Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:F14 4.195610
2L:L:D18 7.108510
3L:L:I19 7.404510
4L:L:W21 10.162500
5R:R:F100 5.495614
6R:R:K101 4.3925406
7R:R:N104 6.565415
8R:R:F112 5.365407
9R:R:L122 4.34409
10R:R:N129 6.05406
11R:R:R133 6.35507
12R:R:N134 4.615458
13R:R:N137 5.6225408
14R:R:L143 5.745409
15R:R:I151 3.7025406
16R:R:D154 8.64406
17R:R:W167 5.935639
18R:R:F169 4.0475407
19R:R:F179 4.79566
20R:R:I180 4.1875405
21R:R:I187 4.4475407
22R:R:D198 5.4825408
23R:R:Y200 6.7575408
24R:R:V228 2.2625414
25R:R:L232 5.025415
26R:R:I242 3.9625435
27R:R:Y247 4.86502
28R:R:I254 5.98404
29R:R:H258 10.79444
30R:R:Y269 12.6625413
31R:R:K273 6.338517
32R:R:D274 6.71415
33R:R:W276 7.338514
34R:R:F278 5.21426
35R:R:Y281 8.3925416
36R:R:F282 7.725428
37R:R:Y293 9.665409
38R:R:M296 3.48408
39R:R:W336 7.195628
40R:R:L339 3.925426
41R:R:R343 8.374516
42R:R:D368 9.16414
43R:R:Y369 6.016513
44R:R:Y387 10.305407
45R:R:F397 6.675407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:C15 L:L:F14 13.50254.19NoYes000
2L:L:C15 R:R:L256 11.64743.17NoNo004
3R:R:I254 R:R:L256 10.7718.56YesNo044
4R:R:I94 R:R:L365 15.25951.43NoNo043
5L:L:D18 L:L:F14 20.15137.17YesYes100
6L:L:D18 L:L:I19 32.17365.6YesYes100
7L:L:I19 R:R:N158 22.39887.08YesNo007
8L:L:I19 R:R:Y369 19.44727.25YesYes103
9L:L:I19 R:R:I372 25.2485.89YesNo006
10R:R:D274 R:R:K273 30.76324.15YesYes157
11R:R:K273 R:R:L257 37.01522.82YesNo075
12R:R:F240 R:R:L257 25.98919.74NoNo055
13R:R:F240 R:R:P178 25.027815.89NoNo055
14L:L:I20 R:R:P178 16.02033.39NoNo005
15L:L:I20 R:R:W167 14.13255.87NoYes009
16L:L:W21 R:R:R343 17.310813YesYes006
17L:L:W21 R:R:Q181 50.61588.76YesNo006
18L:L:W21 R:R:K182 15.878617.4YesNo004
19L:L:W21 R:R:V185 14.15433.68YesNo007
20L:L:W21 R:R:L277 11.85887.97YesNo006
21R:R:D154 R:R:N158 22.37710.77YesNo067
22R:R:D154 R:R:H150 1007.56YesNo068
23R:R:H150 R:R:S379 99.01034.18NoNo089
24R:R:I151 R:R:S379 16.91194.64YesNo069
25R:R:D154 R:R:I372 28.47648.4YesNo066
26R:R:D147 R:R:S379 87.41538.83NoNo099
27R:R:D147 R:R:N119 86.835412.12NoNo099
28R:R:A144 R:R:N119 84.48984.69NoNo099
29R:R:A144 R:R:L122 82.66523.15NoYes099
30R:R:F397 R:R:L122 77.14784.87YesYes079
31R:R:F397 R:R:I125 73.5645.02YesNo077
32R:R:I125 R:R:N129 71.46694.25NoYes076
33R:R:N129 R:R:N137 67.19864.09YesYes068
34R:R:N134 R:R:N137 58.5534.09YesYes088
35R:R:N134 R:R:P136 51.91298.15YesNo588
36R:R:D198 R:R:P136 51.59244.83YesNo088
37R:R:D198 R:R:L139 21.64458.14YesNo087
38R:R:L139 R:R:L195 19.86358.3NoNo079
39R:R:L232 R:R:W276 17.34146.83YesYes154
40R:R:L232 R:R:V228 24.97982.98YesYes154
41R:R:L190 R:R:V228 16.76152.98NoYes064
42R:R:I225 R:R:L190 15.104711.42NoNo076
43R:R:I187 R:R:I225 13.44362.94YesNo077
44R:R:V185 R:R:Y281 15.25086.31NoYes076
