psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L42	R:R:T45	4.42	No	No	0	4	4
2	R:R:L44	R:R:L98	4.15	No	No	0	5	6
3	R:R:L47	R:R:W325	4.56	No	Yes	0	6	6
4	R:R:A53	R:R:F49	4.16	No	No	0	4	4
5	R:R:A90	R:R:T54	3.36	No	No	0	7	7
6	R:R:S331	R:R:T54	3.2	No	No	0	9	7
7	R:R:F332	R:R:T54	3.89	Yes	No	0	6	7
8	R:R:A90	R:R:F55	4.16	No	No	0	7	6
9	R:R:A91	R:R:F55	4.16	No	No	0	4	6
10	R:R:F332	R:R:W57	7.02	Yes	No	0	6	8
11	R:R:P335	R:R:W57	10.81	No	No	0	9	8
12	R:R:L336	R:R:W57	6.83	No	No	0	6	8
13	R:R:A83	R:R:N58	3.13	No	No	0	9	9
14	R:R:D86	R:R:N58	10.77	Yes	No	0	9	9
15	R:R:N58	R:R:P335	8.15	No	No	0	9	9
16	R:R:F349	R:R:L60	8.53	No	No	0	8	6
17	R:R:I65	R:R:V61	3.07	No	No	0	7	9
18	R:R:T339	R:R:V61	3.17	No	No	0	7	9
19	R:R:A83	R:R:L62	3.15	No	No	0	9	7
20	R:R:A63	R:R:R67	5.53	No	No	0	5	5
21	R:R:F352	R:R:R67	33.14	No	No	0	6	5
22	R:R:T70	R:R:V68	6.35	No	No	0	6	5
23	R:R:H72	R:R:R69	5.64	No	No	0	8	7
24	R:R:F71	R:R:T70	7.78	Yes	No	0	8	6
25	R:R:F71	R:R:Y345	14.44	Yes	Yes	0	8	8
26	R:R:H76	R:R:R73	7.9	No	No	0	9	7
27	R:R:P75	R:R:V74	7.07	No	No	0	8	5
28	R:R:R154	R:R:V74	10.46	No	No	0	8	5
29	R:R:K155	R:R:V74	4.55	No	No	0	3	5
30	R:R:H76	R:R:P75	4.58	No	No	0	9	8
31	R:R:H76	R:R:Y345	9.8	No	Yes	0	9	8
32	R:R:L78	R:R:N77	6.87	No	Yes	0	8	4
33	R:R:N77	R:R:S158	4.47	Yes	No	0	4	7
34	R:R:N159	R:R:N77	4.09	No	Yes	0	3	4
35	R:R:I162	R:R:N77	5.66	No	Yes	0	8	4
36	R:R:D138	R:R:L78	4.07	No	No	0	9	8
37	R:R:V79	R:R:Y345	3.79	No	Yes	0	8	8
38	R:R:N131	R:R:S81	4.47	No	No	0	7	9
39	R:R:I162	R:R:S81	7.74	No	No	0	8	9
40	R:R:M82	R:R:N334	9.82	No	No	0	9	9
41	R:R:M82	R:R:Y338	7.18	No	Yes	0	9	9
42	R:R:S128	R:R:S85	4.89	No	No	0	9	8
43	R:R:D86	R:R:S128	4.42	Yes	No	0	9	9
44	R:R:D86	R:R:S331	5.89	Yes	No	0	9	9
45	R:R:D86	R:R:N334	6.73	Yes	No	0	9	9
46	R:R:C124	R:R:L88	4.76	No	No	0	6	6
47	R:R:V89	R:R:V93	3.21	No	No	0	7	7
48	R:R:M94	R:R:V89	6.09	Yes	No	0	7	7
49	R:R:D121	R:R:V93	7.3	No	No	1	8	7
50	R:R:V93	R:R:Y328	5.05	No	Yes	1	7	7
51	R:R:M94	R:R:W325	4.65	Yes	Yes	1	7	6
52	R:R:M94	R:R:Y328	7.18	Yes	Yes	1	7	7
53	R:R:L96	R:R:W117	10.25	No	Yes	0	5	5
54	R:R:S97	R:R:W117	3.71	No	Yes	0	6	5
55	R:R:H100	R:R:R105	7.9	No	Yes	0	5	6
56	R:R:H100	R:R:W107	6.35	No	Yes	0	5	8
57	R:R:E101	R:R:W325	5.45	No	Yes	0	5	6
58	R:R:L109	R:R:W107	4.56	No	Yes	0	6	8
