psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y29	7.99	Yes	Yes	1	0	7
2	L:L:?1	R:R:K34	3.21	Yes	Yes	1	0	6
3	L:L:?1	R:R:N101	12.48	Yes	Yes	1	0	5
4	L:L:?1	R:R:S105	7.96	Yes	No	1	0	4
5	L:L:?1	R:R:T109	5.58	Yes	No	1	0	5
6	L:L:?1	R:R:R120	8.28	Yes	Yes	1	0	6
7	L:L:?1	R:R:E121	9.04	Yes	Yes	1	0	5
8	L:L:?1	R:R:M124	4.28	Yes	Yes	1	0	6
9	L:L:?1	R:R:F125	17.53	Yes	Yes	1	0	5
10	L:L:?1	R:R:L128	5.24	Yes	No	0	0	6
11	L:L:?1	R:R:S129	6.83	Yes	No	0	0	6
12	L:L:?1	R:R:L195	4.19	Yes	Yes	1	0	3
13	L:L:?1	R:R:L297	8.39	Yes	No	1	0	5
14	R:R:N183	R:R:Y19	3.49	Yes	No	0	5	8
15	R:R:D23	R:R:N21	4.04	No	No	0	7	8
16	R:R:I24	R:R:N21	7.08	No	No	0	4	8
17	R:R:T113	R:R:Y22	6.24	Yes	No	0	7	5
18	R:R:I24	R:R:R27	6.26	No	No	0	4	3
19	R:R:I25	R:R:W117	5.87	No	Yes	0	4	9
20	R:R:C184	R:R:H28	5.9	No	Yes	1	5	8
21	R:R:H28	R:R:L188	6.43	Yes	No	0	8	2
22	R:R:C191	R:R:H28	4.42	No	Yes	1	9	8
23	R:R:H28	R:R:L197	9	Yes	No	1	8	4
24	R:R:K34	R:R:Y29	9.55	Yes	Yes	1	6	7
25	R:R:T109	R:R:Y29	6.24	No	Yes	1	5	7
26	R:R:Y110	R:R:Y29	2.98	Yes	Yes	0	5	7
27	R:R:W117	R:R:Y29	6.75	Yes	Yes	1	9	7
28	R:R:P196	R:R:Y29	16.69	No	Yes	1	3	7
29	R:R:L35	R:R:N30	5.49	No	No	0	6	9
30	R:R:L188	R:R:Y31	10.55	No	No	0	2	5
31	R:R:V284	R:R:Y31	6.31	No	No	0	1	5
32	R:R:K34	R:R:T32	4.5	Yes	No	1	6	8
33	R:R:P196	R:R:T32	5.25	No	No	1	3	8
34	R:R:T32	R:R:V284	4.76	No	No	0	8	1
35	R:R:G33	R:R:K285	6.97	No	No	0	7	2
36	R:R:K34	R:R:P196	5.02	Yes	No	1	6	3
37	R:R:F291	R:R:K34	4.96	No	Yes	0	1	6
38	R:R:I37	R:R:L35	4.28	No	No	0	1	6
39	R:R:L35	R:R:Y110	4.69	No	Yes	0	6	5
40	R:R:I45	R:R:S49	9.29	No	No	0	4	5
41	R:R:K46	R:R:T48	4.5	No	No	0	4	5
42	R:R:E294	R:R:K46	8.1	No	No	0	3	4
43	R:R:F52	R:R:T48	7.78	Yes	No	0	6	5
44	R:R:I53	R:R:S49	3.1	No	No	0	3	5
45	R:R:F52	R:R:V51	3.93	Yes	No	0	6	5
46	R:R:I55	R:R:V51	3.07	No	No	0	6	5
47	R:R:F52	R:R:L102	3.65	Yes	No	0	6	5
48	R:R:F52	R:R:V298	10.49	Yes	No	0	6	5
49	R:R:C56	R:R:Y98	5.38	No	Yes	0	5	6
50	R:R:C56	R:R:T99	3.38	No	No	0	5	6
51	R:R:F58	R:R:L61	3.65	No	No	0	4	4
52	R:R:E62	R:R:F58	16.32	No	No	0	8	4
53	R:R:G305	R:R:I59	7.05	No	No	0	7	7
54	R:R:I60	R:R:L92	4.28	No	No	0	6	6
55	R:R:I60	R:R:V96	3.07	No	No	0	6	5
56	R:R:E62	R:R:P308	3.14	No	No	0	8	9
57	R:R:E62	R:R:I309	8.2	No	No	0	8	6
58	R:R:A88	R:R:N63	3.13	Yes	No	0	9	9
59	R:R:D91	R:R:N63	8.08	Yes	No	0	9	9
60	R:R:N63	R:R:P308	8.15	No	No	0	9	9
61	R:R:F322	R:R:F65	9.65	No	No	0	7	7
62	R:R:I70	R:R:V66	3.07	Yes	No	0	7	9
63	R:R:A88	R:R:V66	3.39	Yes	No	0	9	9
64	R:R:A88	R:R:L67	3.15	Yes	No	0	9	8
65	R:R:K72	R:R:L68	8.46	No	No	0	6	4
66	R:R:I70	R:R:Y81	6.04	Yes	Yes	0	7	9
67	R:R:F76	R:R:T73	16.86	Yes	No	0	8	6
68	R:R:F76	R:R:K75	4.96	Yes	No	0	8	6
69	R:R:E317	R:R:K75	8.1	No	No	0	7	6
70	R:R:F76	R:R:Y81	23.73	Yes	Yes	0	8	9
71	R:R:A321	R:R:F76	4.16	No	Yes	0	7	8
72	R:R:R78	R:R:Y81	6.17	No	Yes	0	7	9
73	R:R:P79	R:R:S155	7.13	No	No	0	7	7
74	R:R:E141	R:R:M80	4.06	No	No	0	9	8
75	R:R:N315	R:R:Y81	4.65	No	Yes	3	8	9
76	R:R:E317	R:R:Y81	3.37	No	Yes	0	7	9
77	R:R:M318	R:R:Y81	9.58	No	Yes	3	8	9
78	R:R:L160	R:R:Y82	8.21	No	No	0	7	4
79	R:R:E141	R:R:F83	15.16	No	Yes	0	9	8
80	R:R:F83	R:R:L163	6.09	Yes	No	0	8	6
81	R:R:N86	R:R:S134	5.96	No	No	0	9	8
82	R:R:I164	R:R:N86	14.16	No	No	0	7	9
83	R:R:N86	R:R:W168	6.78	No	Yes	0	9	9
84	R:R:D91	R:R:L87	8.14	Yes	Yes	2	9	9
85	R:R:L87	R:R:S134	4.5	Yes	No	0	9	8
86	R:R:L135	R:R:L87	6.92	Yes	Yes	2	9	9
87	R:R:I138	R:R:L87	4.28	No	Yes	2	8	9
88	R:R:L87	R:R:N307	6.87	Yes	Yes	2	9	9
89	R:R:L87	R:R:Y311	5.86	Yes	Yes	2	9	9
90	R:R:A130	R:R:S90	3.42	No	No	5	7	8
