psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D23	R:R:N21	10.77	No	No	0	7	8
2	R:R:D23	R:R:Y22	5.75	No	No	0	7	5
3	R:R:I24	R:R:R27	7.52	No	No	1	4	3
4	R:R:H28	R:R:I24	5.3	Yes	No	1	8	4
5	R:R:I185	R:R:I24	2.94	Yes	No	1	3	4
6	R:R:I25	R:R:P114	5.08	No	Yes	0	4	3
7	R:R:H28	R:R:R27	5.64	Yes	No	1	8	3
8	R:R:H28	R:R:I185	2.65	Yes	Yes	1	8	3
9	R:R:H28	R:R:L188	2.57	Yes	No	0	8	2
10	R:R:C191	R:R:H28	2.95	No	Yes	0	9	8
11	R:R:H28	R:R:L197	10.29	Yes	Yes	1	8	4
12	R:R:K34	R:R:Y29	4.78	Yes	Yes	1	6	7
13	R:R:T109	R:R:Y29	12.48	Yes	Yes	1	5	7
14	R:R:W117	R:R:Y29	6.75	Yes	Yes	1	9	7
15	R:R:P196	R:R:Y29	5.56	Yes	Yes	1	3	7
16	L:L:?1	R:R:Y29	6.13	Yes	Yes	1	0	7
17	R:R:L188	R:R:Y31	15.24	No	No	0	2	5
18	R:R:K34	R:R:T32	3	Yes	No	0	6	8
19	R:R:P196	R:R:T32	5.25	Yes	No	0	3	8
20	R:R:G33	R:R:K285	3.49	No	No	0	7	2
21	R:R:F291	R:R:K34	4.96	No	Yes	0	1	6
22	L:L:?1	R:R:K34	3.68	Yes	Yes	1	0	6
23	R:R:L35	R:R:Y110	7.03	No	Yes	0	6	5
24	R:R:K46	R:R:S49	3.06	No	No	0	4	5
25	R:R:F52	R:R:T48	7.78	Yes	No	1	6	5
26	R:R:E294	R:R:T48	5.64	No	No	1	3	5
27	R:R:T48	R:R:Y295	8.74	No	No	1	5	3
28	R:R:L54	R:R:V50	2.98	No	No	0	4	5
29	R:R:F52	R:R:Y98	7.22	Yes	Yes	1	6	6
30	R:R:F52	R:R:L102	4.87	Yes	No	1	6	5
31	R:R:E294	R:R:F52	3.5	No	Yes	1	3	6
32	R:R:F52	R:R:V298	14.42	Yes	No	1	6	5
33	R:R:I55	R:R:I59	2.94	No	Yes	2	6	7
34	R:R:C56	R:R:Y98	4.03	No	Yes	0	5	6
35	R:R:C56	R:R:T99	6.76	No	No	0	5	6
36	R:R:E62	R:R:F58	15.16	No	No	0	8	4
37	R:R:I59	R:R:N63	2.83	Yes	Yes	2	7	9
38	R:R:G305	R:R:I59	5.29	No	Yes	0	7	7
39	R:R:I60	R:R:I64	2.94	No	No	0	6	4
40	R:R:I60	R:R:V96	3.07	No	No	0	6	5
41	R:R:F65	R:R:L61	12.18	No	No	0	7	4
42	R:R:E62	R:R:I309	4.1	No	No	0	8	6
43	R:R:D91	R:R:N63	6.73	Yes	Yes	2	9	9
44	R:R:N63	R:R:P308	4.89	Yes	No	2	9	9
45	R:R:I64	R:R:L92	2.85	No	No	0	4	6
46	R:R:F65	R:R:I325	7.54	No	No	0	7	6
47	R:R:I70	R:R:V66	3.07	Yes	No	0	7	9
48	R:R:F322	R:R:V66	2.62	Yes	No	0	7	9
49	R:R:A88	R:R:L67	3.15	No	No	0	9	8
50	R:R:F322	R:R:T69	16.86	Yes	No	3	7	8
51	R:R:I325	R:R:T69	6.08	No	No	3	6	8
52	R:R:I70	R:R:I84	2.94	Yes	No	0	7	8
53	R:R:I70	R:R:M318	2.92	Yes	Yes	0	7	8
54	R:R:H77	R:R:W71	3.17	No	No	4	7	3
55	R:R:W71	R:R:Y82	8.68	No	No	4	3	4
56	R:R:K75	R:R:T73	3	No	No	3	6	6
57	R:R:F76	R:R:T73	15.56	Yes	No	3	8	6
58	R:R:H77	R:R:K74	3.93	No	No	0	7	6
59	R:R:F76	R:R:K75	3.72	Yes	No	3	8	6
60	R:R:F76	R:R:Y81	18.57	Yes	No	3	8	9
61	R:R:E317	R:R:F76	4.66	No	Yes	0	7	8
62	R:R:F76	R:R:M318	3.73	Yes	Yes	3	8	8
