psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K34	3.12	Yes	No	0	0	6
2	L:L:?1	R:R:E121	6.84	Yes	Yes	1	0	5
3	L:L:?1	R:R:M124	5.21	Yes	No	0	0	6
4	L:L:?1	R:R:F125	27.83	Yes	No	1	0	5
5	L:L:?1	R:R:L128	8.16	Yes	No	1	0	6
6	L:L:?1	R:R:S129	7.75	Yes	No	0	0	6
7	L:L:?1	R:R:V132	5.49	Yes	No	0	0	7
8	L:L:?1	R:R:V194	4.39	Yes	Yes	1	0	4
9	L:L:?1	R:R:L195	4.08	Yes	Yes	1	0	3
10	L:L:?1	R:R:F210	3.59	Yes	Yes	1	0	7
11	L:L:?1	R:R:W269	7.55	Yes	Yes	1	0	8
12	L:L:?1	R:R:L272	12.24	Yes	No	0	0	6
13	L:L:?1	R:R:L276	6.12	Yes	No	0	0	6
14	L:L:?1	R:R:L297	5.1	Yes	No	1	0	5
15	R:R:T113	R:R:Y22	3.75	No	No	0	7	5
16	R:R:H28	R:R:I24	3.98	Yes	No	0	8	4
17	R:R:I25	R:R:P114	8.47	No	No	0	4	3
18	R:R:H28	R:R:R27	4.51	Yes	No	0	8	3
19	R:R:C184	R:R:H28	4.42	No	Yes	1	5	8
20	R:R:C191	R:R:H28	2.95	No	Yes	1	9	8
21	R:R:H28	R:R:L197	6.43	Yes	Yes	1	8	4
22	R:R:K34	R:R:Y29	5.97	No	Yes	0	6	7
23	R:R:W117	R:R:Y29	4.82	Yes	Yes	1	9	7
24	R:R:P196	R:R:Y29	6.95	No	Yes	1	3	7
25	R:R:S189	R:R:Y31	5.09	No	No	0	4	5
26	R:R:K285	R:R:Y31	4.78	No	No	0	2	5
27	R:R:T193	R:R:T32	3.14	No	No	0	5	8
28	R:R:I53	R:R:S49	3.1	No	No	0	3	5
29	R:R:L102	R:R:S49	4.5	No	No	0	5	5
30	R:R:F52	R:R:V51	3.93	Yes	No	0	6	5
31	R:R:F52	R:R:L102	3.65	Yes	No	0	6	5
32	R:R:F52	R:R:Y295	4.13	Yes	No	0	6	3
33	R:R:F52	R:R:V298	14.42	Yes	No	0	6	5
34	R:R:C56	R:R:Y98	5.38	No	Yes	0	5	6
35	R:R:D91	R:R:I59	4.2	Yes	No	2	9	7
36	R:R:G305	R:R:I59	7.05	No	No	2	7	7
37	R:R:I60	R:R:L92	4.28	No	No	0	6	6
38	R:R:E62	R:R:I309	8.2	No	No	0	8	6
39	R:R:A88	R:R:N63	4.69	No	No	0	9	9
40	R:R:D91	R:R:N63	9.42	Yes	No	0	9	9
41	R:R:L92	R:R:N63	6.87	No	No	0	6	9
42	R:R:F322	R:R:F65	5.36	No	No	0	7	7
43	R:R:T312	R:R:V66	3.17	No	No	0	7	9
44	R:R:A88	R:R:L67	4.73	No	No	0	9	8
45	R:R:I325	R:R:T69	4.56	No	No	0	6	8
46	R:R:I70	R:R:Y81	3.63	No	Yes	0	7	9
47	R:R:I325	R:R:K72	8.72	No	No	0	6	6
48	R:R:F76	R:R:T73	7.78	Yes	No	0	8	6
49	R:R:F76	R:R:Y81	18.57	Yes	Yes	0	8	9
50	R:R:H77	R:R:Y82	6.53	No	No	0	7	4
51	R:R:R78	R:R:Y81	11.32	No	Yes	0	7	9
52	R:R:E141	R:R:M80	6.77	No	No	0	9	8
53	R:R:M80	R:R:R142	4.96	No	Yes	0	8	9
54	R:R:N315	R:R:Y81	5.81	No	Yes	3	8	9
55	R:R:M318	R:R:Y81	4.79	No	Yes	3	8	9
56	R:R:L160	R:R:Y82	4.69	Yes	No	0	7	4
57	R:R:F83	R:R:I138	3.77	Yes	No	0	8	8
58	R:R:E141	R:R:F83	8.16	No	Yes	0	9	8
59	R:R:F83	R:R:L160	8.53	Yes	Yes	0	8	7
60	R:R:F83	R:R:L163	4.87	Yes	No	0	8	6
