psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D8	R:R:Q352	6.53	No	No	0	0	1
2	L:L:E9	L:L:V12	8.56	No	No	0	0	0
3	L:L:E10	L:L:Y13	5.61	No	Yes	2	0	0
4	L:L:E10	R:R:I94	4.1	No	No	2	0	4
5	L:L:V12	R:R:M245	6.09	No	Yes	0	0	1
6	L:L:H16	L:L:Y13	3.27	Yes	Yes	2	0	0
7	L:L:L17	L:L:Y13	4.69	Yes	Yes	2	0	0
8	L:L:Y13	R:R:I94	4.84	Yes	No	2	0	4
9	L:L:Y13	R:R:Y247	22.84	Yes	Yes	2	0	2
10	L:L:D18	L:L:F14	16.72	Yes	No	0	0	0
11	L:L:F14	R:R:K346	8.69	No	No	0	0	4
12	L:L:F14	R:R:L361	6.09	No	No	0	0	3
13	L:L:A15	R:R:L256	3.15	No	No	0	0	4
14	L:L:H16	L:L:L17	5.14	Yes	Yes	2	0	0
15	L:L:H16	R:R:D166	5.04	Yes	No	0	0	5
16	L:L:H16	R:R:L252	3.86	Yes	Yes	2	0	3
17	L:L:H16	R:R:I254	9.28	Yes	Yes	2	0	4
18	L:L:L17	R:R:I96	5.71	Yes	Yes	2	0	5
19	L:L:L17	R:R:L365	4.15	Yes	No	2	0	3
20	L:L:L17	R:R:Y369	3.52	Yes	Yes	2	0	3
21	L:L:D18	L:L:I19	5.6	Yes	No	1	0	0
22	L:L:D18	R:R:R343	4.76	Yes	No	0	0	6
23	L:L:D18	R:R:D368	6.65	Yes	No	1	0	4
24	L:L:I19	R:R:N158	8.5	No	Yes	1	0	7
25	L:L:I19	R:R:D368	4.2	No	No	1	0	4
26	L:L:I20	R:R:I157	2.94	Yes	No	1	0	6
27	L:L:I20	R:R:K161	7.27	Yes	No	1	0	5
28	L:L:I20	R:R:W167	5.87	Yes	Yes	1	0	9
29	L:L:I20	R:R:V177	3.07	Yes	No	1	0	5
30	L:L:I20	R:R:P178	5.08	Yes	Yes	1	0	5
31	L:L:W21	R:R:Q181	6.57	Yes	Yes	1	0	6
32	L:L:W21	R:R:K182	6.96	Yes	Yes	1	0	4
33	L:L:W21	R:R:L277	5.69	Yes	Yes	0	0	6
34	L:L:W21	R:R:W336	7.5	Yes	Yes	1	0	8
35	L:L:W21	R:R:L339	19.36	Yes	No	1	0	6
36	L:L:W21	R:R:H340	6.35	Yes	Yes	1	0	8
37	L:L:W21	R:R:R343	18.99	Yes	No	0	0	6
38	R:R:C358	R:R:C90	7.28	No	No	2	8	7
39	R:R:G92	R:R:P93	4.06	No	No	0	4	4
40	R:R:C358	R:R:I94	3.27	No	No	2	8	4
41	R:R:I96	R:R:L162	5.71	Yes	No	2	5	4
42	R:R:I96	R:R:L365	2.85	Yes	No	2	5	3
43	R:R:I96	R:R:Y369	8.46	Yes	Yes	2	5	3
44	R:R:E98	R:R:K101	12.15	No	No	2	3	6
45	R:R:E98	R:R:Y102	13.47	No	No	2	3	3
46	R:R:F100	R:R:T99	5.19	No	No	0	4	5
47	R:R:K101	R:R:Y102	13.14	No	No	2	6	3
48	R:R:K101	R:R:L162	7.05	No	No	2	6	4
49	R:R:N104	R:R:Y369	4.65	No	Yes	0	5	3
50	R:R:N104	R:R:N373	6.81	No	Yes	0	5	5
51	R:R:T105	R:R:V159	3.17	No	No	0	6	7
52	R:R:N373	R:R:V107	2.96	Yes	No	0	5	5
53	R:R:I155	R:R:S108	3.1	Yes	No	1	7	7
54	R:R:S108	R:R:V159	3.23	No	No	0	7	7
55	R:R:N373	R:R:S108	5.96	Yes	No	1	5	7
56	R:R:S376	R:R:V111	6.46	No	No	0	7	8
57	R:R:F112	R:R:I116	3.77	No	No	0	7	7
58	R:R:F112	R:R:I155	3.77	No	Yes	1	7	7
59	R:R:F112	R:R:P156	4.33	No	No	1	7	9
60	R:R:C380	R:R:L114	6.35	No	No	0	8	5
61	R:R:D147	R:R:N119	5.39	Yes	No	0	9	9
62	R:R:L148	R:R:N119	5.49	No	No	0	7	9
63	R:R:I125	R:R:L122	2.85	No	Yes	0	7	9
64	R:R:A144	R:R:L122	3.15	No	Yes	0	9	9
65	R:R:F393	R:R:L122	3.65	Yes	Yes	0	9	9
66	R:R:R124	R:R:Y127	9.26	No	No	0	3	2
67	R:R:C396	R:R:I125	4.91	No	No	0	4	7
68	R:R:A141	R:R:I126	3.25	No	No	0	7	7
69	R:R:K128	R:R:N129	11.19	No	No	0	4	6
70	R:R:M132	R:R:N129	5.61	Yes	No	0	7	6
71	R:R:M132	R:R:N137	4.21	Yes	No	0	7	8
72	R:R:C396	R:R:M132	4.86	No	Yes	0	4	7
73	R:R:N134	R:R:P136	6.52	No	No	0	8	8
74	R:R:N134	R:R:N137	10.9	No	No	0	8	8
75	R:R:G135	R:R:P136	4.06	No	No	0	7	8
76	R:R:G135	R:R:P215	4.06	No	No	4	7	1
77	R:R:G135	R:R:T218	3.64	No	No	4	7	7
78	R:R:A194	R:R:L139	4.73	No	No	0	7	7
79	R:R:L139	R:R:L195	8.3	No	No	0	7	9
80	R:R:D198	R:R:L139	5.43	No	No	0	8	7
81	R:R:I140	R:R:L195	5.71	No	No	0	8	9
82	R:R:I222	R:R:S142	3.1	No	No	0	7	9
83	R:R:D147	R:R:L143	6.79	Yes	Yes	0	9	9
84	R:R:L143	R:R:S191	7.51	Yes	No	0	9	8
85	R:R:L143	R:R:L192	4.15	Yes	No	0	9	8
86	R:R:L143	R:R:N382	6.87	Yes	No	0	9	9
87	R:R:L145	R:R:L148	4.15	No	No	0	6	7
88	R:R:D147	R:R:T188	2.89	Yes	No	0	9	9
89	R:R:D147	R:R:S379	5.89	Yes	No	0	9	9
90	R:R:L149	R:R:S184	4.5	No	No	0	7	8
91	R:R:D154	R:R:H150	8.82	Yes	Yes	1	6	8
92	R:R:H150	R:R:Q181	3.71	Yes	Yes	1	8	6
93	R:R:H150	R:R:S184	5.58	Yes	No	1	8	8
94	R:R:H150	R:R:V185	5.54	Yes	No	1	8	7
95	R:R:H150	R:R:W336	4.23	Yes	Yes	1	8	8
96	R:R:I151	R:R:I155	4.42	No	Yes	0	6	7
97	R:R:I151	R:R:S376	3.1	No	No	0	6	7
98	R:R:I153	R:R:I180	5.89	No	No	0	5	5
99	R:R:D154	R:R:N158	9.42	Yes	Yes	1	6	7
100	R:R:D154	R:R:Q181	14.36	Yes	Yes	1	6	6
101	R:R:D154	R:R:I372	8.4	Yes	No	1	6	6
102	R:R:I155	R:R:P156	5.08	Yes	No	1	7	9
103	R:R:I155	R:R:N158	2.83	Yes	Yes	1	7	7
104	R:R:I155	R:R:N373	2.83	Yes	Yes	1	7	5
105	R:R:I157	R:R:N158	4.25	No	Yes	1	6	7
106	R:R:I157	R:R:V177	3.07	No	No	1	6	5
107	R:R:I372	R:R:N158	8.5	No	Yes	1	6	7
108	R:R:K161	R:R:W167	9.28	No	Yes	1	5	9
109	R:R:L162	R:R:Y369	14.07	No	Yes	2	4	3
110	R:R:D166	R:R:P168	8.05	No	No	0	5	2
