psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G40	R:R:I43	3.53	No	No	0	3	4
2	R:R:F332	R:R:L50	3.65	Yes	No	0	6	7
3	R:R:A90	R:R:T54	3.36	No	No	0	7	7
4	R:R:S331	R:R:T54	3.2	No	No	0	9	7
5	R:R:F332	R:R:T54	3.89	Yes	No	0	6	7
6	R:R:F55	R:R:L59	4.87	No	No	0	6	4
7	R:R:F55	R:R:V87	3.93	No	No	0	6	7
8	R:R:F332	R:R:W57	6.01	Yes	Yes	0	6	8
9	R:R:P335	R:R:W57	4.05	No	Yes	0	9	8
10	R:R:L336	R:R:W57	6.83	No	Yes	0	6	8
11	R:R:D86	R:R:N58	8.08	Yes	No	0	9	9
12	R:R:N58	R:R:P335	4.89	No	No	0	9	9
13	R:R:L60	R:R:T64	4.42	No	No	0	6	7
14	R:R:F349	R:R:L60	6.09	No	No	0	8	6
15	R:R:I65	R:R:V61	3.07	Yes	No	0	7	9
16	R:R:A83	R:R:V61	3.39	No	No	0	9	9
17	R:R:T70	R:R:V68	3.17	No	No	0	6	5
18	R:R:F71	R:R:T70	5.19	Yes	No	0	8	6
19	R:R:R73	R:R:T70	7.76	No	No	0	7	6
20	R:R:F71	R:R:N344	3.62	Yes	No	0	8	7
21	R:R:F71	R:R:Y345	7.22	Yes	Yes	0	8	8
22	R:R:A348	R:R:F71	4.16	No	Yes	0	7	8
23	R:R:H76	R:R:R73	6.77	No	No	0	9	7
24	R:R:P75	R:R:V74	3.53	No	No	2	8	5
25	R:R:R154	R:R:V74	6.54	Yes	No	2	8	5
26	R:R:H76	R:R:P75	3.05	No	No	0	9	8
27	R:R:P75	R:R:R154	4.32	No	Yes	2	8	8
28	R:R:H76	R:R:Y345	3.27	No	Yes	0	9	8
29	R:R:L78	R:R:N77	6.87	No	Yes	2	8	4
30	R:R:N77	R:R:S158	8.94	Yes	No	2	4	7
31	R:R:N159	R:R:N77	4.09	No	Yes	0	3	4
32	R:R:I162	R:R:N77	4.25	No	Yes	0	8	4
33	R:R:D138	R:R:L78	4.07	No	No	2	9	8
34	R:R:L78	R:R:S158	4.5	No	No	2	8	7
35	R:R:V79	R:R:Y345	3.79	No	Yes	0	8	8
36	R:R:N131	R:R:S81	5.96	Yes	No	0	7	9
37	R:R:I162	R:R:S81	4.64	No	No	0	8	9
38	R:R:S81	R:R:W166	4.94	No	No	0	9	9
39	R:R:D86	R:R:M82	4.16	Yes	No	0	9	9
40	R:R:M82	R:R:N131	7.01	No	Yes	0	9	7
41	R:R:M82	R:R:Y338	3.59	No	Yes	0	9	9
42	R:R:S128	R:R:S85	4.89	No	No	0	9	8
43	R:R:N131	R:R:S85	4.47	Yes	No	0	7	8
44	R:R:D86	R:R:S331	4.42	Yes	No	0	9	9
45	R:R:D86	R:R:N334	5.39	Yes	No	0	9	9
46	R:R:C124	R:R:L88	4.76	No	No	0	6	6
47	R:R:D121	R:R:V93	8.76	No	No	1	8	7
48	R:R:V93	R:R:Y328	3.79	No	Yes	1	7	7
49	R:R:M94	R:R:Y328	4.79	No	Yes	0	7	7
50	R:R:L113	R:R:L96	4.15	Yes	No	0	5	5
51	R:R:L96	R:R:W117	3.42	No	Yes	0	5	5
52	R:R:S97	R:R:W117	4.94	No	Yes	0	6	5
53	R:R:L102	R:R:L98	4.15	No	No	0	5	6
54	R:R:H100	R:R:W107	8.46	No	Yes	1	5	8
55	R:R:H100	R:R:W117	6.35	No	Yes	1	5	5
56	R:R:E101	R:R:W325	6.54	No	No	0	5	6
57	R:R:R105	R:R:R106	6.4	No	No	0	6	3
58	R:R:E191	R:R:R105	6.98	No	No	0	3	6
59	R:R:E190	R:R:R106	4.65	No	No	0	4	3
60	R:R:L113	R:R:W107	5.69	Yes	Yes	0	5	8
61	R:R:C114	R:R:W107	3.92	No	Yes	1	9	8
