psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C90	R:R:Q91	7.63	Yes	No	2	7	4
2	R:R:C90	R:R:R357	4.18	Yes	Yes	2	7	5
3	R:R:C358	R:R:C90	7.28	No	Yes	2	8	7
4	R:R:C358	R:R:Q91	6.1	No	No	2	8	4
5	R:R:G92	R:R:P93	4.06	No	No	0	4	4
6	R:R:I94	R:R:P93	3.39	No	No	0	4	4
7	R:R:E95	R:R:I94	4.1	No	No	0	5	4
8	R:R:I96	R:R:L365	12.85	No	No	0	5	3
9	R:R:I96	R:R:V366	4.61	No	No	0	5	1
10	R:R:K97	R:R:Y369	8.36	No	No	0	3	3
11	R:R:E98	R:R:K101	10.8	No	No	0	3	6
12	R:R:E98	R:R:Y102	3.37	No	No	0	3	3
13	R:R:F100	R:R:I103	5.02	Yes	No	0	4	5
14	R:R:F100	R:R:V366	5.24	Yes	No	0	4	1
15	R:R:F100	R:R:Y369	19.6	Yes	No	0	4	3
16	R:R:E165	R:R:K101	2.7	No	No	0	4	6
17	R:R:L162	R:R:N104	8.24	No	No	0	4	5
18	R:R:N104	R:R:N373	8.17	No	No	0	5	5
19	R:R:T105	R:R:V159	6.35	No	No	0	6	7
20	R:R:N373	R:R:V107	8.87	No	No	0	5	5
21	R:R:I155	R:R:S108	3.1	Yes	No	0	7	7
22	R:R:S108	R:R:V159	3.23	No	No	0	7	7
23	R:R:L110	R:R:L114	2.77	No	No	0	4	5
24	R:R:I155	R:R:V111	3.07	Yes	No	0	7	8
25	R:R:S376	R:R:V111	4.85	No	No	0	7	8
26	R:R:C380	R:R:V111	8.54	No	No	0	8	8
27	R:R:F112	R:R:P156	5.78	No	No	0	7	9
28	R:R:G115	R:R:N119	3.39	No	Yes	0	8	9
29	R:R:G118	R:R:P383	4.06	No	No	0	8	9
30	R:R:A144	R:R:N119	4.69	No	Yes	0	9	9
31	R:R:I151	R:R:N119	2.83	No	Yes	0	6	9
32	R:R:N119	R:R:P383	13.03	Yes	No	0	9	9
33	R:R:L148	R:R:S120	4.5	No	No	0	7	4
34	R:R:F397	R:R:T121	3.89	No	No	0	7	6
35	R:R:L401	R:R:T121	13.27	No	No	0	6	6
36	R:R:A144	R:R:L122	4.73	No	No	0	9	9
37	R:R:L122	R:R:L386	2.77	No	Yes	5	9	9
38	R:R:F393	R:R:L122	3.65	Yes	No	5	9	9
39	R:R:L123	R:R:L145	2.77	No	No	0	7	6
40	R:R:Y124	R:R:Y127	7.94	Yes	No	0	3	2
41	R:R:K128	R:R:Y124	3.58	No	Yes	0	4	3
42	R:R:A400	R:R:Y124	2.67	No	Yes	0	6	3
43	R:R:W404	R:R:Y124	7.72	No	Yes	0	1	3
44	R:R:I125	R:R:M132	2.92	No	Yes	0	7	7
45	R:R:A396	R:R:I125	4.87	No	No	0	4	7
46	R:R:F397	R:R:I125	8.79	No	No	0	7	7
47	R:R:R133	R:R:Y127	3.09	No	No	0	7	2
48	R:R:M132	R:R:N129	5.61	Yes	No	0	7	6
49	R:R:C131	R:R:R392	5.57	No	No	0	5	6
50	R:R:M132	R:R:R392	12.41	Yes	No	0	7	6
51	R:R:F393	R:R:M132	7.46	Yes	Yes	0	9	7
52	R:R:G135	R:R:N134	5.09	Yes	No	3	7	8
53	R:R:N134	R:R:P136	8.15	No	No	3	8	8
54	R:R:N134	R:R:N137	10.9	No	No	0	8	8
55	R:R:G135	R:R:P136	4.06	Yes	No	3	7	8
56	R:R:P136	R:R:R199	2.88	No	No	0	8	9
57	R:R:L139	R:R:S191	3	Yes	No	0	7	8
58	R:R:A194	R:R:L139	3.15	No	Yes	0	7	7
59	R:R:L139	R:R:L195	8.3	Yes	No	0	7	9
60	R:R:D198	R:R:L139	2.71	No	Yes	0	8	7
61	R:R:I222	R:R:L139	2.85	No	Yes	0	7	7
62	R:R:I140	R:R:L328	2.85	No	No	5	8	8
63	R:R:I140	R:R:L386	2.85	No	Yes	5	8	9
64	R:R:I222	R:R:S142	3.1	No	No	0	7	9
65	R:R:S142	R:R:W226	6.18	No	Yes	0	9	9
