Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I96 3.4075405
2R:R:F100 11.51434
3R:R:N104 7.7525435
4R:R:V111 4.0275408
5R:R:F112 5.8875407
6R:R:L122 3.932549
7R:R:L143 5.025419
8R:R:H150 9.256518
9R:R:D154 8.628516
10R:R:W167 6.905619
11R:R:F169 14.2625417
12R:R:I180 6.3025415
13R:R:Q181 9.394516
14R:R:R199 6.7275409
15R:R:Y200 6.2125408
16R:R:E221 8.71406
17R:R:W226 7.144509
18R:R:E236 8.466515
19R:R:F240 9.495415
20R:R:M266 5.8875404
21R:R:L277 4.85416
22R:R:F278 7.89406
23R:R:F280 10.6225415
24R:R:F292 7.6725407
25R:R:F332 6.565419
26R:R:W336 9.565618
27R:R:L339 4.835416
28R:R:Y350 9.7875452
29R:R:R357 8.07455
30R:R:L364 4.035403
31R:R:Y369 10.31433
32R:R:N378 6.5625419
33R:R:Y387 8.3625467
34R:R:F393 8.084549
35R:R:F397 5.7925407
36L:L:?1 9.485331510
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:G92 R:R:I96 15.28461.76NoYes045
2R:R:I96 R:R:L365 10.6455.71YesNo053
3R:R:I96 R:R:V366 10.70674.61YesNo051
4R:R:L365 R:R:Y369 12.13435.86NoYes033
5R:R:S108 R:R:V159 11.00633.23NoNo077
6R:R:S108 R:R:S376 12.54411.63NoNo077
7R:R:S376 R:R:V111 14.0733.23NoYes078
8R:R:L377 R:R:V111 40.08642.98NoYes068
9R:R:L377 R:R:V107 38.71612.98NoNo065
10R:R:N373 R:R:V107 37.33710.35NoNo055
11R:R:N104 R:R:N373 35.949113.62YesNo055
12R:R:F100 R:R:N104 18.07817.25YesYes345
13R:R:F100 R:R:V366 13.6945.24YesNo041
14R:R:N104 R:R:Y369 15.06434.65YesYes353
15R:R:I155 R:R:V111 58.34513.07NoYes078
16R:R:L122 R:R:L386 13.82624.15YesNo499
17R:R:L328 R:R:L386 80.28295.54NoNo089
18R:R:L328 R:R:N382 81.39769.61NoNo089
19R:R:L143 R:R:N382 82.49474.12YesNo099
20R:R:D147 R:R:L143 97.66484.07NoYes199
21L:L:?1 R:R:D147 1007.21YesNo109
22L:L:?1 R:R:H150 75.264420.48YesYes108
23R:R:H150 R:R:I155 62.20925.3YesNo087
24R:R:F393 R:R:F397 26.36593.22YesYes097
25R:R:F393 R:R:L386 65.412417.05YesNo499
26R:R:I187 R:R:W226 13.707317.62NoYes079
27R:R:I187 R:R:I225 17.67274.42NoNo077
28R:R:I225 R:R:S191 23.52847.74NoNo078
29R:R:L143 R:R:S191 25.06616.01YesNo098
30R:R:F393 R:R:N137 50.53317.25YesNo098
31R:R:N134 R:R:N137 42.690314.98NoNo088
32R:R:N134 R:R:P136 41.08218.15NoNo088
33R:R:P136 R:R:R199 36.18265.76NoYes089
34R:R:L139 R:R:L195 17.74765.54NoNo079
35R:R:L195 R:R:V325 19.44848.94NoNo098
36R:R:R199 R:R:V325 21.16237.85YesNo098
37R:R:E221 R:R:L139 16.02936.63YesNo067
38R:R:D154 R:R:H150 17.157212.61YesYes168
39R:R:D154 R:R:I153 15.49175.6YesNo165
40R:R:D154 R:R:I180 27.37499.8YesYes165
41R:R:D154 R:R:V177 15.14367.3YesNo165
42L:L:?1 R:R:V177 16.40824.32YesNo105
43R:R:F169 R:R:W167 11.988914.03YesYes179
44R:R:K161 R:R:W167 21.89816.96NoYes059
45L:L:?1 R:R:K161 23.352112.93YesNo005
46L:L:?1 R:R:P178 33.64474.76YesNo105
47R:R:E236 R:R:P178 27.26476.29YesNo155
48R:R:E236 R:R:K182 27.51159.45YesNo154
49L:L:?1 R:R:K182 28.50729.53YesNo104
50R:R:F179 R:R:I180 16.66813.77NoYes065
51L:L:?1 R:R:L277 37.85256.01YesYes106
52L:L:?1 R:R:W336 60.975517.04YesYes108
53R:R:F332 R:R:W336 40.00711.02YesYes198
54R:R:F332 R:R:N378 45.20626.04YesYes199
55L:L:?1 R:R:N378 52.30883.98YesYes109
56R:R:F332 R:R:L192 76.71844.87YesNo098
57R:R:L192 R:R:V329 73.86764.47NoNo088
58R:R:F292 R:R:S196 30.30933.96YesNo079
59R:R:S196 R:R:T289 33.29226.4NoNo098
60R:R:T289 R:R:V329 36.26639.52NoNo088
61R:R:A202 R:R:R199 12.50884.15NoYes089
62R:R:F292 R:R:Y200 12.20487.22YesYes078
63R:R:E221 R:R:W217 10.76411.99YesNo065
64R:R:M300 R:R:V203 12.22686.09NoNo089
65R:R:M296 R:R:M300 15.26268.66NoNo088
66R:R:F326 R:R:M296 21.13593.73NoNo058
67R:R:F326 R:R:V329 36.00633.93NoNo058
68R:R:L277 R:R:Y281 11.1653.52YesNo166
69R:R:F265 R:R:P235 70.42214.33NoNo038
70R:R:P235 R:R:Y269 78.07112.52NoNo083
71R:R:E236 R:R:Y269 54.49428.98YesNo153
72R:R:K273 R:R:Y269 27.383710.75NoNo173
73R:R:K273 R:R:L277 28.90384.23NoYes176
74R:R:F265 R:R:M266 66.58443.73NoYes034
75R:R:M266 R:R:Q261 51.14569.52YesNo042
76R:R:I254 R:R:L256 19.84494.28NoNo044
77R:R:H258 R:R:L256 23.78833.86NoNo044
78R:R:H258 R:R:V260 31.64875.54NoNo043
79R:R:Q267 R:R:V260 35.56572.87NoNo013
80R:R:Q261 R:R:Q267 43.37335.12NoNo021
81R:R:F278 R:R:H340 13.79546.79YesNo068
82R:R:H340 R:R:W336 24.03517.41NoYes088
83R:R:F326 R:R:Y293 12.125518.57NoNo059
84R:R:A202 R:R:R318 10.7422.77NoNo087
85R:R:C327 R:R:V389 17.386310.25NoNo057
86R:R:C327 R:R:V331 19.35141.71NoNo056
87R:R:C335 R:R:V331 21.29891.71NoNo086
88R:R:C335 R:R:N378 22.26829.45NoYes089
89R:R:T324 R:R:V389 11.75544.76NoNo087
90R:R:F393 R:R:S390 10.97119.25YesNo098
91R:R:S390 R:R:T324 10.88746.4NoNo088
92L:L:?1 R:R:R343 39.80447.04YesNo106
93R:R:D368 R:R:R343 33.58314.29NoNo146
94R:R:L341 R:R:L367 29.25632.77NoNo065
95R:R:A342 R:R:L367 30.80284.73NoNo055
96R:R:A342 R:R:D368 32.33613.09NoNo054
97R:R:L341 R:R:L345 27.70536.92NoNo065
98R:R:L345 R:R:L364 26.14125.54NoYes053
99R:R:K346 R:R:L364 21.40911.41NoYes043
100R:R:K346 R:R:Y350 19.81852.39NoYes042
101R:R:R357 R:R:Y350 14.94549.26YesYes552
102R:R:D354 R:R:R357 10.067911.91NoYes015
103R:R:F397 R:R:Y387 12.54857.22YesYes077
104R:R:I153 R:R:V152 11.86993.07NoNo055
105R:R:D154 R:R:Q181 15.00267.83YesYes166
106L:L:?1 R:R:Q181 16.196724.42YesYes106
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D147 R:R:L143 4.07 1 No Yes 9 9 1 2
R:R:L143 R:R:T188 5.9 1 Yes No 9 9 2 2
R:R:D147 R:R:T188 5.78 1 No No 9 9 1 2
L:L:?1 R:R:D147 7.21 1 Yes No 0 9 0 1
R:R:D154 R:R:H150 12.61 1 Yes Yes 6 8 2 1
R:R:H150 R:R:I155 5.3 1 Yes No 8 7 1 2
R:R:H150 R:R:Q181 3.71 1 Yes Yes 8 6 1 1
R:R:H150 R:R:S184 4.18 1 Yes No 8 8 1 1
L:L:?1 R:R:H150 20.48 1 Yes Yes 0 8 0 1
R:R:I151 R:R:S379 6.19 0 No No 6 9 2 1
R:R:D154 R:R:V177 7.3 1 Yes No 6 5 2 1
R:R:D154 R:R:Q181 7.83 1 Yes Yes 6 6 2 1
R:R:N158 R:R:Q181 5.28 1 No Yes 7 6 1 1
L:L:?1 R:R:N158 7.95 1 Yes No 0 7 0 1
R:R:K161 R:R:W167 6.96 0 No Yes 5 9 1 2
L:L:?1 R:R:K161 12.93 1 Yes No 0 5 0 1
R:R:Q181 R:R:V177 5.73 1 Yes No 6 5 1 1
L:L:?1 R:R:V177 4.32 1 Yes No 0 5 0 1
R:R:E236 R:R:P178 6.29 1 Yes No 5 5 2 1
R:R:F240 R:R:P178 15.89 1 Yes No 5 5 2 1
L:L:?1 R:R:P178 4.76 1 Yes No 0 5 0 1
L:L:?1 R:R:Q181 24.42 1 Yes Yes 0 6 0 1
R:R:E236 R:R:K182 9.45 1 Yes No 5 4 2 1
R:R:K182 R:R:L277 5.64 1 No Yes 4 6 1 1
L:L:?1 R:R:K182 9.53 1 Yes No 0 4 0 1
L:L:?1 R:R:S184 4.35 1 Yes No 0 8 0 1
R:R:V185 R:R:W336 7.36 1 No Yes 7 8 1 1
L:L:?1 R:R:V185 7.91 1 Yes No 0 7 0 1
R:R:E236 R:R:F240 8.16 1 Yes Yes 5 5 2 2
R:R:E236 R:R:K273 9.45 1 Yes No 5 7 2 2
R:R:K273 R:R:L277 4.23 1 No Yes 7 6 2 1
L:L:?1 R:R:L277 6.01 1 Yes Yes 0 6 0 1
R:R:F332 R:R:W336 11.02 1 Yes Yes 9 8 2 1
R:R:F332 R:R:N378 6.04 1 Yes Yes 9 9 2 1
R:R:C335 R:R:N378 9.45 0 No Yes 8 9 2 1
R:R:H340 R:R:W336 7.41 0 No Yes 8 8 2 1
R:R:A375 R:R:W336 7.78 0 No Yes 8 8 2 1
R:R:N378 R:R:W336 6.78 1 Yes Yes 9 8 1 1
L:L:?1 R:R:W336 17.04 1 Yes Yes 0 8 0 1
R:R:L339 R:R:R343 7.29 1 Yes No 6 6 2 1
R:R:D368 R:R:L339 4.07 1 No Yes 4 6 2 2
R:R:D368 R:R:R343 14.29 1 No No 4 6 2 1
L:L:?1 R:R:R343 7.04 1 Yes No 0 6 0 1
L:L:?1 R:R:N378 3.98 1 Yes Yes 0 9 0 1
L:L:?1 R:R:S379 4.35 1 Yes No 0 9 0 1
R:R:L277 R:R:Y281 3.52 1 Yes No 6 6 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
50.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
50.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
50.00Consensusendothelin_offOrthosteric Ligandetb_off
50.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
47.37Single4DJHJDTic4DJH-κ-JDTic
47.37Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
45.00Single5X33BIIL2605X33-BLT1-BIIL260
44.44Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
44.44Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
43.48Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
42.86Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
42.86Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
42.11Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
42.11Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
42.11Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
41.18Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
40.91Single6PT3DPI-2876PT3-δ-DPI-287
40.91Single8X5YAstemizole8X5Y-H1-Astemizole
40.00Single5X93K-87945X93-ETB-K-8794
40.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
40.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
40.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
40.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
40.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
40.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
39.13Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
38.89Single6TPNHTL66416TPN-OX2-HTL6641
38.89Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.89Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
38.89Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
38.10Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
38.10Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
38.10Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
38.10Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Single7YITNalfurafine7YIT-κ-Nalfurafine
38.10Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
38.10Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
38.10Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
38.10Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
37.50Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
37.50Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
36.84Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
36.84Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
36.84Single6TOTLemborexant6TOT-OX1-Lemborexant
36.84Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
36.84Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
36.36Single5CGDHTL142425CGD-mGlu5-HTL14242
36.36Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
36.36Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
36.36Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
36.36Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.36Consensusorexin_onOrthosteric Ligandox2_on
36.36Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.00Single5CGCHTL142425CGC-mGlu5-HTL14242
35.00Single5WIUNemonapride5WIU-D4-Nemonapride
35.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
35.00Single5XPRBosentan5XPR-ETB-Bosentan
35.00Single6TP6Filorexant6TP6-OX1-Filorexant
35.00Single7C4SS1P7C4S-S1P3-S1P
35.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
35.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
35.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
35.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
35.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
34.78Single5ZTYAM102575ZTY-CB2-AM10257
34.78Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
34.78Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
34.78Consensuslpl_offOrthosteric Ligands1p_off lpa_off
34.78Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
34.62Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
34.62Single7C61Ergotamine7C61-5-HT1B-Ergotamine
33.33Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
33.33Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
33.33Single5DHHSB-6121115DHH-NOP-SB-612111
33.33Single6AKXA4R6AKX-CCR5-A4R
33.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
33.33Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
33.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
33.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
33.33Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
