psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:C15	7.28	No	No	0	0	0
2	L:L:C11	L:L:C3	7.28	No	No	1	0	0
3	L:L:D8	L:L:S5	4.42	No	No	0	0	0
4	L:L:L6	R:R:H258	9	No	Yes	4	0	4
5	L:L:L6	R:R:P259	4.93	No	No	4	0	6
6	L:L:H16	L:L:Y13	3.27	No	No	0	0	0
7	L:L:L17	L:L:Y13	5.86	No	No	0	0	0
8	L:L:Y13	R:R:Y247	7.94	No	Yes	0	0	2
9	L:L:C15	L:L:F14	4.19	No	Yes	0	0	0
10	L:L:D18	L:L:F14	7.17	Yes	Yes	1	0	0
11	L:L:F14	R:R:K346	3.72	Yes	No	1	0	4
12	L:L:F14	R:R:L361	3.65	Yes	No	0	0	3
13	L:L:F14	R:R:L365	3.65	Yes	No	1	0	3
14	L:L:C15	R:R:L256	3.17	No	No	0	0	4
15	L:L:H16	R:R:I254	5.3	No	Yes	0	0	4
16	L:L:L17	R:R:E165	6.63	No	No	0	0	4
17	L:L:D18	L:L:I19	5.6	Yes	Yes	1	0	0
18	L:L:D18	R:R:R343	10.72	Yes	Yes	1	0	6
19	L:L:D18	R:R:L365	4.07	Yes	No	1	0	3
20	L:L:D18	R:R:D368	7.98	Yes	Yes	1	0	4
21	L:L:I19	R:R:N158	7.08	Yes	No	0	0	7
22	L:L:I19	R:R:D368	11.2	Yes	Yes	1	0	4
23	L:L:I19	R:R:Y369	7.25	Yes	Yes	1	0	3
24	L:L:I19	R:R:I372	5.89	Yes	No	0	0	6
25	L:L:I20	R:R:K161	4.36	No	No	0	0	5
26	L:L:I20	R:R:W167	5.87	No	Yes	0	0	9
27	L:L:I20	R:R:P178	3.39	No	No	0	0	5
28	L:L:W21	R:R:Q181	8.76	Yes	No	0	0	6
29	L:L:W21	R:R:K182	17.4	Yes	No	0	0	4
30	L:L:W21	R:R:V185	3.68	Yes	No	0	0	7
31	L:L:W21	R:R:L277	7.97	Yes	No	0	0	6
32	L:L:W21	R:R:R343	13	Yes	Yes	0	0	6
33	R:R:N353	R:R:P88	9.77	No	No	0	1	7
34	R:R:P88	R:R:R357	10.09	No	No	0	7	5
35	R:R:C358	R:R:C90	7.28	No	No	0	8	7
36	R:R:G92	R:R:P93	4.06	No	No	0	4	4
37	R:R:F100	R:R:I96	5.02	Yes	No	1	4	5
38	R:R:I96	R:R:L162	4.28	No	No	1	5	4
39	R:R:I96	R:R:Y369	3.63	No	Yes	1	5	3
40	R:R:E98	R:R:K101	9.45	No	Yes	0	3	6
41	R:R:F100	R:R:N104	6.04	Yes	Yes	1	4	5
42	R:R:F100	R:R:V366	10.49	Yes	No	0	4	1
43	R:R:F100	R:R:Y369	5.16	Yes	Yes	1	4	3
44	R:R:F100	R:R:I370	5.02	Yes	No	0	4	5
45	R:R:K101	R:R:L162	4.23	Yes	No	0	6	4
46	R:R:N104	R:R:S108	4.47	Yes	No	1	5	7
47	R:R:N104	R:R:Y369	3.49	Yes	Yes	1	5	3
48	R:R:N104	R:R:N373	12.26	Yes	No	1	5	5
49	R:R:S108	R:R:V159	3.23	No	No	0	7	7
50	R:R:N373	R:R:S108	5.96	No	No	1	5	7
51	R:R:S376	R:R:V111	4.85	No	No	0	7	8
52	R:R:F112	R:R:I116	8.79	Yes	No	0	7	7
53	R:R:F112	R:R:I151	3.77	Yes	Yes	0	7	6
54	R:R:F112	R:R:I155	6.28	Yes	No	0	7	7
55	R:R:C380	R:R:L114	4.76	No	No	0	8	5
56	R:R:C380	R:R:G115	3.92	No	No	0	8	8
57	R:R:A144	R:R:N119	4.69	No	No	0	9	9
58	R:R:D147	R:R:N119	12.12	No	No	0	9	9
59	R:R:L148	R:R:N119	4.12	No	No	0	7	9
60	R:R:S120	R:R:Y124	3.82	No	No	0	4	3
61	R:R:F397	R:R:T121	6.49	Yes	No	0	7	6
62	R:R:A144	R:R:L122	3.15	No	Yes	0	9	9
63	R:R:L122	R:R:P383	6.57	Yes	No	0	9	9
64	R:R:F397	R:R:L122	4.87	Yes	Yes	0	7	9
65	R:R:A144	R:R:L123	3.15	No	No	0	9	7
66	R:R:I125	R:R:N129	4.25	No	Yes	0	7	6
67	R:R:A396	R:R:I125	4.87	No	No	0	4	7
68	R:R:F397	R:R:I125	5.02	Yes	No	0	7	7
69	R:R:I126	R:R:N137	7.08	No	Yes	0	7	8
70	R:R:A141	R:R:I126	4.87	No	No	0	7	7
71	R:R:K130	R:R:Y127	3.58	No	No	0	6	2
72	R:R:N129	R:R:N137	4.09	Yes	Yes	0	6	8
73	R:R:N129	R:R:R392	14.46	Yes	No	0	6	6
74	R:R:K130	R:R:R133	3.71	No	Yes	0	6	7
75	R:R:M132	R:R:R392	4.96	No	No	0	7	6
76	R:R:N137	R:R:R133	7.23	Yes	Yes	0	8	7
77	R:R:I138	R:R:R133	11.27	No	Yes	0	6	7
78	R:R:R133	R:R:V214	6.54	Yes	No	0	7	6
79	R:R:G135	R:R:N134	3.39	No	Yes	5	7	8
80	R:R:N134	R:R:P136	8.15	Yes	No	5	8	8
81	R:R:N134	R:R:N137	4.09	Yes	Yes	0	8	8
82	R:R:G135	R:R:P136	4.06	No	No	5	7	8
83	R:R:G135	R:R:P215	4.06	No	No	0	7	1
84	R:R:D198	R:R:P136	4.83	Yes	No	0	8	8
85	R:R:A194	R:R:L139	3.15	No	No	0	7	7
86	R:R:L139	R:R:L195	8.3	No	No	0	7	9
87	R:R:D198	R:R:L139	8.14	Yes	No	0	8	7
88	R:R:I140	R:R:L386	5.71	No	No	0	8	9
89	R:R:L143	R:R:S191	9.01	Yes	No	0	9	8
90	R:R:L143	R:R:L192	4.15	Yes	No	0	9	8
91	R:R:L143	R:R:N382	6.87	Yes	No	0	9	9
92	R:R:G146	R:R:I187	3.53	No	Yes	0	8	7
93	R:R:D147	R:R:S379	8.83	No	No	0	9	9
94	R:R:I180	R:R:L149	4.28	Yes	No	0	5	7
95	R:R:D154	R:R:H150	7.56	Yes	No	0	6	8
96	R:R:H150	R:R:S184	8.37	No	No	0	8	8
97	R:R:H150	R:R:S379	4.18	No	No	0	8	9
98	R:R:I151	R:R:S376	4.64	Yes	No	0	6	7
99	R:R:I151	R:R:S379	4.64	Yes	No	0	6	9
100	R:R:I153	R:R:I180	4.42	No	Yes	0	5	5
101	R:R:D154	R:R:N158	10.77	Yes	No	0	6	7
102	R:R:D154	R:R:Q181	7.83	Yes	No	0	6	6
103	R:R:D154	R:R:I372	8.4	Yes	No	0	6	6
104	R:R:I155	R:R:P156	3.39	No	No	0	7	9
105	R:R:I155	R:R:S376	4.64	No	No	0	7	7
106	R:R:I157	R:R:W167	3.52	No	Yes	0	6	9
107	R:R:I157	R:R:V177	4.61	No	No	0	6	5
108	R:R:A164	R:R:Y160	6.67	No	No	0	5	4
109	R:R:P168	R:R:Y160	8.34	No	No	0	2	4
110	R:R:L162	R:R:Y369	10.55	No	Yes	1	4	3
111	R:R:D166	R:R:R253	3.57	No	No	0	5	5
112	R:R:F169	R:R:W167	7.02	Yes	Yes	0	7	9
113	R:R:C174	R:R:W167	7.84	No	Yes	3	9	9
114	R:R:I242	R:R:W167	3.52	Yes	Yes	3	5	9
115	R:R:C255	R:R:W167	7.84	No	Yes	3	9	9
116	R:R:F169	R:R:M173	6.22	Yes	No	0	7	6
117	R:R:M173	R:R:V177	4.56	No	No	0	6	5
118	R:R:C174	R:R:I242	6.55	No	Yes	3	9	5
119	R:R:C174	R:R:C255	7.28	No	No	3	9	9
120	R:R:I180	R:R:L176	4.28	Yes	No	0	5	5
121	R:R:P178	R:R:V177	3.53	No	No	0	5	5
122	R:R:F240	R:R:P178	15.89	No	No	0	5	5
123	R:R:F179	R:R:I180	3.77	Yes	Yes	0	6	5
124	R:R:F179	R:R:V230	5.24	Yes	No	0	6	3
125	R:R:F179	R:R:V234	5.24	Yes	No	6	6	4
126	R:R:A237	R:R:F179	6.93	No	Yes	6	4	6
127	R:R:E236	R:R:K182	12.15	No	No	0	5	4
128	R:R:V185	R:R:Y281	6.31	No	Yes	0	7	6
129	R:R:V185	R:R:W336	7.36	No	Yes	0	7	8
130	R:R:G186	R:R:S229	3.71	No	No	0	6	8
131	R:R:I187	R:R:W226	8.22	Yes	No	0	7	9
132	R:R:P285	R:R:V189	7.07	No	No	0	9	8
133	R:R:I225	R:R:L190	11.42	No	No	0	7	6
134	R:R:C193	R:R:S196	3.44	No	No	0	8	9
135	R:R:C193	R:R:I288	3.27	No	No	0	8	7
136	R:R:L195	R:R:R199	12.15	No	No	0	9	9
137	R:R:S196	R:R:T289	6.4	No	No	0	9	8
138	R:R:S196	R:R:Y293	5.09	No	Yes	0	9	9
139	R:R:D198	R:R:I197	4.2	Yes	No	0	8	6
140	R:R:F292	R:R:I197	11.3	No	No	0	7	6
141	R:R:D198	R:R:R201	4.76	Yes	No	0	8	5
142	R:R:R199	R:R:Y293	11.32	No	Yes	0	9	9
143	R:R:L328	R:R:R199	3.64	No	No	0	8	9
144	R:R:A204	R:R:Y200	6.67	No	Yes	0	7	8
145	R:R:F292	R:R:Y200	6.19	No	Yes	0	7	8
146	R:R:L295	R:R:Y200	9.38	No	Yes	0	3	8
147	R:R:M296	R:R:Y200	4.79	Yes	Yes	0	8	8
148	R:R:R201	R:R:W217	12	No	No	0	5	5
149	R:R:P215	R:R:V214	3.53	No	No	0	1	6
150	R:R:P215	R:R:T218	15.74	No	No	0	1	7
151	R:R:K216	R:R:W217	4.64	No	No	0	3	5
152	R:R:E221	R:R:W217	13.08	No	No	0	6	5
153	R:R:I222	R:R:W226	4.7	No	No	0	7	9
154	R:R:L232	R:R:W276	6.83	Yes	Yes	1	5	4
155	R:R:F280	R:R:L232	7.31	No	Yes	1	5	5
156	R:R:P235	R:R:V234	3.53	No	No	0	8	4
157	R:R:A237	R:R:V234	3.39	No	No	6	4	4
158	R:R:P235	R:R:Y269	13.91	No	Yes	0	8	3
159	R:R:E236	R:R:Y269	10.1	No	Yes	1	5	3
160	R:R:E236	R:R:K273	8.1	No	Yes	1	5	7
161	R:R:I238	R:R:M266	7.29	No	No	0	5	4
162	R:R:G239	R:R:Q261	4.93	No	No	0	5	2
163	R:R:F240	R:R:L257	9.74	No	No	0	5	5
164	R:R:D241	R:R:H258	17.65	No	Yes	0	4	4
165	R:R:C255	R:R:I242	3.27	No	Yes	3	9	5
166	R:R:I243	R:R:M245	7.29	No	No	0	1	1
167	R:R:H258	R:R:I243	11.93	Yes	No	0	4	1
168	R:R:T244	R:R:Y251	12.48	No	No	0	1	5
169	R:R:D246	R:R:Y251	6.9	No	No	0	1	5
170	R:R:K248	R:R:Y247	3.58	No	Yes	0	1	2
171	R:R:S250	R:R:Y247	6.36	No	Yes	0	1	2
172	R:R:L252	R:R:Y247	3.52	No	Yes	0	3	2
173	R:R:I254	R:R:L252	7.14	Yes	No	0	4	3
174	R:R:I254	R:R:L256	8.56	Yes	No	0	4	4
175	R:R:H258	R:R:P259	4.58	Yes	No	4	4	6
176	R:R:M266	R:R:Q261	5.44	No	No	0	4	2
177	R:R:Q261	R:R:Q267	6.4	No	No	0	2	1
178	R:R:M266	R:R:T263	6.02	No	No	0	4	3
179	R:R:K270	R:R:Q267	4.07	No	No	0	4	1
180	R:R:K273	R:R:Y269	13.14	Yes	Yes	1	7	3
181	R:R:W276	R:R:Y269	13.5	Yes	Yes	1	4	3
182	R:R:D274	R:R:K273	4.15	Yes	Yes	1	5	7
183	R:R:K273	R:R:W276	3.48	Yes	Yes	1	7	4
184	R:R:D274	R:R:R343	3.57	Yes	Yes	1	5	6
185	R:R:D274	R:R:K346	6.91	Yes	No	1	5	4
186	R:R:D274	R:R:L347	12.21	Yes	No	0	5	5
187	R:R:I344	R:R:W275	8.22	No	No	0	6	5
188	R:R:L347	R:R:W275	7.97	No	No	0	5	5
189	R:R:F280	R:R:W276	9.02	No	Yes	1	5	4
190	R:R:W276	R:R:Y281	3.86	Yes	Yes	1	4	6