59	R:R:C114	R:R:W107	9.14	No	Yes	5	9	8
60	R:R:W107	R:R:W117	14.06	Yes	Yes	0	8	5
61	R:R:C192	R:R:W107	6.53	No	Yes	5	9	8
62	R:R:E190	R:R:Q108	7.65	No	No	0	4	3
63	R:R:R111	R:R:Y185	16.46	No	No	0	4	4
64	R:R:E187	R:R:R111	13.96	No	No	0	2	4
65	R:R:Q115	R:R:R112	4.67	No	No	0	6	1
66	R:R:C114	R:R:C192	7.28	No	No	5	9	9
67	R:R:L177	R:R:Q115	5.32	No	No	0	6	6
68	R:R:Q115	R:R:Y185	9.02	No	No	0	6	4
69	R:R:I118	R:R:W117	7.05	No	Yes	0	6	5
70	R:R:I118	R:R:V194	3.07	No	No	0	6	4
71	R:R:D121	R:R:Y328	8.05	No	Yes	1	8	7
72	L:L:?1	R:R:D121	8.36	Yes	No	1	0	8
73	R:R:S173	R:R:V122	6.46	No	No	0	8	7
74	L:L:?1	R:R:V122	11.8	Yes	No	0	0	7
75	L:L:?1	R:R:C125	5.59	Yes	No	0	0	6
76	R:R:S169	R:R:T126	6.4	No	No	0	8	7
77	R:R:A208	R:R:T126	3.36	No	No	0	7	7
78	L:L:?1	R:R:T126	3.89	Yes	No	0	0	7
79	R:R:A127	R:R:W166	7.78	No	No	0	8	9
80	R:R:I129	R:R:P212	3.39	No	No	0	8	9
81	R:R:I129	R:R:W298	8.22	No	Yes	0	8	8
82	R:R:T165	R:R:W130	3.64	No	No	0	6	6
83	R:R:L168	R:R:W130	4.56	No	No	0	4	6
84	R:R:P212	R:R:W130	13.51	No	No	0	9	6
85	R:R:N131	R:R:T165	8.77	No	No	0	7	6
86	R:R:V132	R:R:Y338	3.79	No	Yes	0	8	9
87	R:R:T133	R:R:V215	3.17	No	No	0	6	6
88	R:R:A134	R:R:M161	3.22	No	No	0	7	5
89	R:R:I135	R:R:R139	5.01	No	No	4	9	9
90	R:R:I135	R:R:Y338	6.04	No	Yes	4	9	9
91	R:R:A136	R:R:Y220	4	No	Yes	0	8	9
92	R:R:L137	R:R:V215	4.47	No	No	0	6	6
93	R:R:D138	R:R:Y149	10.34	No	Yes	3	9	8
94	R:R:D138	R:R:R154	10.72	No	No	3	9	8
95	R:R:R139	R:R:Y338	4.12	No	Yes	4	9	9
96	R:R:W141	R:R:Y140	4.82	No	Yes	0	4	8
97	R:R:T144	R:R:Y140	4.99	No	Yes	6	6	8
98	R:R:F218	R:R:Y140	3.09	No	Yes	0	4	8
99	R:R:V219	R:R:Y140	11.36	No	Yes	0	6	8
100	R:R:K222	R:R:Y140	19.11	No	Yes	6	5	8
101	R:R:W141	R:R:Y149	8.68	No	Yes	0	4	8
102	R:R:M161	R:R:W141	3.49	No	No	0	5	4
103	R:R:I143	R:R:S142	3.1	No	No	0	9	8
104	R:R:K222	R:R:T144	7.51	No	No	6	5	6
105	R:R:E148	R:R:R145	10.47	No	No	0	5	5
106	R:R:M147	R:R:P146	3.35	No	No	0	7	8
107	R:R:R154	R:R:Y149	11.32	No	Yes	3	8	8
108	R:R:V157	R:R:Y149	5.05	No	Yes	0	6	8
109	R:R:L151	R:R:T150	8.84	No	No	0	4	5
110	R:R:K155	R:R:R152	8.66	No	No	0	3	5
111	R:R:T165	R:R:W166	3.64	No	No	0	6	9
112	R:R:P176	R:R:Y200	11.13	No	Yes	0	7	7
113	R:R:L177	R:R:T184	4.42	No	No	0	6	4
114	R:R:W181	R:R:Y200	5.79	No	Yes	0	7	7
115	R:R:F203	R:R:W181	4.01	No	No	0	4	7
116	R:R:E183	R:R:G182	3.27	No	No	0	4	5