62	R:R:W107	R:R:W117	8.43	Yes	Yes	1	8	5
63	R:R:C192	R:R:W107	5.22	Yes	Yes	1	9	8
64	R:R:L109	R:R:Q108	3.99	No	No	0	6	3
65	R:R:L109	R:R:L113	9.69	No	Yes	0	6	5
66	R:R:L116	R:R:R112	4.86	No	No	0	4	1
67	R:R:C114	R:R:C192	7.28	No	Yes	1	9	9
68	R:R:L177	R:R:Q115	7.99	No	No	0	6	6
69	R:R:C192	R:R:W117	3.92	Yes	Yes	1	9	5
70	L:L:?1	R:R:W117	8.11	Yes	Yes	1	0	5
71	R:R:C192	R:R:I118	3.27	Yes	No	0	9	6
72	R:R:D121	R:R:Y328	9.2	No	Yes	1	8	7
73	L:L:?1	R:R:D121	18.25	Yes	No	1	0	8
74	R:R:S173	R:R:V122	4.85	No	No	0	8	7
75	L:L:?1	R:R:V122	5.89	Yes	No	0	0	7
76	R:R:L123	R:R:S169	6.01	No	No	0	5	8
77	R:R:C125	R:R:W298	5.22	No	Yes	0	6	8
78	L:L:?1	R:R:C125	6.28	Yes	No	0	0	6
79	R:R:S169	R:R:T126	7.99	No	No	0	8	7
80	R:R:A208	R:R:T126	3.36	No	No	0	7	7
81	L:L:?1	R:R:T126	6.99	Yes	No	0	0	7
82	R:R:A127	R:R:W166	6.48	No	No	0	8	9
83	R:R:I129	R:R:P212	3.39	No	No	0	8	9
84	R:R:F294	R:R:I129	3.77	No	No	0	9	8
85	R:R:I129	R:R:W298	8.22	No	Yes	0	8	8
86	R:R:L168	R:R:W130	4.56	No	No	0	4	6
87	R:R:P212	R:R:W130	8.11	No	No	0	9	6
88	R:R:N131	R:R:T165	7.31	Yes	No	0	7	6
89	R:R:V132	R:R:Y338	3.79	No	Yes	0	8	9
90	R:R:T133	R:R:V215	3.17	No	No	0	6	6
91	R:R:T133	R:R:V216	4.76	No	No	0	6	8
92	R:R:A134	R:R:M161	4.83	No	No	0	7	5
93	R:R:I135	R:R:R139	5.01	No	No	3	9	9
94	R:R:I135	R:R:Y338	8.46	No	Yes	3	9	9
95	R:R:A136	R:R:Y220	5.34	No	Yes	0	8	9
96	R:R:L137	R:R:W141	3.42	No	Yes	0	6	4
97	R:R:L137	R:R:M161	4.24	No	No	0	6	5
98	R:R:D138	R:R:Y149	8.05	No	Yes	2	9	8
99	R:R:D138	R:R:R154	13.1	No	Yes	2	9	8
100	R:R:R139	R:R:Y220	3.09	No	Yes	0	9	9
101	R:R:R139	R:R:Y338	6.17	No	Yes	3	9	9
102	R:R:W141	R:R:Y140	4.82	Yes	Yes	0	4	8
103	R:R:T144	R:R:Y140	6.24	No	Yes	0	6	8
104	R:R:V219	R:R:Y140	7.57	No	Yes	0	6	8
105	R:R:K222	R:R:Y140	3.58	No	Yes	0	5	8
106	R:R:R145	R:R:W141	4	No	Yes	0	5	4
107	R:R:W141	R:R:Y149	7.72	Yes	Yes	0	4	8
108	R:R:I143	R:R:S142	3.1	No	No	0	9	8
109	R:R:R145	R:R:T144	6.47	No	No	0	5	6
110	R:R:R154	R:R:Y149	15.43	Yes	Yes	2	8	8
111	R:R:V157	R:R:Y149	6.31	No	Yes	0	6	8
112	R:R:L151	R:R:T150	7.37	No	No	0	4	5
113	R:R:K155	R:R:N159	4.2	No	No	0	3	3
114	R:R:L177	R:R:P176	3.28	No	No	0	6	7
115	R:R:P176	R:R:Y200	8.34	No	No	0	7	7
116	R:R:E191	R:R:Q193	8.92	No	No	0	3	4
117	R:R:R196	R:R:V194	3.92	No	No	0	4	4
118	R:R:E197	R:R:S195	7.19	No	No	0	6	3
119	R:R:S195	R:R:Y200	3.82	No	No	0	3	7
120	R:R:E305	R:R:R196	12.79	No	No	0	7	4
121	R:R:S204	R:R:Y200	17.8	No	No	0	6	7
122	R:R:A201	R:R:P309	3.74	No	No	0	6	5
