Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I24 2.5025404
2R:R:I25 3.895434
3R:R:H28 5.2675408
4R:R:Y29 6.3225437
5R:R:T32 3.695438
6R:R:F52 7.863336156
7R:R:C56 2.7375405
8R:R:I59 4.016676167
9R:R:E62 6.12408
10R:R:N63 8.03254169
11R:R:K75 6.626676176
12R:R:Y81 9.25754179
13R:R:F83 5.2225408
14R:R:N86 6.6075409
15R:R:L87 4.125489
16R:R:D91 8.3745169
17R:R:Y98 6.90333606
18R:R:T99 2406
19R:R:N101 7.1475435
20R:R:T113 4.985407
21R:R:W117 6.53375839
22R:R:F118 6.232536
23R:R:R120 7.45667636
24R:R:E121 7.03535
25R:R:F133 6.04505
26R:R:I138 4.4425488
27R:R:E141 6.3925409
28R:R:R142 7.576589
29R:R:Y143 7.9625408
30R:R:M149 5.25408
31R:R:L151 3.8754124
32R:R:F161 4.974232
33R:R:I164 4.865407
34R:R:W168 4.98409
35R:R:P178 7.49435
36R:R:V194 4.13434
37R:R:L195 4.65533
38R:R:P196 5.6075433
39R:R:L197 8.885434
40R:R:Y198 7.19429734
41R:R:Y202 7.296537
42R:R:Y221 4.9975489
43R:R:Y225 5.61506
44R:R:L235 3.3454136
45R:R:F237 4.84133
46R:R:L254 3.578588
47R:R:W269 9.6725118
48R:R:F273 4.4325116
49R:R:L290 3.62433
50R:R:Y295 8.22754153
51R:R:Y311 4.5375889
52R:R:N315 6.774178
53R:R:M318 8.44178
54A:A:V34 5.586676125
55A:A:K46 3.664249
56A:A:I184 4.835419
57A:A:F189 7.515409
58A:A:F191 7.12254255
59A:A:F196 7.6445127
60A:A:M198 4.7507
61A:A:F199 9.026515
62A:A:V201 4.4419
63A:A:Q204 4.495419
64A:A:E207 4.8025419
65A:A:R208 5.115419
66A:A:K210 6.57167619
67A:A:W211 4.155619
68A:A:I212 4.45418
69A:A:H213 6.8725418
70A:A:C214 4.578517
71A:A:F215 5.02714719
72A:A:F223 5.918509
73A:A:V225 4.892507
74A:A:S228 5.6675479
75A:A:D229 6.985478
76A:A:Y230 6.398578
77A:A:D231 9.3675479
78A:A:M243 3.3525468
79A:A:F250 6.83833699
80A:A:C254 5.548595
81A:A:N255 6.9425498
82A:A:W258 7.212515
83A:A:I265 3.3025408
84A:A:L266 4.3185149
85A:A:F267 5.1585209
86A:A:L268 5.4065148
87A:A:F274 5.035409
88A:A:P282 3.45405
89A:A:C286 5.695466
90A:A:Y287 9.392567
91A:A:Y290 9.4525467
92A:A:Y296 5.61404
93A:A:E298 5.1525464
94A:A:Y302 9.9325466
95A:A:Q304 8.30754145
96A:A:F307 5.7325408
97A:A:N311 5.09498
98A:A:Y320 7.036137
99A:A:T321 7.8754145
100A:A:H322 9.24254209
101A:A:T324 7.01754209
102A:A:N331 7.7054208
103A:A:Q333 4.19254255
104A:A:F336 6.505408
105A:A:D337 4.5925404
106A:A:D341 8.054138
107A:A:L348 4.015489
108A:A:L353 4.8975487
109B:B:L7 2.91408
110B:B:I18 4417
111B:B:L30 5.13405
112B:B:T34 4.84415
113B:B:I37 3.885412
114B:B:V40 4.27667613
115B:B:I43 4.1375413
116B:B:M45 4.676514
117B:B:R49 3.5025427
118B:B:L51 7.5225429
119B:B:H54 8.36429729
120B:B:Y59 9.862518
121B:B:W63 8.8507
122B:B:R68 11.595425
123B:B:V71 4.0875448
124B:B:D76 5.38529
125B:B:K78 6.5675428
126B:B:I80 9.7175428
127B:B:I81 4.2625447
128B:B:W82 9.42729
129B:B:S84 4.16425
130B:B:Y85 12.09424
131B:B:N88 5.57527
132B:B:K89 6.63143729
133B:B:H91 5.275445
134B:B:I93 5.79447
135B:B:L95 5.152548
136B:B:W99 7.5175819
137B:B:Y105 4.96667646
138B:B:N110 6.5154104
139B:B:Y111 6.0985104
140B:B:V112 4.5875448
141B:B:C114 5.0375448
142B:B:L117 4.2475419
143B:B:N119 4.6675419
144B:B:I123 4.76406
145B:B:Y124 4.81571746
146B:B:L126 4.5575445
147B:B:V133 5.755444
148B:B:E138 6.2446
149B:B:H142 5.90429719
150B:B:Y145 5.28889918
151B:B:L146 4.025417
152B:B:C149 3.706518
153B:B:F151 4.46667609
154B:B:L152 4.7975453
155B:B:I157 4.106517
156B:B:T159 5.375619
157B:B:S160 4.4475456
158B:B:D163 7.615419
159B:B:C166 3.796558
160B:B:W169 8.565618
161B:B:Q176 7.53414
162B:B:F180 8.856557
163B:B:H183 6.85714759
164B:B:D186 6.208519
165B:B:V187 5.024559
166B:B:F199 7.326559
167B:B:V200 6.215416
168B:B:S201 4.915459
169B:B:C204 4.25617
170B:B:D205 7.14459
171B:B:K209 11.0675456
172B:B:L210 4.868505
173B:B:W211 8.47658
174B:B:Q220 8.04417
175B:B:F222 8.5475418
176B:B:H225 9.435619
177B:B:D228 5.92667619
178B:B:I232 4.71418
179B:B:F234 4.57515
180B:B:F235 5.94286716
181B:B:P236 5.295417
182B:B:F241 6.74143716
183B:B:T243 6.088518
184B:B:D246 4.25419
185B:B:D247 6.396519
186B:B:T249 4.61416
187B:B:R251 10.09518
188B:B:F253 8.08516
189B:B:D254 4.69409