117	R:R:G182	R:R:S195	3.71	No	No	0	5	3
118	R:R:E197	R:R:G182	4.91	No	No	0	6	5
119	R:R:T184	R:R:Y185	6.24	No	No	0	4	4
120	R:R:E191	R:R:S186	8.62	No	No	0	3	2
121	R:R:G188	R:R:S189	3.71	No	No	0	4	3
122	R:R:E191	R:R:Q193	7.65	No	No	0	3	4
123	R:R:Q193	R:R:R196	10.51	No	No	0	4	4
124	R:R:S195	R:R:Y200	8.9	No	Yes	0	3	7
125	R:R:E197	R:R:P198	4.72	No	No	0	6	4
126	R:R:S204	R:R:Y200	7.63	No	Yes	0	6	7
127	R:R:A201	R:R:P309	3.74	No	No	0	6	5
128	L:L:?1	R:R:S204	10.57	Yes	No	0	0	6
129	R:R:T205	R:R:Y210	3.75	Yes	No	1	6	5
130	R:R:F302	R:R:T205	5.19	Yes	Yes	1	6	6
131	R:R:L306	R:R:T205	5.9	No	Yes	1	5	6
132	R:R:F209	R:R:F294	4.29	Yes	No	1	8	9
133	R:R:F209	R:R:W298	6.01	Yes	Yes	1	8	8
134	R:R:F209	R:R:I299	6.28	Yes	Yes	0	8	6
135	R:R:F209	R:R:F302	16.08	Yes	Yes	1	8	6
136	R:R:L306	R:R:Y210	4.69	No	No	1	5	5
137	R:R:L211	R:R:P212	4.93	No	No	0	6	9
138	R:R:I223	R:R:V219	3.07	No	No	0	9	6
139	R:R:L290	R:R:Y220	3.52	No	Yes	0	8	9
140	R:R:E280	R:R:Y224	3.37	No	Yes	0	7	6
141	R:R:A283	R:R:Y224	4	No	Yes	0	8	6
142	R:R:A284	R:R:Y224	4	No	Yes	0	7	6
143	R:R:A227	R:R:K279	3.21	No	No	0	8	5
144	R:R:E280	R:R:K228	6.75	No	No	0	7	5
145	R:R:Q278	R:R:Q281	7.68	No	No	0	5	5
146	R:R:A283	R:R:K279	4.82	No	No	0	8	5
147	R:R:I337	R:R:L290	4.28	No	No	0	8	8
148	R:R:G292	R:R:I291	3.53	No	No	0	5	8
149	R:R:I299	R:R:V295	4.61	Yes	No	0	6	5
150	R:R:C297	R:R:N330	6.3	No	No	0	8	9
151	R:R:F302	R:R:W298	6.01	Yes	Yes	1	6	8
152	R:R:G327	R:R:W298	8.44	No	Yes	0	7	8
153	R:R:N330	R:R:W298	3.39	No	Yes	0	9	8
154	R:R:I299	R:R:P300	3.39	Yes	No	0	6	9
155	R:R:F323	R:R:P300	7.22	No	No	0	5	9
156	R:R:F301	R:R:F302	11.79	No	Yes	1	7	6
157	L:L:?1	R:R:F301	10.72	Yes	No	1	0	7
158	L:L:?1	R:R:F302	6.43	Yes	Yes	1	0	6
159	R:R:I315	R:R:T304	4.56	Yes	No	0	4	5
160	L:L:?1	R:R:E305	11.66	Yes	No	0	0	7
161	R:R:C311	R:R:I307	3.27	No	No	0	3	5
162	R:R:I315	R:R:P316	5.08	Yes	No	0	4	5
163	R:R:I318	R:R:P316	3.39	No	No	0	1	5
164	R:R:I318	R:R:W319	3.52	No	No	0	1	4
165	R:R:L324	R:R:Y328	7.03	No	Yes	0	5	7
166	R:R:W325	R:R:Y328	3.86	Yes	Yes	1	6	7
167	L:L:?1	R:R:Y328	3.09	Yes	Yes	1	0	7
168	R:R:N330	R:R:N334	9.54	No	No	0	9	9
169	R:R:F332	R:R:F333	5.36	Yes	No	0	6	6
170	R:R:I337	R:R:Y338	10.88	No	Yes	0	8	9
171	R:R:T339	R:R:Y345	8.74	No	Yes	0	7	8
172	R:R:N342	R:R:N344	5.45	No	No	2	8	7