123	L:L:?1	R:R:S204	3.56	Yes	No	0	0	6
124	R:R:T205	R:R:Y210	4.99	No	Yes	0	6	5
125	R:R:F302	R:R:T205	6.49	Yes	No	0	6	6
126	R:R:E305	R:R:T205	7.06	No	No	0	7	6
127	R:R:V206	R:R:Y210	6.31	No	Yes	0	4	5
128	R:R:F209	R:R:Y210	3.09	Yes	Yes	0	8	5
129	R:R:F209	R:R:F294	6.43	Yes	No	1	8	9
130	R:R:F209	R:R:W298	6.01	Yes	Yes	1	8	8
131	R:R:F209	R:R:I299	6.28	Yes	No	0	8	6
132	R:R:F209	R:R:F302	16.08	Yes	Yes	1	8	6
133	R:R:L306	R:R:Y210	3.52	No	Yes	0	5	5
134	R:R:L211	R:R:P212	3.28	No	No	0	6	9
135	R:R:L213	R:R:L217	4.15	No	No	0	5	4
136	R:R:V287	R:R:Y220	3.79	No	Yes	0	8	9
137	R:R:L290	R:R:Y220	3.52	No	Yes	0	8	9
138	R:R:K228	R:R:Y224	11.94	No	No	0	5	6
139	R:R:E280	R:R:K228	14.85	No	No	0	7	5
140	R:R:E280	R:R:V231	5.7	No	No	0	7	5
141	R:R:E277	R:R:K279	4.05	No	No	0	4	5
142	R:R:E277	R:R:E280	5.07	No	No	0	4	7
143	R:R:K279	R:R:R282	12.38	No	No	0	5	8
144	R:R:I337	R:R:L290	4.28	No	No	0	8	8
145	R:R:L290	R:R:Y338	4.69	No	Yes	0	8	9
146	R:R:F333	R:R:V293	3.93	No	No	0	6	5
147	R:R:I299	R:R:V295	4.61	No	No	0	6	5
148	R:R:C297	R:R:N330	7.87	No	No	0	8	9
149	R:R:F302	R:R:W298	5.01	Yes	Yes	1	6	8
150	R:R:G327	R:R:W298	8.44	No	Yes	0	7	8
151	R:R:N330	R:R:W298	5.65	No	Yes	0	9	8
152	R:R:I299	R:R:P300	3.39	No	No	0	6	9
153	R:R:F323	R:R:P300	4.33	No	No	0	5	9
154	R:R:F301	R:R:F302	3.22	No	Yes	1	7	6
155	R:R:F301	R:R:L324	3.65	No	No	1	7	5
156	L:L:?1	R:R:F301	8.67	Yes	No	1	0	7
157	L:L:?1	R:R:F302	6.74	Yes	Yes	1	0	6
158	R:R:P309	R:R:S308	3.56	No	Yes	0	5	3
159	R:R:C313	R:R:S308	3.44	No	Yes	0	1	3
160	R:R:I315	R:R:S308	3.1	Yes	Yes	0	4	3
161	R:R:I315	R:R:P316	5.08	Yes	No	0	4	5
162	R:R:I315	R:R:K320	8.72	Yes	No	0	4	4
163	R:R:I318	R:R:P316	3.39	No	No	4	1	5
164	R:R:P316	R:R:W319	10.81	No	No	4	5	4
165	R:R:I318	R:R:W319	5.87	No	No	4	1	4
166	L:L:?1	R:R:L324	10.95	Yes	No	1	0	5
167	R:R:W325	R:R:Y328	6.75	No	Yes	0	6	7
168	L:L:?1	R:R:Y328	5.56	Yes	Yes	1	0	7
169	R:R:N330	R:R:N334	9.54	No	No	0	9	9
170	R:R:F332	R:R:F333	3.22	Yes	No	0	6	6
171	R:R:T339	R:R:Y345	11.24	No	Yes	0	7	8
172	R:R:N342	R:R:Y345	5.81	No	Yes	0	8	8
173	R:R:M94	R:R:V51	3.04	No	No	0	7	6
174	R:R:M94	R:R:V89	3.04	No	No	0	7	7
175	R:R:I315	R:R:T304	3.04	Yes	No	0	4	5
176	R:R:G110	R:R:R111	3	No	No	0	7	4
177	R:R:L326	R:R:S329	3	No	No	0	8	4
178	R:R:L137	R:R:V215	2.98	No	No	0	6	6
179	R:R:L164	R:R:V160	2.98	No	No	0	3	3
180	R:R:N344	R:R:S347	2.98	No	No	0	7	5
181	R:R:I289	R:R:I337	2.94	No	No	0	7	8