66	R:R:L143	R:R:T188	4.42	No	No	0	9	9
67	R:R:L143	R:R:S191	6.01	No	No	0	9	8
68	R:R:L143	R:R:N382	2.75	No	No	0	9	9
69	R:R:L145	R:R:W226	5.69	No	Yes	0	6	9
70	R:R:G146	R:R:W226	2.81	No	Yes	0	8	9
71	R:R:D147	R:R:T188	4.34	No	No	0	9	9
72	R:R:D147	R:R:S379	7.36	No	No	0	9	9
73	R:R:L148	R:R:V152	4.47	No	No	0	7	5
74	R:R:I153	R:R:L149	2.85	No	No	0	5	7
75	R:R:A154	R:R:H150	4.39	No	Yes	0	6	8
76	R:R:H150	R:R:I155	6.63	Yes	Yes	0	8	7
77	R:R:H150	R:R:Q181	7.42	Yes	No	0	8	6
78	R:R:H150	R:R:S184	8.37	Yes	No	0	8	8
79	R:R:H150	R:R:S379	6.97	Yes	No	0	8	9
80	R:R:I151	R:R:I155	4.42	No	Yes	0	6	7
81	R:R:I151	R:R:S379	3.1	No	No	0	6	9
82	R:R:I155	R:R:P156	3.39	Yes	No	0	7	9
83	R:R:I157	R:R:V177	6.14	No	No	0	6	5
84	R:R:N158	R:R:Q181	3.96	No	No	0	7	6
85	R:R:K161	R:R:W167	11.6	No	Yes	0	5	9
86	R:R:D166	R:R:L252	5.43	No	No	0	5	3
87	R:R:D166	R:R:R253	5.96	No	No	0	5	5
88	R:R:F169	R:R:W167	4.01	Yes	Yes	0	7	9
89	R:R:C174	R:R:W167	3.92	No	Yes	1	9	9
90	R:R:V177	R:R:W167	3.68	No	Yes	0	5	9
91	R:R:C255	R:R:W167	15.67	No	Yes	1	9	9
92	R:R:F169	R:R:P168	2.89	Yes	No	0	7	2
93	R:R:F169	R:R:M173	4.98	Yes	No	0	7	6
94	R:R:L176	R:R:M173	2.83	No	No	0	5	6
95	R:R:C174	R:R:F240	2.79	No	No	1	9	5
96	R:R:C174	R:R:C255	5.46	No	No	1	9	9
97	R:R:P178	R:R:V177	5.3	No	No	0	5	5
98	R:R:E236	R:R:P178	9.43	Yes	No	1	5	5
99	R:R:F240	R:R:P178	17.34	No	No	1	5	5
100	R:R:F179	R:R:I180	5.02	Yes	No	0	6	5
101	R:R:F179	R:R:V230	2.62	Yes	No	0	6	3
102	R:R:A233	R:R:F179	2.77	No	Yes	0	7	6
103	R:R:A237	R:R:F179	4.16	No	Yes	0	4	6
104	R:R:E236	R:R:K182	9.45	Yes	No	0	5	4
105	R:R:K182	R:R:L277	7.05	No	No	0	4	6
106	R:R:V185	R:R:Y281	5.05	No	No	0	7	6
107	R:R:V185	R:R:W336	3.68	No	Yes	0	7	8
108	R:R:G186	R:R:S229	3.71	No	No	0	6	8
109	R:R:I187	R:R:W226	11.74	No	Yes	0	7	9
110	R:R:I187	R:R:S229	6.19	No	No	0	7	8
111	R:R:F332	R:R:T188	2.59	Yes	No	0	9	9
112	R:R:P285	R:R:V189	12.37	No	No	0	9	8
113	R:R:F332	R:R:V189	3.93	Yes	No	0	9	8
114	R:R:I225	R:R:L190	4.28	No	No	0	7	6
115	R:R:L190	R:R:V228	2.98	No	No	0	6	4
116	R:R:L190	R:R:S229	6.01	No	No	0	6	8
117	R:R:I225	R:R:S191	3.1	No	No	0	7	8
118	R:R:L192	R:R:V329	5.96	No	No	0	8	8
119	R:R:F332	R:R:L192	4.87	Yes	No	0	9	8
120	R:R:C193	R:R:I288	6.55	No	No	0	8	7
121	R:R:L195	R:R:V325	4.47	No	No	0	9	8
122	R:R:I197	R:R:S196	3.1	No	No	6	6	9
123	R:R:S196	R:R:T289	4.8	No	No	0	9	8
124	R:R:F292	R:R:S196	2.64	Yes	No	6	7	9
125	R:R:F292	R:R:I197	8.79	Yes	No	6	7	6
126	R:R:R199	R:R:V321	9.15	No	No	0	9	8
127	R:R:A322	R:R:R199	2.77	No	No	0	7	9
128	R:R:A204	R:R:Y200	6.67	No	No	0	7	8
129	R:R:F292	R:R:Y200	6.19	Yes	No	0	7	8
130	R:R:L295	R:R:Y200	7.03	No	No	0	3	8