63	R:R:A321	R:R:F76	2.77	No	Yes	0	7	8
64	R:R:H77	R:R:Y82	4.36	No	No	4	7	4
65	R:R:R78	R:R:Y81	6.17	No	No	0	7	9
66	R:R:E141	R:R:M80	4.06	No	No	0	9	8
67	R:R:M80	R:R:R142	2.48	No	Yes	0	8	9
68	R:R:M318	R:R:Y81	3.59	Yes	No	3	8	9
69	R:R:A137	R:R:F83	2.77	No	Yes	0	7	8
70	R:R:F83	R:R:I138	2.51	Yes	Yes	0	8	8
71	R:R:E141	R:R:F83	5.83	No	Yes	0	9	8
72	R:R:F83	R:R:L160	3.65	Yes	No	0	8	7
73	R:R:F83	R:R:L163	3.65	Yes	No	0	8	6
74	R:R:I138	R:R:I84	2.94	Yes	No	0	8	8
75	R:R:N86	R:R:S134	5.96	No	No	0	9	8
76	R:R:N86	R:R:W168	3.39	No	Yes	0	9	9
77	R:R:D91	R:R:L87	4.07	Yes	Yes	0	9	9
78	R:R:L87	R:R:S134	3	Yes	No	0	9	8
79	R:R:L135	R:R:L87	5.54	No	Yes	0	9	9
80	R:R:I138	R:R:L87	4.28	Yes	Yes	0	8	9
81	R:R:S134	R:R:S90	3.26	No	No	0	8	8
82	R:R:D91	R:R:S131	2.94	Yes	No	0	9	9
83	R:R:D91	R:R:S304	8.83	Yes	No	0	9	9
84	R:R:D91	R:R:N307	5.39	Yes	No	2	9	9
85	R:R:D91	R:R:P308	3.22	Yes	No	2	9	9
86	R:R:L93	R:R:W168	3.42	No	Yes	0	6	9
87	R:R:L102	R:R:Y98	12.89	No	Yes	1	5	6
88	R:R:M124	R:R:Y98	8.38	Yes	Yes	1	6	6
89	R:R:L297	R:R:Y98	4.69	No	Yes	0	5	6
90	R:R:V298	R:R:Y98	2.52	No	Yes	1	5	6
91	R:R:V301	R:R:Y98	13.88	No	Yes	0	7	6
92	R:R:N101	R:R:R120	7.23	No	Yes	1	5	6
93	R:R:M124	R:R:N101	7.01	Yes	No	1	6	5
94	L:L:?1	R:R:N101	5.98	Yes	No	1	0	5
95	R:R:G106	R:R:S105	3.71	No	No	0	4	4
96	L:L:?1	R:R:S105	5.23	Yes	No	0	0	4
97	R:R:A107	R:R:Y110	4	No	Yes	1	4	5
98	R:R:A107	R:R:K111	3.21	No	No	1	4	1
99	R:R:L112	R:R:T108	4.42	No	No	0	5	4
100	R:R:T109	R:R:Y110	4.99	Yes	Yes	1	5	5
101	R:R:T109	R:R:W117	3.64	Yes	Yes	1	5	9
102	R:R:R120	R:R:T109	2.59	Yes	Yes	1	6	5
103	L:L:?1	R:R:T109	8.99	Yes	Yes	1	0	5
104	R:R:K111	R:R:Y110	3.58	No	Yes	1	1	5
105	R:R:P114	R:R:T113	3.5	Yes	No	0	3	7
106	R:R:Q116	R:R:T113	4.25	No	No	0	4	7
107	R:R:F118	R:R:P114	2.89	Yes	Yes	0	6	3
108	R:R:R120	R:R:W117	9	Yes	Yes	1	6	9
109	R:R:E121	R:R:W117	5.45	Yes	Yes	1	5	9
110	R:R:P196	R:R:W117	2.7	Yes	Yes	1	3	9
111	R:R:L197	R:R:W117	9.11	Yes	Yes	1	4	9
112	R:R:F118	R:R:P178	4.33	Yes	Yes	1	6	5
113	R:R:F118	R:R:I179	5.02	Yes	No	0	6	5
114	R:R:F118	R:R:N183	6.04	Yes	No	0	6	5
115	R:R:F118	R:R:L197	3.65	Yes	Yes	1	6	4
116	R:R:F118	R:R:Y198	5.16	Yes	Yes	1	6	4
117	R:R:E121	R:R:R120	3.49	Yes	Yes	1	5	6
118	R:R:E121	R:R:L195	2.65	Yes	Yes	1	5	3
119	R:R:E121	R:R:Y198	5.61	Yes	Yes	1	5	4
120	L:L:?1	R:R:E121	9.23	Yes	Yes	1	0	5
121	R:R:L128	R:R:M124	2.83	No	Yes	1	6	6
122	L:L:?1	R:R:M124	6.16	Yes	Yes	1	0	6
123	R:R:F125	R:R:Y202	3.09	No	Yes	1	5	7
