psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D246	R:R:I85	7	No	Yes	4	1	4
2	R:R:I85	R:R:Y251	6.04	Yes	No	4	4	5
3	R:R:M245	R:R:P88	6.71	No	Yes	0	1	7
4	R:R:P88	R:R:Y247	6.95	Yes	No	0	7	2
5	R:R:P89	R:R:R357	4.32	No	Yes	0	3	5
6	R:R:C90	R:R:R357	4.18	No	Yes	5	7	5
7	R:R:C358	R:R:C90	7.28	No	No	5	8	7
8	R:R:G92	R:R:Q91	3.29	No	No	0	4	4
9	R:R:G92	R:R:P93	4.06	No	No	0	4	4
10	R:R:L361	R:R:P93	4.93	No	No	0	3	4
11	R:R:E95	R:R:I94	4.1	No	No	0	5	4
12	R:R:I94	R:R:Y247	6.04	No	No	0	4	2
13	R:R:I96	R:R:S362	4.64	No	No	0	5	3
14	R:R:I96	R:R:L365	2.85	No	No	0	5	3
15	R:R:I96	R:R:V366	4.61	No	No	0	5	1
16	R:R:K97	R:R:Y369	3.58	No	No	0	3	3
17	R:R:E98	R:R:K101	9.45	No	No	6	3	6
18	R:R:E165	R:R:E98	3.81	No	No	6	4	3
19	R:R:F100	R:R:I103	10.05	No	No	0	4	5
20	R:R:F100	R:R:N104	7.25	No	No	0	4	5
21	R:R:F100	R:R:Y369	18.57	No	No	0	4	3
22	R:R:K101	R:R:Y102	3.58	No	No	0	6	3
23	R:R:E165	R:R:K101	12.15	No	No	6	4	6
24	R:R:N104	R:R:N373	10.9	No	No	0	5	5
25	R:R:L162	R:R:T105	2.95	No	No	0	4	6
26	R:R:L163	R:R:T105	2.95	No	No	0	4	6
27	R:R:N373	R:R:V107	11.82	No	No	0	5	5
28	R:R:L377	R:R:V107	2.98	No	No	0	6	5
29	R:R:S108	R:R:V159	3.23	No	No	0	7	7
30	R:R:S376	R:R:V111	4.85	No	No	0	7	8
31	R:R:C380	R:R:V111	5.12	No	No	0	8	8
32	R:R:F112	R:R:I151	5.02	No	No	7	7	6
33	R:R:F112	R:R:I155	5.02	No	Yes	7	7	7
34	R:R:C380	R:R:L114	4.76	No	No	0	8	5
35	R:R:I116	R:R:L148	2.85	No	No	0	7	7
36	R:R:I116	R:R:V152	3.07	No	No	0	7	5
37	R:R:G118	R:R:P383	4.06	No	No	0	8	9
38	R:R:A144	R:R:N119	4.69	No	Yes	0	9	9
39	R:R:D147	R:R:N119	5.39	No	Yes	0	9	9
40	R:R:N119	R:R:P383	4.89	Yes	No	0	9	9
41	R:R:L148	R:R:S120	4.5	No	No	0	7	4
42	R:R:F397	R:R:T121	5.19	Yes	No	0	7	6
43	R:R:L401	R:R:T121	2.95	No	No	0	6	6
44	R:R:I126	R:R:L122	4.28	No	Yes	0	7	9
45	R:R:I140	R:R:L122	2.85	No	Yes	0	8	9
46	R:R:A144	R:R:L122	4.73	No	Yes	0	9	9
47	R:R:F397	R:R:L122	3.65	Yes	Yes	0	7	9
48	R:R:I125	R:R:Y124	3.63	No	No	0	7	3
49	R:R:K128	R:R:Y124	11.94	No	No	0	4	3
50	R:R:A396	R:R:I125	4.87	No	No	0	4	7
51	R:R:A400	R:R:I125	3.25	No	No	0	6	7
52	R:R:I126	R:R:M132	2.92	No	Yes	0	7	7
53	R:R:A141	R:R:I126	4.87	No	No	0	7	7
54	R:R:R133	R:R:Y127	13.38	No	No	0	7	2
55	R:R:C131	R:R:N129	4.72	No	No	0	5	6
56	R:R:M132	R:R:N129	11.22	Yes	No	0	7	6
57	R:R:K130	R:R:R133	6.19	No	No	0	6	7
58	R:R:M132	R:R:N137	12.62	Yes	No	0	7	8
59	R:R:M132	R:R:R392	11.17	Yes	No	0	7	6
60	R:R:F393	R:R:M132	3.73	No	Yes	0	9	7
61	R:R:K210	R:R:N134	12.59	No	No	0	4	8
62	R:R:G135	R:R:P136	4.06	No	No	0	7	8
63	R:R:D198	R:R:P136	3.22	No	No	0	8	8
64	R:R:P136	R:R:R199	20.18	No	Yes	0	8	9
65	R:R:N137	R:R:R199	4.82	No	Yes	0	8	9
