Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7EO2 | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | FTY720-P | - | Gi1/Beta1/Gamma2 | 2.89 | 2022-01-05 | 10.1038/s41589-021-00930-3 |
![](/psngpcr/ligands/J89/J89_7EO2_L_L_1.png)
A 2D representation of the interactions of J89 in 7EO2 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:K34 | R:R:Y29 | 4.78 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | R:R:T109 | R:R:Y29 | 12.48 | 1 | Yes | Yes | 5 | 7 | 1 | 1 | R:R:W117 | R:R:Y29 | 6.75 | 1 | Yes | Yes | 9 | 7 | 2 | 1 | R:R:P196 | R:R:Y29 | 5.56 | 1 | Yes | Yes | 3 | 7 | 2 | 1 | L:L:?1 | R:R:Y29 | 6.07 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:K34 | R:R:T32 | 3 | 1 | Yes | No | 6 | 8 | 1 | 2 | R:R:P196 | R:R:T32 | 5.25 | 1 | Yes | No | 3 | 8 | 2 | 2 | R:R:F291 | R:R:K34 | 4.96 | 0 | No | Yes | 1 | 6 | 2 | 1 | L:L:?1 | R:R:K34 | 3.65 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:M124 | R:R:Y98 | 8.38 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:L297 | R:R:Y98 | 4.69 | 0 | No | Yes | 5 | 6 | 1 | 2 | R:R:N101 | R:R:R120 | 7.23 | 1 | No | Yes | 5 | 6 | 1 | 2 | R:R:M124 | R:R:N101 | 7.01 | 1 | Yes | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:N101 | 5.93 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:G106 | R:R:S105 | 3.71 | 0 | No | No | 4 | 4 | 2 | 1 | L:L:?1 | R:R:S105 | 5.18 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:T109 | R:R:Y110 | 4.99 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:T109 | R:R:W117 | 3.64 | 1 | Yes | Yes | 5 | 9 | 1 | 2 | R:R:R120 | R:R:T109 | 2.59 | 1 | Yes | Yes | 6 | 5 | 2 | 1 | L:L:?1 | R:R:T109 | 8.9 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:R120 | R:R:W117 | 9 | 1 | Yes | Yes | 6 | 9 | 2 | 2 | R:R:E121 | R:R:W117 | 5.45 | 1 | Yes | Yes | 5 | 9 | 1 | 2 | R:R:P196 | R:R:W117 | 2.7 | 1 | Yes | Yes | 3 | 9 | 2 | 2 | R:R:E121 | R:R:R120 | 3.49 | 1 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:E121 | R:R:L195 | 2.65 | 1 | Yes | Yes | 5 | 3 | 1 | 1 | R:R:E121 | R:R:Y198 | 5.61 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | L:L:?1 | R:R:E121 | 9.15 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L128 | R:R:M124 | 2.83 | 1 | No | Yes | 6 | 6 | 1 | 1 | L:L:?1 | R:R:M124 | 6.1 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F125 | R:R:Y202 | 3.09 | 1 | No | Yes | 5 | 7 | 1 | 2 | R:R:C206 | R:R:F125 | 8.38 | 1 | No | No | 6 | 5 | 2 | 1 | L:L:?1 | R:R:F125 | 7.36 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:L128 | 7.17 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:L195 | R:R:V194 | 2.98 | 1 | Yes | No | 3 | 4 | 1 | 2 | R:R:L195 | R:R:Y198 | 10.55 | 1 | Yes | Yes | 3 | 4 | 1 | 2 | L:L:?1 | R:R:L195 | 3.58 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:Y198 | R:R:Y202 | 6.95 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | R:R:C206 | R:R:Y202 | 6.72 | 1 | No | Yes | 6 | 7 | 2 | 2 | R:R:F210 | R:R:L214 | 2.44 | 0 | Yes | No | 7 | 5 | 1 | 2 | R:R:F210 | R:R:W269 | 12.03 | 0 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F210 | R:R:F273 | 7.5 | 0 | Yes | Yes | 7 | 6 | 1 | 2 | L:L:?1 | R:R:F210 | 6.31 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:L272 | R:R:L276 | 2.77 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:A300 | R:R:L272 | 4.73 | 0 | No | No | 7 | 6 | 2 | 1 | L:L:?1 | R:R:L272 | 2.39 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:L297 | 3.58 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:E121 | R:R:G122 | 1.64 | 1 | Yes | No | 5 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 5.80 | Average Nodes In Shell | 32.00 | Average Hubs In Shell | 17.00 | Average Links In Shell | 47.00 | Average Links Mediated by Hubs In Shell | 43.00 |
| ![](/psngpcr/ligands/J89/J89_7EO2_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/J89/J89_7EO2_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7EW2 | A | Lipid | Lysophospholipid (S1P) | S1P3 | Homo sapiens | Fingolimod | - | Gi1/Beta1/Gamma2 | 3.1 | 2021-09-29 | 10.1038/s41422-021-00567-w |
