Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I47 6.41167615
2R:R:Y51 5.3325407
3R:R:I54 2.54407
4R:R:F55 4.8675407
5R:R:Y82 5.2325408
6R:R:L86 5.2375429
7R:R:D90 7.018529
8R:R:L97 6.755408
9R:R:Y103 5.3625415
10R:R:Y104 5.37415
11R:R:W110 7.27143719
12R:R:M128 6.1825417
13R:R:F134 9.338538
14R:R:Y143 5.36408
15R:R:V146 4.778569
16R:R:I147 10.0375467
17R:R:W168 5.435439
18R:R:F181 10.5925414
19R:R:V184 4.2525416
20R:R:M197 7.4675414
21R:R:F199 10.27614
22R:R:W207 11.635416
23R:R:I211 4.8375415
24R:R:F220 8.0325408
25R:R:L224 3.395406
26R:R:I227 4.1725408
27R:R:Y231 5.765649
28R:R:R235 5.98445
29R:R:W269 5.30571719
30R:R:F272 5.684516
31R:R:H273 9.7225418
32R:R:T276 4.5775406
33R:R:I287 3.8425491
34R:R:N314 7.215429
35R:R:P315 6.1325409
36R:R:L317 3.8825428
37R:R:Y318 7.742529
38R:R:K328 8.5575484
39L:L:?1 10.43671510
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I304 R:R:Y51 13.06313.63NoYes057
2R:R:F55 R:R:L97 41.99343.65YesYes078
3R:R:F55 R:R:P98 30.59148.67YesNo079
4R:R:P98 R:R:Y52 28.64455.56NoNo095
5R:R:P315 R:R:V61 10.47847.07YesNo098
6R:R:N62 R:R:P315 31.98678.15NoYes099
7R:R:D90 R:R:N62 33.7016.73YesNo099
8R:R:D90 R:R:N314 37.80736.73YesYes299
9R:R:N310 R:R:N314 97.98016.81NoYes099
10R:R:N310 R:R:W269 99.84055.65NoYes099
11L:L:?1 R:R:W269 1003.62YesYes109
12L:L:?1 R:R:Y108 15.65453.73YesNo105
13R:R:Y104 R:R:Y108 14.77082.98YesNo155
14L:L:?1 R:R:I304 16.279115.14YesNo005
15R:R:A87 R:R:V65 14.5053.39NoNo099
16R:R:P315 R:R:V65 19.24923.53YesNo099
17R:R:M138 R:R:Y318 34.830611.97NoYes099
18R:R:I135 R:R:Y318 62.83723.63NoYes289
19R:R:I135 R:R:N314 61.24927.08NoYes289
20R:R:F84 R:R:V66 10.95682.62NoNo067
21R:R:A87 R:R:V66 12.73751.7NoNo097
22R:R:M138 R:R:Y82 28.32564.79NoYes098
23R:R:C137 R:R:Y82 18.19935.38NoYes078
24R:R:C137 R:R:F134 16.43852.79NoYes078
25R:R:L126 R:R:S175 10.59146.01NoNo056
26R:R:S175 R:R:T125 12.67113.2NoNo064
27L:L:?1 R:R:T125 14.551510.94YesNo104
28R:R:F308 R:R:L97 48.684415.83NoYes078
29R:R:W110 R:R:Y103 26.33892.89YesYes195
30R:R:D109 R:R:Y106 20.72432.3NoNo055
31R:R:T102 R:R:Y106 22.72432.5NoNo045
32R:R:T102 R:R:Y52 24.7112.5NoNo045
33R:R:D109 R:R:V192 18.7115.84NoNo053
34R:R:V184 R:R:W110 10.35228.58YesYes169
35R:R:F129 R:R:M128 15.40867.46NoYes077
36L:L:?1 R:R:M128 12.98348.25YesYes107
37R:R:I132 R:R:M128 15.40864.37NoYes087
38R:R:I132 R:R:P223 13.52823.39NoNo089
39R:R:I227 R:R:L224 88.26582.85YesYes086
40R:R:F265 R:R:L224 85.76084.87NoYes096
41R:R:F265 R:R:W269 88.4124.01NoYes099
42R:R:I227 R:R:S139 68.996.19YesNo089
43R:R:C230 R:R:S139 67.50833.44NoNo079
44R:R:R142 R:R:Y318 27.97348.23NoYes099
45R:R:F325 R:R:R142 26.245814.97NoNo089
46R:R:I147 R:R:Y143 33.468410.88YesYes078
47R:R:C230 R:R:Y143 62.98344.03NoYes078
48R:R:I234 R:R:Y143 26.47843.63NoYes088
49R:R:I147 R:R:V146 24.93693.07YesYes679
50R:R:I234 R:R:V146 24.77749.22NoYes089
51R:R:L238 R:R:V146 42.93024.47NoYes089
52L:L:?1 R:R:M197 28.31237.5YesYes104
53R:R:F181 R:R:M197 11.73424.98YesYes144
54R:R:F199 R:R:M197 14.91036.22YesYes144
55L:L:?1 R:R:K215 15.614620.93YesNo004
56R:R:A194 R:R:I187 10.52491.62NoNo042
57R:R:I187 R:R:V192 12.59143.07NoNo023
58R:R:L281 R:R:V286 13.06988.94NoNo051
59R:R:F277 R:R:L281 34.5989.74NoNo065
60R:R:F277 R:R:N216 38.86383.62NoNo066
61R:R:H273 R:R:N216 29.91367.65YesNo086
62R:R:H273 R:R:W269 24.6916.35YesYes189
63R:R:F272 R:R:H273 11.34229.05YesYes168
64L:L:?1 R:R:F272 23.8145.81YesYes106
65R:R:N216 R:R:T276 14.03325.85NoYes066
66R:R:F272 R:R:T276 15.11637.78YesYes066
67R:R:K215 R:R:T276 11.94683NoYes046
68R:R:F220 R:R:F265 13.63466.43YesNo089
69R:R:F220 R:R:H273 21.169415.84YesYes088
70R:R:F220 R:R:L270 16.7116.09YesNo086
71R:R:I227 R:R:V262 21.09634.61YesNo088
72R:R:V262 R:R:Y231 17.34883.79NoYes089
73R:R:L238 R:R:V332 35.98011.49NoNo085
74R:R:T250 R:R:V332 32.43853.17NoNo055
75R:R:N247 R:R:T250 25.52821.46NoNo045
76R:R:N247 R:R:S243 14.66454.47NoNo043
77R:R:K328 R:R:V254 21.03656.07YesNo048
78R:R:F325 R:R:V254 22.73092.62NoNo088
79R:R:I287 R:R:L281 17.4021.43YesNo015
80R:R:A212 R:R:T276 10.81061.68NoYes056
81L:L:?1 R:R:F308 51.980114.85YesNo007
82L:L:?1 R:R:Y103 31.07645.59YesYes105
83R:R:M128 R:R:W269 18.74424.65YesYes179
84R:R:F272 R:R:W269 10.74423.01YesYes169
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L97 R:R:Y51 4.69 0 Yes Yes 8 7 2 2
R:R:I304 R:R:Y51 3.63 0 No Yes 5 7 1 2
R:R:F308 R:R:L93 4.87 0 No No 7 7 1 2
R:R:T96 R:R:W100 8.49 0 No No 7 7 2 1
R:R:F308 R:R:L97 15.83 0 No Yes 7 8 1 2
R:R:L124 R:R:W100 11.39 1 No No 6 7 1 1
L:L:?1 R:R:W100 14.49 1 Yes No 0 7 0 1
R:R:Y103 R:R:Y108 8.94 1 Yes No 5 5 1 1
R:R:W110 R:R:Y103 2.89 1 Yes Yes 9 5 2 1
R:R:C195 R:R:Y103 4.03 1 No Yes 9 5 2 1
L:L:?1 R:R:Y103 5.59 1 Yes Yes 0 5 0 1
R:R:Y104 R:R:Y108 2.98 1 Yes No 5 5 2 1
L:L:?1 R:R:Y108 3.73 1 Yes No 0 5 0 1
R:R:C195 R:R:W110 9.14 1 No Yes 9 9 2 2
R:R:S122 R:R:T178 3.2 0 No No 6 5 2 1
L:L:?1 R:R:L124 11.74 1 Yes No 0 6 0 1
R:R:S175 R:R:T125 3.2 0 No No 6 4 2 1
R:R:T125 R:R:T178 10.99 1 No No 4 5 1 1
L:L:?1 R:R:T125 10.94 1 Yes No 0 4 0 1
R:R:F129 R:R:M128 7.46 0 No Yes 7 7 2 1
R:R:I132 R:R:M128 4.37 0 No Yes 8 7 2 1
R:R:M128 R:R:W269 4.65 1 Yes Yes 7 9 1 1
L:L:?1 R:R:M128 8.25 1 Yes Yes 0 7 0 1
L:L:?1 R:R:T178 7.03 1 Yes No 0 5 0 1
R:R:F181 R:R:M197 4.98 1 Yes Yes 4 4 2 1
R:R:F181 R:R:F199 19.29 1 Yes Yes 4 4 2 2
R:R:M197 R:R:R182 11.17 1 Yes No 4 5 1 1
L:L:?1 R:R:R182 25.12 1 Yes No 0 5 0 1
R:R:F199 R:R:M197 6.22 1 Yes Yes 4 4 2 1
L:L:?1 R:R:M197 7.5 1 Yes Yes 0 4 0 1
R:R:F199 R:R:I211 10.05 1 Yes Yes 4 5 2 2
R:R:I211 R:R:K215 2.91 1 Yes No 5 4 2 1
R:R:K215 R:R:T276 3 0 No Yes 4 6 1 2
L:L:?1 R:R:K215 20.93 1 Yes No 0 4 0 1
R:R:F265 R:R:W269 4.01 0 No Yes 9 9 2 1
R:R:F272 R:R:W269 3.01 1 Yes Yes 6 9 1 1
R:R:H273 R:R:W269 6.35 1 Yes Yes 8 9 2 1
R:R:G307 R:R:W269 9.85 0 No Yes 8 9 2 1
R:R:N310 R:R:W269 5.65 0 No Yes 9 9 2 1
L:L:?1 R:R:W269 3.62 1 Yes Yes 0 9 0 1
R:R:F272 R:R:H273 9.05 1 Yes Yes 6 8 1 2
R:R:F272 R:R:T276 7.78 1 Yes Yes 6 6 1 2
L:L:?1 R:R:F272 5.81 1 Yes Yes 0 6 0 1
R:R:I304 R:R:L300 2.85 0 No No 5 4 1 2
L:L:?1 R:R:I304 15.14 1 Yes No 0 5 0 1
L:L:?1 R:R:F308 14.85 1 Yes No 0 7 0 1
R:R:A303 R:R:F272 2.77 0 No Yes 7 6 2 1
L:L:?1 R:R:G121 1.81 1 Yes No 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
76.47Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
70.59Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
70.59Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
68.42Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
66.67Consensusendothelin_offOrthosteric Ligandetb_off
66.67Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
64.71Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
64.71Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
62.50Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
58.82Single5WQCEMPA5WQC-OX2-EMPA
57.89Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
57.89Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
56.25Single4ZJCSB-6740424ZJC-OX1-SB-674042
56.25Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
56.25Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
56.25Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
55.56Single5X93K-87945X93-ETB-K-8794
55.56Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
55.56Single6TQ7SB-3348676TQ7-OX1-SB-334867
55.56Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
55.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
53.85Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
53.33Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
52.94Single2Y04Salbutamol2Y04-β1-Salbutamol
52.94Single3NY8ICI 118-5513NY8-β2-ICI 118-551
52.94Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
52.94Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
52.94Single4YAYZD-71554YAY-AT1-ZD-7155
52.94Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
52.94Single6TOTLemborexant6TOT-OX1-Lemborexant
52.94Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
52.94Single7UL4Alvimopan7UL4-μ-Alvimopan
52.94Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
52.94Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
52.94Single8K5DGSK2560738K5D-HCA2-GSK256073
52.94Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
52.63Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
52.63Single6ZG4HTL00099366ZG4-M1-HTL0009936
52.63Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
52.63Single7YITNalfurafine7YIT-κ-Nalfurafine
52.63Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
52.63Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
52.63Consensusgs_steroidOrthosteric Ligandgs_bileacid
52.63Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
52.63Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
52.38Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
50.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
50.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
50.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
50.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
50.00Single5WIUNemonapride5WIU-D4-Nemonapride
50.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
50.00Single5WS3EMPA5WS3-OX2-EMPA
50.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
50.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
50.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
50.00Single6TODEMPA6TOD-OX1-EMPA-Na
50.00Single6TP6Filorexant6TP6-OX1-Filorexant
50.00Single7XRRLemborexant7XRR-OX2-Lemborexant
50.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
50.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
50.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
50.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
50.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGVEpinephrine8GGV-β2-Epinephrine
50.00Single8GGWEpinephrine8GGW-β2-Epinephrine
50.00Single8GGXEpinephrine8GGX-β2-Epinephrine
50.00Single8GH0Epinephrine8GH0-β2-Epinephrine
50.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8IWESpermidine8IWE-TAAR9-Spermidine
50.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
50.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
50.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
50.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
50.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
50.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
50.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
50.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
50.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
50.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
50.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
50.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
50.00Consensussteroid_onOrthosteric Ligandbileacid_on
50.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
47.83Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
47.62Single7SK9CCX6627SK9-ACKR3-CCX662
47.62Single8X5YAstemizole8X5Y-H1-Astemizole
47.62Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
47.37Single2YDVNECA2YDV-A2A-NECA
47.37Single4DJHJDTic4DJH-κ-JDTic
47.37Single4UHRCGS216804UHR-A2A-CGS21680
47.37Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
47.37Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
47.37Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
47.37Single5G53NECA5G53-A2A-NECA-Gs
47.37Single6H7JIsoprenaline6H7J-β1-Isoprenaline
