	5	4
186	R:R:L324	R:R:Y328	11.72	No	Yes	0	5	7
187	R:R:W325	R:R:Y328	9.65	No	Yes	1	6	7
188	R:R:N330	R:R:N334	12.26	No	Yes	0	9	9
189	R:R:F332	R:R:F333	5.36	Yes	No	0	6	6
190	R:R:T339	R:R:Y345	13.73	Yes	Yes	0	7	8
191	R:R:F349	R:R:T339	5.19	No	Yes	0	8	7
192	R:R:N342	R:R:N344	5.45	No	No	3	8	7
193	R:R:N342	R:R:Y345	13.96	No	Yes	3	8	8
194	R:R:N346	R:R:S347	4.47	No	No	0	9	5
195	R:R:K350	R:R:N346	4.2	No	No	0	7	9
196	R:R:P309	R:R:S308	3.56	No	No	0	5	3
197	R:R:L303	R:R:Y210	3.52	No	No	0	5	5
198	R:R:I318	R:R:W319	3.52	No	No	0	1	4
199	R:R:C124	R:R:V89	3.42	No	No	0	6	7
200	R:R:C124	R:R:V93	3.42	No	No	0	6	7
201	R:R:A127	R:R:S169	3.42	No	No	0	8	8
202	R:R:L211	R:R:W130	3.42	No	Yes	0	6	6
203	R:R:A83	R:R:V61	3.39	No	No	0	9	9
204	R:R:A90	R:R:T54	3.36	No	No	0	7	7
205	R:R:C114	R:R:I118	3.27	No	No	1	9	6
206	R:R:C192	R:R:I118	3.27	Yes	No	1	9	6
207	R:R:E197	R:R:G180	3.27	Yes	No	0	6	6
208	R:R:S173	R:R:V122	3.23	Yes	No	0	8	7
209	R:R:F301	R:R:F323	3.22	Yes	Yes	0	7	5
210	R:R:T70	R:R:V68	3.17	No	No	0	6	5
211	R:R:C120	R:R:L116	3.17	No	No	0	5	4
212	R:R:C297	R:R:N330	3.15	No	No	0	8	9
213	R:R:A340	R:R:L336	3.15	No	No	0	6	6
214	R:R:I172	R:R:T126	3.04	No	No	0	6	7
215	R:R:F179	R:R:G180	3.01	No	No	0	4	6
216	R:R:L174	R:R:S173	3	No	Yes	0	4	8
217	R:R:L59	R:R:V87	2.98	No	No	0	4	7
218	R:R:L62	R:R:V84	2.98	No	No	0	7	6
219	R:R:L164	R:R:V160	2.98	No	No	0	3	3
220	R:R:L306	R:R:V202	2.98	No	No	0	5	6
221	R:R:N58	R:R:V87	2.96	No	No	0	9	7
222	R:R:L42	R:R:T45	2.95	No	No	0	4	4
223	R:R:Q108	R:R:S103	2.89	No	No	0	3	3
224	R:R:K225	R:R:K228	2.87	No	No	0	4	5
225	R:R:I291	R:R:L217	2.85	No	No	0	8	4
226	R:R:I307	R:R:L303	2.85	No	No	0	5	5
227	R:R:L137	R:R:M161	2.83	No	No	0	6	5
228	R:R:A53	R:R:F332	2.77	No	Yes	0	4	6
229	R:R:A348	R:R:F71	2.77	No	Yes	0	7	8
230	R:R:A340	R:R:F341	2.77	No	No	0	6	6
231	R:R:V287	R:R:Y220	2.52	No	Yes	0	8	9
232	R:R:F39	R:R:I43	2.51	No	No	0	2	4
233	R:R:V84	R:R:W166	2.45	No	Yes	0	6	9
234	R:R:F332	R:R:L50	2.44	Yes	No	0	6	7
235	R:R:F352	R:R:L60	2.44	No	No	0	6	6
236	R:R:F353	R:R:L60	2.44	No	No	0	7	6
237	R:R:E148	R:R:R145	2.33	No	No	0	5	5
238	R:R:K225	R:R:W221	2.32	No	No	0	4	1
239	R:R:E197	R:R:W181	2.18	Yes	No	0	6	7
240	R:R:A175	R:R:P176	1.87	No	No	0	7	7
241	R:R:G104	R:R:S103	1.86	No	No	0	4	3
242	R:R:G188	R:R:S189	1.86	No	No	0	4	3
243	R:R:G207	R:R:V206	1.84	No	No	0	5	4
244	R:R:G288	R:R:V287	1.84	No	No	0	6	8
245	R:R:G207	R:R:I172	1.76	No	No	0	5	6
246	R:R:G110	R:R:L109	1.71	No	No	0	7	6
