Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.04565
2A:A:L38 4.5425468
3A:A:K46 3.83469
4A:A:Q52 5.025409
5A:A:F191 5.024565
6A:A:F196 6.21571767
7A:A:K197 8.2025416
8A:A:M198 3.8725467
9A:A:F199 8.314515
10A:A:Q204 5.875419
11A:A:S206 4.52418
12A:A:R208 4.21409
13A:A:K210 5.41571719
14A:A:W211 4.905619
15A:A:I212 2.865418
16A:A:C214 3.4975417
17A:A:F215 5.938519
18A:A:I221 4.72418
19A:A:Y230 6.9748
20A:A:D231 10.2775449
21A:A:N241 5.6075409
22A:A:F250 6.463336129
23A:A:I253 4.0425418
24A:A:C254 4.75125
25A:A:W258 5.57429715
26A:A:F259 6.19833619
27A:A:I264 4.324126
28A:A:I265 2.892508
29A:A:F267 4.34754159
30A:A:N269 5.4575409
31A:A:F274 4.16333649
32A:A:K277 4.24449
33A:A:I278 4.2875446
34A:A:L283 4.902547
35A:A:C286 6.2425446
36A:A:Y287 6.235647
37A:A:Y290 9.3225407
38A:A:Y296 3.41444
39A:A:F307 3.532508
40A:A:N311 6.154128
41A:A:E318 8.832574
42A:A:I319 4.994125
43A:A:Y320 6.63333677
44A:A:F323 3.23333644
45A:A:N331 6.114158
46A:A:F336 4.92833668
47A:A:D341 7.6275478
48B:B:L14 6.2408
49B:B:R48 4.405437
50B:B:R49 4.4875407
51B:B:L51 8.482539
52B:B:H54 8.406509
53B:B:Y59 7.1025418
54B:B:W63 5.88429737
55B:B:R68 8.67535
56B:B:L70 6.375435
57B:B:D76 5.395409
58B:B:K78 3.976508
59B:B:I81 4.2075407
60B:B:W82 11639
61B:B:S84 3.85435
62B:B:Y85 11.14434
63B:B:N88 4.39537
64B:B:K89 6.97333639
65B:B:H91 4.645405
66B:B:L95 3.47588
67B:B:W99 6.59286719
68B:B:Y105 3.436506
69B:B:Y111 5.24614
70B:B:C114 2.7475488
71B:B:L117 4.1125419
72B:B:I123 3.565416
73B:B:Y124 3.53667686
74B:B:T128 3.53254193
75B:B:V133 4.69484
76B:B:R137 2.915405
77B:B:H142 6.49333619
78B:B:G144 2.176518
79B:B:Y145 4.4891018
80B:B:F151 3.72571719
81B:B:T159 4.4525419
82B:B:S161 5.99519
83B:B:G162 3.74419
84B:B:D163 7.38519
85B:B:L168 3.1175416
86B:B:W169 10.466518
87B:B:I171 3.775416
88B:B:F180 7.4617
89B:B:H183 7.41857719
90B:B:G185 2.69415
91B:B:D186 5.0375419
92B:B:L190 3.694185
93B:B:F199 6.495419
94B:B:V200 8.825416
95B:B:S201 4.2575419
96B:B:C204 4.775617
97B:B:D205 6.656519
98B:B:K209 11.055416
99B:B:L210 5.194515
100B:B:W211 8.14333618
101B:B:Q220 7.758517
102B:B:F222 5.446518
103B:B:H225 8.06719
104B:B:D228 7.204519
105B:B:I232 4.7075418
106B:B:F234 6.45415
107B:B:F235 5.525717146
108B:B:P236 7.7854147
109B:B:F241 6.24875816
110B:B:T243 3.912518
111B:B:S245 5.5025419
112B:B:D246 5.4575419
113B:B:D247 7.4975419
114B:B:T249 5.848516
115B:B:R251 13.812518
116B:B:F253 6.068516
117B:B:R256 7.525409
118B:B:D258 5.966517
119B:B:L261 4.51405
120B:B:Y264 4.882505
121B:B:I273 6.355496
122B:B:F278 3.923336147
123B:B:R283 6.7985139
124B:B:Y289 7.31597
125B:B:D290 7.9775416
126B:B:W297 8.294598
127B:B:D298 7.114139
128B:B:K301 4.7456135
129B:B:H311 8.684109
130B:B:R314 10.3175418
131B:B:T321 5.092537
132B:B:S331 5.88254109
133B:B:W332 13.172519
134B:B:L336 4.0775437
135B:B:K337 4.80754106
136B:B:W339 8.818336109
137G:G:I9 2.8402
138G:G:L19 3.3765169
139G:G:R27 5.866518
140G:G:D48 6.5825209
141G:G:L51 3.125406
142G:G:N59 2.582509
143G:G:F61 4.29833638
144R:R:H21 5.6025407
145R:R:Y22 6.284529
146R:R:V25 4.3025406
147R:R:L28 3.0725423
148R:R:F46 4.775427
149R:R:I53 2.295407
150R:R:M74 5.208558
151R:R:F76 5.595404
152R:R:F77 6.46508
153R:R:N80 5.1165119
154R:R:L81 5.26559
155R:R:D85 6.7559
156R:R:Y92 3.78667626
157R:R:N95 8526
158R:R:S99 7.9525425
159R:R:T103 6.05425
160R:R:F104 7.31833627
161R:R:W111 10.1375429
162R:R:F112 5.22167626
163R:R:R114 5.838526
164R:R:E115 6.058525
165R:R:F119 4.59525
166R:R:L129 6.1075459
167R:R:I132 4.2375459
168R:R:E135 6.246559
169R:R:R136 3.06833659
170R:R:P145 4.4025405
171R:R:Y146 4.105407
172R:R:R153 5.736555
173R:R:W162 3.337147119
174R:R:L182 7.71254223
175R:R:T187 4.145425
176R:R:I188 3.972524
177R:R:Y192 6.7523
178R:R:Y196 7.64667626
179R:R:I207 3.6575407
180R:R:Y215 3.28167659
181R:R:Y219 6.31576
182R:R:N234 9.348574
183R:R:R237 5.61674
184R:R:L241 3.485478
185R:R:V249 2.1975408
186R:R:F252 3.7075409
187R:R:W256 5.80375828
188R:R:F260 11.406526
189R:R:L262 3.59425
190R:R:F263 3.12833626
191R:R:D266 7.6825424
192R:R:C274 3.156522
193R:R:L277 5.652522
194R:R:W282 3.105424
195R:R:N294 5.4625459
196R:R:Y298 4.37429759
197R:R:M305 3.70333658
198L:L:?1 7.044671520
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L69 B:B:R68 15.39562.43NoYes355
2B:B:I81 B:B:L69 15.7512.85YesNo075
3B:B:I81 B:B:L126 17.20944.28YesNo075
4B:B:L126 B:B:V112 25.5934.47NoNo058
5B:B:V112 B:B:Y105 25.76652.52NoYes086
6B:B:G109 B:B:Y105 26.63645.79NoYes056
7B:B:G109 B:B:S108 26.81081.86NoNo056
8B:B:N110 B:B:S108 26.98675.96NoNo046
9B:B:N110 B:B:Y111 27.34063.49NoYes044
10B:B:F151 B:B:Y111 28.7122.06YesYes194
11B:B:F151 B:B:I157 29.76822.51YesNo197
12B:B:I157 B:B:T159 30.68573.04NoYes179
13B:B:H142 B:B:T159 31.18754.11YesYes199
14B:B:H142 B:B:S161 26.436212.55YesYes199
15A:A:S206 B:B:G144 15.12661.86YesYes188
16A:A:S206 A:A:W211 14.97362.47YesYes189
17A:A:F215 A:A:W211 46.21782YesYes199
18A:A:F199 A:A:F215 52.65216.43YesYes159
19A:A:F199 A:A:K35 99.82094.96YesNo159
20A:A:K35 R:R:Y146 1007.17NoYes097
21B:B:G162 B:B:S161 19.91353.71YesYes199
22B:B:G162 B:B:Y145 18.08075.79YesYes198
23A:A:W211 B:B:Y145 35.11081.93YesYes198
24B:B:L117 B:B:Y145 28.79893.52YesYes198
25B:B:L117 B:B:W99 28.82924.56YesYes199
26A:A:F199 B:B:W99 47.862613.03YesYes159
27A:A:T219 R:R:Y146 93.53363.75NoYes077
28A:A:R208 A:A:W211 13.22858YesYes099
29A:A:I253 A:A:R208 10.28235.01YesYes089
30A:A:K210 B:B:Y145 46.48763.58YesYes198
31A:A:K210 B:B:D228 22.785612.44YesYes199
32A:A:K210 B:B:D246 22.78772.77YesYes199
33A:A:C214 B:B:W99 13.10932.61YesYes179
34B:B:W332 B:B:Y59 13.13379.65YesYes198
35A:A:T219 A:A:V342 88.82233.17NoNo077
36A:A:F223 A:A:I253 10.91782.51NoYes098
37A:A:W258 B:B:R314 17.54312YesYes158
38A:A:S263 A:A:V342 88.69946.46NoNo077
39A:A:K345 A:A:S263 88.63913.06NoNo057
40A:A:K345 R:R:R237 87.94978.66NoYes054
41R:R:R237 R:R:S226 89.26062.64YesNo745
42R:R:S226 R:R:V222 95.80571.62NoNo758
43R:R:L241 R:R:V222 95.33614.47YesNo788
44A:A:L353 R:R:R136 94.77642.43NoYes079
45A:A:L353 R:R:L241 94.86384.15NoYes078
46B:B:D228 B:B:S227 24.66922.94YesNo196
47B:B:S227 B:B:S245 47.21693.26NoYes169
48B:B:H225 B:B:S245 27.13529.76YesYes199
49B:B:H225 B:B:T243 18.86295.48YesYes198
50B:B:F241 B:B:T243 21.15022.59YesYes168
51B:B:F222 B:B:F241 13.40429.65YesYes186
52B:B:D258 B:B:F222 29.97555.97YesYes178
53B:B:D258 B:B:R22 22.98165.96YesNo176
54B:B:I18 B:B:R22 22.10366.26NoNo076
55B:B:I18 G:G:L19 20.33671.43NoYes079
56B:B:L14 G:G:L19 15.91839.69YesYes089
57B:B:D246 B:B:S227 22.71722.94YesNo196
58B:B:I229 B:B:S245 19.02413.1NoYes179
59B:B:I229 B:B:T243 18.84993.04NoYes178
60B:B:F253 B:B:T243 13.74313.89YesYes168
61B:B:F222 B:B:F253 20.09792.14YesYes186
62B:B:R283 G:G:L51 10.9962.43YesYes096
63B:B:L300 B:B:R283 17.47199.72NoYes069
64B:B:L300 G:G:C41 18.45436.35NoNo067
65B:B:F235 G:G:C41 18.75872.79YesNo1467
66B:B:F235 B:B:F278 20.67745.36YesYes1467
67B:B:F278 B:B:L252 11.38592.44YesNo077
68B:B:L252 B:B:Y264 13.63097.03NoYes075
69B:B:F278 B:B:L285 11.28637.31YesNo076
70B:B:L285 B:B:Y264 11.44674.69NoYes065
71B:B:C250 B:B:Y264 26.16044.03NoYes085
72B:B:C250 B:B:I273 26.2666.55NoYes986
73B:B:I273 B:B:Y289 27.044912.09YesYes967
74B:B:D291 B:B:Y289 28.44024.6NoYes087
75B:B:C271 B:B:D291 29.06666.22NoNo058
76B:B:D290 B:B:R314 29.867517.87YesYes168
77B:B:C271 B:B:D290 29.21264.67NoYes156
78R:R:R136 R:R:Y215 43.50272.06YesYes599
79R:R:I211 R:R:Y215 42.68963.63NoYes089
80R:R:F252 R:R:I211 41.89112.51YesNo098
81R:R:F252 R:R:W256 83.97515.01YesYes098
82R:R:L122 R:R:W256 34.16325.69NoYes068
83L:L:?1 R:R:L122 33.96498.36YesNo006
84L:L:?1 R:R:R114 10.67646.29YesYes206
85R:R:R114 R:R:W111 10.29528YesYes269
86R:R:F112 R:R:W111 12.351210.02YesYes269
87R:R:R136 R:R:Y298 45.514.12YesYes599
88R:R:L129 R:R:Y298 42.61068.21YesYes599
89R:R:F252 R:R:L129 42.43282.44YesYes099
90R:R:F260 R:R:W256 41.93676.01YesYes268
91L:L:?1 R:R:F260 33.9734.2YesYes206
92L:L:?1 R:R:E115 11.50466.86YesYes205
93R:R:E115 R:R:W111 10.27685.45YesYes259
94R:R:F263 R:R:I188 13.61082.51YesYes264
95L:L:?1 R:R:N95 14.402918.96YesYes206
96R:R:N95 R:R:Y92 14.02464.65YesYes266
97L:L:?1 R:R:M118 14.40469.76YesNo206
98R:R:M118 R:R:Y92 13.99248.38NoYes266
99B:B:R314 B:B:W332 12.589818.99YesYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L28 R:R:Y22 2.34 2 Yes Yes 3 9 2 1
R:R:T103 R:R:Y22 8.74 2 Yes Yes 5 9 1 1
R:R:F104 R:R:Y22 5.16 2 Yes Yes 7 9 2 1
R:R:P190 R:R:Y22 11.13 0 No Yes 4 9 2 1
L:L:?1 R:R:Y22 4.05 2 Yes Yes 0 9 0 1
R:R:F104 R:R:L28 3.65 2 Yes Yes 7 3 2 2
R:R:R31 R:R:T103 2.59 2 No Yes 4 5 1 1
R:R:F104 R:R:R31 3.21 2 Yes No 7 4 2 1
L:L:?1 R:R:R31 10.48 2 Yes No 0 4 0 1
R:R:N95 R:R:Y92 4.65 2 Yes Yes 6 6 1 2
R:R:M118 R:R:Y92 8.38 2 No Yes 6 6 1 2
R:R:N95 R:R:S99 5.96 2 Yes Yes 6 5 1 1
R:R:N95 R:R:R114 4.82 2 Yes Yes 6 6 1 1
R:R:M118 R:R:N95 5.61 2 No Yes 6 6 1 1
L:L:?1 R:R:N95 18.96 2 Yes Yes 0 6 0 1
R:R:G100 R:R:S99 3.71 0 No Yes 6 5 2 1
R:R:R114 R:R:S99 6.59 2 Yes Yes 6 5 1 1
L:L:?1 R:R:S99 15.55 2 Yes Yes 0 5 0 1
R:R:F104 R:R:T103 7.78 2 Yes Yes 7 5 2 1
L:L:?1 R:R:T103 5.09 2 Yes Yes 0 5 0 1
R:R:R114 R:R:W111 8 2 Yes Yes 6 9 1 2
R:R:E115 R:R:W111 5.45 2 Yes Yes 5 9 1 2
R:R:E115 R:R:R114 3.49 2 Yes Yes 5 6 1 1
L:L:?1 R:R:R114 6.29 2 Yes Yes 0 6 0 1
R:R:E115 R:R:L189 6.63 2 Yes No 5 5 1 1
R:R:E115 R:R:Y192 7.86 2 Yes Yes 5 3 1 2
L:L:?1 R:R:E115 6.86 2 Yes Yes 0 5 0 1
L:L:?1 R:R:M118 9.76 2 Yes No 0 6 0 1
R:R:F119 R:R:Y192 4.13 2 Yes Yes 5 3 1 2
R:R:F119 R:R:Y196 10.32 2 Yes Yes 5 6 1 2
R:R:C200 R:R:F119 2.79 2 No Yes 6 5 2 1
L:L:?1 R:R:F119 4.2 2 Yes Yes 0 5 0 1
R:R:L122 R:R:W256 5.69 0 No Yes 6 8 1 2
L:L:?1 R:R:L122 8.36 2 Yes No 0 6 0 1
R:R:A165 R:R:G123 1.95 0 No No 8 5 2 1
R:R:F263 R:R:I188 2.51 2 Yes Yes 6 4 1 2
R:R:L189 R:R:Y192 8.21 2 No Yes 5 3 1 2
L:L:?1 R:R:L189 4.78 2 Yes No 0 5 0 1
R:R:Y192 R:R:Y196 4.96 2 Yes Yes 3 6 2 2
R:R:C200 R:R:Y196 2.69 2 No Yes 6 6 2 2
R:R:F263 R:R:I197 2.51 2 Yes No 6 6 1 2
R:R:F260 R:R:I201 5.02 2 Yes No 6 4 1 2
R:R:F263 R:R:I201 2.51 2 Yes No 6 4 1 2
R:R:F204 R:R:W256 4.01 2 No Yes 7 8 2 2
R:R:F204 R:R:F260 38.58 2 No Yes 7 6 2 1
R:R:L259 R:R:W256 2.28 0 No Yes 6 8 2 2
R:R:F260 R:R:W256 6.01 2 Yes Yes 6 8 1 2
R:R:F263 R:R:L259 4.87 2 Yes No 6 6 1 2
R:R:F260 R:R:F263 3.22 2 Yes Yes 6 6 1 1
L:L:?1 R:R:F260 4.2 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F263 3.15 2 Yes Yes 0 6 0 1
L:L:?1 R:R:I284 2.46 2 Yes No 0 5 0 1
R:R:F119 R:R:G169 1.51 2 Yes No 5 7 1 2
L:L:?1 R:R:G123 1.48 2 Yes No 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
85.71Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
80.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
73.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
70.59Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
68.75Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
64.29Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
63.16Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
62.50Single7C4SS1P7C4S-S1P3-S1P
62.50Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
60.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
60.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
60.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
60.00Consensuss1p_offOrthosteric Ligands1p1_off
57.89Consensuslpl_onOrthosteric Ligands1p_on lpa_on
56.25Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
56.25Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
56.25Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
55.56Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
53.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
52.94Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
52.63Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
52.63Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
50.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
50.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
50.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
50.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
50.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
50.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
50.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
50.00Single8E0GBU728E0G-μ-BU72
50.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
50.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
47.62Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
47.37Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
47.37Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
47.37Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
47.37Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
47.37Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
47.06Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
47.06Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