61	R:R:N86	R:R:S134	7.45	No	No	0	9	8
62	R:R:I164	R:R:N86	7.08	No	No	0	7	9
63	R:R:N86	R:R:W168	6.78	No	Yes	0	9	9
64	R:R:L87	R:R:S134	6.01	No	No	0	9	8
65	R:R:A130	R:R:S90	3.42	No	No	0	7	8
66	R:R:D91	R:R:S304	5.89	Yes	No	0	9	9
67	R:R:D91	R:R:G305	5.03	Yes	No	2	9	7
68	R:R:D91	R:R:P308	3.22	Yes	No	0	9	9
69	R:R:M124	R:R:Y98	5.99	No	Yes	0	6	6
70	R:R:L297	R:R:Y98	7.03	No	Yes	1	5	6
71	R:R:V298	R:R:Y98	5.05	No	Yes	0	5	6
72	R:R:V301	R:R:Y98	12.62	No	Yes	1	7	6
73	R:R:N101	R:R:R120	15.67	No	Yes	0	5	6
74	R:R:M124	R:R:N101	4.21	No	No	0	6	5
75	R:R:L104	R:R:R120	3.64	No	Yes	0	4	6
76	R:R:K111	R:R:T108	3	No	No	0	1	4
77	R:R:T109	R:R:Y110	4.99	No	No	0	5	5
78	R:R:R120	R:R:T109	3.88	Yes	No	0	6	5
79	R:R:L112	R:R:Q116	7.99	No	No	0	5	4
80	R:R:L112	R:R:W117	3.42	No	Yes	0	5	9
81	R:R:P114	R:R:T113	3.5	No	No	0	3	7
82	R:R:A115	R:R:T113	3.36	No	No	0	2	7
83	R:R:R120	R:R:W117	6	Yes	Yes	1	6	9
84	R:R:E121	R:R:W117	3.27	Yes	Yes	1	5	9
85	R:R:P196	R:R:W117	5.4	No	Yes	1	3	9
86	R:R:L197	R:R:W117	4.56	Yes	Yes	1	4	9
87	R:R:F118	R:R:I179	3.77	Yes	No	0	6	5
88	R:R:F118	R:R:N183	6.04	Yes	No	0	6	5
89	R:R:F118	R:R:L197	6.09	Yes	Yes	0	6	4
90	R:R:F118	R:R:Y198	5.16	Yes	Yes	0	6	4
91	R:R:E121	R:R:R120	3.49	Yes	Yes	1	5	6
92	R:R:E121	R:R:L195	3.98	Yes	Yes	1	5	3
93	R:R:E121	R:R:Y198	6.73	Yes	Yes	1	5	4
94	R:R:F125	R:R:Y202	10.32	No	Yes	1	5	7
95	R:R:C206	R:R:F125	4.19	No	No	1	6	5
96	R:R:S171	R:R:V126	3.23	No	No	0	8	5
97	R:R:L172	R:R:V126	4.47	No	No	0	4	5
98	R:R:L128	R:R:W269	3.42	No	Yes	1	6	8
99	R:R:L174	R:R:S129	6.01	No	No	0	5	6
100	R:R:A130	R:R:W168	6.48	No	Yes	5	7	9
101	R:R:A130	R:R:S171	3.42	No	No	5	7	8
102	R:R:L213	R:R:V132	2.98	No	No	0	8	7
103	R:R:F133	R:R:I170	5.02	No	No	0	5	4
104	R:R:F133	R:R:L213	10.96	No	No	0	5	8
105	R:R:F265	R:R:L135	6.09	No	No	0	9	9
106	R:R:L135	R:R:Y311	3.52	No	No	0	9	9
107	R:R:I140	R:R:L136	5.71	No	No	0	6	7
108	R:R:L136	R:R:S216	3	No	No	0	7	6
109	R:R:I217	R:R:L136	4.28	No	No	0	8	7
110	R:R:I138	R:R:R142	3.76	No	Yes	4	8	9
111	R:R:I138	R:R:Y311	9.67	No	No	4	8	9
112	R:R:A139	R:R:Y221	4	No	Yes	0	8	9
113	R:R:E141	R:R:T145	5.64	No	No	0	9	8
114	R:R:R142	R:R:Y221	5.14	Yes	Yes	0	9	9
115	R:R:R142	R:R:Y311	6.17	Yes	No	4	9	9
116	R:R:L147	R:R:Y143	3.52	No	No	0	6	8
117	R:R:L220	R:R:Y143	3.52	No	No	0	7	8
118	R:R:R223	R:R:Y143	12.35	No	No	0	5	8
119	R:R:I144	R:R:R159	3.76	No	Yes	0	4	5
