psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H28	R:R:I24	6.63	Yes	No	5	8	4
2	R:R:I24	R:R:L197	9.99	No	Yes	5	4	4
3	R:R:I25	R:R:P114	5.08	No	No	0	4	3
4	R:R:H28	R:R:R27	5.64	Yes	No	0	8	3
5	R:R:H28	R:R:L188	3.86	Yes	No	0	8	2
6	R:R:C191	R:R:H28	4.42	No	Yes	0	9	8
7	R:R:H28	R:R:L197	7.71	Yes	Yes	5	8	4
8	R:R:K34	R:R:Y29	3.58	No	Yes	1	6	7
9	R:R:L35	R:R:Y29	5.86	Yes	Yes	0	6	7
10	R:R:P196	R:R:Y29	12.52	No	Yes	0	3	7
11	L:L:?1	R:R:Y29	7.11	Yes	Yes	1	0	7
12	R:R:L35	R:R:N30	8.24	Yes	No	0	6	9
13	R:R:L188	R:R:Y31	7.03	No	No	0	2	5
14	R:R:V284	R:R:Y31	15.14	No	No	0	1	5
15	R:R:P196	R:R:T32	3.5	No	No	0	3	8
16	R:R:F291	R:R:T32	3.89	No	No	0	1	8
17	R:R:G33	R:R:K285	5.23	No	No	0	7	2
18	R:R:F291	R:R:K34	9.93	No	No	0	1	6
19	L:L:?1	R:R:K34	7.48	Yes	No	1	0	6
20	R:R:L35	R:R:N36	6.87	Yes	No	0	6	4
21	R:R:L35	R:R:Y110	3.52	Yes	Yes	0	6	5
22	R:R:K46	R:R:S49	3.06	No	No	0	4	5
23	R:R:F52	R:R:T48	5.19	No	No	0	6	5
24	R:R:T48	R:R:Y295	4.99	No	No	0	5	3
25	R:R:L54	R:R:V50	2.98	No	No	0	4	5
26	R:R:F52	R:R:V298	17.04	No	No	0	6	5
27	R:R:I53	R:R:T99	3.04	Yes	No	0	3	6
28	R:R:I53	R:R:L102	7.14	Yes	No	0	3	5
29	R:R:C56	R:R:T99	5.07	No	No	0	5	6
30	R:R:I59	R:R:S304	3.1	No	No	0	7	9
31	R:R:G305	R:R:I59	3.53	No	No	0	7	7
32	R:R:I60	R:R:V96	3.07	No	No	0	6	5
33	R:R:F65	R:R:L61	12.18	No	No	0	7	4
34	R:R:E62	R:R:F65	3.5	No	No	0	8	7
35	R:R:E62	R:R:P308	4.72	No	No	0	8	9
36	R:R:A88	R:R:N63	3.13	No	No	0	9	9
37	R:R:D91	R:R:N63	4.04	Yes	No	0	9	9
38	R:R:N63	R:R:P308	8.15	No	No	0	9	9
39	R:R:F322	R:R:F65	5.36	No	No	0	7	7
40	R:R:F322	R:R:T69	3.89	No	No	0	7	8
41	R:R:F76	R:R:T73	11.67	Yes	Yes	0	8	6
42	R:R:F76	R:R:Y81	36.1	Yes	No	2	8	9
43	R:R:E317	R:R:F76	4.66	Yes	Yes	2	7	8
44	R:R:F76	R:R:M318	3.73	Yes	Yes	2	8	8
45	R:R:H77	R:R:Y82	7.62	No	No	0	7	4
46	R:R:E141	R:R:M80	6.77	Yes	No	7	9	8
47	R:R:M80	R:R:T145	4.52	No	No	7	8	8
48	R:R:M318	R:R:Y81	3.59	Yes	No	2	8	9
49	R:R:F83	R:R:I138	5.02	Yes	No	0	8	8
50	R:R:E141	R:R:F83	11.66	Yes	Yes	0	9	8
51	R:R:F83	R:R:L160	3.65	Yes	No	0	8	7
52	R:R:I84	R:R:Y311	4.84	No	Yes	0	8	9
53	R:R:N86	R:R:S134	4.47	No	No	0	9	8
54	R:R:N86	R:R:W168	7.91	No	Yes	0	9	9
55	R:R:L87	R:R:S134	3	No	No	0	9	8
56	R:R:L135	R:R:L87	5.54	No	No	0	9	9
57	R:R:L87	R:R:N307	9.61	No	No	0	9	9
58	R:R:A130	R:R:S90	3.42	No	No	8	7	8
