psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H28	R:R:I24	6.63	Yes	No	5	8	4
2	R:R:I24	R:R:L197	9.99	No	Yes	5	4	4
3	R:R:I25	R:R:P114	5.08	No	No	0	4	3
4	R:R:H28	R:R:R27	5.64	Yes	No	0	8	3
5	R:R:H28	R:R:L188	3.86	Yes	No	0	8	2
6	R:R:C191	R:R:H28	4.42	No	Yes	0	9	8
7	R:R:H28	R:R:L197	7.71	Yes	Yes	5	8	4
8	R:R:K34	R:R:Y29	3.58	No	Yes	1	6	7
9	R:R:L35	R:R:Y29	5.86	Yes	Yes	0	6	7
10	R:R:P196	R:R:Y29	12.52	No	Yes	0	3	7
11	L:L:?1	R:R:Y29	7.11	Yes	Yes	1	0	7
12	R:R:L35	R:R:N30	8.24	Yes	No	0	6	9
13	R:R:L188	R:R:Y31	7.03	No	No	0	2	5
14	R:R:V284	R:R:Y31	15.14	No	No	0	1	5
15	R:R:P196	R:R:T32	3.5	No	No	0	3	8
16	R:R:F291	R:R:T32	3.89	No	No	0	1	8
17	R:R:G33	R:R:K285	5.23	No	No	0	7	2
18	R:R:F291	R:R:K34	9.93	No	No	0	1	6
19	L:L:?1	R:R:K34	7.48	Yes	No	1	0	6
20	R:R:L35	R:R:N36	6.87	Yes	No	0	6	4
21	R:R:L35	R:R:Y110	3.52	Yes	Yes	0	6	5
22	R:R:K46	R:R:S49	3.06	No	No	0	4	5
23	R:R:F52	R:R:T48	5.19	No	No	0	6	5
24	R:R:T48	R:R:Y295	4.99	No	No	0	5	3
25	R:R:L54	R:R:V50	2.98	No	No	0	4	5
26	R:R:F52	R:R:V298	17.04	No	No	0	6	5
27	R:R:I53	R:R:T99	3.04	Yes	No	0	3	6
28	R:R:I53	R:R:L102	7.14	Yes	No	0	3	5
29	R:R:C56	R:R:T99	5.07	No	No	0	5	6
30	R:R:I59	R:R:S304	3.1	No	No	0	7	9
31	R:R:G305	R:R:I59	3.53	No	No	0	7	7
32	R:R:I60	R:R:V96	3.07	No	No	0	6	5
33	R:R:F65	R:R:L61	12.18	No	No	0	7	4
34	R:R:E62	R:R:F65	3.5	No	No	0	8	7
35	R:R:E62	R:R:P308	4.72	No	No	0	8	9
36	R:R:A88	R:R:N63	3.13	No	No	0	9	9
37	R:R:D91	R:R:N63	4.04	Yes	No	0	9	9
38	R:R:N63	R:R:P308	8.15	No	No	0	9	9
39	R:R:F322	R:R:F65	5.36	No	No	0	7	7
40	R:R:F322	R:R:T69	3.89	No	No	0	7	8
41	R:R:F76	R:R:T73	11.67	Yes	Yes	0	8	6
42	R:R:F76	R:R:Y81	36.1	Yes	No	2	8	9
43	R:R:E317	R:R:F76	4.66	Yes	Yes	2	7	8
44	R:R:F76	R:R:M318	3.73	Yes	Yes	2	8	8
45	R:R:H77	R:R:Y82	7.62	No	No	0	7	4
46	R:R:E141	R:R:M80	6.77	Yes	No	7	9	8
47	R:R:M80	R:R:T145	4.52	No	No	7	8	8
48	R:R:M318	R:R:Y81	3.59	Yes	No	2	8	9
49	R:R:F83	R:R:I138	5.02	Yes	No	0	8	8
50	R:R:E141	R:R:F83	11.66	Yes	Yes	0	9	8
51	R:R:F83	R:R:L160	3.65	Yes	No	0	8	7
52	R:R:I84	R:R:Y311	4.84	No	Yes	0	8	9
53	R:R:N86	R:R:S134	4.47	No	No	0	9	8
54	R:R:N86	R:R:W168	7.91	No	Yes	0	9	9
55	R:R:L87	R:R:S134	3	No	No	0	9	8
56	R:R:L135	R:R:L87	5.54	No	No	0	9	9
57	R:R:L87	R:R:N307	9.61	No	No	0	9	9
58	R:R:A130	R:R:S90	3.42	No	No	8	7	8
59	R:R:S131	R:R:S90	3.26	No	No	0	9	8
60	R:R:S90	R:R:W168	3.71	No	Yes	8	8	9
61	R:R:D91	R:R:S131	5.89	Yes	No	0	9	9
62	R:R:D91	R:R:S304	11.78	Yes	No	0	9	9
63	R:R:D91	R:R:N307	6.73	Yes	No	0	9	9
64	R:R:L102	R:R:Y98	11.72	No	Yes	0	5	6
65	R:R:L297	R:R:Y98	5.86	Yes	Yes	0	5	6
66	R:R:V298	R:R:Y98	3.79	No	Yes	0	5	6
67	R:R:V301	R:R:Y98	3.79	No	Yes	0	7	6
68	R:R:N101	R:R:R120	4.82	No	Yes	1	5	6
69	L:L:?1	R:R:N101	9.36	Yes	No	1	0	5
70	R:R:L104	R:R:Q116	5.32	No	No	0	4	4
71	R:R:L104	R:R:R120	4.86	No	Yes	0	4	6
72	R:R:A107	R:R:Y110	4	No	Yes	1	4	5
73	R:R:A107	R:R:K111	3.21	No	No	1	4	1
74	R:R:K111	R:R:T108	3	No	No	0	1	4
