psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:D9	A:A:L5	5.43	No	No	0	4	2
2	A:A:D9	A:A:S6	8.83	No	No	0	4	7
3	A:A:V13	B:B:N88	5.91	No	Yes	0	3	7
4	A:A:R15	B:B:H91	3.39	No	Yes	0	5	5
5	A:A:S16	B:B:N88	7.45	No	Yes	0	7	7
6	A:A:S16	B:B:K89	3.06	No	Yes	0	7	9
7	A:A:I19	A:A:L23	2.85	No	No	5	9	6
8	A:A:I19	B:B:K89	7.27	No	Yes	5	9	9
9	A:A:D20	A:A:R24	3.57	No	No	0	6	3
10	A:A:D20	B:B:K89	8.3	No	Yes	0	6	9
11	A:A:L23	B:B:K78	7.05	No	Yes	5	6	8
12	A:A:L23	B:B:K89	2.82	No	Yes	5	6	9
13	A:A:D26	B:B:K78	8.3	No	Yes	0	5	8
14	A:A:A31	R:R:H152	2.93	No	No	0	4	7
15	A:A:E33	A:A:H188	8.62	No	No	17	6	3
16	A:A:E33	A:A:H195	6.15	No	No	17	6	4
17	A:A:E33	A:A:K197	9.45	No	No	17	6	6
18	A:A:L36	A:A:V34	2.98	No	Yes	0	7	5
19	A:A:L194	A:A:V34	2.98	No	Yes	11	4	5
20	A:A:F196	A:A:V34	11.8	Yes	Yes	11	7	5
21	A:A:T219	A:A:V34	4.76	No	Yes	11	7	5
22	A:A:V339	A:A:V34	8.02	No	Yes	11	8	5
23	A:A:V34	R:R:L151	2.98	Yes	Yes	11	5	4
24	A:A:F199	A:A:K35	6.2	Yes	No	0	5	9
25	A:A:K35	A:A:V218	3.04	No	No	0	9	9
26	A:A:L36	A:A:M198	2.83	No	Yes	0	7	7
27	A:A:I222	A:A:L36	7.14	No	No	0	7	7
28	A:A:L37	A:A:L39	5.54	No	No	0	9	9
29	A:A:L37	A:A:V201	4.47	No	Yes	1	9	9
30	A:A:F215	A:A:L37	8.53	Yes	No	1	9	9
31	A:A:K46	A:A:L38	2.82	Yes	No	0	9	8
32	A:A:L38	A:A:M198	5.65	No	Yes	0	8	7
33	A:A:I222	A:A:L38	5.71	No	No	0	7	8
34	A:A:I253	A:A:L39	8.56	No	No	0	8	9
35	A:A:F223	A:A:G40	4.52	Yes	No	0	9	9
36	A:A:K46	A:A:S44	3.06	Yes	No	22	9	9
37	A:A:C224	A:A:S44	3.44	No	No	22	7	9
38	A:A:D200	A:A:K46	5.53	No	Yes	0	9	9
39	A:A:C224	A:A:K46	3.23	No	Yes	22	7	9
40	A:A:Q52	A:A:T48	2.83	No	No	0	9	9
41	A:A:N269	A:A:T48	2.92	No	No	0	9	9
42	A:A:S326	A:A:T48	7.99	No	No	0	9	9
43	A:A:C224	A:A:I49	6.55	No	No	0	7	7
44	A:A:I49	A:A:N269	4.25	No	No	0	7	9
45	A:A:M198	A:A:V50	3.04	Yes	No	0	7	6
46	A:A:K51	A:A:K54	4.31	No	No	0	9	7
47	A:A:N331	A:A:Q52	13.2	No	No	0	8	9
48	A:A:I55	A:A:M53	5.83	No	No	0	8	8
49	A:A:F189	A:A:M53	4.98	Yes	No	0	9	8
50	A:A:G183	A:A:T182	5.46	No	No	1	9	7
51	A:A:T182	B:B:N119	5.85	No	Yes	1	7	9
52	A:A:G183	B:B:N119	5.09	No	Yes	1	9	9
53	A:A:F199	A:A:I184	3.77	Yes	Yes	1	5	9
54	A:A:I184	A:A:V201	3.07	Yes	Yes	1	9	9
55	A:A:I184	B:B:W99	8.22	Yes	Yes	1	9	9
56	A:A:I184	B:B:L117	4.28	Yes	Yes	1	9	9
57	A:A:E186	A:A:K197	8.1	No	No	0	9	6
58	A:A:E186	A:A:F199	12.83	No	Yes	0	9	5
59	A:A:M198	A:A:T187	4.52	Yes	No	0	7	6
60	A:A:H188	A:A:H195	9.55	No	No	17	3	4
61	A:A:H188	A:A:K197	9.17	No	No	17	3	6
62	A:A:F189	A:A:F196	15	Yes	Yes	0	9	7
63	A:A:F189	A:A:M198	7.46	Yes	Yes	0	9	7
64	A:A:F189	A:A:V332	2.62	Yes	No	0	9	7
65	A:A:H195	A:A:T190	9.58	No	No	0	4	3
66	A:A:F191	A:A:K192	11.17	Yes	No	23	5	4
67	A:A:F191	A:A:V332	5.24	Yes	No	0	5	7
68	A:A:F191	A:A:Q333	3.51	Yes	Yes	23	5	5
69	A:A:F191	A:A:F336	8.57	Yes	Yes	0	5	8
70	A:A:K192	A:A:Q333	4.07	No	Yes	23	4	5
71	A:A:F196	A:A:L194	4.87	Yes	No	11	7	4
72	A:A:F336	A:A:L194	6.09	Yes	No	0	8	4
73	A:A:F196	A:A:V335	2.62	Yes	No	0	7	8
74	A:A:F196	A:A:V339	3.93	Yes	No	11	7	8
75	A:A:F199	A:A:F215	4.29	Yes	Yes	1	5	9
76	A:A:F199	B:B:W99	18.04	Yes	Yes	1	5	9
77	A:A:V201	A:A:W211	6.13	Yes	Yes	1	9	9
78	A:A:F215	A:A:V201	3.93	Yes	Yes	1	9	9
79	A:A:Q204	A:A:W211	4.38	Yes	Yes	1	9	9
80	A:A:Q204	B:B:L117	5.32	Yes	Yes	1	9	9
81	A:A:Q204	B:B:N119	2.64	Yes	Yes	1	9	9
82	A:A:Q204	B:B:Y145	5.64	Yes	Yes	1	9	8
83	A:A:S206	B:B:Y145	5.09	No	Yes	1	8	8
84	A:A:S206	B:B:D186	7.36	No	Yes	1	8	9
85	A:A:E207	A:A:K209	6.75	Yes	No	0	9	8
86	A:A:E207	A:A:K210	2.7	Yes	Yes	1	9	9
87	A:A:E207	B:B:D186	5.2	Yes	Yes	1	9	9
88	A:A:E207	B:B:C204	4.56	Yes	Yes	1	9	7
89	A:A:R208	A:A:W211	4	Yes	Yes	1	9	9
90	A:A:I212	A:A:R208	5.01	Yes	Yes	1	8	9
91	A:A:L249	A:A:R208	4.86	No	Yes	0	9	9
92	A:A:R208	A:A:S252	6.59	Yes	No	0	9	7
93	A:A:K209	B:B:D228	4.15	No	Yes	0	8	9
94	A:A:K210	B:B:Y145	3.58	Yes	Yes	1	9	8
95	A:A:K210	B:B:M188	14.4	Yes	No	1	9	8
96	A:A:K210	B:B:C204	4.85	Yes	Yes	1	9	7
97	A:A:K210	B:B:D228	6.91	Yes	Yes	1	9	9
98	A:A:K210	B:B:N230	6.99	Yes	No	1	9	9
99	A:A:I212	A:A:W211	3.52	Yes	Yes	1	8	9
100	A:A:F215	A:A:W211	4.01	Yes	Yes	1	9	9
101	A:A:W211	B:B:Y145	2.89	Yes	Yes	1	9	8
102	A:A:I212	A:A:N256	4.25	Yes	No	1	8	8
103	A:A:F259	A:A:I212	5.02	No	Yes	1	9	8
104	A:A:C214	A:A:H213	2.95	Yes	Yes	1	7	8
105	A:A:H213	A:A:W258	8.46	Yes	Yes	1	8	5
106	A:A:H213	B:B:Y59	7.62	Yes	Yes	1	8	8
107	A:A:H213	B:B:W332	8.46	Yes	Yes	1	8	9
108	A:A:C214	A:A:F215	2.79	Yes	Yes	1	7	9
109	A:A:C214	B:B:Y59	5.38	Yes	Yes	1	7	8
110	A:A:C214	B:B:Q75	9.16	Yes	No	1	7	9
111	A:A:F215	A:A:V218	2.62	Yes	No	0	9	9
112	A:A:F215	B:B:W99	9.02	Yes	Yes	1	9	9
113	A:A:E216	A:A:W258	6.54	No	Yes	0	7	5
114	A:A:E216	B:B:K57	9.45	No	No	0	7	9
115	A:A:T219	R:R:L151	2.95	No	Yes	11	7	4
116	A:A:A220	A:A:I265	3.25	No	Yes	0	8	8
117	A:A:F259	A:A:I221	8.79	No	No	0	9	8
118	A:A:I221	A:A:T262	3.04	No	No	0	8	7
119	A:A:I222	A:A:I265	2.94	No	Yes	0	7	8
120	A:A:F223	A:A:V225	2.62	Yes	Yes	0	9	7
121	A:A:F223	A:A:L249	4.87	Yes	No	0	9	9
122	A:A:F223	A:A:F250	13.93	Yes	Yes	0	9	9
123	A:A:F223	A:A:L266	3.65	Yes	Yes	0	9	9
124	A:A:M243	A:A:V225	3.04	Yes	Yes	0	8	7
125	A:A:S246	A:A:V225	6.46	No	Yes	0	9	7
126	A:A:L268	A:A:V225	4.47	Yes	Yes	0	8	7
127	A:A:F307	A:A:V225	7.87	Yes	Yes	0	8	7
128	A:A:A226	A:A:D229	6.18	No	Yes	0	8	8
129	A:A:L227	A:A:L268	5.54	No	Yes	0	7	8
130	A:A:F274	A:A:L227	7.31	Yes	No	0	9	7
131	A:A:I303	A:A:L227	4.28	No	No	0	7	7
132	A:A:D229	A:A:S228	4.42	Yes	Yes	7	8	9
133	A:A:K270	A:A:S228	9.18	No	Yes	7	9	9
134	A:A:L273	A:A:S228	6.01	No	Yes	7	6	9
135	A:A:K277	A:A:S228	3.06	No	Yes	7	9	9
136	A:A:D229	A:A:L232	5.43	Yes	No	7	8	8
137	A:A:D229	A:A:R242	11.91	Yes	No	7	8	9
138	A:A:D231	A:A:Y230	13.79	Yes	Yes	7	9	8
139	A:A:F274	A:A:Y230	6.19	Yes	Yes	0	9	8
140	A:A:K277	A:A:Y230	4.78	No	Yes	7	9	8
141	A:A:L283	A:A:Y230	4.69	No	Yes	0	7	8
142	A:A:D231	A:A:L232	5.43	Yes	No	7	9	8
143	A:A:D231	A:A:K277	13.83	Yes	No	7	9	9
144	A:A:D231	A:A:S281	4.42	Yes	No	0	9	7
145	A:A:L232	A:A:R242	3.64	No	No	7	8	9
146	A:A:M240	A:A:V233	4.56	No	No	0	6	5
147	A:A:L234	A:A:R242	7.29	No	No	0	8	9
148	A:A:M243	A:A:N241	4.21	Yes	No	6	8	9
149	A:A:H244	A:A:N241	16.58	No	No	6	4	9
150	A:A:C286	A:A:N241	3.15	Yes	No	6	6	9
151	A:A:C286	A:A:M243	3.24	Yes	Yes	6	6	8
152	A:A:I303	A:A:M243	2.92	No	Yes	0	7	8
153	A:A:C286	A:A:H244	2.95	Yes	No	6	6	4
154	A:A:E245	A:A:K248	8.1	No	No	0	9	5
155	A:A:M247	A:A:Y287	7.18	No	Yes	0	6	7
156	A:A:F307	A:A:M247	4.98	Yes	No	0	8	6
157	A:A:L310	A:A:M247	7.07	No	No	0	4	6
158	A:A:I253	A:A:L249	7.14	No	No	0	8	9
159	A:A:C254	A:A:F250	6.98	Yes	Yes	8	5	9
160	A:A:F250	A:A:I264	5.02	Yes	No	8	9	6
161	A:A:F250	A:A:F307	6.43	Yes	Yes	0	9	8
162	A:A:F250	A:A:L310	3.65	Yes	No	0	9	4
163	A:A:F250	A:A:I319	5.02	Yes	No	0	9	5
164	A:A:D251	A:A:N255	4.04	No	Yes	8	5	8
165	A:A:D251	A:A:L310	4.07	No	No	0	5	4
166	A:A:D251	A:A:K312	6.91	No	No	8	5	5
167	A:A:C254	A:A:N255	4.72	Yes	Yes	8	5	8
168	A:A:C254	A:A:I264	3.27	Yes	No	8	5	6
169	A:A:C254	A:A:N311	6.3	Yes	Yes	8	5	8
170	A:A:C254	A:A:K317	6.47	Yes	No	8	5	7
171	A:A:K312	A:A:N255	15.39	No	Yes	8	5	8
172	A:A:N255	A:A:R313	3.62	Yes	No	0	8	4
173	A:A:N256	A:A:W258	3.39	No	Yes	1	8	5
174	A:A:F259	A:A:N256	3.62	No	No	1	9	8
175	A:A:K257	A:A:W258	13.92	No	Yes	0	4	5
176	A:A:W258	B:B:W332	3.75	Yes	Yes	1	5	9
177	A:A:D261	A:A:T260	2.89	No	No	0	4	3
178	A:A:R313	A:A:T260	6.47	No	No	0	4	3
179	A:A:D261	A:A:T316	2.89	No	No	0	4	3
180	A:A:S263	A:A:Y320	3.82	No	Yes	13	7	7
181	A:A:S263	A:A:V342	6.46	No	No	13	7	7
182	A:A:I264	A:A:K317	4.36	No	No	8	6	7
183	A:A:F267	A:A:I265	3.77	Yes	Yes	0	9	8
184	A:A:A338	A:A:I265	3.25	No	Yes	0	6	8
185	A:A:L266	A:A:L268	5.54	Yes	Yes	12	9	8
186	A:A:F307	A:A:L266	3.65	Yes	Yes	0	8	9
187	A:A:I319	A:A:L266	2.85	No	Yes	0	5	9
188	A:A:L266	A:A:T321	5.9	Yes	Yes	12	9	5
189	A:A:F267	A:A:H322	6.79	Yes	No	18	9	9
190	A:A:F267	A:A:T324	7.78	Yes	Yes	18	9	9
191	A:A:F267	A:A:N331	4.83	Yes	No	18	9	8
192	A:A:F267	A:A:V335	2.62	Yes	No	0	9	8
193	A:A:L268	A:A:T321	2.95	Yes	Yes	12	8	5
194	A:A:F323	A:A:L268	8.53	No	Yes	0	4	8
195	A:A:N269	A:A:T324	7.31	No	Yes	0	9	9
196	A:A:K270	A:A:L273	2.82	No	No	7	9	6
197	A:A:K271	A:A:Y296	5.97	No	Yes	0	5	4
198	A:A:C325	A:A:K271	4.85	No	No	0	7	5
199	A:A:D272	A:A:L273	6.79	No	No	0	9	6
200	A:A:F274	A:A:Y296	4.13	Yes	Yes	0	9	4
201	A:A:E275	A:A:K279	8.1	No	No	0	5	2
202	A:A:E275	A:A:Y296	10.1	No	Yes	0	5	4
203	A:A:K279	A:A:K280	4.31	No	No	0	2	1
204	A:A:P282	A:A:S281	5.34	Yes	No	0	5	7
205	A:A:I285	A:A:P282	5.08	No	Yes	0	3	5
206	A:A:L283	A:A:Y290	8.21	No	Yes	0	7	7
207	A:A:I303	A:A:L283	2.85	No	No	0	7	7
208	A:A:C286	A:A:Y287	13.44	Yes	Yes	6	6	7
209	A:A:E289	A:A:Y287	6.73	No	Yes	6	6	7
210	A:A:Y287	A:A:Y302	4.96	Yes	Yes	6	7	6
211	A:A:Q306	A:A:Y287	14.65	No	Yes	6	5	7
212	A:A:E289	A:A:P288	4.72	No	No	0	6	5
213	A:A:E289	A:A:Y302	3.37	No	Yes	6	6	6
214	A:A:G292	A:A:Y290	7.24	No	Yes	6	7	7
215	A:A:E298	A:A:Y290	4.49	Yes	Yes	6	4	7
216	A:A:Y290	A:A:Y302	17.87	Yes	Yes	6	7	6
217	A:A:E298	A:A:G292	3.27	Yes	No	6	4	7
218	A:A:S293	A:A:T295	3.2	No	No	6	3	5
219	A:A:E298	A:A:S293	8.62	Yes	No	6	4	3
220	A:A:E298	A:A:T295	4.23	Yes	No	6	4	5
221	A:A:A300	A:A:F323	4.16	No	No	0	5	4
222	A:A:Q306	A:A:Y302	13.53	No	Yes	6	5	6
223	A:A:E308	A:A:Q304	7.65	No	Yes	12	3	5
224	A:A:Q304	A:A:T321	17.01	Yes	Yes	12	5	5
225	A:A:F323	A:A:Q304	5.86	No	Yes	0	4	5
226	A:A:Q304	R:R:K239	2.71	Yes	No	12	5	2
227	A:A:E308	A:A:T321	5.64	No	Yes	12	3	5
228	A:A:E308	R:R:K239	2.7	No	No	12	3	2
229	A:A:K314	A:A:N311	2.8	No	Yes	0	3	8
230	A:A:K317	A:A:N311	5.6	No	Yes	8	7	8
231	A:A:I319	A:A:N311	5.66	No	Yes	0	5	8
232	A:A:E318	A:A:Y320	10.1	No	Yes	0	4	7
233	A:A:A338	A:A:Y320	6.67	No	Yes	0	6	7
234	A:A:D341	A:A:Y320	12.64	Yes	Yes	13	8	7
235	A:A:V342	A:A:Y320	3.79	No	Yes	13	7	7
236	A:A:Y320	R:R:F237	5.16	Yes	Yes	13	7	3
237	A:A:H322	A:A:T324	2.74	No	Yes	18	9	9
238	A:A:F334	A:A:H322	24.89	No	No	0	3	9
239	A:A:N331	A:A:T324	10.24	No	Yes	18	8	9
240	A:A:C325	A:A:T327	6.76	No	No	0	7	8
241	A:A:D328	A:A:T329	2.89	No	No	0	9	9
242	A:A:D337	A:A:Q333	7.83	Yes	Yes	0	4	5
243	A:A:F334	R:R:F237	3.22	No	Yes	0	3	3
244	A:A:D337	A:A:F336	3.58	Yes	Yes	0	4	8
245	A:A:F336	A:A:T340	7.78	Yes	No	0	8	6
246	A:A:D337	R:R:L235	4.07	Yes	Yes	0	4	6
247	A:A:D337	R:R:T236	2.89	Yes	No	0	4	4
248	A:A:I343	A:A:V339	3.07	No	No	0	7	8
249	A:A:T340	R:R:L235	2.95	No	Yes	0	6	6
250	A:A:D341	A:A:K345	9.68	Yes	No	0	8	5
251	A:A:D341	R:R:L235	2.71	Yes	Yes	13	8	6
252	A:A:D341	R:R:F237	7.17	Yes	Yes	13	8	3
253	A:A:N346	A:A:V342	4.43	No	No	0	4	7
254	A:A:I343	R:R:M149	2.92	No	Yes	0	7	8
255	A:A:I343	R:R:L151	5.71	No	Yes	0	7	4
256	A:A:F354	A:A:K345	3.72	No	No	0	5	5
257	A:A:K349	A:A:N346	4.2	No	No	0	5	4
258	A:A:N347	R:R:M149	4.21	No	Yes	0	8	8
259	A:A:L348	A:A:L353	2.77	Yes	Yes	9	9	7
260	A:A:F354	A:A:L348	4.87	No	Yes	0	5	9
261	A:A:L348	R:R:M146	5.65	Yes	No	0	9	8
262	A:A:L348	R:R:L254	2.77	Yes	Yes	9	9	8
263	A:A:F354	A:A:K349	8.69	No	No	0	5	5
264	A:A:D350	R:R:M80	2.77	No	No	0	4	8
265	A:A:D350	R:R:K150	5.53	No	No	19	4	7