33.33Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
33.33Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
33.33Single7XRRLemborexant7XRR-OX2-Lemborexant
33.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
33.33Single8IHKAcifran8IHK-HCA3-Acifran
33.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
33.33Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
33.33Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
33.33Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
33.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
33.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
32.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
32.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
31.82Single4AMIBucindolol4AMI-β1-Bucindolol
31.82Single4LDEBI1671074LDE-β2-BI167107
31.82Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
31.82Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
31.82Single6ZG4HTL00099366ZG4-M1-HTL0009936
31.82Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
31.82Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
31.82Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.82Single8JJLOlodaterol8JJL-β2-Olodaterol
31.82Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
31.82Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
31.58Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
31.58Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
31.58Single4MBSMaraviroc4MBS-CCR5-Maraviroc
31.58Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
31.58Single4ZJCSB-6740424ZJC-OX1-SB-674042
31.58Single6IQLL7458706IQL-D4-L745870
31.58Single6TPGEMPA6TPG-OX2-EMPA
31.58Single6ZG9GSK10347026ZG9-M1-GSK1034702
31.58Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
31.58Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
31.58Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
31.58Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
31.58Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
31.58Consensus5ht5_onOrthosteric Ligand5ht5a_on
31.58Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
31.58Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
31.58Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
31.58Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
31.58Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
31.58Consensuss1p_offOrthosteric Ligands1p1_off
31.25Single6TQ9SB-4081246TQ9-OX1-SB-408124
30.77Single6PT2KGCHM076PT2-δ-KGCHM07
30.77Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
30.77Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
30.77Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
30.77Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
30.43Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
30.43Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
30.43Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
30.43Single6H7LDobutamine6H7L-β1-Dobutamine
30.43Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
30.43Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
30.43Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
30.43Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
30.43Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
30.43Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
30.43Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
30.43Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.43Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single2Y04Salbutamol2Y04-β1-Salbutamol
30.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
30.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
30.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
30.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
30.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
30.00Single6FFHFenobam6FFH-mGlu5-Fenobam
30.00Single6IGLIRL16206IGL-ETB-IRL1620
30.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
30.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
30.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
30.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
30.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
30.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
30.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
30.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
30.00Single7UL4Alvimopan7UL4-μ-Alvimopan
30.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
30.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
30.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
30.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
30.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
30.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
30.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
30.00Single8X64Desloratadine8X64-H1-Desloratadine
30.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
30.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
30.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
30.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
30.00Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
30.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
30.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
29.63Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
29.17Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
29.17Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Consensusclass-d_offOrthosteric Ligandste2_off
29.17Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
29.17Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
29.17Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
29.17Consensuslpl_onOrthosteric Ligands1p_on lpa_on
29.03Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.03Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
28.57Single2Y03Isoprenaline2Y03-β1-Isoprenaline
28.57Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
28.57Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
28.57Single5C1MBU725C1M-μ-BU72
28.57Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
28.57Single5TVNLSD5TVN-5-HT2B-LSD
28.57Single5WQCEMPA5WQC-OX2-EMPA
28.57Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
28.57Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
28.57Single6E67BI1671076E67-β2-BI167107-Gs (fused)
28.57Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
28.57Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
28.57Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
28.57Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
28.57Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
28.57Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
28.57Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
28.57Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
28.57Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
28.57Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
28.57Single7WC6LSD7WC6-5-HT2A-LSD
28.57Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.57Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
28.57Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
28.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
28.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
28.57Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
28.57Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
28.57Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
28.57Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
28.57Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
28.57Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
28.57Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
28.57Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
28.57Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
28.57Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
28.57Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
28.57Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
28.12Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
28.00Single7QA8Peptide7QA8-STE2-Peptide
28.00Single7QA8Peptide7QA8-STE2-Peptide
28.00Consensusclass-d_offOrthosteric Ligandste2_off
28.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
28.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
27.78Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
27.78Single6TP4ACT-4622066TP4-OX1-ACT-462206
27.78Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
27.78Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
27.78Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
27.78Single8GH1Epinephrine8GH1-β2-Epinephrine
27.78Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
27.78Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
27.59Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
27.27Single2YDVNECA2YDV-A2A-NECA
27.27Single3P0GBI1671073P0G-β2-BI167107
27.27Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
27.27Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
27.27Single4RWADIPP-NH24RWA-δ-DIPP-NH2
27.27Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
27.27Single4UHRCGS216804UHR-A2A-CGS21680
27.27Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
27.27Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
27.27Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
27.27Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
27.27Single5G53NECA5G53-A2A-NECA-Gs
27.27Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
27.27Single6E59L-7607356E59-NK1-L-760735
27.27Single6J20Aprepitant6J20-NK1-Aprepitant
27.27Single6J21Aprepitant6J21-NK1-Aprepitant
27.27Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
27.27Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
27.27Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.27Single6WGTLSD6WGT-5-HT2A-LSD
27.27Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
27.27Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
27.27Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
27.27Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
27.27Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
27.27Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
27.27Single7P2L4YI7P2L-mGlu5-4YI
27.27Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
27.27Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
27.27Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
27.27Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
27.27Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
27.27Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
27.27Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
27.27Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
27.27Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
27.27Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
27.27Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
27.27Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
27.27Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
27.27Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
27.27Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
27.27Consensushistamine_offOrthosteric Ligandh1_off
27.27Consensuslpa_offOrthosteric Ligandlpa1_off
27.27Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
27.27Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
27.27Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
26.92Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