66	R:R:I138	R:R:V214	4.61	No	Yes	0	6	6
67	R:R:I138	R:R:I222	2.94	No	No	0	6	7
68	R:R:A194	R:R:L139	3.15	No	No	0	7	7
69	R:R:L139	R:R:T218	2.95	No	No	0	7	7
70	R:R:I222	R:R:L139	2.85	No	No	0	7	7
71	R:R:I140	R:R:L195	2.85	No	No	0	8	9
72	R:R:S142	R:R:S191	3.26	No	No	0	9	8
73	R:R:I222	R:R:S142	6.19	No	No	0	7	9
74	R:R:S142	R:R:W226	6.18	No	No	0	9	9
75	R:R:L143	R:R:T188	4.42	No	No	0	9	9
76	R:R:L143	R:R:N382	5.49	No	No	0	9	9
77	R:R:L145	R:R:L149	4.15	No	No	0	6	7
78	R:R:L145	R:R:W226	6.83	No	No	0	6	9
79	R:R:G146	R:R:I187	3.53	No	No	0	8	7
80	R:R:D147	R:R:T188	4.34	No	No	0	9	9
81	R:R:D147	R:R:S379	7.36	No	No	0	9	9
82	R:R:A154	R:R:H150	4.39	No	Yes	8	6	8
83	R:R:H150	R:R:Q181	7.42	Yes	No	8	8	6
84	R:R:H150	R:R:S184	9.76	Yes	No	0	8	8
85	R:R:H150	R:R:S379	4.18	Yes	No	0	8	9
86	R:R:I151	R:R:I155	2.94	No	Yes	7	6	7
87	R:R:I151	R:R:S379	4.64	No	No	0	6	9
88	R:R:I153	R:R:I180	10.3	No	No	0	5	5
89	R:R:A154	R:R:Q181	4.55	No	No	8	6	6
90	R:R:I155	R:R:P156	3.39	Yes	No	0	7	9
91	R:R:F169	R:R:I157	8.79	Yes	No	0	7	6
92	R:R:I157	R:R:M173	2.92	No	No	0	6	6
93	R:R:I157	R:R:V177	4.61	No	No	0	6	5
94	R:R:K161	R:R:N158	4.2	No	No	0	5	7
95	R:R:L163	R:R:V159	2.98	No	No	0	4	7
96	R:R:F169	R:R:Y160	5.16	Yes	No	0	7	4
97	R:R:K161	R:R:W167	5.8	No	Yes	0	5	9
98	R:R:D166	R:R:P168	3.22	No	No	0	5	2
99	R:R:D166	R:R:R253	14.29	No	No	0	5	5
100	R:R:F169	R:R:W167	12.03	Yes	Yes	0	7	9
101	R:R:C174	R:R:W167	3.92	No	Yes	3	9	9
102	R:R:I242	R:R:W167	4.7	Yes	Yes	3	5	9
103	R:R:C255	R:R:W167	13.06	No	Yes	3	9	9
104	R:R:F169	R:R:P168	10.11	Yes	No	0	7	2
105	R:R:C174	R:R:I242	4.91	No	Yes	3	9	5
106	R:R:C174	R:R:C255	7.28	No	No	3	9	9
107	R:R:D241	R:R:K175	5.53	No	No	0	4	7
108	R:R:I180	R:R:L176	4.28	No	No	0	5	5
109	R:R:P178	R:R:V177	3.53	No	No	0	5	5
110	R:R:Q181	R:R:V177	2.87	No	No	0	6	5
111	R:R:E236	R:R:P178	3.14	Yes	No	1	5	5
112	R:R:F240	R:R:P178	18.78	No	No	1	5	5
113	R:R:F179	R:R:I180	3.77	Yes	No	0	6	5
114	R:R:F179	R:R:V230	3.93	Yes	No	0	6	3
115	R:R:A233	R:R:F179	4.16	No	Yes	0	7	6
116	R:R:A237	R:R:F179	4.16	No	Yes	0	4	6
117	R:R:A233	R:R:K182	3.21	No	Yes	0	7	4
118	R:R:E236	R:R:K182	14.85	Yes	Yes	1	5	4
119	R:R:K182	R:R:Y269	4.78	Yes	Yes	1	4	3
120	R:R:K182	R:R:Y281	13.14	Yes	Yes	1	4	6
121	R:R:V185	R:R:Y281	6.31	No	Yes	0	7	6
122	R:R:V185	R:R:W336	4.9	No	Yes	0	7	8
123	R:R:G186	R:R:S229	3.71	No	No	0	6	8
124	R:R:G186	R:R:Y281	2.9	No	Yes	0	6	6
125	R:R:I187	R:R:W226	16.44	No	No	0	7	9
126	R:R:I187	R:R:S229	4.64	No	No	0	7	8
127	R:R:P285	R:R:V189	8.84	No	No	0	9	8
128	R:R:I225	R:R:L190	7.14	No	No	0	7	6
129	R:R:L190	R:R:V228	2.98	No	No	0	6	4