47.06Single6DRXLisuride6DRX-5-HT2B-Lisuride
47.06Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
47.06Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
47.06Consensusgi_hcarOrthosteric Ligandgi_hca
47.06Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
46.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
45.45Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
45.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
45.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
45.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
45.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
45.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
45.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
44.44Single5C1MBU725C1M-μ-BU72
44.44Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
44.44Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
44.44Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
44.44Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
44.44Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
44.44Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
44.44Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
44.44Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
44.44Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
44.44Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
43.75Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
43.75Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
43.48Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
43.48Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
42.86Single5ZTYAM102575ZTY-CB2-AM10257
42.86Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
42.86Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
42.86Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
42.86Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
42.86Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
42.11Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
42.11Single4DJHJDTic4DJH-κ-JDTic
42.11Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
42.11Single6H7JIsoprenaline6H7J-β1-Isoprenaline
42.11Single6TQ7SB-3348676TQ7-OX1-SB-334867
42.11Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
42.11Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
42.11Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
42.11Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
42.11Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
42.11Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
42.11Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
42.11Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
42.11Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
42.11Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
42.11Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
42.11Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
42.11Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
42.11Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
42.11Consensuslpa_onOrthosteric Ligandlpa1_on
42.11Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
42.11Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
41.67Single7C61Ergotamine7C61-5-HT1B-Ergotamine
41.67Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
41.18Single6IQLL7458706IQL-D4-L745870
41.18Single6TPGEMPA6TPG-OX2-EMPA
41.18Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
41.18Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
41.18Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
41.18Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
41.18Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
41.18Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
41.18Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
41.18Single8K5CAcipimox8K5C-HCA2-Acipimox
41.18Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
41.18Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
40.91Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
40.91Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
40.00Single4LDEBI1671074LDE-β2-BI167107
40.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
40.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
40.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
40.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
40.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
40.00Single7YITNalfurafine7YIT-κ-Nalfurafine
40.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
40.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
40.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
40.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
40.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
40.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
40.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
40.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
40.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
39.29Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
39.29Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
39.13Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
39.13Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
39.13Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
39.13Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
39.13Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
38.89Single2Y04Salbutamol2Y04-β1-Salbutamol
38.89Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
38.89Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
38.89Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
38.89Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
38.89Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
38.89Single7UL4Alvimopan7UL4-μ-Alvimopan
38.89Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
38.89Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
38.89Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
38.89Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
38.89Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
38.89Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
38.89Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
38.89Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
38.89Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
38.46Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
38.10Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
38.10Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
38.10Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
38.10Single7UM4AS26747237UM4-5-HT5A-AS2674723
38.10Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
38.10Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
38.10Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
38.10Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
38.10Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
38.10Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
38.10Consensusendothelin_offOrthosteric Ligandetb_off
38.10Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
38.10Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
38.10Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.10Consensusorexin_onOrthosteric Ligandox2_on
37.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
37.50Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
37.50Single7SRQLSD7SRQ-5-HT2B-LSD
37.50Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
37.50Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
37.50Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
37.50Single8K5BNiacin8K5B-HCA2-Niacin
36.84Single2Y03Isoprenaline2Y03-β1-Isoprenaline
36.84Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
36.84Single5TVNLSD5TVN-5-HT2B-LSD
36.84Single5WQCEMPA5WQC-OX2-EMPA
36.84Single6E67BI1671076E67-β2-BI167107-Gs (fused)
36.84Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
36.84Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
36.84Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
36.84Single6TP6Filorexant6TP6-OX1-Filorexant
36.84Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
36.84Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
36.84Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
36.84Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
36.84Single7WC6LSD7WC6-5-HT2A-LSD
36.84Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.84Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.84Single7YXAONO-54306087YXA-S1P5-ONO-5430608
36.84Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
36.84Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
36.84Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
36.84Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
36.84Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
36.84Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
36.84Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
36.84Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
36.84Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
36.84Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
36.36Single4UG2CGS216804UG2-A2A-CGS21680
36.36Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
36.36Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
36.36Single7SK9CCX6627SK9-ACKR3-CCX662
36.36Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
36.36Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single8X5YAstemizole8X5Y-H1-Astemizole
36.36Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
36.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
36.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
35.71Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
35.71Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
35.71Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
35.29Single5DHHSB-6121115DHH-NOP-SB-612111
35.29Single6AKXA4R6AKX-CCR5-A4R
35.29Single6B73PubChem 1319551386B73-κ-PubChem 131955138
35.29Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
35.29Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
35.29Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.29Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.29Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
35.29Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
35.29Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.29Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
35.29Single8IHKAcifran8IHK-HCA3-Acifran
35.29Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
35.29Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.29Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
35.29Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
35.29Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.29Consensusorexin_offOrthosteric Ligandox2_off ox1_off
35.00Single2YDVNECA2YDV-A2A-NECA
35.00Single3P0GBI1671073P0G-β2-BI167107
35.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
35.00Single4UHRCGS216804UHR-A2A-CGS21680
35.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
35.00Single5G53NECA5G53-A2A-NECA-Gs
35.00Single5X93K-87945X93-ETB-K-8794
35.00Single5XR8AM8415XR8-CB1-AM841
35.00Single5XRAAM115425XRA-CB1-AM11542
35.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
35.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
35.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
35.00Single6WGTLSD6WGT-5-HT2A-LSD
35.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
35.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
35.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
35.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
35.00Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
35.00Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
35.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
35.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
35.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
35.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
35.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
35.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
35.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
35.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
35.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
35.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
35.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
35.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
35.00Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
35.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
35.00Consensuslpa_offOrthosteric Ligandlpa1_off
34.78Single4XT1Fractalkine4XT1-US28-Fractalkine
34.78Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
34.78Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
34.78Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