59	R:R:S131	R:R:S90	3.26	No	No	0	9	8
60	R:R:S90	R:R:W168	3.71	No	Yes	8	8	9
61	R:R:D91	R:R:S131	5.89	Yes	No	0	9	9
62	R:R:D91	R:R:S304	11.78	Yes	No	0	9	9
63	R:R:D91	R:R:N307	6.73	Yes	No	0	9	9
64	R:R:L102	R:R:Y98	11.72	No	Yes	0	5	6
65	R:R:L297	R:R:Y98	5.86	Yes	Yes	0	5	6
66	R:R:V298	R:R:Y98	3.79	No	Yes	0	5	6
67	R:R:V301	R:R:Y98	3.79	No	Yes	0	7	6
68	R:R:N101	R:R:R120	4.82	No	Yes	1	5	6
69	L:L:?1	R:R:N101	9.36	Yes	No	1	0	5
70	R:R:L104	R:R:Q116	5.32	No	No	0	4	4
71	R:R:L104	R:R:R120	4.86	No	Yes	0	4	6
72	R:R:A107	R:R:Y110	4	No	Yes	1	4	5
73	R:R:A107	R:R:K111	3.21	No	No	1	4	1
74	R:R:K111	R:R:T108	3	No	No	0	1	4
75	R:R:L112	R:R:T108	7.37	No	No	0	5	4
76	R:R:T109	R:R:Y110	3.75	No	Yes	1	5	5
77	R:R:R120	R:R:T109	3.88	Yes	No	1	6	5
78	L:L:?1	R:R:T109	5.58	Yes	No	1	0	5
79	R:R:K111	R:R:Y110	4.78	No	Yes	1	1	5
80	R:R:P114	R:R:T113	3.5	No	No	0	3	7
81	R:R:F118	R:R:W117	7.02	No	Yes	0	6	9
82	R:R:R120	R:R:W117	5	Yes	Yes	0	6	9
83	R:R:E121	R:R:W117	11.99	Yes	Yes	0	5	9
84	R:R:L197	R:R:W117	4.56	Yes	Yes	0	4	9
85	R:R:F118	R:R:I179	7.54	No	No	0	6	5
86	L:L:?1	R:R:R120	9.2	Yes	Yes	1	0	6
87	R:R:E121	R:R:L195	7.95	Yes	No	1	5	3
88	R:R:E121	R:R:Y198	6.73	Yes	No	0	5	4
89	L:L:?1	R:R:E121	9.04	Yes	Yes	1	0	5
90	R:R:M124	R:R:S123	3.07	No	No	0	6	4
91	L:L:?1	R:R:M124	4.28	Yes	No	0	0	6
92	R:R:F125	R:R:S129	3.96	Yes	No	0	5	6
93	R:R:F125	R:R:L174	3.65	Yes	Yes	1	5	5
94	R:R:F125	R:R:G175	3.01	Yes	No	0	5	6
95	R:R:F125	R:R:Y202	11.35	Yes	Yes	1	5	7
96	R:R:C206	R:R:F125	4.19	No	Yes	0	6	5
97	L:L:?1	R:R:F125	12.92	Yes	Yes	1	0	5
98	R:R:L128	R:R:W269	3.42	No	Yes	0	6	8
99	R:R:S129	R:R:S171	3.26	No	No	0	6	8
100	R:R:A130	R:R:W168	3.89	No	Yes	8	7	9
101	R:R:A130	R:R:S171	3.42	No	No	0	7	8
102	R:R:L213	R:R:V132	4.47	No	No	0	8	7
103	R:R:V132	R:R:W269	3.68	No	Yes	0	7	8
104	R:R:C167	R:R:W133	3.92	No	No	0	6	5
105	R:R:L213	R:R:W133	9.11	No	No	0	8	5
106	R:R:L135	R:R:Y311	3.52	No	Yes	0	9	9
107	R:R:L136	R:R:L213	5.54	Yes	No	0	7	8
108	R:R:L136	R:R:S216	3	Yes	No	0	7	6
109	R:R:I217	R:R:L136	5.71	No	Yes	0	8	7
110	R:R:I138	R:R:Y311	4.84	No	Yes	0	8	9
111	R:R:A139	R:R:Y221	5.34	No	Yes	0	8	9
112	R:R:E141	R:R:T145	4.23	Yes	No	7	9	8
113	R:R:E141	R:R:R159	10.47	Yes	No	0	9	5
114	R:R:R142	R:R:Y221	8.23	No	Yes	3	9	9
115	R:R:R142	R:R:Y311	8.23	No	Yes	3	9	9