124	R:R:C206	R:R:F125	8.38	No	No	1	6	5
125	L:L:?1	R:R:F125	7.43	Yes	No	1	0	5
126	R:R:S171	R:R:V126	3.23	No	No	0	8	5
127	L:L:?1	R:R:L128	7.23	Yes	No	1	0	6
128	R:R:S129	R:R:W133	3.71	No	Yes	0	6	5
129	R:R:A130	R:R:W168	3.89	No	Yes	5	7	9
130	R:R:A130	R:R:S171	3.42	No	No	5	7	8
131	R:R:L213	R:R:V132	5.96	No	No	0	8	7
132	R:R:V132	R:R:W269	2.45	No	Yes	0	7	8
133	R:R:C167	R:R:W133	2.61	No	Yes	0	6	5
134	R:R:L213	R:R:W133	7.97	No	Yes	0	8	5
135	R:R:L135	R:R:N307	4.12	No	No	2	9	9
136	R:R:L135	R:R:Y311	3.52	No	Yes	2	9	9
137	R:R:I140	R:R:L136	7.14	No	No	0	6	7
138	R:R:L136	R:R:S216	3	No	No	0	7	6
139	R:R:I217	R:R:L136	4.28	No	No	0	8	7
140	R:R:I138	R:R:R142	5.01	Yes	Yes	0	8	9
141	R:R:I140	R:R:I144	2.94	No	No	0	6	4
142	R:R:E141	R:R:T145	2.82	No	No	0	9	8
143	R:R:R142	R:R:Y221	8.23	Yes	No	0	9	9
144	R:R:R142	R:R:Y311	6.17	Yes	Yes	0	9	9
145	R:R:L147	R:R:Y143	12.89	No	Yes	0	6	8
146	R:R:L220	R:R:Y143	4.69	No	Yes	0	7	8
147	R:R:R223	R:R:Y143	3.09	No	Yes	0	5	8
148	R:R:I224	R:R:Y143	7.25	No	Yes	0	9	8
149	R:R:L147	R:R:M149	2.83	No	No	0	6	8
150	R:R:K148	R:R:L151	4.23	No	No	0	6	4
151	R:R:L151	R:R:R231	6.07	No	No	0	4	7
152	R:R:L162	R:R:R159	3.64	No	No	0	3	5
153	R:R:L163	R:R:R159	6.07	No	No	0	6	5
154	R:R:I164	R:R:L160	2.85	No	No	0	7	7
155	R:R:C167	R:R:W168	3.92	No	Yes	0	6	9
156	R:R:S171	R:R:W168	4.94	No	Yes	5	8	9
157	R:R:L177	R:R:W182	5.69	No	No	1	5	5
158	R:R:L177	R:R:Y202	4.69	No	Yes	1	5	7
159	R:R:P178	R:R:Y198	5.56	Yes	Yes	1	5	4
160	R:R:P178	R:R:Y202	2.78	Yes	Yes	1	5	7
161	R:R:I179	R:R:M180	5.83	No	No	0	5	4
162	R:R:W182	R:R:Y202	5.79	No	Yes	1	5	7
163	R:R:I185	R:R:N183	11.33	Yes	No	0	3	5
164	R:R:C184	R:R:S190	5.16	No	No	0	5	4
165	R:R:C184	R:R:C191	7.28	No	No	0	5	9
166	R:R:I185	R:R:L197	2.85	Yes	Yes	1	3	4
167	R:R:H199	R:R:S190	5.58	No	No	0	4	4
168	R:R:I203	R:R:S192	3.1	No	No	0	6	4
169	R:R:D279	R:R:S192	2.94	Yes	No	0	4	4
170	R:R:D279	R:R:T193	4.34	Yes	No	1	4	5
171	R:R:L290	R:R:T193	5.9	Yes	No	1	3	5
172	R:R:L195	R:R:V194	2.98	Yes	No	1	3	4
173	R:R:D279	R:R:V194	8.76	Yes	No	1	4	4
174	R:R:L290	R:R:V194	2.98	Yes	No	1	3	4
175	R:R:L195	R:R:Y198	10.55	Yes	Yes	1	3	4
176	L:L:?1	R:R:L195	3.62	Yes	Yes	1	0	3
177	R:R:L197	R:R:P196	3.28	Yes	Yes	1	4	3
178	R:R:Y198	R:R:Y202	6.95	Yes	Yes	1	4	7
179	R:R:H199	R:R:H201	15.53	No	No	0	4	4
180	R:R:C206	R:R:Y202	6.72	No	Yes	1	6	7
181	R:R:I203	R:R:V280	6.14	No	No	0	6	4
182	R:R:L204	R:R:V280	7.45	No	No	0	5	4
