psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D18	R:R:V20	4.38	No	No	0	6	5
2	R:R:N183	R:R:Y19	4.65	Yes	No	0	5	8
3	R:R:D23	R:R:N21	5.39	No	No	0	7	8
4	R:R:T113	R:R:Y22	6.24	Yes	No	0	7	5
5	R:R:I24	R:R:R27	6.26	No	No	0	4	3
6	R:R:I185	R:R:I24	5.89	No	No	0	3	4
7	R:R:I25	R:R:W117	5.87	No	Yes	0	4	9
8	R:R:L188	R:R:R27	6.07	No	No	0	2	3
9	R:R:C184	R:R:H28	5.9	No	Yes	1	5	8
10	R:R:H28	R:R:L188	12.86	Yes	No	0	8	2
11	R:R:C191	R:R:H28	4.42	No	Yes	1	9	8
12	R:R:H28	R:R:L197	10.29	Yes	No	1	8	4
13	R:R:K34	R:R:Y29	8.36	Yes	Yes	1	6	7
14	R:R:T109	R:R:Y29	6.24	No	Yes	0	5	7
15	R:R:Y110	R:R:Y29	6.95	No	Yes	0	5	7
16	R:R:W117	R:R:Y29	8.68	Yes	Yes	1	9	7
17	R:R:P196	R:R:Y29	18.08	No	Yes	1	3	7
18	L:L:?1	R:R:Y29	6.21	Yes	Yes	1	0	7
19	R:R:L35	R:R:N30	5.49	No	No	2	6	9
20	H:H:?1	R:R:N30	27.11	No	No	2	0	9
21	R:R:L188	R:R:Y31	7.03	No	No	0	2	5
22	R:R:V284	R:R:Y31	7.57	No	No	0	1	5
23	R:R:K34	R:R:T32	4.5	Yes	No	1	6	8
24	R:R:P196	R:R:T32	8.74	No	No	1	3	8
25	R:R:G33	R:R:K285	5.23	No	No	0	7	2
26	R:R:K34	R:R:P196	5.02	Yes	No	1	6	3
27	L:L:?1	R:R:K34	4.67	Yes	Yes	1	0	6
28	H:H:?1	R:R:L35	4.97	No	No	2	0	6
29	R:R:K46	R:R:T48	7.51	No	No	0	4	5
30	R:R:F52	R:R:T48	6.49	Yes	No	0	6	5
31	R:R:F52	R:R:L102	6.09	Yes	No	0	6	5
32	R:R:E294	R:R:F52	7	No	Yes	0	3	6
33	R:R:F52	R:R:V298	10.49	Yes	No	0	6	5
34	R:R:C56	R:R:Y98	5.38	No	Yes	0	5	6
35	R:R:C56	R:R:T99	6.76	No	No	0	5	6
36	R:R:E62	R:R:F58	17.49	No	No	0	8	4
37	R:R:G305	R:R:I59	7.05	No	No	0	7	7
38	R:R:I60	R:R:L92	4.28	No	No	0	6	6
39	R:R:E62	R:R:P308	4.72	No	Yes	0	8	9
40	R:R:D91	R:R:N63	6.73	Yes	No	0	9	9
41	R:R:N63	R:R:P308	8.15	No	Yes	0	9	9
42	R:R:I64	R:R:L92	5.71	No	No	0	4	6
43	R:R:M318	R:R:T69	4.52	Yes	No	0	8	8
44	R:R:I70	R:R:Y81	6.04	No	Yes	0	7	9
45	R:R:K72	R:R:T73	6.01	No	No	0	6	6
46	R:R:F76	R:R:T73	20.75	No	No	0	8	6
47	R:R:F76	R:R:Y81	20.63	No	Yes	0	8	9
48	R:R:H77	R:R:Y82	4.36	No	No	0	7	4
49	R:R:R78	R:R:Y81	5.14	No	Yes	0	7	9
50	R:R:P79	R:R:S155	5.34	No	No	0	7	7
51	R:R:E141	R:R:M80	5.41	No	No	0	9	8
52	R:R:M80	R:R:R142	4.96	No	Yes	0	8	9
53	R:R:N315	R:R:Y81	5.81	No	Yes	3	8	9
54	R:R:M318	R:R:Y81	8.38	Yes	Yes	3	8	9
55	R:R:L160	R:R:Y82	5.86	Yes	No	0	7	4
56	R:R:E141	R:R:F83	11.66	No	Yes	0	9	8
57	R:R:F83	R:R:L160	7.31	Yes	Yes	4	8	7
58	R:R:F83	R:R:L163	4.87	Yes	No	0	8	6
59	R:R:F83	R:R:I164	6.28	Yes	No	4	8	7
60	R:R:N86	R:R:S134	5.96	No	No	0	9	8
61	R:R:I164	R:R:N86	15.58	No	No	0	7	9
62	R:R:N86	R:R:W168	6.78	No	Yes	0	9	9
63	R:R:D91	R:R:L87	9.5	Yes	Yes	1	9	9
64	R:R:L87	R:R:S134	4.5	Yes	No	0	9	8
65	R:R:L135	R:R:L87	6.92	No	Yes	1	9	9
66	R:R:I138	R:R:L87	4.28	No	Yes	0	8	9
67	R:R:L87	R:R:N307	6.87	Yes	Yes	1	9	9
68	R:R:S134	R:R:S90	6.52	No	No	0	8	8
69	R:R:D91	R:R:S131	4.42	Yes	No	0	9	9
70	R:R:D91	R:R:S304	8.83	Yes	No	0	9	9
71	R:R:D91	R:R:N307	12.12	Yes	Yes	1	9	9
72	R:R:L102	R:R:Y98	14.07	No	Yes	0	5	6
73	R:R:M124	R:R:Y98	8.38	No	Yes	1	6	6
74	R:R:E294	R:R:Y98	11.22	No	Yes	1	3	6
75	R:R:L297	R:R:Y98	10.55	Yes	Yes	1	5	6
76	R:R:V298	R:R:Y98	8.83	No	Yes	0	5	6
77	R:R:V301	R:R:Y98	13.88	No	Yes	0	7	6
78	R:R:N101	R:R:R120	7.23	No	Yes	1	5	6
79	L:L:?1	R:R:N101	13.64	Yes	No	1	0	5
80	L:L:?1	R:R:S105	4.97	Yes	No	0	0	4
81	R:R:R120	R:R:T109	6.47	Yes	No	0	6	5
82	R:R:L112	R:R:Q116	11.98	No	No	0	5	4
83	R:R:Q116	R:R:T113	14.17	No	Yes	0	4	7
84	R:R:F118	R:R:W117	5.01	Yes	Yes	1	6	9
