psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K34	3.17	Yes	No	0	0	6
2	L:L:?1	R:R:E121	10.91	Yes	Yes	1	0	5
3	L:L:?1	R:R:M124	5.29	Yes	No	0	0	6
4	L:L:?1	R:R:F125	25.52	Yes	No	1	0	5
5	L:L:?1	R:R:L128	7.25	Yes	No	0	0	6
6	L:L:?1	R:R:S129	3.37	Yes	No	0	0	6
7	L:L:?1	R:R:V194	3.34	Yes	Yes	1	0	4
8	L:L:?1	R:R:L195	6.21	Yes	Yes	1	0	3
9	L:L:?1	R:R:C206	4.75	Yes	No	1	0	6
10	L:L:?1	R:R:F210	8.2	Yes	No	1	0	7
11	L:L:?1	R:R:W269	4.26	Yes	Yes	1	0	8
12	L:L:?1	R:R:L272	5.18	Yes	Yes	1	0	6
13	L:L:?1	R:R:L276	5.18	Yes	Yes	1	0	6
14	L:L:?1	R:R:E294	2.97	Yes	No	0	0	3
15	L:L:?1	R:R:L297	8.29	Yes	Yes	1	0	5
16	R:R:P114	R:R:Y22	4.17	No	No	0	3	5
17	R:R:I24	R:R:P114	5.08	No	No	0	4	3
18	R:R:I25	R:R:Y29	4.84	No	Yes	0	4	7
19	R:R:L188	R:R:R27	4.86	Yes	No	0	2	3
20	R:R:H28	R:R:L188	2.57	No	Yes	0	8	2
21	R:R:H28	R:R:P196	6.1	No	No	0	8	3
22	R:R:H28	R:R:L197	5.14	No	No	0	8	4
23	R:R:K34	R:R:Y29	5.97	No	Yes	0	6	7
24	R:R:Y110	R:R:Y29	4.96	No	Yes	0	5	7
25	R:R:W117	R:R:Y29	5.79	Yes	Yes	0	9	7
26	R:R:P196	R:R:Y29	8.34	No	Yes	0	3	7
27	R:R:L188	R:R:Y31	10.55	Yes	No	2	2	5
28	R:R:S189	R:R:Y31	3.82	No	No	2	4	5
29	R:R:L102	R:R:S49	9.01	No	No	0	5	5
30	R:R:F52	R:R:V51	3.93	Yes	No	0	6	5
31	R:R:L54	R:R:V51	4.47	No	No	0	4	5
32	R:R:F52	R:R:Y98	4.13	Yes	Yes	0	6	6
33	R:R:F52	R:R:L102	3.65	Yes	No	0	6	5
34	R:R:F52	R:R:V298	10.49	Yes	No	0	6	5
35	R:R:I53	R:R:L102	2.85	No	No	0	3	5
36	R:R:I55	R:R:L54	2.85	No	No	0	6	4
37	R:R:C56	R:R:Y98	4.03	No	Yes	0	5	6
38	R:R:F58	R:R:L61	3.65	No	No	0	4	4
39	R:R:E62	R:R:F58	7	No	No	0	8	4
40	R:R:I59	R:R:N63	2.83	No	Yes	0	7	9
41	R:R:G305	R:R:I59	7.05	No	No	0	7	7
42	R:R:I60	R:R:L92	2.85	No	Yes	0	6	6
43	R:R:I60	R:R:V96	3.07	No	No	0	6	5
44	R:R:E62	R:R:I309	4.1	No	No	0	8	6
45	R:R:D91	R:R:N63	13.46	No	Yes	0	9	9
46	R:R:L92	R:R:N63	6.87	Yes	Yes	0	6	9
47	R:R:F65	R:R:T69	3.89	No	No	0	7	8
48	R:R:F322	R:R:F65	5.36	No	No	0	7	7
49	R:R:K72	R:R:L68	14.1	No	No	0	6	4
50	R:R:K72	R:R:W71	9.28	No	No	0	6	3
51	R:R:K75	R:R:T73	4.5	No	No	0	6	6
52	R:R:F76	R:R:T73	9.08	Yes	No	0	8	6
53	R:R:H77	R:R:K74	2.62	No	No	0	7	6
54	R:R:E317	R:R:K75	5.4	No	No	0	7	6
55	R:R:F76	R:R:Y81	18.57	Yes	No	0	8	9
56	R:R:E317	R:R:F76	5.83	No	Yes	0	7	8
57	R:R:A321	R:R:F76	2.77	No	Yes	0	7	8
58	R:R:H77	R:R:Y82	3.27	No	No	0	7	4
59	R:R:M80	R:R:R78	3.72	No	No	0	8	7