116	R:R:L147	R:R:Y143	5.86	No	Yes	0	6	8
117	R:R:R223	R:R:Y143	18.52	No	Yes	0	5	8
118	R:R:I224	R:R:Y143	8.46	No	Yes	0	9	8
119	R:R:L227	R:R:M146	4.24	No	No	0	6	8
120	R:R:L147	R:R:M149	4.24	No	No	0	6	8
121	R:R:K148	R:R:R231	7.43	No	No	0	6	7
122	R:R:F161	R:R:L160	6.09	No	No	0	2	7
123	R:R:F161	R:R:I164	5.02	No	No	0	2	7
124	R:R:I173	R:R:V169	3.07	No	No	0	4	4
125	R:R:L174	R:R:Y202	5.86	Yes	Yes	1	5	7
126	R:R:F205	R:R:L174	3.65	No	Yes	1	5	5
127	R:R:P178	R:R:Y202	5.56	No	Yes	0	5	7
128	R:R:H201	R:R:W182	19.04	No	No	0	4	5
129	R:R:C184	R:R:C191	7.28	No	No	0	5	9
130	R:R:S189	R:R:S190	3.26	No	No	0	4	4
131	R:R:H199	R:R:S190	12.55	Yes	No	0	4	4
132	R:R:K200	R:R:S192	4.59	No	No	0	3	4
133	R:R:D279	R:R:S192	5.89	No	No	0	4	4
134	R:R:D279	R:R:T193	5.78	No	No	0	4	5
135	R:R:F291	R:R:T193	3.89	No	No	0	1	5
136	R:R:D279	R:R:V194	5.84	No	No	0	4	4
137	L:L:?1	R:R:L195	3.15	Yes	No	1	0	3
138	R:R:Y198	R:R:Y202	9.93	No	Yes	0	4	7
139	R:R:I203	R:R:Y198	9.67	No	No	0	6	4
140	R:R:H199	R:R:H201	13.14	Yes	No	0	4	4
141	R:R:K200	R:R:V280	6.07	No	No	0	3	4
142	R:R:F205	R:R:Y202	5.16	No	Yes	1	5	7
143	R:R:I203	R:R:L276	5.71	No	No	0	6	6
144	R:R:F205	R:R:V209	3.93	No	No	0	5	5
145	R:R:C206	R:R:F210	4.19	No	No	0	6	7
146	R:R:F273	R:R:T207	3.89	No	No	0	6	5
147	R:R:F210	R:R:V209	3.93	No	No	0	7	5
148	R:R:F210	R:R:W269	8.02	No	Yes	0	7	8
149	R:R:F273	R:R:T211	3.89	No	No	0	6	4
150	R:R:I266	R:R:L214	4.28	No	No	0	6	5
151	R:R:I219	R:R:V218	3.07	No	No	0	4	4
152	R:R:L262	R:R:V218	4.47	No	No	0	7	4
153	R:R:V258	R:R:Y221	5.05	No	Yes	0	8	9
154	R:R:Y221	R:R:Y311	3.97	Yes	Yes	3	9	9
155	R:R:R229	R:R:Y225	10.29	No	No	0	5	6
156	R:R:L254	R:R:Y225	8.21	Yes	No	0	8	6
157	R:R:L255	R:R:Y225	10.55	No	No	0	8	6
158	R:R:L254	R:R:V228	4.47	Yes	No	0	8	8
159	R:R:R229	R:R:R233	5.33	No	No	0	5	4
160	R:R:A253	R:R:K256	3.21	No	No	0	7	7
161	R:R:L254	R:R:V258	2.98	Yes	No	0	8	8
162	R:R:T257	R:R:T314	4.71	No	No	0	9	7
163	R:R:I259	R:R:I260	4.42	No	No	0	5	6
164	R:R:I310	R:R:V261	3.07	No	No	3	8	8
165	R:R:V261	R:R:Y311	3.79	No	Yes	3	8	9
166	R:R:T306	R:R:V264	4.76	No	No	0	5	7
167	R:R:F265	R:R:W269	8.02	No	Yes	0	9	8
168	R:R:C268	R:R:N303	7.87	No	No	0	8	9
169	R:R:L299	R:R:P271	3.28	No	No	0	7	9
170	R:R:F296	R:R:L275	12.18	No	No	0	4	4
171	R:R:C287	R:R:L278	3.17	Yes	No	4	3	4
172	R:R:L278	R:R:L290	4.15	No	Yes	4	4	3