183	R:R:F273	R:R:T207	5.19	Yes	No	0	6	5
184	R:R:L212	R:R:T208	2.95	No	No	0	5	4
185	R:R:F210	R:R:W269	12.03	No	Yes	0	7	8
186	R:R:F210	R:R:F273	7.5	No	Yes	0	7	6
187	L:L:?1	R:R:F210	6.36	Yes	No	0	0	7
188	R:R:F273	R:R:T211	5.19	Yes	No	0	6	4
189	R:R:F265	R:R:L214	7.31	No	No	0	9	5
190	R:R:I219	R:R:L215	4.28	No	No	0	4	4
191	R:R:I219	R:R:R223	2.51	No	No	0	4	5
192	R:R:L252	R:R:Y225	3.52	Yes	No	0	5	6
193	R:R:L254	R:R:Y225	5.86	No	No	0	8	6
194	R:R:L255	R:R:Y225	14.07	No	No	0	8	6
195	R:R:L227	R:R:R231	3.64	No	No	0	6	7
196	R:R:R229	R:R:T230	5.17	No	No	0	5	5
197	R:R:R229	R:R:R233	6.4	No	No	0	5	4
198	R:R:L252	R:R:S251	4.5	Yes	No	0	5	7
199	R:R:I260	R:R:K256	2.91	No	No	0	6	7
200	R:R:T257	R:R:T314	9.42	No	No	0	9	7
201	R:R:L262	R:R:V258	2.98	No	No	0	7	8
202	R:R:I260	R:R:I310	5.89	No	Yes	0	6	8
203	R:R:L262	R:R:V261	2.98	No	No	0	7	8
204	R:R:I310	R:R:V261	3.07	Yes	No	0	8	8
205	R:R:T306	R:R:V264	3.17	No	No	0	5	7
206	R:R:I310	R:R:V264	4.61	Yes	No	0	8	7
207	R:R:F265	R:R:W269	4.01	No	Yes	0	9	8
208	R:R:C268	R:R:N303	7.87	No	No	0	8	9
209	R:R:N303	R:R:W269	13.56	No	Yes	0	9	8
210	R:R:F296	R:R:P271	2.89	No	No	0	4	9
211	R:R:L299	R:R:P271	3.28	No	No	0	7	9
212	R:R:L272	R:R:L276	2.77	No	No	0	6	6
213	R:R:A300	R:R:L272	4.73	No	No	0	7	6
214	R:R:F296	R:R:L275	8.53	No	No	0	4	4
215	R:R:D279	R:R:L290	6.79	Yes	Yes	1	4	3
216	R:R:C282	R:R:T286	3.38	No	No	0	4	1
217	R:R:C282	R:R:C287	7.28	No	No	0	4	3
218	R:R:K283	R:R:T286	3	No	No	0	1	1
219	R:R:K285	R:R:V284	3.04	No	No	0	2	1
220	R:R:D288	R:R:I289	4.2	No	No	0	3	3
221	R:R:E294	R:R:Y295	3.37	No	No	1	3	3
222	L:L:?1	R:R:L297	3.62	Yes	No	0	0	5
223	R:R:N307	R:R:Y311	5.81	No	Yes	2	9	9
224	R:R:I309	R:R:L313	4.28	No	No	0	6	6
225	R:R:L313	R:R:T312	2.95	No	No	0	6	7
226	R:R:F322	R:R:T312	7.78	Yes	No	0	7	7
227	R:R:M318	R:R:N315	9.82	Yes	No	0	8	8
228	R:R:E317	R:R:R320	3.49	No	No	0	7	5
229	R:R:F322	R:R:M318	7.46	Yes	Yes	3	7	8
230	R:R:F322	R:R:I325	6.28	Yes	No	3	7	6
231	R:R:I323	R:R:R324	5.01	No	No	0	3	4
232	R:R:F205	R:R:L174	2.44	No	No	0	5	5
233	R:R:L104	R:R:R120	2.43	No	Yes	0	4	6
234	R:R:L252	R:R:R229	2.43	Yes	No	0	5	5
235	R:R:F161	R:R:N157	2.42	No	No	0	2	1
236	R:R:I217	R:R:Y221	2.42	No	No	0	8	9
237	R:R:I310	R:R:Y311	2.42	Yes	Yes	0	8	9
238	L:L:?1	R:R:L272	2.41	Yes	No	0	0	6
239	R:R:I170	R:R:W133	2.35	No	Yes	0	4	5
240	R:R:G175	R:R:G176	2.11	No	No	0	6	4
241	R:R:G176	R:R:P178	2.03	No	Yes	0	4	5
242	R:R:A88	R:R:G85	1.95	No	No	0	9	5