75	R:R:L112	R:R:T108	7.37	No	No	0	5	4
76	R:R:T109	R:R:Y110	3.75	No	Yes	1	5	5
77	R:R:R120	R:R:T109	3.88	Yes	No	1	6	5
78	L:L:?1	R:R:T109	5.58	Yes	No	1	0	5
79	R:R:K111	R:R:Y110	4.78	No	Yes	1	1	5
80	R:R:P114	R:R:T113	3.5	No	No	0	3	7
81	R:R:F118	R:R:W117	7.02	No	Yes	0	6	9
82	R:R:R120	R:R:W117	5	Yes	Yes	0	6	9
83	R:R:E121	R:R:W117	11.99	Yes	Yes	0	5	9
84	R:R:L197	R:R:W117	4.56	Yes	Yes	0	4	9
85	R:R:F118	R:R:I179	7.54	No	No	0	6	5
86	L:L:?1	R:R:R120	9.2	Yes	Yes	1	0	6
87	R:R:E121	R:R:L195	7.95	Yes	No	1	5	3
88	R:R:E121	R:R:Y198	6.73	Yes	No	0	5	4
89	L:L:?1	R:R:E121	9.04	Yes	Yes	1	0	5
90	R:R:M124	R:R:S123	3.07	No	No	0	6	4
91	L:L:?1	R:R:M124	4.28	Yes	No	0	0	6
92	R:R:F125	R:R:S129	3.96	Yes	No	0	5	6
93	R:R:F125	R:R:L174	3.65	Yes	Yes	1	5	5
94	R:R:F125	R:R:G175	3.01	Yes	No	0	5	6
95	R:R:F125	R:R:Y202	11.35	Yes	Yes	1	5	7
96	R:R:C206	R:R:F125	4.19	No	Yes	0	6	5
97	L:L:?1	R:R:F125	12.92	Yes	Yes	1	0	5
98	R:R:L128	R:R:W269	3.42	No	Yes	0	6	8
99	R:R:S129	R:R:S171	3.26	No	No	0	6	8
100	R:R:A130	R:R:W168	3.89	No	Yes	8	7	9
101	R:R:A130	R:R:S171	3.42	No	No	0	7	8
102	R:R:L213	R:R:V132	4.47	No	No	0	8	7
103	R:R:V132	R:R:W269	3.68	No	Yes	0	7	8
104	R:R:C167	R:R:W133	3.92	No	No	0	6	5
105	R:R:L213	R:R:W133	9.11	No	No	0	8	5
106	R:R:L135	R:R:Y311	3.52	No	Yes	0	9	9
107	R:R:L136	R:R:L213	5.54	Yes	No	0	7	8
108	R:R:L136	R:R:S216	3	Yes	No	0	7	6
109	R:R:I217	R:R:L136	5.71	No	Yes	0	8	7
110	R:R:I138	R:R:Y311	4.84	No	Yes	0	8	9
111	R:R:A139	R:R:Y221	5.34	No	Yes	0	8	9
112	R:R:E141	R:R:T145	4.23	Yes	No	7	9	8
113	R:R:E141	R:R:R159	10.47	Yes	No	0	9	5
114	R:R:R142	R:R:Y221	8.23	No	Yes	3	9	9
115	R:R:R142	R:R:Y311	8.23	No	Yes	3	9	9
116	R:R:L147	R:R:Y143	5.86	No	Yes	0	6	8
117	R:R:R223	R:R:Y143	18.52	No	Yes	0	5	8
118	R:R:I224	R:R:Y143	8.46	No	Yes	0	9	8
119	R:R:L227	R:R:M146	4.24	No	No	0	6	8
120	R:R:L147	R:R:M149	4.24	No	No	0	6	8
121	R:R:K148	R:R:R231	7.43	No	No	0	6	7
122	R:R:F161	R:R:L160	6.09	No	No	0	2	7
123	R:R:F161	R:R:I164	5.02	No	No	0	2	7
124	R:R:I173	R:R:V169	3.07	No	No	0	4	4
125	R:R:L174	R:R:Y202	5.86	Yes	Yes	1	5	7
126	R:R:F205	R:R:L174	3.65	No	Yes	1	5	5
127	R:R:P178	R:R:Y202	5.56	No	Yes	0	5	7
128	R:R:H201	R:R:W182	19.04	No	No	0	4	5
129	R:R:C184	R:R:C191	7.28	No	No	0	5	9
130	R:R:S189	R:R:S190	3.26	No	No	0	4	4
131	R:R:H199	R:R:S190	12.55	Yes	No	0	4	4
132	R:R:K200	R:R:S192	4.59	No	No	0	3	4
133	R:R:D279	R:R:S192	5.89	No	No	0	4	4
134	R:R:D279	R:R:T193	5.78	No	No	0	4	5
135	R:R:F291	R:R:T193	3.89	No	No	0	1	5
136	R:R:D279	R:R:V194	5.84	No	No	0	4	4
137	L:L:?1	R:R:L195	3.15	Yes	No	1	0	3
138	R:R:Y198	R:R:Y202	9.93	No	Yes	0	4	7
139	R:R:I203	R:R:Y198	9.67	No	No	0	6	4
140	R:R:H199	R:R:H201	13.14	Yes	No	0	4	4
141	R:R:K200	R:R:V280	6.07	No	No	0	3	4
142	R:R:F205	R:R:Y202	5.16	No	Yes	1	5	7
143	R:R:I203	R:R:L276	5.71	No	No	0	6	6
144	R:R:F205	R:R:V209	3.93	No	No	0	5	5
145	R:R:C206	R:R:F210	4.19	No	No	0	6	7
146	R:R:F273	R:R:T207	3.89	No	No	0	6	5