45R:R:L277 R:R:Y281 11.46645.86NoYes066
46R:R:W276 R:R:Y281 13.863.86YesYes146
47R:R:L195 R:R:R199 18.98512.15NoNo099
48R:R:R199 R:R:Y293 16.515211.32NoYes099
49R:R:D198 R:R:I197 25.47474.2YesNo086
50R:R:F292 R:R:I197 24.574411.3NoNo076
51R:R:F292 R:R:Y200 21.88436.19NoYes078
52R:R:M296 R:R:Y200 18.48154.79YesYes088
53L:L:S2 R:R:L257 11.43593NoNo005
54L:L:S2 R:R:K270 10.41793.06NoNo004
55R:R:D368 R:R:S342 13.20610.31YesNo045
56R:R:L364 R:R:S342 11.38363NoNo035
57R:R:M296 R:R:V321 15.18541.52YesNo088
58R:R:E236 R:R:K273 11.7158.1NoYes157
59L:L:D18 R:R:L365 13.45674.07YesNo103
60R:R:D274 R:R:R343 24.22783.57YesYes156
61R:R:E236 R:R:K182 15.442612.15NoNo054
62R:R:F280 R:R:Y281 11.795617.54NoYes156
63L:L:I19 R:R:D368 13.36311.2YesYes104
64R:R:D154 R:R:Q181 50.38047.83YesNo066
65R:R:F280 R:R:L232 10.85617.31NoYes155
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:L6 R:R:H258 9 4 No Yes 0 4 0 1
L:L:L6 R:R:P259 4.93 4 No No 0 6 0 1
L:L:Y13 R:R:Y247 7.94 0 No Yes 0 2 0 1
L:L:F14 R:R:K346 3.72 1 Yes No 0 4 0 1
L:L:F14 R:R:L361 3.65 1 Yes No 0 3 0 1
L:L:F14 R:R:L365 3.65 1 Yes No 0 3 0 1
L:L:C15 R:R:L256 3.17 0 No No 0 4 0 1
L:L:H16 R:R:I254 5.3 0 No Yes 0 4 0 1
L:L:L17 R:R:E165 6.63 0 No No 0 4 0 1
L:L:D18 R:R:R343 10.72 1 Yes Yes 0 6 0 1
L:L:D18 R:R:L365 4.07 1 Yes No 0 3 0 1
L:L:D18 R:R:D368 7.98 1 Yes Yes 0 4 0 1
L:L:I19 R:R:N158 7.08 1 Yes No 0 7 0 1
L:L:I19 R:R:D368 11.2 1 Yes Yes 0 4 0 1
L:L:I19 R:R:Y369 7.25 1 Yes Yes 0 3 0 1
L:L:I19 R:R:I372 5.89 1 Yes No 0 6 0 1
L:L:I20 R:R:K161 4.36 0 No No 0 5 0 1
L:L:I20 R:R:W167 5.87 0 No Yes 0 9 0 1
L:L:I20 R:R:P178 3.39 0 No No 0 5 0 1
L:L:W21 R:R:Q181 8.76 0 Yes No 0 6 0 1
L:L:W21 R:R:K182 17.4 0 Yes No 0 4 0 1
L:L:W21 R:R:V185 3.68 0 Yes No 0 7 0 1
L:L:W21 R:R:L277 7.97 0 Yes No 0 6 0 1
L:L:W21 R:R:R343 13 0 Yes Yes 0 6 0 1
R:R:P88 R:R:R357 10.09 0 No No 7 5 2 1
R:R:F100 R:R:I96 5.02 1 Yes No 4 5 2 2
R:R:I96 R:R:L162 4.28 1 No No 5 4 2 2
R:R:I96 R:R:Y369 3.63 1 No Yes 5 3 2 1
R:R:F100 R:R:N104 6.04 1 Yes Yes 4 5 2 2
R:R:F100 R:R:Y369 5.16 1 Yes Yes 4 3 2 1
R:R:N104 R:R:Y369 3.49 1 Yes Yes 5 3 2 1
R:R:D154 R:R:N158 10.77 0 Yes No 6 7 2 1
R:R:D154 R:R:Q181 7.83 0 Yes No 6 6 2 1
R:R:D154 R:R:I372 8.4 0 Yes No 6 6 2 1
R:R:I157 R:R:W167 3.52 0 No Yes 6 9 2 1
R:R:I157 R:R:V177 4.61 0 No No 6 5 2 2
R:R:L162 R:R:Y369 10.55 1 No Yes 4 3 2 1
R:R:F169 R:R:W167 7.02 0 Yes Yes 7 9 2 1
R:R:C174 R:R:W167 7.84 3 No Yes 9 9 2 1
R:R:I242 R:R:W167 3.52 3 Yes Yes 5 9 2 1
R:R:C255 R:R:W167 7.84 3 No Yes 9 9 2 1
R:R:C174 R:R:I242 6.55 3 No Yes 9 5 2 2
R:R:C174 R:R:C255 7.28 3 No No 9 9 2 2
R:R:P178 R:R:V177 3.53 0 No No 5 5 1 2
R:R:F240 R:R:P178 15.89 0 No No 5 5 2 1
R:R:E236 R:R:K182 12.15 1 No No 5 4 2 1