173	R:R:K283	R:R:T286	19.52	No	No	0	1	1
174	R:R:C287	R:R:L290	7.94	Yes	Yes	4	3	3
175	R:R:E294	R:R:R292	9.3	No	No	6	3	4
176	R:R:R292	R:R:Y295	5.14	No	No	6	4	3
177	R:R:E294	R:R:Y295	5.61	No	No	6	3	3
178	L:L:?1	R:R:L297	6.29	Yes	Yes	1	0	5
179	R:R:I310	R:R:Y311	4.84	No	Yes	3	8	9
180	R:R:L313	R:R:T312	4.42	No	No	0	6	7
181	R:R:M318	R:R:T312	10.54	Yes	No	0	8	7
182	R:R:E317	R:R:N315	3.94	Yes	No	0	7	8
183	R:R:M318	R:R:N315	8.41	Yes	No	0	8	8
184	R:R:E317	R:R:K316	4.05	Yes	No	2	7	6
185	R:R:K316	R:R:R320	14.85	No	No	2	6	5
186	R:R:E317	R:R:R320	6.98	Yes	No	2	7	5
187	R:R:C184	R:R:H199	2.95	No	Yes	0	5	4
188	R:R:L290	R:R:T193	2.95	Yes	No	0	3	5
189	R:R:L204	R:R:T207	2.95	No	No	0	5	5
190	R:R:I140	R:R:I144	2.94	No	No	0	6	4
191	R:R:I260	R:R:I310	2.94	No	No	0	6	8
192	R:R:A187	R:R:H199	2.93	No	Yes	0	4	4
193	R:R:I70	R:R:M318	2.92	No	Yes	0	7	8
194	R:R:I224	R:R:M146	2.92	No	No	0	9	8
195	R:R:P79	R:R:R78	2.88	No	No	0	7	7
196	R:R:K150	R:R:M149	2.88	No	No	0	7	8
197	R:R:I25	R:R:L197	2.85	No	Yes	0	4	4
198	R:R:I53	R:R:L103	2.85	Yes	No	0	3	6
199	R:R:I64	R:R:L61	2.85	No	No	0	4	4
200	R:R:I70	R:R:L67	2.85	No	No	0	7	8
201	R:R:I140	R:R:L136	2.85	No	Yes	0	6	7
202	R:R:I309	R:R:L313	2.85	No	No	0	6	6
203	R:R:K148	R:R:L151	2.82	No	No	0	6	4
204	R:R:A137	R:R:F83	2.77	No	Yes	0	7	8
205	R:R:L252	R:R:L254	2.77	No	Yes	0	5	8
206	R:R:L272	R:R:L297	2.77	No	Yes	1	6	5
207	R:R:L275	R:R:L278	2.77	No	No	4	4	4
208	R:R:L275	R:R:L290	2.77	No	Yes	4	4	3
209	R:R:F52	R:R:I55	2.51	No	No	0	6	6
210	R:R:F83	R:R:L163	2.44	Yes	No	0	8	6
211	R:R:F265	R:R:L214	2.44	No	No	0	9	5
212	R:R:L235	R:R:R234	2.43	No	No	0	6	4
213	R:R:F265	R:R:N303	2.42	No	No	0	9	9
214	R:R:L220	R:R:Y143	2.34	No	Yes	0	7	8
215	R:R:K72	R:R:W71	2.32	No	No	0	6	3
216	R:R:L93	R:R:W168	2.28	No	Yes	0	6	9
217	R:R:F76	R:R:R78	2.14	Yes	No	0	8	7
218	R:R:G175	R:R:G176	2.11	No	No	0	6	4
219	R:R:F273	R:R:W269	2	No	Yes	0	6	8
220	R:R:A88	R:R:G85	1.95	No	No	0	9	5
221	R:R:A94	R:R:G95	1.95	No	No	0	8	7
222	R:R:A270	R:R:P271	1.87	No	No	0	6	9
223	R:R:G106	R:R:S105	1.86	No	No	0	4	4
224	R:R:G95	R:R:V301	1.84	No	No	0	7	7
225	R:R:G33	R:R:T32	1.82	No	No	0	7	8
226	R:R:A127	R:R:A94	1.79	No	No	0	6	8
227	R:R:P308	R:R:V66	1.77	No	No	0	9	9
228	R:R:G85	R:R:I70	1.76	No	No	0	5	7