130	R:R:I225	R:R:S191	3.1	No	No	0	7	8
131	R:R:F332	R:R:L192	4.87	No	No	0	9	8
132	R:R:C193	R:R:I288	4.91	No	No	0	8	7
133	R:R:A194	R:R:E221	6.03	No	No	0	7	6
134	R:R:S196	R:R:T289	6.4	No	No	0	9	8
135	R:R:F292	R:R:I197	16.33	Yes	No	0	7	6
136	R:R:D198	R:R:R201	9.53	No	No	0	8	5
137	R:R:D198	R:R:E221	6.5	No	No	0	8	6
138	R:R:R199	R:R:V321	9.15	Yes	No	0	9	8
139	R:R:F292	R:R:Y200	4.13	Yes	No	0	7	8
140	R:R:L295	R:R:Y200	7.03	No	No	0	3	8
141	R:R:A202	R:R:R208	4.15	No	No	0	8	5
142	R:R:M296	R:R:V203	4.56	No	No	9	8	9
143	R:R:E299	R:R:V203	2.85	No	No	0	5	9
144	R:R:M300	R:R:V203	3.04	Yes	No	9	8	9
145	R:R:R208	R:R:S205	3.95	No	No	0	5	7
146	R:R:K303	R:R:W206	22.05	No	No	0	5	8
147	R:R:K210	R:R:R208	8.66	No	No	0	4	5
148	R:R:P215	R:R:V214	3.53	No	Yes	0	1	6
149	R:R:P215	R:R:T218	10.49	No	No	0	1	7
150	R:R:A219	R:R:K216	3.21	No	No	0	3	3
151	R:R:V220	R:R:W217	7.36	No	No	0	3	5
152	R:R:L224	R:R:V220	2.98	No	No	0	3	3
153	R:R:L232	R:R:V228	2.98	No	No	0	5	4
154	R:R:F280	R:R:L232	4.87	Yes	No	1	5	5
155	R:R:L232	R:R:Y281	3.52	No	Yes	1	5	6
156	R:R:P235	R:R:V234	3.53	No	No	0	8	4
157	R:R:I238	R:R:V234	3.07	No	No	0	5	4
158	R:R:M266	R:R:P235	3.35	Yes	No	1	4	8
159	R:R:P235	R:R:Y269	11.13	No	Yes	1	8	3
160	R:R:E236	R:R:F240	5.83	Yes	No	1	5	5
161	R:R:E236	R:R:Y269	11.22	Yes	Yes	1	5	3
162	R:R:I238	R:R:K262	4.36	No	Yes	1	5	1
163	R:R:I238	R:R:M266	4.37	No	Yes	1	5	4
164	R:R:G239	R:R:Q261	4.93	No	Yes	0	5	2
165	R:R:F240	R:R:L257	4.87	No	No	0	5	5
166	R:R:I243	R:R:L256	7.14	No	No	0	1	4
167	R:R:H258	R:R:I243	6.63	No	No	0	4	1
168	R:R:I254	R:R:M245	7.29	No	No	0	4	1
169	R:R:D246	R:R:Y251	13.79	No	No	4	1	5
170	R:R:K248	R:R:Y247	16.72	No	No	0	1	2
171	R:R:I254	R:R:L256	4.28	No	No	0	4	4
172	R:R:A270	R:R:L257	3.15	No	No	0	4	5
173	R:R:H258	R:R:P259	6.1	No	No	0	4	6
174	R:R:K262	R:R:Q261	6.78	Yes	Yes	1	1	2
175	R:R:M266	R:R:Q261	10.88	Yes	Yes	1	4	2
176	R:R:Q261	R:R:Q267	7.68	Yes	No	0	2	1
177	R:R:K262	R:R:T263	7.51	Yes	No	1	1	3
178	R:R:K262	R:R:M266	4.32	Yes	Yes	1	1	4
179	R:R:M266	R:R:T263	4.52	Yes	No	1	4	3
180	R:R:M266	R:R:Y269	4.79	Yes	Yes	1	4	3
181	R:R:D274	R:R:K273	9.68	No	No	0	5	7
182	R:R:D274	R:R:R343	15.48	No	Yes	0	5	6
183	R:R:F280	R:R:W276	11.02	Yes	No	1	5	4
184	R:R:W276	R:R:Y281	4.82	No	Yes	1	4	6
185	R:R:L277	R:R:Y281	3.52	No	Yes	0	6	6
186	R:R:H340	R:R:L277	3.86	Yes	No	0	8	6
187	R:R:L277	R:R:R343	3.64	No	Yes	0	6	6
188	R:R:F278	R:R:F282	3.22	Yes	Yes	2	6	8
189	R:R:C283	R:R:F278	8.38	No	Yes	0	5	6
190	R:R:F278	R:R:H340	14.71	Yes	Yes	2	6	8
191	R:R:F280	R:R:Y281	16.5	Yes	Yes	1	5	6
192	R:R:F280	R:R:L284	4.87	Yes	No	0	5	6