26.92Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
26.32Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
26.32Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
26.32Single5WS3EMPA5WS3-OX2-EMPA
26.32Single6AKYMaraviroc6AKY-CCR5-Maraviroc
26.32Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
26.32Single6TODEMPA6TOD-OX1-EMPA-Na
26.32Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.32Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
26.32Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
26.32Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
26.32Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
26.32Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
26.32Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.32Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
26.32Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
26.32Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
26.32Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
26.32Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
26.32Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
26.32Consensusalpha1_onOrthosteric Ligandalpha1a_on
26.32Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
26.32Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
26.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.09Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
26.09Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
26.09Single6HLPNetupitant6HLP-NK1-Netupitant
26.09Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
26.09Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
26.09Single7DFPSpiperone7DFP-D2-Spiperone
26.09Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
26.09Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
26.09Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
26.09Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.09Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
26.09Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
26.09Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
26.09Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
26.09Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single8JJ8Formoterol8JJ8-β2-Formoterol
26.09Single8JWZAB9288JWZ-A2A-AB928-Na
26.09Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
26.09Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
26.09Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
26.09Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
26.09Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
26.09Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
26.09Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
26.09Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
26.09Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
26.09Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
26.09Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
26.09Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
25.93Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
25.81Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.81Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
25.81Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
25.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
25.00Single3RZECidoxepin3RZE-H1-Cidoxepin
25.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
25.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single6A94Zotepine6A94-5-HT2A-Zotepine
25.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
25.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
25.00Single6IBLArformoterol6IBL-β1-Arformoterol
25.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
25.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
25.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
25.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
25.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
25.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
25.00Single6TPKRetosiban6TPK-OT-Retosiban
25.00Single6VI4JDTic6VI4-κ-JDTic
25.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
25.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
25.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
25.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
25.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
25.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
25.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
25.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
25.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
25.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
25.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
25.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
25.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
25.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
25.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GGKEpinephrine8GGK-β2-Epinephrine
25.00Single8GGLEpinephrine8GGL-β2-Epinephrine
25.00Single8GGMEpinephrine8GGM-β2-Epinephrine
25.00Single8GGPEpinephrine8GGP-β2-Epinephrine
25.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
25.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
25.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
25.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
25.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
25.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
25.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
25.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
25.00Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
25.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
25.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.00Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
25.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
25.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
24.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
24.14Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single3NY9PubChem 9131033NY9-β2-PubChem 913103
24.00Single4UG2CGS216804UG2-A2A-CGS21680
24.00Single7SK9CCX6627SK9-ACKR3-CCX662
24.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
24.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
24.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
24.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
24.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
24.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
24.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
23.81Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
23.81Single2Y02Carmoterol2Y02-β1-Carmoterol
23.81Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
23.81Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
23.81Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
23.81Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
23.81Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
23.81Single6DRXLisuride6DRX-5-HT2B-Lisuride
23.81Single6H7MSalbutamol6H7M-β1-Salbutamol
23.81Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
23.81Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
23.81Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
23.81Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
23.81Single7BU7BI1671077BU7-β1-BI167107
23.81Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
23.81Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
23.81Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
23.81Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
23.81Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
23.81Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
23.81Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
23.81Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
23.81Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
23.81Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
23.81Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.81Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.81Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
23.81Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
23.81Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
23.81Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GGJEpinephrine8GGJ-β2-Epinephrine
23.81Single8GGNEpinephrine8GGN-β2-Epinephrine
23.81Single8GGOEpinephrine8GGO-β2-Epinephrine
23.81Single8GGUEpinephrine8GGU-β2-Epinephrine
23.81Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.81Single8JJOAlprenolol8JJO-β2-Alprenolol
23.81Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
23.81Single8K5DGSK2560738K5D-HCA2-GSK256073
23.81Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
23.81Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
23.81Single8X63Mepyramine8X63-H1-Mepyramine
23.81Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
23.81Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
23.81Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
23.81Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
23.81Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
23.81Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
23.81Consensusblt_onOrthosteric Ligandblt1_on
23.81Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
23.81Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
23.81Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
23.81Consensusgi_hcarOrthosteric Ligandgi_hca
23.81Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
23.81Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.81Consensusleuko_onOrthosteric Ligandblt_on
23.81Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
23.81Consensustachykinin_offOrthosteric Ligandnk1_off
23.81Consensustar_onOrthosteric Ligandta1_on
23.53Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
23.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
23.33Consensusclass-d_onOrthosteric Ligandste2_on
23.08Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
23.08Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
23.08Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
23.08Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.08Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
23.08Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.08Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
23.08Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
23.08Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.08Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
22.86Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.73Single2Y00Dobutamine2Y00-β1-Dobutamine
22.73Single6LUQHaloperidol6LUQ-D2-Haloperidol
22.73Single6PS6Timolol6PS6-β2-Timolol
22.73Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
22.73Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
22.73Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
22.73Single7XKAEpinephrine7XKA-β2-Epinephrine
22.73Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
22.73Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
22.73Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
22.73Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.73Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
22.73Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
22.73Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
22.73Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
