psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C90	R:R:Q91	7.63	Yes	No	2	7	4
2	R:R:C90	R:R:R357	4.18	Yes	Yes	2	7	5
3	R:R:C358	R:R:C90	7.28	No	Yes	2	8	7
4	R:R:C358	R:R:Q91	6.1	No	No	2	8	4
5	R:R:G92	R:R:P93	4.06	No	No	0	4	4
6	R:R:I94	R:R:P93	3.39	No	No	0	4	4
7	R:R:E95	R:R:I94	4.1	No	No	0	5	4
8	R:R:I96	R:R:L365	12.85	No	No	0	5	3
9	R:R:I96	R:R:V366	4.61	No	No	0	5	1
10	R:R:K97	R:R:Y369	8.36	No	No	0	3	3
11	R:R:E98	R:R:K101	10.8	No	No	0	3	6
12	R:R:E98	R:R:Y102	3.37	No	No	0	3	3
13	R:R:F100	R:R:I103	5.02	Yes	No	0	4	5
14	R:R:F100	R:R:V366	5.24	Yes	No	0	4	1
15	R:R:F100	R:R:Y369	19.6	Yes	No	0	4	3
16	R:R:E165	R:R:K101	2.7	No	No	0	4	6
17	R:R:L162	R:R:N104	8.24	No	No	0	4	5
18	R:R:N104	R:R:N373	8.17	No	No	0	5	5
19	R:R:T105	R:R:V159	6.35	No	No	0	6	7
20	R:R:N373	R:R:V107	8.87	No	No	0	5	5
21	R:R:I155	R:R:S108	3.1	Yes	No	0	7	7
22	R:R:S108	R:R:V159	3.23	No	No	0	7	7
23	R:R:L110	R:R:L114	2.77	No	No	0	4	5
24	R:R:I155	R:R:V111	3.07	Yes	No	0	7	8
25	R:R:S376	R:R:V111	4.85	No	No	0	7	8
26	R:R:C380	R:R:V111	8.54	No	No	0	8	8
27	R:R:F112	R:R:P156	5.78	No	No	0	7	9
28	R:R:G115	R:R:N119	3.39	No	Yes	0	8	9
29	R:R:G118	R:R:P383	4.06	No	No	0	8	9
30	R:R:A144	R:R:N119	4.69	No	Yes	0	9	9
31	R:R:I151	R:R:N119	2.83	No	Yes	0	6	9
32	R:R:N119	R:R:P383	13.03	Yes	No	0	9	9
33	R:R:L148	R:R:S120	4.5	No	No	0	7	4
34	R:R:F397	R:R:T121	3.89	No	No	0	7	6
35	R:R:L401	R:R:T121	13.27	No	No	0	6	6
36	R:R:A144	R:R:L122	4.73	No	No	0	9	9
37	R:R:L122	R:R:L386	2.77	No	Yes	5	9	9
38	R:R:F393	R:R:L122	3.65	Yes	No	5	9	9
39	R:R:L123	R:R:L145	2.77	No	No	0	7	6
40	R:R:Y124	R:R:Y127	7.94	Yes	No	0	3	2
41	R:R:K128	R:R:Y124	3.58	No	Yes	0	4	3
42	R:R:A400	R:R:Y124	2.67	No	Yes	0	6	3
43	R:R:W404	R:R:Y124	7.72	No	Yes	0	1	3
44	R:R:I125	R:R:M132	2.92	No	Yes	0	7	7
45	R:R:A396	R:R:I125	4.87	No	No	0	4	7
46	R:R:F397	R:R:I125	8.79	No	No	0	7	7
47	R:R:R133	R:R:Y127	3.09	No	No	0	7	2
48	R:R:M132	R:R:N129	5.61	Yes	No	0	7	6
49	R:R:C131	R:R:R392	5.57	No	No	0	5	6
50	R:R:M132	R:R:R392	12.41	Yes	No	0	7	6
51	R:R:F393	R:R:M132	7.46	Yes	Yes	0	9	7
52	R:R:G135	R:R:N134	5.09	Yes	No	3	7	8
53	R:R:N134	R:R:P136	8.15	No	No	3	8	8
54	R:R:N134	R:R:N137	10.9	No	No	0	8	8
55	R:R:G135	R:R:P136	4.06	Yes	No	3	7	8
56	R:R:P136	R:R:R199	2.88	No	No	0	8	9
57	R:R:L139	R:R:S191	3	Yes	No	0	7	8
58	R:R:A194	R:R:L139	3.15	No	Yes	0	7	7
59	R:R:L139	R:R:L195	8.3	Yes	No	0	7	9
60	R:R:D198	R:R:L139	2.71	No	Yes	0	8	7
61	R:R:I222	R:R:L139	2.85	No	Yes	0	7	7
62	R:R:I140	R:R:L328	2.85	No	No	5	8	8
63	R:R:I140	R:R:L386	2.85	No	Yes	5	8	9
64	R:R:I222	R:R:S142	3.1	No	No	0	7	9
65	R:R:S142	R:R:W226	6.18	No	Yes	0	9	9
66	R:R:L143	R:R:T188	4.42	No	No	0	9	9
67	R:R:L143	R:R:S191	6.01	No	No	0	9	8
68	R:R:L143	R:R:N382	2.75	No	No	0	9	9
69	R:R:L145	R:R:W226	5.69	No	Yes	0	6	9
70	R:R:G146	R:R:W226	2.81	No	Yes	0	8	9
71	R:R:D147	R:R:T188	4.34	No	No	0	9	9
72	R:R:D147	R:R:S379	7.36	No	No	0	9	9
73	R:R:L148	R:R:V152	4.47	No	No	0	7	5
74	R:R:I153	R:R:L149	2.85	No	No	0	5	7
75	R:R:A154	R:R:H150	4.39	No	Yes	0	6	8
76	R:R:H150	R:R:I155	6.63	Yes	Yes	0	8	7
77	R:R:H150	R:R:Q181	7.42	Yes	No	0	8	6
78	R:R:H150	R:R:S184	8.37	Yes	No	0	8	8
79	R:R:H150	R:R:S379	6.97	Yes	No	0	8	9
80	R:R:I151	R:R:I155	4.42	No	Yes	0	6	7
81	R:R:I151	R:R:S379	3.1	No	No	0	6	9
82	R:R:I155	R:R:P156	3.39	Yes	No	0	7	9
83	R:R:I157	R:R:V177	6.14	No	No	0	6	5
84	R:R:N158	R:R:Q181	3.96	No	No	0	7	6
85	R:R:K161	R:R:W167	11.6	No	Yes	0	5	9
86	R:R:D166	R:R:L252	5.43	No	No	0	5	3
87	R:R:D166	R:R:R253	5.96	No	No	0	5	5
88	R:R:F169	R:R:W167	4.01	Yes	Yes	0	7	9
89	R:R:C174	R:R:W167	3.92	No	Yes	1	9	9