243	R:R:A94	R:R:G95	1.95	No	No	0	8	7
244	R:R:A270	R:R:P271	1.87	No	No	0	6	9
245	R:R:G33	R:R:T32	1.82	No	No	0	7	8
246	R:R:A127	R:R:A94	1.79	No	No	0	6	8
247	R:R:A127	R:R:A97	1.79	No	No	0	6	4
248	R:R:P114	R:R:V20	1.77	Yes	No	0	3	5
249	R:R:G85	R:R:I70	1.76	No	Yes	0	5	7
250	R:R:A94	R:R:S304	1.71	No	No	0	8	9
251	R:R:A97	R:R:S123	1.71	No	No	0	4	4
252	R:R:G175	R:R:L174	1.71	No	No	0	6	5
253	R:R:A187	R:R:S186	1.71	No	No	0	4	1
254	R:R:A187	R:R:S189	1.71	No	No	0	4	4
255	R:R:A187	R:R:S190	1.71	No	No	0	4	4
256	R:R:C222	R:R:V218	1.71	No	No	0	3	4
257	R:R:E121	R:R:G122	1.64	Yes	No	0	5	6
258	R:R:A139	R:R:I217	1.62	No	No	0	8	8
259	R:R:S165	R:R:V169	1.62	No	No	0	4	4
260	R:R:S226	R:R:T230	1.6	No	No	0	3	5
261	R:R:T257	R:R:V261	1.59	No	No	0	9	8
262	R:R:C287	R:R:L290	1.59	No	Yes	0	3	3
263	R:R:A139	R:R:L220	1.58	No	No	0	8	7
264	R:R:A293	R:R:L275	1.58	No	No	0	4	4
265	R:R:T207	R:R:T208	1.57	No	No	0	5	4
266	R:R:I55	R:R:V51	1.54	No	No	0	6	5
267	R:R:I173	R:R:V169	1.54	No	No	0	4	4
268	R:R:I53	R:R:T99	1.52	No	No	0	3	6
269	R:R:M146	R:R:V228	1.52	No	No	0	8	8
270	R:R:L252	R:R:S232	1.5	Yes	No	0	5	5
271	R:R:L35	R:R:V26	1.49	No	No	0	6	6
272	R:R:L172	R:R:V126	1.49	No	No	0	4	5
273	R:R:L213	R:R:V209	1.49	No	No	0	8	5
274	R:R:L214	R:R:V218	1.49	No	No	0	5	4
275	R:R:L262	R:R:V218	1.49	No	No	0	7	4
276	R:R:L252	R:R:V228	1.49	Yes	No	0	5	8
277	R:R:L277	R:R:V280	1.49	No	No	0	6	4
278	R:R:P79	R:R:R78	1.44	No	No	0	7	7
279	R:R:I55	R:R:L302	1.43	No	No	2	6	6
280	R:R:I59	R:R:L302	1.43	Yes	No	2	7	6
281	R:R:I259	R:R:L255	1.43	No	No	0	5	8
282	R:R:I289	R:R:L275	1.43	No	No	0	3	4
283	R:R:L67	R:R:L89	1.38	No	No	0	8	5
284	R:R:L103	R:R:L104	1.38	No	No	0	6	4
285	R:R:L147	R:R:L227	1.38	No	No	0	6	6
286	R:R:L92	R:R:N63	1.37	No	Yes	0	6	9
287	R:R:L112	R:R:Q116	1.33	No	No	0	5	4
288	R:R:F265	R:R:I266	1.26	No	No	0	9	6
289	R:R:F273	R:R:I274	1.26	Yes	No	0	6	5
290	R:R:K316	R:R:R319	1.24	No	No	0	6	8
291	R:R:F237	R:R:L235	1.22	No	No	0	3	6
292	R:R:I25	R:R:Y22	1.21	No	No	0	4	5
293	R:R:D288	R:R:F291	1.19	No	No	0	3	1
294	R:R:I70	R:R:W71	1.17	Yes	No	0	7	3
295	R:R:L160	R:R:Y82	1.17	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H28	4.9	6	1	8
2	R:R:Y29	7.14	5	1	7
3	R:R:K34	4.105	4	1	6
4	R:R:F52	7.558	5	1	6
5	R:R:I59	3.1225	4	2	7
6	R:R:N63	3.955	4	2	9
7	R:R:I70	2.372	5	0	7
8	R:R:F76	8.16833	6	3	8
9	R:R:F83	3.682	5	0	8
10	R:R:L87	4.2225	4	0	9
11	R:R:D91	5.19667	6	2	9