22.73Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.58Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
22.58Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
22.58Consensusendothelin_onOrthosteric Ligandetb_on eta_on
22.58Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
22.58Consensusgi_class-dOrthosteric Ligandgi_ste
22.58Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
22.22Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
22.22Single3OE6IT1t3OE6-CXCR4-IT1t
22.22Single3OE8IT1t3OE8-CXCR4-IT1t
22.22Single6HLOAprepitant6HLO-NK1-Aprepitant
22.22Single7WC5Psilocin7WC5-5-HT2A-Psilocin
22.22Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
22.22Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
22.22Single8GGREpinephrine8GGR-β2-Epinephrine
22.22Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
21.88Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
21.88Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.88Single8IY6Endothelin-18IY6-ETB-Endothelin-1
21.88Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
21.74Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
21.74Single4U15Tiotropium4U15-M3-Tiotropium
21.74Single5V54Methiothepin5V54-5-HT1B-Methiothepin
21.74Single5XR8AM8415XR8-CB1-AM841
21.74Single5XRAAM115425XRA-CB1-AM11542
21.74Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
21.74Single6OL9Tiotropium6OL9-M5-Tiotropium
21.74Single7B6WCyclazosin7B6W-α1b-Cyclazosin
21.74Single7EPENAM5637EPE-mGlu-NAM563
21.74Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
21.74Single7TUYGSK682753A7TUY-GPR183-GSK682753A
21.74Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.74Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.74Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
21.74Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
21.74Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
21.74Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
21.74Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.74Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
21.74Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
21.74Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
21.74Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
21.74Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
21.74Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
21.74Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
21.74Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
21.74Consensus5ht1_offOrthosteric Ligand5ht1b_off
21.74Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
21.74Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
21.74Consensus5ht5_offOrthosteric Ligand5ht5a_off
21.74Consensusa2_onOrthosteric Liganda2a_on a2b_on
21.74Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
21.74Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
21.74Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
21.74Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
21.74Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.74Consensuslpa_onOrthosteric Ligandlpa1_on
21.74Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
21.74Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
21.74Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
21.43Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
21.43Consensusangiotensin_onOrthosteric Ligandat1_on
21.43Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
21.43Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
21.43Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
21.21Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.05Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
21.05Single3OE9IT1t3OE9-CXCR4-IT1t
21.05Single3PBLEticlopride3PBL-D3-Eticlopride
21.05Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
21.05Single6HLLCP999946HLL-NK1-CP99994
21.05Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
21.05Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
21.05Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
21.05Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
21.05Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
21.05Single7SRQLSD7SRQ-5-HT2B-LSD
21.05Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
21.05Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
21.05Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
21.05Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GGSEpinephrine8GGS-β2-Epinephrine
21.05Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
21.05Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
21.05Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
21.05Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
21.05Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
21.05Consensusclass-t_onOrthosteric Ligandtaste2_on
21.05Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
21.05Consensusgs_class-tOrthosteric Ligandgs_taste
21.05Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
21.05Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
21.05Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
20.83Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
20.83Single5CXVTiotropium5CXV-M1-Tiotropium
20.83Single6A93Risperidone6A93-5-HT2A-Risperidone
20.83Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
20.83Single6MXTSalmeterol6MXT-β2-Salmeterol
20.83Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
20.83Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.83Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
20.83Single7K15MKD0467K15-BLT1-MKD046-Na
20.83Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.83Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
20.83Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.83Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
20.83Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
20.83Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
20.83Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
20.83Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
20.83Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
20.83Single8WU1KCA8WU1-CB1-KCA-Arrestin1
20.83Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
20.83Consensusblt_offOrthosteric Ligandblt1_off
20.83Consensusgi_class-fOther Ligandgi_frizzled
20.83Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.83Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.83Consensusgs_steroidOrthosteric Ligandgs_bileacid
20.83Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
20.83Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.69Single6JODAngiotensin II6JOD-AT2-Angiotensin II
20.69Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
20.69Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
20.69Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
20.69Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
20.69Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
20.69Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.59Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
20.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
20.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
20.00Single3ODUIT1t3ODU-CXCR4-IT1t
20.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
20.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.00Single6KUXRS-799486KUX-α2a-RS-79948
20.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
20.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
20.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
20.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
20.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
20.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
20.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
20.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
20.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
20.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
20.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
20.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
20.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
20.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
20.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
20.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
20.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
20.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
20.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGVEpinephrine8GGV-β2-Epinephrine
20.00Single8GGWEpinephrine8GGW-β2-Epinephrine
20.00Single8GGXEpinephrine8GGX-β2-Epinephrine
20.00Single8GH0Epinephrine8GH0-β2-Epinephrine
20.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
20.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
20.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
20.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.00Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
20.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
20.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
20.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
20.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
20.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
20.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
20.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
20.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
20.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
20.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgt_class-aOrthosteric Ligandgt_opsin
20.00Consensusgt_opsinOrthosteric Ligandgt_sensory
20.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
20.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
20.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
20.00Consensussteroid_onOrthosteric Ligandbileacid_on
19.44Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.44Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.44Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
19.44Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
19.35Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
19.35Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
19.35Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.35Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.35Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
19.35Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
19.35Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
19.35Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
19.23Single5EE7MK08935EE7-Glucagon-MK0893
19.23Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
19.23Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.23Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single7XN9L-054,5227XN9-SST2-L-054,522
19.23Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
19.23Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
19.23Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
19.05Single2YDOAdenosine2YDO-A2A-Adenosine
19.05Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
19.05Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
19.05Single6DS0Ly2660976DS0-5-HT2B-Ly266097
19.05Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
19.05Single6V9SGTPL114036V9S-OX1-GTPL11403
19.05Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
19.05Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