R:R:V185 R:R:Y281 6.31 0 No Yes 7 6 1 2
R:R:V185 R:R:W336 7.36 0 No Yes 7 8 1 2
R:R:E236 R:R:K273 8.1 1 No Yes 5 7 2 2
R:R:F240 R:R:L257 9.74 0 No No 5 5 2 1
R:R:D241 R:R:H258 17.65 0 No Yes 4 4 2 1
R:R:C255 R:R:I242 3.27 3 No Yes 9 5 2 2
R:R:I243 R:R:M245 7.29 0 No No 1 1 2 1
R:R:H258 R:R:I243 11.93 4 Yes No 4 1 1 2
R:R:K248 R:R:Y247 3.58 0 No Yes 1 2 2 1
R:R:S250 R:R:Y247 6.36 0 No Yes 1 2 2 1
R:R:L252 R:R:Y247 3.52 0 No Yes 3 2 2 1
R:R:I254 R:R:L252 7.14 0 Yes No 4 3 1 2
R:R:I254 R:R:L256 8.56 0 Yes No 4 4 1 1
R:R:H258 R:R:P259 4.58 4 Yes No 4 6 1 1
R:R:K270 R:R:Q267 4.07 0 No No 4 1 1 2
R:R:D274 R:R:K273 4.15 1 Yes Yes 5 7 2 2
R:R:D274 R:R:R343 3.57 1 Yes Yes 5 6 2 1
R:R:D274 R:R:K346 6.91 1 Yes No 5 4 2 1
R:R:L277 R:R:Y281 5.86 0 No Yes 6 6 1 2
R:R:L339 R:R:W336 3.42 2 Yes Yes 6 8 2 2
R:R:I372 R:R:L339 5.71 0 No Yes 6 6 1 2
R:R:D368 R:R:S342 10.31 1 Yes No 4 5 1 2
R:R:K346 R:R:R343 7.43 1 No Yes 4 6 1 1
R:R:D368 R:R:R343 7.15 1 Yes Yes 4 6 1 1
R:R:L361 R:R:Y350 7.03 0 No No 3 2 1 2
R:R:R357 R:R:Y350 3.09 0 No No 5 2 1 2
L:L:S2 R:R:K270 3.06 0 No No 0 4 0 1
L:L:V12 R:R:M245 3.04 0 No No 0 1 0 1
L:L:S2 R:R:L257 3 0 No No 0 5 0 1
R:R:I254 R:R:M245 2.92 0 Yes No 4 1 1 1
R:R:G249 R:R:Y247 2.9 0 No Yes 3 2 2 1
R:R:K273 R:R:L257 2.82 1 Yes No 7 5 2 1
L:L:E10 R:R:R357 2.33 0 No No 0 5 0 1
R:R:C358 R:R:I94 1.64 0 No No 8 4 2 1
L:L:L17 R:R:I94 1.43 0 No No 0 4 0 1
R:R:I94 R:R:L365 1.43 0 No No 4 3 1 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8XWP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.15
Number of Linked Nodes 301
Number of Links 343
Number of Hubs 45
Number of Links mediated by Hubs 167
Number of Communities 7
Number of Nodes involved in Communities 52
Number of Links involved in Communities 70
Path Summary
Number Of Nodes in MetaPath 66
Number Of Links MetaPath 65
Number of Shortest Paths 76326
Length Of Smallest Path 3
Average Path Length 17.4191
Length of Longest Path 39
Minimum Path Strength 1.17
Average Path Strength 6.17137
Maximum Path Strength 15.755
Minimum Path Correlation 0.7
Average Path Correlation 0.930717
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 43.9416
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.023
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP24530
Sequence
>8XWP_nogp_Chain_R
PPCQGPIEI KETFKYINT VVSCLVFVL GIIGNSTLL YIIYKNKCM 
RNGPNILIA SLALGDLLH IVIDIPINV YKLLAEDWP FGAEMCKLV 
PFIQKASVG ITVLSLCAL SIDRYRAVA SWSRIKGIG VPKWTAVEI 
VLIWVVSVV LAVPEAIGF DIITMDYKG SYLRICLLH PVQKTAFMQ 
FYKTAKDWW LFSFYFCLP LAITAFFYT LMTCEMLND HLKQRREVA 
KTVFCLVLV FALCWLPLH LSRILKLTL YNQNDPNRC ELLSFLLVL 