60	R:R:R78	R:R:Y81	14.4	No	No	0	7	9
61	R:R:I84	R:R:M80	2.92	No	No	0	8	8
62	R:R:E141	R:R:M80	8.12	No	No	0	9	8
63	R:R:N315	R:R:Y81	3.49	No	No	0	8	9
64	R:R:L160	R:R:Y82	5.86	Yes	No	0	7	4
65	R:R:A137	R:R:F83	2.77	No	Yes	0	7	8
66	R:R:F83	R:R:I138	3.77	Yes	Yes	0	8	8
67	R:R:E141	R:R:F83	10.49	No	Yes	0	9	8
68	R:R:F83	R:R:L160	7.31	Yes	Yes	0	8	7
69	R:R:F83	R:R:L163	3.65	Yes	No	0	8	6
70	R:R:I164	R:R:N86	5.66	No	No	0	7	9
71	R:R:N86	R:R:W168	7.91	No	No	0	9	9
72	R:R:L87	R:R:S134	9.01	No	No	0	9	8
73	R:R:L135	R:R:L87	2.77	No	No	0	9	9
74	R:R:I138	R:R:L87	2.85	Yes	No	0	8	9
75	R:R:D91	R:R:S304	5.89	No	No	0	9	9
76	R:R:D91	R:R:P308	3.22	No	No	0	9	9
77	R:R:T99	R:R:V96	3.17	No	No	0	6	5
78	R:R:L297	R:R:Y98	4.69	Yes	Yes	0	5	6
79	R:R:V301	R:R:Y98	11.36	No	Yes	0	7	6
80	R:R:N101	R:R:R120	8.44	No	Yes	0	5	6
81	R:R:M124	R:R:N101	5.61	No	No	0	6	5
82	R:R:G106	R:R:S105	3.71	No	No	0	4	4
83	R:R:T109	R:R:Y110	3.75	No	No	0	5	5
84	R:R:R120	R:R:T109	6.47	Yes	No	0	6	5
85	R:R:L112	R:R:Q116	7.99	No	No	0	5	4
86	R:R:P114	R:R:T113	5.25	No	No	0	3	7
87	R:R:R120	R:R:W117	7	Yes	Yes	0	6	9
88	R:R:E121	R:R:W117	11.99	Yes	Yes	1	5	9
89	R:R:L195	R:R:W117	5.69	Yes	Yes	1	3	9
90	R:R:L197	R:R:W117	10.25	No	Yes	0	4	9
91	R:R:F118	R:R:I179	5.02	Yes	No	0	6	5
92	R:R:F118	R:R:N183	8.46	Yes	No	0	6	5
93	R:R:F118	R:R:L197	9.74	Yes	No	0	6	4
94	R:R:F118	R:R:Y198	4.13	Yes	Yes	0	6	4
95	R:R:E121	R:R:L195	3.98	Yes	Yes	1	5	3
96	R:R:E121	R:R:Y198	7.86	Yes	Yes	1	5	4
97	R:R:F125	R:R:Y202	5.16	No	Yes	1	5	7
98	R:R:C206	R:R:F125	2.79	No	No	1	6	5
99	R:R:L172	R:R:V126	2.98	No	No	0	4	5
100	R:R:A130	R:R:W168	3.89	No	No	3	7	9
101	R:R:A130	R:R:S171	3.42	No	No	3	7	8
102	R:R:S131	R:R:S304	3.26	No	No	0	9	9
103	R:R:V132	R:R:W269	7.36	No	Yes	0	7	8
104	R:R:F133	R:R:L213	14.61	No	No	0	5	8
105	R:R:I217	R:R:L135	2.85	No	No	0	8	9
106	R:R:L135	R:R:N307	4.12	No	No	0	9	9
107	R:R:I140	R:R:L136	7.14	No	No	0	6	7
108	R:R:L136	R:R:S216	3	No	No	0	7	6
109	R:R:I217	R:R:L136	5.71	No	No	0	8	7
110	R:R:I138	R:R:R142	3.76	Yes	No	0	8	9
111	R:R:I138	R:R:Y311	6.04	Yes	No	0	8	9
112	R:R:A139	R:R:Y221	4	No	No	0	8	9
113	R:R:I140	R:R:L220	2.85	No	No	0	6	7
114	R:R:E141	R:R:T145	4.23	No	No	0	9	8
115	R:R:R142	R:R:Y221	7.2	No	No	0	9	9
116	R:R:L147	R:R:Y143	3.52	No	No	0	6	8
117	R:R:L220	R:R:Y143	4.69	No	No	0	7	8