120	R:R:I224	R:R:M146	5.83	No	No	0	9	8
121	R:R:M146	R:R:V228	3.04	No	No	0	8	8
122	R:R:K148	R:R:K150	18.68	No	No	0	6	7
123	R:R:M149	R:R:R231	7.44	No	No	0	8	7
124	R:R:K150	R:R:R159	3.71	No	Yes	0	7	5
125	R:R:N156	R:R:S155	4.47	No	No	6	7	7
126	R:R:R159	R:R:S155	5.27	Yes	No	6	5	7
127	R:R:N156	R:R:R159	3.62	No	Yes	6	7	5
128	R:R:F161	R:R:N157	3.62	No	No	0	2	1
129	R:R:F158	R:R:L162	3.65	No	No	0	4	3
130	R:R:I164	R:R:L160	4.28	No	Yes	0	7	7
131	R:R:C167	R:R:W168	3.92	No	Yes	0	6	9
132	R:R:S171	R:R:W168	4.94	No	Yes	5	8	9
133	R:R:C206	R:R:L174	3.17	No	No	0	6	5
134	R:R:L177	R:R:W182	3.42	No	No	0	5	5
135	R:R:P178	R:R:Y198	9.74	No	Yes	0	5	4
136	R:R:P178	R:R:Y202	15.3	No	Yes	0	5	7
137	R:R:G181	R:R:N183	3.39	No	No	0	5	5
138	R:R:H199	R:R:W182	4.23	No	No	0	4	5
139	R:R:W182	R:R:Y202	6.75	No	Yes	0	5	7
140	R:R:C184	R:R:C191	7.28	No	No	1	5	9
141	R:R:A187	R:R:S190	3.42	No	No	0	4	4
142	R:R:H199	R:R:S190	11.16	No	No	0	4	4
143	R:R:L195	R:R:S192	6.01	Yes	No	0	3	4
144	R:R:K200	R:R:S192	3.06	No	No	0	3	4
145	R:R:D279	R:R:S192	5.89	No	No	0	4	4
146	R:R:T193	R:R:V284	3.17	No	No	0	5	1
147	R:R:L290	R:R:T193	2.95	Yes	No	0	3	5
148	R:R:L195	R:R:V194	2.98	Yes	Yes	1	3	4
149	R:R:D279	R:R:V194	10.22	No	Yes	1	4	4
150	R:R:L290	R:R:V194	7.45	Yes	Yes	1	3	4
151	R:R:L195	R:R:Y198	8.21	Yes	Yes	1	3	4
152	R:R:L197	R:R:P196	3.28	Yes	No	1	4	3
153	R:R:H199	R:R:H201	13.14	No	No	0	4	4
154	R:R:K200	R:R:V280	3.04	No	No	0	3	4
155	R:R:C206	R:R:Y202	6.72	No	Yes	1	6	7
156	R:R:I203	R:R:L276	7.14	No	No	0	6	6
157	R:R:I203	R:R:V280	3.07	No	No	0	6	4
158	R:R:L204	R:R:V280	4.47	No	No	0	5	4
159	R:R:F205	R:R:V209	5.24	No	No	0	5	5
160	R:R:F273	R:R:T207	3.89	No	No	0	6	5
161	R:R:L213	R:R:V209	2.98	No	No	0	8	5
162	R:R:F210	R:R:L214	3.65	Yes	No	0	7	5
163	R:R:F210	R:R:W269	11.02	Yes	Yes	1	7	8
164	R:R:F210	R:R:F273	6.43	Yes	No	0	7	6
165	R:R:F273	R:R:T211	3.89	No	No	0	6	4
166	R:R:F265	R:R:L214	4.87	No	No	0	9	5
167	R:R:I266	R:R:L214	5.71	No	No	0	6	5
168	R:R:L262	R:R:V218	2.98	No	No	0	7	4
169	R:R:V261	R:R:Y221	5.05	No	Yes	0	8	9
170	R:R:L262	R:R:Y221	4.69	No	Yes	0	7	9
171	R:R:R223	R:R:S226	3.95	No	No	0	5	3
172	R:R:L227	R:R:R223	8.5	No	No	0	6	5
173	R:R:R229	R:R:Y225	11.32	No	No	0	5	6
174	R:R:L254	R:R:Y225	4.69	No	No	0	8	6
175	R:R:L255	R:R:Y225	12.89	No	No	0	8	6
176	R:R:L227	R:R:R231	17.01	No	No	0	6	7
177	R:R:L254	R:R:V228	4.47	No	No	0	8	8