34.78Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
34.78Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
34.78Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.78Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
34.78Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
34.78Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
34.62Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
34.62Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
34.48Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
33.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
33.33Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
33.33Single3RZECidoxepin3RZE-H1-Cidoxepin
33.33Single4AMIBucindolol4AMI-β1-Bucindolol
33.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
33.33Single4MBSMaraviroc4MBS-CCR5-Maraviroc
33.33Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
33.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
33.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
33.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
33.33Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
33.33Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
33.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
33.33Single6PS4ICI 118-5516PS4-β2-ICI 118-551
33.33Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
33.33Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
33.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
33.33Single6TP3Nemorexant6TP3-OX1-Nemorexant
33.33Single6TPNHTL66416TPN-OX2-HTL6641
33.33Single6V9SGTPL114036V9S-OX1-GTPL11403
33.33Single6VI4JDTic6VI4-κ-JDTic
33.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
33.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
33.33Single6ZG9GSK10347026ZG9-M1-GSK1034702
33.33Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
33.33Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
33.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Single7DFPSpiperone7DFP-D2-Spiperone
33.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
33.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
33.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
33.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
33.33Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
33.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
33.33Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GGKEpinephrine8GGK-β2-Epinephrine
33.33Single8GGMEpinephrine8GGM-β2-Epinephrine
33.33Single8GGPEpinephrine8GGP-β2-Epinephrine
33.33Single8GGQEpinephrine8GGQ-β2-Epinephrine
33.33Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
33.33Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
33.33Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
33.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
33.33Single8JJ8Formoterol8JJ8-β2-Formoterol
33.33Single8JJLOlodaterol8JJL-β2-Olodaterol
33.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
33.33Single8JWZAB9288JWZ-A2A-AB928-Na
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8WU1KCA8WU1-CB1-KCA-Arrestin1
33.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
33.33Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
33.33Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
33.33Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
33.33Consensuschemokine_offOrthosteric Ligandcxcr_off
33.33Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
33.33Consensuscxcr_offOrthosteric Ligandcxcr4_off
33.33Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
33.33Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
33.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
33.33Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
33.33Consensushca_onOrthosteric Ligandhca2_on hca3_on
33.33Consensushcar_onOrthosteric Ligandhca_on
33.33Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
33.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
33.33Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
33.33Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
33.33Consensussensory_offOrthosteric Ligandopsin_off
32.14Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
32.14Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
32.14Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
32.00Single5WF5UK-4320975WF5-A2A-UK-432097
32.00Single6PT2KGCHM076PT2-δ-KGCHM07
32.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
32.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
32.00Consensusangiotensin_onOrthosteric Ligandat1_on
32.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
32.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
31.82Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
31.82Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
31.82Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
31.82Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
31.82Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
31.82Single6H7LDobutamine6H7L-β1-Dobutamine
31.82Single6IBLArformoterol6IBL-β1-Arformoterol
31.82Single6K1QIRL25006K1Q-ETB-IRL2500
31.82Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
31.82Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
31.82Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
31.82Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
31.82Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
31.82Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
31.82Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
31.82Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
31.58Single2Y02Carmoterol2Y02-β1-Carmoterol
31.58Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
31.58Single3NY8ICI 118-5513NY8-β2-ICI 118-551
31.58Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
31.58Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
31.58Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
31.58Single4MQSIperoxo4MQS-M2-Iperoxo
31.58Single4U14Tiotropium4U14-M3-Tiotropium
31.58Single4YAYZD-71554YAY-AT1-ZD-7155
31.58Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
31.58Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
31.58Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
31.58Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
31.58Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
31.58Single6H7MSalbutamol6H7M-β1-Salbutamol
31.58Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
31.58Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
31.58Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
31.58Single6PS1Timolol6PS1-β2-Timolol
31.58Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
31.58Single6TOTLemborexant6TOT-OX1-Lemborexant
31.58Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
31.58Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
31.58Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
31.58Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
31.58Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
31.58Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
31.58Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
31.58Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
31.58Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
31.58Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
31.58Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
31.58Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.58Single7WC7Lisuride7WC7-5-HT2A-Lisuride
31.58Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
31.58Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
31.58Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
31.58Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
31.58Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
31.58Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
31.58Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GGJEpinephrine8GGJ-β2-Epinephrine
31.58Single8GGNEpinephrine8GGN-β2-Epinephrine
31.58Single8GGOEpinephrine8GGO-β2-Epinephrine
31.58Single8GGUEpinephrine8GGU-β2-Epinephrine
31.58Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.58Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
31.58Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
31.58Single8JJOAlprenolol8JJO-β2-Alprenolol
31.58Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
31.58Single8K5DGSK2560738K5D-HCA2-GSK256073
31.58Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
31.58Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
31.58Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
31.58Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single8X63Mepyramine8X63-H1-Mepyramine
31.58Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
31.58Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
31.58Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
31.58Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
31.58Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
31.58Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.58Consensusblt_onOrthosteric Ligandblt1_on
31.58Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
31.58Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
31.58Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.58Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
31.58Consensushcar_offOrthosteric Ligandsuccinate_off
31.58Consensusleuko_onOrthosteric Ligandblt_on
31.58Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
31.58Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
31.58Consensustar_onOrthosteric Ligandta1_on
31.25Single3OE6IT1t3OE6-CXCR4-IT1t
31.25Single3OE8IT1t3OE8-CXCR4-IT1t
31.25Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
31.25Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
31.25Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
30.77Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.77Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
30.77Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
30.77Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
30.77Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
30.77Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.43Single3NY9PubChem 9131033NY9-β2-PubChem 913103
30.43Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
30.43Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
30.43Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
30.43Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.43Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
30.43Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
30.43Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
30.43Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
30.43Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.43Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
30.43Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
30.43Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
30.43Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
30.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
30.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
30.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
30.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
30.00Single5WIUNemonapride5WIU-D4-Nemonapride
30.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
30.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
30.00Single5XPRBosentan5XPR-ETB-Bosentan
30.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
30.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
30.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
30.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
30.00Single6PS6Timolol6PS6-β2-Timolol
30.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
30.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
30.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
30.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
30.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
30.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
30.00Single7XKAEpinephrine7XKA-β2-Epinephrine
30.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
30.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
30.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
30.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
30.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
30.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
30.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
30.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
30.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
30.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
30.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
30.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
29.63Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