147	R:R:F210	R:R:V209	3.93	No	No	0	7	5
148	R:R:F210	R:R:W269	8.02	No	Yes	0	7	8
149	R:R:F273	R:R:T211	3.89	No	No	0	6	4
150	R:R:I266	R:R:L214	4.28	No	No	0	6	5
151	R:R:I219	R:R:V218	3.07	No	No	0	4	4
152	R:R:L262	R:R:V218	4.47	No	No	0	7	4
153	R:R:V258	R:R:Y221	5.05	No	Yes	0	8	9
154	R:R:Y221	R:R:Y311	3.97	Yes	Yes	3	9	9
155	R:R:R229	R:R:Y225	10.29	No	No	0	5	6
156	R:R:L254	R:R:Y225	8.21	Yes	No	0	8	6
157	R:R:L255	R:R:Y225	10.55	No	No	0	8	6
158	R:R:L254	R:R:V228	4.47	Yes	No	0	8	8
159	R:R:R229	R:R:R233	5.33	No	No	0	5	4
160	R:R:A253	R:R:K256	3.21	No	No	0	7	7
161	R:R:L254	R:R:V258	2.98	Yes	No	0	8	8
162	R:R:T257	R:R:T314	4.71	No	No	0	9	7
163	R:R:I259	R:R:I260	4.42	No	No	0	5	6
164	R:R:I310	R:R:V261	3.07	No	No	3	8	8
165	R:R:V261	R:R:Y311	3.79	No	Yes	3	8	9
166	R:R:T306	R:R:V264	4.76	No	No	0	5	7
167	R:R:F265	R:R:W269	8.02	No	Yes	0	9	8
168	R:R:C268	R:R:N303	7.87	No	No	0	8	9
169	R:R:L299	R:R:P271	3.28	No	No	0	7	9
170	R:R:F296	R:R:L275	12.18	No	No	0	4	4
171	R:R:C287	R:R:L278	3.17	Yes	No	4	3	4
172	R:R:L278	R:R:L290	4.15	No	Yes	4	4	3
173	R:R:K283	R:R:T286	19.52	No	No	0	1	1
174	R:R:C287	R:R:L290	7.94	Yes	Yes	4	3	3
175	R:R:E294	R:R:R292	9.3	No	No	6	3	4
176	R:R:R292	R:R:Y295	5.14	No	No	6	4	3
177	R:R:E294	R:R:Y295	5.61	No	No	6	3	3
178	L:L:?1	R:R:L297	6.29	Yes	Yes	1	0	5
179	R:R:I310	R:R:Y311	4.84	No	Yes	3	8	9
180	R:R:L313	R:R:T312	4.42	No	No	0	6	7
181	R:R:M318	R:R:T312	10.54	Yes	No	0	8	7
182	R:R:E317	R:R:N315	3.94	Yes	No	0	7	8
183	R:R:M318	R:R:N315	8.41	Yes	No	0	8	8
184	R:R:E317	R:R:K316	4.05	Yes	No	2	7	6
185	R:R:K316	R:R:R320	14.85	No	No	2	6	5
186	R:R:E317	R:R:R320	6.98	Yes	No	2	7	5
187	R:R:C184	R:R:H199	2.95	No	Yes	0	5	4
188	R:R:L290	R:R:T193	2.95	Yes	No	0	3	5
189	R:R:L204	R:R:T207	2.95	No	No	0	5	5
190	R:R:I140	R:R:I144	2.94	No	No	0	6	4
191	R:R:I260	R:R:I310	2.94	No	No	0	6	8
192	R:R:A187	R:R:H199	2.93	No	Yes	0	4	4
193	R:R:I70	R:R:M318	2.92	No	Yes	0	7	8
194	R:R:I224	R:R:M146	2.92	No	No	0	9	8
195	R:R:P79	R:R:R78	2.88	No	No	0	7	7
196	R:R:K150	R:R:M149	2.88	No	No	0	7	8
197	R:R:I25	R:R:L197	2.85	No	Yes	0	4	4
198	R:R:I53	R:R:L103	2.85	Yes	No	0	3	6
199	R:R:I64	R:R:L61	2.85	No	No	0	4	4
200	R:R:I70	R:R:L67	2.85	No	No	0	7	8
201	R:R:I140	R:R:L136	2.85	No	Yes	0	6	7
202	R:R:I309	R:R:L313	2.85	No	No	0	6	6
203	R:R:K148	R:R:L151	2.82	No	No	0	6	4
204	R:R:A137	R:R:F83	2.77	No	Yes	0	7	8
205	R:R:L252	R:R:L254	2.77	No	Yes	0	5	8
206	R:R:L272	R:R:L297	2.77	No	Yes	1	6	5
207	R:R:L275	R:R:L278	2.77	No	No	4	4	4
208	R:R:L275	R:R:L290	2.77	No	Yes	4	4	3
209	R:R:F52	R:R:I55	2.51	No	No	0	6	6
210	R:R:F83	R:R:L163	2.44	Yes	No	0	8	6
211	R:R:F265	R:R:L214	2.44	No	No	0	9	5
212	R:R:L235	R:R:R234	2.43	No	No	0	6	4
213	R:R:F265	R:R:N303	2.42	No	No	0	9	9
214	R:R:L220	R:R:Y143	2.34	No	Yes	0	7	8
215	R:R:K72	R:R:W71	2.32	No	No	0	6	3
216	R:R:L93	R:R:W168	2.28	No	Yes	0	6	9
217	R:R:F76	R:R:R78	2.14	Yes	No	0	8	7