90	R:R:V177	R:R:W167	3.68	No	Yes	0	5	9
91	R:R:C255	R:R:W167	15.67	No	Yes	1	9	9
92	R:R:F169	R:R:P168	2.89	Yes	No	0	7	2
93	R:R:F169	R:R:M173	4.98	Yes	No	0	7	6
94	R:R:L176	R:R:M173	2.83	No	No	0	5	6
95	R:R:C174	R:R:F240	2.79	No	No	1	9	5
96	R:R:C174	R:R:C255	5.46	No	No	1	9	9
97	R:R:P178	R:R:V177	5.3	No	No	0	5	5
98	R:R:E236	R:R:P178	9.43	Yes	No	1	5	5
99	R:R:F240	R:R:P178	17.34	No	No	1	5	5
100	R:R:F179	R:R:I180	5.02	Yes	No	0	6	5
101	R:R:F179	R:R:V230	2.62	Yes	No	0	6	3
102	R:R:A233	R:R:F179	2.77	No	Yes	0	7	6
103	R:R:A237	R:R:F179	4.16	No	Yes	0	4	6
104	R:R:E236	R:R:K182	9.45	Yes	No	0	5	4
105	R:R:K182	R:R:L277	7.05	No	No	0	4	6
106	R:R:V185	R:R:Y281	5.05	No	No	0	7	6
107	R:R:V185	R:R:W336	3.68	No	Yes	0	7	8
108	R:R:G186	R:R:S229	3.71	No	No	0	6	8
109	R:R:I187	R:R:W226	11.74	No	Yes	0	7	9
110	R:R:I187	R:R:S229	6.19	No	No	0	7	8
111	R:R:F332	R:R:T188	2.59	Yes	No	0	9	9
112	R:R:P285	R:R:V189	12.37	No	No	0	9	8
113	R:R:F332	R:R:V189	3.93	Yes	No	0	9	8
114	R:R:I225	R:R:L190	4.28	No	No	0	7	6
115	R:R:L190	R:R:V228	2.98	No	No	0	6	4
116	R:R:L190	R:R:S229	6.01	No	No	0	6	8
117	R:R:I225	R:R:S191	3.1	No	No	0	7	8
118	R:R:L192	R:R:V329	5.96	No	No	0	8	8
119	R:R:F332	R:R:L192	4.87	Yes	No	0	9	8
120	R:R:C193	R:R:I288	6.55	No	No	0	8	7
121	R:R:L195	R:R:V325	4.47	No	No	0	9	8
122	R:R:I197	R:R:S196	3.1	No	No	6	6	9
123	R:R:S196	R:R:T289	4.8	No	No	0	9	8
124	R:R:F292	R:R:S196	2.64	Yes	No	6	7	9
125	R:R:F292	R:R:I197	8.79	Yes	No	6	7	6
126	R:R:R199	R:R:V321	9.15	No	No	0	9	8
127	R:R:A322	R:R:R199	2.77	No	No	0	7	9
128	R:R:A204	R:R:Y200	6.67	No	No	0	7	8
129	R:R:F292	R:R:Y200	6.19	Yes	No	0	7	8
130	R:R:L295	R:R:Y200	7.03	No	No	0	3	8
131	R:R:M296	R:R:V203	3.04	No	No	0	8	9
132	R:R:P215	R:R:V214	3.53	No	No	3	1	6
133	R:R:T218	R:R:V214	3.17	No	No	3	7	6
134	R:R:P215	R:R:T218	10.49	No	No	3	1	7
135	R:R:L224	R:R:V228	2.98	No	No	0	3	4
136	R:R:F280	R:R:L232	4.87	Yes	No	0	5	5
137	R:R:P235	R:R:V234	3.53	No	No	0	8	4
138	R:R:I238	R:R:V234	3.07	No	No	0	5	4
139	R:R:P235	R:R:Y269	12.52	No	Yes	0	8	3
140	R:R:E236	R:R:F240	9.33	Yes	No	1	5	5
141	R:R:E236	R:R:Y269	8.98	Yes	Yes	1	5	3
142	R:R:E236	R:R:K273	9.45	Yes	No	1	5	7
143	R:R:G239	R:R:I238	3.53	No	No	0	5	5
144	R:R:I238	R:R:M266	7.29	No	Yes	0	5	4
145	R:R:G239	R:R:Q261	4.93	No	Yes	0	5	2
146	R:R:D241	R:R:I242	2.8	No	No	0	4	5
147	R:R:D241	R:R:I243	5.6	No	No	0	4	1
148	R:R:C255	R:R:I242	3.27	No	No	0	9	5
149	R:R:I243	R:R:T244	6.08	No	No	0	1	1
150	R:R:H258	R:R:I243	9.28	Yes	No	0	4	1
151	R:R:L252	R:R:M245	7.07	No	No	0	3	1
152	R:R:I254	R:R:M245	2.92	No	No	0	4	1
153	R:R:D246	R:R:Y251	5.75	No	No	0	1	5
154	R:R:K248	R:R:Y247	19.11	No	No	0	1	2
155	R:R:L252	R:R:S250	3	No	No	0	3	1
156	R:R:L257	R:R:Q261	2.66	No	Yes	0	5	2
157	R:R:A270	R:R:L257	3.15	No	No	0	4	5
158	R:R:K273	R:R:L257	2.82	No	No	0	7	5
159	R:R:H258	R:R:P259	7.63	Yes	No	0	4	6
160	R:R:H258	R:R:V260	4.15	Yes	No	0	4	3
161	R:R:H258	R:R:Q261	4.95	Yes	Yes	0	4	2
162	R:R:M266	R:R:Q261	6.8	Yes	Yes	0	4	2
163	R:R:Q261	R:R:Q267	3.84	Yes	No	0	2	1
164	R:R:M266	R:R:T263	3.01	Yes	No	0	4	3
165	R:R:F265	R:R:M266	3.73	No	Yes	0	3	4
166	R:R:K273	R:R:Y269	4.78	No	Yes	1	7	3
167	R:R:W276	R:R:Y269	2.89	No	Yes	0	4	3
168	R:R:D274	R:R:R343	14.29	No	No	0	5	6
169	R:R:L347	R:R:W275	6.83	No	No	0	5	5
170	R:R:F280	R:R:W276	14.03	Yes	No	0	5	4
171	R:R:L277	R:R:Y281	4.69	No	No	0	6	6
172	R:R:H340	R:R:L277	6.43	Yes	No	0	8	6
173	R:R:F278	R:R:F282	8.57	Yes	Yes	4	6	8
174	R:R:C283	R:R:F278	4.19	No	Yes	0	5	6
175	R:R:F278	R:R:H340	7.92	Yes	Yes	4	6	8
176	R:R:F278	R:R:I344	5.02	Yes	No	0	6	6
177	R:R:F280	R:R:Y281	9.28	Yes	No	0	5	6