29.63Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
29.63Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
29.63Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
29.41Single3OE9IT1t3OE9-CXCR4-IT1t
29.41Single6TP4ACT-4622066TP4-OX1-ACT-462206
29.41Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
29.41Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
29.41Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
29.41Single8GGSEpinephrine8GGS-β2-Epinephrine
29.41Single8GH1Epinephrine8GH1-β2-Epinephrine
29.41Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
29.41Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
29.41Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
29.41Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
29.41Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
29.41Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
29.41Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
29.17Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
29.17Single4IARErgotamine4IAR-5-HT1B-Ergotamine
29.17Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
29.17Single7F8XNN90567F8X-CCKA-NN9056
29.17Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
29.17Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
29.17Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
29.17Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
29.17Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
29.17Consensussst_onOrthosteric Ligandsst2_on sst4_on
29.17Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
29.03Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
29.03Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
28.57Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
28.57Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
28.57Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
28.57Single4U15Tiotropium4U15-M3-Tiotropium
28.57Single4XT3Fractalkine4XT3-US28-Fractalkine
28.57Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
28.57Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
28.57Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
28.57Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
28.57Single6E59L-7607356E59-NK1-L-760735
28.57Single6J20Aprepitant6J20-NK1-Aprepitant
28.57Single6J21Aprepitant6J21-NK1-Aprepitant
28.57Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
28.57Single6OL9Tiotropium6OL9-M5-Tiotropium
28.57Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
28.57Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
28.57Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
28.57Single7TUYGSK682753A7TUY-GPR183-GSK682753A
28.57Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
28.57Single7W41PD1762527W41-BB2-PD176252
28.57Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
28.57Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
28.57Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
28.57Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
28.57Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
28.57Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
28.57Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
28.57Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
28.57Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
28.57Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
28.57Consensusa2_onOrthosteric Liganda2a_on a2b_on
28.57Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
28.57Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
28.57Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
28.57Consensusbombesin_offOrthosteric Ligandbb2_off
28.57Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
28.57Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
28.57Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
28.57Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
28.57Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
28.57Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
28.57Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
28.57Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
28.57Consensushistamine_offOrthosteric Ligandh1_off
28.57Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
28.57Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
28.57Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
28.57Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
28.57Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
28.12Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.00Single3QAKUK-4320973QAK-A2A-UK-432097
28.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
28.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
28.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
28.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
28.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
27.78Single3ODUIT1t3ODU-CXCR4-IT1t
27.78Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
27.78Single4S0VSuvorexant4S0V-OX2-Suvorexant
27.78Single5WS3EMPA5WS3-OX2-EMPA
27.78Single5ZKQABT-4915ZKQ-PAF-ABT-491
27.78Single6AKYMaraviroc6AKY-CCR5-Maraviroc
27.78Single6KUXRS-799486KUX-α2a-RS-79948
27.78Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
27.78Single6TODEMPA6TOD-OX1-EMPA-Na
27.78Single6TPJSuvorexant6TPJ-OX2-Suvorexant
27.78Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
27.78Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
27.78Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
27.78Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
27.78Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
27.78Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
27.78Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
27.78Single7XRRLemborexant7XRR-OX2-Lemborexant
27.78Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGVEpinephrine8GGV-β2-Epinephrine
27.78Single8GGXEpinephrine8GGX-β2-Epinephrine
27.78Single8GH0Epinephrine8GH0-β2-Epinephrine
27.78Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
27.78Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
27.78Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
27.78Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.78Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
27.78Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
27.78Consensusalpha1_onOrthosteric Ligandalpha1a_on
27.78Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
27.78Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusmglu_onOther Ligandmglu2_on mglu4_on
27.78Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
27.59Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
27.59Consensusendothelin_onOrthosteric Ligandetb_on eta_on
27.27Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.27Single5CXVTiotropium5CXV-M1-Tiotropium
27.27Single6A93Risperidone6A93-5-HT2A-Risperidone
27.27Single6CM4Risperidone6CM4-D2-Risperidone
27.27Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
27.27Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
27.27Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
27.27Single6MXTSalmeterol6MXT-β2-Salmeterol
27.27Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.27Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
27.27Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
27.27Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
27.27Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
27.27Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
27.27Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
27.27Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
27.27Consensusdp_offOrthosteric Liganddp2_off
27.27Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
27.27Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
27.27Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
27.27Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.92Single6W25SHU91196W25-MC4-SHU9119-Ca
26.92Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
26.92Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
26.92Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
26.92Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.92Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
26.92Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
26.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
26.67Single6IGLIRL16206IGL-ETB-IRL1620
26.67Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
26.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
26.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
26.67Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.67Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
26.67Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single2YDOAdenosine2YDO-A2A-Adenosine
26.32Single6DS0Ly2660976DS0-5-HT2B-Ly266097
26.32Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
26.32Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
26.32Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
26.32Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
26.32Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
26.32Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
26.32Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.32Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
26.32Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
26.32Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GGIEpinephrine8GGI-β2-Epinephrine
26.32Single8GGLEpinephrine8GGL-β2-Epinephrine
26.32Single8GGTEpinephrine8GGT-β2-Epinephrine
26.32Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
26.32Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
26.32Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
26.32Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
26.32Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
26.32Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
26.32Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
26.32Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.32Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
26.09Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
26.09Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
26.09Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
26.09Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
26.09Single7EZCUKA7EZC-A2A-UKA
26.09Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
26.09Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
26.09Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
26.09Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
26.09Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
26.09Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.09Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
26.09Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
26.09Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
26.09Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
25.93Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.93Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
25.93Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
25.93Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.93Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
25.93Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.81Single6IGKEndothelin-36IGK-ETB-Endothelin-3
25.81Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
25.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
25.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
25.00Single2Y01Dobutamine2Y01-β1-Dobutamine
25.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
25.00Single4DAJTiotropium4DAJ-M3-Tiotropium
25.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
25.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
25.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
25.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
25.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
25.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
25.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
25.00Single6GPSMK08126GPS-CCR2-MK0812
25.00Single6IIVDaltroban6IIV-TP-Daltroban
25.00Single6PT3DPI-2876PT3-δ-DPI-287
25.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
25.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
25.00Single7BU7BI1671077BU7-β1-BI167107
25.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
25.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
25.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
25.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
25.00Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
25.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
25.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
25.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