173	R:R:N342	R:R:Y345	6.98	No	Yes	2	8	8
174	R:R:K343	R:R:N346	5.6	No	No	0	5	9
175	R:R:N344	R:R:Y345	9.3	No	Yes	2	7	8
176	R:R:L123	R:R:S173	3	No	No	0	5	8
177	R:R:L62	R:R:V84	2.98	No	No	0	7	6
178	R:R:L296	R:R:V295	2.98	No	No	0	5	5
179	R:R:I289	R:R:I337	2.94	No	No	0	7	8
180	R:R:E191	R:R:S189	2.87	No	No	0	3	3
181	R:R:I299	R:R:L303	2.85	Yes	No	0	6	5
182	R:R:L137	R:R:M161	2.83	No	No	0	6	5
183	R:R:C192	R:R:R111	2.79	No	No	0	9	4
184	R:R:C156	R:R:R152	2.79	No	No	0	5	5
185	R:R:A348	R:R:F71	2.77	No	Yes	0	7	8
186	R:R:L213	R:R:L217	2.77	No	No	0	5	4
187	R:R:E305	R:R:K320	2.7	No	No	0	7	4
188	R:R:L109	R:R:Q108	2.66	No	No	0	6	3
189	R:R:E101	R:R:L98	2.65	No	No	0	5	6
190	R:R:F55	R:R:V87	2.62	No	No	0	6	7
191	L:L:?1	R:R:V194	2.62	Yes	No	0	0	4
192	R:R:F333	R:R:V293	2.62	No	No	0	6	5
193	R:R:R67	R:R:T64	2.59	No	No	0	5	7
194	R:R:F71	R:R:T64	2.59	Yes	No	0	8	7
195	R:R:R145	R:R:T144	2.59	No	No	0	5	6
196	R:R:F323	R:R:T304	2.59	No	No	0	5	5
197	R:R:V216	R:R:Y220	2.52	No	Yes	0	8	9
198	R:R:F341	R:R:M286	2.49	No	No	0	6	8
199	R:R:F209	R:R:L213	2.44	Yes	No	1	8	5
200	R:R:F294	R:R:L213	2.44	No	No	1	9	5
201	R:R:L113	R:R:W107	2.28	No	Yes	0	5	8
202	R:R:A175	R:R:P176	1.87	No	No	0	7	7
203	R:R:G48	R:R:V51	1.84	No	No	0	3	6
204	R:R:G207	R:R:V206	1.84	No	No	0	5	4
205	R:R:G292	R:R:V295	1.84	No	No	0	5	5
206	R:R:P309	R:R:S308	1.78	No	No	0	5	3
207	R:R:P95	R:R:V51	1.77	No	No	0	9	6
208	R:R:G40	R:R:I43	1.76	No	No	0	3	4
209	R:R:C124	R:R:V89	1.71	No	No	0	6	7
210	R:R:A119	R:R:S173	1.71	No	No	0	6	8
211	R:R:G327	R:R:L326	1.71	No	No	0	7	8
212	R:R:M94	R:R:P95	1.68	Yes	No	0	7	9
213	R:R:C313	R:R:I315	1.64	No	Yes	0	1	4
214	R:R:A80	R:R:I65	1.62	No	No	0	5	7
215	R:R:A226	R:R:I143	1.62	No	No	0	6	9
216	R:R:C120	R:R:L116	1.59	No	No	0	5	4
217	R:R:T205	R:R:V206	1.59	Yes	No	0	6	4
218	R:R:A119	R:R:L174	1.58	No	No	0	6	4
219	R:R:A170	R:R:L123	1.58	No	No	0	4	5
220	R:R:A340	R:R:L336	1.58	No	No	0	6	6
221	R:R:I172	R:R:S204	1.55	No	No	0	6	6
222	R:R:I315	R:R:S308	1.55	Yes	No	0	4	3
223	R:R:K343	R:R:S347	1.53	No	No	0	5	5
224	R:R:K279	R:R:V231	1.52	No	No	0	5	5
225	R:R:F179	R:R:G180	1.51	No	No	0	4	6
226	R:R:L50	R:R:S329	1.5	No	No	0	7	4
227	R:R:G104	R:R:R105	1.5	No	Yes	0	4	6
228	R:R:L42	R:R:V41	1.49	No	No	0	4	6
229	R:R:L164	R:R:V160	1.49	No	No	0	3	3