229	R:R:G106	R:R:K46	1.74	No	No	0	4	4
230	R:R:A97	R:R:S123	1.71	No	No	0	4	4
231	R:R:C268	R:R:V264	1.71	No	No	0	8	7
232	R:R:C287	R:R:T286	1.69	Yes	No	0	3	1
233	R:R:A321	R:R:T69	1.68	No	No	0	7	8
234	R:R:A321	R:R:T73	1.68	No	Yes	0	7	6
235	R:R:A115	R:R:T113	1.68	No	No	0	2	7
236	R:R:C57	R:R:I53	1.64	No	Yes	0	5	3
237	R:R:E121	R:R:G122	1.64	Yes	No	0	5	6
238	R:R:L177	R:R:P178	1.64	No	No	0	5	5
239	R:R:C222	R:R:I219	1.64	No	No	0	3	4
240	R:R:C287	R:R:I289	1.64	Yes	No	0	3	3
241	R:R:S171	R:R:V126	1.62	No	No	0	8	5
242	R:R:A270	R:R:I274	1.62	No	No	0	6	5
243	R:R:S226	R:R:T230	1.6	No	No	0	3	5
244	R:R:T257	R:R:V261	1.59	No	No	0	9	8
245	R:R:A139	R:R:L220	1.58	No	No	0	8	7
246	R:R:A300	R:R:L272	1.58	No	No	1	7	6
247	R:R:A300	R:R:L297	1.58	No	Yes	1	7	5
248	R:R:T207	R:R:T208	1.57	No	No	0	5	4
249	R:R:I164	R:R:S165	1.55	No	No	0	7	4
250	R:R:I55	R:R:V51	1.54	No	No	0	6	5
251	R:R:I60	R:R:T99	1.52	No	No	0	6	6
252	R:R:L102	R:R:S49	1.5	No	No	0	5	5
253	R:R:K72	R:R:T73	1.5	No	Yes	0	6	6
254	R:R:K75	R:R:T73	1.5	No	Yes	0	6	6
255	R:R:L212	R:R:S216	1.5	No	No	0	5	6
256	R:R:L35	R:R:V26	1.49	Yes	No	0	6	6
257	R:R:L92	R:R:V96	1.49	No	No	0	6	5
258	R:R:L172	R:R:V126	1.49	No	No	0	4	5
259	R:R:L215	R:R:V218	1.49	No	No	0	4	4
260	R:R:I55	R:R:L302	1.43	No	No	0	6	6
261	R:R:I59	R:R:L302	1.43	No	No	0	7	6
262	R:R:I170	R:R:L174	1.43	No	Yes	0	4	5
263	R:R:I217	R:R:L262	1.43	No	No	0	8	7
264	R:R:L151	R:R:M146	1.41	No	No	0	4	8
265	R:R:K148	R:R:L227	1.41	No	No	0	6	6
266	R:R:L177	R:R:M180	1.41	No	No	0	5	4
267	R:R:K256	R:R:L255	1.41	No	No	0	7	8
268	R:R:D288	R:R:I289	1.4	No	No	0	3	3
269	R:R:L89	R:R:L92	1.38	No	No	0	5	6
270	R:R:L89	R:R:L93	1.38	No	No	0	5	6
271	R:R:L299	R:R:L302	1.38	No	No	0	7	6
272	R:R:L119	R:R:Q116	1.33	No	No	0	4	4
273	R:R:H77	R:R:K74	1.31	No	No	0	7	6
274	R:R:R233	R:R:T236	1.29	No	No	0	4	4
275	R:R:I323	R:R:R324	1.25	No	No	0	3	4
276	R:R:K316	R:R:R319	1.24	No	No	0	6	8
277	R:R:D23	R:R:R27	1.19	No	No	0	7	3
278	R:R:F158	R:R:R159	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H28	5.652	5	5	8
2	R:R:Y29	7.2675	4	1	7
3	R:R:L35	5.196	5	0	6
4	R:R:I53	3.6675	4	0	3
5	R:R:T73	4.0875	4	0	6
6	R:R:F76	11.66	5	2	8
7	R:R:F83	5.108	5	0	8
8	R:R:D91	7.11	4	0	9
9	R:R:Y98	6.29	4	0	6
10	R:R:Y110	4.0125	4	1	5
11	R:R:W117	7.1425	4	0	9
12	R:R:R120	5.552	5	1	6