178	R:R:R229	R:R:S251	3.95	No	No	0	5	7
179	R:R:L235	R:R:T236	2.95	No	No	0	6	4
180	R:R:K239	R:R:T236	9.01	No	No	0	2	4
181	R:R:F237	R:R:R238	11.76	No	No	0	3	5
182	R:R:T257	R:R:T314	4.71	No	No	0	9	7
183	R:R:L262	R:R:V258	2.98	No	No	0	7	8
184	R:R:I310	R:R:V264	4.61	No	No	0	8	7
185	R:R:F265	R:R:W269	5.01	No	Yes	0	9	8
186	R:R:C268	R:R:N303	7.87	No	No	0	8	9
187	R:R:A300	R:R:W269	5.19	No	Yes	0	7	8
188	R:R:N303	R:R:W269	10.17	No	Yes	0	9	8
189	R:R:L299	R:R:P271	3.28	No	No	0	7	9
190	R:R:F296	R:R:L275	18.27	No	No	0	4	4
191	R:R:C282	R:R:L278	4.76	No	No	0	4	4
192	R:R:D279	R:R:L290	8.14	No	Yes	1	4	3
193	R:R:C282	R:R:C287	7.28	No	No	0	4	3
194	R:R:C287	R:R:L290	4.76	No	Yes	0	3	3
195	R:R:L297	R:R:V301	2.98	No	No	1	5	7
196	R:R:S304	R:R:V301	3.23	No	No	0	9	7
197	R:R:N303	R:R:N307	5.45	No	No	0	9	9
198	R:R:I309	R:R:T306	3.04	No	No	0	6	5
199	R:R:M318	R:R:T312	12.04	No	No	0	8	7
200	R:R:M318	R:R:N315	9.82	No	No	3	8	8
201	R:R:K316	R:R:R319	9.9	No	No	0	6	8
202	R:R:F322	R:R:I323	3.77	No	No	0	7	3
203	R:R:I185	R:R:I24	2.94	No	No	0	3	4
204	R:R:I70	R:R:I84	2.94	No	No	0	7	8
205	R:R:I84	R:R:M80	2.92	No	No	0	8	8
206	R:R:I179	R:R:M180	2.92	No	No	0	5	4
207	R:R:F296	R:R:P271	2.89	No	No	0	4	9
208	R:R:I64	R:R:L92	2.85	No	No	0	4	6
209	R:R:I140	R:R:L220	2.85	No	No	0	6	7
210	R:R:I289	R:R:L275	2.85	No	No	0	3	4
211	R:R:I309	R:R:L313	2.85	No	No	0	6	6
212	R:R:A321	R:R:F76	2.77	No	Yes	0	7	8
213	R:R:A137	R:R:F83	2.77	No	Yes	0	7	8
214	R:R:L275	R:R:L290	2.77	No	Yes	0	4	3
215	R:R:L35	R:R:N30	2.75	No	No	0	6	9
216	R:R:R229	R:R:S226	2.64	No	No	0	5	3
217	R:R:F65	R:R:T69	2.59	No	No	0	7	8
218	R:R:R234	R:R:T230	2.59	No	No	0	4	5
219	R:R:H152	R:R:L151	2.57	No	No	0	7	4
220	R:R:F76	R:R:K75	2.48	Yes	No	0	8	6
221	R:R:L163	R:R:R159	2.43	No	Yes	0	6	5
222	R:R:L235	R:R:R234	2.43	No	No	0	6	4
223	R:R:I25	R:R:Y29	2.42	No	Yes	0	4	7
224	R:R:I217	R:R:Y221	2.42	No	Yes	0	8	9
225	R:R:D288	R:R:R292	2.38	No	No	0	3	4
226	R:R:E317	R:R:F76	2.33	No	Yes	0	7	8
227	R:R:L93	R:R:W168	2.28	No	Yes	0	6	9
228	R:R:G122	R:R:G175	2.11	No	No	0	6	6
229	R:R:G175	R:R:G176	2.11	No	No	0	6	4
230	R:R:G176	R:R:P178	2.03	No	No	0	4	5
231	R:R:A88	R:R:G85	1.95	No	No	0	9	5
232	R:R:A94	R:R:G95	1.95	No	No	0	8	7
233	R:R:A270	R:R:P271	1.87	No	No	0	6	9
234	R:R:G33	R:R:T32	1.82	No	No	0	7	8
235	R:R:A127	R:R:A94	1.79	No	No	0	6	8
