psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N101	6.69	Yes	No	1	0	5
2	L:L:?1	R:R:E121	12	Yes	No	1	0	5
3	L:L:?1	R:R:M124	3.94	Yes	Yes	1	0	6
4	L:L:?1	R:R:F125	22.05	Yes	No	1	0	5
5	L:L:?1	R:R:L128	12.53	Yes	No	1	0	6
6	L:L:?1	R:R:S129	3.14	Yes	Yes	0	0	6
7	L:L:?1	R:R:V132	4.15	Yes	No	0	0	7
8	L:L:?1	R:R:L195	16.38	Yes	No	0	0	3
9	L:L:?1	R:R:F210	10.18	Yes	No	1	0	7
10	L:L:?1	R:R:W269	5.55	Yes	Yes	1	0	8
11	L:L:?1	R:R:L272	2.89	Yes	No	1	0	6
12	L:L:?1	R:R:L276	8.67	Yes	Yes	1	0	6
13	L:L:?1	R:R:L297	8.67	Yes	No	0	0	5
14	R:R:I25	R:R:P114	3.39	No	No	0	4	3
15	R:R:I25	R:R:L197	2.85	No	Yes	0	4	4
16	R:R:R27	R:R:V26	2.62	No	No	0	3	6
17	R:R:H28	R:R:T32	2.74	Yes	No	1	8	8
18	R:R:H28	R:R:L188	6.43	Yes	No	0	8	2
19	R:R:C191	R:R:H28	7.37	No	Yes	0	9	8
20	R:R:H28	R:R:P196	4.58	Yes	No	1	8	3
21	R:R:H28	R:R:L197	7.71	Yes	Yes	1	8	4
22	R:R:K34	R:R:Y29	4.78	No	Yes	0	6	7
23	R:R:T109	R:R:Y29	2.5	No	Yes	0	5	7
24	R:R:W117	R:R:Y29	6.75	Yes	Yes	0	9	7
25	R:R:P196	R:R:Y29	15.3	No	Yes	0	3	7
26	R:R:S189	R:R:Y31	3.82	No	No	0	4	5
27	R:R:P196	R:R:T32	5.25	No	No	1	3	8
28	R:R:G33	R:R:K285	3.49	No	No	0	7	2
29	R:R:L102	R:R:S49	9.01	Yes	No	0	5	5
30	R:R:F52	R:R:V51	2.62	Yes	No	0	6	5
31	R:R:F52	R:R:Y98	5.16	Yes	Yes	0	6	6
32	R:R:F52	R:R:V298	5.24	Yes	No	0	6	5
33	R:R:I53	R:R:L102	2.85	No	Yes	0	3	5
34	R:R:I55	R:R:I59	2.94	No	No	0	6	7
35	R:R:C56	R:R:Y98	2.69	No	Yes	0	5	6
36	R:R:C56	R:R:T99	3.38	No	No	0	5	6
37	R:R:E62	R:R:I59	4.1	Yes	No	4	8	7
38	R:R:G305	R:R:I59	5.29	No	No	4	7	7
39	R:R:I60	R:R:L92	5.71	No	No	0	6	6
40	R:R:F65	R:R:L61	7.31	No	No	0	7	4
41	R:R:E62	R:R:G305	3.27	Yes	No	4	8	7
42	R:R:E62	R:R:I309	2.73	Yes	No	0	8	6
43	R:R:D91	R:R:N63	6.73	Yes	No	5	9	9
44	R:R:L92	R:R:N63	2.75	No	No	0	6	9
45	R:R:N63	R:R:P308	4.89	No	No	5	9	9
46	R:R:I64	R:R:L68	2.85	No	No	0	4	4
47	R:R:F322	R:R:F65	3.22	No	No	0	7	7
48	R:R:I70	R:R:V66	3.07	Yes	No	0	7	9
49	R:R:A88	R:R:L67	3.15	No	No	0	9	8
50	R:R:F322	R:R:T69	7.78	No	No	0	7	8
51	R:R:I70	R:R:I84	2.94	Yes	No	0	7	8
52	R:R:I70	R:R:M318	2.92	Yes	Yes	0	7	8
53	R:R:K72	R:R:W71	4.64	No	No	0	6	3
54	R:R:I325	R:R:K72	2.91	No	No	0	6	6
55	R:R:K75	R:R:T73	4.5	No	No	2	6	6
56	R:R:F76	R:R:T73	9.08	Yes	No	2	8	6
57	R:R:H77	R:R:K74	3.93	No	No	0	7	6
58	R:R:F76	R:R:K75	2.48	Yes	No	2	8	6
59	R:R:F76	R:R:Y81	19.6	Yes	Yes	2	8	9