85	R:R:R120	R:R:W117	7	Yes	Yes	1	6	9
86	R:R:E121	R:R:W117	15.27	Yes	Yes	1	5	9
87	R:R:L197	R:R:W117	13.67	No	Yes	1	4	9
88	R:R:W117	R:R:Y198	4.82	Yes	Yes	1	9	4
89	R:R:F118	R:R:I179	6.28	Yes	No	0	6	5
90	R:R:F118	R:R:N183	9.67	Yes	Yes	0	6	5
91	R:R:F118	R:R:L197	6.09	Yes	No	1	6	4
92	R:R:E121	R:R:R120	13.96	Yes	Yes	1	5	6
93	L:L:?1	R:R:R120	5.63	Yes	Yes	1	0	6
94	R:R:E121	R:R:L195	9.28	Yes	Yes	1	5	3
95	R:R:E121	R:R:Y198	5.61	Yes	Yes	1	5	4
96	L:L:?1	R:R:E121	11.41	Yes	Yes	1	0	5
97	R:R:L297	R:R:M124	4.24	Yes	No	1	5	6
98	R:R:F125	R:R:Y198	11.35	No	Yes	1	5	4
99	R:R:F125	R:R:Y202	7.22	No	Yes	1	5	7
100	L:L:?1	R:R:F125	26.62	Yes	No	1	0	5
101	R:R:L128	R:R:W269	9.11	No	Yes	1	6	8
102	L:L:?1	R:R:L128	6.42	Yes	No	1	0	6
103	R:R:S129	R:R:S171	6.52	No	No	0	6	8
104	L:L:?1	R:R:S129	8.95	Yes	No	0	0	6
105	R:R:L213	R:R:V132	5.96	No	No	0	8	7
106	R:R:V132	R:R:W269	4.9	No	Yes	0	7	8
107	R:R:F133	R:R:I170	5.02	No	No	0	5	4
108	R:R:F133	R:R:L213	13.4	No	No	0	5	8
109	R:R:F265	R:R:L135	4.87	Yes	No	1	9	9
110	R:R:L135	R:R:N307	6.87	No	Yes	1	9	9
111	R:R:I140	R:R:L136	7.14	No	No	0	6	7
112	R:R:I217	R:R:L136	4.28	No	No	0	8	7
113	R:R:I138	R:R:R142	6.26	No	Yes	0	8	9
114	R:R:A139	R:R:L220	4.73	No	No	0	8	7
115	R:R:A139	R:R:Y221	5.34	No	No	0	8	9
116	R:R:I140	R:R:L163	4.28	No	No	0	6	6
117	R:R:E141	R:R:T145	4.23	No	No	0	9	8
118	R:R:R142	R:R:Y221	9.26	Yes	No	0	9	9
119	R:R:R142	R:R:Y311	6.17	Yes	Yes	0	9	9
120	R:R:L147	R:R:Y143	5.86	No	Yes	0	6	8
121	R:R:L220	R:R:Y143	4.69	No	Yes	0	7	8
122	R:R:R223	R:R:Y143	17.49	No	Yes	0	5	8
123	R:R:I144	R:R:R159	5.01	No	No	0	4	5
124	R:R:N153	R:R:T145	4.39	No	No	0	4	8
125	R:R:K148	R:R:K150	5.75	No	No	0	6	7
126	R:R:M149	R:R:R231	16.13	No	No	0	8	7
127	R:R:K150	R:R:N153	9.79	No	No	0	7	4
128	R:R:N156	R:R:R159	12.05	No	No	0	7	5
129	R:R:I164	R:R:L160	5.71	No	Yes	4	7	7
130	R:R:F161	R:R:S165	7.93	No	No	0	2	4
131	R:R:L177	R:R:W182	4.56	No	Yes	0	5	5
132	R:R:P178	R:R:Y198	9.74	No	Yes	1	5	4
133	R:R:P178	R:R:Y202	15.3	No	Yes	1	5	7
134	R:R:H199	R:R:W182	5.29	No	Yes	0	4	5
135	R:R:W182	R:R:Y202	9.65	Yes	Yes	0	5	7
136	R:R:I185	R:R:N183	11.33	No	Yes	0	3	5
137	R:R:C184	R:R:C191	7.28	No	No	1	5	9
138	R:R:H199	R:R:S190	9.76	No	No	0	4	4
139	R:R:I203	R:R:S192	4.64	No	No	0	6	4
140	R:R:D279	R:R:S192	5.89	Yes	No	0	4	4
141	R:R:D279	R:R:T193	5.78	Yes	No	1	4	5
142	R:R:L290	R:R:T193	7.37	Yes	No	1	3	5
143	R:R:L195	R:R:V194	4.47	Yes	Yes	1	3	4
144	R:R:L276	R:R:V194	4.47	No	Yes	1	6	4
145	R:R:D279	R:R:V194	7.3	Yes	Yes	1	4	4
146	L:L:?1	R:R:V194	4.93	Yes	Yes	1	0	4
147	R:R:L195	R:R:Y198	12.89	Yes	Yes	1	3	4
148	L:L:?1	R:R:L195	9.17	Yes	Yes	1	0	3
149	R:R:Y198	R:R:Y202	4.96	Yes	Yes	1	4	7
150	R:R:H199	R:R:H201	9.55	No	No	0	4	4
151	R:R:C206	R:R:Y202	9.41	No	Yes	0	6	7
152	L:L:?1	R:R:C206	5.25	Yes	No	0	0	6
153	R:R:L277	R:R:T207	4.42	No	No	0	6	5
154	R:R:F210	R:R:F265	4.29	Yes	Yes	1	7	9
155	R:R:F210	R:R:W269	14.03	Yes	Yes	1	7	8
156	R:R:F210	R:R:F273	7.5	Yes	Yes	0	7	6
157	L:L:?1	R:R:F210	8.07	Yes	Yes	1	0	7
158	R:R:F265	R:R:L214	4.87	Yes	No	0	9	5
159	R:R:I266	R:R:L214	7.14	No	No	0	6	5
160	R:R:L262	R:R:V218	7.45	No	No	0	7	4
161	R:R:L262	R:R:Y221	4.69	No	No	0	7	9
162	R:R:R229	R:R:Y225	7.2	No	No	0	5	6
163	R:R:L254	R:R:Y225	4.69	No	No	0	8	6
164	R:R:L255	R:R:Y225	16.41	No	No	0	8	6
165	R:R:L227	R:R:R231	6.07	No	No	0	6	7