218	R:R:G175	R:R:G176	2.11	No	No	0	6	4
219	R:R:F273	R:R:W269	2	No	Yes	0	6	8
220	R:R:A88	R:R:G85	1.95	No	No	0	9	5
221	R:R:A94	R:R:G95	1.95	No	No	0	8	7
222	R:R:A270	R:R:P271	1.87	No	No	0	6	9
223	R:R:G106	R:R:S105	1.86	No	No	0	4	4
224	R:R:G95	R:R:V301	1.84	No	No	0	7	7
225	R:R:G33	R:R:T32	1.82	No	No	0	7	8
226	R:R:A127	R:R:A94	1.79	No	No	0	6	8
227	R:R:P308	R:R:V66	1.77	No	No	0	9	9
228	R:R:G85	R:R:I70	1.76	No	No	0	5	7
229	R:R:G106	R:R:K46	1.74	No	No	0	4	4
230	R:R:A97	R:R:S123	1.71	No	No	0	4	4
231	R:R:C268	R:R:V264	1.71	No	No	0	8	7
232	R:R:C287	R:R:T286	1.69	Yes	No	0	3	1
233	R:R:A321	R:R:T69	1.68	No	No	0	7	8
234	R:R:A321	R:R:T73	1.68	No	Yes	0	7	6
235	R:R:A115	R:R:T113	1.68	No	No	0	2	7
236	R:R:C57	R:R:I53	1.64	No	Yes	0	5	3
237	R:R:E121	R:R:G122	1.64	Yes	No	0	5	6
238	R:R:L177	R:R:P178	1.64	No	No	0	5	5
239	R:R:C222	R:R:I219	1.64	No	No	0	3	4
240	R:R:C287	R:R:I289	1.64	Yes	No	0	3	3
241	R:R:S171	R:R:V126	1.62	No	No	0	8	5
242	R:R:A270	R:R:I274	1.62	No	No	0	6	5
243	R:R:S226	R:R:T230	1.6	No	No	0	3	5
244	R:R:T257	R:R:V261	1.59	No	No	0	9	8
245	R:R:A139	R:R:L220	1.58	No	No	0	8	7
246	R:R:A300	R:R:L272	1.58	No	No	1	7	6
247	R:R:A300	R:R:L297	1.58	No	Yes	1	7	5
248	R:R:T207	R:R:T208	1.57	No	No	0	5	4
249	R:R:I164	R:R:S165	1.55	No	No	0	7	4
250	R:R:I55	R:R:V51	1.54	No	No	0	6	5
251	R:R:I60	R:R:T99	1.52	No	No	0	6	6
252	R:R:L102	R:R:S49	1.5	No	No	0	5	5
253	R:R:K72	R:R:T73	1.5	No	Yes	0	6	6
254	R:R:K75	R:R:T73	1.5	No	Yes	0	6	6
255	R:R:L212	R:R:S216	1.5	No	No	0	5	6
256	R:R:L35	R:R:V26	1.49	Yes	No	0	6	6
257	R:R:L92	R:R:V96	1.49	No	No	0	6	5
258	R:R:L172	R:R:V126	1.49	No	No	0	4	5
259	R:R:L215	R:R:V218	1.49	No	No	0	4	4
260	R:R:I55	R:R:L302	1.43	No	No	0	6	6
261	R:R:I59	R:R:L302	1.43	No	No	0	7	6
262	R:R:I170	R:R:L174	1.43	No	Yes	0	4	5
263	R:R:I217	R:R:L262	1.43	No	No	0	8	7
264	R:R:L151	R:R:M146	1.41	No	No	0	4	8
265	R:R:K148	R:R:L227	1.41	No	No	0	6	6
266	R:R:L177	R:R:M180	1.41	No	No	0	5	4
267	R:R:K256	R:R:L255	1.41	No	No	0	7	8
268	R:R:D288	R:R:I289	1.4	No	No	0	3	3
269	R:R:L89	R:R:L92	1.38	No	No	0	5	6
270	R:R:L89	R:R:L93	1.38	No	No	0	5	6
271	R:R:L299	R:R:L302	1.38	No	No	0	7	6
272	R:R:L119	R:R:Q116	1.33	No	No	0	4	4
273	R:R:H77	R:R:K74	1.31	No	No	0	7	6
274	R:R:R233	R:R:T236	1.29	No	No	0	4	4
275	R:R:I323	R:R:R324	1.25	No	No	0	3	4
276	R:R:K316	R:R:R319	1.24	No	No	0	6	8
277	R:R:D23	R:R:R27	1.19	No	No	0	7	3
278	R:R:F158	R:R:R159	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H28	5.652	5	5	8
2	R:R:Y29	7.2675	4	1	7
3	R:R:L35	5.196	5	0	6
4	R:R:I53	3.6675	4	0	3
5	R:R:T73	4.0875	4	0	6
6	R:R:F76	11.66	5	2	8
7	R:R:F83	5.108	5	0	8
8	R:R:D91	7.11	4	0	9
9	R:R:Y98	6.29	4	0	6
10	R:R:Y110	4.0125	4	1	5
11	R:R:W117	7.1425	4	0	9
12	R:R:R120	5.552	5	1	6
13	R:R:E121	7.47	5	1	5
14	R:R:F125	6.51333	6	1	5
15	R:R:L136	4.275	4	0	7
16	R:R:E141	8.2825	4	7	9
17	R:R:Y143	8.795	4	0	8
18	R:R:W168	4.4475	4	8	9
19	R:R:L174	3.6475	4	1	5