60	R:R:E317	R:R:F76	5.83	Yes	Yes	2	7	8
61	R:R:A321	R:R:F76	2.77	No	Yes	0	7	8
62	R:R:H77	R:R:Y82	3.27	No	No	0	7	4
63	R:R:P79	R:R:R78	2.88	No	Yes	0	7	7
64	R:R:M80	R:R:R78	3.72	Yes	Yes	0	8	7
65	R:R:R78	R:R:Y81	10.29	Yes	Yes	2	7	9
66	R:R:E317	R:R:R78	4.65	Yes	Yes	2	7	7
67	R:R:L160	R:R:P79	8.21	Yes	No	0	7	7
68	R:R:I84	R:R:M80	2.92	No	Yes	0	8	8
69	R:R:E141	R:R:M80	10.83	No	Yes	0	9	8
70	R:R:M80	R:R:R142	2.48	Yes	No	0	8	9
71	R:R:N315	R:R:Y81	4.65	No	Yes	2	8	9
72	R:R:E317	R:R:Y81	10.1	Yes	Yes	2	7	9
73	R:R:M318	R:R:Y81	9.58	Yes	Yes	2	8	9
74	R:R:L160	R:R:Y82	4.69	Yes	No	0	7	4
75	R:R:A137	R:R:F83	2.77	No	Yes	0	7	8
76	R:R:F83	R:R:I138	3.77	Yes	Yes	0	8	8
77	R:R:E141	R:R:F83	8.16	No	Yes	0	9	8
78	R:R:F83	R:R:L160	4.87	Yes	Yes	0	8	7
79	R:R:F83	R:R:L163	4.87	Yes	No	0	8	6
80	R:R:N86	R:R:W168	6.78	No	Yes	0	9	9
81	R:R:D91	R:R:L87	4.07	Yes	Yes	0	9	9
82	R:R:L87	R:R:S134	7.51	Yes	No	0	9	8
83	R:R:L135	R:R:L87	4.15	No	Yes	0	9	9
84	R:R:I138	R:R:L87	2.85	Yes	Yes	0	8	9
85	R:R:S131	R:R:S90	3.26	No	No	0	9	8
86	R:R:S90	R:R:W168	2.47	No	Yes	0	8	9
87	R:R:D91	R:R:S131	2.94	Yes	No	0	9	9
88	R:R:D91	R:R:S304	8.83	Yes	No	0	9	9
89	R:R:D91	R:R:P308	4.83	Yes	No	5	9	9
90	R:R:M124	R:R:Y98	3.59	Yes	Yes	0	6	6
91	R:R:V301	R:R:Y98	10.09	No	Yes	0	7	6
92	R:R:N101	R:R:R120	12.05	No	Yes	0	5	6
93	R:R:M124	R:R:N101	4.21	Yes	No	1	6	5
94	R:R:L102	R:R:S105	3	Yes	No	0	5	4
95	R:R:L104	R:R:L112	2.77	No	No	0	4	5
96	R:R:L104	R:R:R120	6.07	No	Yes	0	4	6
97	R:R:T109	R:R:Y110	8.74	No	No	0	5	5
98	R:R:R120	R:R:T109	2.59	Yes	No	0	6	5
99	R:R:K111	R:R:Y110	3.58	No	No	0	1	5
100	R:R:L112	R:R:Q116	11.98	No	No	0	5	4
101	R:R:P114	R:R:T113	5.25	No	No	0	3	7
102	R:R:Q116	R:R:T113	8.5	No	No	0	4	7
103	R:R:F118	R:R:W117	4.01	Yes	Yes	1	6	9
104	R:R:R120	R:R:W117	7	Yes	Yes	0	6	9
105	R:R:E121	R:R:W117	14.17	No	Yes	1	5	9
106	R:R:L197	R:R:W117	6.83	Yes	Yes	1	4	9
107	R:R:W117	R:R:Y198	3.86	Yes	Yes	1	9	4
108	R:R:F118	R:R:N183	10.87	Yes	No	1	6	5
109	R:R:F118	R:R:I185	2.51	Yes	No	1	6	3
110	R:R:F118	R:R:L197	6.09	Yes	Yes	1	6	4
111	R:R:E121	R:R:Y198	5.61	No	Yes	1	5	4
112	R:R:F125	R:R:Y202	4.13	No	Yes	1	5	7
113	R:R:C206	R:R:F125	2.79	Yes	No	1	6	5
114	R:R:L128	R:R:W269	5.69	No	Yes	1	6	8
115	R:R:F133	R:R:S129	3.96	Yes	Yes	0	5	6
116	R:R:S129	R:R:S171	3.26	Yes	No	0	6	8
