psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N101	9.09	Yes	Yes	1	0	5
2	L:L:?1	R:R:S105	9.94	Yes	Yes	1	0	4
3	L:L:?1	R:R:E121	4.39	Yes	Yes	1	0	5
4	L:L:?1	R:R:M124	6.55	Yes	No	1	0	6
5	L:L:?1	R:R:F125	17.74	Yes	No	1	0	5
6	L:L:?1	R:R:L128	6.42	Yes	No	0	0	6
7	L:L:?1	R:R:S129	7.95	Yes	No	0	0	6
8	L:L:?1	R:R:V132	3.95	Yes	No	0	0	7
9	L:L:?1	R:R:L195	3.67	Yes	Yes	1	0	3
10	L:L:?1	R:R:C206	7.36	Yes	No	1	0	6
11	L:L:?1	R:R:V209	2.96	Yes	No	0	0	5
12	L:L:?1	R:R:F210	5.65	Yes	No	0	0	7
13	L:L:?1	R:R:L276	4.58	Yes	No	0	0	6
14	L:L:?1	R:R:L297	4.58	Yes	No	0	0	5
15	R:R:D18	R:R:S17	2.94	No	No	0	6	7
16	R:R:D18	R:R:V20	10.22	No	No	0	6	5
17	R:R:D23	R:R:N21	5.39	No	No	0	7	8
18	R:R:T113	R:R:Y22	3.75	Yes	No	0	7	5
19	R:R:D23	R:R:R27	8.34	No	No	0	7	3
20	R:R:H28	R:R:I24	3.98	Yes	No	0	8	4
21	R:R:C184	R:R:H28	2.95	No	Yes	3	5	8
22	R:R:H28	R:R:L188	3.86	Yes	No	0	8	2
23	R:R:C191	R:R:H28	2.95	No	Yes	3	9	8
24	R:R:H28	R:R:L197	16.71	Yes	No	0	8	4
25	R:R:K34	R:R:Y29	3.58	No	Yes	4	6	7
26	R:R:T109	R:R:Y29	7.49	No	Yes	0	5	7
27	R:R:Y110	R:R:Y29	2.98	No	Yes	4	5	7
28	R:R:W117	R:R:Y29	2.89	Yes	Yes	0	9	7
29	R:R:P196	R:R:Y29	6.95	No	Yes	0	3	7
30	R:R:L35	R:R:N30	5.49	No	No	0	6	9
31	R:R:L188	R:R:Y31	8.21	No	No	0	2	5
32	R:R:G33	R:R:T32	3.64	No	No	0	7	8
33	R:R:P196	R:R:T32	3.5	No	No	0	3	8
34	R:R:I37	R:R:K34	4.36	No	No	0	1	6
35	R:R:K34	R:R:Y110	5.97	No	No	4	6	5
36	R:R:F52	R:R:T48	3.89	Yes	No	0	6	5
37	R:R:F52	R:R:V51	3.93	Yes	No	0	6	5
38	R:R:F52	R:R:Y98	6.19	Yes	Yes	1	6	6
39	R:R:F52	R:R:L102	3.65	Yes	No	1	6	5
40	R:R:F52	R:R:V298	7.87	Yes	No	1	6	5
41	R:R:I53	R:R:T99	3.04	No	No	0	3	6
42	R:R:C56	R:R:T99	3.38	No	No	0	5	6
43	R:R:E62	R:R:F58	10.49	No	No	0	8	4
44	R:R:I60	R:R:L92	4.28	No	No	0	6	6
45	R:R:E62	R:R:P308	3.14	No	Yes	0	8	9
46	R:R:D91	R:R:N63	12.12	Yes	No	0	9	9
47	R:R:L92	R:R:N63	2.75	No	No	0	6	9
48	R:R:N63	R:R:P308	4.89	No	Yes	0	9	9
49	R:R:I64	R:R:L92	5.71	No	No	0	4	6
50	R:R:F65	R:R:T69	5.19	No	No	6	7	8
51	R:R:F322	R:R:F65	18.22	No	No	6	7	7
52	R:R:A88	R:R:V66	3.39	No	No	0	9	9
53	R:R:P308	R:R:V66	3.53	Yes	No	0	9	9
54	R:R:A88	R:R:L67	3.15	No	No	0	9	8
55	R:R:F322	R:R:T69	10.38	No	No	6	7	8
56	R:R:I70	R:R:I84	2.94	No	No	0	7	8
57	R:R:I70	R:R:M318	2.92	No	No	0	7	8
58	R:R:K72	R:R:W71	17.4	No	No	0	6	3
59	R:R:K75	R:R:T73	4.5	No	No	0	6	6
60	R:R:F76	R:R:T73	11.67	No	No	0	8	6
61	R:R:F76	R:R:Y81	28.88	No	No	0	8	9
62	R:R:A321	R:R:F76	2.77	No	No	0	7	8
63	R:R:H77	R:R:Y82	3.27	No	No	0	7	4
64	R:R:R78	R:R:Y81	4.12	No	No	0	7	9
65	R:R:E141	R:R:M80	8.12	No	No	0	9	8
66	R:R:M80	R:R:R142	4.96	No	No	0	8	9
67	R:R:N315	R:R:Y81	4.65	No	No	0	8	9
68	R:R:A137	R:R:F83	2.77	No	Yes	0	7	8
69	R:R:F83	R:R:I138	3.77	Yes	No	0	8	8
70	R:R:E141	R:R:F83	5.83	No	Yes	0	9	8
71	R:R:F83	R:R:L160	3.65	Yes	No	0	8	7
72	R:R:N86	R:R:S134	5.96	No	No	0	9	8
73	R:R:I164	R:R:N86	9.91	No	No	0	7	9
74	R:R:N86	R:R:W168	3.39	No	No	0	9	9