111	R:R:C174	R:R:W167	6.53	No	Yes	1	9	9
112	R:R:C255	R:R:W167	10.45	No	Yes	1	9	9
113	R:R:F169	R:R:G170	3.01	No	No	0	7	8
114	R:R:F169	R:R:M173	6.22	No	No	0	7	6
115	R:R:C174	R:R:I242	3.27	No	No	0	9	5
116	R:R:C174	R:R:C255	7.28	No	No	1	9	9
117	R:R:I238	R:R:K175	4.36	No	No	0	5	7
118	R:R:D241	R:R:K175	6.91	No	No	0	4	7
119	R:R:I180	R:R:L176	4.28	No	No	0	5	5
120	R:R:P178	R:R:V177	5.3	Yes	No	1	5	5
121	R:R:K182	R:R:P178	3.35	Yes	Yes	1	4	5
122	R:R:F240	R:R:P178	5.78	No	Yes	1	5	5
123	R:R:F179	R:R:I180	3.77	Yes	No	0	6	5
124	R:R:A233	R:R:F179	5.55	No	Yes	0	7	6
125	R:R:K182	R:R:Q181	8.14	Yes	Yes	1	4	6
126	R:R:Q181	R:R:S184	2.89	Yes	No	1	6	8
127	R:R:E236	R:R:K182	9.45	Yes	Yes	1	5	4
128	R:R:V185	R:R:Y281	3.79	No	Yes	0	7	6
129	R:R:V185	R:R:W336	7.36	No	Yes	1	7	8
130	R:R:G186	R:R:S229	3.71	No	No	0	6	8
131	R:R:I187	R:R:W226	8.22	No	No	0	7	9
132	R:R:I187	R:R:S229	4.64	No	No	0	7	8
133	R:R:V189	R:R:Y281	3.79	No	Yes	0	8	6
134	R:R:P285	R:R:V189	3.53	Yes	No	0	9	8
135	R:R:F280	R:R:L190	3.65	Yes	No	0	5	6
136	R:R:C193	R:R:P285	3.77	No	Yes	5	8	9
137	R:R:C193	R:R:I288	6.55	No	No	0	8	7
138	R:R:C193	R:R:T289	3.38	No	Yes	5	8	8
139	R:R:L195	R:R:R199	6.07	No	No	0	9	9
140	R:R:S196	R:R:T289	3.2	No	Yes	0	9	8
141	R:R:S196	R:R:Y293	11.45	No	Yes	0	9	9
142	R:R:I197	R:R:W217	4.7	No	No	0	6	5
143	R:R:F292	R:R:I197	3.77	No	No	0	7	6
144	R:R:D198	R:R:W217	5.58	No	No	0	8	5
145	R:R:D198	R:R:T218	4.34	No	No	0	8	7
146	R:R:R199	R:R:Y293	9.26	No	Yes	0	9	9
147	R:R:M296	R:R:R199	3.72	No	No	0	8	9
148	R:R:F292	R:R:Y200	8.25	No	No	0	7	8
149	R:R:L295	R:R:Y200	10.55	No	No	0	3	8
150	R:R:E299	R:R:Y200	11.22	No	No	0	5	8
151	R:R:R201	R:R:S205	9.22	No	No	0	5	7
152	R:R:R201	R:R:R208	6.4	No	No	0	5	5
153	R:R:M296	R:R:V203	4.56	No	No	3	8	9
154	R:R:M300	R:R:V203	6.09	Yes	No	3	8	9
155	R:R:A204	R:R:E299	3.02	No	No	0	7	5
156	R:R:S207	R:R:W206	7.41	No	No	0	5	8
157	R:R:P215	R:R:V214	3.53	No	No	0	1	6
158	R:R:P215	R:R:T218	15.74	No	No	4	1	7
159	R:R:A219	R:R:K216	3.21	No	No	0	3	3
160	R:R:K216	R:R:V220	6.07	No	No	0	3	3
161	R:R:E221	R:R:W217	31.62	No	No	0	6	5
162	R:R:E221	R:R:I225	4.1	No	No	0	6	7
163	R:R:L224	R:R:V228	2.98	No	No	0	3	4
164	R:R:L232	R:R:V228	2.98	No	No	0	5	4
165	R:R:L232	R:R:W276	9.11	No	Yes	1	5	4
166	R:R:F280	R:R:L232	4.87	Yes	No	1	5	5
167	R:R:P235	R:R:V234	3.53	No	No	0	8	4
168	R:R:F265	R:R:P235	2.89	No	No	0	3	8
169	R:R:P235	R:R:Y269	18.08	No	Yes	0	8	3
170	R:R:E236	R:R:F240	8.16	Yes	No	1	5	5
171	R:R:E236	R:R:L257	5.3	Yes	Yes	1	5	5
172	R:R:E236	R:R:Y269	11.22	Yes	Yes	1	5	3
173	R:R:E236	R:R:K273	8.1	Yes	Yes	1	5	7
174	R:R:I238	R:R:M266	2.92	No	Yes	0	5	4
175	R:R:F240	R:R:L257	6.09	No	Yes	1	5	5
176	R:R:D241	R:R:H258	12.61	No	No	0	4	4
177	R:R:I242	R:R:R253	7.52	No	No	0	5	5
178	R:R:I243	R:R:L256	2.85	No	No	0	1	4
179	R:R:T244	R:R:Y251	16.23	No	No	0	1	5
180	R:R:R253	R:R:T244	3.88	No	No	0	5	1
181	R:R:M245	R:R:Y247	5.99	Yes	Yes	2	1	2
182	R:R:L252	R:R:M245	4.24	Yes	Yes	2	3	1
183	R:R:I254	R:R:M245	2.92	Yes	Yes	2	4	1
184	R:R:K248	R:R:Y247	14.33	No	Yes	0	1	2
185	R:R:L252	R:R:Y247	3.52	Yes	Yes	2	3	2
186	R:R:I254	R:R:L252	2.85	Yes	Yes	2	4	3
187	R:R:I254	R:R:L256	2.85	Yes	No	0	4	4
188	R:R:K273	R:R:L257	5.64	Yes	Yes	1	7	5
189	R:R:H258	R:R:P259	3.05	No	No	0	4	6
190	R:R:H258	R:R:Q261	9.89	No	No	0	4	2
191	R:R:M266	R:R:Q261	10.88	Yes	No	0	4	2
192	R:R:M266	R:R:T263	7.53	Yes	No	0	4	3
193	R:R:F268	R:R:T271	3.89	No	No	0	1	4
194	R:R:A272	R:R:F268	4.16	No	No	0	4	1
195	R:R:K273	R:R:Y269	8.36	Yes	Yes	1	7	3
196	R:R:W276	R:R:Y269	7.72	Yes	Yes	1	4	3
197	R:R:K273	R:R:L277	8.46	Yes	Yes	0	7	6
198	R:R:D274	R:R:W275	29.03	No	No	0	5	5
199	R:R:D274	R:R:I344	4.2	No	No	0	5	6
200	R:R:D274	R:R:L347	16.29	No	No	0	5	5
201	R:R:L277	R:R:W276	3.42	Yes	Yes	0	6	4
202	R:R:F280	R:R:W276	11.02	Yes	Yes	1	5	4
203	R:R:L277	R:R:Y281	4.69	Yes	Yes	0	6	6
204	R:R:F278	R:R:F282	9.65	No	Yes	1	6	8
205	R:R:C283	R:R:F278	4.19	No	No	0	5	6
206	R:R:F278	R:R:H340	3.39	No	Yes	1	6	8
207	R:R:F280	R:R:Y281	8.25	Yes	Yes	0	5	6
208	R:R:F280	R:R:L284	3.65	Yes	No	0	5	6
209	R:R:F282	R:R:L337	3.65	Yes	No	0	8	5
210	R:R:F282	R:R:H340	10.18	Yes	Yes	1	8	8
211	R:R:L284	R:R:P285	3.28	No	Yes	0	6	9
212	R:R:I288	R:R:L284	2.85	No	No	0	7	6
213	R:R:P285	R:R:T289	3.5	Yes	Yes	5	9	8
214	R:R:F332	R:R:P285	5.78	No	Yes	0	9	9
215	R:R:T289	R:R:V329	3.17	Yes	No	0	8	8
216	R:R:F291	R:R:F292	6.43	No	No	0	4	7