182	R:R:I43	R:R:L47	2.85	No	No	0	4	6
183	R:R:I65	R:R:L66	2.85	Yes	No	0	7	4
184	R:R:I291	R:R:L217	2.85	No	No	0	8	4
185	R:R:I322	R:R:L326	2.85	No	No	0	3	8
186	R:R:C114	R:R:R111	2.79	No	No	0	9	4
187	R:R:L102	R:R:L44	2.77	No	No	0	5	5
188	R:R:A91	R:R:F55	2.77	No	No	0	4	6
189	R:R:L174	R:R:L178	2.77	No	No	0	4	5
190	R:R:L306	R:R:L310	2.77	No	No	0	5	5
191	R:R:L285	R:R:Q281	2.66	No	No	0	6	5
192	R:R:E101	R:R:L98	2.65	No	No	0	5	6
193	R:R:R154	R:R:S142	2.64	Yes	No	0	8	8
194	R:R:F333	R:R:S329	2.64	No	No	0	6	4
195	R:R:F71	R:R:T64	2.59	Yes	No	0	8	7
196	R:R:F323	R:R:T304	2.59	No	No	0	5	5
197	R:R:F341	R:R:K343	2.48	No	No	0	6	5
198	R:R:E191	R:R:H100	2.46	No	No	0	3	5
199	R:R:F179	R:R:L178	2.44	No	No	0	4	5
200	R:R:F209	R:R:L213	2.44	Yes	No	1	8	5
201	R:R:F294	R:R:L213	2.44	No	No	1	9	5
202	R:R:L113	R:R:R112	2.43	Yes	No	0	5	1
203	R:R:I65	R:R:Y345	2.42	Yes	Yes	0	7	8
204	R:R:I223	R:R:Y140	2.42	No	Yes	0	9	8
205	R:R:I223	R:R:Y220	2.42	No	Yes	0	9	9
206	R:R:L47	R:R:W325	2.28	No	No	0	6	6
207	R:R:A175	R:R:P176	1.87	No	No	0	7	7
208	R:R:G104	R:R:S103	1.86	No	No	0	4	3
209	R:R:G292	R:R:V295	1.84	No	No	0	5	5
210	R:R:A227	R:R:A283	1.79	No	No	0	8	8
211	R:R:P95	R:R:V51	1.77	No	No	0	9	6
212	R:R:C124	R:R:V89	1.71	No	No	0	6	7
213	R:R:C120	R:R:V93	1.71	No	No	0	5	7
214	R:R:A119	R:R:S173	1.71	No	No	0	6	8
215	R:R:M147	R:R:P146	1.68	No	No	0	7	8
216	R:R:C311	R:R:I307	1.64	No	No	0	3	5
217	R:R:A80	R:R:I65	1.62	No	Yes	0	5	7
218	R:R:A208	R:R:I172	1.62	No	No	0	7	6
219	R:R:V202	R:R:V206	1.6	No	No	0	6	4
220	R:R:C120	R:R:L92	1.59	No	No	0	5	5
221	R:R:A83	R:R:L62	1.58	No	No	0	9	7
222	R:R:A91	R:R:L92	1.58	No	No	0	4	5
223	R:R:A170	R:R:L123	1.58	No	No	0	4	5
224	R:R:A170	R:R:L174	1.58	No	No	0	4	4
225	R:R:E197	R:R:P198	1.57	No	No	0	6	4
226	R:R:I307	R:R:S308	1.55	No	Yes	0	5	3
227	R:R:I322	R:R:S321	1.55	No	No	0	3	5
228	R:R:A284	R:R:Q281	1.52	No	No	0	7	5
229	R:R:L88	R:R:V84	1.49	No	No	0	6	6
230	R:R:L42	R:R:T45	1.47	No	No	0	4	4
231	R:R:P146	R:R:R145	1.44	No	No	0	8	5
232	R:R:Q108	R:R:V99	1.43	No	No	0	3	5
233	R:R:A53	R:R:F332	1.39	No	Yes	0	4	6
234	R:R:A340	R:R:F341	1.39	No	No	0	6	6
235	R:R:A284	R:R:Y224	1.33	No	No	0	7	6
236	R:R:R106	R:R:S103	1.32	No	No	0	3	3
237	R:R:R67	R:R:V68	1.31	No	No	0	5	5
238	R:R:A340	R:R:W57	1.3	No	Yes	0	6	8
239	R:R:H72	R:R:L66	1.29	No	No	0	8	4
240	R:R:E277	R:R:Q278	1.27	No	No	0	4	5
241	R:R:T153	R:R:Y149	1.25	No	Yes	0	7	8
242	R:R:F218	R:R:K222	1.24	No	No	0	4	5