91	R:R:S134	R:R:S90	6.52	No	No	0	8	8
92	R:R:S90	R:R:W168	3.71	No	Yes	5	8	9
93	R:R:D91	R:R:S304	5.89	Yes	No	0	9	9
94	R:R:D91	R:R:N307	8.08	Yes	Yes	2	9	9
95	R:R:A127	R:R:L93	3.15	No	No	0	6	6
96	R:R:A94	R:R:S304	3.42	No	No	0	8	9
97	R:R:T99	R:R:V96	3.17	No	No	0	6	5
98	R:R:L102	R:R:Y98	5.86	No	Yes	0	5	6
99	R:R:M124	R:R:Y98	7.18	Yes	Yes	1	6	6
100	R:R:L297	R:R:Y98	10.55	No	Yes	1	5	6
101	R:R:V298	R:R:Y98	6.31	No	Yes	0	5	6
102	R:R:V301	R:R:Y98	13.88	No	Yes	0	7	6
103	R:R:N101	R:R:S105	2.98	Yes	No	1	5	4
104	R:R:N101	R:R:R120	4.82	Yes	Yes	1	5	6
105	R:R:E121	R:R:N101	3.94	Yes	Yes	1	5	5
106	R:R:M124	R:R:N101	5.61	Yes	Yes	1	6	5
107	R:R:G106	R:R:S105	3.71	No	No	0	4	4
108	R:R:R120	R:R:T109	6.47	Yes	No	1	6	5
109	R:R:L112	R:R:Q116	7.99	No	No	0	5	4
110	R:R:P114	R:R:T113	3.5	No	Yes	0	3	7
111	R:R:Q116	R:R:T113	12.76	No	Yes	0	4	7
112	R:R:F118	R:R:W117	5.01	Yes	Yes	1	6	9
113	R:R:R120	R:R:W117	6	Yes	Yes	1	6	9
114	R:R:E121	R:R:W117	16.36	Yes	Yes	1	5	9
115	R:R:L195	R:R:W117	3.42	Yes	Yes	1	3	9
116	R:R:L197	R:R:W117	14.81	No	Yes	1	4	9
117	R:R:W117	R:R:Y198	4.82	Yes	Yes	1	9	4
118	R:R:F118	R:R:I179	7.54	Yes	No	0	6	5
119	R:R:F118	R:R:N183	8.46	Yes	Yes	0	6	5
120	R:R:F118	R:R:L197	6.09	Yes	No	1	6	4
121	R:R:F118	R:R:Y198	4.13	Yes	Yes	1	6	4
122	R:R:E121	R:R:R120	8.14	Yes	Yes	1	5	6
123	R:R:E121	R:R:L195	6.63	Yes	Yes	1	5	3
124	R:R:E121	R:R:Y198	5.61	Yes	Yes	1	5	4
125	R:R:L297	R:R:M124	4.24	No	Yes	1	5	6
126	R:R:F125	R:R:L195	3.65	Yes	Yes	1	5	3
127	R:R:F125	R:R:Y198	10.32	Yes	Yes	1	5	4
128	R:R:F125	R:R:Y202	7.22	Yes	Yes	1	5	7
129	R:R:C206	R:R:F125	4.19	No	Yes	1	6	5
130	R:R:L128	R:R:S131	3	No	No	0	6	9
131	R:R:L128	R:R:W269	9.11	No	Yes	0	6	8
132	R:R:S129	R:R:S171	6.52	No	No	0	6	8
133	R:R:A130	R:R:W168	3.89	No	Yes	5	7	9
134	R:R:A130	R:R:S171	3.42	No	No	0	7	8
135	R:R:S131	R:R:S304	3.26	No	No	0	9	9
136	R:R:F210	R:R:V132	3.93	Yes	No	2	7	7
137	R:R:L213	R:R:V132	5.96	No	No	0	8	7
138	R:R:V132	R:R:W269	3.68	No	Yes	2	7	8
139	R:R:F133	R:R:I170	7.54	Yes	No	0	5	4
140	R:R:F133	R:R:L213	13.4	Yes	No	0	5	8
141	R:R:F265	R:R:L135	4.87	Yes	Yes	2	9	9
142	R:R:L135	R:R:N307	6.87	Yes	Yes	2	9	9
143	R:R:L135	R:R:Y311	3.52	Yes	Yes	2	9	9
144	R:R:I140	R:R:L136	7.14	No	No	0	6	7
145	R:R:I217	R:R:L136	4.28	No	No	0	8	7
146	R:R:I138	R:R:R142	6.26	No	No	2	8	9
147	R:R:I138	R:R:Y311	3.63	No	Yes	2	8	9
148	R:R:A139	R:R:L220	3.15	No	No	0	8	7
149	R:R:A139	R:R:Y221	4	No	Yes	0	8	9
150	R:R:E141	R:R:R159	10.47	No	No	0	9	5
151	R:R:R142	R:R:Y221	9.26	No	Yes	0	9	9
152	R:R:R142	R:R:Y311	6.17	No	Yes	2	9	9
153	R:R:L147	R:R:Y143	4.69	No	Yes	0	6	8
154	R:R:L220	R:R:Y143	4.69	No	Yes	0	7	8
155	R:R:R223	R:R:Y143	3.09	No	Yes	0	5	8
156	R:R:I224	R:R:Y143	3.63	No	Yes	0	9	8
157	R:R:I144	R:R:R159	7.52	No	No	0	4	5
158	R:R:N153	R:R:T145	4.39	No	No	0	4	8
159	R:R:L147	R:R:L227	6.92	No	No	0	6	6
160	R:R:M149	R:R:R231	16.13	No	No	0	8	7
161	R:R:K150	R:R:N153	8.39	No	No	0	7	4
162	R:R:H152	R:R:L151	3.86	No	No	0	7	4
163	R:R:N156	R:R:R159	16.87	No	No	0	7	5
164	R:R:L160	R:R:N157	5.49	No	No	4	7	1
165	R:R:F161	R:R:N157	4.83	No	No	4	2	1
166	R:R:F158	R:R:L162	4.87	No	No	0	4	3
167	R:R:F161	R:R:L160	9.74	No	No	4	2	7
168	R:R:I173	R:R:V169	3.07	No	No	0	4	4
169	R:R:F205	R:R:L174	3.65	No	No	0	5	5
170	R:R:C206	R:R:L174	3.17	No	No	0	6	5
171	R:R:L177	R:R:W182	4.56	No	Yes	0	5	5
172	R:R:P178	R:R:Y198	9.74	No	Yes	1	5	4
173	R:R:P178	R:R:Y202	16.69	No	Yes	1	5	7
174	R:R:G181	R:R:N183	5.09	No	Yes	0	5	5
175	R:R:H199	R:R:W182	6.35	No	Yes	0	4	5
176	R:R:W182	R:R:Y202	7.72	Yes	Yes	0	5	7