131	R:R:M296	R:R:V203	3.04	No	No	0	8	9
132	R:R:P215	R:R:V214	3.53	No	No	3	1	6
133	R:R:T218	R:R:V214	3.17	No	No	3	7	6
134	R:R:P215	R:R:T218	10.49	No	No	3	1	7
135	R:R:L224	R:R:V228	2.98	No	No	0	3	4
136	R:R:F280	R:R:L232	4.87	Yes	No	0	5	5
137	R:R:P235	R:R:V234	3.53	No	No	0	8	4
138	R:R:I238	R:R:V234	3.07	No	No	0	5	4
139	R:R:P235	R:R:Y269	12.52	No	Yes	0	8	3
140	R:R:E236	R:R:F240	9.33	Yes	No	1	5	5
141	R:R:E236	R:R:Y269	8.98	Yes	Yes	1	5	3
142	R:R:E236	R:R:K273	9.45	Yes	No	1	5	7
143	R:R:G239	R:R:I238	3.53	No	No	0	5	5
144	R:R:I238	R:R:M266	7.29	No	Yes	0	5	4
145	R:R:G239	R:R:Q261	4.93	No	Yes	0	5	2
146	R:R:D241	R:R:I242	2.8	No	No	0	4	5
147	R:R:D241	R:R:I243	5.6	No	No	0	4	1
148	R:R:C255	R:R:I242	3.27	No	No	0	9	5
149	R:R:I243	R:R:T244	6.08	No	No	0	1	1
150	R:R:H258	R:R:I243	9.28	Yes	No	0	4	1
151	R:R:L252	R:R:M245	7.07	No	No	0	3	1
152	R:R:I254	R:R:M245	2.92	No	No	0	4	1
153	R:R:D246	R:R:Y251	5.75	No	No	0	1	5
154	R:R:K248	R:R:Y247	19.11	No	No	0	1	2
155	R:R:L252	R:R:S250	3	No	No	0	3	1
156	R:R:L257	R:R:Q261	2.66	No	Yes	0	5	2
157	R:R:A270	R:R:L257	3.15	No	No	0	4	5
158	R:R:K273	R:R:L257	2.82	No	No	0	7	5
159	R:R:H258	R:R:P259	7.63	Yes	No	0	4	6
160	R:R:H258	R:R:V260	4.15	Yes	No	0	4	3
161	R:R:H258	R:R:Q261	4.95	Yes	Yes	0	4	2
162	R:R:M266	R:R:Q261	6.8	Yes	Yes	0	4	2
163	R:R:Q261	R:R:Q267	3.84	Yes	No	0	2	1
164	R:R:M266	R:R:T263	3.01	Yes	No	0	4	3
165	R:R:F265	R:R:M266	3.73	No	Yes	0	3	4
166	R:R:K273	R:R:Y269	4.78	No	Yes	1	7	3
167	R:R:W276	R:R:Y269	2.89	No	Yes	0	4	3
168	R:R:D274	R:R:R343	14.29	No	No	0	5	6
169	R:R:L347	R:R:W275	6.83	No	No	0	5	5
170	R:R:F280	R:R:W276	14.03	Yes	No	0	5	4
171	R:R:L277	R:R:Y281	4.69	No	No	0	6	6
172	R:R:H340	R:R:L277	6.43	Yes	No	0	8	6
173	R:R:F278	R:R:F282	8.57	Yes	Yes	4	6	8
174	R:R:C283	R:R:F278	4.19	No	Yes	0	5	6
175	R:R:F278	R:R:H340	7.92	Yes	Yes	4	6	8
176	R:R:F278	R:R:I344	5.02	Yes	No	0	6	6
177	R:R:F280	R:R:Y281	9.28	Yes	No	0	5	6
178	R:R:F280	R:R:L284	7.31	Yes	No	0	5	6
179	R:R:F282	R:R:L286	4.87	Yes	No	0	8	7
180	R:R:F282	R:R:L337	3.65	Yes	No	0	8	5
181	R:R:F282	R:R:H340	13.58	Yes	Yes	4	8	8
182	R:R:L284	R:R:P285	3.28	No	No	0	6	9
183	R:R:A333	R:R:L286	3.15	No	No	0	6	7
184	R:R:T289	R:R:V329	7.93	No	No	0	8	8
185	R:R:F291	R:R:F292	6.43	No	Yes	0	4	7
186	R:R:T297	R:R:Y293	8.74	No	No	0	5	9
187	R:R:F326	R:R:Y293	13.41	No	No	0	5	9
188	R:R:M296	R:R:M300	4.33	No	No	0	8	8
189	R:R:M300	R:R:R318	9.93	No	No	0	8	7
190	R:R:D313	R:R:H314	8.82	No	No	0	3	4
191	R:R:H314	R:R:K316	7.86	No	No	0	4	4
192	R:R:L315	R:R:Q317	3.99	No	No	0	4	5
193	R:R:K323	R:R:V389	4.55	No	No	0	5	7
194	R:R:L386	R:R:T324	2.95	Yes	No	0	9	8