20	R:R:L197	6.2775	4	5	4
21	R:R:H199	7.8925	4	0	4
22	R:R:Y202	7.572	5	1	7
23	R:R:Y221	5.6475	4	3	9
24	R:R:L254	4.6075	4	0	8
25	R:R:W269	5.028	5	0	8
26	R:R:C287	3.61	4	4	3
27	R:R:L290	4.4525	4	4	3
28	R:R:L297	4.125	4	1	5
29	R:R:Y311	4.86143	7	3	9
30	R:R:E317	4.9075	4	2	7
31	R:R:M318	5.838	5	2	8
32	L:L:?1	7.441	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H28	R:R:L197	41.8079	7.71	Yes	Yes	5	8	4
2	R:R:I25	R:R:L197	12.2305	2.85	No	Yes	0	4	4
3	R:R:L197	R:R:W117	58.8317	4.56	Yes	Yes	0	4	9
4	R:R:R120	R:R:W117	33.8234	5	Yes	Yes	0	6	9
5	L:L:?1	R:R:R120	37.153	9.2	Yes	Yes	1	0	6
6	L:L:?1	R:R:K34	32.7158	7.48	Yes	No	1	0	6
7	R:R:E121	R:R:W117	33.5201	11.99	Yes	Yes	0	5	9
8	L:L:?1	R:R:E121	35.5706	9.04	Yes	Yes	1	0	5
9	L:L:?1	R:R:Y29	14.4788	7.11	Yes	Yes	1	0	7
10	R:R:F291	R:R:K34	32.3268	9.93	No	No	0	1	6
11	L:L:?1	R:R:L297	36.619	6.29	Yes	Yes	1	0	5
12	R:R:L297	R:R:Y98	33.3817	5.86	Yes	Yes	0	5	6
13	R:R:L102	R:R:Y98	17.8611	11.72	No	Yes	0	5	6
14	R:R:F52	R:R:V298	23.7819	17.04	No	No	0	6	5
15	R:R:V298	R:R:Y98	24.2236	3.79	No	Yes	0	5	6
16	R:R:F52	R:R:I55	21.7248	2.51	No	No	0	6	6
17	R:R:I55	R:R:L302	20.8809	1.43	No	No	0	6	6
18	R:R:I59	R:R:L302	18.738	1.43	No	No	0	7	6
19	L:L:?1	R:R:F125	100	12.92	Yes	Yes	1	0	5
20	R:R:F125	R:R:S129	98.0418	3.96	Yes	No	0	5	6
21	R:R:S129	R:R:S171	97.6264	3.26	No	No	0	6	8
22	R:R:A130	R:R:S171	96.499	3.42	No	No	0	7	8
23	R:R:A130	R:R:S90	40.1991	3.42	No	No	8	7	8
24	R:R:S131	R:R:S90	42.5529	3.26	No	No	0	9	8
25	R:R:D91	R:R:S131	42.1705	5.89	Yes	No	0	9	9
26	R:R:D91	R:R:S304	19.2062	11.78	Yes	No	0	9	9
27	R:R:I59	R:R:S304	18.4216	3.1	No	No	0	7	9
28	R:R:E62	R:R:F65	10.0284	3.5	No	No	0	8	7
29	R:R:E62	R:R:P308	11.6239	4.72	No	No	0	8	9
30	R:R:N63	R:R:P308	15.026	8.15	No	No	0	9	9
31	R:R:D91	R:R:N63	56.7416	4.04	Yes	No	0	9	9
32	R:R:A88	R:R:N63	41.1881	3.13	No	No	0	9	9
33	R:R:F76	R:R:M318	18.9358	3.73	Yes	Yes	2	8	8
34	R:R:I70	R:R:M318	35.0696	2.92	No	Yes	0	7	8
35	R:R:G85	R:R:I70	38.142	1.76	No	No	0	5	7
36	R:R:A88	R:R:G85	39.6651	1.95	No	No	0	9	5
37	R:R:F83	R:R:I138	20.8413	5.02	Yes	No	0	8	8
38	R:R:I138	R:R:Y311	22.4698	4.84	No	Yes	0	8	9
39	R:R:L135	R:R:Y311	73.3566	3.52	No	Yes	0	9	9
40	R:R:L135	R:R:L87	74.5896	5.54	No	No	0	9	9
41	R:R:L87	R:R:S134	54.8691	3	No	No	0	9	8
42	R:R:N86	R:R:S134	55.3504	4.47	No	No	0	9	8
43	R:R:N86	R:R:W168	56.1746	7.91	No	Yes	0	9	9
44	R:R:A130	R:R:W168	55.9702	3.89	No	Yes	8	7	9
45	R:R:D91	R:R:N307	23.4852	6.73	Yes	No	0	9	9
46	R:R:C206	R:R:F125	51.2099	4.19	No	Yes	0	6	5
47	R:R:C206	R:R:F210	49.7923	4.19	No	No	0	6	7
48	R:R:F210	R:R:W269	49.2055	8.02	No	Yes	0	7	8
49	R:R:V132	R:R:W269	26.7752	3.68	No	Yes	0	7	8
50	R:R:L213	R:R:V132	25.0742	4.47	No	No	0	8	7
51	R:R:L136	R:R:L213	19.8919	5.54	Yes	No	0	7	8
52	R:R:I217	R:R:L136	11.1096	5.71	No	Yes	0	8	7
53	R:R:A139	R:R:Y221	25.9445	5.34	No	Yes	0	8	9
54	R:R:Y221	R:R:Y311	44.2144	3.97	Yes	Yes	3	9	9