178	R:R:F280	R:R:L284	7.31	Yes	No	0	5	6
179	R:R:F282	R:R:L286	4.87	Yes	No	0	8	7
180	R:R:F282	R:R:L337	3.65	Yes	No	0	8	5
181	R:R:F282	R:R:H340	13.58	Yes	Yes	4	8	8
182	R:R:L284	R:R:P285	3.28	No	No	0	6	9
183	R:R:A333	R:R:L286	3.15	No	No	0	6	7
184	R:R:T289	R:R:V329	7.93	No	No	0	8	8
185	R:R:F291	R:R:F292	6.43	No	Yes	0	4	7
186	R:R:T297	R:R:Y293	8.74	No	No	0	5	9
187	R:R:F326	R:R:Y293	13.41	No	No	0	5	9
188	R:R:M296	R:R:M300	4.33	No	No	0	8	8
189	R:R:M300	R:R:R318	9.93	No	No	0	8	7
190	R:R:D313	R:R:H314	8.82	No	No	0	3	4
191	R:R:H314	R:R:K316	7.86	No	No	0	4	4
192	R:R:L315	R:R:Q317	3.99	No	No	0	4	5
193	R:R:K323	R:R:V389	4.55	No	No	0	5	7
194	R:R:L386	R:R:T324	2.95	Yes	No	0	9	8
195	R:R:S390	R:R:T324	3.2	No	No	0	8	8
196	R:R:C327	R:R:V389	3.42	No	No	0	5	7
197	R:R:L328	R:R:N382	5.49	No	No	0	8	9
198	R:R:L328	R:R:L386	5.54	No	Yes	5	8	9
199	R:R:L330	R:R:L334	2.77	No	No	0	5	5
200	R:R:F332	R:R:W336	7.02	Yes	Yes	4	9	8
201	R:R:F332	R:R:N378	3.62	Yes	No	4	9	9
202	R:R:C335	R:R:N378	4.72	No	No	0	8	9
203	R:R:L339	R:R:W336	3.42	No	Yes	0	6	8
204	R:R:H340	R:R:W336	8.46	Yes	Yes	4	8	8
205	R:R:A375	R:R:W336	9.08	No	Yes	0	8	8
206	R:R:N378	R:R:W336	3.39	No	Yes	4	9	8
207	R:R:L337	R:R:P338	3.28	No	No	0	5	9
208	R:R:M374	R:R:P338	6.71	No	No	0	7	9
209	R:R:L339	R:R:R343	7.29	No	No	0	6	6
210	R:R:G371	R:R:L339	3.42	No	No	0	7	6
211	R:R:A342	R:R:D368	4.63	No	No	0	5	4
212	R:R:D368	R:R:R343	8.34	No	No	0	4	6
213	R:R:L345	R:R:L364	5.54	No	Yes	0	5	3
214	R:R:K346	R:R:L364	8.46	No	Yes	0	4	3
215	R:R:L349	R:R:T348	8.84	No	No	0	3	4
216	R:R:Q352	R:R:Y350	6.76	No	Yes	2	1	2
217	R:R:R357	R:R:Y350	7.2	Yes	Yes	2	5	2
218	R:R:L361	R:R:Y350	9.38	No	Yes	0	3	2
219	R:R:N351	R:R:N353	5.45	No	No	0	1	1
220	R:R:D354	R:R:N351	6.73	No	No	0	1	1
221	R:R:Q352	R:R:R357	3.5	No	Yes	2	1	5
222	R:R:D354	R:R:P355	4.83	No	No	0	1	1
223	R:R:E359	R:R:N356	15.77	No	No	0	4	3
224	R:R:C358	R:R:R357	4.18	No	Yes	2	8	5
225	R:R:L360	R:R:L364	4.15	No	Yes	0	2	3
226	R:R:L361	R:R:L365	2.77	No	No	0	3	3
227	R:R:L365	R:R:Y369	5.86	No	No	0	3	3
228	R:R:D368	R:R:I372	2.8	No	No	0	4	6
229	R:R:I370	R:R:M374	2.92	No	No	0	5	7
230	R:R:F393	R:R:L386	8.53	Yes	Yes	5	9	9
231	R:R:K394	R:R:Y387	3.58	No	No	7	8	7
232	R:R:F397	R:R:Y387	5.16	No	No	0	7	7
233	R:R:K398	R:R:Y387	11.94	No	No	7	4	7
234	R:R:F393	R:R:S390	6.61	Yes	No	0	9	8
235	R:R:K391	R:R:K394	4.31	No	No	0	5	8
236	R:R:K394	R:R:K398	5.75	No	No	7	8	4
237	R:R:F100	R:R:I370	2.51	Yes	No	0	4	5
238	R:R:F393	R:R:I126	2.51	Yes	No	0	9	7
239	R:R:I242	R:R:R253	2.51	No	No	0	5	5
240	R:R:F292	R:R:I288	2.51	Yes	No	0	7	7
241	R:R:V220	R:R:W217	2.45	No	No	0	3	5
242	R:R:F363	R:R:L364	2.44	No	Yes	0	3	3
243	R:R:F363	R:R:L367	2.44	No	No	0	3	5
244	R:R:F100	R:R:N373	2.42	Yes	No	0	4	5
245	R:R:F393	R:R:N137	2.42	Yes	No	0	9	8
246	R:R:D198	R:R:R201	2.38	No	No	0	8	5
247	R:R:L360	R:R:Y350	2.34	No	Yes	0	2	2
248	R:R:G135	R:R:P215	2.03	Yes	No	3	7	1
249	R:R:C90	R:R:G92	1.96	Yes	No	0	7	4
250	R:R:A385	R:R:C327	1.81	No	No	0	7	5
251	R:R:A183	R:R:A233	1.79	No	No	0	6	7
252	R:R:G118	R:R:I117	1.76	No	No	0	8	5
253	R:R:G135	R:R:I138	1.76	Yes	No	0	7	6
254	R:R:G115	R:R:L114	1.71	No	No	0	8	5
255	R:R:C327	R:R:V331	1.71	No	No	0	5	6
256	R:R:C335	R:R:V331	1.71	No	No	0	8	6
257	R:R:A381	R:R:V331	1.7	No	No	0	6	6
258	R:R:A400	R:R:T121	1.68	No	No	0	6	6
259	R:R:D246	R:R:G249	1.68	No	No	0	1	3
260	R:R:E172	R:R:G170	1.64	No	No	0	1	8
261	R:R:A141	R:R:I126	1.62	No	No	0	7	7
262	R:R:A141	R:R:I138	1.62	No	No	0	7	6
263	R:R:A322	R:R:M296	1.61	No	No	0	7	8
264	R:R:V223	R:R:V227	1.6	No	No	0	3	4
265	R:R:V227	R:R:V231	1.6	No	No	0	4	4