195	R:R:S390	R:R:T324	3.2	No	No	0	8	8
196	R:R:C327	R:R:V389	3.42	No	No	0	5	7
197	R:R:L328	R:R:N382	5.49	No	No	0	8	9
198	R:R:L328	R:R:L386	5.54	No	Yes	5	8	9
199	R:R:L330	R:R:L334	2.77	No	No	0	5	5
200	R:R:F332	R:R:W336	7.02	Yes	Yes	4	9	8
201	R:R:F332	R:R:N378	3.62	Yes	No	4	9	9
202	R:R:C335	R:R:N378	4.72	No	No	0	8	9
203	R:R:L339	R:R:W336	3.42	No	Yes	0	6	8
204	R:R:H340	R:R:W336	8.46	Yes	Yes	4	8	8
205	R:R:A375	R:R:W336	9.08	No	Yes	0	8	8
206	R:R:N378	R:R:W336	3.39	No	Yes	4	9	8
207	R:R:L337	R:R:P338	3.28	No	No	0	5	9
208	R:R:M374	R:R:P338	6.71	No	No	0	7	9
209	R:R:L339	R:R:R343	7.29	No	No	0	6	6
210	R:R:G371	R:R:L339	3.42	No	No	0	7	6
211	R:R:A342	R:R:D368	4.63	No	No	0	5	4
212	R:R:D368	R:R:R343	8.34	No	No	0	4	6
213	R:R:L345	R:R:L364	5.54	No	Yes	0	5	3
214	R:R:K346	R:R:L364	8.46	No	Yes	0	4	3
215	R:R:L349	R:R:T348	8.84	No	No	0	3	4
216	R:R:Q352	R:R:Y350	6.76	No	Yes	2	1	2
217	R:R:R357	R:R:Y350	7.2	Yes	Yes	2	5	2
218	R:R:L361	R:R:Y350	9.38	No	Yes	0	3	2
219	R:R:N351	R:R:N353	5.45	No	No	0	1	1
220	R:R:D354	R:R:N351	6.73	No	No	0	1	1
221	R:R:Q352	R:R:R357	3.5	No	Yes	2	1	5
222	R:R:D354	R:R:P355	4.83	No	No	0	1	1
223	R:R:E359	R:R:N356	15.77	No	No	0	4	3
224	R:R:C358	R:R:R357	4.18	No	Yes	2	8	5
225	R:R:L360	R:R:L364	4.15	No	Yes	0	2	3
226	R:R:L361	R:R:L365	2.77	No	No	0	3	3
227	R:R:L365	R:R:Y369	5.86	No	No	0	3	3
228	R:R:D368	R:R:I372	2.8	No	No	0	4	6
229	R:R:I370	R:R:M374	2.92	No	No	0	5	7
230	R:R:F393	R:R:L386	8.53	Yes	Yes	5	9	9
231	R:R:K394	R:R:Y387	3.58	No	No	7	8	7
232	R:R:F397	R:R:Y387	5.16	No	No	0	7	7
233	R:R:K398	R:R:Y387	11.94	No	No	7	4	7
234	R:R:F393	R:R:S390	6.61	Yes	No	0	9	8
235	R:R:K391	R:R:K394	4.31	No	No	0	5	8
236	R:R:K394	R:R:K398	5.75	No	No	7	8	4
237	R:R:F100	R:R:I370	2.51	Yes	No	0	4	5
238	R:R:F393	R:R:I126	2.51	Yes	No	0	9	7
239	R:R:I242	R:R:R253	2.51	No	No	0	5	5
240	R:R:F292	R:R:I288	2.51	Yes	No	0	7	7
241	R:R:V220	R:R:W217	2.45	No	No	0	3	5
242	R:R:F363	R:R:L364	2.44	No	Yes	0	3	3
243	R:R:F363	R:R:L367	2.44	No	No	0	3	5
244	R:R:F100	R:R:N373	2.42	Yes	No	0	4	5
245	R:R:F393	R:R:N137	2.42	Yes	No	0	9	8
246	R:R:D198	R:R:R201	2.38	No	No	0	8	5
247	R:R:L360	R:R:Y350	2.34	No	Yes	0	2	2
248	R:R:G135	R:R:P215	2.03	Yes	No	3	7	1
249	R:R:C90	R:R:G92	1.96	Yes	No	0	7	4
250	R:R:A385	R:R:C327	1.81	No	No	0	7	5
251	R:R:A183	R:R:A233	1.79	No	No	0	6	7
252	R:R:G118	R:R:I117	1.76	No	No	0	8	5
253	R:R:G135	R:R:I138	1.76	Yes	No	0	7	6
254	R:R:G115	R:R:L114	1.71	No	No	0	8	5
255	R:R:C327	R:R:V331	1.71	No	No	0	5	6
256	R:R:C335	R:R:V331	1.71	No	No	0	8	6
257	R:R:A381	R:R:V331	1.7	No	No	0	6	6
258	R:R:A400	R:R:T121	1.68	No	No	0	6	6