19.05Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
19.05Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
19.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
19.05Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
19.05Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
19.05Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GGIEpinephrine8GGI-β2-Epinephrine
19.05Single8GGTEpinephrine8GGT-β2-Epinephrine
19.05Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
19.05Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
19.05Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
19.05Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
19.05Single8K5CAcipimox8K5C-HCA2-Acipimox
19.05Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
19.05Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
19.05Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
19.05Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
19.05Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
19.05Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Consensushca_onOrthosteric Ligandhca2_on hca3_on
19.05Consensushcar_onOrthosteric Ligandhca_on
19.05Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
19.05Consensussensory_offOrthosteric Ligandopsin_off
18.92Consensuspth_onOrthosteric Ligandpth1_on pth2_on
18.75Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
18.75Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
18.75Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
18.75Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.75Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single4IARErgotamine4IAR-5-HT1B-Ergotamine
18.52Single4XT1Fractalkine4XT1-US28-Fractalkine
18.52Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
18.52Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
18.52Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
18.52Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.52Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
18.52Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.52Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
18.52Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.52Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
18.18Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
18.18Single2Y01Dobutamine2Y01-β1-Dobutamine
18.18Single4DAJTiotropium4DAJ-M3-Tiotropium
18.18Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
18.18Single4MQSIperoxo4MQS-M2-Iperoxo
18.18Single4U14Tiotropium4U14-M3-Tiotropium
18.18Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
18.18Single4YAYZD-71554YAY-AT1-ZD-7155
18.18Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
18.18Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
18.18Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
18.18Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
18.18Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
18.18Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
18.18Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
18.18Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.18Single6GPSMK08126GPS-CCR2-MK0812
18.18Single6IIVDaltroban6IIV-TP-Daltroban
18.18Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
18.18Single6PS1Timolol6PS1-β2-Timolol
18.18Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
18.18Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
18.18Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
18.18Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
18.18Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
18.18Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
18.18Single8CU6LJ-45178CU6-A2A-LJ-4517
18.18Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
18.18Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
18.18Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
18.18Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
18.18Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
18.18Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Consensusadenosine_onOrthosteric Liganda1_on a2_on
18.18Consensuscck_offOrthosteric Ligandccka_off
18.18Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
18.18Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
18.18Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
18.18Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Consensushistamine_onOrthosteric Ligandh1_on h4_on
18.18Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
18.18Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
18.18Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
18.18Consensusnucleotide_onOrthosteric Ligandadenosine_on
18.18Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
17.95Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
17.95Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.86Single3QAKUK-4320973QAK-A2A-UK-432097
17.86Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
17.86Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
17.86Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
17.86Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
17.86Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.86Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.86Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
17.86Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
17.86Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.86Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
17.65Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
17.65Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
17.65Single7WC4Serotonin7WC4-5-HT2A-Serotonin
17.65Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
17.65Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
17.39Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
17.39Single5N2SPSB365N2S-A1-PSB36
17.39Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
17.39Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
17.39Single6D26Fevipiprant6D26-DP2-Fevipiprant
17.39Single6GPXMK08126GPX-CCR2-MK0812
17.39Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
17.39Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
17.39Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
17.39Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.39Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
17.39Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
17.39Single7SINNPS-21437SIN-CaS-NPS-2143
17.39Single7SINNPS-21437SIN-CaS-NPS-2143
17.39Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
17.39Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
17.39Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
17.39Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
17.39Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
17.39Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
17.39Single7YXAONO-54306087YXA-S1P5-ONO-5430608
17.39Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8EA0Iperoxo8EA0-M3-Iperoxo
17.39Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
17.39Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
17.39Single8QOTNanobody E8QOT-μ-Nanobody E
17.39Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
17.39Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
17.39Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
17.39Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.39Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.39Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
17.39Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.24Single5WF5UK-4320975WF5-A2A-UK-432097
17.24Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
17.24Single6W25SHU91196W25-MC4-SHU9119-Ca
17.24Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
17.24Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
17.24Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.24Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
17.24Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.14Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
17.14Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
16.67Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
16.67Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
16.67Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
16.67Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
16.67Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
16.67Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.67Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
16.67Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
16.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
16.67Single7W41PD1762527W41-BB2-PD176252
16.67Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
16.67Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
16.67Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
16.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
16.67Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
16.67Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
16.67Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
16.67Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
16.67Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
16.67Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
16.67Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
16.67Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
16.67Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
16.67Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.67Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
16.67Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
16.67Consensusbombesin_offOrthosteric Ligandbb2_off
16.67Consensuscck_onOrthosteric Ligandccka_on cckb_on
16.67Consensusclass-d_onOrthosteric Ligandste2_on
16.67Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.67Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
16.67Consensusgi_class-dOrthosteric Ligandgi_ste
16.67Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
16.67Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
16.67Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
16.67Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
16.67Consensusrelaxin_onOrthosteric Ligandrxfp4_on
16.67Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.67Consensussensory_onOrthosteric Ligandopsin_on
16.22Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
16.22Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
16.13Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
16.13Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
16.13Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.13Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.13Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.13Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.13Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.13Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
16.13Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
16.13Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.13Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
16.13Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.00Single6CM4Risperidone6CM4-D2-Risperidone
16.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
16.00Single6IIURamatroban6IIU-TP-Ramatroban
16.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