55	R:R:A139	R:R:L220	24.2962	1.58	No	No	0	8	7
56	R:R:L220	R:R:Y143	22.6347	2.34	No	Yes	0	7	8
57	R:R:I224	R:R:Y143	14.1294	8.46	No	Yes	0	9	8
58	R:R:I224	R:R:M146	12.3756	2.92	No	No	0	9	8
59	R:R:C184	R:R:H199	18.2699	2.95	No	Yes	0	5	4
60	R:R:C184	R:R:C191	21.2699	7.28	No	No	0	5	9
61	R:R:C191	R:R:H28	24.2566	4.42	No	Yes	0	9	8
62	R:R:F291	R:R:T193	26.3994	3.89	No	No	0	1	5
63	R:R:F265	R:R:W269	12.9162	8.02	No	Yes	0	9	8
64	R:R:V258	R:R:Y221	19.226	5.05	No	Yes	0	8	9
65	R:R:L254	R:R:V258	17.7029	2.98	Yes	No	0	8	8
66	R:R:L254	R:R:Y225	12.5272	8.21	Yes	No	0	8	6
67	R:R:L290	R:R:T193	16.1931	2.95	Yes	No	0	3	5
68	R:R:F125	R:R:Y202	10.7272	11.35	Yes	Yes	1	5	7
69	R:R:L87	R:R:N307	22.3907	9.61	No	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K34	R:R:Y29	3.58	1	No	Yes	6	7	1	1
R:R:L35	R:R:Y29	5.86	0	Yes	Yes	6	7	2	1
R:R:P196	R:R:Y29	12.52	0	No	Yes	3	7	2	1
L:L:?1	R:R:Y29	7.11	1	Yes	Yes	0	7	0	1
R:R:F291	R:R:K34	9.93	0	No	No	1	6	2	1
L:L:?1	R:R:K34	7.48	1	Yes	No	0	6	0	1
R:R:L35	R:R:Y110	3.52	0	Yes	Yes	6	5	2	2
R:R:L297	R:R:Y98	5.86	1	Yes	Yes	5	6	1	2
R:R:N101	R:R:R120	4.82	1	No	Yes	5	6	1	1
L:L:?1	R:R:N101	9.36	1	Yes	No	0	5	0	1
R:R:L104	R:R:R120	4.86	0	No	Yes	4	6	2	1
R:R:T109	R:R:Y110	3.75	1	No	Yes	5	5	1	2
R:R:R120	R:R:T109	3.88	1	Yes	No	6	5	1	1
L:L:?1	R:R:T109	5.58	1	Yes	No	0	5	0	1
R:R:R120	R:R:W117	5	1	Yes	Yes	6	9	1	2
R:R:E121	R:R:W117	11.99	1	Yes	Yes	5	9	1	2
L:L:?1	R:R:R120	9.2	1	Yes	Yes	0	6	0	1
R:R:E121	R:R:L195	7.95	1	Yes	No	5	3	1	1
R:R:E121	R:R:Y198	6.73	1	Yes	No	5	4	1	2
L:L:?1	R:R:E121	9.04	1	Yes	Yes	0	5	0	1
R:R:M124	R:R:S123	3.07	0	No	No	6	4	1	2
L:L:?1	R:R:M124	4.28	1	Yes	No	0	6	0	1
R:R:F125	R:R:S129	3.96	1	Yes	No	5	6	1	2
R:R:F125	R:R:L174	3.65	1	Yes	Yes	5	5	1	2
R:R:F125	R:R:G175	3.01	1	Yes	No	5	6	1	2
R:R:F125	R:R:Y202	11.35	1	Yes	Yes	5	7	1	2
R:R:C206	R:R:F125	4.19	0	No	Yes	6	5	2	1
L:L:?1	R:R:F125	12.92	1	Yes	Yes	0	5	0	1
R:R:L174	R:R:Y202	5.86	1	Yes	Yes	5	7	2	2
L:L:?1	R:R:L195	3.15	1	Yes	No	0	3	0	1
R:R:Y198	R:R:Y202	9.93	0	No	Yes	4	7	2	2
L:L:?1	R:R:L297	6.29	1	Yes	Yes	0	5	0	1
R:R:L272	R:R:L297	2.77	1	No	Yes	6	5	2	1
R:R:E121	R:R:G122	1.64	1	Yes	No	5	6	1	2
R:R:A300	R:R:L272	1.58	1	No	No	7	6	2	2
R:R:A300	R:R:L297	1.58	1	No	Yes	7	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WF7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	256
Number of Links	278
Number of Hubs	32
Number of Links mediated by Hubs	127
Number of Communities	8
Number of Nodes involved in Communities	45
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	37266
Length Of Smallest Path	3
Average Path Length	13.6295
Length of Longest Path	30
Minimum Path Strength	1.38
Average Path Strength	5.37367
Maximum Path Strength	23.885
Minimum Path Correlation	0.7
Average Path Correlation	0.932891
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	52.9821
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.5268