191	R:R:L277	R:R:Y281	5.86	No	Yes	0	6	6
192	R:R:F278	R:R:F282	7.5	Yes	Yes	2	6	8
193	R:R:F278	R:R:H340	5.66	Yes	No	2	6	8
194	R:R:F278	R:R:I344	6.28	Yes	No	0	6	6
195	R:R:F280	R:R:Y281	17.54	No	Yes	1	5	6
196	R:R:F282	R:R:L286	4.87	Yes	No	0	8	7
197	R:R:F282	R:R:L337	6.09	Yes	No	0	8	5
198	R:R:F282	R:R:H340	12.44	Yes	No	2	8	8
199	R:R:L284	R:R:P285	3.28	No	No	0	6	9
200	R:R:I288	R:R:L284	4.28	No	No	0	7	6
201	R:R:A333	R:R:L286	4.73	No	No	0	6	7
202	R:R:T289	R:R:V329	4.76	No	No	0	8	8
203	R:R:F291	R:R:F292	4.29	No	No	0	4	7
204	R:R:F291	R:R:L295	6.09	No	No	0	4	3
205	R:R:V325	R:R:Y293	20.19	No	Yes	0	8	9
206	R:R:F326	R:R:T294	5.19	No	No	0	5	4
207	R:R:M296	R:R:V325	6.09	Yes	No	0	8	8
208	R:R:A322	R:R:T297	3.36	No	No	0	7	5
209	R:R:F326	R:R:T297	10.38	No	No	0	5	5
210	R:R:M300	R:R:R318	9.93	No	No	0	8	7
211	R:R:M300	R:R:V321	7.61	No	No	0	8	8
212	R:R:D313	R:R:K316	5.53	No	No	7	3	4
213	R:R:D313	R:R:Q317	7.83	No	No	7	3	5
214	R:R:L315	R:R:R319	8.5	No	No	0	4	5
215	R:R:K316	R:R:Q317	5.42	No	No	7	4	5
216	R:R:E320	R:R:Q317	8.92	No	No	0	7	5
217	R:R:T324	R:R:V389	4.76	No	No	0	8	7
218	R:R:I381	R:R:V331	6.14	No	No	0	6	6
219	R:R:F332	R:R:W336	8.02	No	Yes	2	9	8
220	R:R:F332	R:R:N378	8.46	No	No	2	9	9
221	R:R:C335	R:R:N378	3.15	No	No	0	8	9
222	R:R:L339	R:R:W336	3.42	Yes	Yes	2	6	8
223	R:R:H340	R:R:W336	5.29	No	Yes	2	8	8
224	R:R:A375	R:R:W336	7.78	No	Yes	2	8	8
225	R:R:N378	R:R:W336	11.3	No	Yes	2	9	8
226	R:R:G371	R:R:P338	4.06	No	No	0	7	9
227	R:R:M374	R:R:P338	3.35	No	No	0	7	9
228	R:R:G371	R:R:L339	3.42	No	Yes	0	7	6
229	R:R:I372	R:R:L339	5.71	No	Yes	0	6	6
230	R:R:A375	R:R:L339	3.15	No	Yes	2	8	6
231	R:R:L341	R:R:L345	4.15	No	No	0	6	5
232	R:R:L367	R:R:S342	6.01	No	No	0	5	5
233	R:R:D368	R:R:S342	10.31	Yes	No	0	4	5
234	R:R:K346	R:R:R343	7.43	No	Yes	1	4	6
235	R:R:D368	R:R:R343	7.15	Yes	Yes	1	4	6
236	R:R:L361	R:R:Y350	7.03	No	No	0	3	2
237	R:R:D354	R:R:N351	4.04	No	No	0	1	1
238	R:R:D354	R:R:P355	8.05	No	No	0	1	1
239	R:R:D354	R:R:N356	6.73	No	No	0	1	3
240	R:R:E359	R:R:N356	13.15	No	No	0	4	3
241	R:R:F363	R:R:S362	3.96	No	No	0	3	3
242	R:R:N382	R:R:P383	4.89	No	No	0	9	9
243	R:R:L388	R:R:Y387	8.21	No	Yes	0	6	7
244	R:R:K394	R:R:Y387	19.11	No	Yes	0	8	7
245	R:R:F397	R:R:Y387	10.32	Yes	Yes	0	7	7
246	R:R:K398	R:R:Y387	3.58	No	Yes	0	4	7
247	R:R:F393	R:R:R392	3.21	No	No	0	9	6
248	R:R:I222	R:R:S142	3.1	No	No	0	7	9
249	R:R:I187	R:R:S229	3.1	Yes	No	0	7	8
250	R:R:R357	R:R:Y350	3.09	No	No	0	5	2
251	L:L:S2	R:R:K270	3.06	No	No	0	0	4
252	R:R:C90	R:R:Q91	3.05	No	No	0	7	4
253	L:L:V12	R:R:M245	3.04	No	No	0	0	1
254	L:L:S2	R:R:L257	3	No	No	0	0	5
255	R:R:G213	R:R:R133	3	No	Yes	0	6	7
256	R:R:K323	R:R:T324	3	No	No	0	5	8
257	R:R:L364	R:R:S342	3	No	No	0	3	5
258	R:R:L190	R:R:V228	2.98	No	Yes	0	6	4
259	R:R:L232	R:R:V228	2.98	Yes	Yes	1	5	4
260	R:R:L232	R:R:V231	2.98	Yes	No	0	5	4
261	R:R:L143	R:R:T188	2.95	Yes	No	0	9	9
262	R:R:I187	R:R:I225	2.94	Yes	No	0	7	7
263	R:R:I254	R:R:M245	2.92	Yes	No	0	4	1
264	R:R:G249	R:R:Y247	2.9	No	Yes	0	3	2
265	R:R:K391	R:R:K394	2.87	No	No	0	5	8
266	R:R:I117	R:R:L114	2.85	No	No	0	5	5
267	R:R:E320	R:R:V321	2.85	No	No	0	7	8
268	R:R:I381	R:R:L377	2.85	No	No	0	6	6
269	R:R:I212	R:R:N134	2.83	No	Yes	0	3	8
270	R:R:K273	R:R:L257	2.82	Yes	No	0	7	5
271	R:R:E320	R:R:T324	2.82	No	No	0	7	8
272	L:L:C11	L:L:F14	2.79	No	Yes	1	0	0
273	R:R:L122	R:R:L386	2.77	Yes	No	0	9	9
274	R:R:L123	R:R:L145	2.77	No	No	0	7	6
275	R:R:A233	R:R:F179	2.77	No	Yes	0	7	6
276	R:R:L337	R:R:L341	2.77	No	No	0	5	6
277	R:R:L345	R:R:L349	2.77	No	No	0	5	3
278	R:R:L345	R:R:L364	2.77	No	No	0	5	3
279	R:R:L360	R:R:L364	2.77	No	No	0	2	3
280	R:R:F112	R:R:V113	2.62	Yes	No	0	7	5
281	R:R:R253	R:R:T244	2.59	No	No	0	5	1
282	R:R:F265	R:R:T263	2.59	No	No	0	3	3
283	R:R:I242	R:R:R253	2.51	Yes	No	0	5	5
284	R:R:K101	R:R:Y102	2.39	Yes	No	0	6	3
285	L:L:E10	R:R:R357	2.33	No	No	0	0	5
286	R:R:Q352	R:R:Y350	2.25	No	No	0	1	2
287	R:R:F326	R:R:Y293	2.06	No	Yes	0	5	9
288	R:R:C90	R:R:G92	1.96	No	No	0	7	4
289	R:R:P88	R:R:P89	1.95	No	No	0	7	3
290	R:R:G118	R:R:T121	1.82	No	No	0	8	6
291	R:R:G115	R:R:I151	1.76	No	Yes	0	8	6
292	R:R:G118	R:R:I117	1.76	No	No	0	8	5
293	R:R:G239	R:R:K175	1.74	No	No	0	5	7
294	R:R:G211	R:R:K210	1.74	No	No	0	3	4
295	R:R:A183	R:R:S229	1.71	No	No	0	6	8
296	R:R:C335	R:R:V331	1.71	No	No	0	8	6
297	R:R:A202	R:R:V203	1.7	No	No	0	8	9
298	R:R:A290	R:R:V329	1.7	No	No	0	5	8
299	R:R:C298	R:R:T294	1.69	No	No	0	4	4
300	R:R:C298	R:R:T297	1.69	No	No	0	4	5
301	R:R:C358	R:R:I94	1.64	No	No	0	8	4
302	R:R:C380	R:R:I384	1.64	No	No	0	8	7
303	R:R:C131	R:R:M132	1.62	No	No	0	5	7
304	R:R:S390	R:R:V389	1.62	No	No	0	8	7
305	R:R:V107	R:R:V111	1.6	No	No	0	5	8
306	R:R:V223	R:R:V227	1.6	No	No	0	3	4
307	R:R:V227	R:R:V228	1.6	No	Yes	1	4	4
308	R:R:A385	R:R:L328	1.58	No	No	0	7	8
309	L:L:C3	L:L:D8	1.56	No	No	1	0	0
310	L:L:C11	L:L:D8	1.56	No	No	1	0	0
311	R:R:A396	R:R:N395	1.56	No	No	0	4	4
312	R:R:I116	R:R:V152	1.54	No	No	0	7	5
313	L:L:M7	L:L:S5	1.53	No	No	0	0	0
314	R:R:M296	R:R:V203	1.52	Yes	No	0	8	9
315	R:R:M296	R:R:V321	1.52	Yes	No	0	8	8
316	R:R:I344	R:R:T348	1.52	No	No	0	6	4
317	R:R:F169	R:R:G170	1.51	Yes	No	0	7	8
318	R:R:A204	R:R:E299	1.51	No	No	0	7	5
319	R:R:K97	R:R:T99	1.5	No	No	0	3	5
320	R:R:K101	R:R:T105	1.5	Yes	No	0	6	6
321	R:R:L148	R:R:S120	1.5	No	No	0	7	4
322	R:R:K262	R:R:T263	1.5	No	No	0	1	3
323	R:R:L224	R:R:V220	1.49	No	No	0	3	3
324	R:R:L224	R:R:V227	1.49	No	No	1	3	4
325	R:R:L224	R:R:V228	1.49	No	Yes	1	3	4
326	R:R:L163	R:R:T105	1.47	No	No	0	4	6
327	R:R:I209	R:R:K210	1.45	No	No	0	6	4
328	R:R:I212	R:R:K210	1.45	No	No	0	3	4
329	R:R:F169	R:R:P168	1.44	Yes	No	0	7	2
330	R:R:E359	R:R:S362	1.44	No	No	0	4	3
331	L:L:L17	R:R:I94	1.43	No	No	0	0	4
332	R:R:I94	R:R:L365	1.43	No	No	0	4	3
333	R:R:K128	R:R:N129	1.4	No	Yes	0	4	6
334	R:R:C283	R:R:F278	1.4	No	Yes	0	5	6
335	R:R:L360	R:R:N356	1.37	No	No	0	2	3
336	L:L:E10	L:L:K9	1.35	No	No	0	0	0
337	R:R:E172	R:R:L176	1.33	No	No	0	1	5
338	R:R:R201	R:R:S205	1.32	No	No	0	5	7
339	R:R:A272	R:R:W275	1.3	No	No	0	4	5
340	R:R:F100	R:R:K97	1.24	Yes	No	0	4	3
341	R:R:L301	R:R:R318	1.21	No	No	0	5	7
342	R:R:L301	R:R:R319	1.21	No	No	0	5	5
343	R:R:H314	R:R:R318	1.13	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F14	4.195	6	1	0
2	L:L:D18	7.108	5	1	0
3	L:L:I19	7.404	5	1	0
4	L:L:W21	10.162	5	0	0
5	R:R:F100	5.495	6	1	4
6	R:R:K101	4.3925	4	0	6
7	R:R:N104	6.565	4	1	5
8	R:R:F112	5.365	4	0	7
9	R:R:L122	4.34	4	0	9
10	R:R:N129	6.05	4	0	6
11	R:R:R133	6.35	5	0	7
12	R:R:N134	4.615	4	5	8
13	R:R:N137	5.6225	4	0	8
14	R:R:L143	5.745	4	0	9
15	R:R:I151	3.7025	4	0	6
16	R:R:D154	8.64	4	0	6
17	R:R:W167	5.935	6	3	9
18	R:R:F169	4.0475	4	0	7
19	R:R:F179	4.79	5	6	6
20	R:R:I180	4.1875	4	0	5
21	R:R:I187	4.4475	4	0	7
22	R:R:D198	5.4825	4	0	8
23	R:R:Y200	6.7575	4	0	8
24	R:R:V228	2.2625	4	1	4
25	R:R:L232	5.025	4	1	5
26	R:R:I242	3.9625	4	3	5
27	R:R:Y247	4.86	5	0	2
28	R:R:I254	5.98	4	0	4
29	R:R:H258	10.79	4	4	4
30	R:R:Y269	12.6625	4	1	3
31	R:R:K273	6.338	5	1	7
32	R:R:D274	6.71	4	1	5
33	R:R:W276	7.338	5	1	4
34	R:R:F278	5.21	4	2	6
35	R:R:Y281	8.3925	4	1	6
36	R:R:F282	7.725	4	2	8
37	R:R:Y293	9.665	4	0	9
38	R:R:M296	3.48	4	0	8
39	R:R:W336	7.195	6	2	8
40	R:R:L339	3.925	4	2	6
41	R:R:R343	8.374	5	1	6
42	R:R:D368	9.16	4	1	4
43	R:R:Y369	6.016	5	1	3
44	R:R:Y387	10.305	4	0	7
45	R:R:F397	6.675	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C15	L:L:F14	13.5066	4.19	No	Yes	0	0	0
2	L:L:C15	R:R:L256	11.6509	3.17	No	No	0	0	4
3	R:R:I254	R:R:L256	10.7743	8.56	Yes	No	0	4	4
4	R:R:I94	R:R:L365	15.2642	1.43	No	No	0	4	3
5	L:L:D18	L:L:F14	20.1574	7.17	Yes	Yes	1	0	0
6	L:L:D18	L:L:I19	32.1834	5.6	Yes	Yes	1	0	0
7	L:L:I19	R:R:N158	22.4056	7.08	Yes	No	0	0	7
8	L:L:I19	R:R:Y369	19.4531	7.25	Yes	Yes	1	0	3