217	R:R:F291	R:R:L295	12.18	No	No	0	4	3
218	R:R:V325	R:R:Y293	8.83	No	Yes	0	8	9
219	R:R:M296	R:R:M300	4.33	No	Yes	3	8	8
220	R:R:L301	R:R:M300	4.24	No	Yes	3	5	8
221	R:R:M300	R:R:R318	6.2	Yes	No	3	8	7
222	R:R:M300	R:R:V321	4.56	Yes	No	0	8	8
223	R:R:L301	R:R:R318	3.64	No	No	3	5	7
224	R:R:H314	R:R:L311	5.14	No	No	0	4	4
225	R:R:D313	R:R:N312	5.39	No	No	0	3	2
226	R:R:D313	R:R:H314	10.08	No	No	0	3	4
227	R:R:D313	R:R:Q317	3.92	No	No	0	3	5
228	R:R:K316	R:R:R319	24.75	No	No	0	4	5
229	R:R:E320	R:R:K316	10.8	No	No	0	7	4
230	R:R:T324	R:R:V389	6.35	No	No	0	8	7
231	R:R:I381	R:R:V331	7.68	No	No	0	6	6
232	R:R:F332	R:R:N378	9.67	No	No	0	9	9
233	R:R:C335	R:R:L377	3.17	No	No	0	8	6
234	R:R:C335	R:R:N378	6.3	No	No	0	8	9
235	R:R:L339	R:R:W336	7.97	No	Yes	1	6	8
236	R:R:H340	R:R:W336	7.41	Yes	Yes	1	8	8
237	R:R:A375	R:R:W336	10.37	No	Yes	0	8	8
238	R:R:N378	R:R:W336	7.91	No	Yes	0	9	8
239	R:R:M374	R:R:P338	3.35	No	No	0	7	9
240	R:R:I372	R:R:L339	2.85	No	No	1	6	6
241	R:R:L341	R:R:L345	4.15	No	Yes	0	6	5
242	R:R:L367	R:R:S342	7.51	No	No	0	5	5
243	R:R:D368	R:R:S342	10.31	No	No	0	4	5
244	R:R:I344	R:R:T348	3.04	No	No	0	6	4
245	R:R:L345	R:R:T348	2.95	Yes	No	6	5	4
246	R:R:L345	R:R:L349	4.15	Yes	No	6	5	3
247	R:R:L345	R:R:L364	8.3	Yes	No	0	5	3
248	R:R:K346	R:R:L347	4.23	No	No	0	4	5
249	R:R:L349	R:R:T348	2.95	No	No	6	3	4
250	R:R:R357	R:R:Y350	15.43	No	No	0	5	2
251	R:R:N351	R:R:N353	10.9	No	No	7	1	1
252	R:R:D354	R:R:N351	14.81	Yes	No	7	1	1
253	R:R:Q352	R:R:R357	16.35	No	No	0	1	5
254	R:R:D354	R:R:N353	5.39	Yes	No	7	1	1
255	R:R:D354	R:R:P355	3.22	Yes	No	0	1	1
256	R:R:D354	R:R:N356	5.39	Yes	No	0	1	3
257	R:R:E359	R:R:N356	3.94	No	No	0	4	3
258	R:R:F363	R:R:L367	7.31	No	No	0	3	5
259	R:R:L365	R:R:Y369	8.21	No	Yes	2	3	3
260	R:R:L377	R:R:M374	2.83	No	No	0	6	7
261	R:R:I381	R:R:L377	5.71	No	No	0	6	6
262	R:R:F393	R:R:L386	8.53	Yes	No	0	9	9
263	R:R:F393	R:R:S390	6.61	Yes	No	0	9	8
264	R:R:F393	R:R:F397	4.29	Yes	No	0	9	7
265	R:R:K394	R:R:K398	2.87	No	No	0	8	4
266	R:R:K398	R:R:N395	4.2	No	No	0	4	4
267	R:R:A183	R:R:F179	2.77	No	Yes	0	6	6
268	R:R:L330	R:R:L334	2.77	No	No	0	5	5
269	R:R:L328	R:R:N382	2.75	No	No	0	8	9
270	R:R:I153	R:R:Q181	2.74	No	Yes	0	5	6
271	R:R:E165	R:R:I96	2.73	No	Yes	0	4	5
272	R:R:R133	R:R:V214	2.62	No	No	0	7	6
273	R:R:F179	R:R:V230	2.62	Yes	No	0	6	3
274	R:R:F326	R:R:T294	2.59	No	No	0	5	4
275	R:R:F326	R:R:T297	2.59	No	No	0	5	5
276	R:R:I138	R:R:R133	2.51	No	No	0	6	7
277	R:R:F100	R:R:K97	2.48	No	No	0	4	3
278	R:R:S142	R:R:W226	2.47	No	No	0	9	9
279	R:R:F282	R:R:L286	2.44	Yes	No	0	8	7
280	R:R:F332	R:R:L286	2.44	No	No	0	9	7
281	R:R:L361	R:R:Y350	2.34	No	No	0	3	2
282	R:R:L145	R:R:W226	2.28	No	No	0	6	9
283	R:R:F326	R:R:Y293	2.06	No	Yes	0	5	9
284	R:R:G118	R:R:P383	2.03	No	No	0	8	9
285	R:R:G371	R:R:P338	2.03	No	No	0	7	9
286	R:R:C90	R:R:G92	1.96	No	No	2	7	4
287	R:R:C358	R:R:G92	1.96	No	No	2	8	4
288	R:R:C380	R:R:G115	1.96	No	No	0	8	8
289	R:R:G118	R:R:T121	1.82	No	No	0	8	6
290	R:R:G118	R:R:I117	1.76	No	No	0	8	5
291	R:R:G146	R:R:I187	1.76	No	No	0	8	7
292	R:R:G213	R:R:I212	1.76	No	No	0	6	3
293	R:R:G371	R:R:I370	1.76	No	No	0	7	5
294	R:R:G239	R:R:M266	1.75	No	Yes	0	5	4
295	R:R:C283	R:R:S279	1.72	No	No	0	5	4
296	R:R:C109	R:R:V113	1.71	No	No	0	4	5
297	R:R:C380	R:R:V111	1.71	No	No	0	8	8
298	R:R:G146	R:R:L149	1.71	No	No	0	8	7
299	R:R:G239	R:R:L257	1.71	No	Yes	0	5	5
300	R:R:C327	R:R:V331	1.71	No	No	0	5	6
301	R:R:A290	R:R:V329	1.7	No	No	0	5	8
302	R:R:I384	R:R:P383	1.69	No	No	0	7	9
303	R:R:D246	R:R:G249	1.68	No	No	0	1	3
304	R:R:A322	R:R:T297	1.68	No	No	0	7	5
305	R:R:L122	R:R:P383	1.64	Yes	No	0	9	9
306	R:R:C131	R:R:M132	1.62	No	Yes	0	5	7
307	R:R:A171	R:R:I242	1.62	No	No	0	3	5
308	R:R:A237	R:R:I238	1.62	No	No	0	4	5
309	R:R:C327	R:R:K323	1.62	No	No	0	5	5
310	R:R:S390	R:R:V389	1.62	No	No	0	8	7
311	R:R:V227	R:R:V228	1.6	No	No	0	4	4
312	R:R:T105	R:R:V106	1.59	No	No	0	6	6
313	R:R:A141	R:R:L123	1.58	No	No	0	7	7
314	R:R:A144	R:R:L123	1.58	No	No	0	9	7
315	R:R:A164	R:R:L163	1.58	No	No	0	5	4
316	R:R:A333	R:R:L286	1.58	No	No	0	6	7
317	R:R:A385	R:R:L328	1.58	No	No	0	7	8
318	R:R:I116	R:R:S120	1.55	No	No	0	7	4
319	R:R:I222	R:R:V223	1.54	No	No	0	7	3
320	R:R:K97	R:R:S362	1.53	No	No	0	3	3
321	R:R:A264	R:R:Q267	1.52	No	No	0	4	1
322	R:R:L252	R:R:S250	1.5	Yes	No	0	3	1
323	R:R:K270	R:R:T271	1.5	No	No	0	4	4
324	R:R:L149	R:R:V152	1.49	No	No	0	7	5
325	R:R:L163	R:R:V159	1.49	No	No	0	4	7