25.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
25.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
25.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
25.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
25.00Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
25.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
25.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
25.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
25.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
25.00Single8X64Desloratadine8X64-H1-Desloratadine
25.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
25.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
25.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
25.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
25.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
25.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
25.00Consensuscck_offOrthosteric Ligandccka_off
25.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
25.00Consensusclass-d_offOrthosteric Ligandste2_off
25.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
25.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.00Consensusglp_onOrthosteric Ligandglp1_on glp2_on
25.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
25.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
25.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
25.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
25.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
25.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
25.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
25.00Consensustachykinin_offOrthosteric Ligandnk1_off
25.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
24.24Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
24.14Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
24.14Single6FJ3PTH6FJ3-PTH1-PTH
24.14Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
24.14Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
24.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
24.14Single7SK3CXCL127SK3-ACKR3-CXCL12
24.14Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
24.14Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
24.14Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
24.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
24.14Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
24.14Consensusclass-d_onOrthosteric Ligandste2_on
24.14Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
24.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
24.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
24.00Single7QA8Peptide7QA8-STE2-Peptide
24.00Single7QA8Peptide7QA8-STE2-Peptide
24.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
24.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
24.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
24.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
24.00Consensusclass-d_offOrthosteric Ligandste2_off
24.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
23.81Single2Y00Dobutamine2Y00-β1-Dobutamine
23.81Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
23.81Single5NM2ZM2413855NM2-A2A-ZM241385-Na
23.81Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
23.81Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
23.81Single6D26Fevipiprant6D26-DP2-Fevipiprant
23.81Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
23.81Single6GPXMK08126GPX-CCR2-MK0812
23.81Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
23.81Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
23.81Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
23.81Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
23.81Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
23.81Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
23.81Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
23.81Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
23.81Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single8EA0Iperoxo8EA0-M3-Iperoxo
23.81Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
23.81Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
23.81Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
23.81Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
23.81Single8QOTNanobody E8QOT-μ-Nanobody E
23.81Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
23.81Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
23.81Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
23.81Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
23.81Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
23.81Consensusep_offOrthosteric Ligandep4_off
23.81Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
23.81Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
23.81Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
23.53Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
23.53Single6LI0GTPL98046LI0-GPR52-GTPL9804
23.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.53Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
23.53Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
23.53Single8GGREpinephrine8GGR-β2-Epinephrine
23.53Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
23.53Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
23.53Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
23.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
23.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
23.33Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
23.33Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
23.33Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
23.33Consensusgi_class-dOrthosteric Ligandgi_ste
23.33Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.33Consensusgo_class-b1Orthosteric Ligandgo_crf
23.33Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
23.33Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.08Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
23.08Single6HLOAprepitant6HLO-NK1-Aprepitant
23.08Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
23.08Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
23.08Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
23.08Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
23.08Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
23.08Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
22.86Consensuspth_onOrthosteric Ligandpth1_on pth2_on
22.73Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
22.73Single4BV0Neurotensin4BV0-NTS1-Neurotensin
22.73Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
22.73Single5V54Methiothepin5V54-5-HT1B-Methiothepin
22.73Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
22.73Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.73Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
22.73Single7EPENAM5637EPE-mGlu-NAM563
22.73Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
22.73Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
22.73Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
22.73Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
22.73Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
22.73Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
22.73Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
22.73Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
22.73Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
22.73Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.73Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
22.73Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.73Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
22.73Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
22.73Consensus5ht1_offOrthosteric Ligand5ht1b_off
22.73Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
22.73Consensusadenosine_offOrthosteric Liganda1_off a2_off
22.73Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.73Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
22.73Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.73Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
22.73Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
22.73Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
22.58Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
22.58Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
22.58Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single8IY6Endothelin-18IY6-ETB-Endothelin-1
22.58Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
22.58Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
22.58Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.58Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
22.22Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
22.22Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
22.22Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
22.22Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
22.22Single3OE0CVX153OE0-CXCR4-CVX15
22.22Single3PBLEticlopride3PBL-D3-Eticlopride
22.22Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
22.22Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
22.22Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
22.22Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
22.22Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
22.22Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
22.22Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
22.22Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
22.22Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
22.22Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGYEpinephrine8GGY-β2-Epinephrine
22.22Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
22.22Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
22.22Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
22.22Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
22.22Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
22.22Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
21.88Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
21.88Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.88Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
21.74Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
21.74Single4XEENeurotensin4XEE-NTS1-Neurotensin
21.74Single4XESNeurotensin4XES-NTS1-Neurotensin
21.74Single5X33BIIL2605X33-BLT1-BIIL260
21.74Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
21.74Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
21.74Single6HLPNetupitant6HLP-NK1-Netupitant
21.74Single6IIURamatroban6IIU-TP-Ramatroban
21.74Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
21.74Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
21.74Single7K15MKD0467K15-BLT1-MKD046-Na
21.74Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.74Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
21.74Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
21.74Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.74Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
21.74Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
21.74Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
21.74Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
21.74Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
21.74Consensusblt_offOrthosteric Ligandblt1_off
21.74Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
21.74Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.74Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
21.74Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.74Consensusgs_steroidOrthosteric Ligandgs_bileacid
21.74Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
21.74Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.62Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
21.43Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
21.43Single6JODAngiotensin II6JOD-AT2-Angiotensin II
21.43Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
21.43Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
21.43Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
21.43Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
21.43Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.21Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
21.21Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
21.21Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
21.05Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
21.05Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
21.05Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
21.05Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
21.05Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
21.05Single3PWHZM2413853PWH-A2A-ZM241385
21.05Single5K2DZM2413855K2D-A2A-ZM241385