12	R:R:Y98	7.65857	7	1	6
13	R:R:T109	6.538	5	1	5
14	R:R:Y110	4.9	4	1	5
15	R:R:P114	3.31	4	0	3
16	R:R:W117	6.10833	6	1	9
17	R:R:F118	4.515	6	1	6
18	R:R:R120	4.948	5	1	6
19	R:R:E121	4.67833	6	1	5
20	R:R:M124	6.095	4	1	6
21	R:R:W133	4.16	4	0	5
22	R:R:I138	3.685	4	0	8
23	R:R:R142	5.4725	4	0	9
24	R:R:Y143	6.98	4	0	8
25	R:R:W168	3.912	5	5	9
26	R:R:P178	3.675	4	1	5
27	R:R:I185	4.9425	4	1	3
28	R:R:L195	4.95	4	1	3
29	R:R:P196	4.1975	4	1	3
30	R:R:L197	5.836	5	1	4
31	R:R:Y198	6.766	5	1	4
32	R:R:Y202	5.00333	6	1	7
33	R:R:L252	2.688	5	0	5
34	R:R:W269	8.0125	4	0	8
35	R:R:F273	4.785	4	0	6
36	R:R:D279	5.7075	4	1	4
37	R:R:L290	4.315	4	1	3
38	R:R:I310	3.9975	4	0	8
39	R:R:Y311	4.48	4	2	9
40	R:R:M318	5.504	5	3	8
41	R:R:F322	8.2	5	3	7
42	L:L:?1	5.85154	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F118	R:R:P114	14.7271	2.89	Yes	Yes	0	6	3
2	R:R:H28	R:R:L197	34.2155	10.29	Yes	Yes	1	8	4
3	R:R:C191	R:R:H28	21.1889	2.95	No	Yes	0	9	8
4	R:R:L197	R:R:W117	30.8888	9.11	Yes	Yes	1	4	9
5	R:R:W117	R:R:Y29	10.8615	6.75	Yes	Yes	1	9	7
6	R:R:L197	R:R:P196	11.3764	3.28	Yes	Yes	1	4	3
7	R:R:P196	R:R:Y29	10.9166	5.56	Yes	Yes	1	3	7
8	R:R:F118	R:R:Y198	18.7963	5.16	Yes	Yes	1	6	4
9	R:R:E121	R:R:Y198	12.7727	5.61	Yes	Yes	1	5	4
10	L:L:?1	R:R:E121	25.0257	9.23	Yes	Yes	1	0	5
11	L:L:?1	R:R:K34	10.3969	3.68	Yes	Yes	1	0	6
12	R:R:L195	R:R:Y198	13.7236	10.55	Yes	Yes	1	3	4
13	L:L:?1	R:R:L195	21.7996	3.62	Yes	Yes	1	0	3
14	R:R:T109	R:R:W117	10.6459	3.64	Yes	Yes	1	5	9
15	L:L:?1	R:R:M124	11.5417	6.16	Yes	Yes	1	0	6
16	R:R:M124	R:R:Y98	11.3477	8.38	Yes	Yes	1	6	6
17	L:L:?1	R:R:L297	11.6087	3.62	Yes	No	0	0	5
18	R:R:L297	R:R:Y98	10.7202	4.69	No	Yes	0	5	6
19	L:L:?1	R:R:F210	99.8898	6.36	Yes	No	0	0	7
20	R:R:F210	R:R:W269	100	12.03	No	Yes	0	7	8
21	R:R:V132	R:R:W269	44.3872	2.45	No	Yes	0	7	8
22	R:R:L213	R:R:V132	44.0663	5.96	No	No	0	8	7
23	R:R:L213	R:R:W133	43.525	7.97	No	Yes	0	8	5
24	R:R:C167	R:R:W133	42.749	2.61	No	Yes	0	6	5
25	R:R:C167	R:R:W168	42.4951	3.92	No	Yes	0	6	9
26	R:R:N86	R:R:W168	40.9288	3.39	No	Yes	0	9	9
27	R:R:N86	R:R:S134	40.6606	5.96	No	No	0	9	8
28	R:R:L87	R:R:S134	40.1193	3	Yes	No	0	9	8
29	R:R:D91	R:R:L87	13.9056	4.07	Yes	Yes	0	9	9
30	R:R:D91	R:R:N63	13.3619	6.73	Yes	Yes	2	9	9
31	R:R:F265	R:R:W269	56.2475	4.01	No	Yes	0	9	8
32	R:R:F265	R:R:L214	55.7014	7.31	No	No	0	9	5
33	R:R:L214	R:R:V218	55.4307	1.49	No	No	0	5	4
34	R:R:L262	R:R:V218	54.8847	1.49	No	No	0	7	4