16.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
16.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
16.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
16.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
16.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
16.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
16.00Consensuschemokine_offOrthosteric Ligandcxcr_off
16.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
16.00Consensuscxcr_offOrthosteric Ligandcxcr4_off
16.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
16.00Consensusdp_offOrthosteric Liganddp2_off
16.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
16.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
16.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
16.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
16.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
15.79Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
15.79Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
15.79Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
15.79Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
15.79Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.79Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
15.79Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8GGZEpinephrine8GGZ-β2-Epinephrine
15.79Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.79Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
15.79Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
15.79Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.79Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.62Single4XT3Fractalkine4XT3-US28-Fractalkine
15.62Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
15.62Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
15.62Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
15.62Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
15.62Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
15.62Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
15.38Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
15.38Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
15.38Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
15.38Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
15.38Single7EZCUKA7EZC-A2A-UKA
15.38Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
15.38Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
15.38Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
15.38Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
15.38Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
15.38Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
15.38Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
15.38Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.38Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
15.15Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.15Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Consensusgo_class-b1Orthosteric Ligandgo_crf
15.15Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
15.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
15.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
15.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
15.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
15.00Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
15.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8GGYEpinephrine8GGY-β2-Epinephrine
15.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
15.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
15.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
15.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8K5BNiacin8K5B-HCA2-Niacin
15.00Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.00Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
15.00Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
14.81Single5WF6UK-4320975WF6-A2A-UK-432097
14.81Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
14.81Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
14.81Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
14.81Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
14.81Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
14.81Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
14.81Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.81Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
14.81Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
14.81Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.71Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
14.71Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
14.71Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.71Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
14.29Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
14.29Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
14.29Single6ME2Ramelteon6ME2-MT1-Ramelteon
14.29Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
14.29Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
14.29Single7BR3Elagolix7BR3-GnRH1-Elagolix
14.29Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
14.29Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
14.29Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
14.29Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.29Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
14.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
14.29Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
14.29Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8IWESpermidine8IWE-TAAR9-Spermidine
14.29Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
14.29Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
14.29Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
14.29Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
14.29Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
14.29Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
14.29Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
14.29Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
14.29Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.29Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.89Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.79Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
13.79Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
13.79Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
13.79Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
13.64Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
13.64Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.64Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
13.64Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
13.64Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
13.64Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
13.64Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
13.64Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
13.64Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
13.64Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
13.64Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
13.64Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
13.64Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
13.64Consensusgnrh_offOrthosteric Ligandgnrh1_off
13.64Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
13.51Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
13.33Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.33Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
13.33Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
13.33Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
13.16Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.04Single5DSGTiotropium5DSG-M4-Tiotropium
13.04Single5TGZAM65385TGZ-CB1-AM6538
13.04Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
13.04Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
13.04Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.04Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
13.04Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
13.04Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
13.04Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
13.04Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
13.04Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
13.04Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.04Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
13.04Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
13.04Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.04Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
13.04Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
13.04Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
13.04Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
13.04Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.04Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.04Consensushcar_offOrthosteric Ligandsuccinate_off
13.04Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
13.04Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
13.04Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
13.04Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
13.04Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
12.90Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
12.90Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.90Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.90Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single4NTJAZD12834NTJ-P2Y12-AZD1283
12.50Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
12.50Single5NM2ZM2413855NM2-A2A-ZM241385-Na
12.50Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
12.50Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
12.50Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
12.50Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
12.50Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
12.50Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
12.50Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
12.50Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
12.50Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
12.50Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
12.50Single8GNEKW-63568GNE-A2A-KW-6356-Na
12.50Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.50Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
12.50Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
12.50Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
12.50Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
12.50Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
12.50Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.12Single6FJ3PTH6FJ3-PTH1-PTH
12.12Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.12Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
12.12Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.12Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
12.12Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Single7SK3CXCL127SK3-ACKR3-CXCL12
12.12Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
12.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
12.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
12.00Single6OS1TRV0266OS1-AT1-TRV026
12.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
12.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