193	R:R:F282	R:R:L286	7.31	Yes	No	0	8	7
194	R:R:F282	R:R:L337	3.65	Yes	No	0	8	5
195	R:R:F282	R:R:H340	14.71	Yes	Yes	2	8	8
196	R:R:L284	R:R:P285	3.28	No	No	0	6	9
197	R:R:I288	R:R:L284	4.28	No	No	0	7	6
198	R:R:A333	R:R:L286	3.15	No	No	0	6	7
199	R:R:T289	R:R:V329	9.52	No	No	0	8	8
200	R:R:F291	R:R:F292	7.5	No	Yes	0	4	7
201	R:R:F291	R:R:L295	7.31	No	No	0	4	3
202	R:R:T297	R:R:Y293	8.74	No	No	0	5	9
203	R:R:F326	R:R:Y293	12.38	No	No	0	5	9
204	R:R:M296	R:R:M300	5.78	No	Yes	9	8	8
205	R:R:E299	R:R:K303	5.4	No	No	0	5	5
206	R:R:M300	R:R:R318	7.44	Yes	No	0	8	7
207	R:R:M300	R:R:V321	3.04	Yes	No	0	8	8
208	R:R:A322	R:R:M300	3.22	No	Yes	0	7	8
209	R:R:K303	R:R:R318	9.9	No	No	0	5	7
210	R:R:L311	R:R:R319	6.07	No	No	0	4	5
211	R:R:L315	R:R:N312	6.87	No	No	0	4	2
212	R:R:H314	R:R:R318	6.77	No	No	0	4	7
213	R:R:K316	R:R:R319	3.71	No	No	0	4	5
214	R:R:E320	R:R:S390	10.06	No	No	0	7	8
215	R:R:E320	R:R:R392	3.49	No	No	0	7	6
216	R:R:K323	R:R:V389	3.04	No	No	0	5	7
217	R:R:S390	R:R:T324	3.2	No	No	0	8	8
218	R:R:C327	R:R:V389	6.83	No	No	0	5	7
219	R:R:L328	R:R:N382	4.12	No	No	0	8	9
220	R:R:L328	R:R:L386	5.54	No	No	0	8	9
221	R:R:L330	R:R:L334	6.92	No	No	0	5	5
222	R:R:F332	R:R:W336	7.02	No	Yes	2	9	8
223	R:R:F332	R:R:N378	3.62	No	No	2	9	9
224	R:R:C335	R:R:N378	9.45	No	No	0	8	9
225	R:R:H340	R:R:W336	3.17	Yes	Yes	2	8	8
226	R:R:A375	R:R:W336	7.78	No	Yes	0	8	8
227	R:R:N378	R:R:W336	3.39	No	Yes	2	9	8
228	R:R:L337	R:R:P338	3.28	No	No	0	5	9
229	R:R:M374	R:R:P338	3.35	No	No	0	7	9
230	R:R:L339	R:R:R343	13.36	No	Yes	0	6	6
231	R:R:I344	R:R:L341	2.85	No	No	0	6	6
232	R:R:K346	R:R:L364	8.46	No	Yes	0	4	3
233	R:R:D368	R:R:K346	9.68	No	No	0	4	4
234	R:R:R357	R:R:Y350	9.26	Yes	No	0	5	2
235	R:R:L361	R:R:Y350	8.21	No	No	0	3	2
236	R:R:L364	R:R:Y350	3.52	Yes	No	0	3	2
237	R:R:N351	R:R:Q352	9.24	No	No	10	1	1
238	R:R:N351	R:R:N353	10.9	No	No	10	1	1
239	R:R:N353	R:R:Q352	9.24	No	No	10	1	1
240	R:R:D354	R:R:P355	6.44	No	No	0	1	1
241	R:R:D354	R:R:N356	4.04	No	No	0	1	3
242	R:R:E359	R:R:N356	7.89	No	No	0	4	3
243	R:R:C358	R:R:R357	6.96	No	Yes	5	8	5
244	R:R:F363	R:R:L367	6.09	No	No	0	3	5
245	R:R:L365	R:R:Y369	9.38	No	No	0	3	3
246	R:R:I370	R:R:V366	3.07	No	No	0	5	1
247	R:R:F397	R:R:P383	2.89	Yes	No	0	7	9
248	R:R:F393	R:R:L386	12.18	No	No	0	9	9
249	R:R:K394	R:R:Y387	14.33	No	Yes	11	8	7
250	R:R:F397	R:R:Y387	6.19	Yes	Yes	0	7	7
251	R:R:K398	R:R:Y387	7.17	No	Yes	11	4	7
252	R:R:F393	R:R:S390	6.61	No	No	0	9	8
253	R:R:K394	R:R:K398	5.75	No	No	11	8	4
254	R:R:L252	R:R:M245	2.83	No	No	0	3	1
255	R:R:D241	R:R:I242	2.8	No	Yes	0	4	5
256	R:R:D368	R:R:I372	2.8	No	No	0	4	6