21.05Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
21.05Single5U09Taranabant5U09-CB1-Taranabant
21.05Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
21.05Single6JZHZM2413856JZH-A2A-ZM241385-Na
21.05Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
21.05Single6ME2Ramelteon6ME2-MT1-Ramelteon
21.05Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.05Single6PS7ZM2413856PS7-A2A-ZM241385-Na
21.05Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.05Single7BR3Elagolix7BR3-GnRH1-Elagolix
21.05Single7F8ULintitript7F8U-CCKA-Lintitript
21.05Single7F8YDevazepide7F8Y-CCKA-Devazepide
21.05Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
21.05Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
21.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
21.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
21.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
21.05Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
21.05Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
21.05Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
21.05Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
21.05Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GGWEpinephrine8GGW-β2-Epinephrine
21.05Single8GNGIstradefylline8GNG-A2A-Istradefylline
21.05Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
21.05Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
21.05Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8IWESpermidine8IWE-TAAR9-Spermidine
21.05Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
21.05Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
21.05Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
21.05Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
21.05Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
21.05Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
21.05Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
21.05Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
21.05Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.05Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
21.05Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
20.83Single4BUONeurotensin4BUO-NTS1-Neurotensin
20.83Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.83Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
20.83Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.83Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
20.83Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
20.83Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.83Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
20.83Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
20.83Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensussteroid_onOrthosteric Ligandbileacid_on
20.69Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.69Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
20.69Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.69Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
20.69Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
20.69Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.69Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.59Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.59Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
20.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
20.00Single3REYPubChem 56973REY-A2A-PubChem 5697
20.00Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
20.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
20.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
20.00Single5EE7MK08935EE7-Glucagon-MK0893
20.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
20.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5JTBZM2413855JTB-A2A-ZM241385
20.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
20.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
20.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
20.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
20.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
20.00Single5WF6UK-4320975WF6-A2A-UK-432097
20.00Single6A94Zotepine6A94-5-HT2A-Zotepine
20.00Single6AQFZM2413856AQF-A2A-ZM241385
20.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
20.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
20.00Single6TPKRetosiban6TPK-OT-Retosiban
20.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
20.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
20.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
20.00Single7AROLUF58337ARO-A2A-LUF5833-Na
20.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
20.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
20.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
20.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7T32ZM2413857T32-A2A-ZM241385
20.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
20.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
20.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
20.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
20.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
20.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
20.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
20.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.00Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
20.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
20.00Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
20.00Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
20.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
20.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
20.00Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
20.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
19.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
19.35Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
19.35Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
19.35Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
19.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.35Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
19.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
19.35Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
19.35Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
19.23Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
19.23Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
19.23Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
19.23Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
19.23Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
19.23Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
19.05Single3EMLZM2413853EML-A2A-ZM241385
19.05Single4EIYZM2413854EIY-A2A-ZM241385-Na
19.05Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
19.05Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
19.05Single5DSGTiotropium5DSG-M4-Tiotropium
19.05Single5IU8Q274563475IU8-A2A-Q27456347-Na
19.05Single5K2AZM2413855K2A-A2A-ZM241385-Na
19.05Single5OLGZM2413855OLG-A2A-ZM241385-Na
19.05Single5T04Neurotensin5T04-NTS1-Neurotensin
19.05Single5UENDU1725UEN-A1-DU172
19.05Single5VRAZM2413855VRA-A2A-ZM241385-Na
19.05Single6LPJZM2413856LPJ-A2A-ZM241385-Na
19.05Single6LPKZM2413856LPK-A2A-ZM241385-Na
19.05Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
19.05Single6S0LZM2413856S0L-A2A-ZM241385
19.05Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
19.05Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
19.05Single7F83PF-051904577F83-Ghrelin-PF-05190457
19.05Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
19.05Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
19.05Single7PYRPSB-21157PYR-A2A-PSB-2115
19.05Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
19.05Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
19.05Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
19.05Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
19.05Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
19.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
19.05Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
19.05Consensusa2_offOrthosteric Liganda2a_off
19.05Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
19.05Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
19.05Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
19.05Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
19.05Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
18.75Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
18.75Single6LMLGlucagon6LML-Glucagon-Glucagon
18.75Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
18.75Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
18.75Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
18.75Single7WC4Serotonin7WC4-5-HT2A-Serotonin
18.75Single8PWNTheophylline8PWN-A2A-Theophylline
18.75Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.75Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.75Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.52Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
18.52Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
18.52Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
18.52Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.52Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
18.42Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
18.18Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
18.18Single5IUAQ274563485IUA-A2A-Q27456348-Na
18.18Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
18.18Single5N2SPSB365N2S-A1-PSB36
18.18Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
18.18Single6LPLZM2413856LPL-A2A-ZM241385-Na
18.18Single6LUQHaloperidol6LUQ-D2-Haloperidol
18.18Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
18.18Single6S0QZM2413856S0Q-A2A-ZM241385
18.18Single6WQAZM2413856WQA-A2A-ZM241385-Na
18.18Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
18.18Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
18.18Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
18.18Single7RM5ZM2413857RM5-A2A-ZM241385-Na
18.18Single7SINNPS-21437SIN-CaS-NPS-2143
18.18Single7SINNPS-21437SIN-CaS-NPS-2143
18.18Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
18.18Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
18.18Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
18.18Single8FYNZM2413858FYN-A2A-ZM241385-Na
18.18Single8GNEKW-63568GNE-A2A-KW-6356-Na
18.18Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
18.18Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
18.18Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
18.18Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
18.18Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
18.18Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single7XNACYN1548067XNA-SST2-CYN154806
17.86Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
17.86Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
17.86Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
17.65Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
17.65Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
17.65Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.65Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.65Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
17.65Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.65Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
17.65Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single5TZR-5TZR-FFA1 (GPR40)-MK8666
17.39Single5V56TC1145V56-SMO-TC114
17.39Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.39Single6OS1TRV0266OS1-AT1-TRV026
17.39Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
17.39Single7PX4PSB-21137PX4-A2A-PSB-2113
17.39Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
17.39Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
17.39Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
17.39Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
17.39Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
17.39Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
17.39Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
17.39Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
17.39Consensusrelaxin_onOrthosteric Ligandrxfp4_on
17.24Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.24Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
17.24Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Consensusclass-d_onOrthosteric Ligandste2_on
17.24Consensusgi_class-dOrthosteric Ligandgi_ste
17.24Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.24Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
17.24Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.14Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
17.14Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