75	R:R:D91	R:R:L87	4.07	Yes	Yes	5	9	9
76	R:R:L87	R:R:S134	7.51	Yes	No	0	9	8
77	R:R:L135	R:R:L87	4.15	No	Yes	0	9	9
78	R:R:I138	R:R:L87	2.85	No	Yes	0	8	9
79	R:R:L87	R:R:N307	5.49	Yes	No	5	9	9
80	R:R:A130	R:R:S90	3.42	No	No	0	7	8
81	R:R:S131	R:R:S90	4.89	No	No	0	9	8
82	R:R:D91	R:R:S131	2.94	Yes	No	0	9	9
83	R:R:D91	R:R:S304	7.36	Yes	No	0	9	9
84	R:R:D91	R:R:N307	4.04	Yes	No	5	9	9
85	R:R:A127	R:R:L93	3.15	No	No	0	6	6
86	R:R:L102	R:R:Y98	21.1	No	Yes	1	5	6
87	R:R:M124	R:R:Y98	4.79	No	Yes	1	6	6
88	R:R:L297	R:R:Y98	5.86	No	Yes	0	5	6
89	R:R:V298	R:R:Y98	3.79	No	Yes	1	5	6
90	R:R:V301	R:R:Y98	12.62	No	Yes	0	7	6
91	R:R:N101	R:R:S105	2.98	Yes	Yes	1	5	4
92	R:R:N101	R:R:R120	7.23	Yes	Yes	1	5	6
93	R:R:M124	R:R:N101	5.61	No	Yes	1	6	5
94	R:R:L104	R:R:L112	2.77	No	No	1	4	5
95	R:R:L104	R:R:Q116	3.99	No	Yes	1	4	4
96	R:R:L104	R:R:R120	4.86	No	Yes	1	4	6
97	R:R:G106	R:R:S105	3.71	No	Yes	0	4	4
98	R:R:R120	R:R:S105	6.59	Yes	Yes	1	6	4
99	R:R:K111	R:R:T108	6.01	No	No	0	1	4
100	R:R:R120	R:R:T109	5.17	Yes	No	0	6	5
101	R:R:L112	R:R:Q116	7.99	No	Yes	1	5	4
102	R:R:P114	R:R:T113	3.5	No	Yes	0	3	7
103	R:R:A115	R:R:T113	3.36	No	Yes	0	2	7
104	R:R:Q116	R:R:T113	2.83	Yes	Yes	0	4	7
105	R:R:L119	R:R:Q116	9.32	No	Yes	0	4	4
106	R:R:F118	R:R:W117	5.01	Yes	Yes	0	6	9
107	R:R:R120	R:R:W117	3	Yes	Yes	0	6	9
108	R:R:E121	R:R:W117	8.72	Yes	Yes	0	5	9
109	R:R:L197	R:R:W117	5.69	No	Yes	0	4	9
110	R:R:F118	R:R:P178	4.33	Yes	Yes	0	6	5
111	R:R:F118	R:R:I179	3.77	Yes	No	0	6	5
112	R:R:F118	R:R:N183	3.62	Yes	No	0	6	5
113	R:R:E121	R:R:L195	9.28	Yes	Yes	1	5	3
114	R:R:E121	R:R:Y198	8.98	Yes	Yes	1	5	4
115	R:R:F125	R:R:Y202	6.19	No	Yes	1	5	7
116	R:R:C206	R:R:F125	2.79	No	No	1	6	5
117	R:R:S171	R:R:V126	4.85	No	No	0	8	5
118	R:R:L128	R:R:W269	5.69	No	Yes	0	6	8
119	R:R:S129	R:R:S171	4.89	No	No	0	6	8
120	R:R:L213	R:R:V132	4.47	No	No	0	8	7
121	R:R:V132	R:R:W269	3.68	No	Yes	0	7	8
122	R:R:C167	R:R:W133	3.92	No	No	0	6	5
123	R:R:I170	R:R:W133	7.05	No	No	0	4	5
124	R:R:L213	R:R:W133	9.11	No	No	0	8	5
125	R:R:F265	R:R:L135	3.65	No	No	0	9	9
126	R:R:L135	R:R:Y311	3.52	No	Yes	0	9	9
127	R:R:I140	R:R:L136	5.71	No	No	0	6	7
128	R:R:I217	R:R:L136	5.71	No	No	0	8	7
129	R:R:A139	R:R:Y221	4	No	Yes	0	8	9
130	R:R:E141	R:R:T145	5.64	No	No	0	9	8
131	R:R:R142	R:R:Y221	8.23	No	Yes	7	9	9
132	R:R:R142	R:R:Y311	4.12	No	Yes	7	9	9
133	R:R:L220	R:R:Y143	3.52	No	No	0	7	8
134	R:R:R223	R:R:Y143	13.38	No	No	0	5	8
135	R:R:I224	R:R:Y143	3.63	No	No	0	9	8
136	R:R:K148	R:R:R231	7.43	No	No	0	6	7
137	R:R:L163	R:R:R159	3.64	No	No	0	6	5
138	R:R:F161	R:R:L160	7.31	No	No	0	2	7
139	R:R:I170	R:R:L174	2.85	No	No	0	4	5
140	R:R:F205	R:R:L174	3.65	No	No	0	5	5
141	R:R:L177	R:R:M180	2.83	No	No	0	5	4
142	R:R:P178	R:R:Y198	9.74	Yes	Yes	1	5	4
143	R:R:P178	R:R:Y202	9.74	Yes	Yes	1	5	7
144	R:R:H201	R:R:W182	8.46	No	No	0	4	5
145	R:R:I185	R:R:N183	19.82	No	No	0	3	5
146	R:R:C184	R:R:C191	7.28	No	No	3	5	9