266	R:R:T105	R:R:V106	1.59	No	No	0	6	6
267	R:R:C380	R:R:L377	1.59	No	No	0	8	6
268	R:R:I96	R:R:S362	1.55	No	No	0	5	3
269	R:R:I116	R:R:S120	1.55	No	No	0	7	4
270	R:R:I153	R:R:V152	1.54	No	No	0	5	5
271	R:R:I103	R:R:T99	1.52	No	No	0	5	5
272	R:R:I344	R:R:T348	1.52	No	No	0	6	4
273	R:R:F169	R:R:G170	1.51	Yes	No	0	7	8
274	R:R:A194	R:R:E221	1.51	No	No	0	7	6
275	R:R:K262	R:R:T263	1.5	No	No	0	1	3
276	R:R:L163	R:R:V159	1.49	No	No	0	4	7
277	R:R:I116	R:R:I117	1.47	No	No	0	7	5
278	R:R:L347	R:R:T348	1.47	No	No	0	5	4
279	R:R:I384	R:R:L114	1.43	No	No	0	7	5
280	R:R:I180	R:R:L149	1.43	No	No	0	5	7
281	R:R:I180	R:R:L176	1.43	No	No	0	5	5
282	R:R:E221	R:R:V220	1.43	No	No	0	6	3
283	R:R:I384	R:R:L388	1.43	No	No	0	7	6
284	R:R:Q267	R:R:T271	1.42	No	No	0	1	4
285	R:R:K304	R:R:L301	1.41	No	No	0	3	5
286	R:R:A272	R:R:F268	1.39	No	No	0	4	1
287	R:R:E320	R:R:K391	1.35	No	No	0	7	5
288	R:R:E299	R:R:L295	1.33	No	No	0	5	3
289	R:R:N351	R:R:Q352	1.32	No	No	0	1	1
290	R:R:A272	R:R:W275	1.3	No	No	0	4	5
291	R:R:M245	R:R:Y247	1.2	No	No	0	1	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C90	5.2625	4	2	7
2	R:R:F100	6.958	5	0	4
3	R:R:N119	5.985	4	0	9
4	R:R:Y124	5.4775	4	0	3
5	R:R:M132	7.1	4	0	7
6	R:R:G135	3.235	4	3	7
7	R:R:L139	4.002	5	0	7
8	R:R:H150	6.756	5	0	8
9	R:R:I155	4.122	5	0	7
10	R:R:W167	7.776	5	1	9
11	R:R:F169	3.3475	4	0	7
12	R:R:F179	3.6425	4	0	6
13	R:R:W226	6.605	4	0	9
14	R:R:E236	9.328	5	1	5
15	R:R:H258	6.5025	4	0	4
16	R:R:Q261	4.636	5	0	2
17	R:R:M266	5.2075	4	0	4
18	R:R:Y269	7.2925	4	1	3
19	R:R:F278	6.425	4	4	6
20	R:R:F280	8.8725	4	0	5
21	R:R:F282	7.6675	4	4	8
22	R:R:F292	5.312	5	6	7
23	R:R:F332	4.406	5	4	9
24	R:R:W336	5.84167	6	4	8
25	R:R:H340	9.0975	4	4	8
26	R:R:Y350	6.42	4	2	2
27	R:R:R357	4.765	4	2	5
28	R:R:L364	5.1475	4	0	3
29	R:R:L386	4.528	5	5	9
30	R:R:F393	5.19667	6	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:R357	R:R:Y350	13.3766	7.2	Yes	Yes	2	5	2
2	R:R:L361	R:R:Y350	30.3409	9.38	No	Yes	0	3	2
3	R:R:L361	R:R:L365	31.6785	2.77	No	No	0	3	3
4	R:R:L365	R:R:Y369	32.63	5.86	No	No	0	3	3
5	R:R:F100	R:R:Y369	35.1822	19.6	Yes	No	0	4	3
6	R:R:F100	R:R:I370	47.7305	2.51	Yes	No	0	4	5
7	R:R:I370	R:R:M374	48.9114	2.92	No	No	0	5	7
8	R:R:M374	R:R:P338	50.07	6.71	No	No	0	7	9
9	R:R:L337	R:R:P338	51.2173	3.28	No	No	0	5	9
10	R:R:F282	R:R:L337	52.3535	3.65	Yes	No	0	8	5
11	R:R:F282	R:R:H340	53.5792	13.58	Yes	Yes	4	8	8
12	R:R:H340	R:R:W336	89.7577	8.46	Yes	Yes	4	8	8
13	R:R:F332	R:R:W336	90.9778	7.02	Yes	Yes	4	9	8
14	R:R:F332	R:R:T188	100	2.59	Yes	No	0	9	9
15	R:R:D147	R:R:T188	44.2324	4.34	No	No	0	9	9
16	R:R:D147	R:R:S379	43.4824	7.36	No	No	0	9	9
17	R:R:H150	R:R:S379	19.203	6.97	Yes	No	0	8	9
18	R:R:H150	R:R:I155	14.3617	6.63	Yes	Yes	0	8	7
19	R:R:I155	R:R:S108	12.3916	3.1	Yes	No	0	7	7
20	R:R:I151	R:R:S379	27.5312	3.1	No	No	0	6	9
21	R:R:I151	R:R:I155	18.6601	4.42	No	Yes	0	6	7
22	R:R:I151	R:R:N119	21.1283	2.83	No	Yes	0	6	9
23	R:R:N119	R:R:P383	12.6938	13.03	Yes	No	0	9	9
24	R:R:G118	R:R:P383	11.5184	4.06	No	No	0	8	9
25	R:R:A144	R:R:N119	12.9345	4.69	No	Yes	0	9	9
26	R:R:G118	R:R:I117	10.4494	1.76	No	No	0	8	5
27	R:R:L143	R:R:T188	69.0771	4.42	No	No	0	9	9
28	R:R:L143	R:R:N382	46.2753	2.75	No	No	0	9	9
29	R:R:L328	R:R:N382	45.3853	5.49	No	No	0	8	9
30	R:R:L328	R:R:L386	43.6671	5.54	No	Yes	5	8	9
31	R:R:F393	R:R:L386	39.878	8.53	Yes	Yes	5	9	9
32	R:R:F393	R:R:M132	28.3484	7.46	Yes	Yes	0	9	7
33	R:R:I125	R:R:M132	23.0201	2.92	No	Yes	0	7	7
34	R:R:F397	R:R:I125	20.2888	8.79	No	No	0	7	7
35	R:R:F397	R:R:T121	11.9046	3.89	No	No	0	7	6
36	R:R:L143	R:R:S191	33.9732	6.01	No	No	0	9	8