117	R:R:L174	R:R:S129	3	No	Yes	0	5	6
118	R:R:A130	R:R:W168	3.89	No	Yes	7	7	9
119	R:R:A130	R:R:S171	3.42	No	No	7	7	8
120	R:R:L213	R:R:V132	2.98	No	No	0	8	7
121	R:R:C167	R:R:F133	2.79	No	Yes	0	6	5
122	R:R:F133	R:R:I170	8.79	Yes	No	0	5	4
123	R:R:F133	R:R:L213	8.53	Yes	No	0	5	8
124	R:R:L135	R:R:Y311	3.52	No	Yes	0	9	9
125	R:R:I140	R:R:L136	5.71	No	No	0	6	7
126	R:R:L136	R:R:S216	3	No	No	0	7	6
127	R:R:I217	R:R:L136	4.28	No	No	0	8	7
128	R:R:I138	R:R:R142	2.51	Yes	No	6	8	9
129	R:R:I138	R:R:Y311	3.63	Yes	Yes	6	8	9
130	R:R:A139	R:R:Y221	4	No	Yes	0	8	9
131	R:R:I140	R:R:L220	2.85	No	No	0	6	7
132	R:R:E141	R:R:T145	4.23	No	No	0	9	8
133	R:R:R142	R:R:Y311	5.14	No	Yes	6	9	9
134	R:R:L147	R:R:Y143	3.52	No	No	0	6	8
135	R:R:L220	R:R:Y143	10.55	No	No	0	7	8
136	R:R:I224	R:R:Y143	6.04	No	No	0	9	8
137	R:R:M146	R:R:V228	3.04	No	No	0	8	8
138	R:R:K148	R:R:K150	2.87	No	No	0	6	7
139	R:R:M149	R:R:R231	7.44	No	No	0	8	7
140	R:R:K150	R:R:S155	4.59	No	No	0	7	7
141	R:R:H152	R:R:N153	5.1	No	No	0	7	4
142	R:R:N156	R:R:S155	4.47	No	No	0	7	7
143	R:R:F158	R:R:N156	6.04	No	No	8	4	7
144	R:R:N156	R:R:R159	3.62	No	No	8	7	5
145	R:R:L160	R:R:N157	2.75	Yes	No	0	7	1
146	R:R:F158	R:R:R159	4.28	No	No	8	4	5
147	R:R:I164	R:R:L160	4.28	No	Yes	0	7	7
148	R:R:C167	R:R:W168	7.84	No	Yes	0	6	9
149	R:R:S171	R:R:W168	2.47	No	Yes	7	8	9
150	R:R:L174	R:R:Y202	3.52	No	Yes	1	5	7
151	R:R:C206	R:R:L174	4.76	Yes	No	1	6	5
152	R:R:L177	R:R:P178	4.93	No	Yes	0	5	5
153	R:R:L177	R:R:W182	3.42	No	No	0	5	5
154	R:R:P178	R:R:Y198	2.78	Yes	Yes	1	5	4
155	R:R:P178	R:R:Y202	11.13	Yes	Yes	1	5	7
156	R:R:I179	R:R:N183	2.83	No	No	0	5	5
157	R:R:G181	R:R:M180	3.49	No	No	0	5	4
158	R:R:H199	R:R:W182	6.35	No	No	0	4	5
159	R:R:W182	R:R:Y202	5.79	No	Yes	0	5	7
160	R:R:I185	R:R:N183	7.08	No	No	1	3	5
161	R:R:C184	R:R:C191	7.28	No	No	0	5	9
162	R:R:H199	R:R:S190	5.58	No	No	0	4	4
163	R:R:D279	R:R:T193	14.45	No	No	3	4	5
164	R:R:L290	R:R:T193	2.95	Yes	No	3	3	5
165	R:R:L195	R:R:V194	10.43	No	Yes	0	3	4
166	R:R:D279	R:R:V194	5.84	No	Yes	3	4	4
167	R:R:L290	R:R:V194	2.98	Yes	Yes	3	3	4
168	R:R:Y198	R:R:Y202	3.97	Yes	Yes	1	4	7
169	R:R:H199	R:R:H201	10.75	No	No	0	4	4
170	R:R:C206	R:R:Y202	6.72	Yes	Yes	1	6	7
171	R:R:I203	R:R:L276	4.28	No	Yes	0	6	6
172	R:R:I203	R:R:V280	3.07	No	No	0	6	4