166	R:R:L254	R:R:V228	4.47	No	No	0	8	8
167	R:R:R229	R:R:R233	13.86	No	No	0	5	4
168	R:R:K239	R:R:R238	8.66	No	No	0	2	5
169	R:R:E249	R:R:S248	4.31	No	No	0	5	4
170	R:R:I259	R:R:L255	4.28	No	No	0	5	8
171	R:R:I259	R:R:K256	5.82	No	No	0	5	7
172	R:R:I260	R:R:K256	7.27	No	No	0	6	7
173	R:R:T257	R:R:T314	4.71	No	No	0	9	7
174	R:R:I260	R:R:I310	4.42	No	No	0	6	8
175	R:R:T306	R:R:V264	4.76	No	No	0	5	7
176	R:R:I310	R:R:V264	4.61	No	No	0	8	7
177	R:R:F265	R:R:W269	7.02	Yes	Yes	1	9	8
178	R:R:F265	R:R:N303	8.46	Yes	Yes	1	9	9
179	R:R:C268	R:R:N303	6.3	No	Yes	0	8	9
180	R:R:A300	R:R:W269	7.78	No	Yes	0	7	8
181	R:R:N303	R:R:W269	9.04	Yes	Yes	1	9	8
182	L:L:?1	R:R:W269	5.28	Yes	Yes	1	0	8
183	R:R:F296	R:R:P271	4.33	No	No	0	4	9
184	R:R:L272	R:R:L276	6.92	No	No	0	6	6
185	R:R:F273	R:R:L277	13.4	Yes	No	0	6	6
186	R:R:F296	R:R:L275	14.61	No	No	0	4	4
187	L:L:?1	R:R:L276	6.42	Yes	No	1	0	6
188	R:R:D279	R:R:L290	5.43	Yes	Yes	1	4	3
189	R:R:C282	R:R:T286	5.07	No	No	0	4	1
190	R:R:C282	R:R:C287	7.28	No	No	0	4	3
191	R:R:K283	R:R:T286	16.52	No	No	0	1	1
192	R:R:C287	R:R:L290	4.76	No	Yes	0	3	3
193	R:R:R292	R:R:Y295	18.52	No	No	0	4	3
194	R:R:E294	R:R:L297	5.3	No	Yes	1	3	5
195	L:L:?1	R:R:L297	12.83	Yes	Yes	1	0	5
196	R:R:N303	R:R:T306	4.39	Yes	No	0	9	5
197	R:R:N303	R:R:N307	9.54	Yes	Yes	1	9	9
198	R:R:I310	R:R:Y311	6.04	No	Yes	0	8	9
199	R:R:M318	R:R:T312	7.53	Yes	No	0	8	7
200	R:R:E317	R:R:N315	6.57	No	No	0	7	8
201	R:R:M318	R:R:N315	9.82	Yes	No	3	8	8
202	R:R:C167	R:R:F133	4.19	No	No	0	6	5
203	R:R:A321	R:R:F76	4.16	No	No	0	7	8
204	R:R:L147	R:R:L227	4.15	No	No	0	6	6
205	R:R:E62	R:R:I309	4.1	No	No	0	8	6
206	R:R:G305	R:R:P308	4.06	No	Yes	0	7	9
207	R:R:F205	R:R:W182	4.01	No	Yes	0	5	5
208	L:L:?1	R:R:V209	3.95	Yes	No	0	0	5
209	R:R:R229	R:R:S251	3.95	No	No	0	5	7
210	R:R:A130	R:R:W168	3.89	No	Yes	0	7	9
211	R:R:H152	R:R:L151	3.86	No	No	0	7	4
212	R:R:V261	R:R:Y311	3.79	No	Yes	0	8	9
213	R:R:F273	R:R:I274	3.77	Yes	No	0	6	5
214	R:R:G106	R:R:S105	3.71	No	No	0	4	4
215	R:R:F205	R:R:L174	3.65	No	No	0	5	5
216	R:R:F237	R:R:L235	3.65	No	No	0	3	6
217	R:R:L112	R:R:R120	3.64	No	Yes	0	5	6
218	R:R:I84	R:R:Y311	3.63	No	Yes	0	8	9
219	R:R:I224	R:R:Y143	3.63	No	Yes	0	9	8
220	R:R:D288	R:R:F291	3.58	No	No	0	3	1
221	R:R:D23	R:R:R27	3.57	No	No	0	7	3
222	R:R:G154	R:R:K150	3.49	No	No	0	4	7
223	R:R:A97	R:R:S123	3.42	No	No	0	4	4
224	R:R:A88	R:R:V66	3.39	No	No	0	9	9
225	R:R:A293	R:R:V194	3.39	No	Yes	0	4	4
226	R:R:S189	R:R:S190	3.26	No	No	0	4	4
227	R:R:S232	R:R:S251	3.26	No	No	0	5	7
228	R:R:A97	R:R:M124	3.22	No	No	0	4	6
229	R:R:C57	R:R:L54	3.17	No	No	0	5	4
230	R:R:C287	R:R:L278	3.17	No	No	0	3	4
231	R:R:A88	R:R:L67	3.15	No	No	0	9	8
232	R:R:A127	R:R:L93	3.15	No	No	0	6	6
233	R:R:I45	R:R:S49	3.1	No	No	0	4	5
234	R:R:I55	R:R:V51	3.07	No	No	0	6	5
235	R:R:I60	R:R:V96	3.07	No	No	0	6	5
236	R:R:I173	R:R:V169	3.07	No	No	0	4	4
237	R:R:I203	R:R:V280	3.07	No	No	0	6	4
238	R:R:K250	R:R:S232	3.06	No	No	0	6	5
239	R:R:K75	R:R:T73	3	No	No	0	6	6
240	R:R:K111	R:R:T108	3	No	No	0	1	4
241	R:R:L172	R:R:V126	2.98	No	No	0	4	5
242	R:R:L103	R:R:T99	2.95	No	No	0	6	6
243	R:R:I55	R:R:I59	2.94	No	No	0	6	7
244	R:R:I70	R:R:I84	2.94	No	No	0	7	8
245	R:R:I144	R:R:K148	2.91	No	No	0	4	6
246	R:R:P79	R:R:R78	2.88	No	No	0	7	7
247	R:R:I64	R:R:L68	2.85	No	No	0	4	4
248	R:R:I179	R:R:L119	2.85	No	No	0	5	4