37	R:R:L139	R:R:S191	22.522	3	Yes	No	0	7	8
38	R:R:F393	R:R:N137	19.8522	2.42	Yes	No	0	9	8
39	R:R:N134	R:R:N137	18.5426	10.9	No	No	0	8	8
40	R:R:N134	R:R:P136	11.3561	8.15	No	No	3	8	8
41	R:R:P136	R:R:R199	10.1976	2.88	No	No	0	8	9
42	R:R:H340	R:R:L277	68.9931	6.43	Yes	No	0	8	6
43	R:R:K182	R:R:L277	67.6331	7.05	No	No	0	4	6
44	R:R:E236	R:R:K182	66.9111	9.45	Yes	No	0	5	4
45	R:R:E236	R:R:P178	18.9399	9.43	Yes	No	1	5	5
46	R:R:P178	R:R:V177	17.8821	5.3	No	No	0	5	5
47	R:R:V177	R:R:W167	15.7889	3.68	No	Yes	0	5	9
48	R:R:F169	R:R:W167	29.0256	4.01	Yes	Yes	0	7	9
49	R:R:F169	R:R:M173	19.3541	4.98	Yes	No	0	7	6
50	R:R:L176	R:R:M173	17.9493	2.83	No	No	0	5	6
51	R:R:I180	R:R:L176	16.7068	1.43	No	No	0	5	5
52	R:R:E236	R:R:F240	30.6935	9.33	Yes	No	1	5	5
53	R:R:C174	R:R:F240	29.7084	2.79	No	No	1	9	5
54	R:R:C174	R:R:W167	15.5146	3.92	No	Yes	1	9	9
55	R:R:C174	R:R:C255	13.1639	5.46	No	No	1	9	9
56	R:R:C255	R:R:I242	15.1117	3.27	No	No	0	9	5
57	R:R:I242	R:R:R253	11.6808	2.51	No	No	0	5	5
58	R:R:D166	R:R:R253	10.2591	5.96	No	No	0	5	5
59	R:R:F179	R:R:I180	11.0763	5.02	Yes	No	0	6	5
60	R:R:I225	R:R:S191	10.7461	3.1	No	No	0	7	8
61	R:R:F332	R:R:L192	20.0761	4.87	Yes	No	0	9	8
62	R:R:L192	R:R:V329	18.5985	5.96	No	No	0	8	8
63	R:R:F292	R:R:S196	12.5315	2.64	Yes	No	6	7	9
64	R:R:S196	R:R:T289	15.6098	4.8	No	No	0	9	8
65	R:R:T289	R:R:V329	17.1098	7.93	No	No	0	8	8
66	R:R:E236	R:R:K273	20.7589	9.45	Yes	No	1	5	7
67	R:R:K273	R:R:L257	20.3056	2.82	No	No	0	7	5
68	R:R:L257	R:R:Q261	17.8094	2.66	No	Yes	0	5	2
69	R:R:F280	R:R:W276	10.3431	14.03	Yes	No	0	5	4
70	R:R:L339	R:R:W336	10.7629	3.42	No	Yes	0	6	8
71	R:R:F278	R:R:I344	10.6845	5.02	Yes	No	0	6	6
72	R:R:C335	R:R:N378	10.802	4.72	No	No	0	8	9
73	R:R:F393	R:R:L122	10.8468	3.65	Yes	No	5	9	9
74	R:R:A144	R:R:L122	12.1621	4.73	No	No	0	9	9
75	R:R:F278	R:R:H340	11.5296	7.92	Yes	Yes	4	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9KDG

PDB Summary
PDB	9KDG
Class	A
SubFamily	Peptide
Type	Endothelin
SubType	ETB
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.33
Date	2025-05-07
D.O.I.	doi.org/10.1038/s41467-025-57960-x

Net Summary
I_min	2.59
Number of Linked Nodes	273
Number of Links	291
Number of Hubs	30
Number of Links mediated by Hubs	120
Number of Communities	7
Number of Nodes involved in Communities	37
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	37869
Length Of Smallest Path	3
Average Path Length	14.4456
Length of Longest Path	33
Minimum Path Strength	1.345
Average Path Strength	5.45874
Maximum Path Strength	13.98
Minimum Path Correlation	0.7
Average Path Correlation	0.931578
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	53.1154
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.8784
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • signaling receptor binding • isomerase activity • catalytic activity, acting on a protein • peptidyl-prolyl cis-trans isomerase activity • catalytic activity • cis-trans isomerase activity • FK506 binding • macrolide binding • channel regulator activity • ion channel regulator activity • calcium channel regulator activity • molecular function regulator activity • transporter regulator activity • transmembrane transporter binding • molecular function inhibitor activity • transporter inhibitor activity • calcium channel inhibitor activity • ion channel inhibitor activity • channel inhibitor activity • protein refolding • primary metabolic process • gene expression • macromolecule biosynthetic process • protein maturation • protein folding • biosynthetic process • metabolic process • cellular process • protein metabolic process • macromolecule metabolic process • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality
Gene Ontology	Biological Process	• protein refolding • primary metabolic process • gene expression • macromolecule biosynthetic process • protein maturation • protein folding • biosynthetic process • metabolic process • cellular process • protein metabolic process • macromolecule metabolic process • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of calcium ion transport • regulation of localization • regulation of cellular process • transport • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • negative regulation of biological process • negative regulation of transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • negative regulation of transmembrane transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • localization • negative regulation of monoatomic ion transmembrane transport • negative regulation of release of sequestered calcium ion into cytosol • negative regulation of cellular process • monoatomic ion transport • negative regulation of cation transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of biological process • calcium ion transmembrane import into cytosol • regulation of transport • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • establishment of localization • negative regulation of calcium ion transport • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • regulation of monoatomic cation transmembrane transport • negative regulation of calcium ion transmembrane transport • calcium ion transmembrane transport • response to stimulus • response to redox state • sarcoplasmic reticulum calcium ion transport • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • release of sequestered calcium ion into cytosol by endoplasmic reticulum • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • multicellular organismal process • system process • smooth muscle contraction • muscle contraction • muscle system process • cellular response to stimulus • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • establishment of protein localization • nitrogen compound transport • carbohydrate homeostasis • establishment of localization in cell • intracellular protein localization • regulation of hormone levels • establishment of protein localization to extracellular region • intracellular glucose homeostasis • protein secretion • cellular response to oxygen-containing compound • cellular response to carbohydrate stimulus • chemical homeostasis • response to glucose • response to chemical • glucose homeostasis • insulin secretion involved in cellular response to glucose stimulus • cellular localization • homeostatic process • hormone secretion • protein localization to extracellular region • peptide secretion • secretion by cell • response to monosaccharide • response to carbohydrate • signal release • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • secretion • cell-cell signaling • export from cell • response to oxygen-containing compound • cellular response to glucose stimulus • peptide transport • response to hexose • cellular response to chemical stimulus • cellular homeostasis • protein transport • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cell population proliferation • cell activation • lymphocyte activation • leukocyte proliferation • leukocyte activation • mononuclear