266	A:A:D350	R:R:N153	10.77	No	No	19	4	4
267	A:A:C351	R:R:R142	4.18	No	Yes	0	4	9
268	A:A:C351	R:R:T145	8.45	No	No	0	4	8
269	A:A:C351	R:R:M146	3.24	No	No	0	4	8
270	A:A:G352	R:R:N315	5.09	No	Yes	0	8	8
271	A:A:L353	R:R:R142	9.72	Yes	Yes	9	7	9
272	A:A:L353	R:R:L254	4.15	Yes	Yes	9	7	8
273	A:A:L353	R:R:T257	2.95	Yes	No	0	7	9
274	B:B:L4	B:B:R8	4.86	No	No	0	4	3
275	B:B:D5	B:B:Q6	5.22	No	No	0	1	1
276	B:B:L7	B:B:Q6	3.99	Yes	No	0	8	1
277	B:B:L7	G:G:A12	4.73	Yes	No	0	8	5
278	B:B:E10	G:G:V16	9.98	No	Yes	20	8	7
279	B:B:E10	G:G:K20	4.05	No	Yes	20	8	6
280	B:B:E12	B:B:K15	5.4	No	No	0	4	6
281	B:B:L14	B:B:Q17	3.99	No	No	0	8	4
282	B:B:L14	G:G:L19	4.15	No	No	0	8	9
283	B:B:L14	G:G:K20	2.82	No	Yes	0	8	6
284	B:B:K15	G:G:L19	2.82	No	No	0	6	9
285	B:B:Q17	G:G:A23	3.03	No	No	0	4	8
286	B:B:I18	B:B:R22	6.26	Yes	No	1	7	6
287	B:B:I18	G:G:E22	2.73	Yes	No	0	7	9
288	B:B:I18	G:G:A23	3.25	Yes	No	0	7	8
289	B:B:I18	G:G:R27	3.76	Yes	Yes	1	7	8
290	B:B:A21	G:G:R27	4.15	No	Yes	0	4	8
291	B:B:D258	B:B:R22	11.91	Yes	No	1	7	6
292	B:B:R22	G:G:R27	3.2	No	Yes	1	6	8
293	B:B:C25	B:B:Q259	4.58	No	No	0	3	6
294	B:B:C25	G:G:R27	2.79	No	Yes	0	3	8
295	B:B:A26	B:B:Q259	4.55	No	No	0	3	6
296	B:B:D27	G:G:K29	6.91	No	No	0	8	4
297	B:B:D27	G:G:S31	8.83	No	No	0	8	9
298	B:B:Q32	B:B:T29	5.67	No	No	0	1	3
299	B:B:L30	B:B:T34	7.37	Yes	Yes	0	5	5
300	B:B:L261	B:B:L30	2.77	No	Yes	0	5	5
301	B:B:L30	B:B:M262	5.65	Yes	Yes	0	5	4
302	B:B:L30	G:G:A34	4.73	Yes	No	0	5	6
303	B:B:M262	B:B:S31	3.07	Yes	No	0	4	1
304	B:B:I37	B:B:T34	4.56	Yes	Yes	1	2	5
305	B:B:L300	B:B:T34	4.42	Yes	Yes	1	6	5
306	B:B:T34	G:G:M38	3.01	Yes	No	1	5	4
307	B:B:I37	B:B:R283	3.76	Yes	Yes	1	2	9
308	B:B:I37	B:B:L300	2.85	Yes	Yes	1	2	6
309	B:B:I37	G:G:M38	4.37	Yes	No	1	2	4
310	B:B:K301	B:B:P39	5.02	No	No	0	5	1
311	B:B:I43	B:B:V40	3.07	Yes	Yes	1	3	3
312	B:B:R283	B:B:V40	7.85	Yes	Yes	1	9	3
313	B:B:D298	B:B:V40	7.3	Yes	Yes	1	9	3
314	B:B:R304	B:B:V40	2.62	Yes	Yes	1	5	3
315	B:B:V40	G:G:L51	2.98	Yes	Yes	1	3	6
316	B:B:Q44	B:B:R42	4.67	No	No	0	4	2
317	B:B:R304	B:B:R42	5.33	Yes	No	0	5	2
318	B:B:I43	B:B:M45	4.37	Yes	Yes	1	3	4
319	B:B:I43	B:B:L284	2.85	Yes	No	0	3	5
320	B:B:I43	B:B:R304	6.26	Yes	Yes	1	3	5
321	B:B:L308	B:B:M45	7.07	Yes	Yes	1	7	4
322	B:B:M45	B:B:W339	3.49	Yes	Yes	1	4	9
323	B:B:M45	B:B:N340	2.8	Yes	Yes	0	4	9
324	B:B:M45	G:G:L50	5.65	Yes	Yes	1	4	9
325	B:B:R46	B:B:R48	7.46	No	No	0	5	7
326	B:B:T47	B:B:T50	3.14	No	No	1	3	3
327	B:B:K337	B:B:T47	4.5	Yes	No	1	6	3
328	B:B:T47	B:B:W339	7.28	No	Yes	1	3	9
329	B:B:N340	B:B:R48	13.26	Yes	No	0	9	7
330	B:B:I338	B:B:R49	5.01	No	No	5	5	7
331	B:B:R49	G:G:F61	5.34	No	Yes	5	7	8
332	B:B:R52	B:B:T50	10.35	No	No	0	7	3
333	B:B:K337	B:B:T50	10.51	Yes	No	1	6	3
334	B:B:L51	B:B:W82	15.94	Yes	Yes	5	9	9
335	B:B:L51	B:B:T87	2.95	Yes	No	0	9	5
336	B:B:L336	B:B:L51	6.92	Yes	Yes	5	7	9
337	B:B:I338	B:B:L51	4.28	No	Yes	5	5	9
338	B:B:F335	B:B:R52	6.41	No	No	0	4	7
339	B:B:G53	B:B:K89	3.49	No	Yes	0	9	9
340	B:B:H54	B:B:I58	10.61	Yes	No	5	9	9
341	B:B:H54	B:B:S72	8.37	Yes	No	5	9	9
342	B:B:H54	B:B:S74	16.74	Yes	No	5	9	9
343	B:B:D76	B:B:H54	3.78	Yes	Yes	5	9	9
344	B:B:H54	B:B:K78	2.62	Yes	Yes	5	9	8
345	B:B:H54	B:B:I80	13.26	Yes	Yes	5	9	8
346	B:B:H54	B:B:W82	3.17	Yes	Yes	5	9	9
347	B:B:A56	B:B:D76	4.63	No	Yes	0	7	9
348	B:B:K57	B:B:Y59	7.17	No	Yes	1	9	8
349	B:B:K57	B:B:W332	24.37	No	Yes	1	9	9
350	B:B:I58	B:B:S74	3.1	No	No	5	9	9
351	B:B:I58	B:B:L336	2.85	No	Yes	5	9	7
352	B:B:Q75	B:B:Y59	21.42	No	Yes	1	9	8
353	B:B:W332	B:B:Y59	7.72	Yes	Yes	1	9	8
354	B:B:M61	B:B:W63	4.65	No	Yes	0	6	7
355	B:B:C317	B:B:M61	4.86	No	No	0	7	6
356	B:B:L336	B:B:M61	2.83	Yes	No	0	7	6
357	B:B:H62	B:B:R150	15.8	No	No	0	6	6
358	B:B:L70	B:B:W63	15.94	No	Yes	0	5	7
359	B:B:S84	B:B:W63	6.18	No	Yes	0	5	7
360	B:B:T321	B:B:W63	13.34	No	Yes	0	7	7
361	B:B:A328	B:B:W63	3.89	No	Yes	0	5	7
362	B:B:G64	B:B:Y105	5.79	No	Yes	0	5	6
363	B:B:D322	B:B:T65	2.89	No	No	0	1	1
364	B:B:D66	B:B:R68	3.57	No	Yes	0	8	5
365	B:B:D66	B:B:L69	6.79	No	No	0	8	5
366	B:B:S67	B:B:T321	7.99	No	No	24	5	7
367	B:B:D323	B:B:S67	10.31	No	No	24	7	5
368	B:B:D83	B:B:R68	15.48	No	Yes	0	8	5
369	B:B:R68	B:B:S84	2.64	Yes	No	0	5	5
370	B:B:R68	B:B:Y85	24.69	Yes	No	0	5	4
371	B:B:L69	B:B:Y105	5.86	No	Yes	0	5	6
372	B:B:L70	B:B:W82	6.83	No	Yes	0	5	9
373	B:B:I81	B:B:V71	3.07	Yes	Yes	3	7	8
374	B:B:C103	B:B:V71	3.42	No	Yes	0	8	8
375	B:B:V71	B:B:Y105	5.05	Yes	Yes	3	8	6
376	B:B:V112	B:B:V71	4.81	Yes	Yes	3	8	8
377	B:B:S72	B:B:W82	7.41	No	Yes	5	9	9
378	B:B:L336	B:B:S72	4.5	Yes	No	5	7	9
379	B:B:A73	B:B:V100	5.09	No	No	0	9	9
380	B:B:A73	B:B:C103	3.61	No	No	0	9	8
381	B:B:D76	B:B:S74	8.83	Yes	No	5	9	9
382	B:B:Q75	B:B:W99	6.57	No	Yes	1	9	9
383	B:B:D76	B:B:K78	8.3	Yes	Yes	5	9	8
384	B:B:G77	B:B:L95	5.13	No	Yes	0	8	8
385	B:B:I93	B:B:L79	5.71	Yes	No	3	7	7
386	B:B:L79	B:B:L95	5.54	No	Yes	3	7	8
387	B:B:C114	B:B:L79	7.94	Yes	No	3	8	7
388	B:B:I80	B:B:W82	15.27	Yes	Yes	5	8	9
389	B:B:I80	B:B:K89	8.72	Yes	Yes	5	8	9
390	B:B:I81	B:B:V90	3.07	Yes	No	3	7	5
391	B:B:H91	B:B:I81	6.63	Yes	Yes	3	5	7
392	B:B:I81	B:B:L126	4.28	Yes	Yes	3	7	5
393	B:B:K89	B:B:W82	12.76	Yes	Yes	5	9	9
394	B:B:L336	B:B:W82	4.56	Yes	Yes	5	7	9
395	B:B:D83	B:B:T86	7.23	No	No	21	8	6
396	B:B:D83	B:B:N88	2.69	No	Yes	21	8	7
397	B:B:S84	G:G:F61	5.28	No	Yes	0	5	8
398	B:B:Y85	G:G:P60	13.91	No	Yes	5	4	9
399	B:B:Y85	G:G:F61	7.22	No	Yes	5	4	8
400	B:B:N88	B:B:T86	10.24	Yes	No	21	7	6
401	B:B:H91	B:B:V90	5.54	Yes	No	3	5	5
402	B:B:H91	B:B:V133	5.54	Yes	Yes	3	5	4
403	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
404	B:B:I93	B:B:Y124	4.84	Yes	Yes	3	7	6
405	B:B:I93	B:B:V133	9.22	Yes	Yes	3	7	4
406	B:B:L95	B:B:V100	4.47	Yes	No	3	8	9
407	B:B:C114	B:B:L95	4.76	Yes	Yes	3	8	8
408	B:B:L95	B:B:Y124	5.86	Yes	Yes	3	8	6
409	B:B:R96	B:B:V135	10.46	No	No	3	6	4
410	B:B:E138	B:B:R96	9.3	Yes	No	3	6	6
411	B:B:S97	B:B:W99	3.71	No	Yes	0	8	9
412	B:B:D118	B:B:S97	10.31	No	No	0	9	8
413	B:B:S98	B:B:W99	7.41	No	Yes	0	8	9
414	B:B:L117	B:B:W99	4.56	Yes	Yes	1	9	9
415	B:B:C114	B:B:V100	3.42	Yes	No	3	8	9
416	B:B:G116	B:B:M101	3.49	No	No	0	9	9
417	B:B:L117	B:B:M101	2.83	Yes	No	0	9	9
418	B:B:M101	B:B:Y145	7.18	No	Yes	0	9	8
419	B:B:C148	B:B:T102	3.38	No	No	0	6	8
420	B:B:C149	B:B:T102	5.07	Yes	No	0	8	8
421	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
422	B:B:G109	B:B:Y105	5.79	No	Yes	0	5	6
423	B:B:V112	B:B:Y105	3.79	Yes	Yes	3	8	6
424	B:B:L126	B:B:Y105	3.52	Yes	Yes	3	5	6
425	B:B:A106	B:B:F151	8.32	No	Yes	0	6	9
426	B:B:F151	B:B:P107	2.89	Yes	No	0	9	6
427	B:B:N110	B:B:S108	7.45	Yes	No	10	4	6
428	B:B:D154	B:B:S108	10.31	No	No	10	6	6
429	B:B:N110	B:B:Y111	3.49	Yes	Yes	10	4	4
430	B:B:K127	B:B:N110	8.39	No	Yes	0	4	4
431	B:B:D154	B:B:N110	6.73	No	Yes	10	6	4
432	B:B:I123	B:B:Y111	3.63	Yes	Yes	0	6	4
433	B:B:N125	B:B:Y111	11.63	No	Yes	10	4	4
434	B:B:D154	B:B:Y111	9.2	No	Yes	10	6	4
435	B:B:V112	B:B:Y124	3.79	Yes	Yes	3	8	6
436	B:B:L126	B:B:V112	5.96	Yes	Yes	3	5	8
437	B:B:A113	B:B:F151	2.77	No	Yes	0	9	9
438	B:B:C114	B:B:Y124	4.03	Yes	Yes	3	8	6
439	B:B:D118	B:B:I120	8.4	No	No	0	9	6
440	B:B:G144	B:B:N119	5.09	No	Yes	0	8	9
441	B:B:I120	B:B:S122	3.1	No	No	3	6	8
442	B:B:E138	B:B:I120	5.47	Yes	No	3	6	6
443	B:B:C121	B:B:L146	3.17	No	Yes	1	8	7
444	B:B:C121	B:B:C149	3.64	No	Yes	1	8	8
445	B:B:C121	B:B:T159	3.38	No	Yes	1	8	9
446	B:B:S122	B:B:Y124	5.09	No	Yes	3	8	6
447	B:B:E138	B:B:S122	5.75	Yes	No	3	6	8
448	B:B:I123	B:B:L139	4.28	Yes	No	0	6	9
449	B:B:F151	B:B:I123	3.77	Yes	Yes	0	9	6
450	B:B:I123	B:B:I171	7.36	Yes	No	0	6	6
451	B:B:V133	B:B:Y124	3.79	Yes	Yes	3	4	6
452	B:B:V135	B:B:Y124	6.31	No	Yes	3	4	6
453	B:B:N125	B:B:T128	5.85	No	No	10	4	3
454	B:B:N125	B:B:R134	4.82	No	No	10	4	3
455	B:B:L126	B:B:V133	4.47	Yes	Yes	3	5	4
456	B:B:R134	B:B:T128	9.06	No	No	10	3	3
457	B:B:E130	B:B:N132	6.57	No	No	0	3	3
458	B:B:E130	B:B:R134	11.63	No	No	0	3	3
459	B:B:E138	B:B:V135	4.28	Yes	No	3	6	4
460	B:B:R137	B:B:S136	2.64	No	No	0	5	4
461	B:B:L139	B:B:W169	17.08	No	Yes	0	9	8
462	B:B:H142	B:B:L146	3.86	Yes	Yes	1	9	7
463	B:B:H142	B:B:T159	6.85	Yes	Yes	1	9	9
464	B:B:H142	B:B:S161	16.74	Yes	No	1	9	9
465	B:B:D163	B:B:H142	5.04	Yes	Yes	1	9	9
466	B:B:H142	B:B:T165	2.74	Yes	No	0	9	7
467	B:B:A167	B:B:H142	2.93	No	Yes	0	4	9
468	B:B:H142	B:B:W169	3.17	Yes	Yes	1	9	8
469	B:B:D163	B:B:T143	11.56	Yes	No	0	9	5
470	B:B:D163	B:B:G144	5.03	Yes	No	0	9	8
471	B:B:G162	B:B:Y145	4.35	No	Yes	1	9	8
472	B:B:D186	B:B:Y145	10.34	Yes	Yes	1	9	8
473	B:B:M188	B:B:Y145	5.99	No	Yes	1	8	8
474	B:B:C149	B:B:L146	3.17	Yes	Yes	1	8	7
475	B:B:L146	B:B:T159	5.9	Yes	Yes	1	7	9
476	B:B:S147	B:B:S160	4.89	No	Yes	0	9	6
477	B:B:C148	B:B:R150	5.57	No	No	0	6	6
478	B:B:C149	B:B:I157	3.27	Yes	Yes	1	8	7
479	B:B:C149	B:B:T159	3.38	Yes	Yes	1	8	9
480	B:B:F151	B:B:I157	6.28	Yes	Yes	0	9	7
481	B:B:D153	B:B:L152	2.71	No	Yes	4	5	3
482	B:B:L152	B:B:Q156	7.99	Yes	No	4	3	5
483	B:B:L152	B:B:L192	5.54	Yes	No	0	3	5
484	B:B:L152	B:B:T196	2.95	Yes	No	0	3	1
485	B:B:D153	B:B:Q156	9.14	No	No	4	5	5
486	B:B:D170	B:B:N155	6.73	No	No	0	9	3
487	B:B:E172	B:B:N155	7.89	No	No	0	6	3
488	B:B:L168	B:B:Q156	2.66	No	No	4	6	5
489	B:B:I157	B:B:T159	3.04	Yes	Yes	1	7	9
490	B:B:I157	B:B:W169	3.52	Yes	Yes	1	7	8
491	B:B:I157	B:B:I171	4.42	Yes	No	0	7	6
492	B:B:L190	B:B:V158	2.98	No	No	0	5	5
493	B:B:L192	B:B:V158	4.47	No	No	0	5	5
494	B:B:F199	B:B:V158	3.93	Yes	No	0	9	5
495	B:B:T159	B:B:W169	9.7	Yes	Yes	1	9	8
496	B:B:C166	B:B:S160	3.44	Yes	Yes	4	8	6
497	B:B:S160	B:B:V187	6.46	Yes	Yes	4	6	9
498	B:B:L190	B:B:S160	3	No	Yes	0	5	6
499	B:B:G162	B:B:S161	3.71	No	No	1	9	9
500	B:B:D163	B:B:S161	8.83	Yes	No	1	9	9
501	B:B:D186	B:B:G162	5.03	Yes	No	1	9	9
502	B:B:T165	B:B:T181	3.14	No	No	0	7	2
503	B:B:C166	B:B:F180	2.79	Yes	Yes	4	8	7
504	B:B:C166	B:B:V187	5.12	Yes	Yes	4	8	9
505	B:B:C166	B:B:F199	4.19	Yes	Yes	4	8	9
506	B:B:C166	B:B:S201	3.44	Yes	Yes	4	8	9
507	B:B:A167	B:B:Q176	6.06	No	Yes	0	4	4
508	B:B:L168	B:B:T177	4.42	No	No	4	6	4
509	B:B:L168	B:B:T178	4.42	No	No	4	6	4
510	B:B:Q176	B:B:W169	15.33	Yes	Yes	0	4	8
511	B:B:D170	B:B:T173	8.67	No	No	0	9	5
512	B:B:D170	B:B:T177	2.89	No	No	0	9	4
513	B:B:G174	B:B:T173	3.64	No	No	0	4	5
514	B:B:Q175	B:B:T173	7.09	No	No	0	4	5
515	B:B:Q176	B:B:T179	7.09	Yes	No	0	4	4
516	B:B:T177	B:B:T178	4.71	No	No	4	4	4
517	B:B:F180	B:B:T178	9.08	Yes	No	4	7	4
518	B:B:F180	B:B:F199	12.86	Yes	Yes	4	7	9
519	B:B:F180	B:B:W211	15.03	Yes	Yes	4	7	8
520	B:B:F180	B:B:G216	4.52	Yes	No	0	7	4
521	B:B:G182	B:B:T181	3.64	No	No	0	6	2
522	B:B:H183	B:B:V187	6.92	Yes	Yes	4	9	9
523	B:B:H183	B:B:S201	5.58	Yes	Yes	4	9	9
524	B:B:A203	B:B:H183	8.78	No	Yes	4	8	9
525	B:B:D205	B:B:H183	5.04	Yes	Yes	4	9	9
526	B:B:H183	B:B:S207	2.79	Yes	No	4	9	5
527	B:B:H183	B:B:K209	15.72	Yes	Yes	4	9	6
528	B:B:H183	B:B:W211	3.17	Yes	Yes	4	9	8
529	B:B:D205	B:B:T184	10.12	Yes	No	0	9	3
530	B:B:C204	B:B:D186	3.11	Yes	Yes	1	7	9
531	B:B:S201	B:B:V187	3.23	Yes	Yes	4	9	9