173	R:R:L204	R:R:V280	2.98	No	No	0	5	4
174	R:R:L276	R:R:T207	4.42	Yes	No	0	6	5
175	R:R:F210	R:R:W269	10.02	No	Yes	1	7	8
176	R:R:F210	R:R:F273	7.5	No	No	0	7	6
177	R:R:F273	R:R:T211	5.19	No	No	0	6	4
178	R:R:I266	R:R:L214	2.85	No	No	0	6	5
179	R:R:V261	R:R:Y221	5.05	No	Yes	0	8	9
180	R:R:L262	R:R:Y221	3.52	No	Yes	0	7	9
181	R:R:R223	R:R:S226	5.27	No	No	0	5	3
182	R:R:L227	R:R:R223	3.64	No	No	0	6	5
183	R:R:R229	R:R:Y225	9.26	No	Yes	0	5	6
184	R:R:S251	R:R:Y225	3.82	No	Yes	0	7	6
185	R:R:L254	R:R:Y225	5.86	No	Yes	0	8	6
186	R:R:L255	R:R:Y225	10.55	No	Yes	0	8	6
187	R:R:L254	R:R:V228	4.47	No	No	0	8	8
188	R:R:R229	R:R:R233	4.26	No	No	0	5	4
189	R:R:S232	R:R:T236	3.2	No	No	0	5	4
190	R:R:L235	R:R:R234	6.07	No	No	0	6	4
191	R:R:T257	R:R:T314	4.71	No	No	0	9	7
192	R:R:I310	R:R:V264	4.61	No	No	0	8	7
193	R:R:F265	R:R:W269	4.01	No	Yes	0	9	8
194	R:R:C268	R:R:N303	6.3	No	No	0	8	9
195	R:R:N303	R:R:W269	10.17	No	Yes	0	9	8
196	R:R:L299	R:R:P271	4.93	No	No	0	7	9
197	R:R:L272	R:R:L276	2.77	No	Yes	1	6	6
198	R:R:F273	R:R:L277	4.87	No	No	0	6	6
199	R:R:L275	R:R:L290	6.92	No	Yes	0	4	3
200	R:R:F296	R:R:L275	9.74	No	No	0	4	4
201	R:R:C282	R:R:L278	6.35	No	Yes	3	4	4
202	R:R:C287	R:R:L278	3.17	No	Yes	3	3	4
203	R:R:L278	R:R:L290	2.77	Yes	Yes	3	4	3
204	R:R:D279	R:R:L290	10.86	No	Yes	3	4	3
205	R:R:C282	R:R:C287	7.28	No	No	3	4	3
206	R:R:R292	R:R:Y295	8.23	No	No	0	4	3
207	R:R:N303	R:R:N307	10.9	No	No	0	9	9
208	R:R:I309	R:R:L313	2.85	No	No	0	6	6
209	R:R:L313	R:R:T312	2.95	No	No	0	6	7
210	R:R:M318	R:R:T312	6.02	Yes	No	0	8	7
211	R:R:N315	R:R:T314	4.39	No	No	0	8	7
212	R:R:M318	R:R:N315	11.22	Yes	No	2	8	8
213	R:R:K316	R:R:R319	11.14	No	No	0	6	8
214	R:R:F52	R:R:L102	2.44	Yes	Yes	0	6	5
215	R:R:F158	R:R:L162	2.44	No	No	0	4	3
216	R:R:F265	R:R:L214	2.44	No	No	0	9	5
217	R:R:L163	R:R:R159	2.43	No	No	0	6	5
218	R:R:I217	R:R:Y221	2.42	No	Yes	0	8	9
219	R:R:D288	R:R:F291	2.39	No	No	0	3	1
220	R:R:L93	R:R:W168	2.28	No	Yes	0	6	9
221	R:R:E294	R:R:Y295	2.24	No	No	0	3	3
222	R:R:G175	R:R:G176	2.11	No	No	0	6	4
223	R:R:G176	R:R:P178	2.03	No	Yes	0	4	5
224	R:R:Y221	R:R:Y311	1.99	Yes	Yes	0	9	9
225	R:R:A88	R:R:G85	1.95	No	No	0	9	5
226	R:R:A270	R:R:P271	1.87	No	No	0	6	9
227	R:R:G106	R:R:S105	1.86	No	No	0	4	4
228	R:R:G154	R:R:S155	1.86	No	No	0	4	7