243	R:R:M286	R:R:R282	1.24	No	No	0	8	8
244	R:R:F341	R:R:M286	1.24	No	No	0	6	8
245	R:R:L303	R:R:Y210	1.17	No	Yes	0	5	5
246	R:R:K225	R:R:W221	1.16	No	No	0	4	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W57	4.5475	4	0	8
2	R:R:I65	2.49	4	0	7
3	R:R:F71	4.556	5	0	8
4	R:R:N77	6.0375	4	2	4
5	R:R:D86	5.5125	4	0	9
6	R:R:W107	6.344	5	1	8
7	R:R:L113	5.49	4	0	5
8	R:R:W117	5.86167	6	1	5
9	R:R:N131	6.1875	4	0	7
10	R:R:Y140	4.926	5	0	8
11	R:R:W141	4.99	4	0	4
12	R:R:Y149	7.752	5	2	8
13	R:R:R154	8.406	5	2	8
14	R:R:C192	4.9225	4	1	9
15	R:R:F209	6.72167	6	1	8
16	R:R:Y210	3.816	5	0	5
17	R:R:Y220	3.632	5	0	9
18	R:R:W298	6.425	6	1	8
19	R:R:F302	7.508	5	1	6
20	R:R:S308	2.9125	4	0	3
21	R:R:I315	4.985	4	0	4
22	R:R:Y328	6.018	5	1	7
23	R:R:F332	3.632	5	0	6
24	R:R:Y338	5.34	5	3	9
25	R:R:Y345	5.625	6	0	8
26	L:L:?1	8.1	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F332	R:R:T54	10.1703	3.89	Yes	No	0	6	7
2	R:R:S331	R:R:T54	12.2327	3.2	No	No	0	9	7
3	R:R:D86	R:R:S331	13.2604	4.42	Yes	No	0	9	9
4	R:R:D86	R:R:N334	99.1591	5.39	Yes	No	0	9	9
5	R:R:N330	R:R:N334	99.4463	9.54	No	No	0	9	9
6	R:R:N330	R:R:W298	100	5.65	No	Yes	0	9	8
7	R:R:C125	R:R:W298	42.3801	5.22	No	Yes	0	6	8
8	L:L:?1	R:R:C125	42.0133	6.28	Yes	No	0	0	6
9	L:L:?1	R:R:Y328	29.9502	5.56	Yes	Yes	1	0	7
10	R:R:W325	R:R:Y328	10.4263	6.75	No	Yes	0	6	7
11	R:R:F302	R:R:W298	45.1969	5.01	Yes	Yes	1	6	8
12	L:L:?1	R:R:F302	53.2909	6.74	Yes	Yes	1	0	6
13	R:R:A91	R:R:L92	10.9592	1.58	No	No	0	4	5
14	R:R:C120	R:R:L92	13.6826	1.59	No	No	0	5	5
15	R:R:C120	R:R:V93	16.3991	1.71	No	No	0	5	7
16	R:R:D86	R:R:N58	20.5931	8.08	Yes	No	0	9	9
17	R:R:N58	R:R:P335	19.5584	4.89	No	No	0	9	9
18	R:R:P335	R:R:W57	18.5307	4.05	No	Yes	0	9	8
19	R:R:D86	R:R:M82	86.6115	4.16	Yes	No	0	9	9
20	R:R:M82	R:R:N131	39.7813	7.01	No	Yes	0	9	7
21	R:R:N131	R:R:S81	36.2932	5.96	Yes	No	0	7	9
22	R:R:I162	R:R:S81	33.9366	4.64	No	No	0	8	9
23	R:R:I162	R:R:N77	33.1684	4.25	No	Yes	0	8	4
24	R:R:L78	R:R:N77	29.9259	6.87	No	Yes	2	8	4
25	R:R:D138	R:R:L78	29.2927	4.07	No	No	2	9	8
26	R:R:D138	R:R:R154	25.4966	13.1	No	Yes	2	9	8
27	R:R:P75	R:R:R154	24.5069	4.32	No	Yes	2	8	8
28	R:R:H76	R:R:P75	23.6798	3.05	No	No	0	9	8
29	R:R:H76	R:R:Y345	18.5203	3.27	No	Yes	0	9	8
30	R:R:M82	R:R:Y338	48.6608	3.59	No	Yes	0	9	9
31	L:L:?1	R:R:W117	40.7952	8.11	Yes	Yes	1	0	5
32	R:R:W107	R:R:W117	13.0182	8.43	Yes	Yes	1	8	5
33	R:R:H100	R:R:W117	10.2879	6.35	No	Yes	1	5	5