12.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
12.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
12.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
12.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
12.00Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
12.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
12.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
12.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
11.76Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
11.76Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
11.76Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
11.76Single6W25Ca6W25-MC4-SHU9119-Ca
11.76Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
11.76Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
11.76Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
11.76Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
11.76Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
11.54Single4N4WSANT-14N4W-SMO-SANT-1
11.54Single4PY02MeSATP4PY0-P2Y12-2MeSATP
11.54Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
11.54Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
11.54Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
11.54Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
11.54Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
11.54Single8GTMBMK-C2038GTM-CRF1-BMK-C203
11.54Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
11.54Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
11.54Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.54Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
11.54Consensusclass-b2_onOrthosteric Ligandadgrg_on
11.54Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
11.43Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
11.43Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
11.43Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
11.43Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
11.43Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
11.43Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
11.43Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
11.43Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
11.36Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
11.11Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
11.11Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
11.11Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.11Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.11Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
11.11Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
11.11Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
11.11Consensusclass-c_onOther Ligandgabab_on mglu_on
11.11Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
11.11Consensuscyslt_offOrthosteric Ligandcyslt2_off
11.11Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.11Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.81Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
10.81Consensusglp_onOrthosteric Ligandglp1_on glp2_on
10.71Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
10.71Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
10.71Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
10.71Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
10.71Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
10.71Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
10.71Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusgs_class-b2Orthosteric Ligandgs_adgr
10.53Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
10.53Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
10.53Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
10.53Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
10.34Single7F8XNN90567F8X-CCKA-NN9056
10.34Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
10.34Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
10.26Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.26Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
10.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
10.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
10.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
10.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
10.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
10.00Single7SK5CXCL127SK5-ACKR3-CXCL12
10.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
10.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
10.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
10.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
10.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
10.00Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
10.00Consensussst_offOrthosteric Ligandsst2_off
9.68Single3OE0CVX153OE0-CXCR4-CVX15
9.68Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
9.68Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
9.68Single7XNACYN1548067XNA-SST2-CYN154806
9.68Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
9.68Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
9.68Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
9.68Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
9.52Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
9.52Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
9.52Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
9.52Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
9.52Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.52Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
9.52Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
9.52Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
9.52Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
9.52Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
9.52Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
9.52Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.52Consensusgo_class-b2Orthosteric Ligandgo_adhesion
9.52Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.38Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
9.38Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
9.38Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
9.38Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.38Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
9.30Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
9.09Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
9.09Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
9.09Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
9.09Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
9.09Single5U09Taranabant5U09-CB1-Taranabant
9.09Single5ZKQABT-4915ZKQ-PAF-ABT-491
9.09Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.09Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.09Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
9.09Single7F8ULintitript7F8U-CCKA-Lintitript
9.09Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
9.09Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
9.09Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
9.09Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.09Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
9.09Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8GNGIstradefylline8GNG-A2A-Istradefylline
9.09Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
9.09Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
9.09Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
9.09Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
9.09Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
9.09Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
8.82Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
8.82Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
8.82Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single5IU7Q274563465IU7-A2A-Q27456346-Na
8.70Single5JTBZM2413855JTB-A2A-ZM241385
8.70Single5K2BZM2413855K2B-A2A-ZM241385-Na
8.70Single5UVIZM2413855UVI-A2A-ZM241385
8.70Single6AQFZM2413856AQF-A2A-ZM241385
8.70Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
8.70Single6MH8ZM2413856MH8-A2A-ZM241385
8.70Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
8.70Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
8.70Single6ZINSR486926ZIN-NTS1-SR48692
8.70Single7AROLUF58337ARO-A2A-LUF5833-Na
8.70Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.70Single7T32ZM2413857T32-A2A-ZM241385
8.70Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
8.70Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
8.70Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
8.70Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
8.70Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
8.70Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
8.70Single8K2WAMG4878K2W-CXCR3-AMG487
8.70Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
8.70Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
8.70Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
8.57Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
8.57Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
8.57Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
8.57Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
8.33Single3EMLZM2413853EML-A2A-ZM241385
8.33Single4EIYZM2413854EIY-A2A-ZM241385-Na
8.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
8.33Single5K2AZM2413855K2A-A2A-ZM241385-Na
8.33Single5OLGZM2413855OLG-A2A-ZM241385-Na
8.33Single5UENDU1725UEN-A1-DU172
8.33Single5VRAZM2413855VRA-A2A-ZM241385-Na
8.33Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
8.33Single6D27CAY104716D27-DP2-CAY10471
8.33Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
8.33Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
8.33Single6LMLGlucagon6LML-Glucagon-Glucagon
8.33Single6S0LZM2413856S0L-A2A-ZM241385
8.33Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
8.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
8.33Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.33Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
8.33Single7PYRPSB-21157PYR-A2A-PSB-2115
8.33Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
8.33Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
8.33Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.33Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
8.33Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
8.33Consensusa2_offOrthosteric Liganda2a_off
8.33Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
8.33Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
8.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
8.11Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.11Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
8.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
8.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
8.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
8.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
8.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
8.00Single6S0QZM2413856S0Q-A2A-ZM241385
8.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
8.00Single6Z4SSR486926Z4S-NTS1-SR48692
8.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
8.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
8.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
8.00Consensusep_offOrthosteric Ligandep4_off
7.89Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single5TZR-5TZR-FFA1 (GPR40)-MK8666