229	R:R:G175	R:R:V126	1.84	No	No	0	6	5
230	R:R:A127	R:R:A94	1.79	No	No	0	6	8
231	R:R:G85	R:R:I70	1.76	No	Yes	0	5	7
232	R:R:G106	R:R:K46	1.74	No	No	0	4	4
233	R:R:A94	R:R:S304	1.71	No	No	0	8	9
234	R:R:A97	R:R:S123	1.71	No	No	0	4	4
235	R:R:A187	R:R:S190	1.71	No	No	0	4	4
236	R:R:C222	R:R:V218	1.71	No	No	0	3	4
237	R:R:G154	R:R:N153	1.7	No	No	0	4	4
238	R:R:A293	R:R:V194	1.7	No	Yes	0	4	4
239	R:R:C287	R:R:T286	1.69	No	No	0	3	1
240	R:R:A115	R:R:T113	1.68	No	No	0	2	7
241	R:R:C57	R:R:I53	1.64	No	No	0	5	3
242	R:R:S192	R:R:V194	1.62	No	Yes	0	4	4
243	R:R:A97	R:R:M124	1.61	No	Yes	0	4	6
244	R:R:T193	R:R:V284	1.59	No	No	0	5	1
245	R:R:T306	R:R:V264	1.59	No	No	0	5	7
246	R:R:T207	R:R:T208	1.57	No	No	0	5	4
247	R:R:I60	R:R:V96	1.54	No	No	0	6	5
248	R:R:I173	R:R:V169	1.54	No	No	0	4	4
249	R:R:I266	R:R:V218	1.54	No	No	0	6	4
250	R:R:I310	R:R:V261	1.54	No	No	0	8	8
251	R:R:I325	R:R:T73	1.52	No	No	0	6	6
252	R:R:K200	R:R:V280	1.52	No	No	0	3	4
253	R:R:K200	R:R:V284	1.52	No	No	0	3	1
254	R:R:K111	R:R:T108	1.5	No	No	0	1	4
255	R:R:K283	R:R:T286	1.5	No	No	0	1	1
256	R:R:L172	R:R:V126	1.49	No	No	0	4	5
257	R:R:L254	R:R:V258	1.49	No	No	0	8	8
258	R:R:L262	R:R:V258	1.49	No	No	0	7	8
259	R:R:I24	R:R:I25	1.47	No	No	0	4	4
260	R:R:L47	R:R:T48	1.47	No	No	0	4	5
261	R:R:I140	R:R:I144	1.47	No	No	0	6	4
262	R:R:L215	R:R:T211	1.47	No	No	0	4	4
263	R:R:I259	R:R:I260	1.47	No	No	0	5	6
264	R:R:G122	R:R:Y198	1.45	No	Yes	0	6	4
265	R:R:E249	R:R:S248	1.44	No	No	0	5	4
266	R:R:I64	R:R:L67	1.43	No	No	0	4	8
267	R:R:I179	R:R:L119	1.43	No	No	0	5	4
268	R:R:I274	R:R:L277	1.43	No	No	0	5	6
269	R:R:I289	R:R:L278	1.43	No	Yes	3	3	4
270	R:R:I289	R:R:L290	1.43	No	Yes	3	3	3
271	R:R:L235	R:R:M149	1.41	No	No	0	6	8
272	R:R:D23	R:R:I24	1.4	No	No	0	7	4
273	R:R:C206	R:R:F205	1.4	Yes	No	0	6	5
274	R:R:P114	R:R:Y22	1.39	No	No	0	3	5
275	R:R:L147	R:R:L227	1.38	No	No	0	6	6
276	R:R:L299	R:R:L302	1.38	No	No	0	7	6
277	R:R:F52	R:R:T48	1.3	Yes	No	0	6	5
278	R:R:R231	R:R:T230	1.29	No	No	0	7	5
279	R:R:R234	R:R:T230	1.29	No	No	0	4	5
280	R:R:V26	R:R:Y110	1.26	No	No	0	6	5
281	R:R:F65	R:R:I64	1.26	No	No	0	7	4
282	R:R:T32	R:R:Y31	1.25	No	No	0	8	5
283	R:R:T48	R:R:Y295	1.25	No	No	0	5	3
284	R:R:F291	R:R:K34	1.24	No	No	0	1	6
285	R:R:L147	R:R:R231	1.21	No	No	0	6	7