147	R:R:H199	R:R:S190	9.76	No	No	0	4	4
148	R:R:D279	R:R:T193	5.78	Yes	No	2	4	5
149	R:R:L290	R:R:T193	10.32	Yes	No	2	3	5
150	R:R:L195	R:R:V194	4.47	Yes	No	0	3	4
151	R:R:L195	R:R:Y198	5.86	Yes	Yes	1	3	4
152	R:R:Y198	R:R:Y202	12.91	Yes	Yes	1	4	7
153	R:R:H199	R:R:H201	3.58	No	No	0	4	4
154	R:R:K200	R:R:V280	6.07	No	Yes	0	3	4
155	R:R:L204	R:R:V280	4.47	No	Yes	0	5	4
156	R:R:F273	R:R:T207	6.49	No	No	0	6	5
157	R:R:L277	R:R:T207	4.42	No	No	0	6	5
158	R:R:F210	R:R:W269	12.03	No	Yes	0	7	8
159	R:R:F210	R:R:F273	10.72	No	No	0	7	6
160	R:R:F265	R:R:L214	3.65	No	No	0	9	5
161	R:R:I266	R:R:L214	4.28	No	No	0	6	5
162	R:R:L262	R:R:V218	4.47	Yes	No	0	7	4
163	R:R:C222	R:R:I219	3.27	No	No	0	3	4
164	R:R:Y221	R:R:Y311	2.98	Yes	Yes	7	9	9
165	R:R:R229	R:R:Y225	5.14	No	No	0	5	6
166	R:R:L254	R:R:Y225	4.69	No	No	0	8	6
167	R:R:L255	R:R:Y225	17.58	No	No	0	8	6
168	R:R:R229	R:R:S226	3.95	No	No	0	5	3
169	R:R:L227	R:R:R231	7.29	No	No	0	6	7
170	R:R:R229	R:R:T230	6.47	No	No	0	5	5
171	R:R:F237	R:R:L235	6.09	No	No	0	3	6
172	R:R:L252	R:R:S251	3	No	No	0	5	7
173	R:R:T257	R:R:T314	4.71	No	No	0	9	7
174	R:R:L262	R:R:V258	2.98	Yes	No	0	7	8
175	R:R:I260	R:R:I310	4.42	No	No	0	6	8
176	R:R:L262	R:R:V261	2.98	Yes	No	0	7	8
177	R:R:T306	R:R:V264	4.76	No	No	0	5	7
178	R:R:I310	R:R:V264	4.61	No	No	0	8	7
179	R:R:F265	R:R:W269	3.01	No	Yes	0	9	8
180	R:R:C268	R:R:N303	3.15	No	Yes	0	8	9
181	R:R:N303	R:R:W269	6.78	Yes	Yes	0	9	8
182	R:R:L272	R:R:L276	2.77	No	No	0	6	6
183	R:R:F296	R:R:L275	10.96	No	No	0	4	4
184	R:R:D279	R:R:L290	6.79	Yes	Yes	2	4	3
185	R:R:C282	R:R:T286	3.38	No	No	2	4	1
186	R:R:C282	R:R:C287	7.28	No	No	2	4	3
187	R:R:C282	R:R:L290	3.17	No	Yes	2	4	3
188	R:R:K283	R:R:T286	4.5	No	No	0	1	1
189	R:R:K285	R:R:V284	7.59	No	No	0	2	1
190	R:R:C287	R:R:T286	3.38	No	No	2	3	1
191	R:R:C287	R:R:L290	7.94	No	Yes	2	3	3
192	R:R:F291	R:R:R292	5.34	No	No	0	1	4
193	R:R:N303	R:R:T306	4.39	Yes	No	0	9	5
194	R:R:N303	R:R:N307	12.26	Yes	No	0	9	9
195	R:R:L313	R:R:T312	2.95	No	No	0	6	7
196	R:R:M318	R:R:T312	7.53	No	No	0	8	7
197	R:R:F322	R:R:T312	7.78	No	No	0	7	7
198	R:R:E317	R:R:N315	5.26	No	No	0	7	8
199	R:R:M318	R:R:N315	4.21	No	No	0	8	8
200	R:R:E317	R:R:K316	20.25	No	No	0	7	6
201	R:R:K316	R:R:R319	3.71	No	No	0	6	8
202	R:R:D18	R:R:N21	2.69	No	No	0	6	8
203	R:R:C56	R:R:Y98	2.69	No	Yes	0	5	6
204	R:R:H199	R:R:K200	2.62	No	No	0	4	3
205	R:R:F291	R:R:T193	2.59	No	No	0	1	5
206	R:R:F273	R:R:T211	2.59	No	No	0	6	4
207	R:R:I289	R:R:R292	2.51	No	No	0	3	4
208	R:R:T48	R:R:Y295	2.5	No	No	0	5	3
209	R:R:F158	R:R:L162	2.44	No	No	0	4	3
210	R:R:I25	R:R:Y29	2.42	No	Yes	0	4	7
211	R:R:I84	R:R:Y311	2.42	No	Yes	0	8	9
212	R:R:I224	R:R:Y221	2.42	No	Yes	0	9	9
213	R:R:L35	R:R:Y110	2.34	No	No	0	6	5
214	R:R:L262	R:R:Y221	2.34	Yes	Yes	0	7	9
215	R:R:L93	R:R:W168	2.28	No	No	0	6	9
216	R:R:L177	R:R:W182	2.28	No	No	0	5	5
217	R:R:E294	R:R:Y295	2.24	No	No	0	3	3