532	B:B:A203	B:B:V187	3.39	No	Yes	4	8	9
533	B:B:C204	B:B:M188	3.24	Yes	No	1	7	8
534	B:B:I232	B:B:S189	4.64	Yes	No	0	8	7
535	B:B:F234	B:B:S191	3.96	Yes	No	0	5	8
536	B:B:A193	B:B:D195	3.09	No	No	0	4	5
537	B:B:A193	B:B:F234	2.77	No	Yes	0	4	5
538	B:B:F234	B:B:P194	2.89	Yes	No	0	5	4
539	B:B:G238	B:B:P194	4.06	No	No	0	7	4
540	B:B:D195	B:B:R197	5.96	No	No	0	5	5
541	B:B:R197	B:B:R214	13.86	No	No	0	5	9
542	B:B:L198	B:B:L210	4.15	No	Yes	0	3	5
543	B:B:D212	B:B:L198	5.43	No	No	0	9	3
544	B:B:F199	B:B:W211	13.03	Yes	Yes	4	9	8
545	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
546	B:B:L210	B:B:V200	2.98	Yes	Yes	0	5	6
547	B:B:I232	B:B:V200	6.14	Yes	Yes	1	8	6
548	B:B:F234	B:B:V200	7.87	Yes	Yes	1	5	6
549	B:B:F241	B:B:V200	7.87	Yes	Yes	1	6	6
550	B:B:S201	B:B:W211	7.41	Yes	Yes	4	9	8
551	B:B:G202	B:B:I229	5.29	No	No	0	6	7
552	B:B:A203	B:B:D205	3.09	No	Yes	4	8	9
553	B:B:C204	B:B:D228	7.78	Yes	Yes	1	7	9
554	B:B:D205	B:B:S207	10.31	Yes	No	4	9	5
555	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
556	B:B:K209	B:B:W211	6.96	Yes	Yes	4	6	8
557	B:B:C218	B:B:K209	8.08	No	Yes	4	5	6
558	B:B:K209	B:B:T221	13.51	Yes	No	0	6	7
559	B:B:L210	B:B:R219	3.64	Yes	No	0	5	5
560	B:B:L210	B:B:Q220	6.65	Yes	Yes	0	5	7
561	B:B:L210	B:B:L255	6.92	Yes	No	0	5	6
562	B:B:C218	B:B:W211	5.22	No	Yes	4	5	8
563	B:B:D212	B:B:E215	9.09	No	No	0	9	3
564	B:B:D212	B:B:R219	16.68	No	No	0	9	5
565	B:B:E215	B:B:M217	4.06	No	No	0	3	3
566	B:B:M217	B:B:R219	16.13	No	No	0	3	5
567	B:B:C218	G:G:Q18	6.1	No	No	0	5	9
568	B:B:F222	B:B:Q220	7.03	Yes	Yes	1	8	7
569	B:B:D258	B:B:Q220	14.36	Yes	Yes	1	7	7
570	B:B:Q220	G:G:I25	4.12	Yes	No	0	7	2
571	B:B:T221	G:G:E22	9.88	No	No	0	7	9
572	B:B:F222	B:B:F241	11.79	Yes	Yes	1	8	6
573	B:B:F222	B:B:F253	11.79	Yes	Yes	1	8	6
574	B:B:D258	B:B:F222	3.58	Yes	Yes	1	7	8
575	B:B:G224	B:B:T223	3.64	No	No	0	6	2
576	B:B:H225	B:B:I229	9.28	Yes	No	1	9	7
577	B:B:H225	B:B:T243	10.95	Yes	Yes	1	9	8
578	B:B:H225	B:B:S245	13.95	Yes	No	1	9	9
579	B:B:D247	B:B:H225	6.3	Yes	Yes	1	9	9
580	B:B:H225	B:B:R251	14.67	Yes	Yes	1	9	8
581	B:B:D247	B:B:E226	5.2	Yes	No	0	9	3
582	B:B:D228	B:B:S227	7.36	Yes	No	1	9	6
583	B:B:D246	B:B:S227	2.94	Yes	No	1	9	6
584	B:B:D247	B:B:S227	2.94	Yes	No	1	9	6
585	B:B:D228	B:B:N230	4.04	Yes	No	1	9	9
586	B:B:D228	B:B:D246	5.32	Yes	Yes	1	9	9
587	B:B:I229	B:B:T243	6.08	No	Yes	1	7	8
588	B:B:D246	B:B:N230	5.39	Yes	No	1	9	9
589	B:B:F241	B:B:I232	5.02	Yes	Yes	1	6	8
590	B:B:I232	B:B:T243	3.04	Yes	Yes	1	8	8
591	B:B:F234	B:B:F241	5.36	Yes	Yes	1	5	6
592	B:B:F235	B:B:P236	8.67	Yes	Yes	1	6	7
593	B:B:A240	B:B:F235	2.77	No	Yes	1	6	6
594	B:B:F235	B:B:F278	11.79	Yes	Yes	1	6	7
595	B:B:F235	B:B:G282	4.52	Yes	No	1	6	9
596	B:B:F235	G:G:L37	4.87	Yes	No	1	6	7
597	B:B:F235	G:G:Y40	6.19	Yes	Yes	1	6	6
598	B:B:F235	G:G:C41	2.79	Yes	No	1	6	7
599	B:B:F278	B:B:P236	2.89	Yes	Yes	1	7	7
600	B:B:G282	B:B:P236	4.06	No	Yes	1	9	7
601	B:B:P236	G:G:Y40	5.56	Yes	Yes	1	7	6
602	B:B:N237	B:B:N239	12.26	No	No	0	5	2
603	B:B:N237	G:G:Y40	10.47	No	Yes	0	5	6
604	B:B:N239	B:B:R256	7.23	No	No	0	2	9
605	B:B:A240	G:G:L37	3.15	No	No	1	6	7
606	B:B:F241	B:B:F253	11.79	Yes	Yes	1	6	6
607	B:B:A242	B:B:F278	2.77	No	Yes	1	4	7
608	B:B:A242	B:B:L285	4.73	No	No	1	4	6
609	B:B:F253	B:B:T243	7.78	Yes	Yes	1	6	8
610	B:B:G244	B:B:I273	5.29	No	No	0	5	6
611	B:B:D247	B:B:S245	10.31	Yes	No	1	9	9
612	B:B:D246	B:B:G272	3.35	Yes	No	0	9	4
613	B:B:D247	B:B:T249	7.23	Yes	Yes	1	9	6
614	B:B:A248	B:B:I269	3.25	No	Yes	0	5	4
615	B:B:R251	B:B:T249	6.47	Yes	Yes	1	8	6
616	B:B:T249	B:B:T263	3.14	Yes	Yes	1	6	1
617	B:B:C250	B:B:Y264	4.03	No	Yes	0	8	5
618	B:B:C250	B:B:I273	4.91	No	No	0	8	6
619	B:B:F253	B:B:R251	3.21	Yes	Yes	1	6	8
620	B:B:E260	B:B:R251	20.93	Yes	Yes	1	6	8
621	B:B:R251	B:B:T263	5.17	Yes	Yes	1	8	1
622	B:B:L252	B:B:Y264	5.86	No	Yes	0	7	5
623	B:B:F278	B:B:L252	3.65	Yes	No	0	7	7
624	B:B:E260	B:B:F253	5.83	Yes	Yes	1	6	6
625	B:B:A257	B:B:D254	4.63	No	Yes	0	7	9
626	B:B:D254	B:B:L261	6.79	Yes	No	0	9	5
627	B:B:D254	G:G:A33	4.63	Yes	No	0	9	7
628	B:B:D254	G:G:L37	2.71	Yes	No	0	9	7
629	B:B:R256	G:G:I28	8.77	No	No	0	9	4
630	B:B:R256	G:G:D36	8.34	No	No	0	9	5
631	B:B:D258	G:G:R27	13.1	Yes	Yes	1	7	8
632	B:B:Q259	G:G:V30	5.73	No	No	0	6	8
633	B:B:E260	B:B:T263	2.82	Yes	Yes	1	6	1
634	B:B:L261	G:G:V30	2.98	No	No	0	5	8
635	B:B:M262	B:B:Y264	9.58	Yes	Yes	1	4	5
636	B:B:A302	B:B:M262	3.22	No	Yes	1	2	4
637	B:B:L285	B:B:Y264	5.86	No	Yes	1	6	5
638	B:B:W297	B:B:Y264	12.54	No	Yes	1	8	5
639	B:B:A302	B:B:Y264	4	No	Yes	1	2	5
640	B:B:H266	B:B:N268	3.83	No	No	0	4	4
641	B:B:H266	B:B:I269	3.98	No	Yes	0	4	4
642	B:B:I269	B:B:Y289	7.25	Yes	Yes	1	4	7
643	B:B:I269	B:B:N295	4.25	Yes	Yes	1	4	6
644	B:B:C271	B:B:Y289	4.03	No	Yes	1	5	7
645	B:B:C271	B:B:D290	4.67	No	Yes	1	5	6
646	B:B:C271	B:B:D291	7.78	No	No	1	5	8
647	B:B:D290	B:B:G272	3.35	Yes	No	0	6	4
648	B:B:I273	B:B:Y289	8.46	No	Yes	0	6	7
649	B:B:S275	B:B:T274	4.8	No	No	0	8	8
650	B:B:D290	B:B:T274	2.89	Yes	No	1	6	8
651	B:B:R314	B:B:T274	3.88	No	No	1	8	8
652	B:B:L318	B:B:S275	7.51	Yes	No	0	6	8
653	B:B:L318	B:B:S277	3	Yes	No	25	6	5
654	B:B:G319	B:B:S277	3.71	No	No	25	5	5
655	B:B:S277	B:B:V320	4.85	No	No	0	5	7
656	B:B:F278	B:B:G282	3.01	Yes	No	1	7	9
657	B:B:F278	B:B:L285	10.96	Yes	No	1	7	6
658	B:B:A299	B:B:F278	2.77	No	Yes	0	5	7
659	B:B:S279	G:G:D48	10.31	No	Yes	1	9	9
660	B:B:S279	G:G:L50	4.5	No	Yes	1	9	9
661	B:B:G324	B:B:K280	5.23	No	No	0	9	1
662	B:B:K280	G:G:D48	2.77	No	Yes	0	1	9
663	B:B:S281	G:G:D48	10.31	No	Yes	0	9	9
664	B:B:D298	B:B:R283	13.1	Yes	Yes	1	9	9
665	B:B:L300	B:B:R283	9.72	Yes	Yes	1	6	9
666	B:B:R283	G:G:C41	4.18	Yes	No	1	9	7
667	B:B:R283	G:G:L51	3.64	Yes	Yes	1	9	6
668	B:B:L284	B:B:V296	4.47	No	Yes	0	5	5
669	B:B:L284	G:G:L51	2.77	No	Yes	0	5	6
670	B:B:L286	B:B:V296	4.47	No	Yes	0	7	5
671	B:B:L286	B:B:V327	5.96	No	No	0	7	6
672	B:B:A287	B:B:Y289	4	No	Yes	0	6	7
673	B:B:G288	B:B:V315	3.68	No	No	0	7	7
674	B:B:D291	B:B:Y289	3.45	No	Yes	1	8	7
675	B:B:N295	B:B:Y289	11.63	Yes	Yes	1	6	7
676	B:B:W297	B:B:Y289	6.75	No	Yes	1	8	7
677	B:B:D290	B:B:R314	21.44	Yes	No	1	6	8
678	B:B:D291	B:B:N293	9.42	No	No	0	8	5
679	B:B:F292	B:B:N313	3.62	No	No	0	4	7
680	B:B:N293	B:B:V307	5.91	No	No	0	5	3
681	B:B:A309	B:B:N293	3.13	No	No	0	3	5
682	B:B:C294	B:B:L308	7.94	No	Yes	0	5	7
683	B:B:N295	B:B:W297	4.52	Yes	No	1	6	8
684	B:B:A305	B:B:N295	3.13	No	Yes	0	4	6
685	B:B:R304	B:B:V296	2.62	Yes	Yes	0	5	5
686	B:B:L308	B:B:V296	4.47	Yes	Yes	0	7	5
687	B:B:D298	B:B:K301	11.06	Yes	No	1	9	5
688	B:B:D298	B:B:D303	3.99	Yes	No	1	9	2
689	B:B:L300	G:G:C41	6.35	Yes	No	1	6	7
690	B:B:D303	B:B:K301	9.68	No	No	1	2	5
691	B:B:G306	B:B:R304	4.5	No	Yes	0	4	5
692	B:B:L308	B:B:W339	15.94	Yes	Yes	1	7	9
693	B:B:G310	B:B:K337	3.49	No	Yes	1	5	6
694	B:B:G310	B:B:W339	2.81	No	Yes	1	5	9
695	B:B:H311	B:B:V315	5.54	Yes	No	0	9	7
696	B:B:H311	B:B:T329	8.21	Yes	No	0	9	8
697	B:B:H311	B:B:S331	16.74	Yes	No	1	9	9
698	B:B:D333	B:B:H311	6.3	Yes	Yes	1	9	9
699	B:B:H311	B:B:K337	11.79	Yes	Yes	1	9	6
700	B:B:D312	B:B:D333	5.32	No	Yes	0	5	9
701	B:B:D312	R:R:K74	5.53	No	No	0	5	6
702	B:B:N313	B:B:W332	6.78	No	Yes	0	7	9
703	B:B:R314	B:B:W332	20.99	No	Yes	1	8	9
704	B:B:C317	B:B:S316	3.44	No	No	0	7	9
705	B:B:S316	B:B:W332	6.18	No	Yes	0	9	9
706	B:B:G319	B:B:L318	3.42	No	Yes	25	5	6
707	B:B:L318	B:B:T329	4.42	Yes	No	0	6	8
708	B:B:V320	B:B:V327	3.21	No	No	0	7	6
709	B:B:D323	B:B:T321	10.12	No	No	24	7	7
710	B:B:D323	B:B:M325	5.54	No	No	0	7	5
711	B:B:M325	G:G:P49	6.71	No	No	0	5	7
712	B:B:M325	G:G:P60	6.71	No	Yes	0	5	9
713	B:B:A326	G:G:F61	4.16	No	Yes	0	7	8
714	B:B:V327	G:G:L50	4.47	No	Yes	0	6	9
715	B:B:T329	B:B:W339	7.28	No	Yes	0	8	9
716	B:B:D333	B:B:S331	8.83	Yes	No	1	9	9
717	B:B:D333	B:B:F335	10.75	Yes	No	0	9	4
718	B:B:F335	B:B:S334	2.64	No	No	0	4	4
719	B:B:K337	B:B:W339	5.8	Yes	Yes	1	6	9
720	B:B:I338	G:G:F61	5.02	No	Yes	5	5	8
721	B:B:N340	G:G:N59	6.81	Yes	No	0	9	9
722	B:B:N340	G:G:F61	3.62	Yes	Yes	0	9	8
723	G:G:N5	G:G:S8	7.45	No	No	0	4	4
724	G:G:I9	G:G:S8	3.1	No	No	0	2	4
725	G:G:I9	G:G:R13	3.76	No	No	0	2	6
726	G:G:E17	G:G:V16	4.28	No	Yes	20	6	7
727	G:G:K20	G:G:V16	3.04	Yes	Yes	20	6	7
728	G:G:E17	G:G:K20	8.1	No	Yes	20	6	6
729	G:G:E22	G:G:Q18	10.19	No	No	0	9	9
730	G:G:I28	G:G:K32	5.82	No	No	0	4	5
731	G:G:A33	G:G:I28	3.25	No	No	0	7	4
732	G:G:D36	G:G:K32	4.15	No	No	0	5	5
733	G:G:H44	G:G:Y40	18.51	No	Yes	0	6	6
734	G:G:A43	G:G:H44	2.93	No	No	0	4	6
735	G:G:D48	G:G:P49	3.22	Yes	No	0	9	7
736	G:G:D48	G:G:L50	2.71	Yes	Yes	1	9	9
737	G:G:D48	G:G:L51	8.14	Yes	Yes	1	9	6
738	G:G:L51	G:G:T52	2.95	Yes	No	0	6	4
739	G:G:P55	G:G:V54	3.53	No	No	26	5	6
740	G:G:E58	G:G:V54	4.28	No	No	26	5	6
741	G:G:N59	G:G:V54	4.43	No	No	0	9	6
742	G:G:E58	G:G:P55	14.15	No	No	26	5	5
743	G:G:E58	G:G:S57	4.31	No	No	0	5	6
744	G:G:N59	G:G:P60	6.52	No	Yes	0	9	9
745	G:G:F61	G:G:P60	4.33	Yes	Yes	5	8	9
746	R:R:D23	R:R:N21	5.39	No	No	0	7	8
747	R:R:H28	R:R:I24	3.98	Yes	Yes	0	8	4
748	R:R:I185	R:R:I24	2.94	No	Yes	0	3	4
749	R:R:I25	R:R:Y29	3.63	Yes	Yes	2	4	7
750	R:R:I25	R:R:W117	4.7	Yes	Yes	2	4	9
751	R:R:I25	R:R:L197	5.71	Yes	Yes	2	4	4
752	R:R:C184	R:R:H28	2.95	No	Yes	0	5	8
753	R:R:H28	R:R:L188	6.43	Yes	No	0	8	2
754	R:R:H28	R:R:L197	7.71	Yes	Yes	0	8	4
755	R:R:K34	R:R:Y29	3.58	No	Yes	2	6	7
756	R:R:Y110	R:R:Y29	6.95	No	Yes	0	5	7
757	R:R:P196	R:R:Y29	11.13	Yes	Yes	2	3	7
758	R:R:L35	R:R:N30	9.61	No	No	0	6	9
759	R:R:L188	R:R:Y31	10.55	No	No	0	2	5
760	R:R:C191	R:R:Y31	5.38	No	No	0	9	5
761	R:R:K34	R:R:T32	3	No	Yes	2	6	8
762	R:R:T193	R:R:T32	4.71	No	Yes	0	5	8
763	R:R:P196	R:R:T32	5.25	Yes	Yes	2	3	8
764	R:R:K34	R:R:P196	3.35	No	Yes	2	6	3
765	R:R:A107	R:R:N36	4.69	No	No	0	4	4
766	R:R:N36	R:R:Y110	5.81	No	No	0	4	5
767	R:R:K46	R:R:T48	4.5	No	No	0	4	5
768	R:R:F52	R:R:T48	7.78	Yes	No	14	6	5
769	R:R:T48	R:R:Y295	6.24	No	Yes	14	5	3
770	R:R:F52	R:R:V51	2.62	Yes	No	0	6	5
771	R:R:F52	R:R:L102	3.65	Yes	No	0	6	5
772	R:R:E294	R:R:F52	4.66	No	Yes	14	3	6
773	R:R:F52	R:R:Y295	6.19	Yes	Yes	14	6	3
774	R:R:F52	R:R:V298	22.28	Yes	No	0	6	5
775	R:R:I53	R:R:T99	3.04	No	Yes	0	3	6
776	R:R:I55	R:R:V298	3.07	No	No	0	6	5
777	R:R:C56	R:R:I60	3.27	Yes	No	0	5	6
778	R:R:C56	R:R:Y98	4.03	Yes	Yes	0	5	6
779	R:R:E62	R:R:F58	16.32	Yes	No	0	8	4
780	R:R:E62	R:R:I59	4.1	Yes	Yes	0	8	7
781	R:R:I59	R:R:N63	4.25	Yes	Yes	15	7	9
782	R:R:D91	R:R:I59	4.2	Yes	Yes	15	9	7
783	R:R:I59	R:R:V301	3.07	Yes	No	0	7	7
784	R:R:G305	R:R:I59	7.05	No	Yes	15	7	7
785	R:R:I60	R:R:I64	2.94	No	No	0	6	4
786	R:R:I60	R:R:L92	2.85	No	No	0	6	6
787	R:R:F65	R:R:L61	3.65	No	No	0	7	4
788	R:R:E62	R:R:I309	2.73	Yes	No	0	8	6
789	R:R:D91	R:R:N63	17.5	Yes	Yes	15	9	9
790	R:R:L92	R:R:N63	5.49	No	Yes	0	6	9
791	R:R:N63	R:R:P308	4.89	Yes	No	15	9	9
792	R:R:P308	R:R:V66	7.07	No	No	0	9	9
793	R:R:L68	R:R:T69	2.95	No	No	0	4	8
794	R:R:I70	R:R:K75	2.91	No	Yes	0	7	6
795	R:R:F76	R:R:W71	9.02	No	No	0	8	3
796	R:R:I323	R:R:K72	2.91	No	No	0	3	6