177	R:R:F205	R:R:W182	7.02	No	Yes	0	5	5
178	R:R:I185	R:R:N183	8.5	No	Yes	0	3	5
179	R:R:C184	R:R:C191	7.28	No	No	1	5	9
180	R:R:H199	R:R:S190	9.76	No	No	0	4	4
181	R:R:I203	R:R:S192	4.64	No	No	0	6	4
182	R:R:D279	R:R:S192	5.89	Yes	No	0	4	4
183	R:R:D279	R:R:T193	4.34	Yes	No	1	4	5
184	R:R:L290	R:R:T193	7.37	Yes	No	1	3	5
185	R:R:L195	R:R:V194	2.98	Yes	Yes	1	3	4
186	R:R:D279	R:R:V194	7.3	Yes	Yes	1	4	4
187	R:R:L290	R:R:V194	2.98	Yes	Yes	1	3	4
188	R:R:L195	R:R:Y198	10.55	Yes	Yes	1	3	4
189	R:R:Y198	R:R:Y202	4.96	Yes	Yes	1	4	7
190	R:R:H199	R:R:H201	9.55	No	No	0	4	4
191	R:R:C206	R:R:Y202	9.41	No	Yes	1	6	7
192	R:R:I203	R:R:V280	3.07	No	No	0	6	4
193	R:R:F273	R:R:T207	5.19	Yes	Yes	0	6	5
194	R:R:F210	R:R:F265	3.22	Yes	Yes	2	7	9
195	R:R:F210	R:R:W269	12.03	Yes	Yes	2	7	8
196	R:R:F210	R:R:F273	6.43	Yes	Yes	0	7	6
197	R:R:F273	R:R:T211	6.49	Yes	No	0	6	4
198	R:R:F265	R:R:L214	4.87	Yes	No	0	9	5
199	R:R:I266	R:R:L214	4.28	No	No	0	6	5
200	R:R:L262	R:R:V218	5.96	No	No	0	7	4
201	R:R:L262	R:R:Y221	4.69	No	Yes	0	7	9
202	R:R:R229	R:R:Y225	5.14	No	Yes	0	5	6
203	R:R:S251	R:R:Y225	3.82	No	Yes	0	7	6
204	R:R:L254	R:R:Y225	5.86	No	Yes	0	8	6
205	R:R:L255	R:R:Y225	14.07	No	Yes	0	8	6
206	R:R:L227	R:R:R231	3.64	No	No	0	6	7
207	R:R:L254	R:R:V228	4.47	No	No	0	8	8
208	R:R:R229	R:R:R233	7.46	No	No	0	5	4
209	R:R:F237	R:R:L235	4.87	No	No	0	3	6
210	R:R:K256	R:R:L252	8.46	No	No	0	7	5
211	R:R:I259	R:R:L255	4.28	No	No	0	5	8
212	R:R:T257	R:R:T314	4.71	No	No	0	9	7
213	R:R:L262	R:R:V261	2.98	No	No	0	7	8
214	R:R:T306	R:R:V264	3.17	No	No	2	5	7
215	R:R:I310	R:R:V264	4.61	Yes	No	2	8	7
216	R:R:F265	R:R:W269	6.01	Yes	Yes	2	9	8
217	R:R:F265	R:R:N303	6.04	Yes	Yes	2	9	9
218	R:R:C268	R:R:N303	6.3	No	Yes	0	8	9
219	R:R:A300	R:R:W269	7.78	No	Yes	0	7	8
220	R:R:N303	R:R:W269	9.04	Yes	Yes	2	9	8
221	R:R:F296	R:R:P271	4.33	No	No	0	4	9
222	R:R:L299	R:R:P271	3.28	No	No	0	7	9
223	R:R:L272	R:R:L276	4.15	No	No	0	6	6
224	R:R:F273	R:R:L277	7.31	Yes	No	0	6	6
225	R:R:F296	R:R:L275	17.05	No	No	0	4	4
226	R:R:C287	R:R:L278	4.76	Yes	No	1	3	4
227	R:R:L278	R:R:L290	4.15	No	Yes	1	4	3
228	R:R:D279	R:R:L290	9.5	Yes	Yes	1	4	3
229	R:R:C282	R:R:T286	3.38	No	No	1	4	1
230	R:R:C282	R:R:C287	7.28	No	Yes	1	4	3
231	R:R:K285	R:R:V284	3.04	No	No	0	2	1
232	R:R:C287	R:R:T286	3.38	Yes	No	1	3	1
233	R:R:C287	R:R:L290	3.17	Yes	Yes	1	3	3
234	R:R:N303	R:R:N307	8.17	Yes	Yes	2	9	9
235	R:R:I310	R:R:T306	3.04	Yes	No	2	8	5
236	R:R:I310	R:R:Y311	3.63	Yes	Yes	2	8	9
237	R:R:M318	R:R:T312	10.54	No	No	0	8	7
238	R:R:M318	R:R:N315	12.62	No	No	3	8	8
239	R:R:L204	R:R:T207	2.95	No	Yes	0	5	5
240	R:R:L276	R:R:T207	2.95	No	Yes	0	6	5
241	R:R:I185	R:R:I24	2.94	No	No	0	3	4
242	R:R:I55	R:R:I59	2.94	No	No	0	6	7
243	R:R:I70	R:R:I84	2.94	Yes	No	0	7	8
244	R:R:I260	R:R:I310	2.94	No	Yes	0	6	8
245	R:R:I179	R:R:M180	2.92	No	No	0	5	4
246	R:R:P79	R:R:R78	2.88	No	No	0	7	7
247	R:R:K148	R:R:K150	2.87	No	No	0	6	7
248	R:R:I45	R:R:L103	2.85	No	No	0	4	6
249	R:R:I64	R:R:L68	2.85	No	No	0	4	4
250	R:R:I64	R:R:L92	2.85	No	No	0	4	6
251	R:R:I179	R:R:L119	2.85	No	No	0	5	4
252	R:R:I140	R:R:L163	2.85	No	No	0	6	6
253	R:R:I289	R:R:L278	2.85	No	No	0	3	4
254	R:R:C167	R:R:F133	2.79	No	Yes	0	6	5
255	R:R:A137	R:R:F83	2.77	No	Yes	0	7	8
256	R:R:L275	R:R:L290	2.77	No	Yes	0	4	3
257	R:R:R229	R:R:S226	2.64	No	No	0	5	3
258	R:R:H77	R:R:K74	2.62	No	No	0	7	6
259	R:R:F133	R:R:V209	2.62	Yes	No	0	5	5
260	R:R:F205	R:R:V209	2.62	No	No	0	5	5
261	R:R:F322	R:R:T69	2.59	No	No	0	7	8
262	R:R:R234	R:R:T230	2.59	No	No	0	4	5