218	R:R:G175	R:R:G176	2.11	No	No	0	6	4
219	R:R:G176	R:R:P178	2.03	No	Yes	0	4	5
220	R:R:G305	R:R:P308	2.03	No	Yes	0	7	9
221	R:R:A88	R:R:G85	1.95	No	No	0	9	5
222	R:R:A94	R:R:G95	1.95	No	No	0	8	7
223	R:R:W182	R:R:Y202	1.93	No	Yes	0	5	7
224	R:R:A270	R:R:P271	1.87	No	No	0	6	9
225	R:R:G281	R:R:V280	1.84	No	Yes	0	4	4
226	R:R:A127	R:R:A94	1.79	No	No	0	6	8
227	R:R:G305	R:R:I59	1.76	No	No	0	7	7
228	R:R:G33	R:R:K285	1.74	No	No	0	7	2
229	R:R:A97	R:R:S123	1.71	No	No	0	4	4
230	R:R:A187	R:R:S186	1.71	No	No	0	4	1
231	R:R:A293	R:R:V194	1.7	No	No	0	4	4
232	R:R:C57	R:R:I53	1.64	No	No	0	5	3
233	R:R:E121	R:R:G122	1.64	Yes	No	0	5	6
234	R:R:L299	R:R:P271	1.64	No	No	0	7	9
235	R:R:A139	R:R:I217	1.62	No	No	0	8	8
236	R:R:S165	R:R:V169	1.62	No	No	0	4	4
237	R:R:S263	R:R:V264	1.62	No	No	0	5	7
238	R:R:S49	R:R:T48	1.6	No	No	0	5	5
239	R:R:T99	R:R:V96	1.59	No	No	0	6	5
240	R:R:T208	R:R:V209	1.59	No	No	0	4	5
241	R:R:T257	R:R:V258	1.59	No	No	0	9	8
242	R:R:A300	R:R:L272	1.58	No	No	0	7	6
243	R:R:A293	R:R:L275	1.58	No	No	0	4	4
244	R:R:I55	R:R:V51	1.54	No	No	0	6	5
245	R:R:I173	R:R:V169	1.54	No	No	0	4	4
246	R:R:I203	R:R:V280	1.54	No	Yes	0	6	4
247	R:R:M146	R:R:V228	1.52	No	No	0	8	8
248	R:R:M146	R:R:T145	1.51	No	No	0	8	8
249	R:R:L136	R:R:S216	1.5	No	No	0	7	6
250	R:R:L35	R:R:V26	1.49	No	No	0	6	6
251	R:R:L54	R:R:V50	1.49	No	No	0	4	5
252	R:R:L172	R:R:V126	1.49	No	No	0	4	5
253	R:R:L252	R:R:V228	1.49	No	No	0	5	8
254	R:R:D279	R:R:S192	1.47	Yes	No	0	4	4
255	R:R:L302	R:R:T306	1.47	No	No	0	6	5
256	R:R:D279	R:R:V194	1.46	Yes	No	0	4	4
257	R:R:P79	R:R:R78	1.44	No	No	0	7	7
258	R:R:F83	R:R:P79	1.44	Yes	No	0	8	7
259	R:R:I53	R:R:L103	1.43	No	No	0	3	6
260	R:R:I140	R:R:L163	1.43	No	No	0	6	6
261	R:R:I259	R:R:L255	1.43	No	No	0	5	8
262	R:R:I309	R:R:L313	1.43	No	No	0	6	6
263	R:R:L227	R:R:M146	1.41	No	No	0	6	8
264	R:R:L147	R:R:M149	1.41	No	No	0	6	8
265	R:R:D288	R:R:I289	1.4	No	No	0	3	3
266	R:R:L299	R:R:L302	1.38	No	No	0	7	6
267	R:R:R233	R:R:S232	1.32	No	No	0	4	5
268	R:R:F237	R:R:S232	1.32	No	No	0	3	5
269	R:R:I323	R:R:R320	1.25	No	No	0	3	5
270	R:R:L252	R:R:R233	1.21	No	No	0	5	4
271	R:R:L160	R:R:Y82	1.17	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.77357	14	1	0
2	R:R:H28	6.09	5	3	8
3	R:R:Y29	4.385	6	4	7
4	R:R:F52	5.106	5	1	6
5	R:R:F83	3.492	5	0	8
6	R:R:L87	4.814	5	5	9
7	R:R:D91	6.106	5	5	9
8	R:R:Y98	8.14857	7	1	6
9	R:R:N101	6.2275	4	1	5
10	R:R:S105	5.805	4	1	4
11	R:R:T113	3.36	4	0	7
12	R:R:Q116	6.0325	4	1	4
13	R:R:W117	5.062	5	0	9
14	R:R:F118	4.1825	4	0	6
15	R:R:R120	5.37	5	1	6
16	R:R:E121	6.602	5	1	5
17	R:R:P178	6.46	4	1	5
18	R:R:L195	5.82	4	1	3
19	R:R:Y198	9.3725	4	1	4
20	R:R:Y202	7.6925	4	1	7
21	R:R:Y221	3.994	5	7	9
22	R:R:L262	3.1925	4	0	7
23	R:R:W269	6.238	5	0	8
24	R:R:D279	3.875	4	2	4
25	R:R:V280	3.48	4	0	4
26	R:R:L290	7.055	4	2	3
27	R:R:N303	6.645	4	0	9
28	R:R:P308	3.3975	4	0	9