7.69Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
7.69Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7PX4PSB-21137PX4-A2A-PSB-2113
7.69Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
7.69Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
7.69Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.69Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensuschemerin_onOrthosteric Ligandcml1_on
7.69Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
7.69Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.41Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
7.41Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.41Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.41Single4XESNeurotensin4XES-NTS1-Neurotensin
7.41Single6OS2TRV0266OS2-AT1-TRV026
7.41Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
7.41Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
7.41Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.41Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
7.41Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
7.41Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
7.41Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.41Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
7.41Consensusnts_offOrthosteric Ligandnts1_off
7.41Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.32Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
7.14Single4BUONeurotensin4BUO-NTS1-Neurotensin
7.14Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.14Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
7.14Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.90Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
6.90Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.90Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
6.82Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
6.67Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
6.67Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
6.67Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
6.67Consensusclass-c_offOther Ligandgabab_off mglu_off
6.45Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
6.45Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.45Single7SHEPI; PE7SHE-GPR158-PI; PE
6.45Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.45Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.45Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
6.38Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
6.06Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.88Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
5.88Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
5.88Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
5.88Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
5.71Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
5.71Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
5.71Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
5.56Single5MZPCaffeine5MZP-A2A-Caffeine-Na
5.56Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
5.56Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.41Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
5.26Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
5.26Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
5.26Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.26Single8PWNTheophylline8PWN-A2A-Theophylline
5.26Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
5.26Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.13Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.13Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.00Single3RFMCaffeine3RFM-A2A-Caffeine
5.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.00Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
5.00Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.00Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
4.88Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
4.76Single3UZAGTPL92363UZA-A2A-GTPL9236
4.76Single6LI0GTPL98046LI0-GPR52-GTPL9804
4.76Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
4.76Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
4.76Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
4.76Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
4.76Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.76Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.65Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
4.55Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
4.55Single7FEEZCZ0117FEE-CB1-PubMed 104895-ZCZ011
4.55Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.55Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
4.55Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
4.35Single3PWHZM2413853PWH-A2A-ZM241385
4.35Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.35Single4XNVBPTU4XNV-P2Y1-BPTU
4.35Single5K2DZM2413855K2D-A2A-ZM241385
4.35Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
4.35Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
4.35Single6JZHZM2413856JZH-A2A-ZM241385-Na
4.35Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.35Single6PS7ZM2413856PS7-A2A-ZM241385-Na
4.35Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.35Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.35Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
4.35Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
4.35Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
4.35Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
4.35Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.35Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.35Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Single3REYPubChem 56973REY-A2A-PubChem 5697
4.17Single5IU4ZM2413855IU4-A2A-ZM241385-Na
4.17Single5IUBQ274563445IUB-A2A-Q27456344-Na
4.17Single5K2CZM2413855K2C-A2A-ZM241385-Na
4.17Single5NLXZM2413855NLX-A2A-ZM241385-Na
4.17Single5NM4ZM2413855NM4-A2A-ZM241385-Na
4.17Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
4.17Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.17Single7VV6C48/807VV6-MRGPRX2-C48/80
4.17Single8IYXYL-3658IYX-GPR34-YL-365
4.17Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
4.00Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.00Single5T04Neurotensin5T04-NTS1-Neurotensin
4.00Single6LPJZM2413856LPJ-A2A-ZM241385-Na
4.00Single6LPKZM2413856LPK-A2A-ZM241385-Na
4.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7RBTPubChem 1631837747RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single8GTIBMK-C2058GTI-CRF1-BMK-C205
3.85Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
3.85Single8GTGBMK-I1528GTG-CRF1-BMK-I152
3.85Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
3.85Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.70Single5V56TC1145V56-SMO-TC114
3.70Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
3.70Single7F1TMIP-1a7F1T-CCR5-MIP-1a
3.57Single6YVRNTS8-136YVR-NTS1-NTS8-13
3.57Single7SHEPI; PE7SHE-GPR158-PI; PE
3.57Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.57Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.57Consensusnts_onOrthosteric Ligandnts1_on
3.45Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.23Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
3.12Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.12Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.94Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
2.94Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.78Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
2.70Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
2.70Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
2.70Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
2.63Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
2.63Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
2.56Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.56Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.38Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.17Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2

PDB Summary
PDB 6K1Q
Class A
SubFamily Peptide
Type Endothelin
SubType ETB
Species Homo sapiens
Ligand IRL2500
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.7
Date 2019-07-17
D.O.I. 10.1038/s42003-019-0482-7
Net Summary
Imin 3.64
Number of Linked Nodes 287
Number of Links 316
Number of Hubs 36
Number of Links mediated by Hubs 144
Number of Communities 6
Number of Nodes involved in Communities 53
Number of Links involved in Communities 75
Path Summary
Number Of Nodes in MetaPath 107
Number Of Links MetaPath 106
Number of Shortest Paths 67609
Length Of Smallest Path 3
Average Path Length 14.3671
Length of Longest Path 33
Minimum Path Strength 1.455
Average Path Strength 7.19352
Maximum Path Strength 20.73
Minimum Path Correlation 0.7
Average Path Correlation 0.93913
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 55.0694
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 34.998
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeD2U
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeD2U
Name(2~{S})-2-[[(2~{R})-2-[(3,5-dimethylphenyl)carbonyl-methyl-amino]-3-(4-phenylphenyl)propanoyl]amino]-3-(1~{H}-indol-3-yl)propanoic acid
Synonyms
Identifier(2~{S})-2-[[(2~{R})-2-[(3,5-dimethylphenyl)carbonyl-methyl-amino]-3-(4-phenylphenyl)propanoyl]amino]-3-(1~{H}-indol-3-yl)propanoic acid
FormulaC36 H35 N3 O4
Molecular Weight573.681
SMILESCc1cc(cc(c1)C(=O)N(C)[C@H](Cc2ccc(cc2)c3ccccc3)C(=O)N[C@@H](Cc4c[nH]c5c4cccc5)C(=O)O)C
PubChem5311192
Formal Charge0
Total Atoms78
Total Chiral Atoms2
Total Bonds82
Total Aromatic Bonds28

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP24530
Sequence
>6K1Q_Chain_R
QGPIEIKET FKYINTVVS CLVFVLGII GNSTLLYII YKNKCMRNG 
PNILIASLA LGDLLHIVI DIPINVYKL LAEDWPFGA EMCKLVPFI 
QKASVGITV LSLCALSID RYRAVASWS VPKWTAVEI VLIWVVSVV 
LAVPEAIGF DIITMDYKG SYLRICLLH PVQKTAFMQ FYATAKDWW 
LFSFYFCLP LAITAFFYT LMTCEMLRK LNDHLKQRR EVAKTVFCL 
VLVFALCWL PLHLARILK LTLYNQNDP NRCELLSFL LVLDYIGIN 
MASLNSCAN PIALYLVSK RFKNAFKSA LCC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
etb_off5XPR-ETB-Bosentan
6K1Q-ETB-IRL2500
5X93-ETB-K-8794

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5GLHAPeptideEndothelinETBHomo sapiensEndothelin-1--2.82016-09-0710.1038/nature19319
5GLIAPeptideEndothelinETBHomo sapiens---2.52016-09-0710.1038/nature19319
5X93APeptideEndothelinETBHomo sapiensK-8794--2.22017-08-1610.1038/nsmb.3450
5XPRAPeptideEndothelinETBHomo sapiensBosentan--3.62017-08-1610.1038/nsmb.3450
6IGKAPeptideEndothelinETBHomo sapiensEndothelin-3--22018-11-2110.1038/s41467-018-07094-0
6IGLAPeptideEndothelinETBHomo sapiensIRL1620--2.72018-11-2110.1038/s41467-018-07094-0
6LRYAPeptideEndothelinETBHomo sapiensSarafotoxin-B--32020-02-1210.1016/j.bbrc.2019.12.091
8HBDAPeptideEndothelinETBHomo sapiensIRL1620-Gi1/&β;1/&γ;22.992023-03-2210.1038/s41467-023-36998-9
8HCXAPeptideEndothelinETBHomo sapiensEndothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;23.52023-03-2210.1038/s41467-023-36998-9
8IY5APeptideEndothelinETBHomo sapiensEndothelin-1-Gi1/&β;1/&γ;22.82023-08-1610.7554/eLife.85821
8IY6APeptideEndothelinETBHomo sapiensEndothelin-1--3.132023-08-1610.7554/eLife.85821




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6K1Q.zip



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