17.14Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
16.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
16.67Single3UZAGTPL92363UZA-A2A-GTPL9236
16.67Single4N4WSANT-14N4W-SMO-SANT-1
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
16.67Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
16.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single6OS2TRV0266OS2-AT1-TRV026
16.67Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
16.67Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.67Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
16.67Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
16.67Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
16.67Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
16.67Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
16.67Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.67Single8GGZEpinephrine8GGZ-β2-Epinephrine
16.67Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
16.67Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
16.67Consensusclass-b2_onOrthosteric Ligandadgrg_on
16.67Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.67Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
16.67Consensusgi_class-fOther Ligandgi_frizzled
16.67Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.67Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
16.67Consensusnts_onOrthosteric Ligandnts1_on
16.67Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
16.67Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
16.22Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
16.22Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
16.13Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.13Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.13Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
16.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
16.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
16.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
16.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
16.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
16.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
16.00Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
16.00Consensuscyslt_offOrthosteric Ligandcyslt2_off
16.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
16.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
15.79Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
15.79Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
15.79Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
15.79Single6HLLCP999946HLL-NK1-CP99994
15.79Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
15.79Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
15.79Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
15.79Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.79Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
15.79Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.79Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.79Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
15.79Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
15.79Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
15.79Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
15.79Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensusclass-t_onOrthosteric Ligandtaste2_on
15.79Consensusgs_class-tOrthosteric Ligandgs_taste
15.79Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.79Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
15.79Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
15.79Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.79Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.62Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
15.62Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
15.38Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
15.38Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
15.38Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.38Single7XN9L-054,5227XN9-SST2-L-054,522
15.38Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
15.38Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
15.38Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
15.38Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Consensusgs_class-b2Orthosteric Ligandgs_adgr
15.15Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
15.15Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
15.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
15.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
15.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
15.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
15.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.00Consensusgt_class-aOrthosteric Ligandgt_opsin
15.00Consensusgt_opsinOrthosteric Ligandgt_sensory
15.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
14.81Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
14.81Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
14.81Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
14.81Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
14.71Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single5UVIZM2413855UVI-A2A-ZM241385
14.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.29Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
14.29Single6MH8ZM2413856MH8-A2A-ZM241385
14.29Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
14.29Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
14.29Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
14.29Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
14.29Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7SK5CXCL127SK5-ACKR3-CXCL12
14.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.29Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
14.29Single7VV6C48/807VV6-MRGPRX2-C48/80
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.29Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
14.29Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8K2WAMG4878K2W-CXCR3-AMG487
14.29Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
14.29Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.29Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
14.29Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
14.29Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
14.29Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
14.29Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
14.29Consensussst_offOrthosteric Ligandsst2_off
13.89Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
13.79Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
13.79Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
13.64Single6D27CAY104716D27-DP2-CAY10471
13.64Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.64Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
13.64Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
13.64Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.64Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.64Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.64Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
13.64Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
13.16Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.04Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
13.04Single4NTJAZD12834NTJ-P2Y12-AZD1283
13.04Single5CGCHTL142425CGC-mGlu5-HTL14242
13.04Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
13.04Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.04Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.04Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
13.04Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.04Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
13.04Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.90Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.50Single5MZPCaffeine5MZP-A2A-Caffeine-Na
12.50Single5V57TC1145V57-SMO-TC114
12.50Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.50Single6W25Ca6W25-MC4-SHU9119-Ca
12.50Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.50Single7P2L4YI7P2L-mGlu5-4YI
12.50Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.50Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
12.20Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
12.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
12.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
11.90Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
11.76Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
11.76Consensusclass-c_onOther Ligandgabab_on mglu_on
11.54Single5CGDHTL142425CGD-mGlu5-HTL14242
11.54Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
11.54Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
11.54Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
11.54Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
11.54Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single3RFMCaffeine3RFM-A2A-Caffeine
11.11Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.11Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.11Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
11.11Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.11Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
11.11Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
11.11Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
10.71Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
10.71Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
10.53Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
10.53Single4XNWMRS25004XNW-P2Y1-MRS2500
10.53Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
10.53Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.53Single6ME5Agomelatine6ME5-MT1-Agomelatine
10.53Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.53Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
10.53Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
10.53Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
10.53Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
10.53Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
10.53Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
10.53Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
10.53Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.53Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
10.53Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.53Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.34Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.00Single5L7IVismodegib5L7I-SMO-Vismodegib
10.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
10.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.00Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
10.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Consensusgo_proteinOrthosteric Ligandgo_chemokine
10.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.68Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.52Single4QINSAG1.54QIN-SMO-SAG1.5
9.52Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
9.52Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
9.52Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.52Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
9.52Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.52Consensusclass-f_offOrthosteric Ligandsmo_off
9.09Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.09Single6ZINSR486926ZIN-NTS1-SR48692
9.09Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
9.09Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.09Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8IYXYL-3658IYX-GPR34-YL-365
9.09Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.09Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.09Consensusgi_class-fOrthosteric Ligandgi_frizzled
9.09Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.82Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
8.70Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
8.70Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
8.70Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
8.70Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
8.70Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
8.57Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
8.33Single6Z4SSR486926Z4S-NTS1-SR48692
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.00Consensuschemerin_onOrthosteric Ligandcml1_on
8.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
7.69Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
7.69Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
7.69Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.69Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
7.69Consensusnts_offOrthosteric Ligandnts1_off