29	R:R:Y311	3.26	4	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N101	14.5163	9.09	Yes	Yes	1	0	5
2	R:R:N101	R:R:R120	15.6021	7.23	Yes	Yes	1	5	6
3	R:R:L104	R:R:R120	23.686	4.86	No	Yes	1	4	6
4	R:R:L104	R:R:Q116	17.779	3.99	No	Yes	1	4	4
5	R:R:Q116	R:R:T113	11.882	2.83	Yes	Yes	0	4	7
6	L:L:?1	R:R:S105	16.0018	9.94	Yes	Yes	1	0	4
7	R:R:R120	R:R:S105	13.4982	6.59	Yes	Yes	1	6	4
8	L:L:?1	R:R:E121	41.2739	4.39	Yes	Yes	1	0	5
9	R:R:E121	R:R:W117	36.3824	8.72	Yes	Yes	0	5	9
10	R:R:L197	R:R:W117	11.1807	5.69	No	Yes	0	4	9
11	R:R:W117	R:R:Y29	20.6822	2.89	Yes	Yes	0	9	7
12	L:L:?1	R:R:M124	25.9256	6.55	Yes	No	1	0	6
13	R:R:M124	R:R:Y98	26.7074	4.79	No	Yes	1	6	6
14	R:R:F52	R:R:Y98	21.2352	6.19	Yes	Yes	1	6	6
15	L:L:?1	R:R:L297	25.9784	4.58	Yes	No	0	0	5
16	R:R:L297	R:R:Y98	24.5281	5.86	No	Yes	0	5	6
17	R:R:F52	R:R:T48	12.1836	3.89	Yes	No	0	6	5
18	R:R:C56	R:R:Y98	18.2465	2.69	No	Yes	0	5	6
19	R:R:C56	R:R:T99	15.2176	3.38	No	No	0	5	6
20	L:L:?1	R:R:L128	55.6393	6.42	Yes	No	0	0	6
21	R:R:L128	R:R:W269	55.6871	5.69	No	Yes	0	6	8
22	R:R:N303	R:R:W269	72.443	6.78	Yes	Yes	0	9	8
23	R:R:N303	R:R:N307	62.019	12.26	Yes	No	0	9	9
24	R:R:D91	R:R:N307	20.177	4.04	Yes	No	5	9	9
25	R:R:D91	R:R:N63	17.3164	12.12	Yes	No	0	9	9
26	R:R:N63	R:R:P308	12.078	4.89	No	Yes	0	9	9
27	L:L:?1	R:R:V132	57.8262	3.95	Yes	No	0	0	7
28	R:R:V132	R:R:W269	58.1605	3.68	No	Yes	0	7	8
29	L:L:?1	R:R:F210	57.1651	5.65	Yes	No	0	0	7
30	R:R:F210	R:R:W269	57.4039	12.03	No	Yes	0	7	8
31	R:R:F265	R:R:W269	100	3.01	No	Yes	0	9	8
32	R:R:F265	R:R:L135	97.4512	3.65	No	No	0	9	9
33	R:R:L135	R:R:Y311	60.7772	3.52	No	Yes	0	9	9
34	R:R:I84	R:R:Y311	22.668	2.42	No	Yes	0	8	9
35	R:R:I70	R:R:I84	21.3659	2.94	No	No	0	7	8
36	R:R:I70	R:R:M318	20.0739	2.92	No	No	0	7	8
37	R:R:L135	R:R:L87	42.7419	4.15	No	Yes	0	9	9
38	R:R:I138	R:R:L87	61.2598	2.85	No	Yes	0	8	9
39	R:R:F83	R:R:I138	58.995	3.77	Yes	No	0	8	8
40	R:R:F83	R:R:P79	17.2486	1.44	Yes	No	0	8	7
41	R:R:P79	R:R:R78	14.8958	1.44	No	No	0	7	7
42	R:R:R78	R:R:Y81	12.5456	4.12	No	No	0	7	9
43	R:R:F76	R:R:Y81	13.9356	28.88	No	No	0	8	9
44	R:R:L87	R:R:N307	40.9572	5.49	Yes	No	5	9	9
45	R:R:M318	R:R:N315	11.4672	4.21	No	No	0	8	8
46	R:R:E141	R:R:F83	30.1159	5.83	No	Yes	0	9	8
47	R:R:R142	R:R:Y311	16.5196	4.12	No	Yes	7	9	9
48	R:R:M80	R:R:R142	16.3763	4.96	No	No	0	8	9
49	R:R:E141	R:R:M80	15.3307	8.12	No	No	0	9	8
50	R:R:L87	R:R:S134	19.4832	7.51	Yes	No	0	9	8
51	R:R:N86	R:R:S134	17.0651	5.96	No	No	0	9	8
52	R:R:N86	R:R:W168	12.2138	3.39	No	No	0	9	9
53	L:L:?1	R:R:L195	31.8126	3.67	Yes	Yes	1	0	3
54	L:L:?1	R:R:F125	22.1024	17.74	Yes	No	1	0	5
55	R:R:F125	R:R:Y202	20.6897	6.19	No	Yes	1	5	7
56	R:R:Y221	R:R:Y311	22.9772	2.98	Yes	Yes	7	9	9
57	R:R:E141	R:R:T145	40.7662	5.64	No	No	0	9	8
58	R:R:M146	R:R:T145	37.4733	1.51	No	No	0	8	8
59	R:R:L227	R:R:M146	10.3336	1.41	No	No	0	6	8
60	R:R:W182	R:R:Y202	18.1082	1.93	No	Yes	0	5	7