47.37Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
47.37Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
47.37Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
47.37Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
47.37Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
47.37Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
47.37Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
47.37Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
47.37Single8E0GBU728E0G-μ-BU72
47.37Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
47.37Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
47.37Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
47.37Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
47.37Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
47.37Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
47.37Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
47.37Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
47.37Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
47.06Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
47.06Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
47.06Single6PS4ICI 118-5516PS4-β2-ICI 118-551
47.06Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
47.06Single6TPGEMPA6TPG-OX2-EMPA
47.06Single6TPNHTL66416TPN-OX2-HTL6641
47.06Single6V9SGTPL114036V9S-OX1-GTPL11403
47.06Single6ZG9GSK10347026ZG9-M1-GSK1034702
47.06Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
47.06Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
47.06Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
47.06Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8GGIEpinephrine8GGI-β2-Epinephrine
47.06Single8GGQEpinephrine8GGQ-β2-Epinephrine
47.06Single8GGTEpinephrine8GGT-β2-Epinephrine
47.06Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
47.06Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
47.06Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
47.06Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
46.67Single8GGREpinephrine8GGR-β2-Epinephrine
46.67Single8GGZEpinephrine8GGZ-β2-Epinephrine
45.83Single7C61Ergotamine7C61-5-HT1B-Ergotamine
45.45Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
45.45Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
45.45Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
45.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
45.00Single4AMIBucindolol4AMI-β1-Bucindolol
45.00Single4LDEBI1671074LDE-β2-BI167107
45.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
45.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
45.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
45.00Single7DFPSpiperone7DFP-D2-Spiperone
45.00Single7K15MKD0467K15-BLT1-MKD046-Na
45.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
45.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
45.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
45.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
45.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
45.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
45.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
45.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
45.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
45.00Consensusblt_offOrthosteric Ligandblt1_off
45.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
45.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
45.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
44.44Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
44.44Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
44.44Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
44.44Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
44.44Single4EJ4Naltrindole4EJ4-δ-Naltrindole
44.44Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
44.44Single6H7MSalbutamol6H7M-β1-Salbutamol
44.44Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
44.44Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
44.44Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
44.44Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
44.44Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
44.44Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
44.44Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
44.44Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
44.44Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
44.44Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
44.44Single7WC7Lisuride7WC7-5-HT2A-Lisuride
44.44Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
44.44Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
44.44Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
44.44Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
44.44Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
44.44Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GGJEpinephrine8GGJ-β2-Epinephrine
44.44Single8GGNEpinephrine8GGN-β2-Epinephrine
44.44Single8GGOEpinephrine8GGO-β2-Epinephrine
44.44Single8GGUEpinephrine8GGU-β2-Epinephrine
44.44Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
44.44Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
44.44Single8JJOAlprenolol8JJO-β2-Alprenolol
44.44Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
44.44Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
44.44Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
44.44Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
44.44Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
44.44Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
44.44Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
44.44Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
44.44Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
44.44Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
44.44Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
44.44Consensusblt_onOrthosteric Ligandblt1_on
44.44Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
44.44Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
44.44Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
44.44Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
44.44Consensusgi_hcarOrthosteric Ligandgi_hca
44.44Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
44.44Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
44.44Consensusleuko_onOrthosteric Ligandblt_on
44.44Consensustar_onOrthosteric Ligandta1_on
44.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
44.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
43.75Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
43.75Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8GGSEpinephrine8GGS-β2-Epinephrine
43.75Single8GGYEpinephrine8GGY-β2-Epinephrine
43.75Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
43.75Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
43.48Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
43.48Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
43.48Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
42.86Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
42.86Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
42.86Single6H7LDobutamine6H7L-β1-Dobutamine
42.86Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
42.86Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
42.86Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
42.86Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
42.86Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
42.86Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
42.86Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
42.86Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
42.86Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
42.86Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
42.86Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
42.86Consensusorexin_onOrthosteric Ligandox2_on
42.31Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
42.31Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.31Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single2Y00Dobutamine2Y00-β1-Dobutamine
42.11Single5C1MBU725C1M-μ-BU72
42.11Single6D26Fevipiprant6D26-DP2-Fevipiprant
42.11Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
42.11Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
42.11Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
42.11Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
42.11Single6PS6Timolol6PS6-β2-Timolol
42.11Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
42.11Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
42.11Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
42.11Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
42.11Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
42.11Single7XKAEpinephrine7XKA-β2-Epinephrine
42.11Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
42.11Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
42.11Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
42.11Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
42.11Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
42.11Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
42.11Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
42.11Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
42.11Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
42.11Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
42.11Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
42.11Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
42.11Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
42.11Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
41.67Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
41.67Single6PT2KGCHM076PT2-δ-KGCHM07
41.67Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
41.67Consensusangiotensin_onOrthosteric Ligandat1_on
41.67Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
41.67Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
41.18Single4S0VSuvorexant4S0V-OX2-Suvorexant
41.18Single6AKXA4R6AKX-CCR5-A4R
41.18Single6AKYMaraviroc6AKY-CCR5-Maraviroc
41.18Single6KUXRS-799486KUX-α2a-RS-79948
41.18Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
41.18Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
41.18Single6TPJSuvorexant6TPJ-OX2-Suvorexant
41.18Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
41.18Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
41.18Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
41.18Single8IHKAcifran8IHK-HCA3-Acifran
41.18Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
41.18Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
41.18Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
41.18Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
41.18Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
41.18Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
40.91Single3NY9PubChem 9131033NY9-β2-PubChem 913103
40.91Single4UG2CGS216804UG2-A2A-CGS21680
40.91Single5ZTYAM102575ZTY-CB2-AM10257
40.91Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
40.91Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
40.91Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
40.91Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
40.91Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
40.91Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