190B:B:D258 10.7375417
191B:B:E260 7.805416
192B:B:M262 5.38414
193B:B:T263 3.1825411
194B:B:Y264 6.97833615
195B:B:I269 4.6825414
196B:B:F278 5.40571717
197B:B:R283 6.20143719
198B:B:Y289 6.51717
199B:B:D290 8.0875416
200B:B:N295 5.8825416
201B:B:V296 4.0075405
202B:B:W297 6.6418
203B:B:D298 8.8625419
204B:B:L300 5.835416
205B:B:R304 4.266515
206B:B:L308 8.855417
207B:B:H311 9.716519
208B:B:L318 4.58754276
209B:B:W332 11.1786719
210B:B:D333 7.8419
211B:B:L336 4.332527
212B:B:K337 7.218516
213B:B:W339 7.1619
214B:B:N340 6.6225409
215G:G:V16 4.0985217
216G:G:K20 4.50254216
217G:G:R27 5.4518
218G:G:Y40 10.1825416
219G:G:D48 6.24333619
220G:G:L50 4.3325419
221G:G:L51 3.67667616
222G:G:P60 7.8675429
223G:G:F61 4.99571728
224W:W:V45 3.2854230
225W:W:I51 2.5625400
226X:X:E57 2.445400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:H28 R:R:L197 10.82177.71YesYes084
2R:R:L197 R:R:W117 11.255314.81YesYes349
3R:R:R120 R:R:W117 14.04867YesYes369
4R:R:N101 R:R:R120 14.97913.26YesYes356
5R:R:M124 R:R:N101 41.30712.8NoYes065
6R:R:M124 R:R:Y98 30.58817.18NoYes066
7R:R:E121 R:R:W117 13.9369.81YesYes359
8R:R:E121 R:R:N101 25.58746.57YesYes355
9R:R:V301 R:R:Y98 20.01395.05NoYes076
10R:R:I59 R:R:V301 19.74763.07YesNo077
11R:R:P308 R:R:V66 15.88437.07NoNo099
12R:R:T312 R:R:V66 13.63381.59NoNo079
13R:R:M318 R:R:T312 11.37717.53YesNo087
14R:R:L128 R:R:M124 65.04324.24NoNo066
15R:R:L128 R:R:W269 65.23127.97NoYes068
16R:R:F265 R:R:W269 60.38337.02NoYes098
17R:R:F265 R:R:L135 60.84484.87NoNo099
18R:R:L135 R:R:Y311 61.2034.69NoYes099
19R:R:R142 R:R:Y311 64.54098.23YesYes899
20A:A:L353 R:R:R142 82.23899.72YesYes879
21A:A:L348 A:A:L353 81.86432.77YesYes897
22A:A:F354 A:A:L348 88.91444.87NoYes059
23A:A:F354 A:A:K345 88.6783.72NoNo055
24A:A:D341 A:A:K345 88.77939.68YesNo085
25A:A:D341 A:A:Y320 78.993412.64YesYes1387
26A:A:A338 A:A:Y320 80.11926.67NoYes067
27A:A:A338 A:A:I265 80.20243.25NoYes068
28A:A:I222 A:A:I265 80.49742.94NoYes078
29A:A:I222 A:A:L38 84.81755.71NoNo078
30A:A:K46 A:A:L38 94.75762.82YesNo098
31A:A:K46 A:A:S44 94.85563.06YesNo2499
32A:A:G40 A:A:S44 97.2241.86NoNo099
33A:A:F223 A:A:G40 97.27444.52YesNo099
34A:A:F223 A:A:L249 1004.87YesNo099
35A:A:L249 A:A:R208 99.64784.86NoYes099
36A:A:I212 A:A:R208 49.58295.01YesYes189
37A:A:I212 A:A:N256 52.5364.25YesNo188
38A:A:N256 A:A:W258 52.59083.39NoYes185
39A:A:W258 B:B:W332 51.96053.75YesYes159
40B:B:R314 B:B:W332 36.95720.99NoYes189
41B:B:R314 B:B:T274 15.84993.88NoNo188
42B:B:S275 B:B:T274 22.27844.8NoNo088
43B:B:L318 B:B:S275 21.96047.51YesNo068
44B:B:L318 B:B:T329 17.98914.42YesNo068
45R:R:I164 W:W:V45 11.84873.07YesYes070
46R:R:L87 R:R:S134 11.85566.01YesNo098
47R:R:N86 R:R:S134 11.41147.45YesNo098
48R:R:F83 R:R:I138 16.47073.77YesYes088
49R:R:F83 R:R:I164 14.30795.02YesYes087
50A:A:F223 A:A:L266 14.08853.65YesYes099
51B:B:L336 B:B:M61 19.10632.83YesNo076
52B:B:C317 B:B:M61 33.20484.86NoNo076
53B:B:C317 B:B:S316 33.83963.44NoNo079
54B:B:S316 B:B:W332 34.17976.18NoYes099
55B:B:S84 B:B:W63 10.6446.18YesYes057
56B:B:M61 B:B:W63 13.90934.65NoYes067
57B:B:S122 B:B:Y124 10.69695.09NoYes486
58B:B:I120 B:B:S122 10.95583.1NoNo468
59B:B:D118 B:B:I120 12.46858.4NoNo096
60B:B:D118 B:B:S97 12.900810.31NoNo098
61B:B:S97 B:B:W99 13.38613.71NoYes089
62A:A:F215 A:A:W211 18.594.01YesYes199
63A:A:R208 A:A:W211 50.02374YesYes199
64A:A:L38 A:A:M198 10.46425.65NoYes087
65A:A:W211 B:B:Y145 52.10812.89YesYes198
66A:A:K210 B:B:Y145 25.68813.58YesYes198
67A:A:K210 B:B:D228 20.18736.91YesYes199
68A:A:F223 A:A:V225 21.99072.62YesYes097
69A:A:F274 A:A:Y230 10.68876.19YesYes098
70A:A:F274 A:A:L227 17.76737.31YesNo097
71A:A:L227 A:A:L268 18.27595.54NoYes078
72B:B:I18 G:G:A23 10.03033.25YesNo078
73B:B:H183 B:B:V187 10.55936.92YesYes599
74B:B:S160 B:B:V187 12.86466.46YesYes569
75B:B:S147 B:B:S160 22.81884.89NoYes096
76B:B:S147 B:B:Y145 23.15942.54NoYes098
77B:B:H225 B:B:T243 12.177510.95YesYes198
78B:B:D247 B:B:H225 15.69536.3YesYes199
79B:B:D247 B:B:S227 20.55132.94YesNo196