![](/psngpcr/ligands/J89/J89_7EW2_L_L_1.png)
A 2D representation of the interactions of J89 in 7EW2 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:L28 | R:R:Y22 | 2.34 | 2 | Yes | Yes | 3 | 9 | 2 | 1 | R:R:T103 | R:R:Y22 | 8.74 | 2 | Yes | Yes | 5 | 9 | 1 | 1 | R:R:F104 | R:R:Y22 | 5.16 | 2 | Yes | Yes | 7 | 9 | 2 | 1 | R:R:P190 | R:R:Y22 | 11.13 | 0 | No | Yes | 4 | 9 | 2 | 1 | L:L:?1 | R:R:Y22 | 4.05 | 2 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:F104 | R:R:L28 | 3.65 | 2 | Yes | Yes | 7 | 3 | 2 | 2 | R:R:R31 | R:R:T103 | 2.59 | 2 | No | Yes | 4 | 5 | 1 | 1 | R:R:F104 | R:R:R31 | 3.21 | 2 | Yes | No | 7 | 4 | 2 | 1 | L:L:?1 | R:R:R31 | 10.48 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:N95 | R:R:Y92 | 4.65 | 2 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:M118 | R:R:Y92 | 8.38 | 2 | No | Yes | 6 | 6 | 1 | 2 | R:R:N95 | R:R:S99 | 5.96 | 2 | Yes | Yes | 6 | 5 | 1 | 1 | R:R:N95 | R:R:R114 | 4.82 | 2 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:M118 | R:R:N95 | 5.61 | 2 | No | Yes | 6 | 6 | 1 | 1 | L:L:?1 | R:R:N95 | 18.96 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:G100 | R:R:S99 | 3.71 | 0 | No | Yes | 6 | 5 | 2 | 1 | R:R:R114 | R:R:S99 | 6.59 | 2 | Yes | Yes | 6 | 5 | 1 | 1 | L:L:?1 | R:R:S99 | 15.55 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:F104 | R:R:T103 | 7.78 | 2 | Yes | Yes | 7 | 5 | 2 | 1 | L:L:?1 | R:R:T103 | 5.09 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:R114 | R:R:W111 | 8 | 2 | Yes | Yes | 6 | 9 | 1 | 2 | R:R:E115 | R:R:W111 | 5.45 | 2 | Yes | Yes | 5 | 9 | 1 | 2 | R:R:E115 | R:R:R114 | 3.49 | 2 | Yes | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:R114 | 6.29 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:E115 | R:R:L189 | 6.63 | 2 | Yes | No | 5 | 5 | 1 | 1 | R:R:E115 | R:R:Y192 | 7.86 | 2 | Yes | Yes | 5 | 3 | 1 | 2 | L:L:?1 | R:R:E115 | 6.86 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:M118 | 9.76 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F119 | R:R:Y192 | 4.13 | 2 | Yes | Yes | 5 | 3 | 1 | 2 | R:R:F119 | R:R:Y196 | 10.32 | 2 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:C200 | R:R:F119 | 2.79 | 2 | No | Yes | 6 | 5 | 2 | 1 | L:L:?1 | R:R:F119 | 4.2 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L122 | R:R:W256 | 5.69 | 0 | No | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:L122 | 8.36 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:A165 | R:R:G123 | 1.95 | 0 | No | No | 8 | 5 | 2 | 1 | R:R:F263 | R:R:I188 | 2.51 | 2 | Yes | Yes | 6 | 4 | 1 | 2 | R:R:L189 | R:R:Y192 | 8.21 | 2 | No | Yes | 5 | 3 | 1 | 2 | L:L:?1 | R:R:L189 | 4.78 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:Y192 | R:R:Y196 | 4.96 | 2 | Yes | Yes | 3 | 6 | 2 | 2 | R:R:C200 | R:R:Y196 | 2.69 | 2 | No | Yes | 6 | 6 | 2 | 2 | R:R:F263 | R:R:I197 | 2.51 | 2 | Yes | No | 6 | 6 | 1 | 2 | R:R:F260 | R:R:I201 | 5.02 | 2 | Yes | No | 6 | 4 | 1 | 2 | R:R:F263 | R:R:I201 | 2.51 | 2 | Yes | No | 6 | 4 | 1 | 2 | R:R:F204 | R:R:W256 | 4.01 | 2 | No | Yes | 7 | 8 | 2 | 2 | R:R:F204 | R:R:F260 | 38.58 | 2 | No | Yes | 7 | 6 | 2 | 1 | R:R:L259 | R:R:W256 | 2.28 | 0 | No | Yes | 6 | 8 | 2 | 2 | R:R:F260 | R:R:W256 | 6.01 | 2 | Yes | Yes | 6 | 8 | 1 | 2 | R:R:F263 | R:R:L259 | 4.87 | 2 | Yes | No | 6 | 6 | 1 | 2 | R:R:F260 | R:R:F263 | 3.22 | 2 | Yes | Yes | 6 | 6 | 1 | 1 | L:L:?1 | R:R:F260 | 4.2 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:F263 | 3.15 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:I284 | 2.46 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:F119 | R:R:G169 | 1.51 | 2 | Yes | No | 5 | 7 | 1 | 2 | L:L:?1 | R:R:G123 | 1.48 | 2 | Yes | No | 0 | 5 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 9.00 | Average Interaction Strength | 7.04 | Average Nodes In Shell | 33.00 | Average Hubs In Shell | 18.00 | Average Links In Shell | 54.00 | Average Links Mediated by Hubs In Shell | 53.00 |