263	R:R:V26	R:R:Y110	2.52	No	Yes	0	6	5
264	R:R:V258	R:R:Y221	2.52	No	Yes	0	8	9
265	R:R:F83	R:R:I164	2.51	Yes	No	0	8	7
266	R:R:K316	R:R:R319	2.48	No	No	0	6	8
267	R:R:L112	R:R:R120	2.43	No	Yes	0	5	6
268	R:R:D288	R:R:F291	2.39	No	No	0	3	1
269	R:R:D288	R:R:R292	2.38	No	No	0	3	4
270	R:R:L89	R:R:W168	2.28	No	Yes	0	5	9
271	R:R:L93	R:R:W168	2.28	No	Yes	0	6	9
272	R:R:E294	R:R:Y295	2.24	No	No	0	3	3
273	R:R:H77	R:R:Y82	2.18	No	No	0	7	4
274	R:R:R231	R:R:R234	2.13	No	No	0	7	4
275	R:R:G175	R:R:G176	2.11	No	No	0	6	4
276	R:R:G176	R:R:P178	2.03	No	No	0	4	5
277	R:R:A88	R:R:G85	1.95	Yes	No	0	9	5
278	R:R:A94	R:R:G95	1.95	No	No	0	8	7
279	R:R:A270	R:R:P271	1.87	No	No	0	6	9
280	R:R:G175	R:R:V126	1.84	No	No	0	6	5
281	R:R:A127	R:R:A97	1.79	No	No	0	6	4
282	R:R:A97	R:R:S123	1.71	No	No	0	4	4
283	R:R:A187	R:R:S186	1.71	No	No	0	4	1
284	R:R:C222	R:R:V218	1.71	No	No	0	3	4
285	R:R:A293	R:R:V194	1.7	No	Yes	0	4	4
286	R:R:A115	R:R:T113	1.68	No	Yes	0	2	7
287	R:R:E121	R:R:G122	1.64	Yes	No	0	5	6
288	R:R:S49	R:R:V50	1.62	No	No	0	5	5
289	R:R:S232	R:R:V228	1.62	No	No	0	5	8
290	R:R:T257	R:R:V261	1.59	No	No	0	9	8
291	R:R:T207	R:R:T208	1.57	Yes	No	0	5	4
292	R:R:I259	R:R:S263	1.55	No	No	0	5	5
293	R:R:K250	R:R:S232	1.53	No	No	0	6	5
294	R:R:I70	R:R:T69	1.52	Yes	No	0	7	8
295	R:R:M146	R:R:V228	1.52	No	No	0	8	8
296	R:R:M146	R:R:T145	1.51	No	No	0	8	8
297	R:R:K111	R:R:T108	1.5	No	No	0	1	4
298	R:R:L136	R:R:S216	1.5	No	No	0	7	6
299	R:R:K283	R:R:T286	1.5	No	No	0	1	1
300	R:R:L172	R:R:V126	1.49	No	No	0	4	5
301	R:R:N157	R:R:S155	1.49	No	No	0	1	7
302	R:R:L254	R:R:V258	1.49	No	No	0	8	8
303	R:R:L47	R:R:T48	1.47	No	No	0	4	5
304	R:R:L112	R:R:T108	1.47	No	No	0	5	4
305	R:R:L215	R:R:T211	1.47	No	No	0	4	4
306	R:R:D18	R:R:V20	1.46	No	No	0	6	5
307	R:R:I53	R:R:L102	1.43	No	No	0	3	5
308	R:R:I55	R:R:L302	1.43	No	No	0	6	6
309	R:R:I274	R:R:L277	1.43	No	No	0	5	6
310	R:R:L103	R:R:L104	1.38	No	No	0	6	4
311	R:R:S189	R:R:Y31	1.27	No	No	0	4	5
312	R:R:I219	R:R:R223	1.25	No	No	0	4	5
313	R:R:F158	R:R:N156	1.21	No	No	0	4	7
314	R:R:L313	R:R:R319	1.21	No	No	0	6	8
315	R:R:N36	R:R:Y110	1.16	No	Yes	0	4	5
316	R:R:K72	R:R:W71	1.16	No	No	0	6	3
317	R:R:D18	R:R:Y19	1.15	No	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.76923	13	1	0
2	R:R:H28	6.4375	4	1	8
3	R:R:Y29	8.36667	6	1	7
4	R:R:K34	5.448	5	1	6
5	R:R:F52	6.4625	4	0	6
6	R:R:I70	3.3925	4	0	7
7	R:R:F76	12.4275	4	0	8
8	R:R:Y81	8.92333	6	3	9
9	R:R:F83	6.6325	4	0	8
10	R:R:L87	6.095	6	2	9
11	R:R:A88	2.905	4	0	9
12	R:R:D91	7.5475	4	2	9
13	R:R:Y98	8.19333	6	1	6
14	R:R:N101	5.966	5	1	5
15	R:R:Y110	2.8375	4	0	5
16	R:R:T113	6.045	4	0	7
17	R:R:W117	7.88	8	1	9
18	R:R:F118	6.246	5	1	6
19	R:R:R120	6.02333	6	1	6
20	R:R:E121	7.33714	7	1	5
21	R:R:M124	5.3275	4	1	6
22	R:R:F125	8.582	5	1	5
23	R:R:F133	6.5875	4	0	5
24	R:R:L135	5.545	4	2	9
25	R:R:Y143	4.025	4	0	8
26	R:R:W168	3.788	5	5	9
27	R:R:W182	6.4125	4	0	5
28	R:R:N183	6.385	4	0	5
29	R:R:V194	3.74	4	1	4
30	R:R:L195	5.23667	6	1	3
31	R:R:Y198	7.16143	7	1	4
32	R:R:Y202	9.2	5	1	7
33	R:R:T207	3.165	4	0	5
34	R:R:F210	6.4025	4	2	7
35	R:R:Y221	5.1175	4	0	9
36	R:R:Y225	7.2225	4	0	6
37	R:R:F265	5.002	5	2	9
38	R:R:W269	7.94167	6	2	8
39	R:R:F273	6.355	4	0	6
40	R:R:D279	6.7575	4	1	4
41	R:R:C287	4.6475	4	1	3
42	R:R:L290	4.99	6	1	3
43	R:R:N303	7.3875	4	2	9
44	R:R:N307	7.4975	4	2	9
45	R:R:I310	3.555	4	2	8
46	R:R:Y311	4.562	5	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E121	28.678	9.04	Yes	Yes	1	0	5
2	R:R:E121	R:R:Y198	16.627	5.61	Yes	Yes	1	5	4