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • sphingolipid binding • lipid binding • bioactive lipid receptor activity • sphingosine-1-phosphate receptor activity • signaling receptor binding • G protein-coupled receptor binding • head development • central nervous system development • brain development • nervous system development • cell adhesion • regulation of cell adhesion • lamellipodium assembly • plasma membrane bounded cell projection organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component organization • cellular component biogenesis • cellular component assembly • lamellipodium organization • cellular component organization or biogenesis • cell projection assembly • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of actin filament-based process • negative regulation of biological process • regulation of actin filament bundle assembly • actin filament bundle organization • actin filament-based process • negative regulation of cellular process • stress fiber assembly • negative regulation of supramolecular fiber organization • regulation of actin filament organization • negative regulation of stress fiber assembly • actin cytoskeleton organization • actomyosin structure organization • negative regulation of cellular component organization • negative regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • negative regulation of actin filament bundle assembly • regulation of organelle organization • regulation of stress fiber assembly • organelle organization • negative regulation of organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • heart trabecula morphogenesis • trabecula morphogenesis • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • cellular developmental process • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • homeostatic process • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • regulation of multicellular organismal process • regulation of multicellular organismal development • regulation of developmental process • bone mineralization • regulation of biomineral tissue development • regulation of bone mineralization • ossification • biomineral tissue development • regulation of ossification • chemotaxis • taxis • response to external stimulus • locomotion • metabolic process • regulation of metabolic process • positive chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of positive chemotaxis • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • regulation of positive chemotaxis • positive regulation of response to external stimulus • regulation of response to stimulus • regulation of locomotion • transmission of nerve impulse • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • positive regulation of cellular process • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • developmental