80B:B:D228 B:B:S227 16.93557.36YesNo196
81B:B:W297 B:B:Y264 19.161612.54YesYes185
82B:B:W297 B:B:Y289 19.06856.75YesYes187
83B:B:C271 B:B:Y289 22.85374.03NoYes157
84B:B:C271 B:B:D290 24.35514.67NoYes156
85B:B:D290 B:B:R314 20.980821.44YesNo168
86B:B:I43 B:B:M45 10.01864.37YesYes134
87B:B:M45 B:B:W339 10.99883.49YesYes149
88B:B:T329 B:B:W339 14.46997.28NoYes089
89B:B:H142 B:B:S161 26.860216.74YesNo199
90B:B:G162 B:B:S161 28.07463.71NoNo199
91B:B:G162 B:B:Y145 24.66774.35NoYes198
92B:B:H142 B:B:W169 13.5543.17YesYes198
93B:B:D246 B:B:G272 15.3663.35YesNo094
94R:R:I138 R:R:R142 17.59097.52YesYes889
95B:B:D290 B:B:G272 15.02363.35YesNo064
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P79 R:R:S155 5.34 22 No No 7 7 2 2
R:R:N157 R:R:P79 3.26 22 No No 1 7 1 2
R:R:F83 R:R:I164 5.02 0 Yes Yes 8 7 2 1
R:R:I164 R:R:N86 5.66 0 Yes Yes 7 9 1 2
R:R:F118 R:R:I179 6.28 3 Yes No 6 5 2 1
R:R:F118 R:R:N183 9.67 3 Yes No 6 5 2 2
R:R:L172 R:R:V126 4.47 0 No No 4 5 1 2
R:R:N157 R:R:S155 5.96 22 No No 1 7 1 2
R:R:N157 W:W:V41 4.43 22 No No 1 0 1 0
R:R:I164 R:R:L160 5.71 0 Yes No 7 7 1 2
R:R:F161 R:R:S165 9.25 23 Yes No 2 4 1 1
R:R:F161 W:W:A44 2.77 23 Yes No 2 0 1 0
R:R:F161 W:W:V45 5.24 23 Yes Yes 2 0 1 0
R:R:F161 W:W:V48 2.62 23 Yes No 2 0 1 0
R:R:I164 W:W:V45 3.07 0 Yes Yes 7 0 1 0
R:R:S165 W:W:V45 3.23 23 No Yes 4 0 1 0
R:R:V169 W:W:T52 7.93 0 No No 4 0 1 0
R:R:L177 R:R:M180 2.83 0 No No 5 4 2 1
R:R:I179 W:W:A60 3.25 0 No No 5 0 1 0
R:R:M180 W:W:I56 5.83 0 No No 4 0 1 0
R:R:M180 W:W:I59 10.2 0 No No 4 0 1 0
R:R:G181 R:R:N183 5.09 0 No No 5 5 1 2
R:R:G181 W:W:V63 1.84 0 No No 5 0 1 0
R:R:V169 W:W:V48 1.6 0 No No 4 0 1 0
R:R:I173 R:R:V169 1.54 0 No No 4 4 2 1
R:R:L172 W:W:V49 1.49 0 No No 4 0 1 0
R:R:L172 W:W:I53 1.43 0 No No 4 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
25.00Single6KQIORG275696KQI-CB1-PubMed 104895-ORG27569
25.00Consensuscb1_off_alloOther Ligand6KQI-CB1-PubMed 104895-ORG27569
21.43Single5NDZAZ3451; Na5NDZ-PAR2-AZ3451; Na
14.29Single8U4OCholesterol8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
14.29Single8U4RCholesterol8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.33Single8U4QCholesterol8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
11.76Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7WU4K6G7WU4-ADGRF1-K6G-Gi1/&β;1/&γ;2
7.69Single8U4NCholesterol8U4N-CXCR4-Cholesterol-Gi1/&β;1/&γ;2
7.14Single6TQ9SB-4081246TQ9-OX1-SB-408124
7.14Single8U4PCholesterol8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
6.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
6.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
6.67Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.25Single6HLLCP999946HLL-NK1-CP99994
6.25Single6TP4ACT-4622066TP4-OX1-ACT-462206
6.25Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
6.25Single7FEEZCZ0117FEE-CB1-PubMed 104895-ZCZ011
6.25Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
6.25Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
5.88Single4S0VSuvorexant4S0V-OX2-Suvorexant
5.88Single5WS3EMPA5WS3-OX2-EMPA
5.88Single6ME2Ramelteon6ME2-MT1-Ramelteon
5.88Single6TODEMPA6TOD-OX1-EMPA-Na
5.88Single6TPJSuvorexant6TPJ-OX2-Suvorexant
5.88Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.88Single7F8ULintitript7F8U-CCKA-Lintitript
5.88Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.88Single7XRRLemborexant7XRR-OX2-Lemborexant
5.88Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
5.88Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8IWESpermidine8IWE-TAAR9-Spermidine
5.88Consensusorexin_offOrthosteric Ligandox2_off ox1_off
5.56Single4ZJCSB-6740424ZJC-OX1-SB-674042
5.56Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
5.56Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
5.56Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
5.56Single6TP3Nemorexant6TP3-OX1-Nemorexant
5.56Single6TPKRetosiban6TPK-OT-Retosiban
5.56Single6TPNHTL66416TPN-OX2-HTL6641