230	R:R:L46	R:R:T45	1.47	No	No	0	5	4
231	R:R:L60	R:R:T64	1.47	No	No	0	6	7
232	R:R:P146	R:R:R145	1.44	No	No	0	8	5
233	R:R:I289	R:R:L285	1.43	No	No	0	7	6
234	R:R:L285	R:R:M286	1.41	No	No	0	6	8
235	R:R:A53	R:R:F332	1.39	No	Yes	0	4	6
236	R:R:H100	R:R:S103	1.39	No	No	0	5	3
237	R:R:L88	R:R:L92	1.38	No	No	0	6	5
238	R:R:A317	R:R:R105	1.38	No	Yes	0	3	6
239	R:R:L113	R:R:L116	1.38	No	No	0	5	4
240	R:R:L174	R:R:L178	1.38	No	No	0	4	5
241	R:R:R106	R:R:S103	1.32	No	No	0	3	3
242	R:R:R105	R:R:S321	1.32	Yes	No	0	6	5
243	R:R:F333	R:R:S329	1.32	No	No	0	6	4
244	R:R:R230	R:R:V231	1.31	No	No	0	7	5
245	R:R:S142	R:R:Y149	1.27	No	Yes	0	8	8
246	R:R:V287	R:R:Y220	1.26	No	Yes	0	8	9
247	R:R:V287	R:R:Y224	1.26	No	Yes	0	8	6
248	R:R:F352	R:R:N351	1.21	No	No	0	6	5
249	R:R:Q278	R:R:R282	1.17	No	No	0	5	8
250	R:R:E305	R:R:R196	1.16	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F71	6.895	4	0	8
2	R:R:N77	5.2725	4	0	4
3	R:R:D86	6.9525	4	0	9
4	R:R:M94	4.9	4	1	7
5	R:R:R105	3.025	4	0	6
6	R:R:W107	7.15333	6	5	8
7	R:R:W117	8.7675	4	0	5
8	R:R:Y140	8.674	5	6	8
9	R:R:Y149	7.332	5	3	8
10	R:R:Y200	8.3625	4	0	7
11	R:R:T205	4.1075	4	1	6
12	R:R:F209	7.02	5	1	8
13	R:R:Y220	2.825	4	0	9
14	R:R:Y224	3.1575	4	0	6
15	R:R:W298	6.414	5	1	8
16	R:R:I299	4.2825	4	0	6
17	R:R:F302	9.1	5	1	6
18	R:R:I315	3.2075	4	0	4
19	R:R:W325	4.63	4	1	6
20	R:R:Y328	5.71	6	1	7
21	R:R:F332	4.415	4	0	6
22	R:R:Y338	6.402	5	4	9
23	R:R:Y345	8.84167	6	2	8
24	L:L:?1	7.473	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F332	R:R:T54	12.5314	3.89	Yes	No	0	6	7
2	R:R:S331	R:R:T54	20.8694	3.2	No	No	0	9	7
3	R:R:D86	R:R:S331	22.5047	5.89	Yes	No	0	9	9
4	R:R:D86	R:R:N334	40.3465	6.73	Yes	No	0	9	9
5	R:R:N330	R:R:N334	71.3349	9.54	No	No	0	9	9
6	R:R:N330	R:R:W298	73.4882	3.39	No	Yes	0	9	8
7	R:R:F302	R:R:W298	87.7439	6.01	Yes	Yes	1	6	8
8	L:L:?1	R:R:F302	100	6.43	Yes	Yes	1	0	6
9	L:L:?1	R:R:Y328	32.6641	3.09	Yes	Yes	1	0	7
10	R:R:D86	R:R:N58	13.6728	10.77	Yes	No	0	9	9
11	R:R:F71	R:R:T64	12.7904	2.59	Yes	No	0	8	7
12	R:R:F71	R:R:Y345	19.7199	14.44	Yes	Yes	0	8	8
13	R:R:H76	R:R:Y345	32.397	9.8	No	Yes	0	9	8
14	R:R:H76	R:R:P75	35.5541	4.58	No	No	0	9	8
15	R:R:P75	R:R:V74	37.0922	7.07	No	No	0	8	5
16	R:R:R154	R:R:V74	43.026	10.46	No	No	0	8	5
17	R:R:D138	R:R:R154	40.055	10.72	No	No	3	9	8