236	R:R:A127	R:R:A97	1.79	No	No	0	6	4
237	R:R:P79	R:R:S155	1.78	No	No	0	7	7
238	R:R:A97	R:R:S123	1.71	No	No	0	4	4
239	R:R:C222	R:R:V218	1.71	No	No	0	3	4
240	R:R:G154	R:R:N153	1.7	No	No	0	4	4
241	R:R:A293	R:R:V194	1.7	No	Yes	0	4	4
242	R:R:C56	R:R:T99	1.69	No	No	0	5	6
243	R:R:C57	R:R:I53	1.64	No	No	0	5	3
244	R:R:S131	R:R:S90	1.63	No	No	0	9	8
245	R:R:S131	R:R:S304	1.63	No	No	0	9	9
246	R:R:S232	R:R:T236	1.6	No	No	0	5	4
247	R:R:T48	R:R:V51	1.59	No	No	0	5	5
248	R:R:T208	R:R:V209	1.59	No	No	0	4	5
249	R:R:T257	R:R:V261	1.59	No	No	0	9	8
250	R:R:T306	R:R:V264	1.59	No	No	0	5	7
251	R:R:I55	R:R:V298	1.54	No	No	0	6	5
252	R:R:I60	R:R:V96	1.54	No	No	0	6	5
253	R:R:A94	R:R:D91	1.54	No	Yes	0	8	9
254	R:R:I170	R:R:V169	1.54	No	No	0	4	4
255	R:R:I260	R:R:V264	1.54	No	No	0	6	7
256	R:R:I310	R:R:V261	1.54	No	No	0	8	8
257	R:R:I325	R:R:T73	1.52	No	No	0	6	6
258	R:R:K285	R:R:V284	1.52	No	No	0	2	1
259	R:R:A253	R:R:E249	1.51	No	No	0	7	5
260	R:R:L188	R:R:S189	1.5	No	No	0	2	4
261	R:R:K283	R:R:T286	1.5	No	No	0	1	1
262	R:R:N101	R:R:S105	1.49	No	No	0	5	4
263	R:R:L68	R:R:T69	1.47	No	No	0	4	8
264	R:R:L277	R:R:T207	1.47	No	No	0	6	5
265	R:R:D23	R:R:V26	1.46	No	No	0	7	6
266	R:R:I241	R:R:K239	1.45	No	No	0	2	2
267	R:R:E249	R:R:S248	1.44	No	No	0	5	4
268	R:R:I53	R:R:L103	1.43	No	No	0	3	6
269	R:R:L67	R:R:L89	1.38	No	No	0	8	5
270	R:R:L89	R:R:L93	1.38	No	No	0	5	6
271	R:R:L160	R:R:N157	1.37	Yes	No	0	7	1
272	R:R:L119	R:R:Q116	1.33	No	No	0	4	4
273	R:R:F158	R:R:N156	1.21	No	No	0	4	7
274	R:R:L313	R:R:R319	1.21	No	No	0	6	8
275	R:R:D23	R:R:R27	1.19	No	No	0	7	3
276	R:R:D288	R:R:F291	1.19	No	No	0	3	1
277	R:R:E317	R:R:R320	1.16	No	No	0	7	5
278	R:R:E294	R:R:Y295	1.12	No	No	0	3	3
279	R:R:R231	R:R:R234	1.07	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.67643	14	1	0
2	R:R:H28	4.458	5	1	8
3	R:R:Y29	5.04	4	1	7
4	R:R:F52	6.5325	4	0	6
5	R:R:F76	6.786	5	0	8
6	R:R:Y81	8.824	5	3	9
7	R:R:F83	5.62	5	0	8
8	R:R:D91	4.88333	6	2	9
9	R:R:Y98	7.214	5	1	6
10	R:R:W117	4.57833	6	1	9
11	R:R:F118	5.265	4	0	6
12	R:R:R120	6.536	5	1	6
13	R:R:E121	4.862	5	1	5
14	R:R:R142	5.0075	4	4	9
15	R:R:R159	3.758	5	6	5
16	R:R:L160	4.7175	4	0	7
17	R:R:W168	4.88	5	5	9
18	R:R:V194	5.348	5	1	4
19	R:R:L195	5.052	5	1	3
20	R:R:L197	5.09	4	1	4
21	R:R:Y198	7.46	4	1	4
22	R:R:Y202	9.7725	4	1	7
23	R:R:F210	6.1725	4	1	7
24	R:R:Y221	4.26	5	0	9
25	R:R:W269	7.06	6	1	8