118	R:R:R223	R:R:Y143	9.26	No	No	0	5	8
119	R:R:I144	R:R:R159	3.76	No	No	0	4	5
120	R:R:I224	R:R:M146	7.29	No	No	0	9	8
121	R:R:M146	R:R:V228	3.04	No	No	0	8	8
122	R:R:M149	R:R:R231	6.2	No	No	0	8	7
123	R:R:G154	R:R:N153	3.39	No	No	0	4	4
124	R:R:N156	R:R:S155	4.47	No	No	0	7	7
125	R:R:F158	R:R:L162	3.65	No	No	0	4	3
126	R:R:I164	R:R:L160	4.28	No	Yes	0	7	7
127	R:R:S171	R:R:W168	4.94	No	No	3	8	9
128	R:R:I170	R:R:L174	2.85	No	No	0	4	5
129	R:R:L177	R:R:P178	4.93	No	Yes	1	5	5
130	R:R:L177	R:R:W182	4.56	No	No	0	5	5
131	R:R:L177	R:R:Y202	3.52	No	Yes	1	5	7
132	R:R:P178	R:R:Y198	9.74	Yes	Yes	1	5	4
133	R:R:P178	R:R:Y202	11.13	Yes	Yes	1	5	7
134	R:R:I185	R:R:N183	7.08	No	No	0	3	5
135	R:R:C184	R:R:C191	7.28	No	No	0	5	9
136	R:R:C184	R:R:H199	4.42	No	Yes	0	5	4
137	R:R:A187	R:R:S190	3.42	No	No	0	4	4
138	R:R:L188	R:R:S189	3	Yes	No	2	2	4
139	R:R:H199	R:R:S190	8.37	Yes	No	0	4	4
140	R:R:L290	R:R:T193	2.95	Yes	No	0	3	5
141	R:R:L195	R:R:V194	4.47	Yes	Yes	1	3	4
142	R:R:D279	R:R:V194	2.92	Yes	Yes	0	4	4
143	R:R:L195	R:R:Y198	4.69	Yes	Yes	1	3	4
144	R:R:H199	R:R:H201	14.33	Yes	No	0	4	4
145	R:R:K200	R:R:V280	9.11	No	No	0	3	4
146	R:R:C206	R:R:Y202	4.03	No	Yes	1	6	7
147	R:R:I203	R:R:L276	5.71	No	Yes	0	6	6
148	R:R:F205	R:R:T208	2.59	No	No	0	5	4
149	R:R:F273	R:R:T207	2.59	No	No	0	6	5
150	R:R:L276	R:R:T207	2.95	Yes	No	0	6	5
151	R:R:F210	R:R:W269	13.03	No	Yes	1	7	8
152	R:R:F210	R:R:F273	5.36	No	No	0	7	6
153	R:R:F265	R:R:L214	3.65	No	No	0	9	5
154	R:R:I266	R:R:L214	5.71	No	No	0	6	5
155	R:R:L262	R:R:V218	8.94	No	No	0	7	4
156	R:R:R229	R:R:Y225	3.09	No	Yes	4	5	6
157	R:R:S251	R:R:Y225	3.82	No	Yes	4	7	6
158	R:R:L254	R:R:Y225	5.86	No	Yes	0	8	6
159	R:R:L227	R:R:R231	6.07	No	No	0	6	7
160	R:R:L254	R:R:V228	4.47	No	No	0	8	8
161	R:R:R229	R:R:S251	3.95	No	No	4	5	7
162	R:R:R234	R:R:T230	3.88	No	No	0	4	5
163	R:R:S232	R:R:T236	3.2	No	No	0	5	4
164	R:R:K239	R:R:T236	6.01	No	No	0	2	4
165	R:R:F237	R:R:R238	9.62	No	No	0	3	5
166	R:R:L254	R:R:V258	2.98	No	No	0	8	8
167	R:R:T257	R:R:T314	3.14	No	No	0	9	7
168	R:R:I260	R:R:I310	2.94	No	No	0	6	8
169	R:R:V261	R:R:Y311	3.79	No	No	0	8	9
170	R:R:I266	R:R:L262	4.28	No	No	0	6	7
171	R:R:I310	R:R:V264	4.61	No	No	0	8	7
172	R:R:F265	R:R:W269	11.02	No	Yes	0	9	8
173	R:R:L272	R:R:W269	3.42	Yes	Yes	1	6	8
174	R:R:N303	R:R:W269	9.04	No	Yes	0	9	8