34	L:L:?1	R:R:S204	12.3054	3.56	Yes	No	0	0	6
35	R:R:S204	R:R:Y200	11.0804	17.8	No	No	0	6	7
36	L:L:?1	R:R:T126	12.6376	6.99	Yes	No	0	0	7
37	R:R:R139	R:R:Y338	22.5414	6.17	No	Yes	3	9	9
38	R:R:R139	R:R:Y220	22.088	3.09	No	Yes	0	9	9
39	R:R:I223	R:R:Y220	39.7156	2.42	No	Yes	0	9	9
40	R:R:I223	R:R:Y140	38.0199	2.42	No	Yes	0	9	8
41	R:R:W141	R:R:Y140	24.3339	4.82	Yes	Yes	0	4	8
42	R:R:L137	R:R:W141	11.3745	3.42	No	Yes	0	6	4
43	R:R:L290	R:R:Y338	24.2474	4.69	No	Yes	0	8	9
44	R:R:L290	R:R:Y220	22.088	3.52	No	Yes	0	8	9
45	R:R:F323	R:R:T304	10.8001	2.59	No	No	0	5	5
46	R:R:F323	R:R:P300	11.6721	4.33	No	No	0	5	9
47	R:R:I299	R:R:P300	12.5337	3.39	No	No	0	6	9
48	R:R:F209	R:R:I299	15.0772	6.28	Yes	No	0	8	6
49	R:R:A340	R:R:W57	16.9147	1.3	No	Yes	0	6	8
50	R:R:A340	R:R:F341	15.925	1.39	No	No	0	6	6
51	R:R:F341	R:R:M286	13.648	1.24	No	No	0	6	8
52	R:R:M286	R:R:R282	12.6964	1.24	No	No	0	8	8
53	R:R:K279	R:R:R282	11.5441	12.38	No	No	0	5	8
54	R:R:E277	R:R:K279	10.3848	4.05	No	No	0	4	5
55	L:L:?1	R:R:D121	10.6132	18.25	Yes	No	1	0	8
56	R:R:F209	R:R:W298	13.7968	6.01	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D121	R:R:V93	8.76	1	No	No	8	7	1	2
R:R:V93	R:R:Y328	3.79	1	No	Yes	7	7	2	1
R:R:M94	R:R:Y328	4.79	0	No	Yes	7	7	2	1
R:R:L96	R:R:W117	3.42	0	No	Yes	5	5	2	1
R:R:S97	R:R:W117	4.94	0	No	Yes	6	5	2	1
R:R:H100	R:R:W107	8.46	1	No	Yes	5	8	2	2
R:R:H100	R:R:W117	6.35	1	No	Yes	5	5	2	1
R:R:W107	R:R:W117	8.43	1	Yes	Yes	8	5	2	1
R:R:C192	R:R:W107	5.22	1	Yes	Yes	9	8	2	2
R:R:C192	R:R:W117	3.92	1	Yes	Yes	9	5	2	1
L:L:?1	R:R:W117	8.11	1	Yes	Yes	0	5	0	1
R:R:D121	R:R:Y328	9.2	1	No	Yes	8	7	1	1
L:L:?1	R:R:D121	18.25	1	Yes	No	0	8	0	1
R:R:S173	R:R:V122	4.85	0	No	No	8	7	2	1
L:L:?1	R:R:V122	5.89	1	Yes	No	0	7	0	1
R:R:C125	R:R:W298	5.22	0	No	Yes	6	8	1	2
L:L:?1	R:R:C125	6.28	1	Yes	No	0	6	0	1
R:R:S169	R:R:T126	7.99	0	No	No	8	7	2	1
R:R:A208	R:R:T126	3.36	0	No	No	7	7	2	1
L:L:?1	R:R:T126	6.99	1	Yes	No	0	7	0	1
R:R:S204	R:R:Y200	17.8	0	No	No	6	7	1	2
L:L:?1	R:R:S204	3.56	1	Yes	No	0	6	0	1
R:R:F302	R:R:T205	6.49	1	Yes	No	6	6	1	2
R:R:F209	R:R:W298	6.01	1	Yes	Yes	8	8	2	2
R:R:F209	R:R:F302	16.08	1	Yes	Yes	8	6	2	1
R:R:F302	R:R:W298	5.01	1	Yes	Yes	6	8	1	2
R:R:F301	R:R:F302	3.22	1	No	Yes	7	6	1	1
R:R:F301	R:R:L324	3.65	1	No	No	7	5	1	1
L:L:?1	R:R:F301	8.67	1	Yes	No	0	7	0	1
L:L:?1	R:R:F302	6.74	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L324	10.95	1	Yes	No	0	5	0	1