40.91Consensuslpl_offOrthosteric Ligands1p_off lpa_off
40.91Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
40.74Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
40.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
40.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
40.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
40.00Single4U15Tiotropium4U15-M3-Tiotropium
40.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
40.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
40.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
40.00Single6J20Aprepitant6J20-NK1-Aprepitant
40.00Single6J21Aprepitant6J21-NK1-Aprepitant
40.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
40.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
40.00Single6OL9Tiotropium6OL9-M5-Tiotropium
40.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
40.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
40.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
40.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
40.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
40.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
40.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
40.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
40.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
40.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
40.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
40.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
40.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
40.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
40.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
40.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
40.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
40.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
40.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
40.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
40.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
40.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
40.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
40.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
40.00Consensushistamine_offOrthosteric Ligandh1_off
40.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
40.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
40.00Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
40.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
40.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
40.00Consensussensory_onOrthosteric Ligandopsin_on
39.29Single6IGLIRL16206IGL-ETB-IRL1620
39.29Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
39.13Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
39.13Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
39.13Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
39.13Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
39.13Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
39.13Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
39.13Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
39.13Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.13Consensussst_onOrthosteric Ligandsst2_on sst4_on
38.89Single2YDOAdenosine2YDO-A2A-Adenosine
38.89Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
38.89Single4MBSMaraviroc4MBS-CCR5-Maraviroc
38.89Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
38.89Single6A94Zotepine6A94-5-HT2A-Zotepine
38.89Single6IQLL7458706IQL-D4-L745870
38.89Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
38.89Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
38.89Single6TP3Nemorexant6TP3-OX1-Nemorexant
38.89Single6TPKRetosiban6TPK-OT-Retosiban
38.89Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
38.89Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
38.89Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
38.89Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
38.89Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
38.89Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
38.89Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
38.89Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
38.89Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
38.89Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GGKEpinephrine8GGK-β2-Epinephrine
38.89Single8GGMEpinephrine8GGM-β2-Epinephrine
38.89Single8GGPEpinephrine8GGP-β2-Epinephrine
38.89Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
38.89Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
38.89Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
38.89Single8K5CAcipimox8K5C-HCA2-Acipimox
38.89Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
38.89Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
38.89Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
38.89Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
38.89Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
38.89Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
38.89Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
38.89Consensushca_onOrthosteric Ligandhca2_on hca3_on
38.89Consensushcar_onOrthosteric Ligandhca_on
38.89Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
38.89Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
38.89Consensusvasopressin-ot_offOrthosteric Ligandot_off
38.46Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
38.10Single5CXVTiotropium5CXV-M1-Tiotropium
38.10Single6A93Risperidone6A93-5-HT2A-Risperidone
38.10Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
38.10Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
38.10Single6HLPNetupitant6HLP-NK1-Netupitant
38.10Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
38.10Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
38.10Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
38.10Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
38.10Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
38.10Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
38.10Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
38.10Single8JJ8Formoterol8JJ8-β2-Formoterol
38.10Single8JJLOlodaterol8JJL-β2-Olodaterol
38.10Single8JWZAB9288JWZ-A2A-AB928-Na
38.10Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
38.10Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
38.10Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
38.10Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
38.10Consensusdp_offOrthosteric Liganddp2_off
38.10Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
38.10Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
38.10Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
38.10Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
37.93Single5GLHEndothelin-15GLH-ETB-Endothelin-1
37.93Single6IGKEndothelin-36IGK-ETB-Endothelin-3
37.50Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
37.50Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
37.50Single6HLOAprepitant6HLO-NK1-Aprepitant
37.50Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
37.50Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
37.50Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
37.50Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
37.50Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
37.50Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
37.50Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
37.04Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
37.04Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
36.84Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
36.84Single2Y01Dobutamine2Y01-β1-Dobutamine
36.84Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
36.84Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
36.84Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
36.84Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
36.84Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
36.84Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
36.84Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
36.84Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
36.84Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
36.84Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
36.84Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
36.84Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
36.84Single6PS1Timolol6PS1-β2-Timolol
36.84Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
36.84Single7BU7BI1671077BU7-β1-BI167107
36.84Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
36.84Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
36.84Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
36.84Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
36.84Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
36.84Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
36.84Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
36.84Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
36.84Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
36.84Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
36.84Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
36.84Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Single8X64Desloratadine8X64-H1-Desloratadine
36.84Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
36.84Consensusadenosine_onOrthosteric Liganda1_on a2_on
36.84Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
36.84Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
36.84Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
36.84Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
36.84Consensushistamine_onOrthosteric Ligandh1_on h4_on
36.84Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
36.84Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
36.84Consensusnucleotide_onOrthosteric Ligandadenosine_on
36.36Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
36.36Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
36.36Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
36.36Single6IBLArformoterol6IBL-β1-Arformoterol
36.36Single6K1QIRL25006K1Q-ETB-IRL2500
36.36Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
36.36Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
36.36Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
36.36Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
36.36Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
36.36Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
36.36Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.36Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
36.36Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.36Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
36.36Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
36.36Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.36Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
36.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
36.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
36.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
36.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
36.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
36.00Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
35.71Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
35.29Single3OE9IT1t3OE9-CXCR4-IT1t