797	R:R:K75	R:R:T73	10.51	Yes	No	0	6	6
798	R:R:A321	R:R:T73	5.03	No	No	0	7	6
799	R:R:F76	R:R:K74	8.69	No	No	0	8	6
800	R:R:K75	R:R:R78	8.66	Yes	No	16	6	7
801	R:R:K75	R:R:Y81	10.75	Yes	Yes	16	6	9
802	R:R:E317	R:R:K75	4.05	No	Yes	0	7	6
803	R:R:K75	R:R:M318	2.88	Yes	Yes	16	6	8
804	R:R:R78	R:R:Y81	6.17	No	Yes	16	7	9
805	R:R:P79	R:R:S155	5.34	No	No	27	7	7
806	R:R:N157	R:R:P79	3.26	No	No	27	1	7
807	R:R:E141	R:R:M80	2.71	Yes	No	0	9	8
808	R:R:N315	R:R:Y81	8.14	Yes	Yes	16	8	9
809	R:R:M318	R:R:Y81	11.97	Yes	Yes	16	8	9
810	R:R:L160	R:R:Y82	7.03	No	No	0	7	4
811	R:R:A137	R:R:F83	2.77	No	Yes	0	7	8
812	R:R:F83	R:R:I138	3.77	Yes	Yes	0	8	8
813	R:R:E141	R:R:F83	9.33	Yes	Yes	0	9	8
814	R:R:F83	R:R:I164	5.02	Yes	Yes	0	8	7
815	R:R:I84	R:R:Y311	4.84	No	Yes	0	8	9
816	R:R:N86	R:R:S134	7.45	Yes	No	0	9	8
817	R:R:I164	R:R:N86	5.66	Yes	Yes	0	7	9
818	R:R:C167	R:R:N86	3.15	No	Yes	0	6	9
819	R:R:N86	R:R:W168	10.17	Yes	Yes	0	9	9
820	R:R:L87	R:R:S134	6.01	Yes	No	0	9	8
821	R:R:I138	R:R:L87	2.85	Yes	Yes	9	8	9
822	R:R:L87	R:R:N307	4.12	Yes	No	0	9	9
823	R:R:L87	R:R:Y311	3.52	Yes	Yes	9	9	9
824	R:R:A130	R:R:S90	3.42	No	No	0	7	8
825	R:R:D91	R:R:S304	10.31	Yes	No	0	9	9
826	R:R:D91	R:R:G305	5.03	Yes	No	15	9	7
827	R:R:D91	R:R:P308	4.83	Yes	No	15	9	9
828	R:R:L102	R:R:Y98	9.38	No	Yes	0	5	6
829	R:R:M124	R:R:Y98	7.18	No	Yes	0	6	6
830	R:R:L297	R:R:Y98	8.21	No	Yes	0	5	6
831	R:R:V298	R:R:Y98	7.57	No	Yes	0	5	6
832	R:R:V301	R:R:Y98	5.05	No	Yes	0	7	6
833	R:R:N101	R:R:S105	5.96	Yes	No	2	5	4
834	R:R:N101	R:R:R120	13.26	Yes	Yes	2	5	6
835	R:R:E121	R:R:N101	6.57	Yes	Yes	2	5	5
836	R:R:M124	R:R:N101	2.8	No	Yes	0	6	5
837	R:R:R120	R:R:S105	3.95	Yes	No	2	6	4
838	R:R:K111	R:R:T108	9.01	No	No	0	1	4
839	R:R:R120	R:R:T109	6.47	Yes	No	0	6	5
840	R:R:K111	R:R:L112	4.23	No	No	0	1	5
841	R:R:L112	R:R:Q116	11.98	No	No	0	5	4
842	R:R:P114	R:R:T113	6.99	No	Yes	0	3	7
843	R:R:A115	R:R:T113	3.36	No	Yes	0	2	7
844	R:R:Q116	R:R:T113	7.09	No	Yes	0	4	7
845	R:R:F118	R:R:W117	5.01	Yes	Yes	2	6	9
846	R:R:R120	R:R:W117	7	Yes	Yes	2	6	9
847	R:R:E121	R:R:W117	9.81	Yes	Yes	2	5	9
848	R:R:L195	R:R:W117	3.42	Yes	Yes	2	3	9
849	R:R:P196	R:R:W117	2.7	Yes	Yes	2	3	9
850	R:R:L197	R:R:W117	14.81	Yes	Yes	2	4	9
851	R:R:W117	R:R:Y198	4.82	Yes	Yes	2	9	4
852	R:R:F118	R:R:P178	2.89	Yes	Yes	2	6	5
853	R:R:F118	R:R:I179	6.28	Yes	No	0	6	5
854	R:R:F118	R:R:N183	9.67	Yes	No	0	6	5
855	R:R:F118	R:R:L197	7.31	Yes	Yes	2	6	4
856	R:R:E121	R:R:R120	11.63	Yes	Yes	2	5	6
857	R:R:E121	R:R:L195	2.65	Yes	Yes	2	5	3
858	R:R:E121	R:R:Y198	4.49	Yes	Yes	2	5	4
859	R:R:L128	R:R:M124	4.24	No	No	0	6	6
860	R:R:F125	R:R:L195	3.65	No	Yes	2	5	3
861	R:R:F125	R:R:Y198	6.19	No	Yes	2	5	4
862	R:R:F125	R:R:Y202	5.16	No	Yes	2	5	7
863	R:R:S171	R:R:V126	3.23	No	No	0	8	5
864	R:R:L172	R:R:V126	4.47	No	No	0	4	5
865	R:R:L128	R:R:W269	7.97	No	Yes	0	6	8
866	R:R:F133	R:R:S129	2.64	Yes	No	0	5	6
867	R:R:S129	R:R:S171	3.26	No	No	0	6	8
868	R:R:L174	R:R:S129	3	No	No	0	5	6
869	R:R:A130	R:R:W168	5.19	No	Yes	0	7	9
870	R:R:A130	R:R:S171	3.42	No	No	0	7	8
871	R:R:S131	R:R:S304	6.52	No	No	0	9	9
872	R:R:F210	R:R:V132	2.62	No	No	28	7	7
873	R:R:L213	R:R:V132	4.47	No	No	0	8	7
874	R:R:V132	R:R:W269	4.9	No	Yes	28	7	8
875	R:R:C167	R:R:F133	2.79	No	Yes	0	6	5
876	R:R:F133	R:R:I170	7.54	Yes	No	0	5	4
877	R:R:F133	R:R:V209	2.62	Yes	No	0	5	5
878	R:R:F133	R:R:L213	14.61	Yes	No	0	5	8
879	R:R:I217	R:R:L135	4.28	No	No	0	8	9
880	R:R:F265	R:R:L135	4.87	No	No	0	9	9
881	R:R:L135	R:R:Y311	4.69	No	Yes	0	9	9
882	R:R:I140	R:R:L136	7.14	No	No	0	6	7
883	R:R:L136	R:R:S216	3	No	No	0	7	6
884	R:R:I217	R:R:L136	4.28	No	No	0	8	7
885	R:R:A137	R:R:L163	4.73	No	No	0	7	6
886	R:R:I138	R:R:R142	7.52	Yes	Yes	9	8	9
887	R:R:I138	R:R:Y311	3.63	Yes	Yes	9	8	9
888	R:R:A139	R:R:L220	3.15	No	No	0	8	7
889	R:R:A139	R:R:Y221	4	No	Yes	0	8	9
890	R:R:I140	R:R:I144	2.94	No	No	0	6	4
891	R:R:I140	R:R:L163	5.71	No	No	0	6	6
892	R:R:E141	R:R:T145	4.23	Yes	No	0	9	8
893	R:R:E141	R:R:R159	9.3	Yes	No	0	9	5
894	R:R:R142	R:R:Y221	8.23	Yes	Yes	9	9	9
895	R:R:R142	R:R:Y311	8.23	Yes	Yes	9	9	9
896	R:R:L147	R:R:Y143	3.52	No	Yes	0	6	8
897	R:R:L220	R:R:Y143	7.03	No	Yes	0	7	8
898	R:R:R223	R:R:Y143	16.46	No	Yes	0	5	8
899	R:R:I224	R:R:Y143	4.84	No	Yes	0	9	8
900	R:R:I144	R:R:K148	2.91	No	No	0	4	6
901	R:R:I144	R:R:R159	15.03	No	No	0	4	5
902	R:R:I224	R:R:M146	4.37	No	No	0	9	8
903	R:R:L147	R:R:L227	2.77	No	No	0	6	6
904	R:R:M149	R:R:R231	12.41	Yes	No	0	8	7
905	R:R:K150	R:R:N153	2.8	No	No	19	7	4
906	R:R:G154	R:R:K150	5.23	No	No	19	4	7
907	R:R:H152	R:R:L151	3.86	No	Yes	0	7	4
908	R:R:G154	R:R:N153	3.39	No	No	19	4	4
909	R:R:N157	R:R:S155	5.96	No	No	27	1	7
910	R:R:N156	R:R:R159	12.05	No	No	0	7	5
911	R:R:N157	W:W:V41	4.43	No	No	0	1	0
912	R:R:I164	R:R:L160	5.71	Yes	No	0	7	7
913	R:R:F161	R:R:S165	9.25	Yes	No	29	2	4
914	R:R:F161	W:W:A44	2.77	Yes	No	0	2	0
915	R:R:F161	W:W:V45	5.24	Yes	Yes	29	2	0
916	R:R:F161	W:W:V48	2.62	Yes	No	0	2	0
917	R:R:I164	W:W:V45	3.07	Yes	Yes	0	7	0
918	R:R:S165	W:W:V45	3.23	No	Yes	29	4	0
919	R:R:V169	W:W:T52	7.93	No	No	0	4	0
920	R:R:L177	R:R:M180	2.83	No	No	0	5	4
921	R:R:L177	R:R:Y202	7.03	No	Yes	0	5	7
922	R:R:P178	R:R:Y198	12.52	Yes	Yes	2	5	4
923	R:R:P178	R:R:Y202	12.52	Yes	Yes	2	5	7
924	R:R:I179	W:W:A60	3.25	No	No	0	5	0
925	R:R:M180	W:W:I56	5.83	No	No	0	4	0
926	R:R:M180	W:W:I59	10.2	No	No	0	4	0
927	R:R:G181	R:R:N183	5.09	No	No	0	5	5
928	R:R:H199	R:R:W182	11.64	No	No	0	4	5
929	R:R:W182	R:R:Y202	4.82	No	Yes	0	5	7
930	R:R:I185	R:R:N183	11.33	No	No	0	3	5
931	R:R:C184	R:R:S190	3.44	No	No	0	5	4
932	R:R:H199	R:R:S190	5.58	No	No	0	4	4
933	R:R:S192	R:R:V194	3.23	No	Yes	0	4	4
934	R:R:I203	R:R:S192	3.1	No	No	0	6	4
935	R:R:K285	R:R:T193	3	No	No	0	2	5
936	R:R:F291	R:R:T193	5.19	No	No	0	1	5
937	R:R:L195	R:R:V194	2.98	Yes	Yes	2	3	4
938	R:R:D279	R:R:V194	5.84	No	Yes	2	4	4
939	R:R:L290	R:R:V194	4.47	Yes	Yes	2	3	4
940	R:R:L195	R:R:Y198	10.55	Yes	Yes	2	3	4
941	R:R:Y198	R:R:Y202	6.95	Yes	Yes	2	4	7
942	R:R:I203	R:R:Y198	4.84	No	Yes	0	6	4
943	R:R:H199	R:R:H201	14.33	No	No	0	4	4
944	R:R:K200	R:R:V280	3.04	No	No	0	3	4
945	R:R:H201	R:R:L204	5.14	No	No	0	4	5
946	R:R:I203	R:R:L276	2.85	No	No	0	6	6
947	R:R:L204	R:R:V280	2.98	No	No	0	5	4
948	R:R:F205	R:R:V209	3.93	No	No	0	5	5
949	R:R:L276	R:R:T207	4.42	No	No	0	6	5
950	R:R:L277	R:R:T207	2.95	No	No	0	6	5
951	R:R:F210	R:R:W269	16.04	No	Yes	28	7	8
952	R:R:F210	R:R:F273	3.22	No	Yes	0	7	6
953	R:R:F273	R:R:T211	7.78	Yes	No	0	6	4
954	R:R:F265	R:R:L214	7.31	No	No	0	9	5
955	R:R:I266	R:R:L214	4.28	No	No	0	6	5
956	R:R:I219	R:R:L215	2.85	No	No	0	4	4
957	R:R:L262	R:R:V218	5.96	No	No	0	7	4
958	R:R:V258	R:R:Y221	3.79	No	Yes	0	8	9
959	R:R:Y221	R:R:Y311	3.97	Yes	Yes	9	9	9
960	R:R:L254	R:R:Y225	3.52	Yes	Yes	0	8	6
961	R:R:L255	R:R:Y225	18.76	No	Yes	0	8	6
962	R:R:L254	R:R:V228	4.47	Yes	No	0	8	8
963	R:R:R229	R:R:R233	10.66	No	No	0	5	4
964	R:R:F237	R:R:L235	3.65	Yes	Yes	13	3	6
965	R:R:K239	R:R:R238	3.71	No	No	0	2	5
966	R:R:L254	R:R:V258	2.98	Yes	No	0	8	8
967	R:R:T257	R:R:T314	4.71	No	No	0	9	7
968	R:R:L262	R:R:V258	2.98	No	No	0	7	8
969	R:R:V261	R:R:Y311	3.79	No	Yes	0	8	9
970	R:R:S263	R:R:V264	3.23	No	No	0	5	7
971	R:R:I310	R:R:V264	4.61	No	No	0	8	7
972	R:R:F265	R:R:W269	7.02	No	Yes	0	9	8
973	R:R:C268	R:R:N303	4.72	No	No	0	8	9
974	R:R:N303	R:R:W269	12.43	No	Yes	0	9	8
975	R:R:F296	R:R:P271	2.89	No	No	0	4	9
976	R:R:L299	R:R:P271	3.28	No	No	0	7	9
977	R:R:F296	R:R:L272	6.09	No	No	0	4	6
978	R:R:L272	R:R:L299	2.77	No	No	0	6	7
979	R:R:A300	R:R:L272	3.15	No	No	0	7	6
980	R:R:F273	R:R:L277	7.31	Yes	No	0	6	6
981	R:R:L275	R:R:L290	2.77	No	Yes	0	4	3
982	R:R:F296	R:R:L275	19.49	No	No	0	4	4
983	R:R:D279	R:R:V280	2.92	No	No	0	4	4
984	R:R:D279	R:R:L290	4.07	No	Yes	2	4	3
985	R:R:C282	R:R:K283	3.23	No	No	0	4	1
986	R:R:C282	R:R:C287	3.64	No	No	0	4	3
987	R:R:K285	R:R:V284	4.55	No	No	0	2	1
988	R:R:C287	R:R:L290	3.17	No	Yes	0	3	3
989	R:R:E294	R:R:R292	5.82	No	No	14	3	4
990	R:R:R292	R:R:Y295	9.26	No	Yes	14	4	3
991	R:R:E294	R:R:Y295	11.22	No	Yes	14	3	3
992	R:R:N303	R:R:N307	9.54	No	No	0	9	9
993	R:R:I309	R:R:T306	3.04	No	No	0	6	5
994	R:R:I310	R:R:Y311	3.63	No	Yes	0	8	9
995	R:R:M318	R:R:T312	7.53	Yes	No	0	8	7
996	R:R:L313	R:R:R319	6.07	No	No	0	6	8
997	R:R:E317	R:R:N315	2.63	No	Yes	0	7	8
998	R:R:M318	R:R:N315	11.22	Yes	Yes	16	8	8
999	R:R:K316	R:R:R319	17.33	No	No	0	6	8
1000	R:R:E317	R:R:R320	3.49	No	No	0	7	5
1001	W:W:C43	W:W:P40	3.77	No	No	0	0	0
1002	W:W:L42	W:W:M46	2.83	No	No	0	0	0
1003	W:W:F50	W:W:M46	3.73	No	No	0	0	0
1004	W:W:I51	W:W:I55	2.94	No	No	0	0	0
1005	W:W:I51	Z:Z:H47	7.95	No	No	0	0	0
1006	W:W:L54	Z:Z:I54	4.28	No	No	0	0	0
1007	W:W:L54	Z:Z:K58	5.64	No	No	0	0	0
1008	W:W:I55	Z:Z:I54	4.42	No	No	0	0	0
1009	W:W:A57	Z:Z:K58	4.82	No	No	0	0	0
1010	W:W:I59	W:W:L58	2.85	No	No	0	0	0
1011	W:W:L61	Z:Z:F62	7.31	No	No	0	0	0
1012	Z:Z:N42	Z:Z:Q41	6.6	No	No	0	0	0
1013	Z:Z:T50	Z:Z:V53	4.76	No	No	0	0	0
1014	Z:Z:E57	Z:Z:V53	9.98	No	No	0	0	0
1015	Z:Z:D55	Z:Z:S56	4.42	No	No	0	0	0
1016	Z:Z:D55	Z:Z:D59	3.99	No	No	0	0	0
1017	Z:Z:E57	Z:Z:M60	8.12	No	No	0	0	0
1018	B:B:S136	B:B:Y111	2.54	No	Yes	0	4	4
1019	R:R:S251	R:R:Y225	2.54	No	Yes	0	7	6
1020	A:A:F274	A:A:I278	2.51	Yes	No	0	9	6
1021	R:R:F322	R:R:I325	2.51	No	No	0	7	6
1022	R:R:T113	R:R:Y22	2.5	Yes	No	0	7	5
1023	A:A:M18	A:A:R21	2.48	No	No	0	4	4
1024	R:R:L104	R:R:R120	2.43	No	Yes	0	4	6
1025	B:B:N16	B:B:R19	2.41	No	No	0	1	4
1026	R:R:D23	R:R:R27	2.38	No	No	0	7	3
1027	A:A:E25	A:A:R21	2.33	No	No	0	4	4
1028	R:R:L89	R:R:W168	2.28	No	Yes	0	5	9
1029	R:R:L93	R:R:W168	2.28	No	Yes	0	6	9
1030	A:A:E297	A:A:Y296	2.24	No	Yes	0	4	4
1031	B:B:G115	B:B:G116	2.11	No	No	0	9	9
1032	R:R:G122	R:R:G175	2.11	No	No	0	6	6
1033	R:R:G175	R:R:G176	2.11	No	No	0	6	4
1034	R:R:R229	R:R:Y225	2.06	No	Yes	0	5	6
1035	R:R:G176	R:R:P178	2.03	No	Yes	0	4	5
1036	B:B:C204	B:B:G185	1.96	Yes	No	0	7	5
1037	B:B:C317	B:B:G330	1.96	No	No	0	7	5
1038	R:R:C56	R:R:G95	1.96	Yes	No	0	5	7
1039	A:A:A41	A:A:G42	1.95	No	No	0	7	8
1040	B:B:A140	B:B:G141	1.95	No	No	0	5	5
1041	R:R:A88	R:R:G85	1.95	No	No	0	9	5
1042	R:R:A94	R:R:G95	1.95	No	No	0	8	7
1043	R:R:A270	R:R:P271	1.87	No	No	0	6	9
1044	A:A:G40	A:A:S44	1.86	No	No	0	9	9
1045	A:A:G45	A:A:S47	1.86	No	No	0	9	9
1046	R:R:G106	R:R:S105	1.86	No	No	0	4	4
1047	B:B:G41	B:B:V40	1.84	No	Yes	0	1	3
1048	B:B:G244	B:B:V276	1.84	No	No	0	5	6
1049	R:R:G181	W:W:V63	1.84	No	No	0	5	0
1050	W:W:G64	W:W:V63	1.84	No	No	0	0	0
1051	B:B:G131	B:B:T128	1.82	No	No	0	4	3
1052	B:B:G185	B:B:T164	1.82	No	No	0	5	6
1053	R:R:G33	R:R:T32	1.82	No	Yes	0	7	8
1054	B:B:A60	B:B:C103	1.81	No	No	0	7	8
1055	R:R:A127	R:R:A94	1.79	No	No	0	6	8
1056	R:R:A127	R:R:A97	1.79	No	No	0	6	4
1057	A:A:P282	A:A:T284	1.75	Yes	No	0	5	4
1058	B:B:P107	B:B:T65	1.75	No	No	0	6	1
1059	G:G:P53	G:G:T52	1.75	No	No	0	8	4
1060	A:A:G27	B:B:L55	1.71	No	No	0	5	6
1061	A:A:A41	A:A:S246	1.71	No	No	0	7	9