259	R:R:D246	R:R:G249	1.68	No	No	0	1	3
260	R:R:E172	R:R:G170	1.64	No	No	0	1	8
261	R:R:A141	R:R:I126	1.62	No	No	0	7	7
262	R:R:A141	R:R:I138	1.62	No	No	0	7	6
263	R:R:A322	R:R:M296	1.61	No	No	0	7	8
264	R:R:V223	R:R:V227	1.6	No	No	0	3	4
265	R:R:V227	R:R:V231	1.6	No	No	0	4	4
266	R:R:T105	R:R:V106	1.59	No	No	0	6	6
267	R:R:C380	R:R:L377	1.59	No	No	0	8	6
268	R:R:I96	R:R:S362	1.55	No	No	0	5	3
269	R:R:I116	R:R:S120	1.55	No	No	0	7	4
270	R:R:I153	R:R:V152	1.54	No	No	0	5	5
271	R:R:I103	R:R:T99	1.52	No	No	0	5	5
272	R:R:I344	R:R:T348	1.52	No	No	0	6	4
273	R:R:F169	R:R:G170	1.51	Yes	No	0	7	8
274	R:R:A194	R:R:E221	1.51	No	No	0	7	6
275	R:R:K262	R:R:T263	1.5	No	No	0	1	3
276	R:R:L163	R:R:V159	1.49	No	No	0	4	7
277	R:R:I116	R:R:I117	1.47	No	No	0	7	5
278	R:R:L347	R:R:T348	1.47	No	No	0	5	4
279	R:R:I384	R:R:L114	1.43	No	No	0	7	5
280	R:R:I180	R:R:L149	1.43	No	No	0	5	7
281	R:R:I180	R:R:L176	1.43	No	No	0	5	5
282	R:R:E221	R:R:V220	1.43	No	No	0	6	3
283	R:R:I384	R:R:L388	1.43	No	No	0	7	6
284	R:R:Q267	R:R:T271	1.42	No	No	0	1	4
285	R:R:K304	R:R:L301	1.41	No	No	0	3	5
286	R:R:A272	R:R:F268	1.39	No	No	0	4	1
287	R:R:E320	R:R:K391	1.35	No	No	0	7	5
288	R:R:E299	R:R:L295	1.33	No	No	0	5	3
289	R:R:N351	R:R:Q352	1.32	No	No	0	1	1
290	R:R:A272	R:R:W275	1.3	No	No	0	4	5
291	R:R:M245	R:R:Y247	1.2	No	No	0	1	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C90	5.2625	4	2	7
2	R:R:F100	6.958	5	0	4
3	R:R:N119	5.985	4	0	9
4	R:R:Y124	5.4775	4	0	3
5	R:R:M132	7.1	4	0	7
6	R:R:G135	3.235	4	3	7
7	R:R:L139	4.002	5	0	7
8	R:R:H150	6.756	5	0	8
9	R:R:I155	4.122	5	0	7
10	R:R:W167	7.776	5	1	9
11	R:R:F169	3.3475	4	0	7
12	R:R:F179	3.6425	4	0	6
13	R:R:W226	6.605	4	0	9
14	R:R:E236	9.328	5	1	5
15	R:R:H258	6.5025	4	0	4
16	R:R:Q261	4.636	5	0	2
17	R:R:M266	5.2075	4	0	4
18	R:R:Y269	7.2925	4	1	3
19	R:R:F278	6.425	4	4	6
20	R:R:F280	8.8725	4	0	5
21	R:R:F282	7.6675	4	4	8
22	R:R:F292	5.312	5	6	7
23	R:R:F332	4.406	5	4	9
24	R:R:W336	5.84167	6	4	8
25	R:R:H340	9.0975	4	4	8
26	R:R:Y350	6.42	4	2	2
27	R:R:R357	4.765	4	2	5
28	R:R:L364	5.1475	4	0	3
29	R:R:L386	4.528	5	5	9
30	R:R:F393	5.19667	6	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:R357	R:R:Y350	13.3766	7.2	Yes	Yes	2	5	2
2	R:R:L361	R:R:Y350	30.3409	9.38	No	Yes	0	3	2
3	R:R:L361	R:R:L365	31.6785	2.77	No	No	0	3	3
4	R:R:L365	R:R:Y369	32.63	5.86	No	No	0	3	3
5	R:R:F100	R:R:Y369	35.1822	19.6	Yes	No	0	4	3
6	R:R:F100	R:R:I370	47.7305	2.51	Yes	No	0	4	5
7	R:R:I370	R:R:M374	48.9114	2.92	No	No	0	5	7
8	R:R:M374	R:R:P338	50.07	6.71	No	No	0	7	9
9	R:R:L337	R:R:P338	51.2173	3.28	No	No	0	5	9