3	R:R:F118	R:R:Y198	31.9441	4.13	Yes	Yes	1	6	4
4	R:R:F118	R:R:N183	53.667	8.46	Yes	Yes	0	6	5
5	L:L:?1	R:R:F125	25.3179	17.53	Yes	Yes	1	0	5
6	R:R:F125	R:R:Y198	13.6135	10.32	Yes	Yes	1	5	4
7	L:L:?1	R:R:L195	43.1139	4.19	Yes	Yes	1	0	3
8	R:R:L195	R:R:Y198	15.2466	10.55	Yes	Yes	1	3	4
9	L:L:?1	R:R:Y29	20.3043	7.99	Yes	Yes	1	0	7
10	R:R:W117	R:R:Y29	16.3216	6.75	Yes	Yes	1	9	7
11	R:R:F118	R:R:W117	43.0141	5.01	Yes	Yes	1	6	9
12	R:R:N183	R:R:Y19	16.207	3.49	Yes	No	0	5	8
13	L:L:?1	R:R:R120	21.3	8.28	Yes	Yes	1	0	6
14	R:R:R120	R:R:W117	18.4803	6	Yes	Yes	1	6	9
15	R:R:E121	R:R:W117	16.7915	16.36	Yes	Yes	1	5	9
16	R:R:L195	R:R:W117	16.3803	3.42	Yes	Yes	1	3	9
17	R:R:I185	R:R:N183	26.9892	8.5	No	Yes	0	3	5
18	R:R:I185	R:R:I24	21.6025	2.94	No	No	0	3	4
19	R:R:I24	R:R:N21	10.8115	7.08	No	No	0	4	8
20	R:R:L112	R:R:R120	10.3357	2.43	No	Yes	0	5	6
21	R:R:L197	R:R:W117	15.8898	14.81	No	Yes	1	4	9
22	R:R:H28	R:R:L197	13.5372	9	Yes	No	1	8	4
23	L:L:?1	R:R:K34	10.089	3.21	Yes	Yes	1	0	6
24	L:L:?1	R:R:M124	44.3211	4.28	Yes	Yes	1	0	6
25	R:R:M124	R:R:Y98	52.5186	7.18	Yes	Yes	1	6	6
26	R:R:L102	R:R:Y98	42.6851	5.86	No	Yes	0	5	6
27	R:R:I53	R:R:L102	14.5005	1.43	No	No	0	3	5
28	R:R:I53	R:R:S49	12.098	3.1	No	No	0	3	5
29	L:L:?1	R:R:L297	44.4092	8.39	Yes	No	1	0	5
30	R:R:L297	R:R:Y98	43.4693	10.55	No	Yes	1	5	6
31	R:R:F52	R:R:L102	26.2784	3.65	Yes	No	0	6	5
32	R:R:F52	R:R:T48	23.8611	7.78	Yes	No	0	6	5
33	R:R:K46	R:R:T48	14.292	4.5	No	No	0	4	5
34	R:R:V298	R:R:Y98	28.5311	6.31	No	Yes	0	5	6
35	R:R:F52	R:R:V298	26.1873	10.49	Yes	No	0	6	5
36	R:R:F52	R:R:V51	23.9639	3.93	Yes	No	0	6	5
37	R:R:I55	R:R:V51	19.1823	3.07	No	No	0	6	5
38	R:R:C56	R:R:Y98	21.9373	5.38	No	Yes	0	5	6
39	R:R:C56	R:R:T99	19.523	3.38	No	No	0	5	6
40	L:L:?1	R:R:L128	100	5.24	Yes	No	0	0	6
41	R:R:L128	R:R:S131	36.7051	3	No	No	0	6	9
42	R:R:S131	R:R:S304	36.1706	3.26	No	No	0	9	9
43	R:R:D91	R:R:S304	34.7255	5.89	Yes	No	0	9	9
44	R:R:D91	R:R:N63	48.7826	8.08	Yes	No	0	9	9
45	R:R:T99	R:R:V96	17.1028	3.17	No	No	0	6	5
46	R:R:I60	R:R:V96	14.6768	3.07	No	No	0	6	5
47	R:R:I60	R:R:L92	12.2448	4.28	No	No	0	6	6
48	R:R:A88	R:R:N63	40.6409	3.13	Yes	No	0	9	9
49	R:R:A88	R:R:V66	36.4907	3.39	Yes	No	0	9	9
50	R:R:I70	R:R:V66	35.0956	3.07	Yes	No	0	7	9
51	R:R:I70	R:R:Y81	28.0318	6.04	Yes	Yes	0	7	9
52	R:R:R78	R:R:Y81	13.6106	6.17	No	Yes	0	7	9
53	R:R:P79	R:R:R78	12.1215	2.88	No	No	0	7	7
54	R:R:P79	R:R:S155	10.6265	7.13	No	No	0	7	7
55	L:L:?1	R:R:S129	24.4809	6.83	Yes	No	0	0	6
56	R:R:S129	R:R:S171	23.5939	6.52	No	No	0	6	8
57	R:R:A130	R:R:S171	23.0446	3.42	No	No	0	7	8
58	R:R:A130	R:R:W168	19.7697	3.89	No	Yes	5	7	9
59	R:R:N86	R:R:W168	17.3672	6.78	No	Yes	0	9	9
60	R:R:I164	R:R:N86	21.0151	14.16	No	No	0	7	9
61	R:R:F83	R:R:I164	19.6464	2.51	Yes	No	0	8	7
62	R:R:D91	R:R:L87	16.5125	8.14	Yes	Yes	2	9	9
63	R:R:L128	R:R:W269	63.3536	9.11	No	Yes	0	6	8
64	R:R:F265	R:R:W269	46.0041	6.01	Yes	Yes	2	9	8
65	R:R:F265	R:R:L135	51.1293	4.87	Yes	Yes	2	9	9
66	R:R:I138	R:R:L87	11.4401	4.28	No	Yes	2	8	9
67	R:R:L135	R:R:Y311	43.2402	3.52	Yes	Yes	2	9	9
68	R:R:F118	R:R:I179	16.2099	7.54	Yes	No	0	6	5
69	R:R:F210	R:R:W269	11.208	12.03	Yes	Yes	2	7	8
70	R:R:R142	R:R:Y311	46.4006	6.17	No	Yes	2	9	9
71	R:R:R142	R:R:Y221	53.6905	9.26	No	Yes	0	9	9
72	R:R:A139	R:R:Y221	18.2865	4	No	Yes	0	8	9
73	R:R:A139	R:R:L220	16.7886	3.15	No	No	0	8	7
74	R:R:L220	R:R:Y143	15.2848	4.69	No	Yes	0	7	8
75	R:R:V258	R:R:Y221	27.0773	2.52	No	Yes	0	8	9
76	R:R:L254	R:R:V258	25.6058	1.49	No	No	0	8	8