13	R:R:E121	7.47	5	1	5
14	R:R:F125	6.51333	6	1	5
15	R:R:L136	4.275	4	0	7
16	R:R:E141	8.2825	4	7	9
17	R:R:Y143	8.795	4	0	8
18	R:R:W168	4.4475	4	8	9
19	R:R:L174	3.6475	4	1	5
20	R:R:L197	6.2775	4	5	4
21	R:R:H199	7.8925	4	0	4
22	R:R:Y202	7.572	5	1	7
23	R:R:Y221	5.6475	4	3	9
24	R:R:L254	4.6075	4	0	8
25	R:R:W269	5.028	5	0	8
26	R:R:C287	3.61	4	4	3
27	R:R:L290	4.4525	4	4	3
28	R:R:L297	4.125	4	1	5
29	R:R:Y311	4.86143	7	3	9
30	R:R:E317	4.9075	4	2	7
31	R:R:M318	5.838	5	2	8
32	L:L:?1	7.441	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H28	R:R:L197	41.8079	7.71	Yes	Yes	5	8	4
2	R:R:I25	R:R:L197	12.2305	2.85	No	Yes	0	4	4
3	R:R:L197	R:R:W117	58.8317	4.56	Yes	Yes	0	4	9
4	R:R:R120	R:R:W117	33.8234	5	Yes	Yes	0	6	9
5	L:L:?1	R:R:R120	37.153	9.2	Yes	Yes	1	0	6
6	L:L:?1	R:R:K34	32.7158	7.48	Yes	No	1	0	6
7	R:R:E121	R:R:W117	33.5201	11.99	Yes	Yes	0	5	9
8	L:L:?1	R:R:E121	35.5706	9.04	Yes	Yes	1	0	5
9	L:L:?1	R:R:Y29	14.4788	7.11	Yes	Yes	1	0	7
10	R:R:F291	R:R:K34	32.3268	9.93	No	No	0	1	6
11	L:L:?1	R:R:L297	36.619	6.29	Yes	Yes	1	0	5
12	R:R:L297	R:R:Y98	33.3817	5.86	Yes	Yes	0	5	6
13	R:R:L102	R:R:Y98	17.8611	11.72	No	Yes	0	5	6
14	R:R:F52	R:R:V298	23.7819	17.04	No	No	0	6	5
15	R:R:V298	R:R:Y98	24.2236	3.79	No	Yes	0	5	6
16	R:R:F52	R:R:I55	21.7248	2.51	No	No	0	6	6
17	R:R:I55	R:R:L302	20.8809	1.43	No	No	0	6	6
18	R:R:I59	R:R:L302	18.738	1.43	No	No	0	7	6
19	L:L:?1	R:R:F125	100	12.92	Yes	Yes	1	0	5
20	R:R:F125	R:R:S129	98.0418	3.96	Yes	No	0	5	6
21	R:R:S129	R:R:S171	97.6264	3.26	No	No	0	6	8
22	R:R:A130	R:R:S171	96.499	3.42	No	No	0	7	8
23	R:R:A130	R:R:S90	40.1991	3.42	No	No	8	7	8
24	R:R:S131	R:R:S90	42.5529	3.26	No	No	0	9	8
25	R:R:D91	R:R:S131	42.1705	5.89	Yes	No	0	9	9
26	R:R:D91	R:R:S304	19.2062	11.78	Yes	No	0	9	9
27	R:R:I59	R:R:S304	18.4216	3.1	No	No	0	7	9
28	R:R:E62	R:R:F65	10.0284	3.5	No	No	0	8	7
29	R:R:E62	R:R:P308	11.6239	4.72	No	No	0	8	9
30	R:R:N63	R:R:P308	15.026	8.15	No	No	0	9	9
31	R:R:D91	R:R:N63	56.7416	4.04	Yes	No	0	9	9
32	R:R:A88	R:R:N63	41.1881	3.13	No	No	0	9	9
33	R:R:F76	R:R:M318	18.9358	3.73	Yes	Yes	2	8	8
34	R:R:I70	R:R:M318	35.0696	2.92	No	Yes	0	7	8
35	R:R:G85	R:R:I70	38.142	1.76	No	No	0	5	7
36	R:R:A88	R:R:G85	39.6651	1.95	No	No	0	9	5
37	R:R:F83	R:R:I138	20.8413	5.02	Yes	No	0	8	8
