psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N101	9.09	Yes	Yes	1	0	5
2	L:L:?1	R:R:S105	9.94	Yes	Yes	1	0	4
3	L:L:?1	R:R:E121	4.39	Yes	Yes	1	0	5
4	L:L:?1	R:R:M124	6.55	Yes	No	1	0	6
5	L:L:?1	R:R:F125	17.74	Yes	No	1	0	5
6	L:L:?1	R:R:L128	6.42	Yes	No	0	0	6
7	L:L:?1	R:R:S129	7.95	Yes	No	0	0	6
8	L:L:?1	R:R:V132	3.95	Yes	No	0	0	7
9	L:L:?1	R:R:L195	3.67	Yes	Yes	1	0	3
10	L:L:?1	R:R:C206	7.36	Yes	No	1	0	6
11	L:L:?1	R:R:V209	2.96	Yes	No	0	0	5
12	L:L:?1	R:R:F210	5.65	Yes	No	0	0	7
13	L:L:?1	R:R:L276	4.58	Yes	No	0	0	6
14	L:L:?1	R:R:L297	4.58	Yes	No	0	0	5
15	R:R:D18	R:R:S17	2.94	No	No	0	6	7
16	R:R:D18	R:R:V20	10.22	No	No	0	6	5
17	R:R:D23	R:R:N21	5.39	No	No	0	7	8
18	R:R:T113	R:R:Y22	3.75	Yes	No	0	7	5
19	R:R:D23	R:R:R27	8.34	No	No	0	7	3
20	R:R:H28	R:R:I24	3.98	Yes	No	0	8	4
21	R:R:C184	R:R:H28	2.95	No	Yes	3	5	8
22	R:R:H28	R:R:L188	3.86	Yes	No	0	8	2
23	R:R:C191	R:R:H28	2.95	No	Yes	3	9	8
24	R:R:H28	R:R:L197	16.71	Yes	No	0	8	4
25	R:R:K34	R:R:Y29	3.58	No	Yes	4	6	7
26	R:R:T109	R:R:Y29	7.49	No	Yes	0	5	7
27	R:R:Y110	R:R:Y29	2.98	No	Yes	4	5	7
28	R:R:W117	R:R:Y29	2.89	Yes	Yes	0	9	7
29	R:R:P196	R:R:Y29	6.95	No	Yes	0	3	7
30	R:R:L35	R:R:N30	5.49	No	No	0	6	9
31	R:R:L188	R:R:Y31	8.21	No	No	0	2	5
32	R:R:G33	R:R:T32	3.64	No	No	0	7	8
33	R:R:P196	R:R:T32	3.5	No	No	0	3	8
34	R:R:I37	R:R:K34	4.36	No	No	0	1	6
35	R:R:K34	R:R:Y110	5.97	No	No	4	6	5
36	R:R:F52	R:R:T48	3.89	Yes	No	0	6	5
37	R:R:F52	R:R:V51	3.93	Yes	No	0	6	5
38	R:R:F52	R:R:Y98	6.19	Yes	Yes	1	6	6
39	R:R:F52	R:R:L102	3.65	Yes	No	1	6	5
40	R:R:F52	R:R:V298	7.87	Yes	No	1	6	5
41	R:R:I53	R:R:T99	3.04	No	No	0	3	6
42	R:R:C56	R:R:T99	3.38	No	No	0	5	6
43	R:R:E62	R:R:F58	10.49	No	No	0	8	4
44	R:R:I60	R:R:L92	4.28	No	No	0	6	6
45	R:R:E62	R:R:P308	3.14	No	Yes	0	8	9
46	R:R:D91	R:R:N63	12.12	Yes	No	0	9	9
47	R:R:L92	R:R:N63	2.75	No	No	0	6	9
48	R:R:N63	R:R:P308	4.89	No	Yes	0	9	9
49	R:R:I64	R:R:L92	5.71	No	No	0	4	6
50	R:R:F65	R:R:T69	5.19	No	No	6	7	8
51	R:R:F322	R:R:F65	18.22	No	No	6	7	7
52	R:R:A88	R:R:V66	3.39	No	No	0	9	9
53	R:R:P308	R:R:V66	3.53	Yes	No	0	9	9
54	R:R:A88	R:R:L67	3.15	No	No	0	9	8
55	R:R:F322	R:R:T69	10.38	No	No	6	7	8
56	R:R:I70	R:R:I84	2.94	No	No	0	7	8
57	R:R:I70	R:R:M318	2.92	No	No	0	7	8
58	R:R:K72	R:R:W71	17.4	No	No	0	6	3