5.56Single6V9SGTPL114036V9S-OX1-GTPL11403
5.56Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single7WU3K6G7WU3-ADGRF1-K6G-Gs/&β;1/&γ;2
5.56Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
5.56Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
5.56Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
5.56Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
5.56Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
5.56Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
5.56Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
5.56Consensusvasopressin-ot_offOrthosteric Ligandot_off
5.26Single4YAYZD-71554YAY-AT1-ZD-7155
5.26Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
5.26Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
5.26Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
5.26Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
5.26Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
5.26Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
5.26Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
5.26Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.26Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.26Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.26Consensusadgrf1_on_alloOther Ligand7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2 8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
5.26Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
5.26Consensusblt_onOrthosteric Ligandblt1_on
5.26Consensuscck_offOrthosteric Ligandccka_off
5.26Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
5.26Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
5.26Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
5.26Consensusleuko_onOrthosteric Ligandblt_on
5.26Consensustachykinin_offOrthosteric Ligandnk1_off
5.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
5.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
5.00Single5WQCEMPA5WQC-OX2-EMPA
5.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
5.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
5.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
5.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
5.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
5.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
5.00Single6TP6Filorexant6TP6-OX1-Filorexant
5.00Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
4.76Single5TZR-5TZR-FFA1 (GPR40)-MK8666
4.76Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.76Single6E59L-7607356E59-NK1-L-760735
4.76Single6J20Aprepitant6J20-NK1-Aprepitant
4.76Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
4.76Single6TQ7SB-3348676TQ7-OX1-SB-334867
4.76Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76Single7W41PD1762527W41-BB2-PD176252
4.76Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
4.76Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
4.76Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
4.76Consensusbombesin_offOrthosteric Ligandbb2_off
4.76Consensuscck_onOrthosteric Ligandccka_on cckb_on
4.76Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
4.76Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
4.76Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
4.76Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
4.76Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
4.76Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
4.55Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.55Single6HLPNetupitant6HLP-NK1-Netupitant
4.55Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
4.55Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
4.55Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single7SHEPI; PE7SHE-GPR158-PI; PE
4.55Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
4.55Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
4.55Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
4.35Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.35Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