175	R:R:L299	R:R:P271	6.57	No	No	0	7	9
176	R:R:L272	R:R:L276	2.77	Yes	Yes	1	6	6
177	R:R:L272	R:R:L297	2.77	Yes	Yes	1	6	5
178	R:R:F273	R:R:L277	7.31	No	No	0	6	6
179	R:R:I274	R:R:L277	2.85	No	No	0	5	6
180	R:R:L275	R:R:L290	2.77	No	Yes	0	4	3
181	R:R:F296	R:R:L275	12.18	No	No	0	4	4
182	R:R:D279	R:R:L276	2.71	Yes	Yes	0	4	6
183	R:R:D279	R:R:V280	2.92	Yes	No	0	4	4
184	R:R:D279	R:R:L290	4.07	Yes	Yes	0	4	3
185	R:R:G281	R:R:V280	3.68	No	No	0	4	4
186	R:R:C282	R:R:T286	5.07	No	No	0	4	1
187	R:R:C282	R:R:C287	7.28	No	No	5	4	3
188	R:R:K283	R:R:T286	4.5	No	No	0	1	1
189	R:R:C287	R:R:L290	4.76	No	Yes	0	3	3
190	R:R:N303	R:R:N307	8.17	No	No	0	9	9
191	R:R:I309	R:R:L313	2.85	No	No	0	6	6
192	R:R:M318	R:R:T312	6.02	No	No	0	8	7
193	R:R:M318	R:R:N315	11.22	No	No	0	8	8
194	R:R:K316	R:R:R319	3.71	No	No	0	6	8
195	R:R:F322	R:R:I323	3.77	No	No	0	7	3
196	R:R:F133	R:R:I170	2.51	No	No	0	5	4
197	R:R:T48	R:R:Y295	2.5	No	No	0	5	3
198	R:R:F205	R:R:L174	2.44	No	No	0	5	5
199	R:R:L104	R:R:R120	2.43	No	Yes	0	4	6
200	R:R:L235	R:R:R234	2.43	No	No	0	6	4
201	R:R:F161	R:R:N157	2.42	No	No	0	2	1
202	R:R:N153	R:R:R78	2.41	No	No	0	4	7
203	R:R:L255	R:R:Y225	2.34	No	Yes	0	8	6
204	R:R:L112	R:R:W117	2.28	No	Yes	0	5	9
205	R:R:G175	R:R:G176	2.11	No	No	0	6	4
206	R:R:R292	R:R:Y295	2.06	No	No	0	4	3
207	R:R:G176	R:R:P178	2.03	No	Yes	0	4	5
208	R:R:A88	R:R:G85	1.95	Yes	No	0	9	5
209	R:R:A94	R:R:G95	1.95	No	No	0	8	7
210	R:R:A270	R:R:P271	1.87	No	No	0	6	9
211	R:R:G175	R:R:V126	1.84	No	No	0	6	5
212	R:R:A127	R:R:A94	1.79	No	No	0	6	8
213	R:R:A127	R:R:A97	1.79	No	No	0	6	4
214	R:R:G85	R:R:I70	1.76	No	No	0	5	7
215	R:R:P196	R:R:T32	1.75	No	No	0	3	8
216	R:R:G181	R:R:M180	1.75	No	No	0	5	4
217	R:R:G33	R:R:K285	1.74	No	No	0	7	2
218	R:R:G33	R:R:L35	1.71	No	No	0	7	6
219	R:R:A130	R:R:S90	1.71	No	No	0	7	8
220	R:R:A94	R:R:S304	1.71	No	No	0	8	9
221	R:R:A97	R:R:S123	1.71	No	No	0	4	4
222	R:R:C222	R:R:V218	1.71	No	No	0	3	4
223	R:R:A88	R:R:V66	1.7	Yes	No	0	9	9
224	R:R:A293	R:R:V194	1.7	No	Yes	0	4	4
225	R:R:A100	R:R:T99	1.68	No	No	0	7	6
226	R:R:A115	R:R:T113	1.68	No	No	0	2	7
227	R:R:L160	R:R:P79	1.64	Yes	No	0	7	7
228	R:R:N157	R:R:P79	1.63	No	No	0	1	7
229	R:R:S131	R:R:S90	1.63	No	No	0	9	8
230	R:R:N307	R:R:P308	1.63	No	No	0	9	9
231	R:R:S192	R:R:V194	1.62	No	Yes	0	4	4