35.29Single3PBLEticlopride3PBL-D3-Eticlopride
35.29Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
35.29Single6HLLCP999946HLL-NK1-CP99994
35.29Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
35.29Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single8GH1Epinephrine8GH1-β2-Epinephrine
35.29Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
35.29Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
35.29Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
35.29Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
35.29Single8K5BNiacin8K5B-HCA2-Niacin
35.29Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
35.29Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
35.29Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
35.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
35.00Single5TVNLSD5TVN-5-HT2B-LSD
35.00Single5XPRBosentan5XPR-ETB-Bosentan
35.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
35.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
35.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
35.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
35.00Single7C4SS1P7C4S-S1P3-S1P
35.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
35.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
35.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
35.00Single7SINNPS-21437SIN-CaS-NPS-2143
35.00Single7SINNPS-21437SIN-CaS-NPS-2143
35.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
35.00Single7WC6LSD7WC6-5-HT2A-LSD
35.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
35.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
35.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
35.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
35.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
35.00Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
35.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
35.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
35.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
35.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.78Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
34.78Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
34.78Single6PT3DPI-2876PT3-δ-DPI-287
34.78Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
34.78Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.78Single7XN9L-054,5227XN9-SST2-L-054,522
34.78Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
34.78Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
34.78Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
34.78Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
34.78Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
34.78Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
34.78Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.78Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
34.78Consensuslpl_onOrthosteric Ligands1p_on lpa_on
34.62Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
34.62Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
34.62Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
34.62Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
34.62Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
34.48Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
34.48Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
33.33Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
33.33Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
33.33Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
33.33Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
33.33Single3P0GBI1671073P0G-β2-BI167107
33.33Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
33.33Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
33.33Single4IARErgotamine4IAR-5-HT1B-Ergotamine
33.33Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
33.33Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
33.33Single5DHHSB-6121115DHH-NOP-SB-612111
33.33Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
33.33Single6E59L-7607356E59-NK1-L-760735
33.33Single6ME2Ramelteon6ME2-MT1-Ramelteon
33.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
33.33Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
33.33Single6WGTLSD6WGT-5-HT2A-LSD
33.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
33.33Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
33.33Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
33.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
33.33Single7TUYGSK682753A7TUY-GPR183-GSK682753A
33.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
33.33Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
33.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
33.33Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7W41PD1762527W41-BB2-PD176252
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
33.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
33.33Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
33.33Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
33.33Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
33.33Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
33.33Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
33.33Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
33.33Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
33.33Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
33.33Consensus5ht5_offOrthosteric Ligand5ht5a_off
33.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
33.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
33.33Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
33.33Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
33.33Consensusbombesin_offOrthosteric Ligandbb2_off
33.33Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
33.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
33.33Consensusgt_class-aOrthosteric Ligandgt_opsin
33.33Consensusgt_opsinOrthosteric Ligandgt_sensory
33.33Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Consensuslpa_offOrthosteric Ligandlpa1_off
33.33Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
33.33Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
33.33Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
32.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
32.14Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.14Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
32.14Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
32.00Single3QAKUK-4320973QAK-A2A-UK-432097
32.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
32.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
32.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
32.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
32.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
32.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
32.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
31.82Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
31.82Single6CM4Risperidone6CM4-D2-Risperidone
31.82Single6MXTSalmeterol6MXT-β2-Salmeterol
31.82Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
31.82Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
31.82Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
31.82Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
31.82Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
31.82Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
31.82Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.82Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
31.82Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
31.82Single8WU1KCA8WU1-CB1-KCA-Arrestin1
31.82Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
31.82Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
31.82Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
31.82Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
31.82Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.82Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
31.58Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
31.58Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
31.58Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
31.58Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
31.58Single6VI4JDTic6VI4-κ-JDTic
31.58Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
31.58Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
31.58Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
31.58Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
31.58Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
31.58Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
31.58Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
31.58Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
31.58Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.58Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
31.58Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
31.58Single8GGLEpinephrine8GGL-β2-Epinephrine
31.58Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
31.58Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
31.58Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
31.58Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
31.58Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
31.58Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
31.58Consensus5ht5_onOrthosteric Ligand5ht5a_on
31.58Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
31.58Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
31.58Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.58Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
31.58Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
31.58Consensuss1p_offOrthosteric Ligands1p1_off
31.25Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
31.25Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
31.25Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
31.25Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
31.03Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
31.03Consensusendothelin_onOrthosteric Ligandetb_on eta_on
30.77Single5WF5UK-4320975WF5-A2A-UK-432097
30.77Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
30.77Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
30.77Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
30.77Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
30.43Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
30.43Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
30.43Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
30.43Single7EZCUKA7EZC-A2A-UKA
30.43Single7UM4AS26747237UM4-5-HT5A-AS2674723
30.43Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
30.43Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.43Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
30.43Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
30.43Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
30.43Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
30.43Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
30.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
30.00Single2Y02Carmoterol2Y02-β1-Carmoterol
30.00Single4DAJTiotropium4DAJ-M3-Tiotropium
30.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
30.00Single4MQSIperoxo4MQS-M2-Iperoxo
30.00Single4U14Tiotropium4U14-M3-Tiotropium
30.00Single5DSGTiotropium5DSG-M4-Tiotropium
30.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