4.35Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
4.35Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
4.35Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
4.35Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.35Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.35Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.35Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
4.35Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
4.35Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
4.35Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
4.35Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
4.35Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.17Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
4.17Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
4.17Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
4.17Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
4.17Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.17Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
4.17Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
4.17Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
4.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
4.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
4.00Single7F8XNN90567F8X-CCKA-NN9056
4.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
4.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
4.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single6HLOAprepitant6HLO-NK1-Aprepitant
3.85Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
3.85Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
3.85Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
3.85Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.85Single7SK5CXCL127SK5-ACKR3-CXCL12
3.85Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
3.85Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
3.85Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
3.85Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
3.85Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
3.70Single3OE0CVX153OE0-CXCR4-CVX15
3.70Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
3.70Single6W25SHU91196W25-MC4-SHU9119-Ca
3.70Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
3.70Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
3.70Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
3.70Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
3.70Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
3.57Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
3.57Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
3.57Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
3.45Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
3.45Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
3.45Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
3.45Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
3.45Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
3.45Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
3.45Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
3.33Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
3.33Single7SK3CXCL127SK3-ACKR3-CXCL12
3.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
3.33Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.33Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
3.33Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
3.23Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
3.23Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
3.23Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.23Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
3.12Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.12Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
3.12Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
3.03Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.03Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.94Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
2.94Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
2.78Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
2.78Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
2.78Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.78Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
2.78Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
2.38Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1

PDB Summary
PDB 8G94
Class A
SubFamily Lipid
Type Lysophospholipid (S1P)
SubType S1P1
Species Homo Sapiens
Ligand -
Other Ligand(s) CD69
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.15
Date 2023-04-19 
D.O.I. 10.7554/eLife.88204
Net Summary
Imin 2.54
Number of Linked Nodes 901
Number of Links 1179
Number of Hubs 226
Number of Links mediated by Hubs 779
Number of Communities 28
Number of Nodes involved in Communities 318
Number of Links involved in Communities 491
Path Summary
Number Of Nodes in MetaPath 96
Number Of Links MetaPath 95
Number of Shortest Paths 1146613
Length Of Smallest Path 3
Average Path Length 23.9968
Length of Longest Path 58
Minimum Path Strength 1.275
Average Path Strength 5.61301
Maximum Path Strength 22.68
Minimum Path Correlation 0.7
Average Path Correlation 0.98094
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 53.8106
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 55.012
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP21453
Sequence
>8G94_Chain_R
VNYDIIVRH YNYTGKLNI KLTSVVFIL ICCFIILEN IFVLLTIWK 
TKKFHRPMY YFIGNLALS DLLAGVAYT ANLLLSGAT TYKLTPAQW 
FLREGSMFV ALSASVFSL LAIAIERYI TMLKMKLHN GSNNFRLFL 
LISACWVIS LILGGLPIM GWNCISALS SCSTVLPLY HKHYILFCT 
TVFTLLLLS IVILYCRIY SLVRTRSRR LTFRKKSLA LLKTVIIVL 
SVFIACWAP LFILLLLDV GCKVKTCDI LFRAEYFLV LAVLNSGTN 
PIIYTLTNK EMRRAFIRI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8G94_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMKITG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLVLAMN RMHESMKLF DSICNNKWF TDTSIILFL 
NKKDLFEEK IKKSPLTIC YPEYAGSNT YEEAAAYIQ CQFEDLNKR 
KDTKEIYTH FTCSTDTKN VQFVFDAVT DVIIKNNLK DCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8G94_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8G94_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3V2WALipidLysophospholipid (S1P)S1P1Homo sapiensPubChem 51892645--3.352012-02-1510.1126/science.1215904
3V2YALipidLysophospholipid (S1P)S1P1Homo sapiensPubChem 51892645--2.82012-02-1510.1126/science.1215904
7EO2ALipidLysophospholipid (S1P)S1P1Homo sapiensFTY720-P-Gi1/&β;1/&γ;22.892022-01-0510.1038/s41589-021-00930-3
7EO4ALipidLysophospholipid (S1P)S1P1Homo sapiensBAF312-Gi1/&β;1/&γ;22.862022-01-0510.1038/s41589-021-00930-3
7EVYALipidLysophospholipid (S1P)S1P1Homo sapiensSiponimod-Gi1/&β;1/&γ;22.982021-09-2910.1038/s41422-021-00566-x
7EVZALipidLysophospholipid (S1P)S1P1Homo sapiensCenerimod-Gi1/&β;1/&γ;23.072021-09-2910.1038/s41422-021-00566-x
7EW0ALipidLysophospholipid (S1P)S1P1Homo sapiensOzanimod-Gi1/&β;1/&γ;23.422021-09-2910.1038/s41422-021-00566-x
7EW7ALipidLysophospholipid (S1P)S1P1Homo sapiensPubChem 4077460-Gi1/&β;1/&γ;23.272021-09-2910.1038/s41422-021-00566-x
7TD3ALipidLysophospholipid (S1P)S1P1Homo sapiensS1P-Gi1/&β;1/&γ;232022-02-0910.1038/s41467-022-28417-2
7TD4ALipidLysophospholipid (S1P)S1P1Homo sapiensSiponimod-Gi1/&β;1/&γ;22.62022-02-0910.1038/s41467-022-28417-2
7VIEALipidLysophospholipid (S1P)S1P1Homo sapiensS1P-Gi1/&β;1/&γ;22.862022-09-2810.1073/pnas.2117716119
7VIFALipidLysophospholipid (S1P)S1P1Homo sapiens(S)-FTY720-P-Gi1/&β;1/&γ;22.832022-09-2810.1073/pnas.2117716119
7VIGALipidLysophospholipid (S1P)S1P1Homo sapiensCBP-307-Gi1/&β;1/&γ;22.892022-09-2810.1073/pnas.2117716119
7VIHALipidLysophospholipid (S1P)S1P1Homo sapiensCBP-307-Gi1/&β;1/&γ;22.982022-09-2810.1073/pnas.2117716119
7WF7ALipidLysophospholipid (S1P)S1P1Homo sapiensS1P-Gi1/&β;1/&γ;23.42022-01-0510.1038/s41589-021-00930-3




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