232	R:R:A107	R:R:K111	1.61	No	No	0	4	1
233	R:R:S49	R:R:T48	1.6	No	No	0	5	5
234	R:R:T193	R:R:V284	1.59	No	No	0	5	1
235	R:R:T257	R:R:V261	1.59	No	No	0	9	8
236	R:R:T306	R:R:V264	1.59	No	No	0	5	7
237	R:R:C282	R:R:L278	1.59	No	No	5	4	4
238	R:R:C287	R:R:L278	1.59	No	No	5	3	4
239	R:R:A88	R:R:L67	1.58	Yes	No	0	9	8
240	R:R:A300	R:R:L272	1.58	No	Yes	1	7	6
241	R:R:A300	R:R:L297	1.58	No	Yes	1	7	5
242	R:R:C268	R:R:N303	1.57	No	No	0	8	9
243	R:R:A88	R:R:N63	1.56	Yes	Yes	0	9	9
244	R:R:I185	R:R:S186	1.55	No	No	0	3	1
245	R:R:I25	R:R:V26	1.54	No	No	0	4	6
246	R:R:I170	R:R:V169	1.54	No	No	0	4	4
247	R:R:I310	R:R:V261	1.54	No	No	0	8	8
248	R:R:L213	R:R:V132	1.49	No	No	0	8	7
249	R:R:I185	R:R:I24	1.47	No	No	0	3	4
250	R:R:L68	R:R:T69	1.47	No	No	0	4	8
251	R:R:I140	R:R:I144	1.47	No	No	0	6	4
252	R:R:L212	R:R:T211	1.47	No	No	0	5	4
253	R:R:L313	R:R:T312	1.47	No	No	0	6	7
254	R:R:I179	R:R:M180	1.46	No	No	0	5	4
255	R:R:G122	R:R:Y198	1.45	No	Yes	0	6	4
256	R:R:K148	R:R:K150	1.44	No	No	0	6	7
257	R:R:I64	R:R:L61	1.43	No	No	0	4	4
258	R:R:I64	R:R:L92	1.43	No	Yes	0	4	6
259	R:R:I219	R:R:L220	1.43	No	No	0	4	7
260	R:R:L227	R:R:M146	1.41	No	No	0	6	8
261	R:R:D23	R:R:I24	1.4	No	No	0	7	4
262	R:R:C167	R:R:F133	1.4	No	No	0	6	5
263	R:R:L89	R:R:L93	1.38	No	No	0	5	6
264	R:R:L92	R:R:L93	1.38	Yes	No	0	6	6
265	R:R:L147	R:R:L227	1.38	No	No	0	6	6
266	R:R:L252	R:R:L255	1.38	No	No	0	5	8
267	R:R:L35	R:R:N30	1.37	No	No	0	6	9
268	R:R:E249	R:R:K250	1.35	No	No	0	5	6
269	R:R:R120	R:R:S105	1.32	Yes	No	0	6	4
270	R:R:R159	R:R:S155	1.32	No	No	0	5	7
271	R:R:F65	R:R:I325	1.26	No	No	0	7	6
272	R:R:I325	R:R:R324	1.25	No	No	0	6	4
273	R:R:K75	R:R:R320	1.24	No	No	0	6	5
274	R:R:F158	R:R:N156	1.21	No	No	0	4	7
275	L:L:?1	R:R:V209	1.11	Yes	No	0	0	5
276	R:R:R229	R:R:R233	1.07	No	No	0	5	4
277	R:R:H199	R:R:W182	1.06	Yes	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.5625	16	1	0
2	R:R:Y29	5.98	5	0	7
3	R:R:F52	5.55	4	0	6
4	R:R:N63	6.18	4	0	9
5	R:R:F76	9.0625	4	0	8
6	R:R:F83	5.598	5	0	8
7	R:R:A88	1.6975	4	0	9
8	R:R:L92	3.1325	4	0	6
9	R:R:Y98	6.0525	4	0	6
10	R:R:W117	7.16667	6	1	9
11	R:R:F118	6.8375	4	0	6
12	R:R:R120	5.132	5	0	6
13	R:R:E121	8.685	4	1	5
14	R:R:I138	4.105	4	0	8
15	R:R:L160	4.7725	4	0	7
16	R:R:P178	6.9575	4	1	5
17	R:R:L188	5.245	4	2	2
18	R:R:V194	2.81	5	1	4