9	L:L:I19	R:R:I372	25.2557	5.89	Yes	No	0	0	6
10	R:R:D274	R:R:K273	30.7726	4.15	Yes	Yes	1	5	7
11	R:R:K273	R:R:L257	36.9938	2.82	Yes	No	0	7	5
12	R:R:F240	R:R:L257	25.9971	9.74	No	No	0	5	5
13	R:R:F240	R:R:P178	25.0354	15.89	No	No	0	5	5
14	L:L:I20	R:R:P178	16.0252	3.39	No	No	0	0	5
15	L:L:I20	R:R:W167	14.1368	5.87	No	Yes	0	0	9
16	L:L:W21	R:R:R343	17.3161	13	Yes	Yes	0	0	6
17	L:L:W21	R:R:Q181	50.6008	8.76	Yes	No	0	0	6
18	L:L:W21	R:R:K182	15.8529	17.4	Yes	No	0	0	4
19	L:L:W21	R:R:V185	14.1586	3.68	Yes	No	0	0	7
20	L:L:W21	R:R:L277	11.8624	7.97	Yes	No	0	0	6
21	R:R:D154	R:R:N158	22.3838	10.77	Yes	No	0	6	7
22	R:R:D154	R:R:H150	100	7.56	Yes	No	0	6	8
23	R:R:H150	R:R:S379	99.01	4.18	No	No	0	8	9
24	R:R:I151	R:R:S379	16.9149	4.64	Yes	No	0	6	9
25	R:R:D154	R:R:I372	28.4851	8.4	Yes	No	0	6	6
26	R:R:D147	R:R:S379	87.4136	8.83	No	No	0	9	9
27	R:R:D147	R:R:N119	86.8336	12.12	No	No	0	9	9
28	R:R:A144	R:R:N119	84.4872	4.69	No	No	0	9	9
29	R:R:A144	R:R:L122	82.6621	3.15	No	Yes	0	9	9
30	R:R:F397	R:R:L122	77.1452	4.87	Yes	Yes	0	7	9
31	R:R:F397	R:R:I125	73.5624	5.02	Yes	No	0	7	7
32	R:R:I125	R:R:N129	71.4647	4.25	No	Yes	0	7	6
33	R:R:N129	R:R:N137	67.1973	4.09	Yes	Yes	0	6	8
34	R:R:N134	R:R:N137	58.5512	4.09	Yes	Yes	0	8	8
35	R:R:N134	R:R:P136	51.9091	8.15	Yes	No	5	8	8
36	R:R:D198	R:R:P136	51.5886	4.83	Yes	No	0	8	8
37	R:R:D198	R:R:L139	21.6424	8.14	Yes	No	0	8	7
38	R:R:L139	R:R:L195	19.8631	8.3	No	No	0	7	9
39	R:R:L232	R:R:W276	17.3466	6.83	Yes	Yes	1	5	4
40	R:R:L232	R:R:V228	24.9875	2.98	Yes	Yes	1	5	4
41	R:R:L190	R:R:V228	16.7666	2.98	No	Yes	0	6	4
42	R:R:I225	R:R:L190	15.1094	11.42	No	No	0	7	6
43	R:R:I187	R:R:I225	13.4477	2.94	Yes	No	0	7	7
44	R:R:V185	R:R:Y281	15.2555	6.31	No	Yes	0	7	6
45	R:R:L277	R:R:Y281	11.4699	5.86	No	Yes	0	6	6
46	R:R:W276	R:R:Y281	13.8642	3.86	Yes	Yes	1	4	6
47	R:R:L195	R:R:R199	18.9843	12.15	No	No	0	9	9
48	R:R:R199	R:R:Y293	16.518	11.32	No	Yes	0	9	9
49	R:R:D198	R:R:I197	25.4759	4.2	Yes	No	0	8	6
50	R:R:F292	R:R:I197	24.5753	11.3	No	No	0	7	6
51	R:R:F292	R:R:Y200	21.8845	6.19	No	Yes	0	7	8
52	R:R:M296	R:R:Y200	18.4806	4.79	Yes	Yes	0	8	8
53	L:L:S2	R:R:L257	11.4394	3	No	No	0	0	5
54	L:L:S2	R:R:K270	10.4211	3.06	No	No	0	0	4
55	R:R:D368	R:R:S342	13.2101	10.31	Yes	No	0	4	5
56	R:R:L364	R:R:S342	11.3871	3	No	No	0	3	5
57	R:R:M296	R:R:V321	15.1857	1.52	Yes	No	0	8	8
58	R:R:E236	R:R:K273	11.6858	8.1	No	Yes	1	5	7
59	L:L:D18	R:R:L365	13.4608	4.07	Yes	No	1	0	3
60	R:R:D274	R:R:R343	24.2352	3.57	Yes	Yes	1	5	6
61	R:R:E236	R:R:K182	15.4146	12.15	No	No	0	5	4
62	R:R:F280	R:R:Y281	11.7992	17.54	No	Yes	1	5	6
63	L:L:I19	R:R:D368	13.3671	11.2	Yes	Yes	1	0	4
64	R:R:D154	R:R:Q181	50.3652	7.83	Yes	No	0	6	6
65	R:R:F280	R:R:L232	10.8594	7.31	No	Yes	1	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:L6	R:R:H258	9	4	No	Yes	0	4	0	1
L:L:L6	R:R:P259	4.93	4	No	No	0	6	0	1
L:L:Y13	R:R:Y247	7.94	0	No	Yes	0	2	0	1
L:L:F14	R:R:K346	3.72	1	Yes	No	0	4	0	1
L:L:F14	R:R:L361	3.65	1	Yes	No	0	3	0	1
L:L:F14	R:R:L365	3.65	1	Yes	No	0	3	0	1
L:L:C15	R:R:L256	3.17	0	No	No	0	4	0	1
L:L:H16	R:R:I254	5.3	0	No	Yes	0	4	0	1
L:L:L17	R:R:E165	6.63	0	No	No	0	4	0	1
L:L:D18	R:R:R343	10.72	1	Yes	Yes	0	6	0	1
L:L:D18	R:R:L365	4.07	1	Yes	No	0	3	0	1
L:L:D18	R:R:D368	7.98	1	Yes	Yes	0	4	0	1
L:L:I19	R:R:N158	7.08	1	Yes	No	0	7	0	1
L:L:I19	R:R:D368	11.2	1	Yes	Yes	0	4	0	1
L:L:I19	R:R:Y369	7.25	1	Yes	Yes	0	3	0	1
L:L:I19	R:R:I372	5.89	1	Yes	No	0	6	0	1
L:L:I20	R:R:K161	4.36	0	No	No	0	5	0	1
L:L:I20	R:R:W167	5.87	0	No	Yes	0	9	0	1
L:L:I20	R:R:P178	3.39	0	No	No	0	5	0	1
L:L:W21	R:R:Q181	8.76	0	Yes	No	0	6	0	1
L:L:W21	R:R:K182	17.4	0	Yes	No	0	4	0	1
L:L:W21	R:R:V185	3.68	0	Yes	No	0	7	0	1
L:L:W21	R:R:L277	7.97	0	Yes	No	0	6	0	1
L:L:W21	R:R:R343	13	0	Yes	Yes	0	6	0	1
R:R:P88	R:R:R357	10.09	0	No	No	7	5	2	1
R:R:F100	R:R:I96	5.02	1	Yes	No	4	5	2	2
R:R:I96	R:R:L162	4.28	1	No	No	5	4	2	2
R:R:I96	R:R:Y369	3.63	1	No	Yes	5	3	2	1
R:R:F100	R:R:N104	6.04	1	Yes	Yes	4	5	2	2
R:R:F100	R:R:Y369	5.16	1	Yes	Yes	4	3	2	1
R:R:N104	R:R:Y369	3.49	1	Yes	Yes	5	3	2	1
R:R:D154	R:R:N158	10.77	0	Yes	No	6	7	2	1
R:R:D154	R:R:Q181	7.83	0	Yes	No	6	6	2	1
R:R:D154	R:R:I372	8.4	0	Yes	No	6	6	2	1
R:R:I157	R:R:W167	3.52	0	No	Yes	6	9	2	1
R:R:I157	R:R:V177	4.61	0	No	No	6	5	2	2
R:R:L162	R:R:Y369	10.55	1	No	Yes	4	3	2	1
R:R:F169	R:R:W167	7.02	0	Yes	Yes	7	9	2	1
R:R:C174	R:R:W167	7.84	3	No	Yes	9	9	2	1
R:R:I242	R:R:W167	3.52	3	Yes	Yes	5	9	2	1
R:R:C255	R:R:W167	7.84	3	No	Yes	9	9	2	1
R:R:C174	R:R:I242	6.55	3	No	Yes	9	5	2	2
R:R:C174	R:R:C255	7.28	3	No	No	9	9	2	2
R:R:P178	R:R:V177	3.53	0	No	No	5	5	1	2
R:R:F240	R:R:P178	15.89	0	No	No	5	5	2	1
R:R:E236	R:R:K182	12.15	1	No	No	5	4	2	1
R:R:V185	R:R:Y281	6.31	0	No	Yes	7	6	1	2
R:R:V185	R:R:W336	7.36	0	No	Yes	7	8	1	2
R:R:E236	R:R:K273	8.1	1	No	Yes	5	7	2	2
R:R:F240	R:R:L257	9.74	0	No	No	5	5	2	1
R:R:D241	R:R:H258	17.65	0	No	Yes	4	4	2	1
R:R:C255	R:R:I242	3.27	3	No	Yes	9	5	2	2
R:R:I243	R:R:M245	7.29	0	No	No	1	1	2	1
R:R:H258	R:R:I243	11.93	4	Yes	No	4	1	1	2
R:R:K248	R:R:Y247	3.58	0	No	Yes	1	2	2	1
R:R:S250	R:R:Y247	6.36	0	No	Yes	1	2	2	1
R:R:L252	R:R:Y247	3.52	0	No	Yes	3	2	2	1
R:R:I254	R:R:L252	7.14	0	Yes	No	4	3	1	2
R:R:I254	R:R:L256	8.56	0	Yes	No	4	4	1	1
R:R:H258	R:R:P259	4.58	4	Yes	No	4	6	1	1
R:R:K270	R:R:Q267	4.07	0	No	No	4	1	1	2
R:R:D274	R:R:K273	4.15	1	Yes	Yes	5	7	2	2
R:R:D274	R:R:R343	3.57	1	Yes	Yes	5	6	2	1
R:R:D274	R:R:K346	6.91	1	Yes	No	5	4	2	1
R:R:L277	R:R:Y281	5.86	0	No	Yes	6	6	1	2
R:R:L339	R:R:W336	3.42	2	Yes	Yes	6	8	2	2
R:R:I372	R:R:L339	5.71	0	No	Yes	6	6	1	2
R:R:D368	R:R:S342	10.31	1	Yes	No	4	5	1	2
R:R:K346	R:R:R343	7.43	1	No	Yes	4	6	1	1
R:R:D368	R:R:R343	7.15	1	Yes	Yes	4	6	1	1
R:R:L361	R:R:Y350	7.03	0	No	No	3	2	1	2
R:R:R357	R:R:Y350	3.09	0	No	No	5	2	1	2
L:L:S2	R:R:K270	3.06	0	No	No	0	4	0	1
L:L:V12	R:R:M245	3.04	0	No	No	0	1	0	1
L:L:S2	R:R:L257	3	0	No	No	0	5	0	1
R:R:I254	R:R:M245	2.92	0	Yes	No	4	1	1	1
R:R:G249	R:R:Y247	2.9	0	No	Yes	3	2	2	1
R:R:K273	R:R:L257	2.82	1	Yes	No	7	5	2	1
L:L:E10	R:R:R357	2.33	0	No	No	0	5	0	1
R:R:C358	R:R:I94	1.64	0	No	No	8	4	2	1
L:L:L17	R:R:I94	1.43	0	No	No	0	4	0	1
R:R:I94	R:R:L365	1.43	0	No	No	4	3	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XWP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	301
Number of Links	343
Number of Hubs	45
Number of Links mediated by Hubs	167
Number of Communities	7
Number of Nodes involved in Communities	52
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	76311
Length Of Smallest Path	3
Average Path Length	17.4187
Length of Longest Path	39
Minimum Path Strength	1.17
Average Path Strength	6.17117
Maximum Path Strength	15.755
Minimum Path Correlation	0.7
Average Path Correlation	0.930816
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	43.9324
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.0236
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• peptide receptor activity • molecular transducer activity • endothelin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • binding • peptide hormone binding • hormone binding • angiotensin receptor binding • protein binding • signaling receptor binding • type 1 angiotensin receptor binding • G protein-coupled receptor binding • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • biological regulation • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate
Gene Ontology	Biological Process	• heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • biological regulation • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • regulation of penile erection • regulation of reproductive process • reproductive process • multicellular organismal reproductive process • positive regulation of biological process • mating behavior • behavior • positive regulation of penile erection • positive regulation of multicellular organismal process • reproductive behavior • penile erection • copulation • positive regulation of reproductive process • cellular response to stimulus • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • canonical Wnt signaling pathway • cell communication • cellular process • signal transduction • Wnt signaling pathway • renal filtration cell differentiation • kidney epithelium development • cellular developmental process • glomerular epithelial cell differentiation • epithelial cell differentiation • renal system development • multicellular organism development • cell differentiation • anatomical structure development • nephron development • system development • nephron epithelium development • epithelial cell differentiation involved in kidney development • developmental process • epithelium development • animal organ development • glomerular epithelium development • tissue development • glomerulus development • cell differentiation involved in kidney development • podocyte differentiation • kidney development • regulation of systemic arterial blood pressure by renin-angiotensin • protein localization • renin secretion into blood stream • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • establishment of protein localization • cellular localization • nitrogen compound transport • transport • protein localization to extracellular region • localization • secretion by cell • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • signal release • cellular macromolecule localization • renal system process involved in regulation of systemic arterial blood pressure • renal system process • secretion • regulation of blood pressure • establishment of protein localization to extracellular region • cell-cell signaling • export from cell • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • protein secretion • establishment of localization • regulation of systemic arterial blood pressure • endocrine process • protein transport • macromolecule localization • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • renal absorption • renal albumin absorption • renal protein absorption • smooth muscle cell differentiation • digestive system development • tube development • muscle cell differentiation • digestive tract development • muscle structure development • enteric smooth muscle cell differentiation • monoatomic ion transmembrane transport • inorganic ion transmembrane transport • calcium ion transport • metal ion transport • inorganic cation transmembrane transport • transmembrane transport • monoatomic cation transmembrane transport • monoatomic ion transport • monoatomic cation transport • calcium ion transmembrane transport • pigmentation • developmental pigmentation • regulation of protein metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of macromolecule metabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • protein metabolic process • macromolecule metabolic process • regulation of metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • protein transmembrane transport • acute-phase response • regulation of defense response • regulation of heat generation • regulation of response to external stimulus • homeostatic process • heat generation • response to stress • regulation of response to stress • acute inflammatory response • fever generation • defense response • regulation of inflammatory response • response to external stimulus • multicellular organismal-level homeostasis • regulation of response to stimulus • temperature homeostasis • regulation of fever generation • regulation of acute inflammatory response • inflammatory response • nervous system development • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • pharynx development • chordate pharynx development • RNA metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • transcription by RNA polymerase II • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • negative regulation of DNA-templated transcription • negative regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • negative regulation of RNA metabolic process • response to sodium phosphate • response to chemical • response to salt • response to endothelin • response to hormone • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • renal sodium ion transport • renal sodium ion absorption • sodium ion transport • excretion • renal sodium excretion • sodium ion homeostasis • inorganic ion homeostasis • renal tubular secretion • chemical homeostasis • monoatomic ion homeostasis • monoatomic cation homeostasis • multicellular organismal response to stress • response to pain • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • regulation of pH • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of developmental process • cell development • regulation of cell differentiation • regulation of neuron maturation • regulation of cell development • neurogenesis • negative regulation of neuron maturation • neuron differentiation • negative regulation of cell differentiation • cell maturation • regulation of cell maturation • negative regulation of developmental process • developmental maturation • generation of neurons • negative regulation of cell development • anatomical structure maturation • neuron development • neuron maturation • negative regulation of cell maturation • regulation of neuron differentiation • vascular associated smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • muscle system process • smooth muscle contraction • vein smooth muscle contraction • cGMP-mediated signaling • epithelial fluid transport • transepithelial transport • fluid transport • pigment cell differentiation • melanocyte differentiation • regulation of body fluid levels • positive regulation of urine volume • regulation of urine volume • posterior midgut development • midgut development • biological process involved in interspecies interaction between organisms • response to lipid • response to other organism • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to oxygen-containing compound • response to biotic stimulus • cellular response to biotic stimulus • cellular response to chemical stimulus • response to bacterium • cellular response to lipid • response to external biotic stimulus • response to molecule of bacterial origin • calcium-mediated signaling • stem cell development • neural crest cell differentiation • neural crest cell development • mesenchyme development • mesenchymal cell migration • stem cell differentiation • ameboidal-type cell migration • cell migration • mesenchymal cell differentiation • cell motility • neural crest cell migration • regulation of molecular function • negative regulation of lyase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • vasodilation • endothelin receptor signaling pathway • regulation of epithelial cell proliferation • epithelial cell proliferation • endothelial cell differentiation • endothelium development • endothelial cell development • epithelial cell development • establishment of endothelial barrier • peripheral nervous system development • ketone metabolic process • regulation of hormone levels • steroid metabolic process • alcohol metabolic process • C21-steroid hormone metabolic process • hormone metabolic process • aldehyde metabolic process • mineralocorticoid metabolic process • aldosterone metabolic process • olefinic compound metabolic process • small molecule metabolic process • primary alcohol metabolic process • lipid metabolic process • cell chemotaxis • chemotaxis • macrophage chemotaxis • macrophage migration • leukocyte migration • taxis • immune system process • mononuclear cell migration • myeloid leukocyte migration • leukocyte chemotaxis • locomotion • enteric nervous system development • autonomic nervous system development • neuroblast migration • carbohydrate derivative metabolic process • proteoglycan metabolic process • glycoprotein metabolic process • heparin proteoglycan metabolic process • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • cellular anatomical structure • organelle • nuclear envelope • organelle membrane • cell periphery