326	R:R:L388	R:R:V389	1.49	No	No	0	6	7
327	R:R:K391	R:R:K394	1.44	No	No	0	5	8
328	R:R:P168	R:R:Y160	1.39	No	No	0	2	4
329	R:R:L311	R:R:L315	1.38	No	No	0	4	4
330	R:R:L349	R:R:L360	1.38	No	No	0	3	2
331	R:R:L360	R:R:N356	1.37	No	No	0	2	3
332	L:L:A11	R:R:Y350	1.33	No	No	0	0	2
333	R:R:R392	R:R:S390	1.32	No	No	0	6	8
334	R:R:F363	R:R:V366	1.31	No	No	0	3	1
335	R:R:A272	R:R:W275	1.3	No	No	0	4	5
336	R:R:Q261	R:R:Q267	1.28	No	No	0	2	1
337	R:R:K128	R:R:R124	1.24	No	No	0	4	3
338	R:R:K130	R:R:R133	1.24	No	No	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y13	8.25	5	2	0
2	L:L:H16	5.318	5	2	0
3	L:L:L17	4.642	5	2	0
4	L:L:D18	8.4325	4	1	0
5	L:L:I20	4.846	5	1	0
6	L:L:W21	10.2029	7	1	0
7	R:R:I96	5.092	5	2	5
8	R:R:L122	2.8225	4	0	9
9	R:R:M132	4.075	4	0	7
10	R:R:L143	6.33	4	0	9
11	R:R:D147	5.24	4	0	9
12	R:R:H150	5.576	5	1	8
13	R:R:D154	10.25	4	1	6
14	R:R:I155	3.67167	6	1	7
15	R:R:N158	6.7	5	1	7
16	R:R:W167	8.0325	4	1	9
17	R:R:P178	4.8775	4	1	5
18	R:R:F179	3.6775	4	0	6
19	R:R:Q181	6.40167	6	1	6
20	R:R:K182	6.975	4	1	4
21	R:R:E236	8.446	5	1	5
22	R:R:M245	4.81	4	2	1
23	R:R:Y247	11.67	4	2	2
24	R:R:L252	3.194	5	2	3
25	R:R:I254	4.475	4	2	4
26	R:R:L257	4.685	4	1	5
27	R:R:M266	5.77	4	0	4
28	R:R:Y269	11.345	4	1	3
29	R:R:K273	7.64	4	1	7
30	R:R:W276	7.8175	4	1	4
31	R:R:L277	5.565	4	0	6
32	R:R:F280	6.288	5	1	5
33	R:R:Y281	5.13	4	0	6
34	R:R:F282	6.48	4	1	8
35	R:R:P285	3.972	5	5	9
36	R:R:T289	3.3125	4	5	8
37	R:R:Y293	7.9	4	0	9
38	R:R:M300	5.084	5	3	8
39	R:R:W336	7.53571	7	1	8
40	R:R:H340	6.8325	4	1	8
41	R:R:L345	4.8875	4	6	5
42	R:R:D354	7.2025	4	7	1
43	R:R:Y369	7.782	5	2	3
44	R:R:N373	4.64	4	1	5
45	R:R:F393	5.77	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D18	L:L:F14	32.9155	16.72	Yes	No	0	0	0
2	L:L:I19	R:R:N158	11.1431	8.5	No	Yes	1	0	7
3	R:R:I155	R:R:N158	90.5688	2.83	Yes	Yes	1	7	7
4	R:R:I155	R:R:N373	64.7059	2.83	Yes	Yes	1	7	5
5	R:R:N104	R:R:N373	62.4627	6.81	No	Yes	0	5	5
6	R:R:N104	R:R:Y369	60.914	4.65	No	Yes	0	5	3
7	L:L:L17	R:R:Y369	48.2256	3.52	Yes	Yes	2	0	3
8	L:L:L17	L:L:Y13	20.3695	4.69	Yes	Yes	2	0	0
9	L:L:V12	R:R:M245	10.3653	6.09	No	Yes	0	0	1
10	L:L:H16	L:L:L17	26.9984	5.14	Yes	Yes	2	0	0
11	L:L:H16	R:R:I254	11.8828	9.28	Yes	Yes	2	0	4
12	L:L:F14	R:R:K346	25.2934	8.69	No	No	0	0	4
13	L:L:D18	R:R:R343	31.6515	4.76	Yes	No	0	0	6
14	R:R:I157	R:R:N158	11.7647	4.25	No	Yes	1	6	7
15	L:L:W21	R:R:R343	32.2696	18.99	Yes	No	0	0	6
16	L:L:W21	R:R:K182	12.7717	6.96	Yes	Yes	1	0	4
17	R:R:K182	R:R:P178	10.0389	3.35	Yes	Yes	1	4	5
18	L:L:W21	R:R:Q181	13.6572	6.57	Yes	Yes	1	0	6
19	L:L:W21	R:R:L277	26.2865	5.69	Yes	Yes	0	0	6
20	L:L:W21	R:R:W336	19.4736	7.5	Yes	Yes	1	0	8
21	R:R:I151	R:R:I155	10.7264	4.42	No	Yes	0	6	7
22	R:R:Q181	R:R:S184	12.9349	2.89	Yes	No	1	6	8
23	R:R:L149	R:R:S184	31.2418	4.5	No	No	0	7	8
24	R:R:G146	R:R:L149	28.5402	1.71	No	No	0	8	7
25	R:R:G146	R:R:I187	27.179	1.76	No	No	0	8	7
26	R:R:I187	R:R:W226	23.0537	8.22	No	No	0	7	9
27	R:R:L145	R:R:W226	17.4561	2.28	No	No	0	6	9
28	R:R:L145	R:R:L148	16.0393	4.15	No	No	0	6	7
29	R:R:L148	R:R:N119	14.6156	5.49	No	No	0	7	9
30	R:R:D147	R:R:N119	13.1849	5.39	Yes	No	0	9	9
31	R:R:L277	R:R:Y281	20.5813	4.69	Yes	Yes	0	6	6
32	R:R:V189	R:R:Y281	42.6002	3.79	No	Yes	0	8	6
33	R:R:P285	R:R:V189	42.2043	3.53	Yes	No	0	9	8
34	R:R:P285	R:R:T289	100	3.5	Yes	Yes	5	9	8
35	R:R:S196	R:R:T289	96.7289	3.2	No	Yes	0	9	8
36	R:R:S196	R:R:Y293	95.465	11.45	No	Yes	0	9	9
37	R:R:R199	R:R:Y293	87.9575	9.26	No	Yes	0	9	9
38	R:R:L195	R:R:R199	78.9013	6.07	No	No	0	9	9
39	R:R:L139	R:R:L195	76.3664	8.3	No	No	0	7	9
40	R:R:D198	R:R:L139	73.776	5.43	No	No	0	8	7
41	R:R:D198	R:R:T218	56.8269	4.34	No	No	0	8	7
42	R:R:G135	R:R:T218	47.5589	3.64	No	No	4	7	7
43	R:R:G135	R:R:P136	46.5657	4.06	No	No	0	7	8
44	R:R:N134	R:R:P136	45.0448	6.52	No	No	0	8	8
45	R:R:N134	R:R:N137	43.5169	10.9	No	No	0	8	8
46	R:R:M132	R:R:N137	41.9821	4.21	Yes	No	0	7	8
47	R:R:C396	R:R:M132	32.6238	4.86	No	Yes	0	4	7
48	R:R:C396	R:R:I125	31.2209	4.91	No	No	0	4	7
49	R:R:N378	R:R:W336	64.9246	7.91	No	Yes	0	9	8
50	R:R:F332	R:R:N378	57.5526	9.67	No	No	0	9	9
51	R:R:F332	R:R:P285	58.0006	5.78	No	Yes	0	9	9
52	R:R:I125	R:R:L122	29.634	2.85	No	Yes	0	7	9
53	R:R:F393	R:R:L122	13.3447	3.65	Yes	Yes	0	9	9
54	R:R:D154	R:R:N158	56.6706	9.42	Yes	Yes	1	6	7
55	R:R:D154	R:R:H150	42.6245	8.82	Yes	Yes	1	6	8
56	R:R:H150	R:R:W336	30.2208	4.23	Yes	Yes	1	8	8