59	R:R:K75	R:R:T73	4.5	No	No	0	6	6
60	R:R:F76	R:R:T73	11.67	No	No	0	8	6
61	R:R:F76	R:R:Y81	28.88	No	No	0	8	9
62	R:R:A321	R:R:F76	2.77	No	No	0	7	8
63	R:R:H77	R:R:Y82	3.27	No	No	0	7	4
64	R:R:R78	R:R:Y81	4.12	No	No	0	7	9
65	R:R:E141	R:R:M80	8.12	No	No	0	9	8
66	R:R:M80	R:R:R142	4.96	No	No	0	8	9
67	R:R:N315	R:R:Y81	4.65	No	No	0	8	9
68	R:R:A137	R:R:F83	2.77	No	Yes	0	7	8
69	R:R:F83	R:R:I138	3.77	Yes	No	0	8	8
70	R:R:E141	R:R:F83	5.83	No	Yes	0	9	8
71	R:R:F83	R:R:L160	3.65	Yes	No	0	8	7
72	R:R:N86	R:R:S134	5.96	No	No	0	9	8
73	R:R:I164	R:R:N86	9.91	No	No	0	7	9
74	R:R:N86	R:R:W168	3.39	No	No	0	9	9
75	R:R:D91	R:R:L87	4.07	Yes	Yes	5	9	9
76	R:R:L87	R:R:S134	7.51	Yes	No	0	9	8
77	R:R:L135	R:R:L87	4.15	No	Yes	0	9	9
78	R:R:I138	R:R:L87	2.85	No	Yes	0	8	9
79	R:R:L87	R:R:N307	5.49	Yes	No	5	9	9
80	R:R:A130	R:R:S90	3.42	No	No	0	7	8
81	R:R:S131	R:R:S90	4.89	No	No	0	9	8
82	R:R:D91	R:R:S131	2.94	Yes	No	0	9	9
83	R:R:D91	R:R:S304	7.36	Yes	No	0	9	9
84	R:R:D91	R:R:N307	4.04	Yes	No	5	9	9
85	R:R:A127	R:R:L93	3.15	No	No	0	6	6
86	R:R:L102	R:R:Y98	21.1	No	Yes	1	5	6
87	R:R:M124	R:R:Y98	4.79	No	Yes	1	6	6
88	R:R:L297	R:R:Y98	5.86	No	Yes	0	5	6
89	R:R:V298	R:R:Y98	3.79	No	Yes	1	5	6
90	R:R:V301	R:R:Y98	12.62	No	Yes	0	7	6
91	R:R:N101	R:R:S105	2.98	Yes	Yes	1	5	4
92	R:R:N101	R:R:R120	7.23	Yes	Yes	1	5	6
93	R:R:M124	R:R:N101	5.61	No	Yes	1	6	5
94	R:R:L104	R:R:L112	2.77	No	No	1	4	5
95	R:R:L104	R:R:Q116	3.99	No	Yes	1	4	4
96	R:R:L104	R:R:R120	4.86	No	Yes	1	4	6
97	R:R:G106	R:R:S105	3.71	No	Yes	0	4	4
98	R:R:R120	R:R:S105	6.59	Yes	Yes	1	6	4
99	R:R:K111	R:R:T108	6.01	No	No	0	1	4
100	R:R:R120	R:R:T109	5.17	Yes	No	0	6	5
101	R:R:L112	R:R:Q116	7.99	No	Yes	1	5	4
102	R:R:P114	R:R:T113	3.5	No	Yes	0	3	7
103	R:R:A115	R:R:T113	3.36	No	Yes	0	2	7
104	R:R:Q116	R:R:T113	2.83	Yes	Yes	0	4	7
105	R:R:L119	R:R:Q116	9.32	No	Yes	0	4	4
106	R:R:F118	R:R:W117	5.01	Yes	Yes	0	6	9
107	R:R:R120	R:R:W117	3	Yes	Yes	0	6	9
108	R:R:E121	R:R:W117	8.72	Yes	Yes	0	5	9
109	R:R:L197	R:R:W117	5.69	No	Yes	0	4	9
110	R:R:F118	R:R:P178	4.33	Yes	Yes	0	6	5
111	R:R:F118	R:R:I179	3.77	Yes	No	0	6	5
112	R:R:F118	R:R:N183	3.62	Yes	No	0	6	5
113	R:R:E121	R:R:L195	9.28	Yes	Yes	1	5	3
114	R:R:E121	R:R:Y198	8.98	Yes	Yes	1	5	4