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • cellular anatomical structure • organelle • nuclear envelope • organelle membrane • cell periphery • plasma membrane • bombesin receptor binding • protein binding • binding • signaling receptor binding • endothelin A receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • receptor ligand activity • hormone activity • endothelin B receptor binding • developmental process • multicellular organism development • multicellular organismal process • skeletal system development • connective tissue development • anatomical structure development • animal organ development • tissue development • cartilage development • system development • regulation of biosynthetic process • regulation of nitric oxide biosynthetic process • regulation of biological process • regulation of cellular process • biological regulation • positive regulation of biological process • reactive nitrogen species metabolic process • positive regulation of nitric oxide metabolic process • nitric oxide metabolic process • positive regulation of metabolic process • nitric oxide biosynthetic process • biosynthetic process • positive regulation of biosynthetic process • cellular process • metabolic process • regulation of nitric oxide metabolic process • positive regulation of nitric oxide biosynthetic process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • response to human chorionic gonadotropin • cellular response to human chorionic gonadotropin stimulus • response to stimulus • cellular response to gonadotropin stimulus • response to endogenous stimulus • response to gonadotropin • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • heart process • system process • regulation of heart contraction • regulation of system process • positive regulation of heart rate • positive regulation of blood circulation • positive regulation of heart contraction • circulatory system process • regulation of blood circulation • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • positive regulation of cell communication • positive regulation of signal transduction • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • positive regulation of signaling • regulation of animal organ morphogenesis • regulation of developmental process • regulation of odontogenesis • odontogenesis • positive regulation of odontogenesis • positive regulation of developmental process • anatomical structure morphogenesis • positive regulation of animal organ morphogenesis • animal organ morphogenesis • regulation of anatomical structure morphogenesis • cell surface receptor signaling pathway • canonical Wnt signaling pathway • Wnt signaling pathway • response to ketone • response to lipid • response to oxygen-containing compound • response to testosterone • dorsal/ventral pattern formation • pattern specification process • regionalization • positive regulation of DNA-binding transcription factor activity • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • positive regulation of molecular function • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of molecular function • regulation of gene expression • regulation of DNA-binding transcription factor activity • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • respiratory gaseous exchange by respiratory system • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • stem cell fate commitment • cellular developmental process • chordate embryonic development • mesenchyme development • embryo development • neural crest formation • embryo development ending in birth or egg hatching • cell differentiation • neural crest cell fate commitment • neural crest cell differentiation • epithelial to mesenchymal transition • stem cell differentiation • anatomical structure formation involved in morphogenesis • mesenchymal cell differentiation • cell fate commitment • positive regulation of organelle organization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of mitotic nuclear division • positive regulation of mitotic nuclear division • mitotic cell cycle • cellular component organization • regulation of mitotic cell cycle • positive regulation of cell cycle process • cellular component organization or biogenesis • cell cycle • regulation of cell cycle • cell cycle process • mitotic nuclear division • regulation of cell cycle process • organelle fission • positive regulation of nuclear division • regulation of organelle organization • positive regulation of cell cycle • organelle organization • nuclear division • mitotic cell cycle process • regulation of nuclear division • cellular response to metal ion • response to metal ion • cellular response to calcium ion • response to calcium ion • transport • monoatomic ion transmembrane transport • inorganic ion transmembrane transport • establishment of localization • calcium ion transport • metal ion transport • inorganic cation transmembrane transport • transmembrane transport • monoatomic cation transmembrane transport • localization • monoatomic ion transport • monoatomic cation transport • calcium ion transmembrane transport • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of biological process • negative regulation of cell communication • negative regulation of cellular process • negative regulation of phospholipase C/protein kinase C signal transduction • negative regulation of response to stimulus • negative regulation of signal transduction • phospholipase C/protein kinase C signal transduction • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • morphogenesis of a branching epithelium • response to glucocorticoid • response to corticosteroid • response to steroid hormone • response to dexamethasone • response to salt • signal transduction involved in regulation of gene expression • cellular response to follicle-stimulating hormone stimulus • response to follicle-stimulating hormone • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to toxic substance • response to toxic substance • muscle hypertrophy • regulation of muscle adaptation • positive regulation of cardiac muscle hypertrophy • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • regulation of muscle hypertrophy • muscle adaptation • positive regulation of muscle hypertrophy • cardiac muscle hypertrophy • cell population proliferation • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • rhythmic synaptic transmission • trans-synaptic signaling • modulation of chemical synaptic transmission • cell-cell signaling • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • rhythmic excitation • axon extension • axonogenesis • developmental growth • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell growth • cell morphogenesis • neurogenesis • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • neuron projection extension • plasma membrane bounded cell projection organization • developmental cell growth • growth • nervous system development • axon development • cell morphogenesis involved in neuron differentiation • developmental growth involved in morphogenesis • generation of neurons • neuron development • cellular response to xenobiotic stimulus • response to xenobiotic stimulus • negative regulation of RNA biosynthetic process • transcription by RNA polymerase II • negative regulation of nucleobase-containing compound metabolic process • negative regulation of macromolecule metabolic process • regulation of transcription by RNA polymerase II • negative regulation of DNA-templated transcription • negative regulation of transcription by RNA polymerase II • negative regulation of metabolic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of RNA metabolic process • response to prostaglandin • response to prostaglandin F • artery development • pharyngeal arch artery morphogenesis • pharyngeal system development • artery morphogenesis • response to peptide • cellular response to interleukin-1 • response to cytokine • cellular response to cytokine stimulus • response to interleukin-1 • noradrenergic neuron differentiation • ear morphogenesis • embryonic organ morphogenesis • middle ear morphogenesis • ear development • sensory organ development • embryonic morphogenesis • sensory organ morphogenesis • embryonic organ development • cellular response to nitrogen compound • cellular response to luteinizing hormone stimulus • response to luteinizing hormone • response to peptide hormone • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • superoxide metabolic process • superoxide anion generation • reactive oxygen species metabolic process • multi-multicellular organism process • maternal process involved in parturition • reproductive process • multicellular organismal reproductive process • parturition • multi-organism reproductive process • positive regulation of canonical NF-kappaB signal transduction • canonical NF-kappaB signal transduction • regulation of canonical NF-kappaB signal transduction • thyroid gland development • endocrine system development • gland development • regulation of systemic arterial blood pressure by endothelin • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • endocrine process • MAPK cascade • ERK1 and ERK2 cascade • vascular associated smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • smooth muscle contraction • vein smooth muscle contraction • response to activity • response to oxidative stress • response to ozone • response to stress • response to reactive oxygen species • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • nitrogen compound transport • secretion • regulation of hormone levels • export from cell • hormone secretion • peptide transport • peptide secretion • secretion by cell • amide transport • peptide hormone secretion • signal release • hormone transport • regulation of chemokine-mediated signaling pathway • response to chemokine • positive regulation of response to cytokine stimulus • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • positive regulation of chemokine-mediated signaling pathway • regulation of G protein-coupled receptor signaling pathway • regulation of cytokine-mediated signaling pathway • positive regulation of G protein-coupled receptor signaling pathway • regulation of response to cytokine stimulus • positive regulation of cytokine-mediated signaling pathway • regulation of localization • regulation of hormone secretion • negative regulation of transport • negative regulation of secretion • regulation of secretion by cell • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of transport • regulation of secretion • glomerular filtration • renal filtration • histamine transport • histamine secretion • cellular response to tumor necrosis factor • response to tumor necrosis factor • positive regulation of phosphorylation • regulation of catalytic activity • regulation of transferase activity • positive regulation of phosphate metabolic process • regulation of MAP kinase activity • positive regulation of protein serine/threonine kinase activity • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • positive regulation of MAPK cascade • regulation of protein metabolic process • regulation of MAPK cascade • positive regulation of kinase activity • regulation of kinase activity • regulation of protein serine/threonine kinase activity • macromolecule modification • regulation of phosphorus metabolic process • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of protein modification process • protein metabolic process • positive regulation of protein kinase activity • positive regulation of transferase activity • positive regulation of catalytic activity • regulation of protein kinase activity • regulation of phosphorylation • biological process involved in interspecies interaction between organisms • immune response • response to other organism • defense response • response to type II interferon • defense response to symbiont • response to external stimulus • cellular response to type II interferon • response to biotic stimulus • immune system process • defense response to other organism • innate immune response • response to external biotic stimulus • nitric oxide transport • renal sodium excretion • inorganic ion homeostasis • regulation of renal system process • homeostatic process • positive regulation of secretion • monoatomic ion homeostasis • monoatomic cation homeostasis • positive regulation of renal sodium excretion • excretion • sodium ion homeostasis • renal tubular secretion • regulation of renal sodium excretion • positive regulation of transport • chemical homeostasis • regulation of excretion • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • artery smooth muscle contraction • tonic smooth muscle contraction • regulation of non-canonical NF-kappaB signal transduction • non-canonical NF-kappaB signal transduction • positive regulation of non-canonical NF-kappaB signal transduction • response to amine • response to amphetamine • regulation of prostaglandin secretion • monocarboxylic acid transport • fatty acid transport • prostaglandin secretion • positive regulation of icosanoid secretion • carboxylic acid transport • lipid transport • regulation of fatty acid transport • organic acid transport • positive regulation of lipid transport • lipid export from cell • prostaglandin transport • regulation of lipid transport • positive regulation of secretion by cell • icosanoid transport • regulation of icosanoid secretion • positive regulation of prostaglandin secretion • icosanoid secretion • organic anion transport • lipid localization • positive regulation of lipid localization • positive regulation of organic acid transport • regulation of lipid localization • macromolecule localization • regulation of organic acid transport • positive regulation of fatty acid transport • positive regulation of cell size • regulation of cellular component size • regulation of cell size • negative regulation of gene expression • response to lipopolysaccharide • response to bacterium • response to molecule of bacterial origin • endothelin receptor signaling pathway involved in heart process • endothelin receptor signaling