247	R:R:A170	R:R:S173	1.71	No	Yes	0	4	8
248	R:R:G327	R:R:L326	1.71	No	No	0	7	8
249	R:R:M94	R:R:P95	1.68	Yes	No	0	7	9
250	R:R:L310	R:R:P198	1.64	No	No	0	5	4
251	R:R:S128	R:R:S85	1.63	No	No	0	9	8
252	R:R:A80	R:R:I65	1.62	No	No	0	5	7
253	R:R:A226	R:R:I143	1.62	No	No	0	6	9
254	R:R:T45	R:R:V41	1.59	No	No	0	4	6
255	R:R:C120	R:R:L92	1.59	No	No	0	5	5
256	R:R:T153	R:R:V157	1.59	No	No	0	7	6
257	R:R:A91	R:R:L92	1.58	No	No	0	4	5
258	R:R:A119	R:R:L177	1.58	No	No	0	6	6
259	R:R:T150	R:R:T153	1.57	No	No	0	5	7
260	R:R:I289	R:R:V293	1.54	No	No	0	7	5
261	R:R:L46	R:R:T45	1.47	No	No	0	5	4
262	R:R:I43	R:R:L47	1.43	No	No	0	4	6
263	R:R:I322	R:R:L326	1.43	No	No	0	3	8
264	R:R:L285	R:R:M286	1.41	No	No	0	6	8
265	R:R:K343	R:R:N342	1.4	No	No	3	5	8
266	R:R:K343	R:R:N344	1.4	No	No	3	5	7
267	R:R:K343	R:R:N346	1.4	No	No	0	5	9
268	R:R:A317	R:R:R105	1.38	No	No	0	3	6
269	R:R:L113	R:R:L116	1.38	No	No	0	5	4
270	R:R:L177	R:R:L178	1.38	No	No	0	6	5
271	R:R:L109	R:R:Q108	1.33	No	No	0	6	3
272	R:R:R106	R:R:S103	1.32	No	No	0	3	3
273	R:R:R276	R:R:V231	1.31	No	No	0	5	5
274	R:R:F203	R:R:I172	1.26	No	No	0	4	6
275	R:R:F39	R:R:L42	1.22	No	No	0	2	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F71	8.07	5	3	8
2	R:R:H76	9.935	4	3	9
3	R:R:L78	5.698	5	2	8
4	R:R:M82	4.7275	4	2	9
5	R:R:D86	7.295	4	2	9
6	R:R:M94	4.8675	4	0	7
7	R:R:W107	12.488	5	1	8
8	R:R:Q115	6.9575	4	4	6
9	R:R:W117	6.6525	4	1	5
10	R:R:W130	7.218	5	5	6
11	R:R:I135	5.8875	4	2	9
12	R:R:Y140	6.882	5	0	8
13	R:R:W141	9.72	4	0	4
14	R:R:Y149	10.73	4	2	8
15	R:R:R154	8.92	5	2	8
16	R:R:W166	5.3225	4	0	9
17	R:R:S173	3.4875	4	0	8
18	R:R:C192	9.495	4	1	9
19	R:R:E197	6.6275	4	0	6
20	R:R:F209	13.7125	4	1	8
21	R:R:Y220	5.76	4	0	9
22	R:R:W298	8.64143	7	1	8
23	R:R:F301	8.0525	4	1	7
24	R:R:F323	5.485	4	0	5
25	R:R:Y328	8.215	6	1	7
26	R:R:F332	3.615	4	0	6
27	R:R:N334	6.235	4	2	9
28	R:R:Y338	6.3775	4	2	9
29	R:R:T339	7.2275	4	0	7
30	R:R:Y345	9.92	6	3	8
31	L:L:?1	9.63444	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L47	R:R:W325	14.5025	11.39	No	No	0	6	6
2	R:R:M94	R:R:Y328	19.0188	7.18	Yes	Yes	0	7	7
3	R:R:W325	R:R:Y328	14.0467	9.65	No	Yes	1	6	7
4	R:R:M94	R:R:T54	13.3809	4.52	Yes	No	0	7	7
5	R:R:F332	R:R:T54	10.49	3.89	Yes	No	0	6	7
6	R:R:D86	R:R:N58	48.2217	10.77	Yes	No	0	9	9
7	R:R:D86	R:R:S331	41.1324	8.83	Yes	No	0	9	9
8	R:R:S331	R:R:V89	41.2583	6.46	No	No	0	9	7
9	R:R:C124	R:R:V89	41.4083	3.42	No	No	0	6	7
10	R:R:C124	R:R:V93	41.9361	3.42	No	No	0	6	7