115	R:R:F125	R:R:Y202	6.19	No	Yes	1	5	7
116	R:R:C206	R:R:F125	2.79	No	No	1	6	5
117	R:R:S171	R:R:V126	4.85	No	No	0	8	5
118	R:R:L128	R:R:W269	5.69	No	Yes	0	6	8
119	R:R:S129	R:R:S171	4.89	No	No	0	6	8
120	R:R:L213	R:R:V132	4.47	No	No	0	8	7
121	R:R:V132	R:R:W269	3.68	No	Yes	0	7	8
122	R:R:C167	R:R:W133	3.92	No	No	0	6	5
123	R:R:I170	R:R:W133	7.05	No	No	0	4	5
124	R:R:L213	R:R:W133	9.11	No	No	0	8	5
125	R:R:F265	R:R:L135	3.65	No	No	0	9	9
126	R:R:L135	R:R:Y311	3.52	No	Yes	0	9	9
127	R:R:I140	R:R:L136	5.71	No	No	0	6	7
128	R:R:I217	R:R:L136	5.71	No	No	0	8	7
129	R:R:A139	R:R:Y221	4	No	Yes	0	8	9
130	R:R:E141	R:R:T145	5.64	No	No	0	9	8
131	R:R:R142	R:R:Y221	8.23	No	Yes	7	9	9
132	R:R:R142	R:R:Y311	4.12	No	Yes	7	9	9
133	R:R:L220	R:R:Y143	3.52	No	No	0	7	8
134	R:R:R223	R:R:Y143	13.38	No	No	0	5	8
135	R:R:I224	R:R:Y143	3.63	No	No	0	9	8
136	R:R:K148	R:R:R231	7.43	No	No	0	6	7
137	R:R:L163	R:R:R159	3.64	No	No	0	6	5
138	R:R:F161	R:R:L160	7.31	No	No	0	2	7
139	R:R:I170	R:R:L174	2.85	No	No	0	4	5
140	R:R:F205	R:R:L174	3.65	No	No	0	5	5
141	R:R:L177	R:R:M180	2.83	No	No	0	5	4
142	R:R:P178	R:R:Y198	9.74	Yes	Yes	1	5	4
143	R:R:P178	R:R:Y202	9.74	Yes	Yes	1	5	7
144	R:R:H201	R:R:W182	8.46	No	No	0	4	5
145	R:R:I185	R:R:N183	19.82	No	No	0	3	5
146	R:R:C184	R:R:C191	7.28	No	No	3	5	9
147	R:R:H199	R:R:S190	9.76	No	No	0	4	4
148	R:R:D279	R:R:T193	5.78	Yes	No	2	4	5
149	R:R:L290	R:R:T193	10.32	Yes	No	2	3	5
150	R:R:L195	R:R:V194	4.47	Yes	No	0	3	4
151	R:R:L195	R:R:Y198	5.86	Yes	Yes	1	3	4
152	R:R:Y198	R:R:Y202	12.91	Yes	Yes	1	4	7
153	R:R:H199	R:R:H201	3.58	No	No	0	4	4
154	R:R:K200	R:R:V280	6.07	No	Yes	0	3	4
155	R:R:L204	R:R:V280	4.47	No	Yes	0	5	4
156	R:R:F273	R:R:T207	6.49	No	No	0	6	5
157	R:R:L277	R:R:T207	4.42	No	No	0	6	5
158	R:R:F210	R:R:W269	12.03	No	Yes	0	7	8
159	R:R:F210	R:R:F273	10.72	No	No	0	7	6
160	R:R:F265	R:R:L214	3.65	No	No	0	9	5
161	R:R:I266	R:R:L214	4.28	No	No	0	6	5
162	R:R:L262	R:R:V218	4.47	Yes	No	0	7	4
163	R:R:C222	R:R:I219	3.27	No	No	0	3	4
164	R:R:Y221	R:R:Y311	2.98	Yes	Yes	7	9	9
165	R:R:R229	R:R:Y225	5.14	No	No	0	5	6
166	R:R:L254	R:R:Y225	4.69	No	No	0	8	6
167	R:R:L255	R:R:Y225	17.58	No	No	0	8	6
168	R:R:R229	R:R:S226	3.95	No	No	0	5	3
169	R:R:L227	R:R:R231	7.29	No	No	0	6	7
170	R:R:R229	R:R:T230	6.47	No	No	0	5	5