57	R:R:I153	R:R:Q181	12.3446	2.74	No	Yes	0	5	6
58	R:R:I153	R:R:I180	10.6014	5.89	No	No	0	5	5
59	R:R:I372	R:R:N158	23.3975	8.5	No	Yes	1	6	7
60	R:R:E236	R:R:K182	11.4834	9.45	Yes	Yes	1	5	4
61	R:R:G239	R:R:L257	21.0779	1.71	No	Yes	0	5	5
62	R:R:G239	R:R:M266	19.4979	1.75	No	Yes	0	5	4
63	R:R:D198	R:R:W217	18.2929	5.58	No	No	0	8	5
64	R:R:I197	R:R:W217	13.5218	4.7	No	No	0	6	5
65	R:R:F292	R:R:I197	11.8585	3.77	No	No	0	7	6
66	R:R:K346	R:R:L347	24.1961	4.23	No	No	0	4	5
67	R:R:D274	R:R:L347	23.0433	16.29	No	No	0	5	5
68	R:R:D274	R:R:I344	16.0289	4.2	No	No	0	5	6
69	R:R:C335	R:R:N378	12.7057	6.3	No	No	0	8	9
70	R:R:C335	R:R:L377	11.4661	3.17	No	No	0	8	6
71	R:R:I344	R:R:T348	14.8274	3.04	No	No	0	6	4
72	L:L:I20	R:R:P178	12.3342	5.08	Yes	Yes	1	0	5
73	R:R:D154	R:R:Q181	14.9212	14.36	Yes	Yes	1	6	6
74	R:R:I372	R:R:L339	23.6405	2.85	No	No	1	6	6
75	R:R:L339	R:R:W336	20.2931	7.97	No	Yes	1	6	8
76	R:R:H150	R:R:S184	19.6437	5.58	Yes	No	1	8	8
77	R:R:H150	R:R:V185	26.2275	5.54	Yes	No	1	8	7
78	R:R:V185	R:R:Y281	26.6477	3.79	No	Yes	0	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:D8	R:R:Q352	6.53	0	No	No	0	1	0	1
L:L:E10	R:R:I94	4.1	2	No	No	0	4	0	1
L:L:V12	R:R:M245	6.09	0	No	Yes	0	1	0	1
L:L:Y13	R:R:I94	4.84	2	Yes	No	0	4	0	1
L:L:Y13	R:R:Y247	22.84	2	Yes	Yes	0	2	0	1
L:L:F14	R:R:K346	8.69	0	No	No	0	4	0	1
L:L:F14	R:R:L361	6.09	0	No	No	0	3	0	1
L:L:A15	R:R:L256	3.15	0	No	No	0	4	0	1
L:L:H16	R:R:D166	5.04	2	Yes	No	0	5	0	1
L:L:H16	R:R:L252	3.86	2	Yes	Yes	0	3	0	1
L:L:H16	R:R:I254	9.28	2	Yes	Yes	0	4	0	1
L:L:L17	R:R:I96	5.71	2	Yes	Yes	0	5	0	1
L:L:L17	R:R:L365	4.15	2	Yes	No	0	3	0	1
L:L:L17	R:R:Y369	3.52	2	Yes	Yes	0	3	0	1
L:L:D18	R:R:R343	4.76	1	Yes	No	0	6	0	1
L:L:D18	R:R:D368	6.65	1	Yes	No	0	4	0	1
L:L:I19	R:R:N158	8.5	1	No	Yes	0	7	0	1
L:L:I19	R:R:D368	4.2	1	No	No	0	4	0	1
L:L:I20	R:R:I157	2.94	1	Yes	No	0	6	0	1
L:L:I20	R:R:K161	7.27	1	Yes	No	0	5	0	1
L:L:I20	R:R:W167	5.87	1	Yes	Yes	0	9	0	1
L:L:I20	R:R:V177	3.07	1	Yes	No	0	5	0	1
L:L:I20	R:R:P178	5.08	1	Yes	Yes	0	5	0	1
L:L:W21	R:R:Q181	6.57	1	Yes	Yes	0	6	0	1
L:L:W21	R:R:K182	6.96	1	Yes	Yes	0	4	0	1
L:L:W21	R:R:L277	5.69	1	Yes	Yes	0	6	0	1
L:L:W21	R:R:W336	7.5	1	Yes	Yes	0	8	0	1
L:L:W21	R:R:L339	19.36	1	Yes	No	0	6	0	1
L:L:W21	R:R:H340	6.35	1	Yes	Yes	0	8	0	1
L:L:W21	R:R:R343	18.99	1	Yes	No	0	6	0	1
R:R:C358	R:R:I94	3.27	2	No	No	8	4	2	1
R:R:I96	R:R:L162	5.71	2	Yes	No	5	4	1	2
R:R:I96	R:R:L365	2.85	2	Yes	No	5	3	1	1
R:R:I96	R:R:Y369	8.46	2	Yes	Yes	5	3	1	1
R:R:N104	R:R:Y369	4.65	0	No	Yes	5	3	2	1
R:R:D154	R:R:H150	8.82	1	Yes	Yes	6	8	2	2
R:R:H150	R:R:Q181	3.71	1	Yes	Yes	8	6	2	1
R:R:H150	R:R:S184	5.58	1	Yes	No	8	8	2	2
R:R:H150	R:R:V185	5.54	1	Yes	No	8	7	2	2
R:R:H150	R:R:W336	4.23	1	Yes	Yes	8	8	2	1
R:R:D154	R:R:N158	9.42	1	Yes	Yes	6	7	2	1
R:R:D154	R:R:Q181	14.36	1	Yes	Yes	6	6	2	1
R:R:D154	R:R:I372	8.4	1	Yes	No	6	6	2	2
R:R:I155	R:R:N158	2.83	1	Yes	Yes	7	7	2	1
R:R:I157	R:R:N158	4.25	1	No	Yes	6	7	1	1
R:R:I157	R:R:V177	3.07	1	No	No	6	5	1	1
R:R:I372	R:R:N158	8.5	1	No	Yes	6	7	2	1
R:R:K161	R:R:W167	9.28	1	No	Yes	5	9	1	1
R:R:L162	R:R:Y369	14.07	2	No	Yes	4	3	2	1
R:R:D166	R:R:P168	8.05	0	No	No	5	2	1	2
R:R:C174	R:R:W167	6.53	1	No	Yes	9	9	2	1
R:R:C255	R:R:W167	10.45	1	No	Yes	9	9	2	1
R:R:C174	R:R:C255	7.28	1	No	No	9	9	2	2
R:R:P178	R:R:V177	5.3	1	Yes	No	5	5	1	1
R:R:K182	R:R:P178	3.35	1	Yes	Yes	4	5	1	1
R:R:F240	R:R:P178	5.78	1	No	Yes	5	5	2	1
R:R:K182	R:R:Q181	8.14	1	Yes	Yes	4	6	1	1
R:R:Q181	R:R:S184	2.89	1	Yes	No	6	8	1	2
R:R:E236	R:R:K182	9.45	1	Yes	Yes	5	4	2	1
R:R:V185	R:R:Y281	3.79	1	No	Yes	7	6	2	2
R:R:V185	R:R:W336	7.36	1	No	Yes	7	8	2	1
R:R:E236	R:R:F240	8.16	1	Yes	No	5	5	2	2
R:R:E236	R:R:K273	8.1	1	Yes	Yes	5	7	2	2
R:R:I243	R:R:L256	2.85	0	No	No	1	4	2	1
R:R:M245	R:R:Y247	5.99	2	Yes	Yes	1	2	1	1
R:R:L252	R:R:M245	4.24	2	Yes	Yes	3	1	1	1
R:R:I254	R:R:M245	2.92	2	Yes	Yes	4	1	1	1
R:R:K248	R:R:Y247	14.33	0	No	Yes	1	2	2	1
R:R:L252	R:R:Y247	3.52	2	Yes	Yes	3	2	1	1
R:R:I254	R:R:L252	2.85	2	Yes	Yes	4	3	1	1
R:R:I254	R:R:L256	2.85	2	Yes	No	4	4	1	1
R:R:K273	R:R:L277	8.46	1	Yes	Yes	7	6	2	1
R:R:L277	R:R:W276	3.42	0	Yes	Yes	6	4	1	2
R:R:L277	R:R:Y281	4.69	0	Yes	Yes	6	6	1	2
R:R:F278	R:R:F282	9.65	1	No	Yes	6	8	2	2
R:R:F278	R:R:H340	3.39	1	No	Yes	6	8	2	1
R:R:F282	R:R:H340	10.18	1	Yes	Yes	8	8	2	1
R:R:L339	R:R:W336	7.97	1	No	Yes	6	8	1	1
R:R:H340	R:R:W336	7.41	1	Yes	Yes	8	8	1	1