1062	B:B:C233	B:B:V276	1.71	No	No	0	3	6
1063	R:R:G33	R:R:L35	1.71	No	No	0	7	6
1064	R:R:G85	R:R:L67	1.71	No	No	0	5	8
1065	R:R:A97	R:R:S123	1.71	No	No	0	4	4
1066	R:R:A187	R:R:S189	1.71	No	No	0	4	4
1067	R:R:A187	R:R:S190	1.71	No	No	0	4	4
1068	R:R:C222	R:R:V218	1.71	No	No	0	3	4
1069	Z:Z:G48	Z:Z:L51	1.71	No	No	0	0	0
1070	B:B:A11	G:G:V16	1.7	No	Yes	0	5	7
1071	B:B:A231	B:B:V276	1.7	No	No	0	5	6
1072	R:R:A88	R:R:V66	1.7	No	No	0	9	9
1073	R:R:I24	R:R:P114	1.69	Yes	No	0	4	3
1074	R:R:C56	R:R:T99	1.69	Yes	Yes	0	5	6
1075	R:R:C282	R:R:T286	1.69	No	No	0	4	1
1076	A:A:D200	A:A:G202	1.68	No	No	0	9	9
1077	G:G:A7	G:G:T6	1.68	No	No	0	4	3
1078	R:R:A321	R:R:T69	1.68	No	No	0	7	8
1079	R:R:A100	R:R:T99	1.68	No	Yes	0	7	6
1080	A:A:E43	A:A:G42	1.64	No	No	0	9	8
1081	B:B:G141	B:B:Q176	1.64	No	Yes	0	5	4
1082	B:B:E260	B:B:G224	1.64	Yes	No	0	6	6
1083	A:A:N294	A:A:P282	1.63	No	Yes	0	3	5
1084	A:A:I19	B:B:A92	1.62	No	No	0	9	6
1085	A:A:A299	A:A:I278	1.62	No	No	0	7	6
1086	B:B:I33	G:G:A34	1.62	No	No	0	3	6
1087	B:B:I33	G:G:A35	1.62	No	No	0	3	2
1088	B:B:A92	B:B:I80	1.62	No	Yes	0	6	8
1089	R:R:A166	R:R:I170	1.62	No	No	0	3	4
1090	B:B:D38	B:B:P39	1.61	No	No	0	1	1
1091	R:R:A253	R:R:K250	1.61	No	No	0	7	6
1092	B:B:S31	B:B:T29	1.6	No	No	0	1	3
1093	B:B:S265	B:B:T249	1.6	No	Yes	1	2	6
1094	B:B:S265	B:B:T263	1.6	No	Yes	1	2	1
1095	R:R:V169	W:W:V48	1.6	No	No	0	4	0
1096	R:R:S226	R:R:T230	1.6	No	No	0	3	5
1097	W:W:V41	W:W:V45	1.6	No	Yes	0	0	0
1098	R:R:T312	R:R:V66	1.59	No	No	0	7	9
1099	R:R:T99	R:R:V96	1.59	Yes	No	0	6	5
1100	R:R:C287	R:R:L278	1.59	No	No	0	3	4
1101	W:W:C43	W:W:L42	1.59	No	No	0	0	0
1102	Z:Z:G48	Z:Z:H47	1.59	No	No	0	0	0
1103	G:G:A45	G:G:L51	1.58	No	Yes	0	4	6
1104	A:A:A12	B:B:N88	1.56	No	Yes	0	4	7
1105	A:A:C305	A:A:D309	1.56	No	No	0	3	4
1106	A:A:C325	A:A:D328	1.56	No	No	0	7	9
1107	G:G:A7	G:G:N5	1.56	No	No	0	4	4
1108	G:G:A23	G:G:N24	1.56	No	No	0	8	1
1109	A:A:I344	R:R:S232	1.55	No	No	0	6	5
1110	R:R:I185	R:R:S186	1.55	No	No	0	3	1
1111	R:R:I260	R:R:S263	1.55	No	No	0	6	5
1112	B:B:A28	B:B:D27	1.54	No	No	0	4	8
1113	R:R:I25	R:R:V26	1.54	Yes	No	0	4	6
1114	R:R:I53	R:R:V50	1.54	No	No	0	3	5
1115	R:R:I173	R:R:V169	1.54	No	No	0	4	4
1116	A:A:K17	A:A:V13	1.52	No	No	0	4	3
1117	B:B:A28	B:B:Q32	1.52	No	No	0	4	1
1118	W:W:M46	W:W:V49	1.52	No	No	0	0	0
1119	W:W:I51	W:W:T52	1.52	No	No	0	0	0
1120	B:B:L4	G:G:S8	1.5	No	No	0	4	4
1121	R:R:L102	R:R:S49	1.5	No	No	0	5	5
1122	R:R:K72	R:R:T73	1.5	No	No	0	6	6
1123	A:A:L5	A:A:V13	1.49	No	No	0	2	3
1124	B:B:L7	G:G:V16	1.49	Yes	Yes	0	8	7
1125	R:R:L47	R:R:V50	1.49	No	No	0	4	5
1126	R:R:L54	R:R:V50	1.49	No	No	0	4	5
1127	R:R:L54	R:R:V51	1.49	No	No	0	4	5
1128	R:R:L172	W:W:V49	1.49	No	No	0	4	0
1129	R:R:I259	R:R:I260	1.47	No	No	0	5	6
1130	R:R:L313	R:R:T312	1.47	No	No	0	6	7
1131	A:A:D200	A:A:V185	1.46	No	No	0	9	5
1132	A:A:I344	R:R:M149	1.46	No	Yes	0	6	8
1133	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
1134	A:A:E8	A:A:S6	1.44	No	No	0	5	7
1135	B:B:M217	G:G:M21	1.44	No	No	0	3	1
1136	Z:Z:E57	Z:Z:S56	1.44	No	No	0	0	0
1137	B:B:L7	G:G:I9	1.43	Yes	No	0	8	2
1138	R:R:I55	R:R:L302	1.43	No	No	0	6	6
1139	R:R:I59	R:R:L302	1.43	Yes	No	0	7	6
1140	R:R:L172	W:W:I53	1.43	No	No	0	4	0
1141	R:R:I37	R:R:N36	1.42	No	No	0	1	4
1142	A:A:K10	A:A:L5	1.41	No	No	0	3	2
1143	R:R:D23	R:R:I24	1.4	No	Yes	0	7	4
1144	A:A:D26	A:A:K29	1.38	No	No	0	5	1
1145	G:G:L15	G:G:L19	1.38	No	No	0	2	9
1146	R:R:L103	R:R:L104	1.38	No	No	0	6	4
1147	R:R:L162	R:R:L163	1.38	No	No	0	3	6
1148	R:R:L212	R:R:L213	1.38	No	No	0	5	8
1149	W:W:L61	Z:Z:N61	1.37	No	No	0	0	0
1150	A:A:K330	A:A:Q333	1.36	No	Yes	0	4	5
1151	B:B:N35	B:B:N36	1.36	No	No	0	1	1
1152	B:B:D76	B:B:L55	1.36	Yes	No	0	9	6
1153	W:W:L54	Z:Z:D55	1.36	No	No	0	0	0
1154	A:A:E276	A:A:K280	1.35	No	No	0	5	1
1155	A:A:E245	A:A:L234	1.33	No	No	0	9	8
1156	R:R:E62	R:R:L61	1.33	Yes	No	0	8	4
1157	Z:Z:E46	Z:Z:N42	1.31	No	No	0	0	0
1158	A:A:D26	A:A:E25	1.3	No	No	0	5	4
1159	R:R:F322	R:R:T69	1.3	No	No	0	7	8
1160	R:R:R231	R:R:T230	1.29	No	No	0	7	5
1161	B:B:Q13	B:B:Q9	1.28	No	No	0	1	3
1162	B:B:E12	B:B:Q13	1.27	No	No	0	4	1
1163	R:R:F273	R:R:I274	1.26	Yes	No	0	6	5
1164	G:G:E47	G:G:H44	1.23	No	No	0	3	6
1165	R:R:F158	R:R:N156	1.21	No	No	0	4	7
1166	R:R:L252	R:R:Y225	1.17	No	Yes	0	5	6
1167	B:B:E130	B:B:R129	1.16	No	No	0	3	3
1168	B:B:R283	G:G:E42	1.16	Yes	No	0	9	1
1169	B:B:R49	G:G:R62	1.07	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:V34	5.58667	6	11	5
2	A:A:K46	3.66	4	22	9
3	A:A:I184	4.835	4	1	9
4	A:A:F189	7.515	4	0	9
5	A:A:F191	7.1225	4	23	5
6	A:A:F196	7.644	5	11	7
7	A:A:M198	4.7	5	0	7
8	A:A:F199	9.026	5	1	5
9	A:A:V201	4.4	4	1	9
10	A:A:Q204	4.495	4	1	9
11	A:A:E207	4.8025	4	1	9
12	A:A:R208	5.115	4	1	9
13	A:A:K210	6.57167	6	1	9
14	A:A:W211	4.155	6	1	9
15	A:A:I212	4.45	4	1	8
16	A:A:H213	6.8725	4	1	8
17	A:A:C214	5.07	4	1	7
18	A:A:F215	5.02714	7	1	9
19	A:A:F223	5.918	5	0	9
20	A:A:V225	4.892	5	0	7
21	A:A:S228	5.6675	4	7	9
22	A:A:D229	6.985	4	7	8
23	A:A:Y230	7.3625	4	7	8
24	A:A:D231	9.3675	4	7	9
25	A:A:M243	3.3525	4	6	8
26	A:A:F250	6.83833	6	8	9
27	A:A:C254	5.548	5	8	5
28	A:A:N255	6.9425	4	8	8
29	A:A:W258	7.212	5	1	5
30	A:A:I265	3.3025	4	0	8
31	A:A:L266	4.318	5	12	9
32	A:A:F267	5.158	5	18	9
33	A:A:L268	5.406	5	12	8
34	A:A:F274	5.035	4	0	9
35	A:A:P282	3.45	4	0	5
36	A:A:C286	5.695	4	6	6
37	A:A:Y287	9.392	5	6	7
38	A:A:Y290	9.4525	4	6	7
39	A:A:Y296	5.61	4	0	4
40	A:A:E298	5.1525	4	6	4
41	A:A:Y302	9.9325	4	6	6
42	A:A:Q304	8.3075	4	12	5
43	A:A:F307	5.7325	4	0	8
44	A:A:N311	5.09	4	8	8
45	A:A:Y320	7.03	6	13	7
46	A:A:T321	7.875	4	12	5
47	A:A:T324	7.0175	4	18	9
48	A:A:Q333	4.1925	4	23	5
49	A:A:F336	6.505	4	0	8
50	A:A:D337	4.5925	4	0	4
51	A:A:D341	8.05	4	13	8
52	A:A:L348	4.015	4	9	9
53	A:A:L353	4.8975	4	9	7
54	B:B:L7	2.91	4	0	8
55	B:B:I18	4	4	1	7
56	B:B:L30	5.13	4	0	5
57	B:B:T34	4.84	4	1	5
58	B:B:I37	3.885	4	1	2
59	B:B:V40	4.27667	6	1	3
60	B:B:I43	4.1375	4	1	3
61	B:B:M45	4.676	5	1	4
62	B:B:L51	7.5225	4	5	9
63	B:B:H54	8.36429	7	5	9
64	B:B:Y59	9.862	5	1	8
65	B:B:W63	8.8	5	0	7
66	B:B:R68	11.595	4	0	5
67	B:B:V71	4.0875	4	3	8
68	B:B:D76	5.38	5	5	9
69	B:B:K78	6.5675	4	5	8
70	B:B:I80	9.7175	4	5	8
71	B:B:I81	4.2625	4	3	7
72	B:B:W82	9.42	7	5	9
73	B:B:N88	5.57	5	21	7
74	B:B:K89	6.63143	7	5	9
75	B:B:H91	5.275	4	3	5
76	B:B:I93	5.79	4	3	7
77	B:B:L95	5.152	5	3	8
78	B:B:W99	8.21857	7	1	9
79	B:B:Y105	4.96667	6	3	6
80	B:B:N110	6.515	4	10	4
81	B:B:Y111	6.098	5	10	4
82	B:B:V112	4.5875	4	3	8
83	B:B:C114	5.0375	4	3	8
84	B:B:L117	4.2475	4	1	9
85	B:B:N119	4.6675	4	1	9
86	B:B:I123	4.76	4	0	6
87	B:B:Y124	4.81571	7	3	6
88	B:B:L126	4.5575	4	3	5
89	B:B:V133	5.755	4	3	4
90	B:B:E138	6.2	4	3	6
91	B:B:H142	5.90429	7	1	9
92	B:B:Y145	5.6325	8	1	8
93	B:B:L146	4.025	4	1	7
94	B:B:C149	3.706	5	1	8
95	B:B:F151	4.46667	6	0	9
96	B:B:L152	4.7975	4	4	3
97	B:B:I157	4.106	5	1	7
98	B:B:T159	5.375	6	1	9
99	B:B:S160	4.4475	4	4	6
100	B:B:D163	7.615	4	1	9
101	B:B:C166	3.796	5	4	8
102	B:B:W169	9.76	5	1	8
103	B:B:Q176	7.53	4	0	4
104	B:B:F180	8.856	5	4	7
105	B:B:H183	6.85714	7	4	9
106	B:B:D186	6.208	5	1	9
107	B:B:V187	5.024	5	4	9
108	B:B:F199	7.326	5	4	9
109	B:B:V200	6.215	4	1	6
110	B:B:S201	4.915	4	4	9
111	B:B:C204	4.25	6	1	7
112	B:B:D205	7.14	4	4	9
113	B:B:K209	11.0675	4	4	6
114	B:B:L210	4.868	5	0	5
115	B:B:W211	8.47	6	4	8
116	B:B:Q220	8.04	4	1	7
117	B:B:F222	8.5475	4	1	8
118	B:B:H225	9.435	6	1	9
119	B:B:D228	5.92667	6	1	9
120	B:B:I232	4.71	4	1	8
121	B:B:F234	4.57	5	1	5
122	B:B:F235	5.94286	7	1	6
123	B:B:P236	5.295	4	1	7
124	B:B:F241	7.43333	6	1	6
125	B:B:T243	6.9625	4	1	8
126	B:B:D246	4.25	4	1	9
127	B:B:D247	6.396	5	1	9
128	B:B:T249	4.61	4	1	6
129	B:B:R251	10.09	5	1	8
130	B:B:F253	8.08	5	1	6
131	B:B:D254	4.69	4	0	9
132	B:B:D258	10.7375	4	1	7
133	B:B:E260	7.805	4	1	6
134	B:B:M262	5.38	4	1	4
135	B:B:T263	3.1825	4	1	1
136	B:B:Y264	6.97833	6	1	5
137	B:B:I269	4.6825	4	1	4
138	B:B:F278	5.40571	7	1	7
139	B:B:R283	6.20143	7	1	9
140	B:B:Y289	6.51	7	1	7
141	B:B:D290	8.0875	4	1	6
142	B:B:N295	5.8825	4	1	6
143	B:B:V296	4.0075	4	0	5
144	B:B:D298	8.8625	4	1	9
145	B:B:L300	5.835	4	1	6
146	B:B:R304	4.266	5	1	5
147	B:B:L308	8.855	4	1	7
148	B:B:H311	9.716	5	1	9
149	B:B:L318	4.5875	4	25	6
150	B:B:W332	11.1786	7	1	9
151	B:B:D333	7.8	4	1	9
152	B:B:L336	4.332	5	5	7
153	B:B:K337	7.218	5	1	6
154	B:B:W339	7.1	6	1	9
155	B:B:N340	6.6225	4	0	9
156	G:G:V16	4.098	5	20	7
157	G:G:K20	4.5025	4	20	6
158	G:G:R27	5.4	5	1	8
159	G:G:Y40	10.1825	4	1	6
160	G:G:D48	6.24333	6	1	9
161	G:G:L50	4.3325	4	1	9
162	G:G:L51	3.67667	6	1	6
163	G:G:P60	7.8675	4	5	9
164	G:G:F61	4.99571	7	5	8
165	R:R:I24	2.5025	4	0	4
166	R:R:I25	3.895	4	2	4
167	R:R:H28	5.2675	4	0	8
168	R:R:Y29	6.3225	4	2	7
169	R:R:T32	3.695	4	2	8
170	R:R:F52	7.86333	6	14	6
171	R:R:C56	2.7375	4	0	5
172	R:R:I59	4.01667	6	15	7
173	R:R:E62	6.12	4	0	8
174	R:R:N63	8.0325	4	15	9
175	R:R:K75	6.62667	6	16	6
176	R:R:Y81	9.2575	4	16	9
177	R:R:F83	5.2225	4	0	8
178	R:R:N86	6.6075	4	0	9
179	R:R:L87	4.125	4	9	9
180	R:R:D91	8.374	5	15	9
181	R:R:Y98	6.90333	6	0	6
182	R:R:T99	2	4	0	6
183	R:R:N101	7.1475	4	2	5
184	R:R:T113	4.985	4	0	7
185	R:R:W117	6.53375	8	2	9
186	R:R:F118	6.232	5	2	6
187	R:R:R120	7.45667	6	2	6
188	R:R:E121	7.03	5	2	5
189	R:R:F133	6.04	5	0	5
190	R:R:I138	4.4425	4	9	8
191	R:R:E141	6.3925	4	0	9
192	R:R:R142	7.576	5	9	9
193	R:R:Y143	7.9625	4	0	8
194	R:R:M149	5.25	4	0	8
195	R:R:L151	3.875	4	11	4
196	R:R:F161	4.97	4	29	2
197	R:R:I164	4.865	4	0	7
198	R:R:W168	4.98	4	0	9
199	R:R:P178	7.49	4	2	5
200	R:R:V194	4.13	4	2	4
201	R:R:L195	4.65	5	2	3
202	R:R:P196	5.6075	4	2	3
203	R:R:L197	8.885	4	2	4
204	R:R:Y198	7.19429	7	2	4
205	R:R:Y202	7.296	5	2	7
206	R:R:Y221	4.9975	4	9	9
207	R:R:Y225	5.61	5	0	6
208	R:R:L235	3.345	4	13	6
209	R:R:F237	4.8	4	13	3
210	R:R:L254	3.578	5	9	8
211	R:R:W269	9.672	5	28	8
212	R:R:F273	4.8925	4	0	6
213	R:R:L290	3.62	4	2	3
214	R:R:Y295	8.2275	4	14	3
215	R:R:Y311	4.5375	8	9	9
216	R:R:N315	6.77	4	16	8
217	R:R:M318	8.4	4	16	8
218	W:W:V45	3.285	4	29	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:K46	A:A:L38	85.6444	2.82	Yes	No	0	9	8
2	A:A:K46	A:A:S44	85.9289	3.06	Yes	No	22	9	9
3	A:A:G40	A:A:S44	88.1142	1.86	No	No	0	9	9
4	A:A:F223	A:A:G40	88.1997	4.52	Yes	No	0	9	9
5	A:A:F223	A:A:L249	100	4.87	Yes	No	0	9	9
6	A:A:L249	A:A:R208	99.9179	4.86	No	Yes	0	9	9
7	A:A:I212	A:A:R208	27.1316	5.01	Yes	Yes	1	8	9
8	A:A:I212	A:A:N256	28.0499	4.25	Yes	No	1	8	8
9	A:A:N256	A:A:W258	28.0156	3.39	No	Yes	1	8	5
10	A:A:W258	B:B:W332	27.8989	3.75	Yes	Yes	1	5	9
11	B:B:S316	B:B:W332	16.1009	6.18	No	Yes	0	9	9
12	B:B:C317	B:B:S316	15.9055	3.44	No	No	0	7	9
13	B:B:C317	B:B:M61	15.534	4.86	No	No	0	7	6
14	A:A:I222	A:A:L38	76.5276	5.71	No	No	0	7	8
15	A:A:F215	A:A:W211	11.3561	4.01	Yes	Yes	1	9	9
16	A:A:I222	A:A:I265	72.4473	2.94	No	Yes	0	7	8
17	A:A:W211	B:B:Y145	74.8145	2.89	Yes	Yes	1	9	8
18	A:A:K210	B:B:Y145	78.8834	3.58	Yes	Yes	1	9	8