cell proliferation • immune system process • T cell activation • lymphocyte proliferation • T cell proliferation • negative regulation of protein transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of response to stimulus • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • regulation of secretion by cell • negative regulation of protein localization • regulation of signaling • negative regulation of response to stimulus • regulation of peptide transport • negative regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of establishment of protein localization • regulation of protein transport • negative regulation of insulin secretion • regulation of cellular localization • regulation of insulin secretion • regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of cell communication • regulation of heart contraction • regulation of system process • cardiac muscle contraction • circulatory system process • regulation of cardiac muscle contraction • regulation of blood circulation • regulation of striated muscle contraction • regulation of muscle contraction • heart process • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • striated muscle contraction • regulation of multicellular organismal process • blood circulation • regulation of cardiac muscle contraction by calcium ion signaling • regulation of muscle system process • heart contraction • negative regulation of intracellular signal transduction • regulation of signal transduction • regulation of intracellular signal transduction • regulation of calcium-mediated signaling • negative regulation of calcium-mediated signaling • negative regulation of signal transduction • 'de novo' protein folding • negative regulation of heart rate • negative regulation of blood circulation • negative regulation of heart contraction • negative regulation of multicellular organismal process • regulation of heart rate • nervous system process • action potential propagation • action potential • transmission of nerve impulse • neuronal action potential propagation • regulation of membrane potential • cellular anatomical structure • membrane • intracellular anatomical structure • intracellular membraneless organelle • Z disc • sarcomere • intracellular organelle • I band • organelle • membraneless organelle • contractile muscle fiber • cytoplasm • supramolecular fiber • myofibril
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • intracellular anatomical structure • intracellular membraneless organelle • Z disc • sarcomere • intracellular organelle • I band • organelle • membraneless organelle • contractile muscle fiber • cytoplasm • supramolecular fiber • myofibril • supramolecular polymer • supramolecular complex • membrane-bounded organelle • organelle subcompartment • intracellular membrane-bounded organelle • endomembrane system • sarcoplasm • endoplasmic reticulum subcompartment • bounding membrane of organelle • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • sarcoplasmic reticulum • sarcoplasmic reticulum membrane • organelle membrane • endoplasmic reticulum membrane • protein-containing complex • transmembrane transporter complex • membrane protein complex • cation channel complex • transporter complex • calcium channel complex • monoatomic ion channel complex
SCOP2	Domain Identifier	• Rotamase-like
SCOP2	Family Identifier	• Rotamase-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P24530