35	R:R:L262	R:R:V261	54.3769	2.98	No	No	0	7	8
36	R:R:I310	R:R:V261	53.6321	3.07	Yes	No	0	8	8
37	R:R:I310	R:R:Y311	52.3028	2.42	Yes	Yes	0	8	9
38	R:R:N307	R:R:Y311	11.9129	5.81	No	Yes	2	9	9
39	R:R:D91	R:R:N307	11.4483	5.39	Yes	No	2	9	9
40	R:R:I138	R:R:L87	32.8719	4.28	Yes	Yes	0	8	9
41	R:R:I138	R:R:I84	49.3402	2.94	Yes	No	0	8	8
42	R:R:I70	R:R:I84	48.2289	2.94	Yes	No	0	7	8
43	R:R:I70	R:R:V66	13.5918	3.07	Yes	No	0	7	9
44	R:R:F322	R:R:V66	12.3823	2.62	Yes	No	0	7	9
45	R:R:F322	R:R:T312	12.5356	7.78	Yes	No	0	7	7
46	R:R:L313	R:R:T312	10.0376	2.95	No	No	0	6	7
47	R:R:R142	R:R:Y311	41.5252	6.17	Yes	Yes	0	9	9
48	R:R:I138	R:R:R142	32.5414	5.01	Yes	Yes	0	8	9
49	R:R:I70	R:R:M318	25.9263	2.92	Yes	Yes	0	7	8
50	R:R:F322	R:R:M318	12.6218	7.46	Yes	Yes	3	7	8
51	R:R:F83	R:R:I138	12.6769	2.51	Yes	Yes	0	8	8
52	R:R:R142	R:R:Y221	15.3737	8.23	Yes	No	0	9	9
53	R:R:I217	R:R:Y221	14.6121	2.42	No	No	0	8	9
54	R:R:A139	R:R:I217	10.6962	1.62	No	No	0	8	8
55	R:R:C184	R:R:C191	18.5567	7.28	No	No	0	5	9
56	R:R:C184	R:R:S190	15.9198	5.16	No	No	0	5	4
57	R:R:L195	R:R:V194	11.1657	2.98	Yes	No	1	3	4
58	L:L:?1	R:R:Y29	20.5542	6.13	Yes	Yes	1	0	7
59	L:L:?1	R:R:T109	15.8025	8.99	Yes	Yes	1	0	5
60	R:R:E121	R:R:W117	10.8088	5.45	Yes	Yes	1	5	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K34	R:R:Y29	4.78	1	Yes	Yes	6	7	1	1
R:R:T109	R:R:Y29	12.48	1	Yes	Yes	5	7	1	1
R:R:W117	R:R:Y29	6.75	1	Yes	Yes	9	7	2	1
R:R:P196	R:R:Y29	5.56	1	Yes	Yes	3	7	2	1
L:L:?1	R:R:Y29	6.13	1	Yes	Yes	0	7	0	1
R:R:K34	R:R:T32	3	1	Yes	No	6	8	1	2
R:R:P196	R:R:T32	5.25	1	Yes	No	3	8	2	2
R:R:F291	R:R:K34	4.96	0	No	Yes	1	6	2	1
L:L:?1	R:R:K34	3.68	1	Yes	Yes	0	6	0	1
R:R:M124	R:R:Y98	8.38	1	Yes	Yes	6	6	1	2
R:R:L297	R:R:Y98	4.69	0	No	Yes	5	6	1	2
R:R:N101	R:R:R120	7.23	1	No	Yes	5	6	1	2
R:R:M124	R:R:N101	7.01	1	Yes	No	6	5	1	1
L:L:?1	R:R:N101	5.98	1	Yes	No	0	5	0	1
R:R:G106	R:R:S105	3.71	0	No	No	4	4	2	1
L:L:?1	R:R:S105	5.23	1	Yes	No	0	4	0	1
R:R:T109	R:R:Y110	4.99	1	Yes	Yes	5	5	1	2
R:R:T109	R:R:W117	3.64	1	Yes	Yes	5	9	1	2
R:R:R120	R:R:T109	2.59	1	Yes	Yes	6	5	2	1
L:L:?1	R:R:T109	8.99	1	Yes	Yes	0	5	0	1
R:R:R120	R:R:W117	9	1	Yes	Yes	6	9	2	2
R:R:E121	R:R:W117	5.45	1	Yes	Yes	5	9	1	2
R:R:P196	R:R:W117	2.7	1	Yes	Yes	3	9	2	2
R:R:E121	R:R:R120	3.49	1	Yes	Yes	5	6	1	2
R:R:E121	R:R:L195	2.65	1	Yes	Yes	5	3	1	1
R:R:E121	R:R:Y198	5.61	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:E121	9.23	1	Yes	Yes	0	5	0	1