18	R:R:D138	R:R:L78	71.5211	4.07	No	No	0	9	8
19	R:R:L78	R:R:N77	72.6625	6.87	No	Yes	0	8	4
20	R:R:I162	R:R:N77	75.8034	5.66	No	Yes	0	8	4
21	R:R:I162	R:R:S81	76.8396	7.74	No	No	0	8	9
22	R:R:N131	R:R:S81	77.8434	4.47	No	No	0	7	9
23	R:R:N131	R:R:T165	78.8311	8.77	No	No	0	7	6
24	R:R:T165	R:R:W130	81.6968	3.64	No	No	0	6	6
25	R:R:P212	R:R:W130	83.5263	13.51	No	No	0	9	6
26	R:R:I129	R:R:P212	85.291	3.39	No	No	0	8	9
27	R:R:I129	R:R:W298	86.1491	8.22	No	Yes	0	8	8
28	R:R:M82	R:R:N334	39.0593	9.82	No	No	0	9	9
29	R:R:M82	R:R:Y338	37.4646	7.18	No	Yes	0	9	9
30	R:R:C124	R:R:V89	15.4618	1.71	No	No	0	6	7
31	R:R:C124	R:R:L88	10.3214	4.76	No	No	0	6	6
32	L:L:?1	R:R:V194	46.2479	2.62	Yes	No	0	0	4
33	R:R:I118	R:R:V194	44.985	3.07	No	No	0	6	4
34	R:R:I118	R:R:W117	43.7626	7.05	No	Yes	0	6	5
35	R:R:H100	R:R:W107	12.0861	6.35	No	Yes	0	5	8
36	R:R:W107	R:R:W117	39.6665	14.06	Yes	Yes	0	8	5
37	R:R:C192	R:R:W107	15.988	6.53	No	Yes	5	9	8
38	R:R:C192	R:R:R111	14.3123	2.79	No	No	0	9	4
39	R:R:R111	R:R:Y185	10.7666	16.46	No	No	0	4	4
40	L:L:?1	R:R:V122	12.7985	11.8	Yes	No	0	0	7
41	R:R:S173	R:R:V122	11.0176	6.46	No	No	0	8	7
42	R:R:D138	R:R:Y149	30.5594	10.34	No	Yes	3	9	8
43	R:R:W141	R:R:Y149	27.3861	8.68	No	Yes	0	4	8
44	R:R:W141	R:R:Y140	17.3642	4.82	No	Yes	0	4	8
45	L:L:?1	R:R:S204	21.4604	10.57	Yes	No	0	0	6
46	R:R:S204	R:R:Y200	18.0442	7.63	No	Yes	0	6	7
47	R:R:E305	R:R:R196	10.5804	1.16	No	No	0	7	4
48	L:L:?1	R:R:E305	13.7861	11.66	Yes	No	0	0	7
49	R:R:I315	R:R:T304	14.3285	4.56	Yes	No	0	4	5
50	R:R:F323	R:R:T304	16.0852	2.59	No	No	0	5	5
51	R:R:F323	R:R:P300	17.8256	7.22	No	No	0	5	9
52	R:R:I299	R:R:P300	19.5418	3.39	Yes	No	0	6	9
53	R:R:F209	R:R:I299	29.4989	6.28	Yes	Yes	0	8	6
54	R:R:F209	R:R:F302	15.899	16.08	Yes	Yes	1	8	6
55	R:R:I337	R:R:Y338	31.2475	10.88	No	Yes	0	8	9
56	R:R:I337	R:R:L290	23.5408	4.28	No	No	0	8	8
57	R:R:L290	R:R:Y220	22.0918	3.52	No	Yes	0	8	9
58	R:R:V287	R:R:Y220	17.3885	1.26	No	Yes	0	8	9
59	R:R:V287	R:R:Y224	15.648	1.26	No	Yes	0	8	6
60	R:R:V89	R:R:V93	13.5595	3.21	No	No	0	7	7
61	R:R:M94	R:R:Y328	13.5918	7.18	Yes	Yes	1	7	7
62	R:R:F209	R:R:W298	19.9061	6.01	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D121	R:R:V93	7.3	1	No	No	8	7	1	2
R:R:V93	R:R:Y328	5.05	1	No	Yes	7	7	2	1
R:R:M94	R:R:W325	4.65	1	Yes	Yes	7	6	2	2