30.00Single5TGZAM65385TGZ-CB1-AM6538
30.00Single6D27CAY104716D27-DP2-CAY10471
30.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
30.00Single6GPSMK08126GPS-CCR2-MK0812
30.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
30.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
30.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
30.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
30.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
30.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
30.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
30.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
30.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
30.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
30.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
30.00Single8CU6LJ-45178CU6-A2A-LJ-4517
30.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
30.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
30.00Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
30.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
30.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
30.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
30.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
30.00Single8X63Mepyramine8X63-H1-Mepyramine
30.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
30.00Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
30.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
30.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
30.00Consensustachykinin_offOrthosteric Ligandnk1_off
29.63Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
29.63Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
29.63Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
29.63Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
29.41Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
29.41Single3OE6IT1t3OE6-CXCR4-IT1t
29.41Single3OE8IT1t3OE8-CXCR4-IT1t
29.41Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
29.41Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
29.41Single6ME5Agomelatine6ME5-MT1-Agomelatine
29.41Single6ME9Ramelteon6ME9-MT2-Ramelteon
29.41Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
29.41Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
29.41Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
29.41Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
29.41Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
29.41Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
29.41Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Single5WF6UK-4320975WF6-A2A-UK-432097
29.17Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
29.17Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
28.57Single5CGCHTL142425CGC-mGlu5-HTL14242
28.57Single5N2SPSB365N2S-A1-PSB36
28.57Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
28.57Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
28.57Single6GPXMK08126GPX-CCR2-MK0812
28.57Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
28.57Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
28.57Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
28.57Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
28.57Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
28.57Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
28.57Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
28.57Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
28.57Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
28.57Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
28.57Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
28.57Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.57Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
28.57Single8EA0Iperoxo8EA0-M3-Iperoxo
28.57Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
28.57Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
28.57Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
28.57Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
28.57Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.12Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
28.12Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.12Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.12Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
28.00Single4XT1Fractalkine4XT1-US28-Fractalkine
28.00Single7F8XNN90567F8X-CCKA-NN9056
28.00Single7QA8Peptide7QA8-STE2-Peptide
28.00Single7QA8Peptide7QA8-STE2-Peptide
28.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
28.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
28.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
28.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
28.00Consensusclass-d_offOrthosteric Ligandste2_off
28.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
28.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
28.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
28.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
28.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
27.78Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
27.78Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
27.78Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
27.78Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
27.78Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
27.78Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
27.78Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
27.78Single6TP4ACT-4622066TP4-OX1-ACT-462206
27.78Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
27.78Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
27.78Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
27.78Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
27.78Single7SRQLSD7SRQ-5-HT2B-LSD
27.78Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
27.78Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
27.78Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
27.78Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
27.78Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
27.78Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
27.78Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
27.78Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
27.78Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
27.78Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
27.78Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
27.59Single4XT3Fractalkine4XT3-US28-Fractalkine
27.59Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
27.59Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
27.27Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
27.27Single5XR8AM8415XR8-CB1-AM841
27.27Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
27.27Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.27Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
27.27Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
27.27Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
27.27Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
27.27Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
27.27Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
27.27Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
27.27Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
27.27Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
27.27Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
27.27Consensuscck_onOrthosteric Ligandccka_on cckb_on
27.27Consensuschemerin_onOrthosteric Ligandcml1_on
27.27Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
27.27Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.27Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
27.27Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
27.27Consensuslpa_onOrthosteric Ligandlpa1_on
27.27Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
27.27Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
26.92Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
26.92Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
26.92Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
26.92Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
26.92Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
26.67Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
26.67Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
26.67Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
26.67Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
26.67Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
26.67Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
26.67Consensusgo_class-b1Orthosteric Ligandgo_crf
26.67Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
26.67Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
26.47Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.47Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
26.47Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.47Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
26.32Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
26.32Single3ODUIT1t3ODU-CXCR4-IT1t
26.32Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
26.32Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.32Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
26.32Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
26.32Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
26.32Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
26.32Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
26.32Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
26.32Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
26.32Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
26.32Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
26.32Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
26.32Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
26.32Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
26.32Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
26.32Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
26.32Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
26.32Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
26.32Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
26.32Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
26.32Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
26.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.09Single5X33BIIL2605X33-BLT1-BIIL260
26.09Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
26.09Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.09Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.09Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.09Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
26.09Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
26.09Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
26.09Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
26.09Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
26.09Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
26.09Consensusgi_class-fOther Ligandgi_frizzled
26.09Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.09Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
26.09Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.93Single6W25SHU91196W25-MC4-SHU9119-Ca
25.93Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