R:R:L128	R:R:M124	2.83	1	No	Yes	6	6	1	1
L:L:?1	R:R:M124	6.16	1	Yes	Yes	0	6	0	1
R:R:F125	R:R:Y202	3.09	1	No	Yes	5	7	1	2
R:R:C206	R:R:F125	8.38	1	No	No	6	5	2	1
L:L:?1	R:R:F125	7.43	1	Yes	No	0	5	0	1
L:L:?1	R:R:L128	7.23	1	Yes	No	0	6	0	1
R:R:L195	R:R:V194	2.98	1	Yes	No	3	4	1	2
R:R:L195	R:R:Y198	10.55	1	Yes	Yes	3	4	1	2
L:L:?1	R:R:L195	3.62	1	Yes	Yes	0	3	0	1
R:R:Y198	R:R:Y202	6.95	1	Yes	Yes	4	7	2	2
R:R:C206	R:R:Y202	6.72	1	No	Yes	6	7	2	2
R:R:F210	R:R:W269	12.03	0	No	Yes	7	8	1	2
R:R:F210	R:R:F273	7.5	0	No	Yes	7	6	1	2
L:L:?1	R:R:F210	6.36	1	Yes	No	0	7	0	1
R:R:L272	R:R:L276	2.77	0	No	No	6	6	1	2
R:R:A300	R:R:L272	4.73	0	No	No	7	6	2	1
L:L:?1	R:R:L297	3.62	1	Yes	No	0	5	0	1
L:L:?1	R:R:L272	2.41	1	Yes	No	0	6	0	1
R:R:E121	R:R:G122	1.64	1	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EO2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.45
Number of Linked Nodes	258
Number of Links	295
Number of Hubs	42
Number of Links mediated by Hubs	160
Number of Communities	5
Number of Nodes involved in Communities	62
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	63485
Length Of Smallest Path	3
Average Path Length	15.7144
Length of Longest Path	30
Minimum Path Strength	1.465
Average Path Strength	4.9902
Maximum Path Strength	17.065
Minimum Path Correlation	0.7
Average Path Correlation	0.941642
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	54.851
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.254
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J89
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	J89
Name	(2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol
Synonyms
Identifier
Formula	C19 H34 N O5 P
Molecular Weight	387.451
SMILES
PubChem	11452022
Formal Charge	0
Total Atoms	60
Total Chiral Atoms	1
Total Bonds	60
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7EO2_nogp_Chain_R V N Y D I I V R H Y N Y T G K L K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V W S L L A I A I E R Y I T M L K M K L H N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	doi.org/10.7554/eLife.88204
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-	Gi1/β1/γ2	2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-		2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-		2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EO2_nogp.zip

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