10	R:R:F282	R:R:L337	52.3535	3.65	Yes	No	0	8	5
11	R:R:F282	R:R:H340	53.5792	13.58	Yes	Yes	4	8	8
12	R:R:H340	R:R:W336	89.7577	8.46	Yes	Yes	4	8	8
13	R:R:F332	R:R:W336	90.9778	7.02	Yes	Yes	4	9	8
14	R:R:F332	R:R:T188	100	2.59	Yes	No	0	9	9
15	R:R:D147	R:R:T188	44.2324	4.34	No	No	0	9	9
16	R:R:D147	R:R:S379	43.4824	7.36	No	No	0	9	9
17	R:R:H150	R:R:S379	19.203	6.97	Yes	No	0	8	9
18	R:R:H150	R:R:I155	14.3617	6.63	Yes	Yes	0	8	7
19	R:R:I155	R:R:S108	12.3916	3.1	Yes	No	0	7	7
20	R:R:I151	R:R:S379	27.5312	3.1	No	No	0	6	9
21	R:R:I151	R:R:I155	18.6601	4.42	No	Yes	0	6	7
22	R:R:I151	R:R:N119	21.1283	2.83	No	Yes	0	6	9
23	R:R:N119	R:R:P383	12.6938	13.03	Yes	No	0	9	9
24	R:R:G118	R:R:P383	11.5184	4.06	No	No	0	8	9
25	R:R:A144	R:R:N119	12.9345	4.69	No	Yes	0	9	9
26	R:R:G118	R:R:I117	10.4494	1.76	No	No	0	8	5
27	R:R:L143	R:R:T188	69.0771	4.42	No	No	0	9	9
28	R:R:L143	R:R:N382	46.2753	2.75	No	No	0	9	9
29	R:R:L328	R:R:N382	45.3853	5.49	No	No	0	8	9
30	R:R:L328	R:R:L386	43.6671	5.54	No	Yes	5	8	9
31	R:R:F393	R:R:L386	39.878	8.53	Yes	Yes	5	9	9
32	R:R:F393	R:R:M132	28.3484	7.46	Yes	Yes	0	9	7
33	R:R:I125	R:R:M132	23.0201	2.92	No	Yes	0	7	7
34	R:R:F397	R:R:I125	20.2888	8.79	No	No	0	7	7
35	R:R:F397	R:R:T121	11.9046	3.89	No	No	0	7	6
36	R:R:L143	R:R:S191	33.9732	6.01	No	No	0	9	8
37	R:R:L139	R:R:S191	22.522	3	Yes	No	0	7	8
38	R:R:F393	R:R:N137	19.8522	2.42	Yes	No	0	9	8
39	R:R:N134	R:R:N137	18.5426	10.9	No	No	0	8	8
40	R:R:N134	R:R:P136	11.3561	8.15	No	No	3	8	8
41	R:R:P136	R:R:R199	10.1976	2.88	No	No	0	8	9
42	R:R:H340	R:R:L277	68.9931	6.43	Yes	No	0	8	6
43	R:R:K182	R:R:L277	67.6331	7.05	No	No	0	4	6
44	R:R:E236	R:R:K182	66.9111	9.45	Yes	No	0	5	4
45	R:R:E236	R:R:P178	18.9399	9.43	Yes	No	1	5	5
46	R:R:P178	R:R:V177	17.8821	5.3	No	No	0	5	5
47	R:R:V177	R:R:W167	15.7889	3.68	No	Yes	0	5	9
48	R:R:F169	R:R:W167	29.0256	4.01	Yes	Yes	0	7	9
49	R:R:F169	R:R:M173	19.3541	4.98	Yes	No	0	7	6
50	R:R:L176	R:R:M173	17.9493	2.83	No	No	0	5	6
51	R:R:I180	R:R:L176	16.7068	1.43	No	No	0	5	5
52	R:R:E236	R:R:F240	30.6935	9.33	Yes	No	1	5	5
53	R:R:C174	R:R:F240	29.7084	2.79	No	No	1	9	5
54	R:R:C174	R:R:W167	15.5146	3.92	No	Yes	1	9	9
55	R:R:C174	R:R:C255	13.1639	5.46	No	No	1	9	9
56	R:R:C255	R:R:I242	15.1117	3.27	No	No	0	9	5
57	R:R:I242	R:R:R253	11.6808	2.51	No	No	0	5	5
58	R:R:D166	R:R:R253	10.2591	5.96	No	No	0	5	5
59	R:R:F179	R:R:I180	11.0763	5.02	Yes	No	0	6	5
60	R:R:I225	R:R:S191	10.7461	3.1	No	No	0	7	8
61	R:R:F332	R:R:L192	20.0761	4.87	Yes	No	0	9	8
62	R:R:L192	R:R:V329	18.5985	5.96	No	No	0	8	8
63	R:R:F292	R:R:S196	12.5315	2.64	Yes	No	6	7	9
64	R:R:S196	R:R:T289	15.6098	4.8	No	No	0	9	8