171	R:R:F237	R:R:L235	6.09	No	No	0	3	6
172	R:R:L252	R:R:S251	3	No	No	0	5	7
173	R:R:T257	R:R:T314	4.71	No	No	0	9	7
174	R:R:L262	R:R:V258	2.98	Yes	No	0	7	8
175	R:R:I260	R:R:I310	4.42	No	No	0	6	8
176	R:R:L262	R:R:V261	2.98	Yes	No	0	7	8
177	R:R:T306	R:R:V264	4.76	No	No	0	5	7
178	R:R:I310	R:R:V264	4.61	No	No	0	8	7
179	R:R:F265	R:R:W269	3.01	No	Yes	0	9	8
180	R:R:C268	R:R:N303	3.15	No	Yes	0	8	9
181	R:R:N303	R:R:W269	6.78	Yes	Yes	0	9	8
182	R:R:L272	R:R:L276	2.77	No	No	0	6	6
183	R:R:F296	R:R:L275	10.96	No	No	0	4	4
184	R:R:D279	R:R:L290	6.79	Yes	Yes	2	4	3
185	R:R:C282	R:R:T286	3.38	No	No	2	4	1
186	R:R:C282	R:R:C287	7.28	No	No	2	4	3
187	R:R:C282	R:R:L290	3.17	No	Yes	2	4	3
188	R:R:K283	R:R:T286	4.5	No	No	0	1	1
189	R:R:K285	R:R:V284	7.59	No	No	0	2	1
190	R:R:C287	R:R:T286	3.38	No	No	2	3	1
191	R:R:C287	R:R:L290	7.94	No	Yes	2	3	3
192	R:R:F291	R:R:R292	5.34	No	No	0	1	4
193	R:R:N303	R:R:T306	4.39	Yes	No	0	9	5
194	R:R:N303	R:R:N307	12.26	Yes	No	0	9	9
195	R:R:L313	R:R:T312	2.95	No	No	0	6	7
196	R:R:M318	R:R:T312	7.53	No	No	0	8	7
197	R:R:F322	R:R:T312	7.78	No	No	0	7	7
198	R:R:E317	R:R:N315	5.26	No	No	0	7	8
199	R:R:M318	R:R:N315	4.21	No	No	0	8	8
200	R:R:E317	R:R:K316	20.25	No	No	0	7	6
201	R:R:K316	R:R:R319	3.71	No	No	0	6	8
202	R:R:D18	R:R:N21	2.69	No	No	0	6	8
203	R:R:C56	R:R:Y98	2.69	No	Yes	0	5	6
204	R:R:H199	R:R:K200	2.62	No	No	0	4	3
205	R:R:F291	R:R:T193	2.59	No	No	0	1	5
206	R:R:F273	R:R:T211	2.59	No	No	0	6	4
207	R:R:I289	R:R:R292	2.51	No	No	0	3	4
208	R:R:T48	R:R:Y295	2.5	No	No	0	5	3
209	R:R:F158	R:R:L162	2.44	No	No	0	4	3
210	R:R:I25	R:R:Y29	2.42	No	Yes	0	4	7
211	R:R:I84	R:R:Y311	2.42	No	Yes	0	8	9
212	R:R:I224	R:R:Y221	2.42	No	Yes	0	9	9
213	R:R:L35	R:R:Y110	2.34	No	No	0	6	5
214	R:R:L262	R:R:Y221	2.34	Yes	Yes	0	7	9
215	R:R:L93	R:R:W168	2.28	No	No	0	6	9
216	R:R:L177	R:R:W182	2.28	No	No	0	5	5
217	R:R:E294	R:R:Y295	2.24	No	No	0	3	3
218	R:R:G175	R:R:G176	2.11	No	No	0	6	4
219	R:R:G176	R:R:P178	2.03	No	Yes	0	4	5
220	R:R:G305	R:R:P308	2.03	No	Yes	0	7	9
221	R:R:A88	R:R:G85	1.95	No	No	0	9	5
222	R:R:A94	R:R:G95	1.95	No	No	0	8	7
223	R:R:W182	R:R:Y202	1.93	No	Yes	0	5	7
224	R:R:A270	R:R:P271	1.87	No	No	0	6	9
225	R:R:G281	R:R:V280	1.84	No	Yes	0	4	4