257	R:R:L123	R:R:L145	2.77	No	No	0	7	6
258	R:R:H258	R:R:V260	2.77	No	No	0	4	3
259	R:R:A272	R:R:F268	2.77	No	No	0	4	1
260	R:R:L337	R:R:L341	2.77	No	No	0	5	6
261	R:R:L360	R:R:L364	2.77	No	Yes	0	2	3
262	R:R:L148	R:R:N119	2.75	No	Yes	0	7	9
263	R:R:E165	R:R:K97	2.7	No	No	0	4	3
264	R:R:F292	R:R:S196	2.64	Yes	No	0	7	9
265	R:R:R133	R:R:V214	2.62	No	Yes	0	7	6
266	R:R:R199	R:R:V325	2.62	Yes	No	0	9	8
267	R:R:H314	R:R:N312	2.55	No	No	0	4	2
268	R:R:V325	R:R:Y293	2.52	No	No	0	8	9
269	R:R:F292	R:R:I288	2.51	Yes	No	0	7	7
270	R:R:F326	R:R:L330	2.44	No	No	0	5	5
271	R:R:D368	R:R:R343	2.38	No	Yes	0	4	6
272	R:R:L388	R:R:Y387	2.34	No	Yes	0	6	7
273	R:R:L347	R:R:W275	2.28	No	No	0	5	5
274	R:R:G371	R:R:P338	2.03	No	No	0	7	9
275	R:R:F278	R:R:W275	2	Yes	No	0	6	5
276	R:R:C380	R:R:G115	1.96	No	No	0	8	8
277	R:R:P87	R:R:P88	1.95	No	Yes	0	7	7
278	R:R:P88	R:R:P89	1.95	Yes	No	0	7	3
279	R:R:G92	R:R:S362	1.86	No	No	0	4	3
280	R:R:A385	R:R:C327	1.81	No	No	0	7	5
281	R:R:A183	R:R:A233	1.79	No	No	0	6	7
282	R:R:P87	R:R:S86	1.78	No	No	0	7	5
283	R:R:G118	R:R:I117	1.76	No	No	0	8	5
284	R:R:G170	R:R:I242	1.76	No	Yes	0	8	5
285	R:R:G211	R:R:K210	1.74	No	No	0	3	4
286	R:R:C327	R:R:V331	1.71	No	No	0	5	6
287	R:R:C335	R:R:V331	1.71	No	No	0	8	6
288	R:R:G115	R:R:N119	1.7	No	Yes	0	8	9
289	R:R:G135	R:R:N134	1.7	No	No	0	7	8
290	R:R:A219	R:R:V214	1.7	No	Yes	0	3	6
291	R:R:A381	R:R:V331	1.7	No	No	0	6	6
292	R:R:I85	R:R:P87	1.69	Yes	No	0	4	7
293	R:R:C298	R:R:T294	1.69	No	No	0	4	4
294	R:R:A400	R:R:T121	1.68	No	No	0	6	6
295	R:R:D246	R:R:G249	1.68	No	No	0	1	3
296	R:R:A342	R:R:K346	1.61	No	No	0	5	4
297	R:R:V223	R:R:V227	1.6	No	No	0	3	4
298	R:R:A342	R:R:L367	1.58	No	No	0	5	5
299	R:R:I155	R:R:S108	1.55	Yes	No	0	7	7
300	R:R:I117	R:R:V113	1.54	No	No	0	5	5
301	R:R:A171	R:R:D241	1.54	No	No	0	3	4
302	R:R:I85	R:R:T244	1.52	Yes	No	0	4	1
303	R:R:K216	R:R:V220	1.52	No	No	0	3	3
304	R:R:A171	R:R:E172	1.51	No	No	0	3	1
305	R:R:L252	R:R:S250	1.5	No	No	0	3	1
306	R:R:L110	R:R:V106	1.49	No	No	0	4	6
307	R:R:L347	R:R:T348	1.47	No	No	0	5	4
308	R:R:L349	R:R:T348	1.47	No	No	0	3	4
309	R:R:K323	R:R:K391	1.44	No	No	0	5	5
310	R:R:I384	R:R:L114	1.43	No	No	0	7	5
311	R:R:I384	R:R:L388	1.43	No	No	0	7	6
312	R:R:L311	R:R:L315	1.38	No	No	0	4	4
313	R:R:L345	R:R:L349	1.38	No	No	0	5	3
314	R:R:L345	R:R:L364	1.38	No	Yes	0	5	3
315	R:R:L345	R:R:L367	1.38	No	No	0	5	5
316	R:R:F265	R:R:M266	1.24	No	Yes	0	3	4
317	R:R:D354	R:R:R357	1.19	No	Yes	0	1	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I85	4.0625	4	4	4
2	R:R:P88	4.39	4	0	7
3	R:R:N119	3.884	5	0	9
4	R:R:L122	3.8775	4	0	9