65	R:R:T289	R:R:V329	17.1098	7.93	No	No	0	8	8
66	R:R:E236	R:R:K273	20.7589	9.45	Yes	No	1	5	7
67	R:R:K273	R:R:L257	20.3056	2.82	No	No	0	7	5
68	R:R:L257	R:R:Q261	17.8094	2.66	No	Yes	0	5	2
69	R:R:F280	R:R:W276	10.3431	14.03	Yes	No	0	5	4
70	R:R:L339	R:R:W336	10.7629	3.42	No	Yes	0	6	8
71	R:R:F278	R:R:I344	10.6845	5.02	Yes	No	0	6	6
72	R:R:C335	R:R:N378	10.802	4.72	No	No	0	8	9
73	R:R:F393	R:R:L122	10.8468	3.65	Yes	No	5	9	9
74	R:R:A144	R:R:L122	12.1621	4.73	No	No	0	9	9
75	R:R:F278	R:R:H340	11.5296	7.92	Yes	Yes	4	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9KDG

PDB Summary
PDB	9KDG
Class	A
SubFamily	Peptide
Type	Endothelin
SubType	ETB
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.33
Date	2025-05-07
D.O.I.	doi.org/10.1038/s41467-025-57960-x

Net Summary
I_min	2.59
Number of Linked Nodes	273
Number of Links	291
Number of Hubs	30
Number of Links mediated by Hubs	120
Number of Communities	7
Number of Nodes involved in Communities	37
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	37869
Length Of Smallest Path	3
Average Path Length	14.4456
Length of Longest Path	33
Minimum Path Strength	1.345
Average Path Strength	5.45874
Maximum Path Strength	13.98
Minimum Path Correlation	0.7
Average Path Correlation	0.931578
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	53.1154
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.8784
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Rotamase-like
SCOP2	Family Identifier	• Rotamase-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P24530
Sequence	>9KDG_Chain_R C Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L I I Y K N K C M R N G P N I L I A S L A L G D L L H I V I I P I N V Y K L L A E D W P F G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A V P K W T A V E I V L I W V V S V V L A V P E A I G F D I I T M D Y K G S Y L R I C L L H P V Q K T A F M Q F Y T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L R I L K L T L Y N Q N D P N R C E L L S F L L V L D Y I G I N M A S L N S C N P I A L Y L V S K R F K N F K S L C C W Y A A A A A A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6LRY	A	Peptide	Endothelin	ET_B	Homo sapiens	Sarafotoxin-B	-	-	3	2020-02-12	doi.org/10.1016/j.bbrc.2019.12.091
	5GLH	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	2.8	2016-09-07	doi.org/10.1038/nature19319
	5GLI	A	Peptide	Endothelin	ET_B	Homo sapiens	-	-	-	2.5	2016-09-07	doi.org/10.1038/nature19319
	5X93	A	Peptide	Endothelin	ET_B	Homo sapiens	K-8794	-	-	2.2	2017-08-16	doi.org/10.1038/nsmb.3450