26	R:R:L290	5.214	5	1	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K34	11.5342	3.12	Yes	No	0	0	6
2	R:R:K34	R:R:Y29	10.2779	5.97	No	Yes	0	6	7
3	L:L:?1	R:R:E121	37.3755	6.84	Yes	Yes	1	0	5
4	R:R:E121	R:R:W117	22.4305	3.27	Yes	Yes	1	5	9
5	R:R:L197	R:R:W117	16.364	4.56	Yes	Yes	1	4	9
6	R:R:H28	R:R:L197	16.9173	6.43	Yes	Yes	1	8	4
7	L:L:?1	R:R:V194	30.274	4.39	Yes	Yes	1	0	4
8	R:R:L290	R:R:V194	30.8859	7.45	Yes	Yes	1	3	4
9	R:R:L290	R:R:T193	14.5219	2.95	Yes	No	0	3	5
10	L:L:?1	R:R:M124	23.0098	5.21	Yes	No	0	0	6
11	R:R:M124	R:R:Y98	23.2637	5.99	No	Yes	0	6	6
12	R:R:V298	R:R:Y98	36.4707	5.05	No	Yes	0	5	6
13	R:R:F52	R:R:V298	30.5214	14.42	Yes	No	0	6	5
14	R:R:F52	R:R:L102	15.4202	3.65	Yes	No	0	6	5
15	R:R:L102	R:R:S49	12.3609	4.5	No	No	0	5	5
16	L:L:?1	R:R:L297	52.4963	5.1	Yes	No	1	0	5
17	R:R:L297	R:R:Y98	19.8334	7.03	No	Yes	1	5	6
18	R:R:L297	R:R:V301	31.6279	2.98	No	No	1	5	7
19	R:R:S304	R:R:V301	35.5985	3.23	No	No	0	9	7
20	R:R:D91	R:R:S304	24.8259	5.89	Yes	No	0	9	9
21	R:R:D91	R:R:N63	11.2934	9.42	Yes	No	0	9	9
22	L:L:?1	R:R:W269	94.3891	7.55	Yes	Yes	1	0	8
23	R:R:F265	R:R:W269	96.1075	5.01	No	Yes	0	9	8
24	R:R:F265	R:R:L135	100	6.09	No	No	0	9	9
25	R:R:L135	R:R:Y311	99.5248	3.52	No	No	0	9	9
26	R:R:R142	R:R:Y311	77.4588	6.17	Yes	No	4	9	9
27	R:R:R142	R:R:Y221	67.4998	5.14	Yes	Yes	0	9	9
28	R:R:V261	R:R:Y221	20.647	5.05	No	Yes	0	8	9
29	R:R:I310	R:R:V261	15.6936	1.54	No	No	0	8	8
30	R:R:I310	R:R:V264	14.0012	4.61	No	No	0	8	7
31	R:R:T306	R:R:V264	10.5774	1.59	No	No	0	5	7
32	R:R:M80	R:R:R142	33.5677	4.96	No	Yes	0	8	9
33	R:R:I84	R:R:M80	35.3577	2.92	No	No	0	8	8
34	R:R:I70	R:R:I84	33.7955	2.94	No	No	0	7	8
35	R:R:I70	R:R:Y81	32.3439	3.63	No	Yes	0	7	9
36	R:R:F76	R:R:Y81	22.6648	18.57	Yes	Yes	0	8	9
37	R:R:F76	R:R:T73	14.203	7.78	Yes	No	0	8	6
38	R:R:I325	R:R:T73	12.465	1.52	No	No	0	6	6
39	R:R:I138	R:R:Y311	21.6429	9.67	No	No	4	8	9
40	R:R:F83	R:R:I138	30.951	3.77	Yes	No	0	8	8
41	R:R:F83	R:R:L160	20.4778	8.53	Yes	Yes	0	8	7
42	R:R:F83	R:R:L163	17.093	4.87	Yes	No	0	8	6
43	R:R:S131	R:R:S304	13.8189	1.63	No	No	0	9	9
44	R:R:S131	R:R:S90	13.1485	1.63	No	No	0	9	8
45	R:R:A130	R:R:S90	12.7905	3.42	No	No	0	7	8
46	R:R:N86	R:R:W168	14.1834	6.78	No	Yes	0	9	9
47	R:R:I164	R:R:L160	14.2941	4.28	No	Yes	0	7	7
48	R:R:E121	R:R:Y198	13.194	6.73	Yes	Yes	1	5	4