Sequence	>9KDG_Chain_R C Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L I I Y K N K C M R N G P N I L I A S L A L G D L L H I V I I P I N V Y K L L A E D W P F G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A V P K W T A V E I V L I W V V S V V L A V P E A I G F D I I T M D Y K G S Y L R I C L L H P V Q K T A F M Q F Y T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L R I L K L T L Y N Q N D P N R C E L L S F L L V L D Y I G I N M A S L N S C N P I A L Y L V S K R F K N F K S L C C W Y A A A A A A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5GLH	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	2.8	2016-09-07	doi.org/10.1038/nature19319
	5GLI	A	Peptide	Endothelin	ET_B	Homo sapiens	-	-	-	2.5	2016-09-07	doi.org/10.1038/nature19319
	5X93	A	Peptide	Endothelin	ET_B	Homo sapiens	K-8794	-	-	2.2	2017-08-16	doi.org/10.1038/nsmb.3450
	5XPR	A	Peptide	Endothelin	ET_B	Homo sapiens	Bosentan	-	-	3.6	2017-08-16	doi.org/10.1038/nsmb.3450
	6IGK	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-3	-	-	2	2018-11-21	doi.org/10.1038/s41467-018-07094-0
	6IGL	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-	-	2.7	2018-11-21	doi.org/10.1038/s41467-018-07094-0
	6K1Q	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL2500	-	-	2.7	2019-07-17	doi.org/10.1038/s42003-019-0482-7
	6LRY	A	Peptide	Endothelin	ET_B	Homo sapiens	Sarafotoxin-B	-	-	3	2020-02-12	doi.org/10.1016/j.bbrc.2019.12.091
	8HBD	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-	Gi1/β1/γ2	2.99	2023-03-22	doi.org/10.1038/s41467-023-36998-9
	8HBD (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-		2.99	2023-03-22	doi.org/10.1038/s41467-023-36998-9
	8HCX	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.5	2023-03-22	doi.org/10.1038/s41467-023-36998-9
	8HCX (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		3.5	2023-03-22	doi.org/10.1038/s41467-023-36998-9
	8IY5	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/β1/γ2	2.8	2023-08-16	doi.org/10.7554/eLife.85821
	8IY5 (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		2.8	2023-08-16	doi.org/10.7554/eLife.85821
	8IY6	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	3.13	2023-08-16	doi.org/10.7554/eLife.85821
	8XVE	A	Peptide	Endothelin	ET_B	Homo sapiens	BQ3020	-	chim(Gs-CtGq)/β1/γ2	3	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVE (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	BQ3020	-		3	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVH	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	chim(Gs-CtGq)/β1/γ2	3.26	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVH (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		3.26	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XWP	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/β1/γ2	3.21	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWP (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		3.21	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWQ	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/β1/γ2	4.6	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWQ (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		4.6	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8ZRT	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	3.62	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	9KDF	A	Peptide	Endothelin	ET_B	Homo sapiens	RES-701-3	-	-	3.3	2025-05-07	doi.org/10.1038/s41467-025-57960-x

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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