249	R:R:I289	R:R:L290	2.85	No	Yes	0	3	3
250	R:R:I309	R:R:L313	2.85	No	No	0	6	6
251	R:R:A137	R:R:F83	2.77	No	Yes	0	7	8
252	R:R:L272	R:R:L275	2.77	No	No	0	6	4
253	R:R:L275	R:R:L290	2.77	No	Yes	0	4	3
254	R:R:F273	R:R:T211	2.59	Yes	No	0	6	4
255	R:R:R234	R:R:T230	2.59	No	No	0	4	5
256	R:R:I219	R:R:R223	2.51	No	No	0	4	5
257	R:R:F291	R:R:K34	2.48	No	Yes	0	1	6
258	R:R:L104	R:R:R120	2.43	No	Yes	0	4	6
259	R:R:N36	R:R:Y110	2.33	No	No	0	4	5
260	R:R:L89	R:R:W168	2.28	No	Yes	0	5	9
261	R:R:L93	R:R:W168	2.28	No	Yes	0	6	9
262	R:R:R231	R:R:R234	2.13	No	No	0	7	4
263	R:R:G175	R:R:G176	2.11	No	No	0	6	4
264	R:R:F52	R:R:Y295	2.06	Yes	No	0	6	3
265	R:R:G176	R:R:P178	2.03	No	No	0	4	5
266	R:R:A88	R:R:G85	1.95	No	No	0	9	5
267	R:R:A94	R:R:G95	1.95	No	No	0	8	7
268	R:R:A270	R:R:P271	1.87	No	No	0	6	9
269	R:R:G175	R:R:V126	1.84	No	No	0	6	5
270	R:R:A127	R:R:A94	1.79	No	No	0	6	8
271	R:R:P308	R:R:V66	1.77	Yes	No	0	9	9
272	R:R:G95	R:R:I60	1.76	No	No	0	7	6
273	R:R:P114	R:R:T113	1.75	No	Yes	0	3	7
274	R:R:G176	R:R:M180	1.75	No	No	0	4	4
275	R:R:C222	R:R:V218	1.71	No	No	0	3	4
276	R:R:G181	R:R:N183	1.7	No	Yes	0	5	5
277	R:R:A115	R:R:T113	1.68	No	Yes	0	2	7
278	R:R:E121	R:R:G122	1.64	Yes	No	0	5	6
279	R:R:L299	R:R:P271	1.64	No	No	0	7	9
280	R:R:S49	R:R:V50	1.62	No	No	0	5	5
281	R:R:A107	R:R:K111	1.61	No	No	0	4	1
282	R:R:S226	R:R:T230	1.6	No	No	0	3	5
283	R:R:T208	R:R:V209	1.59	No	No	0	4	5
284	R:R:I259	R:R:S263	1.55	No	No	0	5	5
285	R:R:K46	R:R:S49	1.53	No	No	0	4	5
286	R:R:K200	R:R:S192	1.53	No	No	0	3	4
287	R:R:M146	R:R:V228	1.52	No	No	0	8	8
288	R:R:F291	R:R:G33	1.51	No	No	0	1	7
289	R:R:L136	R:R:S216	1.5	No	No	0	7	6
290	R:R:L35	R:R:V26	1.49	No	No	0	6	6
291	R:R:L54	R:R:V50	1.49	No	No	0	4	5
292	R:R:L204	R:R:V280	1.49	No	No	0	5	4
293	R:R:L254	R:R:V258	1.49	No	No	0	8	8
294	R:R:L262	R:R:V258	1.49	No	No	0	7	8
295	R:R:L104	R:R:T108	1.47	No	No	0	4	4
296	R:R:D23	R:R:V26	1.46	No	No	0	7	6
297	R:R:K74	R:R:K75	1.44	No	No	0	6	6
298	R:R:I53	R:R:L102	1.43	No	No	0	3	5
299	R:R:I53	R:R:L103	1.43	No	No	0	3	6
300	R:R:I55	R:R:L302	1.43	No	No	0	6	6
301	R:R:L162	R:R:L163	1.38	No	No	0	3	6
302	R:R:L160	R:R:N157	1.37	Yes	No	0	7	1
303	R:R:D18	R:R:N21	1.35	No	No	0	6	8
304	R:R:F322	R:R:T69	1.3	No	No	0	7	8
305	R:R:R238	R:R:T236	1.29	No	No	0	5	4
306	R:R:F322	R:R:I323	1.26	No	No	0	7	3
307	R:R:I323	R:R:R320	1.25	No	No	0	3	5
308	R:R:F65	R:R:L61	1.22	No	No	0	7	4
309	R:R:F158	R:R:N156	1.21	No	No	0	4	7
310	R:R:F322	R:R:F65	1.07	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H28	8.3675	4	1	8
2	R:R:Y29	9.08667	6	1	7
3	R:R:K34	5.006	5	1	6
4	R:R:F52	6.426	5	0	6
5	R:R:Y81	9.2	5	3	9
6	R:R:F83	6.578	5	4	8
7	R:R:L87	6.414	5	1	9
8	R:R:D91	8.32	5	1	9
9	R:R:Y98	10.33	7	1	6
10	R:R:T113	5.96	4	0	7
11	R:R:W117	8.61714	7	1	9
12	R:R:F118	6.7625	4	1	6
13	R:R:R120	6.62286	7	1	6
14	R:R:E121	9.52833	6	1	5
15	R:R:R142	6.6625	4	0	9
16	R:R:Y143	7.9175	4	0	8
17	R:R:L160	5.0625	4	4	7
18	R:R:W168	3.8075	4	0	9
19	R:R:W182	5.8775	4	0	5
20	R:R:N183	6.8375	4	0	5
21	R:R:V194	4.912	5	1	4
22	R:R:L195	8.9525	4	1	3
23	R:R:Y198	8.22833	6	1	4
24	R:R:Y202	9.308	5	1	7
25	R:R:F210	8.4725	4	1	7
26	R:R:F265	5.902	5	1	9
27	R:R:W269	8.16571	7	1	8
28	R:R:F273	6.815	4	0	6
29	R:R:D279	6.1	4	1	4
30	R:R:L290	4.636	5	1	3
31	R:R:L297	8.23	4	1	5
32	R:R:N303	7.546	5	1	9