226	R:R:A127	R:R:A94	1.79	No	No	0	6	8
227	R:R:G305	R:R:I59	1.76	No	No	0	7	7
228	R:R:G33	R:R:K285	1.74	No	No	0	7	2
229	R:R:A97	R:R:S123	1.71	No	No	0	4	4
230	R:R:A187	R:R:S186	1.71	No	No	0	4	1
231	R:R:A293	R:R:V194	1.7	No	No	0	4	4
232	R:R:C57	R:R:I53	1.64	No	No	0	5	3
233	R:R:E121	R:R:G122	1.64	Yes	No	0	5	6
234	R:R:L299	R:R:P271	1.64	No	No	0	7	9
235	R:R:A139	R:R:I217	1.62	No	No	0	8	8
236	R:R:S165	R:R:V169	1.62	No	No	0	4	4
237	R:R:S263	R:R:V264	1.62	No	No	0	5	7
238	R:R:S49	R:R:T48	1.6	No	No	0	5	5
239	R:R:T99	R:R:V96	1.59	No	No	0	6	5
240	R:R:T208	R:R:V209	1.59	No	No	0	4	5
241	R:R:T257	R:R:V258	1.59	No	No	0	9	8
242	R:R:A300	R:R:L272	1.58	No	No	0	7	6
243	R:R:A293	R:R:L275	1.58	No	No	0	4	4
244	R:R:I55	R:R:V51	1.54	No	No	0	6	5
245	R:R:I173	R:R:V169	1.54	No	No	0	4	4
246	R:R:I203	R:R:V280	1.54	No	Yes	0	6	4
247	R:R:M146	R:R:V228	1.52	No	No	0	8	8
248	R:R:M146	R:R:T145	1.51	No	No	0	8	8
249	R:R:L136	R:R:S216	1.5	No	No	0	7	6
250	R:R:L35	R:R:V26	1.49	No	No	0	6	6
251	R:R:L54	R:R:V50	1.49	No	No	0	4	5
252	R:R:L172	R:R:V126	1.49	No	No	0	4	5
253	R:R:L252	R:R:V228	1.49	No	No	0	5	8
254	R:R:D279	R:R:S192	1.47	Yes	No	0	4	4
255	R:R:L302	R:R:T306	1.47	No	No	0	6	5
256	R:R:D279	R:R:V194	1.46	Yes	No	0	4	4
257	R:R:P79	R:R:R78	1.44	No	No	0	7	7
258	R:R:F83	R:R:P79	1.44	Yes	No	0	8	7
259	R:R:I53	R:R:L103	1.43	No	No	0	3	6
260	R:R:I140	R:R:L163	1.43	No	No	0	6	6
261	R:R:I259	R:R:L255	1.43	No	No	0	5	8
262	R:R:I309	R:R:L313	1.43	No	No	0	6	6
263	R:R:L227	R:R:M146	1.41	No	No	0	6	8
264	R:R:L147	R:R:M149	1.41	No	No	0	6	8
265	R:R:D288	R:R:I289	1.4	No	No	0	3	3
266	R:R:L299	R:R:L302	1.38	No	No	0	7	6
267	R:R:R233	R:R:S232	1.32	No	No	0	4	5
268	R:R:F237	R:R:S232	1.32	No	No	0	3	5
269	R:R:I323	R:R:R320	1.25	No	No	0	3	5
270	R:R:L252	R:R:R233	1.21	No	No	0	5	4
271	R:R:L160	R:R:Y82	1.17	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.77357	14	1	0
2	R:R:H28	6.09	5	3	8
3	R:R:Y29	4.385	6	4	7
4	R:R:F52	5.106	5	1	6
5	R:R:F83	3.492	5	0	8
6	R:R:L87	4.814	5	5	9
7	R:R:D91	6.106	5	5	9
8	R:R:Y98	8.14857	7	1	6
9	R:R:N101	6.2275	4	1	5
10	R:R:S105	5.805	4	1	4
11	R:R:T113	3.36	4	0	7
12	R:R:Q116	6.0325	4	1	4
13	R:R:W117	5.062	5	0	9
14	R:R:F118	4.1825	4	0	6
15	R:R:R120	5.37	5	1	6
16	R:R:E121	6.602	5	1	5
17	R:R:P178	6.46	4	1	5