R:R:M94	R:R:Y328	7.18	1	Yes	Yes	7	7	2	1
R:R:I118	R:R:V194	3.07	0	No	No	6	4	2	1
R:R:D121	R:R:Y328	8.05	1	No	Yes	8	7	1	1
L:L:?1	R:R:D121	8.36	1	Yes	No	0	8	0	1
R:R:S173	R:R:V122	6.46	0	No	No	8	7	2	1
L:L:?1	R:R:V122	11.8	1	Yes	No	0	7	0	1
L:L:?1	R:R:C125	5.59	1	Yes	No	0	6	0	1
R:R:S169	R:R:T126	6.4	0	No	No	8	7	2	1
R:R:A208	R:R:T126	3.36	0	No	No	7	7	2	1
L:L:?1	R:R:T126	3.89	1	Yes	No	0	7	0	1
R:R:S204	R:R:Y200	7.63	0	No	Yes	6	7	1	2
L:L:?1	R:R:S204	10.57	1	Yes	No	0	6	0	1
R:R:F302	R:R:T205	5.19	1	Yes	Yes	6	6	1	2
R:R:F209	R:R:W298	6.01	1	Yes	Yes	8	8	2	2
R:R:F209	R:R:F302	16.08	1	Yes	Yes	8	6	2	1
R:R:F302	R:R:W298	6.01	1	Yes	Yes	6	8	1	2
R:R:F301	R:R:F302	11.79	1	No	Yes	7	6	1	1
L:L:?1	R:R:F301	10.72	1	Yes	No	0	7	0	1
L:L:?1	R:R:F302	6.43	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:E305	11.66	1	Yes	No	0	7	0	1
R:R:L324	R:R:Y328	7.03	0	No	Yes	5	7	2	1
R:R:W325	R:R:Y328	3.86	1	Yes	Yes	6	7	2	1
L:L:?1	R:R:Y328	3.09	1	Yes	Yes	0	7	0	1
R:R:E305	R:R:K320	2.7	0	No	No	7	4	1	2
L:L:?1	R:R:V194	2.62	1	Yes	No	0	4	0	1
R:R:I172	R:R:S204	1.55	0	No	No	6	6	2	1
R:R:E305	R:R:R196	1.16	0	No	No	7	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7UM5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	245
Number of Links	250
Number of Hubs	24
Number of Links mediated by Hubs	102
Number of Communities	6
Number of Nodes involved in Communities	30
Number of Links involved in Communities	36

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	26030
Length Of Smallest Path	3
Average Path Length	14.4174
Length of Longest Path	34
Minimum Path Strength	1.355
Average Path Strength	6.30773
Maximum Path Strength	19.335
Minimum Path Correlation	0.7
Average Path Correlation	0.921488
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	51.4482
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.8574
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • developmental process • multicellular organismal process • head development • forebrain development • animal organ development • brain development • nervous system development • pallium development • multicellular organism development • central nervous system development • anatomical structure development • telencephalon development • hippocampus development • limbic