33	R:R:N307	8.85	4	1	9
34	R:R:P308	4.675	4	0	9
35	R:R:Y311	4.9075	4	0	9
36	R:R:M318	7.5625	4	3	8
37	L:L:?1	8.49529	17	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D23	R:R:R27	20.6568	3.57	No	No	0	7	3
2	R:R:L188	R:R:R27	23.0974	6.07	No	No	0	2	3
3	R:R:H28	R:R:L188	30.6789	12.86	Yes	No	0	8	2
4	R:R:H28	R:R:L197	38.2459	10.29	Yes	No	1	8	4
5	R:R:L197	R:R:W117	40.5496	13.67	No	Yes	1	4	9
6	R:R:R120	R:R:W117	21.6489	7	Yes	Yes	1	6	9
7	R:R:W117	R:R:Y29	21.3991	8.68	Yes	Yes	1	9	7
8	L:L:?1	R:R:Y29	24.5027	6.21	Yes	Yes	1	0	7
9	L:L:?1	R:R:R120	30.4314	5.63	Yes	Yes	1	0	6
10	L:L:?1	R:R:E121	27.0635	11.41	Yes	Yes	1	0	5
11	R:R:E121	R:R:W117	21.4063	15.27	Yes	Yes	1	5	9
12	R:R:D23	R:R:V26	10.3656	1.46	No	No	0	7	6
13	L:L:?1	R:R:L297	26.4606	12.83	Yes	Yes	1	0	5
14	R:R:E294	R:R:L297	12.2322	5.3	No	Yes	1	3	5
15	R:R:E294	R:R:F52	11.3217	7	No	Yes	0	3	6
16	L:L:?1	R:R:W269	100	5.28	Yes	Yes	1	0	8
17	R:R:N303	R:R:W269	65.4535	9.04	Yes	Yes	1	9	8
18	R:R:N303	R:R:N307	44.9481	9.54	Yes	Yes	1	9	9
19	R:R:D91	R:R:N307	11.1103	12.12	Yes	Yes	1	9	9
20	R:R:D91	R:R:N63	13.33	6.73	Yes	No	0	9	9
21	R:R:N63	R:R:P308	12.4748	8.15	No	Yes	0	9	9
22	L:L:?1	R:R:F210	37.249	8.07	Yes	Yes	1	0	7
23	R:R:F210	R:R:F265	36.9463	4.29	Yes	Yes	1	7	9
24	R:R:F265	R:R:L135	69.3403	4.87	Yes	No	1	9	9
25	R:R:L135	R:R:L87	68.1248	6.92	No	Yes	1	9	9
26	R:R:L87	R:R:S134	48.4506	4.5	Yes	No	0	9	8
27	R:R:N86	R:R:S134	45.0202	5.96	No	No	0	9	8
28	R:R:N86	R:R:W168	22.3672	6.78	No	Yes	0	9	9
29	R:R:L93	R:R:W168	16.8396	2.28	No	Yes	0	6	9
30	R:R:A127	R:R:L93	14.9875	3.15	No	No	0	6	6
31	R:R:A127	R:R:A94	13.1306	1.79	No	No	0	6	8
32	R:R:A94	R:R:G95	11.2689	1.95	No	No	0	8	7
33	R:R:F265	R:R:W269	35.4449	7.02	Yes	Yes	1	9	8
34	R:R:L87	R:R:N307	33.9195	6.87	Yes	Yes	1	9	9
35	R:R:N303	R:R:T306	22.2398	4.39	Yes	No	0	9	5
36	R:R:T306	R:R:V264	21.7402	4.76	No	No	0	5	7
37	R:R:I310	R:R:V264	21.2813	4.61	No	No	0	8	7
38	R:R:I310	R:R:Y311	15.8187	6.04	No	Yes	0	8	9
39	R:R:I84	R:R:Y311	18.6005	3.63	No	Yes	0	8	9
40	R:R:I70	R:R:I84	17.8053	2.94	No	No	0	7	8
41	R:R:I70	R:R:Y81	17.0054	6.04	No	Yes	0	7	9
42	R:R:I164	R:R:N86	22.3167	15.58	No	No	0	7	9
43	R:R:I138	R:R:L87	60.4281	4.28	No	Yes	0	8	9
44	R:R:I138	R:R:R142	58.9267	6.26	No	Yes	0	8	9
45	R:R:M80	R:R:R142	21.5792	4.96	No	Yes	0	8	9
46	R:R:E141	R:R:M80	19.864	5.41	No	No	0	9	8
47	R:R:F83	R:R:I164	14.0482	6.28	Yes	No	4	8	7
48	R:R:F83	R:R:L163	11.24	4.87	Yes	No	0	8	6
49	R:R:F118	R:R:N183	12.7318	9.67	Yes	Yes	0	6	5
50	R:R:A139	R:R:Y221	24.1016	5.34	No	No	0	8	9
51	R:R:R142	R:R:Y221	39.4999	9.26	Yes	No	0	9	9
52	R:R:A139	R:R:L220	22.2663	4.73	No	No	0	8	7
53	R:R:E141	R:R:T145	16.7075	4.23	No	No	0	9	8
54	R:R:L220	R:R:Y143	20.4262	4.69	No	Yes	0	7	8
55	R:R:L147	R:R:Y143	13.0177	5.86	No	Yes	0	6	8
56	R:R:N153	R:R:T145	14.8554	4.39	No	No	0	4	8
57	R:R:K150	R:R:N153	12.9985	9.79	No	No	0	7	4
58	R:R:L147	R:R:L227	11.1511	4.15	No	No	0	6	6
59	R:R:W182	R:R:Y202	15.0259	9.65	Yes	Yes	0	5	7
60	R:R:P178	R:R:Y198	15.0163	9.74	No	Yes	1	5	4
61	L:L:?1	R:R:V194	16.2487	4.93	Yes	Yes	1	0	4
62	R:R:D279	R:R:V194	16.9477	7.3	Yes	Yes	1	4	4
63	R:R:C206	R:R:Y202	12.1865	9.41	No	Yes	0	6	7
64	L:L:?1	R:R:C206	13.1186	5.25	Yes	No	0	0	6
65	R:R:L262	R:R:Y221	14.6368	4.69	No	No	0	7	9
66	R:R:G176	R:R:P178	20.2244	2.03	No	No	0	4	5