18	R:R:L195	5.82	4	1	3
19	R:R:Y198	9.3725	4	1	4
20	R:R:Y202	7.6925	4	1	7
21	R:R:Y221	3.994	5	7	9
22	R:R:L262	3.1925	4	0	7
23	R:R:W269	6.238	5	0	8
24	R:R:D279	3.875	4	2	4
25	R:R:V280	3.48	4	0	4
26	R:R:L290	7.055	4	2	3
27	R:R:N303	6.645	4	0	9
28	R:R:P308	3.3975	4	0	9
29	R:R:Y311	3.26	4	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N101	14.5163	9.09	Yes	Yes	1	0	5
2	R:R:N101	R:R:R120	15.6021	7.23	Yes	Yes	1	5	6
3	R:R:L104	R:R:R120	23.686	4.86	No	Yes	1	4	6
4	R:R:L104	R:R:Q116	17.779	3.99	No	Yes	1	4	4
5	R:R:Q116	R:R:T113	11.882	2.83	Yes	Yes	0	4	7
6	L:L:?1	R:R:S105	16.0018	9.94	Yes	Yes	1	0	4
7	R:R:R120	R:R:S105	13.4982	6.59	Yes	Yes	1	6	4
8	L:L:?1	R:R:E121	41.2739	4.39	Yes	Yes	1	0	5
9	R:R:E121	R:R:W117	36.3824	8.72	Yes	Yes	0	5	9
10	R:R:L197	R:R:W117	11.1807	5.69	No	Yes	0	4	9
11	R:R:W117	R:R:Y29	20.6822	2.89	Yes	Yes	0	9	7
12	L:L:?1	R:R:M124	25.9256	6.55	Yes	No	1	0	6
13	R:R:M124	R:R:Y98	26.7074	4.79	No	Yes	1	6	6
14	R:R:F52	R:R:Y98	21.2352	6.19	Yes	Yes	1	6	6
15	L:L:?1	R:R:L297	25.9784	4.58	Yes	No	0	0	5
16	R:R:L297	R:R:Y98	24.5281	5.86	No	Yes	0	5	6
17	R:R:F52	R:R:T48	12.1836	3.89	Yes	No	0	6	5
18	R:R:C56	R:R:Y98	18.2465	2.69	No	Yes	0	5	6
19	R:R:C56	R:R:T99	15.2176	3.38	No	No	0	5	6
20	L:L:?1	R:R:L128	55.6393	6.42	Yes	No	0	0	6
21	R:R:L128	R:R:W269	55.6871	5.69	No	Yes	0	6	8
22	R:R:N303	R:R:W269	72.443	6.78	Yes	Yes	0	9	8
23	R:R:N303	R:R:N307	62.019	12.26	Yes	No	0	9	9
24	R:R:D91	R:R:N307	20.177	4.04	Yes	No	5	9	9
25	R:R:D91	R:R:N63	17.3164	12.12	Yes	No	0	9	9
26	R:R:N63	R:R:P308	12.078	4.89	No	Yes	0	9	9
27	L:L:?1	R:R:V132	57.8262	3.95	Yes	No	0	0	7
28	R:R:V132	R:R:W269	58.1605	3.68	No	Yes	0	7	8
29	L:L:?1	R:R:F210	57.1651	5.65	Yes	No	0	0	7
30	R:R:F210	R:R:W269	57.4039	12.03	No	Yes	0	7	8
31	R:R:F265	R:R:W269	100	3.01	No	Yes	0	9	8
32	R:R:F265	R:R:L135	97.4512	3.65	No	No	0	9	9
33	R:R:L135	R:R:Y311	60.7772	3.52	No	Yes	0	9	9
34	R:R:I84	R:R:Y311	22.668	2.42	No	Yes	0	8	9
35	R:R:I70	R:R:I84	21.3659	2.94	No	No	0	7	8
36	R:R:I70	R:R:M318	20.0739	2.92	No	No	0	7	8
37	R:R:L135	R:R:L87	42.7419	4.15	No	Yes	0	9	9
38	R:R:I138	R:R:L87	61.2598	2.85	No	Yes	0	8	9
39	R:R:F83	R:R:I138	58.995	3.77	Yes	No	0	8	8
40	R:R:F83	R:R:P79	17.2486	1.44	Yes	No	0	8	7
41	R:R:P79	R:R:R78	14.8958	1.44	No	No	0	7	7
42	R:R:R78	R:R:Y81	12.5456	4.12	No	No	0	7	9
43	R:R:F76	R:R:Y81	13.9356	28.88	No	No	0	8	9
44	R:R:L87	R:R:N307	40.9572	5.49	Yes	No	5	9	9
45	R:R:M318	R:R:N315	11.4672	4.21	No	No	0	8	8
46	R:R:E141	R:R:F83	30.1159	5.83	No	Yes	0	9	8
47	R:R:R142	R:R:Y311	16.5196	4.12	No	Yes	7	9	9
48	R:R:M80	R:R:R142	16.3763	4.96	No	No	0	8	9
49	R:R:E141	R:R:M80	15.3307	8.12	No	No	0	9	8
50	R:R:L87	R:R:S134	19.4832	7.51	Yes	No	0	9	8
51	R:R:N86	R:R:S134	17.0651	5.96	No	No	0	9	8
52	R:R:N86	R:R:W168	12.2138	3.39	No	No	0	9	9
53	L:L:?1	R:R:L195	31.8126	3.67	Yes	Yes	1	0	3
54	L:L:?1	R:R:F125	22.1024	17.74	Yes	No	1	0	5
55	R:R:F125	R:R:Y202	20.6897	6.19	No	Yes	1	5	7
56	R:R:Y221	R:R:Y311	22.9772	2.98	Yes	Yes	7	9	9
57	R:R:E141	R:R:T145	40.7662	5.64	No	No	0	9	8
58	R:R:M146	R:R:T145	37.4733	1.51	No	No	0	8	8
59	R:R:L227	R:R:M146	10.3336	1.41	No	No	0	6	8
60	R:R:W182	R:R:Y202	18.1082	1.93	No	Yes	0	5	7
61	R:R:H201	R:R:W182	13.2293	8.46	No	No	0	4	5
62	R:R:H199	R:R:H201	11.5929	3.58	No	No	0	4	4
63	R:R:L195	R:R:V194	27.8662	4.47	Yes	No	0	3	4
64	R:R:D279	R:R:V194	21.9566	1.46	Yes	No	0	4	4
65	R:R:D279	R:R:L290	11.0122	6.79	Yes	Yes	2	4	3
66	R:R:M146	R:R:V228	23.7187	1.52	No	No	0	8	8
67	R:R:L252	R:R:V228	20.5113	1.49	No	No	0	5	8
68	R:R:L252	R:R:R233	13.7596	1.21	No	No	0	5	4
69	R:R:R233	R:R:S232	10.5422	1.32	No	No	0	4	5
70	R:R:N303	R:R:T306	12.8698	4.39	Yes	No	0	9	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:N101	9.09	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:S105	9.94	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:E121	4.39	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M124	6.55	1	Yes	No	0	6	0	1
L:L:?1	R:R:F125	17.74	1	Yes	No	0	5	0	1
L:L:?1	R:R:L128	6.42	1	Yes	No	0	6	0	1
L:L:?1	R:R:S129	7.95	1	Yes	No	0	6	0	1
L:L:?1	R:R:V132	3.95	1	Yes	No	0	7	0	1
L:L:?1	R:R:L195	3.67	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:C206	7.36	1	Yes	No	0	6	0	1
L:L:?1	R:R:V209	2.96	1	Yes	No	0	5	0	1
L:L:?1	R:R:F210	5.65	1	Yes	No	0	7	0	1
L:L:?1	R:R:L276	4.58	1	Yes	No	0	6	0	1
L:L:?1	R:R:L297	4.58	1	Yes	No	0	5	0	1
R:R:M124	R:R:Y98	4.79	1	No	Yes	6	6	1	2
R:R:L297	R:R:Y98	5.86	0	No	Yes	5	6	1	2
R:R:N101	R:R:S105	2.98	1	Yes	Yes	5	4	1	1