growth • heart morphogenesis • organ growth • striated muscle tissue development • muscle structure development • cardiac muscle tissue growth involved in heart morphogenesis • animal organ morphogenesis • cardiac muscle tissue growth • muscle tissue development • muscle organ development • heart development • heart growth • cardiac muscle tissue development • growth • muscle tissue morphogenesis • developmental growth involved in morphogenesis • tissue morphogenesis • cardiac muscle tissue morphogenesis • growth involved in heart morphogenesis • muscle organ morphogenesis • cell chemotaxis • leukocyte chemotaxis • sphingolipid mediated signaling pathway • sphingosine-1-phosphate receptor signaling pathway • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • blood vessel maturation • developmental maturation • anatomical structure maturation • cell surface • external side of plasma membrane • membrane microdomain • membrane raft • presynapse • endosome • intracellular vesicle • cytoplasmic vesicle
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	S1P
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	S1P
Name	(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
Synonyms	sphingosine 1-phosphate
Identifier
Formula	C18 H38 N O5 P
Molecular Weight	379.472
SMILES
PubChem	10883396
Formal Charge	0
Total Atoms	63
Total Chiral Atoms	2
Total Bonds	62
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7WF7_nogp_Chain_R D I I V R H Y N Y T G K L N K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V W S L L A I A I E R Y I T M L K M K L H F R L F L L I S A C W V I S L I L G G L P I M G W N C S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F L A L L K T V I I V L S V F I A C W A P L F I L L L L D V K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	10.7554/eLife.88204
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-		2.83	2022-09-28	10.1073/pnas.2117716119
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	10.1073/pnas.2117716119
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	10.1038/s41467-022-28417-2
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	10.1038/s41467-022-28417-2
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-	Gi1/β1/γ2	2.86	2022-01-05	10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-		2.86	2022-01-05	10.1038/s41589-021-00930-3
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	10.1038/s41589-021-00930-3
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	10.1038/s41422-021-00566-x
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	10.1038/s41422-021-00566-x
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	10.1126/science.1215904
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	10.1126/science.1215904

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