67	R:R:G175	R:R:G176	12.1481	2.11	No	No	0	6	4
68	R:R:F118	R:R:W117	20.1835	5.01	Yes	Yes	1	6	9
69	L:L:?1	R:R:F125	18.156	26.62	Yes	No	1	0	5
70	R:R:F125	R:R:Y202	12.0808	7.22	No	Yes	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K34	R:R:Y29	8.36	1	Yes	Yes	6	7	1	1
R:R:T109	R:R:Y29	6.24	0	No	Yes	5	7	2	1
R:R:Y110	R:R:Y29	6.95	0	No	Yes	5	7	2	1
R:R:W117	R:R:Y29	8.68	1	Yes	Yes	9	7	2	1
R:R:P196	R:R:Y29	18.08	1	No	Yes	3	7	2	1
L:L:?1	R:R:Y29	6.21	1	Yes	Yes	0	7	0	1
R:R:K34	R:R:T32	4.5	1	Yes	No	6	8	1	2
R:R:P196	R:R:T32	8.74	1	No	No	3	8	2	2
R:R:K34	R:R:P196	5.02	1	Yes	No	6	3	1	2
L:L:?1	R:R:K34	4.67	1	Yes	Yes	0	6	0	1
R:R:M124	R:R:Y98	8.38	1	No	Yes	6	6	2	2
R:R:E294	R:R:Y98	11.22	1	No	Yes	3	6	2	2
R:R:L297	R:R:Y98	10.55	1	Yes	Yes	5	6	1	2
R:R:N101	R:R:R120	7.23	1	No	Yes	5	6	1	1
L:L:?1	R:R:N101	13.64	1	Yes	No	0	5	0	1
L:L:?1	R:R:S105	4.97	1	Yes	No	0	4	0	1
R:R:R120	R:R:T109	6.47	1	Yes	No	6	5	1	2
R:R:R120	R:R:W117	7	1	Yes	Yes	6	9	1	2
R:R:E121	R:R:W117	15.27	1	Yes	Yes	5	9	1	2
R:R:W117	R:R:Y198	4.82	1	Yes	Yes	9	4	2	2
R:R:E121	R:R:R120	13.96	1	Yes	Yes	5	6	1	1
L:L:?1	R:R:R120	5.63	1	Yes	Yes	0	6	0	1
R:R:E121	R:R:L195	9.28	1	Yes	Yes	5	3	1	1
R:R:E121	R:R:Y198	5.61	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:E121	11.41	1	Yes	Yes	0	5	0	1
R:R:L297	R:R:M124	4.24	1	Yes	No	5	6	1	2
R:R:F125	R:R:Y198	11.35	1	No	Yes	5	4	1	2
R:R:F125	R:R:Y202	7.22	1	No	Yes	5	7	1	2
L:L:?1	R:R:F125	26.62	1	Yes	No	0	5	0	1
R:R:L128	R:R:W269	9.11	1	No	Yes	6	8	1	1
L:L:?1	R:R:L128	6.42	1	Yes	No	0	6	0	1
R:R:S129	R:R:S171	6.52	0	No	No	6	8	1	2
L:L:?1	R:R:S129	8.95	1	Yes	No	0	6	0	1
R:R:V132	R:R:W269	4.9	0	No	Yes	7	8	2	1
R:R:L195	R:R:V194	4.47	1	Yes	Yes	3	4	1	1
R:R:L276	R:R:V194	4.47	1	No	Yes	6	4	1	1
R:R:D279	R:R:V194	7.3	1	Yes	Yes	4	4	2	1
L:L:?1	R:R:V194	4.93	1	Yes	Yes	0	4	0	1
R:R:L195	R:R:Y198	12.89	1	Yes	Yes	3	4	1	2
L:L:?1	R:R:L195	9.17	1	Yes	Yes	0	3	0	1
R:R:Y198	R:R:Y202	4.96	1	Yes	Yes	4	7	2	2
R:R:C206	R:R:Y202	9.41	0	No	Yes	6	7	1	2
L:L:?1	R:R:C206	5.25	1	Yes	No	0	6	0	1
R:R:F210	R:R:F265	4.29	1	Yes	Yes	7	9	1	2
R:R:F210	R:R:W269	14.03	1	Yes	Yes	7	8	1	1
R:R:F210	R:R:F273	7.5	1	Yes	Yes	7	6	1	2
L:L:?1	R:R:F210	8.07	1	Yes	Yes	0	7	0	1
R:R:F265	R:R:W269	7.02	1	Yes	Yes	9	8	2	1
R:R:F265	R:R:N303	8.46	1	Yes	Yes	9	9	2	2
R:R:A300	R:R:W269	7.78	0	No	Yes	7	8	2	1
R:R:N303	R:R:W269	9.04	1	Yes	Yes	9	8	2	1
L:L:?1	R:R:W269	5.28	1	Yes	Yes	0	8	0	1
R:R:L272	R:R:L276	6.92	0	No	No	6	6	2	1
L:L:?1	R:R:L276	6.42	1	Yes	No	0	6	0	1
R:R:E294	R:R:L297	5.3	1	No	Yes	3	5	2	1
L:L:?1	R:R:L297	12.83	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V209	3.95	1	Yes	No	0	5	0	1
R:R:G106	R:R:S105	3.71	0	No	No	4	4	2	1
R:R:L112	R:R:R120	3.64	0	No	Yes	5	6	2	1
R:R:A293	R:R:V194	3.39	0	No	Yes	4	4	2	1
R:R:F291	R:R:K34	2.48	0	No	Yes	1	6	2	1
R:R:L104	R:R:R120	2.43	0	No	Yes	4	6	2	1
R:R:E121	R:R:G122	1.64	1	Yes	No	5	6	1	2
R:R:T208	R:R:V209	1.59	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TD4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.22
Number of Linked Nodes	278
Number of Links	310
Number of Hubs	37
Number of Links mediated by Hubs	151
Number of Communities	4
Number of Nodes involved in Communities	46
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	83008
Length Of Smallest Path	3
Average Path Length	13.3033
Length of Longest Path	27