19	R:R:L195	5.008	5	1	3
20	R:R:Y198	5.574	5	1	4
21	R:R:H199	7.045	4	0	4
22	R:R:Y202	5.96	4	1	7
23	R:R:Y225	3.7775	4	4	6
24	R:R:W269	8.02167	6	1	8
25	R:R:L272	3.144	5	1	6
26	R:R:L276	3.864	5	1	6
27	R:R:D279	3.155	4	0	4
28	R:R:L290	3.6375	4	0	3
29	R:R:L297	4.3325	4	1	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E121	22.0378	10.91	Yes	Yes	1	0	5
2	R:R:E121	R:R:Y198	13.5282	7.86	Yes	Yes	1	5	4
3	R:R:F118	R:R:Y198	18.7179	4.13	Yes	Yes	0	6	4
4	R:R:F118	R:R:N183	13.5982	8.46	Yes	No	0	6	5
5	R:R:I185	R:R:N183	12.1249	7.08	No	No	0	3	5
6	L:L:?1	R:R:L195	21.8823	6.21	Yes	Yes	1	0	3
7	R:R:L195	R:R:Y198	15.3436	4.69	Yes	Yes	1	3	4
8	R:R:L195	R:R:W117	11.0131	5.69	Yes	Yes	1	3	9
9	L:L:?1	R:R:L297	17.4545	8.29	Yes	Yes	1	0	5
10	R:R:L297	R:R:Y98	23.8843	4.69	Yes	Yes	0	5	6
11	R:R:F52	R:R:Y98	18.8695	4.13	Yes	Yes	0	6	6
12	R:R:F52	R:R:L102	10.3561	3.65	Yes	No	0	6	5
13	L:L:?1	R:R:W269	86.6934	4.26	Yes	Yes	1	0	8
14	R:R:N303	R:R:W269	100	9.04	No	Yes	0	9	8
15	R:R:N303	R:R:N307	99.0826	8.17	No	No	0	9	9
16	R:R:N307	R:R:P308	39.0452	1.63	No	No	0	9	9
17	R:R:D91	R:R:P308	37.9995	3.22	No	No	0	9	9
18	R:R:D91	R:R:N63	26.0418	13.46	No	Yes	0	9	9
19	R:R:L92	R:R:N63	16.9608	6.87	Yes	Yes	0	6	9
20	R:R:L135	R:R:N307	74.5296	4.12	No	No	0	9	9
21	R:R:L135	R:R:L87	49.4402	2.77	No	No	0	9	9
22	R:R:I138	R:R:L87	47.5432	2.85	Yes	No	0	8	9
23	R:R:F83	R:R:I138	35.6943	3.77	Yes	Yes	0	8	8
24	R:R:E141	R:R:F83	22.9474	10.49	No	Yes	0	9	8
25	R:R:E141	R:R:M80	20.6305	8.12	No	No	0	9	8
26	R:R:M80	R:R:R78	18.3175	3.72	No	No	0	8	7
27	R:R:R78	R:R:Y81	14.8616	14.4	No	No	0	7	9
28	R:R:F76	R:R:Y81	10.2861	18.57	Yes	No	0	8	9
29	R:R:F83	R:R:L160	11.9655	7.31	Yes	Yes	0	8	7
30	R:R:D91	R:R:S304	13.155	5.89	No	No	0	9	9
31	L:L:?1	R:R:F125	11.1763	25.52	Yes	No	1	0	5
32	R:R:F125	R:R:Y202	10.2356	5.16	No	Yes	1	5	7
33	L:L:?1	R:R:C206	11.2502	4.75	Yes	No	1	0	6
34	R:R:C206	R:R:Y202	10.3133	4.03	No	Yes	1	6	7
35	R:R:P178	R:R:Y198	10.1345	9.74	Yes	Yes	1	5	4
36	R:R:G176	R:R:P178	11.3785	2.03	No	Yes	0	4	5
37	R:R:V132	R:R:W269	11.6467	7.36	No	Yes	0	7	8
38	R:R:L213	R:R:V132	10.3833	1.49	No	No	0	8	7
39	R:R:I217	R:R:L135	35.0218	2.85	No	No	0	8	9
40	R:R:I217	R:R:L136	33.91	5.71	No	No	0	8	7
41	R:R:I140	R:R:L136	31.663	7.14	No	No	0	6	7
42	R:R:I138	R:R:Y311	10.3522	6.04	Yes	No	0	8	9