| ![](/psngpcr/ligands/J89/J89_7EW2_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/J89/J89_7EW2_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7VIF | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | (S)-FTY720-P | - | Gi1/Beta1/Gamma2 | 2.83 | 2022-09-28 | 10.1073/pnas.2117716119 |
![](/psngpcr/ligands/J89/J89_7VIF_L_L_1.png)
A 2D representation of the interactions of J89 in 7VIF colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:K34 | R:R:Y29 | 8.36 | 0 | No | Yes | 6 | 7 | 2 | 1 | R:R:Y110 | R:R:Y29 | 3.97 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:W117 | R:R:Y29 | 4.82 | 2 | Yes | Yes | 9 | 7 | 2 | 1 | R:R:P196 | R:R:Y29 | 15.3 | 0 | No | Yes | 3 | 7 | 2 | 1 | L:L:?1 | R:R:Y29 | 7.08 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:N101 | R:R:Y98 | 3.49 | 2 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:M124 | R:R:Y98 | 5.99 | 2 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:N101 | R:R:R120 | 7.23 | 2 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:M124 | R:R:N101 | 11.22 | 2 | Yes | Yes | 6 | 5 | 2 | 1 | L:L:?1 | R:R:N101 | 13.04 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:S105 | 12.96 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:T109 | R:R:Y110 | 3.75 | 0 | No | No | 5 | 5 | 1 | 2 | R:R:R120 | R:R:T109 | 7.76 | 2 | Yes | No | 6 | 5 | 2 | 1 | L:L:?1 | R:R:T109 | 3.82 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:R120 | R:R:W117 | 8 | 2 | Yes | Yes | 6 | 9 | 2 | 2 | R:R:E121 | R:R:W117 | 22.9 | 2 | Yes | Yes | 5 | 9 | 1 | 2 | R:R:L195 | R:R:W117 | 4.56 | 2 | Yes | Yes | 3 | 9 | 2 | 2 | R:R:W117 | R:R:Y198 | 4.82 | 2 | Yes | Yes | 9 | 4 | 2 | 2 | R:R:E121 | R:R:R120 | 5.82 | 2 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:E121 | R:R:L195 | 3.98 | 2 | Yes | Yes | 5 | 3 | 1 | 2 | R:R:E121 | R:R:Y198 | 3.37 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | L:L:?1 | R:R:E121 | 8.01 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L297 | R:R:M124 | 4.24 | 0 | No | Yes | 5 | 6 | 1 | 2 | R:R:F125 | R:R:Y198 | 9.28 | 0 | No | Yes | 5 | 4 | 1 | 2 | L:L:?1 | R:R:F125 | 14.72 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:L128 | R:R:W269 | 6.83 | 2 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:L128 | 8.36 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:S129 | R:R:S171 | 3.26 | 0 | No | No | 6 | 8 | 1 | 2 | R:R:L174 | R:R:S129 | 4.5 | 0 | No | No | 5 | 6 | 2 | 1 | L:L:?1 | R:R:S129 | 5.18 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F265 | R:R:V132 | 3.93 | 2 | Yes | No | 9 | 7 | 2 | 2 | R:R:V132 | R:R:W269 | 3.68 | 2 | No | Yes | 7 | 8 | 2 | 1 | R:R:L195 | R:R:Y198 | 9.38 | 2 | Yes | Yes | 3 | 4 | 2 | 2 | R:R:F210 | R:R:W269 | 12.03 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:F265 | R:R:W269 | 8.02 | 2 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F265 | R:R:N303 | 6.04 | 2 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:L272 | R:R:W269 | 5.69 | 2 | No | Yes | 6 | 8 | 1 | 1 | R:R:N303 | R:R:W269 | 6.78 | 2 | Yes | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W269 | 5.9 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:L272 | 8.36 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:L297 | 11.95 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:A300 | R:R:W269 | 2.59 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:G106 | R:R:S105 | 1.86 | 0 | No | No | 4 | 4 | 2 | 1 | R:R:F125 | R:R:G122 | 1.51 | 0 | No | No | 5 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 9.03 | Average Nodes In Shell | 30.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 44.00 | Average Links Mediated by Hubs In Shell | 39.00 |
| ![](/psngpcr/ligands/J89/J89_7VIF_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/J89/J89_7VIF_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|