pathway • G protein-coupled receptor signaling pathway involved in heart process • muscle cell apoptotic process • smooth muscle cell apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of muscle cell apoptotic process • regulation of programmed cell death • cell death • regulation of smooth muscle cell apoptotic process • negative regulation of smooth muscle cell apoptotic process • negative regulation of apoptotic process • negative regulation of muscle cell apoptotic process • apoptotic process • programmed cell death • phospholipase D-activating G protein-coupled receptor signaling pathway • positive regulation of hormone secretion • meiotic cell cycle process involved in oocyte maturation • sexual reproduction • cellular process involved in reproduction in multicellular organism • developmental process involved in reproduction • female gamete generation • meiotic cell cycle process • gamete generation • oocyte development • cell maturation • meiotic cell cycle • oogenesis • developmental maturation • anatomical structure maturation • germ cell development • oocyte maturation • oocyte differentiation • cell activation • leukocyte activation • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • renal filtration cell differentiation • kidney epithelium development • glomerular epithelial cell differentiation • epithelial cell differentiation • renal system development • nephron development • nephron epithelium development • epithelial cell differentiation involved in kidney development • glomerular epithelium development • glomerulus development • cell differentiation involved in kidney development • podocyte differentiation • kidney development • hexose transmembrane transport • carbohydrate transport • regulation of transmembrane transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • regulation of response to external stimulus • regulation of response to wounding • regulation of coagulation • regulation of response to stress • coagulation • response to wounding • regulation of hemostasis • wound healing • negative regulation of wound healing • regulation of blood coagulation • negative regulation of blood coagulation • hemostasis • negative regulation of response to wounding • blood coagulation • negative regulation of hemostasis • negative regulation of coagulation • negative regulation of response to external stimulus • regulation of wound healing • negative regulation of multicellular organismal process • regulation of vasoconstriction • intracellular calcium ion homeostasis • calcium ion homeostasis • cellular homeostasis • intracellular monoatomic cation homeostasis • intracellular chemical homeostasis • intracellular monoatomic ion homeostasis • sympathetic neuron axon guidance • axon guidance • neuron projection guidance • in utero embryonic development • body fluid secretion • negative regulation of protein metabolic process • positive regulation of JNK cascade • JNK cascade • regulation of JNK cascade • positive regulation of signaling receptor activity • regulation of signaling receptor activity • regulation of growth • regulation of cardiac muscle tissue growth • regulation of cell differentiation • muscle cell differentiation • muscle structure development • regulation of organ growth • regulation of heart growth • cardiac muscle tissue growth • muscle tissue development • cardiac cell development • positive regulation of developmental growth • positive regulation of heart growth • heart growth • positive regulation of organ growth • positive regulation of muscle cell differentiation • regulation of muscle cell differentiation • positive regulation of cardiac muscle tissue growth • positive regulation of cell growth involved in cardiac muscle cell development • striated muscle cell differentiation • cardiac muscle cell development • regulation of striated muscle cell differentiation • organ growth • striated muscle tissue development • striated muscle cell development • muscle cell development • positive regulation of cell differentiation • positive regulation of striated muscle cell differentiation • heart development • regulation of multicellular organismal development • regulation of developmental growth • cardiac muscle tissue development • physiological muscle hypertrophy • cardiac muscle cell differentiation • regulation of cell growth involved in cardiac muscle cell development • positive regulation of cell growth • regulation of cell growth • cardiocyte differentiation • cell growth involved in cardiac muscle cell development • positive regulation of growth • physiological cardiac muscle hypertrophy • cellular component biogenesis • cellular anatomical entity morphogenesis • cellular component assembly • sarcomere organization • actin filament-based process • actomyosin structure organization • positive regulation of cytoskeleton organization • positive regulation of supramolecular fiber organization • myofibril assembly • regulation of sarcomere organization • regulation of supramolecular fiber organization • supramolecular fiber organization • regulation of cytoskeleton organization • regulation of actin filament-based process • cellular component assembly involved in morphogenesis • membraneless organelle assembly • actin cytoskeleton organization • organelle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • positive regulation of sarcomere organization • cytoskeleton organization • response to leptin • positive regulation of DNA-templated transcription • positive regulation of macromolecule biosynthetic process • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • renal sodium ion transport • renal absorption • renal sodium ion absorption • sodium ion transport • semaphorin-plexin signaling pathway • semaphorin-plexin signaling pathway involved in neuron projection guidance • semaphorin-plexin signaling pathway involved in axon guidance • positive regulation of artery morphogenesis • regulation of artery morphogenesis • response to acid chemical • response to amino acid • cellular response to mineralocorticoid stimulus • response to mineralocorticoid • cellular response to corticosteroid stimulus • cellular response to lipid • cellular response to steroid hormone stimulus • positive regulation of cation transmembrane transport • regulation of transmembrane transporter activity • regulation of monoatomic ion transmembrane transport • regulation of transporter activity • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • positive regulation of monoatomic ion transmembrane transport • regulation of monoatomic ion transmembrane transporter activity • regulation of monoatomic ion transport • positive regulation of cation channel activity • regulation of cation channel activity • positive regulation of transporter activity • positive regulation of ion transmembrane transporter activity • regulation of monoatomic cation transmembrane transport • positive regulation of cytosolic calcium ion concentration • protein localization • cellular localization • regulation of protein localization • positive regulation of protein localization to nucleus • regulation of protein localization to nucleus • protein localization to nucleus • regulation of cellular localization • cellular macromolecule localization • protein localization to organelle • positive regulation of protein localization • endothelial cell migration • positive regulation of endothelial cell migration • regulation of