Minimum Path Strength	1.145
Average Path Strength	6.77833
Maximum Path Strength	20.69
Minimum Path Correlation	0.7
Average Path Correlation	0.937169
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	61.0555
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.4737
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • synapse • cell junction • intracellular anatomical structure • cytoplasm • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • GTPase activating protein binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein localization to postsynaptic specialization membrane • protein localization to postsynaptic membrane • protein localization to cell periphery • cellular localization • protein localization to synapse • biological regulation • localization within membrane • protein localization to membrane • protein-containing complex localization • neurotransmitter receptor localization to postsynaptic specialization membrane • localization • regulation of postsynaptic membrane neurotransmitter receptor levels • macromolecule localization • protein localization to organelle • cellular process • protein localization to postsynapse • intracellular protein localization • regulation of biological quality • protein localization to cell junction • receptor localization to synapse • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • trans-synaptic signaling • regulation of signaling • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of biological process • cell-cell signaling • negative regulation of synaptic transmission • negative regulation of cell communication • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of cellular process • regulation of cell communication • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cell cortex • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • glutamatergic synapse • postsynapse • nucleus • intracellular membrane-bounded organelle • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • sphingolipid binding • lipid binding • bioactive lipid receptor activity • sphingosine-1-phosphate receptor activity • developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • cell adhesion • regulation of cell adhesion • lamellipodium assembly • plasma membrane bounded cell projection organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component biogenesis • cellular component assembly • lamellipodium organization • cell projection assembly • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of actin filament-based process • regulation of actin filament bundle assembly • actin filament bundle organization • actin filament-based process • stress fiber assembly • negative regulation of supramolecular fiber organization • regulation of actin filament organization • negative regulation of stress fiber assembly • actin cytoskeleton organization • actomyosin structure organization • negative regulation of cellular component organization • negative regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • negative regulation of actin filament bundle assembly • regulation of stress fiber assembly • negative regulation of organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cell population