11	R:R:V93	R:R:Y328	39.483	3.79	No	Yes	1	7	7
12	R:R:N58	R:R:P335	42.7518	4.89	No	No	0	9	9
13	R:R:P335	R:R:W57	41.3903	9.46	No	No	0	9	8
14	R:R:L336	R:R:W57	10.406	7.97	No	No	0	6	8
15	R:R:T339	R:R:W57	33.4793	3.64	Yes	No	0	7	8
16	R:R:F349	R:R:T339	10.3101	5.19	No	Yes	0	8	7
17	R:R:T339	R:R:Y345	23.8529	13.73	Yes	Yes	0	7	8
18	R:R:D86	R:R:M82	34.8048	5.54	Yes	Yes	2	9	9
19	R:R:I135	R:R:M82	71.2169	4.37	Yes	Yes	2	9	9
20	R:R:I135	R:R:L78	75.4153	5.71	Yes	Yes	2	9	8
21	R:R:D138	R:R:L78	47.358	4.07	No	Yes	2	9	8
22	R:R:D138	R:R:R154	15.906	13.1	No	Yes	2	9	8
23	R:R:P75	R:R:R154	14.2806	8.65	No	Yes	0	8	8
24	R:R:H76	R:R:R73	11.9774	10.16	Yes	No	0	9	7
25	R:R:P75	R:R:R73	12.9551	4.32	No	No	0	8	7
26	R:R:I162	R:R:L78	41.8821	5.71	No	Yes	2	8	8
27	R:R:I162	R:R:S81	40.5506	4.64	No	No	0	8	9
28	R:R:N131	R:R:S81	18.1671	8.94	No	No	0	7	9
29	R:R:S81	R:R:W166	21.7058	6.18	No	Yes	0	9	9
30	R:R:D86	R:R:N334	28.7651	4.04	Yes	Yes	2	9	9
31	R:R:D121	R:R:Y328	16.0559	8.05	No	Yes	1	8	7
32	L:L:?1	R:R:D121	19.2887	10.75	Yes	No	1	0	8
33	L:L:?1	R:R:C125	50.4888	11.17	Yes	No	0	0	6
34	R:R:C125	R:R:W298	50.6328	5.22	No	Yes	0	6	8
35	R:R:N330	R:R:W298	100	14.69	No	Yes	0	9	8
36	R:R:N330	R:R:N334	98.7405	12.26	No	Yes	0	9	9
37	L:L:?1	R:R:F302	52.57	15	Yes	No	1	0	6
38	R:R:F302	R:R:W298	50.6148	7.02	No	Yes	1	6	8
39	R:R:M82	R:R:Y338	19.9484	4.79	Yes	Yes	2	9	9
40	R:R:S97	R:R:W117	37.7557	4.94	No	Yes	1	6	5
41	R:R:W107	R:R:W117	31.4341	7.5	Yes	Yes	1	8	5
42	R:R:Q108	R:R:S103	11.9415	2.89	No	No	0	3	3
43	R:R:L109	R:R:Q108	13.3809	1.33	No	No	0	6	3
44	R:R:L109	R:R:W107	23.1212	15.94	No	Yes	0	6	8
45	L:L:?1	R:R:S204	33.6172	7.93	Yes	No	0	0	6
46	R:R:S204	R:R:Y200	31.4281	8.9	No	No	0	6	7
47	R:R:S195	R:R:Y200	24.6566	3.82	No	No	6	3	7
48	R:R:E183	R:R:S195	22.5454	5.75	No	No	0	4	3
49	R:R:E183	R:R:Q115	20.4882	3.82	No	Yes	0	4	6
50	L:L:?1	R:R:V122	11.6596	10.49	Yes	No	0	0	7
51	R:R:A127	R:R:W166	13.261	6.48	No	Yes	0	8	9
52	R:R:A127	R:R:S169	11.4017	3.42	No	No	0	8	8
53	R:R:N131	R:R:T165	13.3449	4.39	No	No	0	7	6
54	R:R:T165	R:R:W130	11.4736	4.85	No	Yes	0	6	6
55	R:R:N334	R:R:V132	13.5069	4.43	Yes	No	0	9	8
56	R:R:W141	R:R:Y149	29.1309	12.54	Yes	Yes	0	4	8
57	R:R:D138	R:R:Y149	30.3305	9.2	No	Yes	2	9	8
58	R:R:L290	R:R:Y220	30.0306	12.89	No	Yes	0	8	9
59	R:R:L290	R:R:Y338	34.7808	4.69	No	Yes	0	8	9
60	R:R:W141	R:R:Y140	14.0047	9.65	Yes	Yes	0	4	8
61	R:R:E197	R:R:P198	14.2086	11	Yes	No	0	6	4
62	R:R:P198	R:R:P309	18.8508	3.9	No	No	0	4	5