5	R:R:M132	8.332	5	0	7
6	R:R:H150	6.4375	4	8	8
7	R:R:I155	3.225	4	7	7
8	R:R:W167	7.902	5	3	9
9	R:R:F169	9.0225	4	0	7
10	R:R:F179	4.005	4	0	6
11	R:R:K182	8.995	4	1	4
12	R:R:R199	9.1925	4	0	9
13	R:R:V214	3.115	4	0	6
14	R:R:E236	8.76	4	1	5
15	R:R:I242	3.5425	4	3	5
16	R:R:Q261	7.5675	4	1	2
17	R:R:K262	5.7425	4	1	1
18	R:R:M266	4.78143	7	1	4
19	R:R:Y269	7.98	4	1	3
20	R:R:F278	7.0775	4	2	6
21	R:R:F280	9.315	4	1	5
22	R:R:Y281	7.24429	7	1	6
23	R:R:F282	7.2225	4	2	8
24	R:R:F292	6.622	5	0	7
25	R:R:M300	4.504	5	9	8
26	R:R:W336	5.252	5	2	8
27	R:R:H340	9.1125	4	2	8
28	R:R:R343	8.715	4	0	6
29	R:R:R357	5.182	5	5	5
30	R:R:L364	4.0325	4	0	3
31	R:R:Y387	7.5075	4	11	7
32	R:R:F397	4.48	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P87	R:R:P88	12.6017	1.95	No	Yes	0	7	7
2	R:R:M245	R:R:P88	16.0878	6.71	No	Yes	0	1	7
3	R:R:P88	R:R:P89	35.9199	1.95	Yes	No	0	7	3
4	R:R:P89	R:R:R357	37.3854	4.32	No	Yes	0	3	5
5	R:R:R357	R:R:Y350	47.9148	9.26	Yes	No	0	5	2
6	R:R:L361	R:R:Y350	35.8231	8.21	No	No	0	3	2
7	R:R:L361	R:R:P93	34.2414	4.93	No	No	0	3	4
8	R:R:G92	R:R:P93	32.6469	4.06	No	No	0	4	4
9	R:R:G92	R:R:S362	29.419	1.86	No	No	0	4	3
10	R:R:I96	R:R:S362	27.7857	4.64	No	No	0	5	3
11	R:R:I96	R:R:L365	22.8083	2.85	No	No	0	5	3
12	R:R:L365	R:R:Y369	21.1233	9.38	No	No	0	3	3
13	R:R:F100	R:R:Y369	10.8393	18.57	No	No	0	4	3
14	R:R:L364	R:R:Y350	77.0755	3.52	Yes	No	0	3	2
15	R:R:K346	R:R:L364	79.0768	8.46	No	Yes	0	4	3
16	R:R:D368	R:R:K346	84.0736	9.68	No	No	0	4	4
17	R:R:D368	R:R:R343	86.1524	2.38	No	Yes	0	4	6
18	R:R:L277	R:R:R343	90.1356	3.64	No	Yes	0	6	6
19	R:R:L277	R:R:Y281	100	3.52	No	Yes	0	6	6
20	R:R:K182	R:R:Y281	96.4622	13.14	Yes	Yes	1	4	6
21	R:R:E236	R:R:K182	78.9864	14.85	Yes	Yes	1	5	4
22	R:R:E236	R:R:P178	83.0019	3.14	Yes	No	1	5	5
23	R:R:P178	R:R:V177	84.8677	3.53	No	No	0	5	5
24	R:R:Q181	R:R:V177	76.0362	2.87	No	No	0	6	5
25	R:R:H150	R:R:Q181	74.2414	7.42	Yes	No	8	8	6
26	R:R:H150	R:R:S379	73.6669	4.18	Yes	No	0	8	9
27	R:R:I151	R:R:S379	15.9716	4.64	No	No	0	6	9
28	R:R:I151	R:R:I155	12.4661	2.94	No	Yes	7	6	7
29	R:R:D147	R:R:S379	67.3402	7.36	No	No	0	9	9
30	R:R:D147	R:R:N119	58.8509	5.39	No	Yes	0	9	9
31	R:R:G115	R:R:N119	10.2905	1.7	No	Yes	0	8	9
32	R:R:N119	R:R:P383	19.7999	4.89	Yes	No	0	9	9
33	R:R:A144	R:R:N119	31.3622	4.69	No	Yes	0	9	9
34	R:R:F397	R:R:P383	17.011	2.89	Yes	No	0	7	9
35	R:R:F397	R:R:T121	12.8728	5.19	Yes	No	0	7	6
36	R:R:A144	R:R:L122	30.6779	4.73	No	Yes	0	9	9
37	R:R:I126	R:R:L122	37.4048	4.28	No	Yes	0	7	9
38	R:R:I126	R:R:M132	35.765	2.92	No	Yes	0	7	7
39	R:R:G186	R:R:Y281	57.9212	2.9	No	Yes	0	6	6