R:R:A375	R:R:W336	10.37	0	No	Yes	8	8	2	1
R:R:N378	R:R:W336	7.91	0	No	Yes	9	8	2	1
R:R:I372	R:R:L339	2.85	1	No	No	6	6	2	1
R:R:D368	R:R:S342	10.31	1	No	No	4	5	1	2
R:R:K346	R:R:L347	4.23	0	No	No	4	5	1	2
R:R:R357	R:R:Y350	15.43	0	No	No	5	2	2	1
R:R:Q352	R:R:R357	16.35	0	No	No	1	5	1	2
R:R:L365	R:R:Y369	8.21	2	No	Yes	3	3	1	1
R:R:I153	R:R:Q181	2.74	0	No	Yes	5	6	2	1
R:R:E165	R:R:I96	2.73	0	No	Yes	4	5	2	1
R:R:L361	R:R:Y350	2.34	0	No	No	3	2	1	1
R:R:L252	R:R:S250	1.5	2	Yes	No	3	1	1	2
L:L:A11	R:R:Y350	1.33	0	No	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HBD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.83
Number of Linked Nodes	299
Number of Links	338
Number of Hubs	45
Number of Links mediated by Hubs	156
Number of Communities	7
Number of Nodes involved in Communities	74
Number of Links involved in Communities	108

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	61719
Length Of Smallest Path	3
Average Path Length	16.9434
Length of Longest Path	38
Minimum Path Strength	1.375
Average Path Strength	6.01236
Maximum Path Strength	22.66
Minimum Path Correlation	0.7
Average Path Correlation	0.93168
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	46.5098
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.6316
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • peptide receptor activity • molecular transducer activity • endothelin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • angiotensin receptor binding • signaling receptor binding • type 1 angiotensin receptor binding • G protein-coupled receptor binding • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • regulation of penile erection • regulation of reproductive process • reproductive process • multicellular organismal reproductive process • positive regulation of biological process • mating behavior • behavior • positive regulation of penile erection • positive regulation of multicellular organismal process • reproductive behavior • penile erection • copulation • positive regulation of reproductive process • cell surface receptor signaling pathway • canonical Wnt signaling pathway • Wnt signaling pathway • renal filtration cell differentiation • kidney epithelium development • cellular developmental process • glomerular epithelial cell differentiation • epithelial cell differentiation • renal system development • cell differentiation • nephron development • nephron epithelium development • epithelial cell differentiation involved in kidney development • epithelium development • glomerular epithelium development • tissue development • glomerulus development • cell differentiation involved in kidney development • podocyte differentiation • kidney development • regulation of systemic arterial blood pressure by renin-angiotensin • protein localization • renin secretion into blood stream • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • establishment of protein localization • cellular localization • nitrogen compound transport • transport • protein localization to extracellular region • localization • secretion by cell • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • signal release • cellular macromolecule localization • renal system process involved in regulation of systemic arterial blood pressure • renal system process • secretion • regulation of blood pressure • establishment of protein localization to extracellular region • export from cell • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • protein secretion • establishment of localization • regulation of systemic arterial blood pressure • endocrine process • protein transport • macromolecule localization • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • renal absorption • renal albumin absorption • renal protein absorption • smooth muscle cell differentiation • digestive system development • tube development • muscle cell differentiation • digestive tract development • muscle structure development • enteric smooth muscle cell differentiation • monoatomic ion transmembrane transport • inorganic ion transmembrane transport • calcium ion transport • metal ion transport • inorganic cation transmembrane transport • transmembrane transport • monoatomic cation transmembrane transport • monoatomic ion transport • monoatomic cation transport • calcium ion transmembrane transport • pigmentation • developmental pigmentation • regulation of protein metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of macromolecule metabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • protein metabolic process • macromolecule metabolic process • regulation of metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • protein transmembrane transport • acute-phase response • regulation of defense response • regulation of heat generation • regulation of response to external stimulus • homeostatic process • heat generation • response to stress • regulation of response to stress • acute inflammatory response • fever generation • defense response • regulation of inflammatory response • response to external stimulus • multicellular organismal-level homeostasis • regulation of response to stimulus • temperature homeostasis • regulation of fever generation • regulation of acute inflammatory response • inflammatory response • nervous system development • pharynx development • chordate pharynx development • RNA metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • transcription by RNA polymerase II • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • negative regulation of DNA-templated transcription • negative regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • negative regulation of RNA metabolic process • response to sodium phosphate • response to salt • response to endothelin • response to peptide hormone • renal sodium ion transport • renal sodium ion absorption • sodium ion transport • excretion • renal sodium excretion • sodium ion homeostasis • inorganic ion homeostasis • renal tubular secretion • chemical homeostasis • monoatomic ion homeostasis • monoatomic cation homeostasis • multicellular organismal response to stress • response to pain • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • regulation of pH • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of developmental process • cell development • regulation of cell differentiation • regulation of neuron maturation • regulation of cell development • neurogenesis • negative regulation of neuron maturation • neuron differentiation • negative regulation of cell differentiation • cell maturation • regulation of cell maturation • negative regulation of developmental process • developmental maturation • generation of neurons • negative regulation of cell development • anatomical structure maturation • neuron development • neuron maturation • negative regulation of cell maturation • regulation of neuron differentiation • vascular associated smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • muscle system process • smooth muscle contraction • vein smooth muscle contraction • cGMP-mediated signaling • epithelial fluid transport • transepithelial transport • fluid transport • pigment cell differentiation • melanocyte differentiation • regulation of body fluid levels • positive regulation of urine volume • regulation of urine volume • posterior midgut development • midgut development • biological process involved in interspecies interaction between organisms • response to other organism • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • response to biotic stimulus • cellular response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • calcium-mediated signaling • stem cell development • neural crest cell differentiation • neural crest cell development • mesenchyme development • mesenchymal cell migration • stem cell differentiation • ameboidal-type cell migration • cell migration • mesenchymal cell differentiation • cell motility • neural crest cell migration • regulation of molecular function • negative regulation of lyase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • positive regulation of cell population proliferation • regulation of cell population proliferation • vasodilation • endothelin receptor signaling pathway • regulation of epithelial cell proliferation • epithelial cell proliferation • endothelial cell differentiation • endothelium development • endothelial cell development • epithelial cell development • establishment of endothelial barrier • peripheral nervous system development • ketone metabolic process • regulation of