	5XPR	A	Peptide	Endothelin	ET_B	Homo sapiens	Bosentan	-	-	3.6	2017-08-16	doi.org/10.1038/nsmb.3450
	6IGK	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-3	-	-	2	2018-11-21	doi.org/10.1038/s41467-018-07094-0
	6IGL	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-	-	2.7	2018-11-21	doi.org/10.1038/s41467-018-07094-0
	8HBD	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-	Gi1/β1/γ2	2.99	2023-03-22	doi.org/10.1038/s41467-023-36998-9
	8HBD (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-		2.99	2023-03-22	doi.org/10.1038/s41467-023-36998-9
	8HCX	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.5	2023-03-22	doi.org/10.1038/s41467-023-36998-9
	8HCX (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		3.5	2023-03-22	doi.org/10.1038/s41467-023-36998-9
	6K1Q	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL2500	-	-	2.7	2019-07-17	doi.org/10.1038/s42003-019-0482-7
	8IY5	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/β1/γ2	2.8	2023-08-16	doi.org/10.7554/eLife.85821
	8IY5 (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		2.8	2023-08-16	doi.org/10.7554/eLife.85821
	8IY6	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	3.13	2023-08-16	doi.org/10.7554/eLife.85821
	8XVE	A	Peptide	Endothelin	ET_B	Homo sapiens	BQ3020	-	chim(Gs-CtGq)/β1/γ2	3	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVE (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	BQ3020	-		3	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVH	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	chim(Gs-CtGq)/β1/γ2	3.26	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVH (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		3.26	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	9KDF	A	Peptide	Endothelin	ET_B	Homo sapiens	RES-701-3	-	-	3.3	2025-05-07	doi.org/10.1038/s41467-025-57960-x
	8XWP	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/β1/γ2	3.21	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWP (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		3.21	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWQ	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/β1/γ2	4.6	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWQ (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		4.6	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8ZRT	A	Peptide	Endothelin	ET_B	Homo sapiens	ET-1	-	-	3.62	2024-10-02	doi.org/10.1038/s42003-024-06905-z

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9KDG.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.