19	B:B:R314	B:B:W332	20.7285	20.99	No	Yes	1	8	9
20	B:B:D290	B:B:R314	12.3472	21.44	Yes	No	1	6	8
21	A:A:K210	B:B:D228	76.476	6.91	Yes	Yes	1	9	9
22	A:A:F223	A:A:V225	17.4043	2.62	Yes	Yes	0	9	7
23	A:A:F223	A:A:L266	11.1491	3.65	Yes	Yes	0	9	9
24	A:A:F274	A:A:L227	13.9523	7.31	Yes	No	0	9	7
25	A:A:L227	A:A:L268	14.3514	5.54	No	Yes	0	7	8
26	A:A:A338	A:A:I265	72.1541	3.25	No	Yes	0	6	8
27	A:A:A338	A:A:Y320	72.0501	6.67	No	Yes	0	6	7
28	A:A:D341	A:A:Y320	70.9614	12.64	Yes	Yes	13	8	7
29	A:A:D341	A:A:K345	76.3172	9.68	Yes	No	0	8	5
30	A:A:F354	A:A:K345	76.2029	3.72	No	No	0	5	5
31	A:A:F354	A:A:L348	76.2779	4.87	No	Yes	0	5	9
32	A:A:L348	A:A:L353	70.204	2.77	Yes	Yes	9	9	7
33	A:A:L353	R:R:R142	70.2405	9.72	Yes	Yes	9	7	9
34	R:R:R142	R:R:Y311	54.8767	8.23	Yes	Yes	9	9	9
35	R:R:L135	R:R:Y311	50.8905	4.69	No	Yes	0	9	9
36	R:R:F265	R:R:L135	50.4006	4.87	No	No	0	9	9
37	R:R:F265	R:R:W269	49.969	7.02	No	Yes	0	9	8
38	R:R:L128	R:R:W269	51.9678	7.97	No	Yes	0	6	8
39	R:R:L128	R:R:M124	51.8044	4.24	No	No	0	6	6
40	R:R:M124	R:R:Y98	23.5681	7.18	No	Yes	0	6	6
41	R:R:V301	R:R:Y98	15.3467	5.05	No	Yes	0	7	6
42	R:R:I59	R:R:V301	15.1401	3.07	Yes	No	0	7	7
43	R:R:P308	R:R:V66	12.1141	7.07	No	No	0	9	9
44	R:R:T312	R:R:V66	10.3939	1.59	No	No	0	7	9
45	B:B:I18	G:G:R27	40.0824	3.76	Yes	Yes	1	7	8
46	B:B:I18	G:G:A23	21.0319	3.25	Yes	No	0	7	8
47	B:B:Q17	G:G:A23	19.4795	3.03	No	No	0	4	8
48	B:B:L14	B:B:Q17	18.7029	3.99	No	No	0	8	4
49	B:B:L14	G:G:K20	13.2608	2.82	No	Yes	0	8	6
50	G:G:K20	G:G:V16	10.9222	3.04	Yes	Yes	20	6	7
51	B:B:I18	G:G:E22	53.4322	2.73	Yes	No	0	7	9
52	B:B:D258	G:G:R27	37.1452	13.1	Yes	Yes	1	7	8
53	B:B:G162	B:B:Y145	17.5722	4.35	No	Yes	1	9	8
54	B:B:G162	B:B:S161	23.9299	3.71	No	No	1	9	9
55	B:B:H142	B:B:S161	22.8767	16.74	Yes	No	1	9	9
56	B:B:H142	B:B:W169	11.4482	3.17	Yes	Yes	1	9	8
57	B:B:D118	B:B:I120	10.3623	8.4	No	No	0	9	6
58	B:B:D118	B:B:S97	10.7271	10.31	No	No	0	9	8
59	B:B:T221	G:G:E22	30.9796	9.88	No	No	0	7	9
60	B:B:K209	B:B:T221	30.2094	13.51	Yes	No	0	6	7
61	B:B:K209	B:B:W211	20.1423	6.96	Yes	Yes	4	6	8
62	B:B:F180	B:B:W211	21.7024	15.03	Yes	Yes	4	7	8
63	B:B:F180	B:B:T178	17.0669	9.08	Yes	No	4	7	4
64	G:G:E22	G:G:Q18	21.6857	10.19	No	No	0	9	9
65	B:B:C218	G:G:Q18	20.9169	6.1	No	No	0	5	9
66	B:B:C218	B:B:W211	20.146	5.22	No	Yes	4	5	8
67	B:B:F199	B:B:W211	13.9509	13.03	Yes	Yes	4	9	8
68	B:B:T177	B:B:T178	10.8618	4.71	No	No	4	4	4
69	B:B:D247	B:B:S227	84.0621	2.94	Yes	No	1	9	6
70	B:B:D247	B:B:H225	56.7896	6.3	Yes	Yes	1	9	9
71	B:B:H225	B:B:T243	30.1819	10.95	Yes	Yes	1	9	8
72	B:B:F253	B:B:T243	25.7397	7.78	Yes	Yes	1	6	8
73	B:B:H225	B:B:R251	26.2077	14.67	Yes	Yes	1	9	8
74	B:B:F253	B:B:R251	51.3645	3.21	Yes	Yes	1	6	8
75	B:B:D247	B:B:T249	26.98	7.23	Yes	Yes	1	9	6
76	B:B:R251	B:B:T249	26.184	6.47	Yes	Yes	1	8	6
77	B:B:F222	B:B:F253	72.7204	11.79	Yes	Yes	1	8	6
78	B:B:C271	B:B:D290	12.8602	4.67	No	Yes	1	5	6
79	B:B:C271	B:B:Y289	12.1217	4.03	No	Yes	1	5	7
80	B:B:W297	B:B:Y289	10.3428	6.75	No	Yes	1	8	7
81	B:B:W297	B:B:Y264	10.433	12.54	No	Yes	1	8	5
82	B:B:L318	B:B:S275	11.5459	7.51	Yes	No	0	6	8
83	R:R:M124	R:R:N101	31.9354	2.8	No	Yes	0	6	5
84	R:R:N101	R:R:R120	11.6847	13.26	Yes	Yes	2	5	6
85	R:R:R120	R:R:W117	10.9283	7	Yes	Yes	2	6	9
86	R:R:E121	R:R:N101	19.6611	6.57	Yes	Yes	2	5	5
87	R:R:E121	R:R:W117	10.8693	9.81	Yes	Yes	2	5	9
88	R:R:I138	R:R:R142	15.1326	7.52	Yes	Yes	9	8	9
89	R:R:F83	R:R:I138	12.8102	3.77	Yes	Yes	0	8	8
90	R:R:F83	R:R:I164	11.3184	5.02	Yes	Yes	0	8	7
91	A:A:R208	A:A:W211	72.8782	4	Yes	Yes	1	9	9
92	B:B:S97	B:B:W99	11.1055	3.71	No	Yes	0	8	9
93	B:B:D228	B:B:S227	80.2255	7.36	Yes	No	1	9	6
94	B:B:D258	B:B:F222	72.0098	3.58	Yes	Yes	1	7	8
95	B:B:D258	B:B:R22	35.1128	11.91	Yes	No	1	7	6
96	B:B:I18	B:B:R22	34.7359	6.26	Yes	No	1	7	6
97	B:B:S275	B:B:T274	11.742	4.8	No	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P79	R:R:S155	5.34	27	No	No	7	7	2	2
R:R:N157	R:R:P79	3.26	27	No	No	1	7	1	2
R:R:F83	R:R:I164	5.02	0	Yes	Yes	8	7	2	1
R:R:I164	R:R:N86	5.66	0	Yes	Yes	7	9	1	2
R:R:F118	R:R:I179	6.28	2	Yes	No	6	5	2	1
R:R:F118	R:R:N183	9.67	2	Yes	No	6	5	2	2
R:R:L172	R:R:V126	4.47	0	No	No	4	5	1	2
R:R:N157	R:R:S155	5.96	27	No	No	1	7	1	2
R:R:N157	W:W:V41	4.43	27	No	No	1	0	1	0
R:R:I164	R:R:L160	5.71	0	Yes	No	7	7	1	2
R:R:F161	R:R:S165	9.25	29	Yes	No	2	4	1	1
R:R:F161	W:W:A44	2.77	29	Yes	No	2	0	1	0
R:R:F161	W:W:V45	5.24	29	Yes	Yes	2	0	1	0
R:R:F161	W:W:V48	2.62	29	Yes	No	2	0	1	0
R:R:I164	W:W:V45	3.07	0	Yes	Yes	7	0	1	0
R:R:S165	W:W:V45	3.23	29	No	Yes	4	0	1	0
R:R:V169	W:W:T52	7.93	0	No	No	4	0	1	0
R:R:L177	R:R:M180	2.83	0	No	No	5	4	2	1
R:R:I179	W:W:A60	3.25	0	No	No	5	0	1	0
R:R:M180	W:W:I56	5.83	0	No	No	4	0	1	0
R:R:M180	W:W:I59	10.2	0	No	No	4	0	1	0
R:R:G181	R:R:N183	5.09	0	No	No	5	5	1	2
R:R:G181	W:W:V63	1.84	0	No	No	5	0	1	0
R:R:V169	W:W:V48	1.6	0	No	No	4	0	1	0
R:R:I173	R:R:V169	1.54	0	No	No	4	4	2	1
R:R:L172	W:W:V49	1.49	0	No	No	4	0	1	0
R:R:L172	W:W:I53	1.43	0	No	No	4	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
25.00	Single	6KQI	Org27569	6KQI-CB₁-CP55940-Org27569
21.43	Single	5NDZ	AZ3451; Na	5NDZ-PAR2-AZ3451; Na
12.50	Single	8T3V	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11	Single	8Y73	MPAM-15	8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
10.00	Single	7WU4	K6G	7WU4-ADGRF1-K6G-Gi1/β1/γ2
10.00	Single	9CLW	TUG-1375	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52	Single	9CM3	TUG-1375	9CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
8.70	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.70	Single	9CM7	TUG-1375	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
8.70	Single	9NS9	TUG-1375	9NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
8.33	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
7.14	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
6.67	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
6.67	Single	8EIT	Doconexent	8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25	Single	6HLL	CP99994	6HLL-NK₁-CP99994
6.25	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
6.25	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
6.25	Single	7FEE	ZCZ011	7FEE-CB₁-CP55940-ZCZ011
6.25	Single	8IKH	Q2L	8IKH-CB₁-Q2L-Gi1/β1/γ1
5.88	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
5.88	Single	5WS3	EMPA	5WS3-OX₂-EMPA
5.88	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
5.88	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
5.88	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
5.88	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
5.88	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
5.88	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
5.88	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
5.88	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
5.88	Single	8G2Y	LPC	8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/β1/γ2
5.88	Single	8IW4	Spermidine	8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8IWE	Spermidine	8IWE-TA9-Spermidine
5.88	Consensus	angiotensin_off	Orthosteric Ligand	at1_off
5.88	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
5.88	Consensus	ox1_off	Orthosteric Ligand	6TP6-OX₁-Filorexant 6TP4-OX₁-ACT-462206 6V9S-OX₁-GTPL11403 6TOT-OX₁-Lemborexant 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant 6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na
5.88	Consensus	ox2_off	Orthosteric Ligand	5WQC-OX₂-EMPA 6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant 6TPJ-OX₂-Suvorexant
5.56	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
5.56	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
5.56	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
5.56	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
5.56	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
5.56	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
5.56	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
5.56	Single	6TPK	Retosiban	6TPK-OT-Retosiban
5.56	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
5.56	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
5.56	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/β1/γ2
5.56	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
5.56	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
5.56	Single	8YRG	Fospropofol	8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	8ZMG	Pimavanserin	8ZMG-5-HT_2A-Pimavanserin
5.56	Single	9IXX	LTD4	9IXX-CysLT₂-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
5.56	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
5.56	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
5.26	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
5.26	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
5.26	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/β1/γ2
5.26	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/β1/γ2
5.26	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
5.26	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.26	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Single	9IYA	ONO-9710531	9IYA-GPR55-ONO-9710531
5.26	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.26	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.26	Consensus	blt_on	Orthosteric Ligand	blt1_on
5.26	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
5.26	Consensus	cck_off	Orthosteric Ligand	ccka_off
5.26	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
5.26	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.26	Consensus	gi_orexin	Orthosteric Ligand	7SQO-OX₂-TAK-925-Gi1/β1/γ2
5.26	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
5.26	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
5.00	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
5.00	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
5.00	Single	5WQC	EMPA	5WQC-OX₂-EMPA
5.00	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
5.00	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
5.00	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
5.00	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
5.00	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
5.00	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
5.00	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
5.00	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
5.00	Single	7W41	PD176252	7W41-BB₂-PD176252
5.00	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/β1/γ2
5.00	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.00	Single	8TH4	Losartan	8TH4-AT₁-Losartan-AT118-L Nanobody
5.00	Single	8ZMF	A1L10	8ZMF-5-HT_2C-A1L10
5.00	Single	9GE2	ML184	9GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
5.00	Single	9HAP	Tolvaptan	9HAP-V₂-Tolvaptan
5.00	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