40	R:R:G186	R:R:S229	56.9722	3.71	No	No	0	6	8
41	R:R:I187	R:R:S229	56.062	4.64	No	No	0	7	8
42	R:R:I187	R:R:W226	54.4868	16.44	No	No	0	7	9
43	R:R:S142	R:R:W226	51.8012	6.18	No	No	0	9	9
44	R:R:I222	R:R:S142	58.2569	6.19	No	No	0	7	9
45	R:R:I138	R:R:I222	19.6966	2.94	No	No	0	6	7
46	R:R:I138	R:R:V214	17.9148	4.61	No	Yes	0	6	6
47	R:R:I222	R:R:L139	48.8831	2.85	No	No	0	7	7
48	R:R:A194	R:R:L139	51.8141	3.15	No	No	0	7	7
49	R:R:A194	R:R:E221	51.0717	6.03	No	No	0	7	6
50	R:R:D198	R:R:E221	50.2647	6.5	No	No	0	8	6
51	R:R:D198	R:R:P136	49.2253	3.22	No	No	0	8	8
52	R:R:P136	R:R:R199	44.8935	20.18	No	Yes	0	8	9
53	R:R:N137	R:R:R199	31.0136	4.82	No	Yes	0	8	9
54	R:R:D147	R:R:T188	10.368	4.34	No	No	0	9	9
55	R:R:G135	R:R:P136	13.5442	4.06	No	No	0	7	8
56	R:R:G135	R:R:N134	11.6269	1.7	No	No	0	7	8
57	R:R:L232	R:R:V228	10.5229	2.98	No	No	0	5	4
58	R:R:A233	R:R:K182	14.2995	3.21	No	Yes	0	7	4
59	R:R:A233	R:R:F179	10.8005	4.16	No	Yes	0	7	6
60	R:R:I157	R:R:V177	31.02	4.61	No	No	0	6	5
61	R:R:F169	R:R:I157	27.7792	8.79	Yes	No	0	7	6
62	R:R:F169	R:R:W167	19.4513	12.03	Yes	Yes	0	7	9
63	R:R:I242	R:R:W167	10.7618	4.7	Yes	Yes	3	5	9
64	R:R:K182	R:R:Y269	13.0536	4.78	Yes	Yes	1	4	3
65	R:R:V185	R:R:Y281	17.4952	6.31	No	Yes	0	7	6
66	R:R:H340	R:R:L277	29.8773	3.86	Yes	No	0	8	6
67	R:R:F280	R:R:Y281	25.5584	16.5	Yes	Yes	1	5	6
68	R:R:F280	R:R:L284	29.0962	4.87	Yes	No	0	5	6
69	R:R:I288	R:R:L284	23.073	4.28	No	No	0	7	6
70	R:R:F292	R:R:I288	18.9929	2.51	Yes	No	0	7	7
71	R:R:R199	R:R:V321	28.9671	9.15	Yes	No	0	9	8
72	R:R:M300	R:R:V321	27.224	3.04	Yes	No	0	8	8
73	R:R:M300	R:R:R318	17.7534	7.44	Yes	No	0	8	7
74	R:R:A219	R:R:V214	12.195	1.7	No	Yes	0	3	6
75	R:R:M266	R:R:Y269	15.3325	4.79	Yes	Yes	1	4	3
76	R:R:I254	R:R:M245	10.8393	7.29	No	No	0	4	1
77	R:R:F282	R:R:H340	15.5584	14.71	Yes	Yes	2	8	8
78	R:R:F282	R:R:L337	10.8393	3.65	Yes	No	0	8	5
79	R:R:R199	R:R:V325	11.9432	2.62	Yes	No	0	9	8
80	R:R:V325	R:R:Y293	10.0968	2.52	No	No	0	8	9
81	R:R:H314	R:R:R318	12.0788	6.77	No	No	0	4	7
82	R:R:H314	R:R:N312	10.0968	2.55	No	No	0	4	2
83	R:R:N378	R:R:W336	15.9135	3.39	No	Yes	2	9	8
84	R:R:C335	R:R:N378	14.2995	9.45	No	No	0	8	9
85	R:R:C335	R:R:V331	12.5565	1.71	No	No	0	8	6
86	R:R:M132	R:R:N137	30.4519	12.62	Yes	No	0	7	8
87	R:R:V185	R:R:W336	16.0426	4.9	No	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 5GLI

PDB Summary
PDB	5GLI
Class	A
SubFamily	Peptide
Type	Endothelin
SubType	ETB
Species	Homo sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.5
Date	2016-09-07
D.O.I.	10.1038/nature19319

Net Summary
I_min	2.85