DYIGINMAS LNSCINPIA LYLVSKRFK NAFKS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6LRYAPeptideEndothelinETBHomo sapiensSarafotoxin-B--32020-02-12doi.org/10.1016/j.bbrc.2019.12.091
5GLHAPeptideEndothelinETBHomo sapiensEndothelin-1--2.82016-09-07doi.org/10.1038/nature19319
5GLIAPeptideEndothelinETBHomo sapiens---2.52016-09-07doi.org/10.1038/nature19319
5X93APeptideEndothelinETBHomo sapiensK-8794--2.22017-08-16doi.org/10.1038/nsmb.3450
5XPRAPeptideEndothelinETBHomo sapiensBosentan--3.62017-08-16doi.org/10.1038/nsmb.3450
6IGKAPeptideEndothelinETBHomo sapiensEndothelin-3--22018-11-21doi.org/10.1038/s41467-018-07094-0
6IGLAPeptideEndothelinETBHomo sapiensIRL1620--2.72018-11-21doi.org/10.1038/s41467-018-07094-0
8HBDAPeptideEndothelinETBHomo sapiensIRL1620-Gi1/β1/γ22.992023-03-22doi.org/10.1038/s41467-023-36998-9
8HBD (No Gprot) APeptideEndothelinETBHomo sapiensIRL1620-2.992023-03-22doi.org/10.1038/s41467-023-36998-9
8HCXAPeptideEndothelinETBHomo sapiensEndothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ23.52023-03-22doi.org/10.1038/s41467-023-36998-9
8HCX (No Gprot) APeptideEndothelinETBHomo sapiensEndothelin-1-3.52023-03-22doi.org/10.1038/s41467-023-36998-9
6K1QAPeptideEndothelinETBHomo sapiensIRL2500--2.72019-07-17doi.org/10.1038/s42003-019-0482-7
8IY5APeptideEndothelinETBHomo sapiensEndothelin-1-Gi1/β1/γ22.82023-08-16doi.org/10.7554/eLife.85821
8IY5 (No Gprot) APeptideEndothelinETBHomo sapiensEndothelin-1-2.82023-08-16doi.org/10.7554/eLife.85821
8IY6APeptideEndothelinETBHomo sapiensEndothelin-1--3.132023-08-16doi.org/10.7554/eLife.85821
8XVEAPeptideEndothelinETBHomo sapiensBQ3020-chim(Gs-CtGq)/β1/γ232024-08-28doi.org/10.1038/s41421-024-00705-9
8XVE (No Gprot) APeptideEndothelinETBHomo sapiensBQ3020-32024-08-28doi.org/10.1038/s41421-024-00705-9
8XVHAPeptideEndothelinETBHomo sapiensEndothelin-1-chim(Gs-CtGq)/β1/γ23.262024-08-28doi.org/10.1038/s41421-024-00705-9
8XVH (No Gprot) APeptideEndothelinETBHomo sapiensEndothelin-1-3.262024-08-28doi.org/10.1038/s41421-024-00705-9
9KDFAPeptideEndothelinETBHomo sapiensRES-701-3--3.32025-05-07doi.org/10.1038/s41467-025-57960-x
9KDGAPeptideEndothelinETBHomo sapiens---3.332025-05-07doi.org/10.1038/s41467-025-57960-x
8XWPAPeptideEndothelinETBHomo sapiensEndothelin-1-Gi1/β1/γ23.212024-10-02doi.org/10.1038/s42003-024-06905-z
8XWP (No Gprot) APeptideEndothelinETBHomo sapiensEndothelin-1-3.212024-10-02doi.org/10.1038/s42003-024-06905-z
8XWQAPeptideEndothelinETBHomo sapiensEndothelin-1-Gi1/β1/γ24.62024-10-02doi.org/10.1038/s42003-024-06905-z
8XWQ (No Gprot) APeptideEndothelinETBHomo sapiensEndothelin-1-4.62024-10-02doi.org/10.1038/s42003-024-06905-z
8ZRTAPeptideEndothelinETBHomo sapiensET-1--3.622024-10-02doi.org/10.1038/s42003-024-06905-z




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