38	R:R:I138	R:R:Y311	22.4698	4.84	No	Yes	0	8	9
39	R:R:L135	R:R:Y311	73.3566	3.52	No	Yes	0	9	9
40	R:R:L135	R:R:L87	74.5896	5.54	No	No	0	9	9
41	R:R:L87	R:R:S134	54.8691	3	No	No	0	9	8
42	R:R:N86	R:R:S134	55.3504	4.47	No	No	0	9	8
43	R:R:N86	R:R:W168	56.1746	7.91	No	Yes	0	9	9
44	R:R:A130	R:R:W168	55.9702	3.89	No	Yes	8	7	9
45	R:R:D91	R:R:N307	23.4852	6.73	Yes	No	0	9	9
46	R:R:C206	R:R:F125	51.2099	4.19	No	Yes	0	6	5
47	R:R:C206	R:R:F210	49.7923	4.19	No	No	0	6	7
48	R:R:F210	R:R:W269	49.2055	8.02	No	Yes	0	7	8
49	R:R:V132	R:R:W269	26.7752	3.68	No	Yes	0	7	8
50	R:R:L213	R:R:V132	25.0742	4.47	No	No	0	8	7
51	R:R:L136	R:R:L213	19.8919	5.54	Yes	No	0	7	8
52	R:R:I217	R:R:L136	11.1096	5.71	No	Yes	0	8	7
53	R:R:A139	R:R:Y221	25.9445	5.34	No	Yes	0	8	9
54	R:R:Y221	R:R:Y311	44.2144	3.97	Yes	Yes	3	9	9
55	R:R:A139	R:R:L220	24.2962	1.58	No	No	0	8	7
56	R:R:L220	R:R:Y143	22.6347	2.34	No	Yes	0	7	8
57	R:R:I224	R:R:Y143	14.1294	8.46	No	Yes	0	9	8
58	R:R:I224	R:R:M146	12.3756	2.92	No	No	0	9	8
59	R:R:C184	R:R:H199	18.2699	2.95	No	Yes	0	5	4
60	R:R:C184	R:R:C191	21.2699	7.28	No	No	0	5	9
61	R:R:C191	R:R:H28	24.2566	4.42	No	Yes	0	9	8
62	R:R:F291	R:R:T193	26.3994	3.89	No	No	0	1	5
63	R:R:F265	R:R:W269	12.9162	8.02	No	Yes	0	9	8
64	R:R:V258	R:R:Y221	19.226	5.05	No	Yes	0	8	9
65	R:R:L254	R:R:V258	17.7029	2.98	Yes	No	0	8	8
66	R:R:L254	R:R:Y225	12.5272	8.21	Yes	No	0	8	6
67	R:R:L290	R:R:T193	16.1931	2.95	Yes	No	0	3	5
68	R:R:F125	R:R:Y202	10.7272	11.35	Yes	Yes	1	5	7
69	R:R:L87	R:R:N307	22.3907	9.61	No	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K34	R:R:Y29	3.58	1	No	Yes	6	7	1	1
R:R:L35	R:R:Y29	5.86	0	Yes	Yes	6	7	2	1
R:R:P196	R:R:Y29	12.52	0	No	Yes	3	7	2	1
L:L:?1	R:R:Y29	7.11	1	Yes	Yes	0	7	0	1
R:R:F291	R:R:K34	9.93	0	No	No	1	6	2	1
L:L:?1	R:R:K34	7.48	1	Yes	No	0	6	0	1
R:R:L35	R:R:Y110	3.52	0	Yes	Yes	6	5	2	2
R:R:L297	R:R:Y98	5.86	1	Yes	Yes	5	6	1	2
R:R:N101	R:R:R120	4.82	1	No	Yes	5	6	1	1
L:L:?1	R:R:N101	9.36	1	Yes	No	0	5	0	1
R:R:L104	R:R:R120	4.86	0	No	Yes	4	6	2	1
R:R:T109	R:R:Y110	3.75	1	No	Yes	5	5	1	2
R:R:R120	R:R:T109	3.88	1	Yes	No	6	5	1	1
L:L:?1	R:R:T109	5.58	1	Yes	No	0	5	0	1
R:R:R120	R:R:W117	5	1	Yes	Yes	6	9	1	2
R:R:E121	R:R:W117	11.99	1	Yes	Yes	5	9	1	2
L:L:?1	R:R:R120	9.2	1	Yes	Yes	0	6	0	1
R:R:E121	R:R:L195	7.95	1	Yes	No	5	3	1	1