286	R:R:E62	R:R:F58	1.17	Yes	No	0	8	4
287	R:R:E317	R:R:R320	1.16	Yes	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.98769	13	1	0
2	R:R:H28	5.766	5	1	8
3	R:R:Y29	7.3325	4	0	7
4	R:R:F52	3.352	5	0	6
5	R:R:E62	2.8175	4	4	8
6	R:R:I70	2.6725	4	0	7
7	R:R:F76	7.952	5	2	8
8	R:R:R78	5.385	4	2	7
9	R:R:M80	4.9875	4	0	8
10	R:R:Y81	10.844	5	2	9
11	R:R:F83	4.888	5	0	8
12	R:R:L87	4.645	4	0	9
13	R:R:D91	5.48	5	5	9
14	R:R:Y98	5.3825	4	0	6
15	R:R:L102	4.325	4	0	5
16	R:R:W117	7.10333	6	1	9
17	R:R:F118	5.87	4	1	6
18	R:R:R120	6.9275	4	0	6
19	R:R:M124	3.3375	4	1	6
20	R:R:S129	3.34	4	0	6
21	R:R:F133	6.0175	4	0	5
22	R:R:I138	3.19	4	6	8
23	R:R:L160	4.96	5	0	7
24	R:R:W168	4.28833	6	7	9
25	R:R:P178	5.2175	4	1	5
26	R:R:V194	4.514	5	3	4
27	R:R:L197	5.87	4	1	4
28	R:R:Y198	3.534	5	1	4
29	R:R:Y202	5.87667	6	1	7
30	R:R:C206	3.9175	4	1	6
31	R:R:Y221	3.396	5	0	9
32	R:R:Y225	7.3725	4	0	6
33	R:R:W269	7.088	5	1	8
34	R:R:L276	5.035	4	1	6
35	R:R:L278	3.43	4	3	4
36	R:R:L290	4.65167	6	3	3
37	R:R:Y311	3.57	4	6	9
38	R:R:E317	5.435	4	2	7
39	R:R:M318	7.435	4	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E121	35.0961	12	Yes	No	1	0	5
2	R:R:E121	R:R:W117	30.5024	14.17	No	Yes	1	5	9
3	R:R:L197	R:R:W117	18.98	6.83	Yes	Yes	1	4	9
4	L:L:?1	R:R:N101	12.4815	6.69	Yes	No	1	0	5
5	R:R:N101	R:R:R120	16.3895	12.05	No	Yes	0	5	6
6	R:R:W117	R:R:Y29	11.0205	6.75	Yes	Yes	0	9	7
7	L:L:?1	R:R:M124	26.1596	3.94	Yes	Yes	1	0	6
8	R:R:M124	R:R:Y98	26.8902	3.59	Yes	Yes	0	6	6
9	R:R:F52	R:R:Y98	21.4583	5.16	Yes	Yes	0	6	6
10	R:R:F52	R:R:L102	10.3482	2.44	Yes	Yes	0	6	5
11	L:L:?1	R:R:S129	84.574	3.14	Yes	Yes	0	0	6
12	R:R:S129	R:R:S171	95.7289	3.26	Yes	No	0	6	8
13	R:R:S171	R:R:W168	95.236	2.47	No	Yes	7	8	9
14	R:R:S90	R:R:W168	99.8028	2.47	No	Yes	0	8	9
15	R:R:S131	R:R:S90	99.8655	3.26	No	No	0	9	8
16	R:R:D91	R:R:S131	99.9193	2.94	Yes	No	0	9	9
17	R:R:D91	R:R:L87	100	4.07	Yes	Yes	0	9	9
18	R:R:I138	R:R:L87	75.9288	2.85	Yes	Yes	0	8	9
19	R:R:I138	R:R:R142	36.7812	2.51	Yes	No	6	8	9
20	R:R:M80	R:R:R142	44.4942	2.48	Yes	No	0	8	9
21	R:R:M80	R:R:R78	28.1271	3.72	Yes	Yes	0	8	7
22	R:R:R78	R:R:Y81	20.5486	10.29	Yes	Yes	2	7	9
23	R:R:M318	R:R:Y81	10.4827	9.58	Yes	Yes	2	8	9
24	R:R:M318	R:R:T312	16.6674	6.02	Yes	No	0	8	7
25	R:R:L313	R:R:T312	14.6148	2.95	No	No	0	6	7