49	R:R:F118	R:R:Y198	15.993	5.16	Yes	Yes	0	6	4
50	L:L:?1	R:R:L195	15.8953	4.08	Yes	Yes	1	0	3
51	R:R:L195	R:R:Y198	15.4137	8.21	Yes	Yes	1	3	4
52	L:L:?1	R:R:F125	18.3623	27.83	Yes	No	1	0	5
53	R:R:F125	R:R:Y202	15.2835	10.32	No	Yes	1	5	7
54	L:L:?1	R:R:V132	13.7929	5.49	Yes	No	0	0	7
55	R:R:L213	R:R:V132	12.1135	2.98	No	No	0	8	7
56	R:R:I217	R:R:Y221	43.5006	2.42	No	Yes	0	8	9
57	R:R:I217	R:R:L136	42.0426	4.28	No	No	0	8	7
58	R:R:I140	R:R:L136	39.0874	5.71	No	No	0	6	7
59	R:R:I140	R:R:L220	37.5903	2.85	No	No	0	6	7
60	R:R:L220	R:R:Y143	36.0802	3.52	No	No	0	7	8
61	R:R:R223	R:R:Y143	33.0209	12.35	No	No	0	5	8
62	R:R:L163	R:R:R159	15.4202	2.43	No	Yes	0	6	5
63	R:R:R223	R:R:S226	15.3486	3.95	No	No	0	5	3
64	R:R:R229	R:R:S226	13.6562	2.64	No	No	0	5	3
65	R:R:R229	R:R:Y225	10.3365	11.32	No	No	0	5	6
66	R:R:L227	R:R:R223	17.2362	8.5	No	No	0	6	5
67	R:R:L227	R:R:R231	15.5569	17.01	No	No	0	6	7
68	R:R:W182	R:R:Y202	10.4602	6.75	No	Yes	0	5	7
69	R:R:P178	R:R:Y198	12.7059	9.74	No	Yes	0	5	4
70	R:R:R231	R:R:R234	12.2958	1.07	No	No	0	7	4
71	R:R:L275	R:R:L290	10.9289	2.77	No	Yes	0	4	3
72	R:R:G176	R:R:P178	12.2567	2.03	No	No	0	4	5
73	R:R:I164	R:R:N86	13.2461	7.08	No	No	0	7	9
74	R:R:I138	R:R:R142	10.5839	3.76	No	Yes	4	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:K34	3.12	1	Yes	No	0	6	0	1
L:L:?1	R:R:E121	6.84	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M124	5.21	1	Yes	No	0	6	0	1
L:L:?1	R:R:F125	27.83	1	Yes	No	0	5	0	1
L:L:?1	R:R:L128	8.16	1	Yes	No	0	6	0	1
L:L:?1	R:R:S129	7.75	1	Yes	No	0	6	0	1
L:L:?1	R:R:V132	5.49	1	Yes	No	0	7	0	1
L:L:?1	R:R:V194	4.39	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L195	4.08	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:F210	3.59	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:W269	7.55	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L272	12.24	1	Yes	No	0	6	0	1
L:L:?1	R:R:L276	6.12	1	Yes	No	0	6	0	1
L:L:?1	R:R:L297	5.1	1	Yes	No	0	5	0	1
R:R:K34	R:R:Y29	5.97	0	No	Yes	6	7	1	2
R:R:W117	R:R:Y29	4.82	1	Yes	Yes	9	7	2	2
R:R:M124	R:R:Y98	5.99	0	No	Yes	6	6	1	2
R:R:L297	R:R:Y98	7.03	1	No	Yes	5	6	1	2
R:R:V301	R:R:Y98	12.62	1	No	Yes	7	6	2	2
R:R:N101	R:R:R120	15.67	0	No	Yes	5	6	2	2
R:R:M124	R:R:N101	4.21	0	No	No	6	5	1	2
R:R:R120	R:R:W117	6	1	Yes	Yes	6	9	2	2
R:R:E121	R:R:W117	3.27	1	Yes	Yes	5	9	1	2
R:R:E121	R:R:R120	3.49	1	Yes	Yes	5	6	1	2