61	R:R:H201	R:R:W182	13.2293	8.46	No	No	0	4	5
62	R:R:H199	R:R:H201	11.5929	3.58	No	No	0	4	4
63	R:R:L195	R:R:V194	27.8662	4.47	Yes	No	0	3	4
64	R:R:D279	R:R:V194	21.9566	1.46	Yes	No	0	4	4
65	R:R:D279	R:R:L290	11.0122	6.79	Yes	Yes	2	4	3
66	R:R:M146	R:R:V228	23.7187	1.52	No	No	0	8	8
67	R:R:L252	R:R:V228	20.5113	1.49	No	No	0	5	8
68	R:R:L252	R:R:R233	13.7596	1.21	No	No	0	5	4
69	R:R:R233	R:R:S232	10.5422	1.32	No	No	0	4	5
70	R:R:N303	R:R:T306	12.8698	4.39	Yes	No	0	9	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:N101	9.09	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:S105	9.94	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:E121	4.39	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M124	6.55	1	Yes	No	0	6	0	1
L:L:?1	R:R:F125	17.74	1	Yes	No	0	5	0	1
L:L:?1	R:R:L128	6.42	1	Yes	No	0	6	0	1
L:L:?1	R:R:S129	7.95	1	Yes	No	0	6	0	1
L:L:?1	R:R:V132	3.95	1	Yes	No	0	7	0	1
L:L:?1	R:R:L195	3.67	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:C206	7.36	1	Yes	No	0	6	0	1
L:L:?1	R:R:V209	2.96	1	Yes	No	0	5	0	1
L:L:?1	R:R:F210	5.65	1	Yes	No	0	7	0	1
L:L:?1	R:R:L276	4.58	1	Yes	No	0	6	0	1
L:L:?1	R:R:L297	4.58	1	Yes	No	0	5	0	1
R:R:M124	R:R:Y98	4.79	1	No	Yes	6	6	1	2
R:R:L297	R:R:Y98	5.86	0	No	Yes	5	6	1	2
R:R:N101	R:R:S105	2.98	1	Yes	Yes	5	4	1	1
R:R:N101	R:R:R120	7.23	1	Yes	Yes	5	6	1	2
R:R:M124	R:R:N101	5.61	1	No	Yes	6	5	1	1
R:R:G106	R:R:S105	3.71	0	No	Yes	4	4	2	1
R:R:R120	R:R:S105	6.59	1	Yes	Yes	6	4	2	1
R:R:R120	R:R:W117	3	1	Yes	Yes	6	9	2	2
R:R:E121	R:R:W117	8.72	1	Yes	Yes	5	9	1	2
R:R:E121	R:R:L195	9.28	1	Yes	Yes	5	3	1	1
R:R:E121	R:R:Y198	8.98	1	Yes	Yes	5	4	1	2
R:R:F125	R:R:Y202	6.19	1	No	Yes	5	7	1	2
R:R:C206	R:R:F125	2.79	1	No	No	6	5	1	1
R:R:L128	R:R:W269	5.69	0	No	Yes	6	8	1	2
R:R:S129	R:R:S171	4.89	0	No	No	6	8	1	2
R:R:L213	R:R:V132	4.47	0	No	No	8	7	2	1
R:R:V132	R:R:W269	3.68	0	No	Yes	7	8	1	2
R:R:L195	R:R:V194	4.47	1	Yes	No	3	4	1	2
R:R:L195	R:R:Y198	5.86	1	Yes	Yes	3	4	1	2
R:R:Y198	R:R:Y202	12.91	1	Yes	Yes	4	7	2	2
R:R:F210	R:R:W269	12.03	0	No	Yes	7	8	1	2
R:R:F210	R:R:F273	10.72	0	No	No	7	6	1	2
R:R:L272	R:R:L276	2.77	0	No	No	6	6	2	1
R:R:E121	R:R:G122	1.64	1	Yes	No	5	6	1	2
R:R:T208	R:R:V209	1.59	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EO4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.75
Number of Linked Nodes	256
Number of Links	271
Number of Hubs	29
Number of Links mediated by Hubs	116
Number of Communities	7
Number of Nodes involved in Communities	40
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	85259
Length Of Smallest Path	3
Average Path Length	13.1706
Length of Longest Path	25
Minimum Path Strength	1.265
Average Path Strength	5.22635
Maximum Path Strength	20.275
Minimum Path Correlation	0.7
Average Path Correlation	0.938323
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	57.0497