25.93Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
25.81Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.81Single8IY6Endothelin-18IY6-ETB-Endothelin-1
25.81Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single3RZECidoxepin3RZE-H1-Cidoxepin
25.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single5CGDHTL142425CGD-mGlu5-HTL14242
25.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
25.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
25.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
25.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
25.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
25.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
25.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
25.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
25.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7T32ZM2413857T32-A2A-ZM241385
25.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
25.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
25.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
25.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
25.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
25.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
25.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
25.00Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.00Consensussensory_offOrthosteric Ligandopsin_off
25.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.32Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
24.24Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
24.14Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
24.14Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
24.14Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
24.14Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
24.14Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
24.14Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.14Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
24.00Single5EE7MK08935EE7-Glucagon-MK0893
24.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
24.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
24.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
24.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
24.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Consensusclass-d_offOrthosteric Ligandste2_off
24.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
24.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
24.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
23.81Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
23.81Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.81Single6IIVDaltroban6IIV-TP-Daltroban
23.81Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
23.81Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
23.81Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
23.81Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.81Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
23.81Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
23.81Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
23.81Consensuscck_offOrthosteric Ligandccka_off
23.81Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
23.81Consensushcar_offOrthosteric Ligandsuccinate_off
23.81Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
23.81Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
23.81Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
23.53Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
23.53Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
23.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
23.33Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
23.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
23.33Single7SK3CXCL127SK3-ACKR3-CXCL12
23.33Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
23.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
23.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
23.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
23.08Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
23.08Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
23.08Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.08Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
22.86Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.73Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
22.73Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
22.73Single5NM2ZM2413855NM2-A2A-ZM241385-Na
22.73Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
22.73Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.73Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Single7YXAONO-54306087YXA-S1P5-ONO-5430608
22.73Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
22.73Single8GNEKW-63568GNE-A2A-KW-6356-Na
22.73Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
22.73Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
22.73Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
22.58Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
22.58Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
22.58Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
22.50Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
22.22Single3UZAGTPL92363UZA-A2A-GTPL9236
22.22Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
22.22Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
22.22Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
22.22Single7SK5CXCL127SK5-ACKR3-CXCL12
22.22Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
22.22Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.22Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
22.22Consensuspth_onOrthosteric Ligandpth1_on pth2_on
22.22Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
21.88Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
21.88Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
21.88Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
21.88Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
21.88Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
21.88Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
21.88Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
21.88Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.74Single5XRAAM115425XRA-CB1-AM11542
21.74Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
21.74Single7EPENAM5637EPE-mGlu-NAM563
21.74Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
21.74Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
21.74Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
21.74Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.74Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
21.74Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
21.74Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
21.74Consensusadenosine_offOrthosteric Liganda1_off a2_off
21.74Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
21.74Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.74Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
21.74Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
21.74Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
21.43Single3OE0CVX153OE0-CXCR4-CVX15
21.43Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
21.43Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
21.43Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
21.43Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.21Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
21.21Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
21.05Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
21.05Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
21.05Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
21.05Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
21.05Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
21.05Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
21.05Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Consensusclass-t_onOrthosteric Ligandtaste2_on
21.05Consensusgs_class-tOrthosteric Ligandgs_taste
21.05Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
21.05Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
21.05Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
20.83Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
20.83Single6IIURamatroban6IIU-TP-Ramatroban
20.83Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
20.83Single6OS2TRV0266OS2-AT1-TRV026
20.83Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
20.83Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.83Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
20.83Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
20.83Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
20.83Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
20.83Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
20.69Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
20.69Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.69Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
20.69Consensusclass-d_onOrthosteric Ligandste2_on
20.69Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.69Consensusgi_class-dOrthosteric Ligandgi_ste
20.69Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
20.69Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
20.59Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
20.59Consensusglp_onOrthosteric Ligandglp1_on glp2_on
20.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
20.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
20.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
20.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
20.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
20.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
20.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
20.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
20.00Single7F8ULintitript7F8U-CCKA-Lintitript
20.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
20.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
20.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
20.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
20.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.00Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
20.00Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.44Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
19.44Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
19.44Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.44Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
19.35Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
19.35Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
19.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
19.35Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
19.35Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Consensusclass-d_onOrthosteric Ligandste2_on
19.35Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
19.23Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
19.23Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single5IU7Q274563465IU7-A2A-Q27456346-Na
19.05Single5JTBZM2413855JTB-A2A-ZM241385
19.05Single5K2BZM2413855K2B-A2A-ZM241385-Na
19.05Single6AQFZM2413856AQF-A2A-ZM241385
19.05Single6FFIMMPEP6FFI-mGlu5-MMPEP
19.05Single6MH8ZM2413856MH8-A2A-ZM241385