77	R:R:L254	R:R:V228	12.2419	4.47	No	No	0	8	8
78	R:R:P178	R:R:Y198	12.377	9.74	No	Yes	1	5	4
79	R:R:L195	R:R:V194	21.1942	2.98	Yes	Yes	1	3	4
80	R:R:L290	R:R:V194	13.8955	2.98	Yes	Yes	1	3	4
81	R:R:F210	R:R:F273	16.1806	6.43	Yes	Yes	0	7	6
82	R:R:L254	R:R:Y225	12.3212	5.86	No	Yes	0	8	6
83	R:R:G176	R:R:P178	12.8381	2.03	No	No	0	4	5
84	R:R:D18	R:R:Y19	10.8115	1.15	No	No	0	6	8
85	R:R:N86	R:R:S134	10.647	5.96	No	No	0	9	8
86	R:R:L87	R:R:S134	15.3112	4.5	Yes	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y29	7.99	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:K34	3.21	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:N101	12.48	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:S105	7.96	1	Yes	No	0	4	0	1
L:L:?1	R:R:T109	5.58	1	Yes	No	0	5	0	1
L:L:?1	R:R:R120	8.28	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:E121	9.04	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M124	4.28	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F125	17.53	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L128	5.24	1	Yes	No	0	6	0	1
L:L:?1	R:R:S129	6.83	1	Yes	No	0	6	0	1
L:L:?1	R:R:L195	4.19	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:L297	8.39	1	Yes	No	0	5	0	1
R:R:K34	R:R:Y29	9.55	1	Yes	Yes	6	7	1	1
R:R:T109	R:R:Y29	6.24	1	No	Yes	5	7	1	1
R:R:Y110	R:R:Y29	2.98	0	Yes	Yes	5	7	2	1
R:R:W117	R:R:Y29	6.75	1	Yes	Yes	9	7	2	1
R:R:P196	R:R:Y29	16.69	1	No	Yes	3	7	2	1
R:R:K34	R:R:T32	4.5	1	Yes	No	6	8	1	2
R:R:P196	R:R:T32	5.25	1	No	No	3	8	2	2
R:R:K34	R:R:P196	5.02	1	Yes	No	6	3	1	2
R:R:F291	R:R:K34	4.96	0	No	Yes	1	6	2	1
R:R:M124	R:R:Y98	7.18	1	Yes	Yes	6	6	1	2
R:R:L297	R:R:Y98	10.55	1	No	Yes	5	6	1	2
R:R:N101	R:R:S105	2.98	1	Yes	No	5	4	1	1
R:R:N101	R:R:R120	4.82	1	Yes	Yes	5	6	1	1
R:R:E121	R:R:N101	3.94	1	Yes	Yes	5	5	1	1
R:R:M124	R:R:N101	5.61	1	Yes	Yes	6	5	1	1
R:R:G106	R:R:S105	3.71	0	No	No	4	4	2	1
R:R:R120	R:R:T109	6.47	1	Yes	No	6	5	1	1
R:R:R120	R:R:W117	6	1	Yes	Yes	6	9	1	2
R:R:E121	R:R:W117	16.36	1	Yes	Yes	5	9	1	2
R:R:L195	R:R:W117	3.42	1	Yes	Yes	3	9	1	2
R:R:W117	R:R:Y198	4.82	1	Yes	Yes	9	4	2	2
R:R:E121	R:R:R120	8.14	1	Yes	Yes	5	6	1	1
R:R:E121	R:R:L195	6.63	1	Yes	Yes	5	3	1	1
R:R:E121	R:R:Y198	5.61	1	Yes	Yes	5	4	1	2
R:R:L297	R:R:M124	4.24	1	No	Yes	5	6	1	1
R:R:F125	R:R:L195	3.65	1	Yes	Yes	5	3	1	1
R:R:F125	R:R:Y198	10.32	1	Yes	Yes	5	4	1	2
R:R:F125	R:R:Y202	7.22	1	Yes	Yes	5	7	1	2
R:R:C206	R:R:F125	4.19	1	No	Yes	6	5	2	1
R:R:L128	R:R:S131	3	0	No	No	6	9	1	2
R:R:L128	R:R:W269	9.11	0	No	Yes	6	8	1	2
R:R:S129	R:R:S171	6.52	0	No	No	6	8	1	2
R:R:L195	R:R:V194	2.98	1	Yes	Yes	3	4	1	2
R:R:L195	R:R:Y198	10.55	1	Yes	Yes	3	4	1	2
R:R:Y198	R:R:Y202	4.96	1	Yes	Yes	4	7	2	2
R:R:C206	R:R:Y202	9.41	1	No	Yes	6	7	2	2
R:R:L112	R:R:R120	2.43	0	No	Yes	5	6	2	1
R:R:E121	R:R:G122	1.64	1	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TD3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	273
Number of Links	317
Number of Hubs	46
Number of Links mediated by Hubs	172
Number of Communities	5
Number of Nodes involved in Communities	57
Number of Links involved in Communities	95

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	86954
Length Of Smallest Path	3
Average Path Length	12.4384
Length of Longest Path	29
Minimum Path Strength	1.305
Average Path Strength	5.97653
Maximum Path Strength	20.295
Minimum Path Correlation	0.7
Average Path Correlation	0.940416
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	60.603
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.8958