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.0108
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • biological regulation • cellular process • lamellipodium assembly • plasma membrane bounded cell projection organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component organization • cellular component biogenesis • cellular component assembly • lamellipodium organization • cellular component organization or biogenesis • cell projection assembly • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of actin filament-based process • negative regulation of biological process • regulation of actin filament bundle assembly • actin filament bundle organization • actin filament-based process • negative regulation of cellular process • stress fiber assembly • negative regulation of supramolecular fiber organization • regulation of actin filament organization • negative regulation of stress fiber assembly • actin cytoskeleton organization • actomyosin structure organization • negative regulation of cellular component organization • negative regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • negative regulation of actin filament bundle assembly • regulation of organelle organization • regulation of stress fiber assembly • organelle organization • negative regulation of organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • cell population proliferation • heart trabecula morphogenesis • trabecula morphogenesis • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • cellular developmental process • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • homeostatic process • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • regulation of multicellular organismal process • regulation of multicellular organismal development • regulation of developmental process • bone mineralization • regulation of biomineral tissue development • regulation of bone mineralization • ossification • biomineral tissue development • regulation of ossification • cellular response to stimulus • response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • chemotaxis • taxis • response to chemical • response to external stimulus • locomotion • metabolic process • regulation of metabolic process • positive chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of positive chemotaxis • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • regulation of positive chemotaxis • positive regulation of response to external stimulus • regulation of response to stimulus • regulation of locomotion • system process • nervous system process • transmission of nerve impulse • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • positive regulation of cellular process • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • developmental growth • heart morphogenesis • organ growth • striated muscle tissue development • muscle structure development • cardiac muscle tissue growth involved in heart morphogenesis • animal organ morphogenesis • cardiac muscle tissue growth • muscle tissue development • muscle organ development • heart development • heart growth • cardiac muscle tissue development • growth • muscle tissue morphogenesis • developmental growth involved in morphogenesis • tissue morphogenesis • cardiac muscle tissue morphogenesis • growth involved in heart morphogenesis • muscle organ morphogenesis • cell chemotaxis • cellular response to chemical stimulus • leukocyte chemotaxis • sphingolipid mediated signaling pathway • sphingosine-1-phosphate receptor signaling pathway • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • blood vessel maturation • developmental maturation • anatomical structure maturation • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • membrane microdomain • membrane raft
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • membrane microdomain • membrane raft • presynapse • synapse • cell junction • cytoplasm • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • vesicle • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J8C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	J8C
Name	Siponimod
Synonyms	Siponimod fumarate Siponimod
Identifier
Formula	C29 H35 F3 N2 O3
Molecular Weight	516.595
SMILES
PubChem	72959169
Formal Charge	0
Total Atoms	72
Total Chiral Atoms	0
Total Bonds	75
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7EO4_nogp_Chain_R S D Y V N Y D I I V R H Y N Y T G K L N I K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V W S L L A I A I E R Y I T M L K M K N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F R S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	10.7554/eLife.88204
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-		2.83	2022-09-28	10.1073/pnas.2117716119
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	10.1073/pnas.2117716119
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	10.1038/s41467-022-28417-2
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	10.1038/s41467-022-28417-2
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-	Gi1/β1/γ2	2.86	2022-01-05	10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-		2.86	2022-01-05	10.1038/s41589-021-00930-3
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	10.1038/s41589-021-00930-3
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	10.1038/s41422-021-00566-x
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	10.1038/s41422-021-00566-x
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	10.1126/science.1215904
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	10.1126/science.1215904

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