26	R:R:I309	R:R:L313	12.5532	2.85	No	No	0	6	6
27	R:R:E62	R:R:I309	10.4827	2.73	Yes	No	0	8	6
28	R:R:I84	R:R:M80	20.2124	2.92	No	Yes	0	8	8
29	R:R:I70	R:R:I84	19.2668	2.94	Yes	No	0	7	8
30	R:R:G85	R:R:I70	10.2227	1.76	No	Yes	0	5	7
31	R:R:F83	R:R:I138	19.0248	3.77	Yes	Yes	0	8	8
32	R:R:F83	R:R:L163	13.9784	4.87	Yes	No	0	8	6
33	R:R:L135	R:R:L87	24.1922	4.15	No	Yes	0	9	9
34	R:R:L174	R:R:S129	13.5347	3	No	Yes	0	5	6
35	R:R:L135	R:R:Y311	23.8426	3.52	No	Yes	0	9	9
36	R:R:I138	R:R:Y311	26.8812	3.63	Yes	Yes	6	8	9
37	R:R:Y221	R:R:Y311	57.0295	1.99	Yes	Yes	0	9	9
38	R:R:I217	R:R:Y221	30.9685	2.42	No	Yes	0	8	9
39	R:R:I217	R:R:L136	29.2072	4.28	No	No	0	8	7
40	R:R:I140	R:R:L136	25.6577	5.71	No	No	0	6	7
41	R:R:I140	R:R:L220	22.0723	2.85	No	No	0	6	7
42	R:R:L220	R:R:Y143	20.2662	10.55	No	No	0	7	8
43	R:R:L147	R:R:Y143	16.6271	3.52	No	No	0	6	8
44	R:R:L262	R:R:Y221	18.0254	3.52	No	Yes	0	7	9
45	R:R:L262	R:R:V258	16.3268	1.49	No	No	0	7	8
46	R:R:L254	R:R:V258	14.4803	1.49	No	No	0	8	8
47	R:R:L163	R:R:R159	12.737	2.43	No	No	0	6	5
48	L:L:?1	R:R:L195	22.525	16.38	Yes	No	0	0	3
49	R:R:L195	R:R:V194	21.3732	10.43	No	Yes	0	3	4
50	R:R:L290	R:R:V194	14.1128	2.98	Yes	Yes	3	3	4
51	L:L:?1	R:R:L276	10.0748	8.67	Yes	Yes	1	0	6
52	L:L:?1	R:R:W269	11.6121	5.55	Yes	Yes	1	0	8
53	R:R:L174	R:R:Y202	11.2894	3.52	No	Yes	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:N101	6.69	1	Yes	No	0	5	0	1
L:L:?1	R:R:E121	12	1	Yes	No	0	5	0	1
L:L:?1	R:R:M124	3.94	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F125	22.05	1	Yes	No	0	5	0	1
L:L:?1	R:R:L128	12.53	1	Yes	No	0	6	0	1
L:L:?1	R:R:S129	3.14	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:V132	4.15	1	Yes	No	0	7	0	1
L:L:?1	R:R:L195	16.38	1	Yes	No	0	3	0	1
L:L:?1	R:R:F210	10.18	1	Yes	No	0	7	0	1
L:L:?1	R:R:W269	5.55	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L272	2.89	1	Yes	No	0	6	0	1
L:L:?1	R:R:L276	8.67	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L297	8.67	1	Yes	No	0	5	0	1
R:R:M124	R:R:Y98	3.59	1	Yes	Yes	6	6	1	2
R:R:N101	R:R:R120	12.05	1	No	Yes	5	6	1	2
R:R:M124	R:R:N101	4.21	1	Yes	No	6	5	1	1
R:R:R120	R:R:W117	7	0	Yes	Yes	6	9	2	2
R:R:E121	R:R:W117	14.17	1	No	Yes	5	9	1	2
R:R:W117	R:R:Y198	3.86	1	Yes	Yes	9	4	2	2
R:R:E121	R:R:Y198	5.61	1	No	Yes	5	4	1	2