63	R:R:P309	R:R:S308	23.4451	3.56	No	No	0	5	3
64	R:R:K320	R:R:S308	29.9346	4.59	No	No	0	4	3
65	R:R:K320	R:R:T304	31.8539	4.5	No	No	8	4	5
66	R:R:F323	R:R:T304	36.3462	10.38	Yes	No	0	5	5
67	R:R:F301	R:R:F323	68.1221	3.22	Yes	Yes	0	7	5
68	R:R:F301	R:R:L324	13.159	7.31	Yes	No	0	7	5
69	R:R:L324	R:R:Y328	12.6372	11.72	No	Yes	0	5	7
70	R:R:F323	R:R:P300	25.5923	4.33	Yes	No	0	5	9
71	R:R:I299	R:R:P300	23.3251	6.77	No	No	0	6	9
72	R:R:I299	R:R:L303	18.7549	4.28	No	No	0	6	5
73	R:R:E280	R:R:Y224	10.1841	4.49	No	No	0	7	6
74	R:R:V287	R:R:Y224	15.1023	5.05	No	No	0	8	6
75	R:R:V287	R:R:Y220	20.2003	2.52	No	Yes	0	8	9
76	R:R:N342	R:R:Y345	10.61	13.96	No	Yes	3	8	8
77	R:R:S97	R:R:Y328	37.0839	8.9	No	Yes	1	6	7
78	L:L:?1	R:R:F301	59.8213	5.36	Yes	Yes	1	0	7
79	R:R:V132	R:R:Y338	11.9115	7.57	No	Yes	0	8	9
80	R:R:M82	R:R:N334	57.3142	4.21	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D121	R:R:V93	7.3	1	No	No	8	7	1	2
R:R:V93	R:R:Y328	3.79	1	No	Yes	7	7	2	2
R:R:D121	R:R:Y328	8.05	1	No	Yes	8	7	1	2
L:L:?1	R:R:D121	10.75	1	Yes	No	0	8	0	1
L:L:?1	R:R:V122	10.49	1	Yes	No	0	7	0	1
R:R:C125	R:R:W298	5.22	0	No	Yes	6	8	1	2
L:L:?1	R:R:C125	11.17	1	Yes	No	0	6	0	1
L:L:?1	R:R:V194	7.86	1	Yes	No	0	4	0	1
R:R:S204	R:R:Y200	8.9	0	No	No	6	7	1	2
L:L:?1	R:R:S204	7.93	1	Yes	No	0	6	0	1
L:L:?1	R:R:A208	4.16	1	Yes	No	0	7	0	1
R:R:F209	R:R:W298	7.02	1	Yes	Yes	8	8	2	2
R:R:F209	R:R:F302	25.72	1	Yes	No	8	6	2	1
R:R:F302	R:R:W298	7.02	1	No	Yes	6	8	1	2
R:R:E305	R:R:F301	16.32	1	No	Yes	7	7	1	1
R:R:F301	R:R:L324	7.31	1	Yes	No	7	5	1	2
L:L:?1	R:R:F301	5.36	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F302	15	1	Yes	No	0	6	0	1
L:L:?1	R:R:E305	13.99	1	Yes	No	0	7	0	1
R:R:L324	R:R:Y328	11.72	0	No	Yes	5	7	2	2
R:R:S173	R:R:V122	3.23	0	Yes	No	8	7	2	1
R:R:F301	R:R:F323	3.22	1	Yes	Yes	7	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7X5H_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.58
Number of Linked Nodes	249
Number of Links	275
Number of Hubs	31
Number of Links mediated by Hubs	121
Number of Communities	8
Number of Nodes involved in Communities	52
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	39321
Length Of Smallest Path	3
Average Path Length	13.7558
Length of Longest Path	29
Minimum Path Strength	1.4
Average Path Strength	6.96133
Maximum Path Strength	20.36
Minimum Path Correlation	0.7
Average Path Correlation	0.920971
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	48.786