Number of Linked Nodes	290
Number of Links	317
Number of Hubs	32
Number of Links mediated by Hubs	124
Number of Communities	11
Number of Nodes involved in Communities	49
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	41624
Length Of Smallest Path	3
Average Path Length	15.397
Length of Longest Path	40
Minimum Path Strength	1.38
Average Path Strength	5.85805
Maximum Path Strength	15.975
Minimum Path Correlation	0.7
Average Path Correlation	0.928847
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	46.8717
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.005
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P24530
Sequence	>5GLI_Chain_R I S P P P C Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L Y I I Y K N K C M R N G P N I L I A S L A L G D L L H I V I A I P I N V Y K L L A E D W P F G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S W S R I K G I G V P K W T A V E I V L I W V V S V V L A V P E A I G F D I I T M D Y K G S Y L R I C L L H P V Q K T A F M Q F Y A T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K L N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L A R I L K L T L Y N Q N D P N R C E L L S F L L V L D Y I G I N M A S L N S C A N P I A L Y L V S K R F K N A F K S A L C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5GLH	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	2.8	2016-09-07	10.1038/nature19319
	5X93	A	Peptide	Endothelin	ET_B	Homo sapiens	K-8794	-	-	2.2	2017-08-16	10.1038/nsmb.3450
	5XPR	A	Peptide	Endothelin	ET_B	Homo sapiens	Bosentan	-	-	3.6	2017-08-16	10.1038/nsmb.3450
	6IGK	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-3	-	-	2	2018-11-21	10.1038/s41467-018-07094-0
	6IGL	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-	-	2.7	2018-11-21	10.1038/s41467-018-07094-0
	6K1Q	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL2500	-	-	2.7	2019-07-17	10.1038/s42003-019-0482-7
	6LRY	A	Peptide	Endothelin	ET_B	Homo sapiens	Sarafotoxin-B	-	-	3	2020-02-12	10.1016/j.bbrc.2019.12.091
	8HBD	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-	Gi1/&β;1/&γ;2	2.99	2023-03-22	10.1038/s41467-023-36998-9
	8HCX	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	3.5	2023-03-22	10.1038/s41467-023-36998-9
	8IY5	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/&β;1/&γ;2	2.8	2023-08-16	10.7554/eLife.85821
	8IY6	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	3.13	2023-08-16	10.7554/eLife.85821

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5GLI.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.