proliferation • heart trabecula morphogenesis • trabecula morphogenesis • cellular developmental process • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • homeostatic process • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • regulation of multicellular organismal process • regulation of multicellular organismal development • regulation of developmental process • bone mineralization • regulation of biomineral tissue development • regulation of bone mineralization • ossification • biomineral tissue development • regulation of ossification • chemotaxis • taxis • response to external stimulus • locomotion • positive chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of positive chemotaxis • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • regulation of positive chemotaxis • positive regulation of response to external stimulus • regulation of response to stimulus • regulation of locomotion • system process • nervous system process • transmission of nerve impulse • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • developmental growth • heart morphogenesis • organ growth • striated muscle tissue development • muscle structure development • cardiac muscle tissue growth involved in heart morphogenesis • animal organ morphogenesis • cardiac muscle tissue growth • muscle tissue development • muscle organ development • heart development • heart growth • cardiac muscle tissue development • growth • muscle tissue morphogenesis • developmental growth involved in morphogenesis • tissue morphogenesis • cardiac muscle tissue morphogenesis • growth involved in heart morphogenesis • muscle organ morphogenesis • cell chemotaxis • leukocyte chemotaxis • sphingolipid mediated signaling pathway • sphingosine-1-phosphate receptor signaling pathway • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • blood vessel maturation • developmental maturation • anatomical structure maturation • cell surface • external side of plasma membrane • membrane microdomain • membrane raft • presynapse • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • vesicle
SCOP2	Domain Identifier	• WD40 repeat-like • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• WD40 repeat-like • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J8C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	J8C
Name	Siponimod
Synonyms	Siponimod fumarate Siponimod
Identifier
Formula	C29 H35 F3 N2 O3
Molecular Weight	516.595
SMILES
PubChem	72959169
Formal Charge	0
Total Atoms	72
Total Chiral Atoms	0
Total Bonds	75
Total Aromatic Bonds	12


Code	NAG
PDB Residues	H:H:?1
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7TD4_nogp_Chain_R D Y V N Y D I I V R H Y N Y T G K L N I K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K M K L H N G S N N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F R K S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	doi.org/10.7554/eLife.88204
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-	Gi1/β1/γ2	2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-		2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-		2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published

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