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • synapse • cell junction • intracellular anatomical structure • cytoplasm • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • GTPase activating protein binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • protein localization • protein localization to postsynaptic specialization membrane • cellular localization • protein localization to postsynaptic membrane • protein localization to cell periphery • protein localization to synapse • biological regulation • localization within membrane • protein localization to membrane • protein-containing complex localization • neurotransmitter receptor localization to postsynaptic specialization membrane • localization • regulation of postsynaptic membrane neurotransmitter receptor levels • protein localization to organelle • cellular macromolecule localization • macromolecule localization • cellular process • protein localization to postsynapse • regulation of biological quality • protein localization to cell junction • receptor localization to synapse • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • trans-synaptic signaling • regulation of signaling • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of biological process • cell-cell signaling • negative regulation of synaptic transmission • negative regulation of cell communication • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of cellular process • regulation of cell communication • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cell cortex • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • glutamatergic synapse • postsynapse • nucleus • intracellular membrane-bounded organelle • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • sphingolipid binding • lipid binding • bioactive lipid receptor activity • sphingosine-1-phosphate receptor activity • developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • cell adhesion • regulation of cell adhesion • lamellipodium assembly • plasma membrane bounded cell projection organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component biogenesis • cellular component assembly • lamellipodium organization • cell projection assembly • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of actin filament-based process • regulation of actin filament bundle assembly • actin filament bundle organization • actin filament-based process • stress fiber assembly • negative regulation of supramolecular fiber organization • regulation of actin filament organization • negative regulation of stress fiber assembly • actin cytoskeleton organization • actomyosin structure organization • negative regulation of cellular component organization • negative regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • negative regulation of actin filament bundle assembly • regulation of stress fiber assembly • negative regulation of organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cell population proliferation • heart trabecula morphogenesis • trabecula morphogenesis • cellular developmental process • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • homeostatic process • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • regulation of multicellular organismal process • regulation of multicellular organismal development • regulation of developmental process • bone mineralization • regulation of biomineral tissue development • regulation of bone mineralization • ossification • biomineral tissue development • regulation of ossification • chemotaxis • taxis • response to external stimulus • locomotion • positive chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of positive chemotaxis • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • regulation of positive chemotaxis • positive regulation of response to external stimulus • regulation of response to stimulus • regulation of locomotion • system process • nervous system process • transmission of nerve impulse • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • developmental growth • heart morphogenesis • organ growth • striated muscle tissue development • muscle structure development • cardiac muscle tissue growth involved in heart morphogenesis • animal organ morphogenesis • cardiac muscle tissue growth • muscle tissue development • muscle organ development • heart development • heart growth • cardiac muscle tissue development • growth • muscle tissue morphogenesis • developmental growth involved in morphogenesis • tissue morphogenesis • cardiac muscle tissue morphogenesis • growth involved in heart morphogenesis • muscle organ morphogenesis • cell chemotaxis • leukocyte chemotaxis • sphingolipid mediated signaling pathway • sphingosine-1-phosphate receptor signaling pathway • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • blood vessel maturation • developmental maturation • anatomical structure maturation • cell surface • external side of plasma membrane • membrane microdomain • membrane raft • presynapse • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • vesicle
SCOP2	Domain Identifier	• WD40 repeat-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• WD40 repeat-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	S1P
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	S1P
Name	(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
Synonyms	sphingosine 1-phosphate
Identifier
Formula	C18 H38 N O5 P
Molecular Weight	379.472
SMILES
PubChem	10883396
Formal Charge	0
Total Atoms	63
Total Chiral Atoms	2
Total Bonds	62
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7TD3_nogp_Chain_R D Y V N Y D I I V R H Y N Y T G K L N I S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K M K L H N G S N N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F R K S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	10.7554/eLife.88204
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-		2.83	2022-09-28	10.1073/pnas.2117716119
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	10.1073/pnas.2117716119
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	10.1038/s41467-022-28417-2
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	10.1038/s41467-022-28417-2
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-	Gi1/β1/γ2	2.86	2022-01-05	10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-		2.86	2022-01-05	10.1038/s41589-021-00930-3
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	10.1038/s41589-021-00930-3
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	10.1038/s41422-021-00566-x
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	10.1038/s41422-021-00566-x
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	10.1126/science.1215904
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	10.1126/science.1215904

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