R:R:F125	R:R:Y202	4.13	1	No	Yes	5	7	1	2
R:R:C206	R:R:F125	2.79	1	Yes	No	6	5	2	1
R:R:L128	R:R:W269	5.69	1	No	Yes	6	8	1	1
R:R:F133	R:R:S129	3.96	0	Yes	Yes	5	6	2	1
R:R:S129	R:R:S171	3.26	0	Yes	No	6	8	1	2
R:R:L174	R:R:S129	3	1	No	Yes	5	6	2	1
R:R:L213	R:R:V132	2.98	0	No	No	8	7	2	1
R:R:F133	R:R:L213	8.53	0	Yes	No	5	8	2	2
R:R:L174	R:R:Y202	3.52	1	No	Yes	5	7	2	2
R:R:C206	R:R:L174	4.76	1	Yes	No	6	5	2	2
R:R:L195	R:R:V194	10.43	0	No	Yes	3	4	1	2
R:R:Y198	R:R:Y202	3.97	1	Yes	Yes	4	7	2	2
R:R:C206	R:R:Y202	6.72	1	Yes	Yes	6	7	2	2
R:R:I203	R:R:L276	4.28	0	No	Yes	6	6	2	1
R:R:L276	R:R:T207	4.42	1	Yes	No	6	5	1	2
R:R:F210	R:R:W269	10.02	1	No	Yes	7	8	1	1
R:R:F210	R:R:F273	7.5	1	No	No	7	6	1	2
R:R:F265	R:R:W269	4.01	0	No	Yes	9	8	2	1
R:R:N303	R:R:W269	10.17	0	No	Yes	9	8	2	1
R:R:L272	R:R:L276	2.77	1	No	Yes	6	6	1	1
R:R:A97	R:R:M124	1.61	0	No	Yes	4	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EW7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.47
Number of Linked Nodes	257
Number of Links	287
Number of Hubs	39
Number of Links mediated by Hubs	149
Number of Communities	8
Number of Nodes involved in Communities	54
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	40703
Length Of Smallest Path	3
Average Path Length	13.9961
Length of Longest Path	27
Minimum Path Strength	1.25
Average Path Strength	4.68312
Maximum Path Strength	19.215
Minimum Path Correlation	0.7
Average Path Correlation	0.92323
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	49.9766
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.7363
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JEX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	JEX
Name	5-[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
Synonyms
Identifier
Formula	C20 H10 F6 N2 O S
Molecular Weight	440.362
SMILES
PubChem	4077460
Formal Charge	0
Total Atoms	40
Total Chiral Atoms	0
Total Bonds	43
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7EW7_nogp_Chain_R Y D I I V R H Y N Y T G K L K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K M K L H N G S N N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F R K S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EW7_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.