19.05Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
19.05Single7AROLUF58337ARO-A2A-LUF5833-Na
19.05Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
19.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
19.05Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
19.05Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
19.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
19.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
19.05Single8K2WAMG4878K2W-CXCR3-AMG487
18.75Single5MZPCaffeine5MZP-A2A-Caffeine-Na
18.75Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
18.75Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.75Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
18.75Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
18.75Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
18.75Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.75Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
18.75Consensusgi_class-dOrthosteric Ligandgi_ste
18.75Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.75Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.52Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
18.52Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.52Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
18.52Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
18.18Single3EMLZM2413853EML-A2A-ZM241385
18.18Single4EIYZM2413854EIY-A2A-ZM241385-Na
18.18Single5IU8Q274563475IU8-A2A-Q27456347-Na
18.18Single5K2AZM2413855K2A-A2A-ZM241385-Na
18.18Single5OLGZM2413855OLG-A2A-ZM241385-Na
18.18Single5UENDU1725UEN-A1-DU172
18.18Single5VRAZM2413855VRA-A2A-ZM241385-Na
18.18Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
18.18Single6FFHFenobam6FFH-mGlu5-Fenobam
18.18Single6LMLGlucagon6LML-Glucagon-Glucagon
18.18Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.18Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
18.18Single6S0LZM2413856S0L-A2A-ZM241385
18.18Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
18.18Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.18Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
18.18Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
18.18Single7PYRPSB-21157PYR-A2A-PSB-2115
18.18Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
18.18Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
18.18Consensusa2_offOrthosteric Liganda2a_off
18.18Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
18.18Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
18.18Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
18.18Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
18.18Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
18.18Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.86Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensussst_offOrthosteric Ligandsst2_off
17.65Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
17.65Single7WC4Serotonin7WC4-5-HT2A-Serotonin
17.65Single8PWNTheophylline8PWN-A2A-Theophylline
17.65Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
17.50Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
17.39Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
17.39Single5IUAQ274563485IUA-A2A-Q27456348-Na
17.39Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
17.39Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
17.39Single6LPLZM2413856LPL-A2A-ZM241385-Na
17.39Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
17.39Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.39Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
17.39Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
17.39Single6S0QZM2413856S0Q-A2A-ZM241385
17.39Single6WQAZM2413856WQA-A2A-ZM241385-Na
17.39Single7RM5ZM2413857RM5-A2A-ZM241385-Na
17.39Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8FYNZM2413858FYN-A2A-ZM241385-Na
17.39Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
17.39Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
17.39Single8QOTNanobody E8QOT-μ-Nanobody E
17.39Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
17.39Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
17.39Consensusep_offOrthosteric Ligandep4_off
17.39Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.24Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single7XNACYN1548067XNA-SST2-CYN154806
17.24Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
17.14Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.14Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.67Single3RFMCaffeine3RFM-A2A-Caffeine
16.67Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
16.67Single5TZR-5TZR-FFA1 (GPR40)-MK8666
16.67Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.67Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
16.67Single6OS1TRV0266OS1-AT1-TRV026
16.67Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
16.67Single7P2L4YI7P2L-mGlu5-4YI
16.67Single7PX4PSB-21137PX4-A2A-PSB-2113
16.67Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
16.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
16.67Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
16.67Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.67Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
16.67Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.67Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
16.67Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
16.67Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
16.67Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
16.67Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.22Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
16.13Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
16.13Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
16.13Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.00Single4N4WSANT-14N4W-SMO-SANT-1
16.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
16.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
16.00Consensuschemokine_offOrthosteric Ligandcxcr_off
16.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
16.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
16.00Consensuscxcr_offOrthosteric Ligandcxcr4_off
16.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
16.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
15.79Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
15.79Single7WC5Psilocin7WC5-5-HT2A-Psilocin
15.79Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
15.79Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.79Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
15.79Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.79Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
15.62Single6FJ3PTH6FJ3-PTH1-PTH
15.62Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.62Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
15.38Single4BUONeurotensin4BUO-NTS1-Neurotensin
15.38Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
15.38Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
15.15Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.15Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.15Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
15.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
15.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
15.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
15.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
15.00Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
15.00Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
15.00Consensusgo_class-b2Orthosteric Ligandgo_adhesion
15.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.81Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
14.81Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
14.81Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
14.81Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
14.71Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
14.71Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.71Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single3PWHZM2413853PWH-A2A-ZM241385
14.29Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
14.29Single5K2DZM2413855K2D-A2A-ZM241385
14.29Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
14.29Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
14.29Single5ZKQABT-4915ZKQ-PAF-ABT-491
14.29Single6JZHZM2413856JZH-A2A-ZM241385-Na
14.29Single6PS7ZM2413856PS7-A2A-ZM241385-Na
14.29Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
14.29Single7BR3Elagolix7BR3-GnRH1-Elagolix
14.29Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
14.29Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
14.29Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
14.29Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
14.29Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
14.29Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
14.29Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
14.29Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.29Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
14.29Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
14.29Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.89Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
13.79Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
13.79Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single3REYPubChem 56973REY-A2A-PubChem 5697
13.64Single5IU4ZM2413855IU4-A2A-ZM241385-Na
13.64Single5IUBQ274563445IUB-A2A-Q27456344-Na
13.64Single5K2CZM2413855K2C-A2A-ZM241385-Na
13.64Single5NLXZM2413855NLX-A2A-ZM241385-Na
13.64Single5NM4ZM2413855NM4-A2A-ZM241385-Na
13.64Single5UVIZM2413855UVI-A2A-ZM241385
13.64Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.64Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
13.64Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
13.64Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
13.64Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
13.64Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
13.64Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
13.64Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
13.64Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
13.64Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
13.64Consensusgnrh_offOrthosteric Ligandgnrh1_off
13.64Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
13.64Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
13.51Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
13.33Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
13.33Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
13.33Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
13.04Single5T04Neurotensin5T04-NTS1-Neurotensin
13.04Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.04Single6LPJZM2413856LPJ-A2A-ZM241385-Na
13.04Single6LPKZM2413856LPK-A2A-ZM241385-Na
13.04Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.04Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
13.04Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
13.04Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.04Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.04Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
13.04Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.04Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.04Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