7.41Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.32Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.14Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.14Single6D35Cholesterol6D35-SMO-Cholesterol
7.14Single6KNMJN241-96KNM-Apelin-JN241-9
7.14Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.14Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.14Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
7.14Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
7.14Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.14Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.14Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.14Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
7.14Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
7.14Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.14Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
7.14Single7DTTCa7DTT-CaS-Ca-Ca
7.14Single7DTTCa7DTT-CaS-Ca-Ca
7.14Single7DTUTryptophan7DTU-CaS-Tryptophan
7.14Single7DTUTryptophan7DTU-CaS-Tryptophan
7.14Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.14Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.14Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
7.14Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
7.14Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.14Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.14Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.14Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.14Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.14Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.14Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.14Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single7FIIhCG7FII-LH-hCG-6fuf
7.14Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
7.14Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.14Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.14Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.14Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.14Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7.14Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
7.14Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.14Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.14Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.14Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.14Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.14Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.14Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
7.14Single7XW7K1-707XW7-TSH-K1-70
7.14Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.14Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.14Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.14Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.14Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.14Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.14Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.14Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.14Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.14Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.14Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.14Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.14Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
7.14Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.14Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.14Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.14Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.14Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.14Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.14Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.14Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.14Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.14Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.14Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.14Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.14Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.14Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.14Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.14Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.14Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.14Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.14Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.14Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
7.14Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
7.14Consensusclass-c_offOther Ligandgabab_off mglu_off
7.14Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
7.14Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
7.14Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.14Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.14Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.14Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
7.14Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
7.14Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.14Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.14Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.14Consensusgphr_onOrthosteric Ligandlh_on tsh_on
7.14Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
7.14Consensusgs_proteinOrthosteric Ligandgs_gphr
7.14Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
7.14Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
7.14Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
7.14Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.14Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.14Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
7.14Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
7.14Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.14Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.14Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
7.14Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
7.14Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
7.14Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
7.14Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
7.14Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
7.14Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
7.14Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
7.14Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.82Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7SHEPI; PE7SHE-GPR158-PI; PE
6.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
6.67Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
6.25Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
6.25Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
6.25Single8HS2Fab0468HS2-GPR20-Fab046
5.88Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
5.88Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.88Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.88Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.88Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
5.88Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.88Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.56Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
5.56Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
5.56Single5L7DCholesterol5L7D-SMO-Cholesterol
5.56Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
5.56Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.56Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.56Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
5.56Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.41Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.41Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
5.41Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.26Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
5.26Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.26Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.26Consensussensory_onOrthosteric Ligandopsin_on
5.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
5.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
5.00Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
5.00Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
5.00Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.00Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.76Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.76Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.76Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.76Consensusgo_class-b2Orthosteric Ligandgo_adhesion
4.55Single4XNVBPTU4XNV-P2Y1-BPTU
4.55Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.55Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.55Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.55Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.35Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.26Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.17Single6FFHFenobam6FFH-mGlu5-Fenobam
3.85Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.85Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.85Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.23Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.63Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.63Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.50Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.50Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.17Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3

PDB Summary
PDB 7EW2
Class A
SubFamily Lipid
Type Lysophospholipid (S1P)
SubType S1P3
Species Homo sapiens
Ligand Fingolimod
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.1
Date 2021-09-29
D.O.I. 10.1038/s41422-021-00567-w
Net Summary
Imin 1.86
Number of Linked Nodes 851
Number of Links 1118
Number of Hubs 198
Number of Links mediated by Hubs 734
Number of Communities 22
Number of Nodes involved in Communities 310
Number of Links involved in Communities 487
Path Summary
Number Of Nodes in MetaPath 100
Number Of Links MetaPath 99
Number of Shortest Paths 4560332
Length Of Smallest Path 3
Average Path Length 32.949
Length of Longest Path 57
Minimum Path Strength 1.28
Average Path Strength 5.03113
Maximum Path Strength 22.945
Minimum Path Correlation 0.7
Average Path Correlation 0.992251
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 37.9457
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.5219
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeJ89
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeJ89
Name(2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol
Synonyms
Identifier[(2~{S})-2-azanyl-2-(hydroxymethyl)-4-(4-octylphenyl)butyl] dihydrogen phosphate
FormulaC19 H34 N O5 P
Molecular Weight387.451
SMILESCCCCCCCCc1ccc(cc1)CC[C@](CO)(COP(=O)(O)O)N
PubChem11452022
Formal Charge0
Total Atoms60
Total Chiral Atoms1
Total Bonds60
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7EW2_Chain_A
GCTLSAEDK AAVERSKMI DRNLREDGE KAAREVKLL LLGAGESGK 
STIVKQMKI GIVETHFTF KDLHFKMFD VGGQRSERK KWIHCFEGV 
TAIIFCVAL SDYDLVLAE DEEMNRMHE SMKLFDSIC NNKWFTDTS 
IILFLNKKD LFEEKIKKS PLTICYPEY AGSNTYEEA AAYIQCQFE 
DLNKRKDTK EIYTHFTCA TDTKNVQFV FDAVTDVII KNNLKDCGL 
F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7EW2_Chain_B
GSELDQLRQ EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM 
RTRRTLRGH LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV 
HAIPLRSSW VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV 
SRELAGHTG YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF 
TGHTGDVMS LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH 
ESDINAICF FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII 
CGITSVSFS KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV 
SCLGVTDDG MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7EW2_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFREKKF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99500
Sequence
>7EW2_Chain_R
ETLREHYQY VGKLAGRST LTTVLFLVI CSFIVLENL MVLIAIWKN 
NKFHNRMYF FIGNLALCD LLAGIAYKV NILMSGKKT FSLSPTVWF 
LREGSMFVA LGASTCSLL AIAIERHLT MIKMRPYDA NKRHRVFLL 
IGMCWLIAF TLGALPILG WNCLHNLPD CSTILPLYS KKYIAFCIS 
IFTAILVTI VILYARIYF LVKSSSRKV ANHNNSERS MALLRTVVI 
VVSVFIACW SPLFILFLI DVACRVQAC PILFKAQWF IVLAVLNSA 
MNPVIYTLA SKEMRRAFF RL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
s1p3_on7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
gi_lpl7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7C4SALipidLysophospholipid (S1P)S1P3Homo sapiensS1P--3.22021-06-0910.1126/sciadv.abf5325
7EW3ALipidLysophospholipid (S1P)S1P3Homo sapiensS1P-Gi1/&β;1/&γ;23.12021-09-2910.1038/s41422-021-00567-w
7EW4ALipidLysophospholipid (S1P)S1P3Homo sapiensCYM5541-Gi1/&β;1/&γ;23.22021-09-2910.1038/s41422-021-00567-w




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