5.00	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
5.00	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
4.76	Single	5TZR	MK8666	5TZR-FFA1-MK8666
4.76	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
4.76	Single	6E59	L-760735	6E59-NK₁-L-760735
4.76	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
4.76	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
4.76	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
4.76	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
4.76	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
4.76	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
4.76	Single	9JMC	DS-3801b	9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
4.76	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
4.76	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.76	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
4.76	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
4.76	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.76	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
4.76	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
4.76	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
4.55	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
4.55	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
4.55	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
4.55	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
4.55	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
4.55	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
4.55	Single	8Y6W	TUG-1375	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
4.55	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.55	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
4.55	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
4.55	Consensus	orexin_on	Orthosteric Ligand	ox2_on
4.35	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
4.35	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
4.35	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
4.35	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
4.35	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
4.35	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
4.35	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
4.35	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
4.35	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	9EAI	Losartan	9EAI-AT₁-Losartan-Nanobody AT209
4.35	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
4.35	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
4.35	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
4.35	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
4.35	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
4.35	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
4.35	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
4.17	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
4.17	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
4.17	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
4.17	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
4.17	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
4.17	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
4.17	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	9IPV	JR14a	9IPV-C3a_B-JR14a-Gi1/β1/γ2
4.17	Single	9IPY	JR14a	9IPY-C3a_B-JR14a
4.17	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	9JF4	PD168368	9JF4-BB₁-PD168368
4.17	Single	9JH6	C20:0 Ceramide	9JH6-CysLT₂-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	9V2N	Macimorelin	9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
4.17	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
4.00	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
4.00	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
4.00	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
4.00	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
4.00	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
4.00	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
4.00	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
4.00	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.00	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
4.00	Single	8WKY	PG-934	8WKY-MC₄-PG-934
4.00	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
4.00	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
4.00	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
4.00	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
4.00	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
3.85	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
3.85	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
3.85	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
3.85	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
3.85	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
3.85	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
3.85	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
3.85	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.85	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
3.85	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
3.85	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.85	Consensus	ghrelin_on	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
3.85	Consensus	ghrelin_on_gp	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
3.85	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.85	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
3.85	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.85	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
3.85	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
3.70	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
3.70	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
3.70	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
3.70	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
3.70	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
3.70	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Single	8W8Y	Gamma-MSH	8W8Y-MC₃-γ-MSH-Ca-Gs/β1/γ2
3.70	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
3.70	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.70	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.70	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
3.70	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.70	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
3.70	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
3.70	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.70	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.70	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
3.57	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
3.57	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
3.57	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
3.57	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
3.57	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.57	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.57	Consensus	mc5_on_gp	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.57	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
3.57	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
3.57	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
3.45	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
3.45	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.45	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.45	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
3.45	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.45	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
3.45	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.45	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.45	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.45	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
3.33	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.33	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
3.33	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
3.33	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.33	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
3.33	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
3.33	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
3.33	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.33	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.33	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
3.23	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
3.23	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
3.23	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
3.23	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.23	Single	8W8W	Alpha-MSH	8W8W-MC₃-α-MSH-Ca-Gs/β1/γ2
3.23	Single	8W8X	Beta-MSH	8W8X-MC₃-β-MSH-Ca-Gs/β1/γ2
3.23	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
3.23	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.23	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.23	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
3.23	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
3.12	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
3.12	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
3.03	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.03	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.03	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
3.03	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
3.03	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.03	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.03	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
3.03	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
2.94	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
2.94	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
2.94	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
2.86	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
2.78	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
2.63	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.63	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.27	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB	8G94
Class	A
SubFamily	Lipid
Type	Lysophospholipid
SubType	S1P1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	CD69
Protein Partners	Gi1/Beta1/Gamma2
PDB Resolution	3.15
Date	2023-04-19
D.O.I.	doi.org/10.7554/eLife.88204

Net Summary
I_min	2.62
Number of Linked Nodes	902
Number of Links	1169
Number of Hubs	218
Number of Links mediated by Hubs	757
Number of Communities	29
Number of Nodes involved in Communities	309
Number of Links involved in Communities	471