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.547
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • head development • forebrain development • brain development • nervous system development • pallium development • central nervous system development • telencephalon development • hippocampus development • limbic system development • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • response to estradiol • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • periplasmic space • somatodendritic compartment • cell body • perikaryon • neuronal cell body • postsynaptic specialization membrane • postsynaptic specialization • synaptic membrane • postsynapse • postsynaptic membrane • plasma membrane region • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8K3
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8K3
Name	3-(2-azanylethyl)-1H-indole-5-carboxamide
Synonyms
Identifier
Formula	C11 H13 N3 O
Molecular Weight	203.24
SMILES
PubChem	1809
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	0
Total Bonds	29
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47898
Sequence	>7X5H_nogp_Chain_R V F G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R T F H R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G R R W Q L G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R H M E Y T L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G W G E T Y S E G S E E C Q V S R E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V G S R E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C S C D I P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N Y N S A F K N F F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	10.1038/s41421-022-00412-3
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	10.1038/s41594-022-00796-6
	7UM7	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Methylergometrine	-	chim(NtGi1-Go)/β1/γ2	2.75	2022-07-20	10.1038/s41594-022-00796-6
	7UM7 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Methylergometrine	-		2.75	2022-07-20	10.1038/s41594-022-00796-6
	7UM6	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Lisuride	-	chim(NtGi1-Go)/β1/γ2	2.79	2022-07-20	10.1038/s41594-022-00796-6
	7UM6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Lisuride	-		2.79	2022-07-20	10.1038/s41594-022-00796-6
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	10.1038/s41594-022-00796-6

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