R:R:E121	R:R:L195	3.98	1	Yes	Yes	5	3	1	1
R:R:E121	R:R:Y198	6.73	1	Yes	Yes	5	4	1	2
R:R:F125	R:R:Y202	10.32	1	No	Yes	5	7	1	2
R:R:C206	R:R:F125	4.19	1	No	No	6	5	2	1
R:R:L128	R:R:W269	3.42	1	No	Yes	6	8	1	1
R:R:L174	R:R:S129	6.01	0	No	No	5	6	2	1
R:R:L213	R:R:V132	2.98	0	No	No	8	7	2	1
R:R:C206	R:R:L174	3.17	1	No	No	6	5	2	2
R:R:L195	R:R:S192	6.01	1	Yes	No	3	4	1	2
R:R:D279	R:R:S192	5.89	1	No	No	4	4	2	2
R:R:L195	R:R:V194	2.98	1	Yes	Yes	3	4	1	1
R:R:D279	R:R:V194	10.22	1	No	Yes	4	4	2	1
R:R:L290	R:R:V194	7.45	1	Yes	Yes	3	4	2	1
R:R:L195	R:R:Y198	8.21	1	Yes	Yes	3	4	1	2
R:R:C206	R:R:Y202	6.72	1	No	Yes	6	7	2	2
R:R:I203	R:R:L276	7.14	0	No	No	6	6	2	1
R:R:F210	R:R:L214	3.65	1	Yes	No	7	5	1	2
R:R:F210	R:R:W269	11.02	1	Yes	Yes	7	8	1	1
R:R:F210	R:R:F273	6.43	1	Yes	No	7	6	1	2
R:R:F265	R:R:L214	4.87	0	No	No	9	5	2	2
R:R:F265	R:R:W269	5.01	0	No	Yes	9	8	2	1
R:R:A300	R:R:W269	5.19	0	No	Yes	7	8	2	1
R:R:N303	R:R:W269	10.17	0	No	Yes	9	8	2	1
R:R:D279	R:R:L290	8.14	1	No	Yes	4	3	2	2
R:R:L297	R:R:V301	2.98	1	No	No	5	7	1	2
R:R:A293	R:R:V194	1.7	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EVZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	259
Number of Links	279
Number of Hubs	26
Number of Links mediated by Hubs	111
Number of Communities	6
Number of Nodes involved in Communities	39
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	36451
Length Of Smallest Path	3
Average Path Length	12.1388
Length of Longest Path	28
Minimum Path Strength	1.325
Average Path Strength	5.52702
Maximum Path Strength	20.035
Minimum Path Correlation	0.7
Average Path Correlation	0.931836
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	59.3476
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.858
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JER
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	JER
Name	Cenerimod
Synonyms	Cenerimod
Identifier
Formula	C25 H31 N3 O5
Molecular Weight	453.531
SMILES
PubChem	49871973
Formal Charge	0
Total Atoms	64
Total Chiral Atoms	1
Total Bonds	67
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7EVZ_nogp_Chain_R Y D I I V R H Y N Y T G K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K M K L H N G S N N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F R K N I S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.