system development • system development • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • response to lipid • response to chemical • response to estradiol • response to oxygen-containing compound • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • cell body • perikaryon • neuronal cell body • postsynaptic specialization membrane • postsynaptic specialization • synaptic membrane • postsynapse • postsynaptic membrane • plasma membrane region • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to monoamine stimulus • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8K3
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8K3
Name	3-(2-azanylethyl)-1H-indole-5-carboxamide
Synonyms
Identifier
Formula	C11 H13 N3 O
Molecular Weight	203.24
SMILES
PubChem	1809
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	0
Total Bonds	29
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47898
Sequence	>7UM5_nogp_Chain_R G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R T F H R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G R R W Q L G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R P M E Y T L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G W G E T Y S E G S E E C Q V S R E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C S C D I P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N Y N S A F K N F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	10.1038/s41421-022-00412-3
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	10.1038/s41594-022-00796-6
	7UM7	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Methylergometrine	-	chim(NtGi1-Go)/β1/γ2	2.75	2022-07-20	10.1038/s41594-022-00796-6
	7UM7 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Methylergometrine	-		2.75	2022-07-20	10.1038/s41594-022-00796-6
	7UM6	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Lisuride	-	chim(NtGi1-Go)/β1/γ2	2.79	2022-07-20	10.1038/s41594-022-00796-6
	7UM6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Lisuride	-		2.79	2022-07-20	10.1038/s41594-022-00796-6
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	10.1038/s41594-022-00796-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7UM5_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.