43	R:R:I140	R:R:L220	23.6355	2.85	No	No	0	6	7
44	R:R:L220	R:R:Y143	21.2486	4.69	No	No	0	7	8
45	R:R:L147	R:R:Y143	18.8268	3.52	No	No	0	6	8
46	R:R:L147	R:R:L227	17.5984	1.38	No	No	0	6	6
47	R:R:L227	R:R:M146	13.9831	1.41	No	No	0	6	8
48	R:R:M146	R:R:V228	11.4718	3.04	No	No	0	8	8
49	R:R:L177	R:R:Y202	12.467	3.52	No	Yes	1	5	7
50	R:R:L177	R:R:W182	12.9762	4.56	No	No	0	5	5
51	R:R:H199	R:R:W182	11.1452	1.06	Yes	No	0	4	5
52	L:L:?1	R:R:V194	11.9422	3.34	Yes	Yes	1	0	4
53	R:R:D279	R:R:V194	12.7119	2.92	Yes	Yes	0	4	4
54	R:R:D279	R:R:L290	22.1155	4.07	Yes	Yes	0	4	3
55	L:L:?1	R:R:L276	12.9723	5.18	Yes	Yes	1	0	6
56	R:R:D279	R:R:L276	18.0998	2.71	Yes	Yes	0	4	6
57	R:R:L254	R:R:V228	10.2045	4.47	No	No	0	8	8
58	R:R:C287	R:R:L290	11.153	4.76	No	Yes	0	3	3
59	R:R:L272	R:R:W269	17.0463	3.42	Yes	Yes	1	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:K34	3.17	1	Yes	No	0	6	0	1
L:L:?1	R:R:E121	10.91	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M124	5.29	1	Yes	No	0	6	0	1
L:L:?1	R:R:F125	25.52	1	Yes	No	0	5	0	1
L:L:?1	R:R:L128	7.25	1	Yes	No	0	6	0	1
L:L:?1	R:R:S129	3.37	1	Yes	No	0	6	0	1
L:L:?1	R:R:V194	3.34	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L195	6.21	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:C206	4.75	1	Yes	No	0	6	0	1
L:L:?1	R:R:F210	8.2	1	Yes	No	0	7	0	1
L:L:?1	R:R:W269	4.26	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L272	5.18	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L276	5.18	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:E294	2.97	1	Yes	No	0	3	0	1
L:L:?1	R:R:L297	8.29	1	Yes	Yes	0	5	0	1
R:R:K34	R:R:Y29	5.97	0	No	Yes	6	7	1	2
R:R:W117	R:R:Y29	5.79	1	Yes	Yes	9	7	2	2
R:R:L297	R:R:Y98	4.69	1	Yes	Yes	5	6	1	2
R:R:M124	R:R:N101	5.61	0	No	No	6	5	1	2
R:R:E121	R:R:W117	11.99	1	Yes	Yes	5	9	1	2
R:R:L195	R:R:W117	5.69	1	Yes	Yes	3	9	1	2
R:R:E121	R:R:L195	3.98	1	Yes	Yes	5	3	1	1
R:R:E121	R:R:Y198	7.86	1	Yes	Yes	5	4	1	2
R:R:F125	R:R:Y202	5.16	1	No	Yes	5	7	1	2
R:R:C206	R:R:F125	2.79	1	No	No	6	5	1	1
R:R:V132	R:R:W269	7.36	0	No	Yes	7	8	2	1
R:R:L195	R:R:V194	4.47	1	Yes	Yes	3	4	1	1
R:R:D279	R:R:V194	2.92	0	Yes	Yes	4	4	2	1
R:R:L195	R:R:Y198	4.69	1	Yes	Yes	3	4	1	2
R:R:C206	R:R:Y202	4.03	1	No	Yes	6	7	1	2
R:R:I203	R:R:L276	5.71	0	No	Yes	6	6	2	1
R:R:F273	R:R:T207	2.59	0	No	No	6	5	2	2