endothelial cell migration • phosphatidylinositol 3-kinase/protein kinase B signal transduction • cellular response to growth factor stimulus • response to transforming growth factor beta • cellular response to transforming growth factor beta stimulus • response to growth factor • regulation of pH • icosanoid metabolic process • prostaglandin metabolic process • unsaturated fatty acid metabolic process • oxoacid metabolic process • lipid biosynthetic process • organic acid biosynthetic process • organic acid metabolic process • carboxylic acid biosynthetic process • prostanoid metabolic process • icosanoid biosynthetic process • small molecule metabolic process • prostaglandin biosynthetic process • prostanoid biosynthetic process • fatty acid metabolic process • monocarboxylic acid biosynthetic process • small molecule biosynthetic process • carboxylic acid metabolic process • fatty acid biosynthetic process • unsaturated fatty acid biosynthetic process • monocarboxylic acid metabolic process • lipid metabolic process • epithelial fluid transport • transepithelial transport • fluid transport • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • vascular associated smooth muscle cell proliferation • embryonic heart tube development • positive regulation of chemotaxis • positive regulation of neutrophil chemotaxis • taxis • regulation of immune system process • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • neutrophil migration • granulocyte migration • leukocyte migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • myeloid leukocyte migration • cell chemotaxis • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of chemotaxis • granulocyte chemotaxis • leukocyte chemotaxis • cellular response to oxidative stress • cellular response to chemical stress • cellular response to hydrogen peroxide • response to hydrogen peroxide • cellular response to reactive oxygen species • cAMP/PKA signal transduction • heart morphogenesis • cardiac neural crest cell development involved in heart development • neural crest cell development • mesenchymal cell migration • ameboidal-type cell migration • neural crest cell migration • stem cell development • cardiac neural crest cell development involved in outflow tract morphogenesis • cell migration involved in heart development • cardiac neural crest cell differentiation involved in heart development • outflow tract morphogenesis • cardiac neural crest cell migration involved in outflow tract morphogenesis • positive regulation of smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • positive regulation of prostaglandin-endoperoxide synthase activity • regulation of oxidoreductase activity • positive regulation of oxidoreductase activity • membrane depolarization • regulation of membrane potential • response to fatty acid • cellular response to fatty acid • endothelium development • kidney vasculature development • renal system vasculature development • glomerular endothelium development • glomerulus vasculature development • mitochondrion organization • response to nicotine • innervation • nerve development • axonogenesis involved in innervation • cellular response to glucocorticoid stimulus • response to mechanical stimulus • response to muscle stretch • membrane-enclosed lumen • intracellular organelle lumen • endoplasmic reticulum lumen • rough endoplasmic reticulum • rough endoplasmic reticulum lumen • organelle lumen • endoplasmic reticulum • cytoplasm • extracellular region • extracellular space • intracellular vesicle • cytoplasmic vesicle • Weibel-Palade body • secretory granule • clathrin-coated vesicle • secretory vesicle • coated vesicle • vesicle • transport vesicle • basal part of cell • D2 dopamine receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell division • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • microtubule cytoskeleton organization • regulation of mitotic spindle organization • microtubule cytoskeleton organization involved in mitosis • spindle organization • regulation of microtubule-based process • regulation of spindle organization • mitotic spindle organization • microtubule-based process • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to ketone • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P24530
Sequence	>8XWP_nogp_Chain_R P P C Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L Y I I Y K N K C M R N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A E D W P F G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S W S R I K G I G V P K W T A V E I V L I W V V S V V L A V P E A I G F D I I T M D Y K G S Y L R I C L L H P V Q K T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y N Q N D P N R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K N A F K S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZRT	A	Peptide	Endothelin	ET_B	Homo sapiens	ET-1	-	-	3.62	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWQ	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/β1/γ2	4.6	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWQ (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		4.6	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWP	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/β1/γ2	3.21	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWP (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		3.21	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XVH	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	chim(Gs-CtGq)/β1/γ2	3.26	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVH (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		3.26	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVE	A	Peptide	Endothelin	ET_B	Homo sapiens	BQ3020	-	chim(Gs-CtGq)/β1/γ2	3	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVE (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	BQ3020	-		3	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8IY6	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	3.13	2023-08-16	10.7554/eLife.85821
	8IY5	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/β1/γ2	2.8	2023-08-16	10.7554/eLife.85821
	8IY5 (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		2.8	2023-08-16	10.7554/eLife.85821
	8HCX	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.5	2023-03-22	10.1038/s41467-023-36998-9
	8HCX (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		3.5	2023-03-22	10.1038/s41467-023-36998-9
	8HBD	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-	Gi1/β1/γ2	2.99	2023-03-22	10.1038/s41467-023-36998-9
	8HBD (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-		2.99	2023-03-22	10.1038/s41467-023-36998-9
	6LRY	A	Peptide	Endothelin	ET_B	Homo sapiens	Sarafotoxin-B	-	-	3	2020-02-12	10.1016/j.bbrc.2019.12.091
	6K1Q	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL2500	-	-	2.7	2019-07-17	10.1038/s42003-019-0482-7
	6IGL	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-	-	2.7	2018-11-21	10.1038/s41467-018-07094-0
	6IGK	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-3	-	-	2	2018-11-21	10.1038/s41467-018-07094-0
	5XPR	A	Peptide	Endothelin	ET_B	Homo sapiens	Bosentan	-	-	3.6	2017-08-16	10.1038/nsmb.3450
	5X93	A	Peptide	Endothelin	ET_B	Homo sapiens	K-8794	-	-	2.2	2017-08-16	10.1038/nsmb.3450
	5GLI	A	Peptide	Endothelin	ET_B	Homo sapiens	-	-	-	2.5	2016-09-07	10.1038/nature19319
	5GLH	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	2.8	2016-09-07	10.1038/nature19319

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