hormone levels • steroid metabolic process • alcohol metabolic process • C21-steroid hormone metabolic process • hormone metabolic process • aldehyde metabolic process • mineralocorticoid metabolic process • aldosterone metabolic process • olefinic compound metabolic process • small molecule metabolic process • primary alcohol metabolic process • lipid metabolic process • cell chemotaxis • chemotaxis • macrophage chemotaxis • macrophage migration • leukocyte migration • taxis • immune system process • mononuclear cell migration • myeloid leukocyte migration • leukocyte chemotaxis • locomotion • enteric nervous system development • autonomic nervous system development • neuroblast migration • carbohydrate derivative metabolic process • proteoglycan metabolic process • glycoprotein metabolic process • heparin proteoglycan metabolic process • nuclear membrane • organelle envelope • nuclear envelope
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P24530
Sequence	>8HBD_nogp_Chain_R C Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N K C M R N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A E D W P F G A M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S W S R I K G I G V P K W T A V E I V L I W V V S V V L A V P E A I G F D I I T M D Y K G S Y L R I C L L H P V Q K T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R L N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y N Q N D P N R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K N C F K S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZRT	A	Peptide	Endothelin	ET_B	Homo sapiens	ET-1	-	-	3.62	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWQ	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/β1/γ2	4.6	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWQ (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		4.6	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWP	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/β1/γ2	3.21	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XWP (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		3.21	2024-10-02	doi.org/10.1038/s42003-024-06905-z
	8XVH	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	chim(Gs-CtGq)/β1/γ2	3.26	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVH (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		3.26	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVE	A	Peptide	Endothelin	ET_B	Homo sapiens	BQ3020	-	chim(Gs-CtGq)/β1/γ2	3	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVE (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	BQ3020	-		3	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8IY6	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	3.13	2023-08-16	10.7554/eLife.85821
	8IY5	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	Gi1/β1/γ2	2.8	2023-08-16	10.7554/eLife.85821
	8IY5 (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		2.8	2023-08-16	10.7554/eLife.85821
	8HCX	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.5	2023-03-22	10.1038/s41467-023-36998-9
	8HCX (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-		3.5	2023-03-22	10.1038/s41467-023-36998-9
	8HBD	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-	Gi1/β1/γ2	2.99	2023-03-22	10.1038/s41467-023-36998-9
	8HBD (No Gprot)	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-		2.99	2023-03-22	10.1038/s41467-023-36998-9
	6LRY	A	Peptide	Endothelin	ET_B	Homo sapiens	Sarafotoxin-B	-	-	3	2020-02-12	10.1016/j.bbrc.2019.12.091
	6K1Q	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL2500	-	-	2.7	2019-07-17	10.1038/s42003-019-0482-7
	6IGL	A	Peptide	Endothelin	ET_B	Homo sapiens	IRL1620	-	-	2.7	2018-11-21	10.1038/s41467-018-07094-0
	6IGK	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-3	-	-	2	2018-11-21	10.1038/s41467-018-07094-0
	5XPR	A	Peptide	Endothelin	ET_B	Homo sapiens	Bosentan	-	-	3.6	2017-08-16	10.1038/nsmb.3450
	5X93	A	Peptide	Endothelin	ET_B	Homo sapiens	K-8794	-	-	2.2	2017-08-16	10.1038/nsmb.3450
	5GLI	A	Peptide	Endothelin	ET_B	Homo sapiens	-	-	-	2.5	2016-09-07	10.1038/nature19319
	5GLH	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	2.8	2016-09-07	10.1038/nature19319

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HBD_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.