12.90Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.82Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.50Single4NTJAZD12834NTJ-P2Y12-AZD1283
12.50Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
12.50Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
12.50Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
12.50Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
12.12Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.12Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
12.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
12.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
12.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
12.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
11.90Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
11.76Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
11.76Single6W25Ca6W25-MC4-SHU9119-Ca
11.76Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
11.54Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
11.54Single4PY02MeSATP4PY0-P2Y12-2MeSATP
11.54Single4XEENeurotensin4XEE-NTS1-Neurotensin
11.54Single4XESNeurotensin4XES-NTS1-Neurotensin
11.54Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
11.54Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
11.54Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
11.54Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
11.54Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
11.54Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
11.54Consensusnts_offOrthosteric Ligandnts1_off
11.54Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
11.43Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
11.43Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
11.11Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
11.11Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.11Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
11.11Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
11.11Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.11Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single6KNMJN241-96KNM-Apelin-JN241-9
10.71Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
10.71Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
10.71Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
10.71Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusgs_class-b2Orthosteric Ligandgs_adgr
10.53Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
10.53Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
10.53Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.34Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
10.34Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
10.26Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
10.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
10.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
10.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
9.76Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.52Single5L7IVismodegib5L7I-SMO-Vismodegib
9.52Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
9.52Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
9.52Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
9.52Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
9.52Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
9.52Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
9.52Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.38Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
9.38Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.09Single5U09Taranabant5U09-CB1-Taranabant
9.09Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.09Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
9.09Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.09Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
9.09Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
8.82Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
8.82Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
8.70Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
8.70Single6ZINSR486926ZIN-NTS1-SR48692
8.70Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
8.70Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
8.57Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
8.33Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
8.33Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
8.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
8.33Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
8.33Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
8.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.00Single6Z4SSR486926Z4S-NTS1-SR48692
8.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.41Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
7.41Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
7.41Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
7.41Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.41Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
7.41Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.41Consensusnts_onOrthosteric Ligandnts1_on
7.14Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
7.14Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
7.14Consensuscyslt_offOrthosteric Ligandcyslt2_off
7.14Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.90Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
6.90Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
6.67Consensusclass-c_offOther Ligandgabab_off mglu_off
6.45Single7SHEPI; PE7SHE-GPR158-PI; PE
6.45Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single8HS2Fab0468HS2-GPR20-Fab046
5.41Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.26Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
5.26Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.26Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.26Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.26Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
5.26Consensusclass-c_onOther Ligandgabab_on mglu_on
5.13Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.00Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
5.00Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.00Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.88Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
4.88Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
4.76Single6LI0GTPL98046LI0-GPR52-GTPL9804
4.76Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
4.76Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
4.76Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.76Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.65Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.44Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.35Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.35Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.35Single4QINSAG1.54QIN-SMO-SAG1.5
4.35Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.35Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.35Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
4.35Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
4.35Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
4.35Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
4.35Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.35Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.35Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
4.35Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.17Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.17Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.17Single8IYXYL-3658IYX-GPR34-YL-365
4.17Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.17Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
4.17Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.17Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
4.00Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
3.85Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
3.85Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
3.85Single8GTGBMK-I1528GTG-CRF1-BMK-I152
3.70Single5V56TC1145V56-SMO-TC114
3.70Single5V57TC1145V57-SMO-TC114
3.70Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
3.70Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57Single7SHEPI; PE7SHE-GPR158-PI; PE
3.57Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.45Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.23Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
3.12Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.56Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.56Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2

PDB Summary
PDB 5UNH
Class A
SubFamily Peptide
Type Angiotensin
SubType AT2
Species Homo sapiens
Ligand PubChem 126456406
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.9
Date 2017-04-05
D.O.I. 10.1038/nature22035
Net Summary
Imin 2.85
Number of Linked Nodes 259
Number of Links 293
Number of Hubs 39
Number of Links mediated by Hubs 150
Number of Communities 9
Number of Nodes involved in Communities 56
Number of Links involved in Communities 75
Path Summary
Number Of Nodes in MetaPath 85
Number Of Links MetaPath 84
Number of Shortest Paths 44072
Length Of Smallest Path 3
Average Path Length 11.9674
Length of Longest Path 31
Minimum Path Strength 1.36
Average Path Strength 5.91605
Maximum Path Strength 20.13
Minimum Path Correlation 0.7
Average Path Correlation 0.919804
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 54.0468
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.5122
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code8EM
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code8EM
NameN-[(furan-2-yl)methyl]-N-(4-oxo-2-propyl-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide
Synonyms
Identifier~{N}-(furan-2-ylmethyl)-~{N}-[4-oxidanylidene-2-propyl-3-[[4-[2-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-6-yl]benzamide
FormulaC37 H31 N7 O3
Molecular Weight621.687
SMILESCCCC1=Nc2ccc(cc2C(=O)N1Cc3ccc(cc3)c4ccccc4c5n[nH]nn5)N(Cc6ccco6)C(=O)c7ccccc7
PubChem126456406
Formal Charge0
Total Atoms78
Total Chiral Atoms0
Total Bonds84
Total Aromatic Bonds34

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP50052
Sequence
>5UNH_Chain_R
LDAIPILYY IIFVIGFLV NIVVVTLFC KVSSIYIFN LAVADLLLL 
ATLPLWATY YSYRYDWLF GPVMCKVFG SFLTLNMFA SIFFITCMS 
VDRYQSVIY PFASYIVPL VWCMACLSS LPTFYFRDV RTIEYLGVN 
ACIMAFPPY AQWSAGIAL MKNILGFII PLIFIATCY FGIRKHLLK 
TNSYGKNRI TRDQVLKMA AAVVLAFII CWLPFHVLT FLDALAWMG 
VINSCEVIA VIDLALPFA ILLGFTNSC VNPFLYCFV GNRFQQKLR 
SV


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ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5UNFAPeptideAngiotensinAT2Homo sapiensPubChem 15780052--2.82017-04-0510.1038/nature22035
5UNGAPeptideAngiotensinAT2Homo sapiensPubChem 15780052--2.82017-04-0510.1038/nature22035
5XJMAPeptideAngiotensinAT2Homo sapiens(Sar1,Ile8)-Angiotensin II--3.22018-07-1110.1038/s41594-018-0079-8
6JODAPeptideAngiotensinAT2Homo sapiensAngiotensin II--3.22020-01-1510.1016/j.str.2019.12.003
7C6AAPeptideAngiotensinAT2Homo sapiens(Sar1,Ile8)-Angiotensin II--3.42020-07-2910.1038/s41598-020-68355-x
7JNIAPeptideAngiotensinAT2Homo sapiensOlodanrigan--32022-02-0910.1073/pnas.2116289119




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