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	1699619
Length Of Smallest Path	3
Average Path Length	28.3002
Length of Longest Path	61
Minimum Path Strength	1.275
Average Path Strength	5.83532
Maximum Path Strength	22.68
Minimum Path Correlation	0.7
Average Path Correlation	0.984044
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.63158
Average % Of Corr. Nodes	46.7348
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	57.4725
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • response to stimulus • regulation of alpha-beta T cell activation • regulation of leukocyte activation • regulation of cell activation • regulation of cell development • alpha-beta T cell differentiation involved in immune response • negative regulation of cell adhesion • negative regulation of cell fate commitment • multicellular organism development • negative regulation of T cell differentiation • T cell activation • cell differentiation • regulation of T-helper cell differentiation • alpha-beta T cell activation • regulation of immune system process • immune response • T-helper cell differentiation • alpha-beta T cell lineage commitment • negative regulation of leukocyte differentiation • negative regulation of immune effector process • immune effector process • negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • negative regulation of T-helper 17 cell lineage commitment • regulation of response to stimulus • negative regulation of T cell activation • negative regulation of leukocyte cell-cell adhesion • negative regulation of cell-cell adhesion • regulation of leukocyte cell-cell adhesion • negative regulation of multicellular organismal process • T-helper 17 cell differentiation • cell fate commitment • CD4-positive or CD8-positive, alpha-beta T cell lineage commitment • regulation of developmental process • cell development • negative regulation of T-helper 17 cell differentiation • CD4-positive, alpha-beta T cell differentiation • regulation of T cell differentiation • alpha-beta T cell differentiation • T cell activation involved in immune response • leukocyte activation involved in immune response • negative regulation of cell differentiation • regulation of cell-cell adhesion • regulation of T-helper 17 cell differentiation • hemopoiesis • negative regulation of developmental process • regulation of cell adhesion • cell activation • negative regulation of T-helper 17 type immune response • negative regulation of cell development • regulation of CD4-positive, alpha-beta T cell activation • immune system process • cellular process • negative regulation of alpha-beta T cell activation • regulation of lymphocyte activation • regulation of immune effector process • multicellular organismal process • regulation of leukocyte differentiation • regulation of cellular process • negative regulation of biological process • mononuclear cell differentiation • regulation of cell differentiation • lymphocyte differentiation • cell activation involved in immune response • CD4-positive, alpha-beta T cell differentiation involved in immune response • anatomical structure development • T cell differentiation • CD4-positive, alpha-beta T cell lineage commitment • negative regulation of hemopoiesis • developmental process • regulation of biological process • regulation of adaptive immune response • negative regulation of immune response • T-helper cell lineage commitment • negative regulation of adaptive immune response • T-helper 17 cell lineage commitment • negative regulation of CD4-positive, alpha-beta T cell activation • negative regulation of lymphocyte differentiation • regulation of immune response • negative regulation of CD4-positive, alpha-beta T cell differentiation • negative regulation of leukocyte activation • leukocyte differentiation • cellular developmental process • regulation of CD4-positive, alpha-beta T cell differentiation • regulation of alpha-beta T cell differentiation • lymphocyte activation • negative regulation of alpha-beta T cell differentiation • negative regulation of lymphocyte activation • leukocyte cell-cell adhesion • leukocyte activation • cell adhesion • regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • cell-cell adhesion • alpha-beta T cell activation involved in immune response • CD4-positive, alpha-beta T cell activation • negative regulation of cellular process • regulation of multicellular organismal process • lymphocyte activation involved in immune response • regulation of lymphocyte differentiation • regulation of multicellular organismal development • regulation of T-helper 17 cell lineage commitment • regulation of T-helper 17 type immune response • negative regulation of response to stimulus • regulation of cell fate commitment • biological regulation • regulation of T cell activation • T cell differentiation involved in immune response • T cell lineage commitment • adaptive immune response • negative regulation of T-helper cell differentiation • negative regulation of cell activation • negative regulation of immune system process • positive T cell selection • regulation of hemopoiesis • T cell selection • T-helper 17 type immune response • cellular response to stimulus • cellular response to chemical stimulus • response to chemical • cellular response to xenobiotic stimulus • response to xenobiotic stimulus • negative regulation of mononuclear cell migration • negative regulation of locomotion • regulation of cell motility • regulation of lymphocyte migration • regulation of cell migration • cell migration • negative regulation of lymphocyte migration • cell motility • regulation of mononuclear cell migration • locomotion • negative regulation of cell migration • regulation of leukocyte migration • lymphocyte migration • leukocyte migration • negative regulation of T cell migration • negative regulation of leukocyte migration • regulation of locomotion • regulation of T cell migration • mononuclear cell migration • negative regulation of cell motility • T cell migration • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • protein-containing complex • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • sphingolipid binding • lipid binding • bioactive lipid receptor activity • sphingosine-1-phosphate receptor activity • head development • central nervous system development • brain development • nervous system development • lamellipodium assembly • plasma membrane bounded cell projection organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component biogenesis • cellular component assembly • lamellipodium organization • cell projection assembly • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of actin filament-based process • regulation of actin filament bundle assembly • actin filament bundle organization • actin filament-based process • stress fiber assembly • negative regulation of supramolecular fiber organization • regulation of actin filament organization • negative regulation of stress fiber assembly • actin cytoskeleton organization • actomyosin structure organization • negative regulation of cellular component organization • negative regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • negative regulation of actin filament bundle assembly • regulation of stress fiber assembly • negative regulation of organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • heart trabecula morphogenesis • trabecula morphogenesis • generation of neurons • neurogenesis • neuron differentiation • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • homeostatic process • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • bone mineralization • regulation of biomineral tissue development • regulation of bone mineralization • ossification • biomineral tissue development • regulation of ossification • chemotaxis • taxis • response to external stimulus • positive chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of positive chemotaxis • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • regulation of positive chemotaxis • positive regulation of response to external stimulus • transmission of nerve impulse • positive regulation of cell migration • positive regulation of cell motility • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • developmental growth • heart morphogenesis • organ growth • striated muscle tissue development • muscle structure development • cardiac muscle tissue growth involved in heart morphogenesis • animal organ morphogenesis • cardiac muscle tissue growth • muscle tissue development • muscle organ development • heart development • heart growth • cardiac muscle tissue development • growth • muscle tissue morphogenesis • developmental growth involved in morphogenesis • tissue morphogenesis • cardiac muscle tissue morphogenesis • growth involved in heart morphogenesis • muscle organ morphogenesis • cell chemotaxis • leukocyte chemotaxis • sphingolipid mediated signaling pathway • sphingosine-1-phosphate receptor signaling pathway • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • blood vessel maturation • developmental maturation • anatomical structure maturation • membrane microdomain • membrane raft • presynapse • endosome • intracellular vesicle • cytoplasmic vesicle
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63096
Sequence	>8G94_Chain_A T L S A E D K A A V E R S K M I D R N L R E D G E K A A R E V K L L L L G A G E S G K S T I V K Q M K I T G I V E T H F T F K D L H F K M F D V G A Q R S E R K K W I H C F E G V T A I I F C V A L S D Y D L V L A M N R M H E S M K L F D S I C N N K W F T D T S I I L F L N K K D L F E E K I K K S P L T I C Y P E Y A G S N T Y E E A A A Y I Q C Q F E D L N K R K D T K E I Y T H F T C S T D T K N V Q F V F D A V T D V I I K N N L K D C G L F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8G94_Chain_B L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8G94_Chain_G N T A S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>8G94_Chain_R V N Y D I I V R H Y N Y T G K L N I K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K M K L H N G S N N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F R K K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	doi.org/10.7554/eLife.88204
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-	Gi1/β1/γ2	2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-		2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-		2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published

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