R:R:W325	R:R:Y328	6.75	0	No	Yes	6	7	2	1
L:L:?1	R:R:Y328	5.56	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7UM7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.05
Number of Linked Nodes	229
Number of Links	246
Number of Hubs	26
Number of Links mediated by Hubs	111
Number of Communities	4
Number of Nodes involved in Communities	30
Number of Links involved in Communities	40

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	44414
Length Of Smallest Path	3
Average Path Length	14.6666
Length of Longest Path	31
Minimum Path Strength	1.24
Average Path Strength	5.36938
Maximum Path Strength	13.69
Minimum Path Correlation	0.7
Average Path Correlation	0.923218
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	43.2002
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.0475
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	H8D
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	H8D
Name	Methylergometrine
Synonyms	Methylergobasin
Identifier
Formula	C20 H25 N3 O2
Molecular Weight	339.431
SMILES
PubChem	8226
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	3
Total Bonds	53
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47898
Sequence	>7UM7_nogp_Chain_R G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R T F H R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G R R W Q L G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R P M E Y T L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G E E C Q V S R E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C S C D I P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N Y N S A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7UM6	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Lisuride	-	chim(NtGi1-Go)/β1/γ2	2.79	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7UM6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Lisuride	-		2.79	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7UM7	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Methylergometrine	-	chim(NtGi1-Go)/β1/γ2	2.75	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7UM7 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	Methylergometrine	-		2.75	2022-07-20	doi.org/10.1038/s41594-022-00796-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7UM7_nogp.zip

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