R:R:N101	R:R:R120	7.23	1	Yes	Yes	5	6	1	2
R:R:M124	R:R:N101	5.61	1	No	Yes	6	5	1	1
R:R:G106	R:R:S105	3.71	0	No	Yes	4	4	2	1
R:R:R120	R:R:S105	6.59	1	Yes	Yes	6	4	2	1
R:R:R120	R:R:W117	3	1	Yes	Yes	6	9	2	2
R:R:E121	R:R:W117	8.72	1	Yes	Yes	5	9	1	2
R:R:E121	R:R:L195	9.28	1	Yes	Yes	5	3	1	1
R:R:E121	R:R:Y198	8.98	1	Yes	Yes	5	4	1	2
R:R:F125	R:R:Y202	6.19	1	No	Yes	5	7	1	2
R:R:C206	R:R:F125	2.79	1	No	No	6	5	1	1
R:R:L128	R:R:W269	5.69	0	No	Yes	6	8	1	2
R:R:S129	R:R:S171	4.89	0	No	No	6	8	1	2
R:R:L213	R:R:V132	4.47	0	No	No	8	7	2	1
R:R:V132	R:R:W269	3.68	0	No	Yes	7	8	1	2
R:R:L195	R:R:V194	4.47	1	Yes	No	3	4	1	2
R:R:L195	R:R:Y198	5.86	1	Yes	Yes	3	4	1	2
R:R:Y198	R:R:Y202	12.91	1	Yes	Yes	4	7	2	2
R:R:F210	R:R:W269	12.03	0	No	Yes	7	8	1	2
R:R:F210	R:R:F273	10.72	0	No	No	7	6	1	2
R:R:L272	R:R:L276	2.77	0	No	No	6	6	2	1
R:R:E121	R:R:G122	1.64	1	Yes	No	5	6	1	2
R:R:T208	R:R:V209	1.59	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EO4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.75
Number of Linked Nodes	256
Number of Links	271
Number of Hubs	29
Number of Links mediated by Hubs	116
Number of Communities	7
Number of Nodes involved in Communities	40
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	85259
Length Of Smallest Path	3
Average Path Length	13.1706
Length of Longest Path	25
Minimum Path Strength	1.265
Average Path Strength	5.22635
Maximum Path Strength	20.275
Minimum Path Correlation	0.7
Average Path Correlation	0.938372
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	57.0355
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.0108
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J8C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	J8C
Name	Siponimod
Synonyms	Siponimod fumarate Siponimod
Identifier
Formula	C29 H35 F3 N2 O3
Molecular Weight	516.595
SMILES
PubChem	72959169
Formal Charge	0
Total Atoms	72
Total Chiral Atoms	0
Total Bonds	75
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7EO4_nogp_Chain_R S D Y V N Y D I I V R H Y N Y T G K L N I K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V W S L L A I A I E R Y I T M L K M K N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F R S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.