R:R:E121	R:R:Y198	6.73	1	Yes	No	5	4	1	2
L:L:?1	R:R:E121	9.04	1	Yes	Yes	0	5	0	1
R:R:M124	R:R:S123	3.07	0	No	No	6	4	1	2
L:L:?1	R:R:M124	4.28	1	Yes	No	0	6	0	1
R:R:F125	R:R:S129	3.96	1	Yes	No	5	6	1	2
R:R:F125	R:R:L174	3.65	1	Yes	Yes	5	5	1	2
R:R:F125	R:R:G175	3.01	1	Yes	No	5	6	1	2
R:R:F125	R:R:Y202	11.35	1	Yes	Yes	5	7	1	2
R:R:C206	R:R:F125	4.19	0	No	Yes	6	5	2	1
L:L:?1	R:R:F125	12.92	1	Yes	Yes	0	5	0	1
R:R:L174	R:R:Y202	5.86	1	Yes	Yes	5	7	2	2
L:L:?1	R:R:L195	3.15	1	Yes	No	0	3	0	1
R:R:Y198	R:R:Y202	9.93	0	No	Yes	4	7	2	2
L:L:?1	R:R:L297	6.29	1	Yes	Yes	0	5	0	1
R:R:L272	R:R:L297	2.77	1	No	Yes	6	5	2	1
R:R:E121	R:R:G122	1.64	1	Yes	No	5	6	1	2
R:R:A300	R:R:L272	1.58	1	No	No	7	6	2	2
R:R:A300	R:R:L297	1.58	1	No	Yes	7	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WF7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	256
Number of Links	278
Number of Hubs	32
Number of Links mediated by Hubs	127
Number of Communities	8
Number of Nodes involved in Communities	45
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	37266
Length Of Smallest Path	3
Average Path Length	13.6295
Length of Longest Path	30
Minimum Path Strength	1.38
Average Path Strength	5.37367
Maximum Path Strength	23.885
Minimum Path Correlation	0.7
Average Path Correlation	0.932924
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	52.9832
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.5268
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	S1P
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	S1P
Name	(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
Synonyms	sphingosine 1-phosphate
Identifier
Formula	C18 H38 N O5 P
Molecular Weight	379.472
SMILES
PubChem	5283560
Formal Charge	0
Total Atoms	63
Total Chiral Atoms	2
Total Bonds	62
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7WF7_nogp_Chain_R D I I V R H Y N Y T G K L N K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V W S L L A I A I E R Y I T M L K M K L H F R L F L L I S A C W V I S L I L G G L P I M G W N C S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F L A L L K T V I I V L S V F I A C W A P L F I L L L L D V K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WF7_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.