R:R:L276	R:R:T207	2.95	1	Yes	No	6	5	1	2
R:R:F210	R:R:W269	13.03	1	No	Yes	7	8	1	1
R:R:F210	R:R:F273	5.36	1	No	No	7	6	1	2
R:R:F265	R:R:W269	11.02	0	No	Yes	9	8	2	1
R:R:L272	R:R:W269	3.42	1	Yes	Yes	6	8	1	1
R:R:N303	R:R:W269	9.04	0	No	Yes	9	8	2	1
R:R:L272	R:R:L276	2.77	1	Yes	Yes	6	6	1	1
R:R:L272	R:R:L297	2.77	1	Yes	Yes	6	5	1	1
R:R:D279	R:R:L276	2.71	0	Yes	Yes	4	6	2	1
R:R:A293	R:R:V194	1.7	0	No	Yes	4	4	2	1
R:R:S192	R:R:V194	1.62	0	No	Yes	4	4	2	1
R:R:A300	R:R:L272	1.58	1	No	Yes	7	6	2	1
R:R:A300	R:R:L297	1.58	1	No	Yes	7	5	2	1
L:L:?1	R:R:V209	1.11	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EW0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.57
Number of Linked Nodes	262
Number of Links	277
Number of Hubs	29
Number of Links mediated by Hubs	110
Number of Communities	5
Number of Nodes involved in Communities	29
Number of Links involved in Communities	41

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	44491
Length Of Smallest Path	3
Average Path Length	12.5967
Length of Longest Path	27
Minimum Path Strength	1.255
Average Path Strength	5.36871
Maximum Path Strength	18.215
Minimum Path Correlation	0.7
Average Path Correlation	0.931697
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	56.3336
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.725
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JEU
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	JEU
Name	Ozanimod
Synonyms	Ozanimodum Ozanimod Ozanimod hydrochloride
Identifier
Formula	C23 H24 N4 O3
Molecular Weight	404.462
SMILES
PubChem	52938427
Formal Charge	0
Total Atoms	54
Total Chiral Atoms	1
Total Bonds	57
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7EW0_nogp_Chain_R Y D I I V R H Y N Y T G K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K M K L H N G S N N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F R K S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	doi.org/10.7554/eLife.88204
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-	Gi1/β1/γ2	2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-		2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-		2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EW0_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.