psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y22	3.55	Yes	No	0	0	9
2	L:L:?1	R:R:R31	8.28	Yes	No	0	0	4
3	L:L:?1	R:R:N95	8.32	Yes	No	1	0	6
4	L:L:?1	R:R:S99	7.96	Yes	No	1	0	5
5	L:L:?1	R:R:T103	3.35	Yes	No	1	0	5
6	L:L:?1	R:R:R114	2.76	Yes	Yes	1	0	6
7	L:L:?1	R:R:E115	9.04	Yes	Yes	1	0	5
8	L:L:?1	R:R:F119	4.61	Yes	No	0	0	5
9	L:L:?1	R:R:L122	12.58	Yes	No	0	0	6
10	L:L:?1	R:R:F260	4.61	Yes	Yes	1	0	6
11	L:L:?1	R:R:I284	5.41	Yes	No	0	0	5
12	R:R:E16	R:R:R19	3.49	No	No	0	4	1
13	R:R:H21	R:R:T17	5.48	Yes	No	0	7	6
14	R:R:L18	R:R:P108	3.28	No	No	0	7	3
15	R:R:F104	R:R:R19	24.59	No	No	0	7	1
16	R:R:E20	R:R:L182	3.98	No	Yes	0	2	3
17	R:R:C178	R:R:H21	2.95	No	Yes	0	5	7
18	R:R:H21	R:R:L179	5.14	Yes	No	1	7	3
19	R:R:H21	R:R:L182	2.57	Yes	Yes	1	7	3
20	R:R:H21	R:R:L191	10.29	Yes	Yes	1	7	4
21	R:R:K27	R:R:Y22	3.58	No	No	0	7	9
22	R:R:P190	R:R:Y22	12.52	No	No	0	4	9
23	R:R:L28	R:R:Q23	3.99	No	No	0	3	7
24	R:R:L182	R:R:Y24	9.38	Yes	No	1	3	5
25	R:R:P183	R:R:Y24	2.78	No	No	1	4	5
26	R:R:T187	R:R:V25	4.76	No	No	0	5	6
27	R:R:F278	R:R:K27	3.72	No	No	0	1	7
28	R:R:F104	R:R:R31	5.34	No	No	0	7	4
29	R:R:F46	R:R:T42	5.19	No	No	0	7	5
30	R:R:L47	R:R:T43	2.95	No	No	0	5	6
31	R:R:I49	R:R:L45	2.85	No	No	0	7	4
32	R:R:K93	R:R:L47	5.64	No	No	0	6	5
33	R:R:S51	R:R:V48	3.23	No	No	0	4	4
34	R:R:C50	R:R:Y92	4.03	No	Yes	0	6	6
35	R:R:C50	R:R:K93	4.85	No	No	0	6	6
36	R:R:I53	R:R:N57	2.83	No	Yes	3	7	9
37	R:R:D85	R:R:I53	4.2	No	No	3	9	7
38	R:R:A292	R:R:I53	6.5	No	No	0	6	7
39	R:R:L86	R:R:V54	4.47	No	No	0	7	6
40	R:R:I90	R:R:V54	3.07	No	No	0	5	6
41	R:R:E56	R:R:P295	6.29	No	No	0	8	9
42	R:R:E56	R:R:V296	4.28	No	No	0	8	6
43	R:R:D85	R:R:N57	13.46	No	Yes	3	9	9
44	R:R:L86	R:R:N57	2.75	No	Yes	0	7	9
45	R:R:N57	R:R:P295	6.52	Yes	No	0	9	9
46	R:R:I62	R:R:L58	2.85	No	No	0	4	4
47	R:R:F309	R:R:M59	6.22	No	No	0	6	7
48	R:R:I64	R:R:V60	3.07	No	No	0	8	9
49	R:R:P295	R:R:V60	3.53	No	No	0	9	9
50	R:R:L61	R:R:L83	2.77	No	No	0	7	6
51	R:R:A63	R:R:F309	5.55	No	No	0	7	6
52	R:R:I64	R:R:I78	2.94	No	No	0	8	8
53	R:R:K66	R:R:L312	11.28	No	No	0	5	6
54	R:R:L312	R:R:N67	5.49	No	No	0	6	7
55	R:R:H71	R:R:K69	5.24	No	No	0	8	6
56	R:R:F70	R:R:Y75	13.41	No	No	0	8	9
57	R:R:F70	R:R:F76	5.36	No	No	0	8	4
58	R:R:M74	R:R:N72	5.61	No	No	0	8	7
59	R:R:E135	R:R:R73	6.98	Yes	Yes	0	9	5
60	R:R:R153	R:R:R73	6.4	No	Yes	0	5	5
61	R:R:R73	R:R:V154	3.92	Yes	Yes	0	5	7
62	R:R:E135	R:R:M74	5.41	Yes	No	0	9	8
63	R:R:E304	R:R:Y75	6.73	No	No	4	7	9
64	R:R:M305	R:R:Y75	4.79	No	No	4	8	9
65	R:R:F76	R:R:V154	3.93	No	Yes	0	4	7
66	R:R:A131	R:R:F77	2.77	No	Yes	0	7	8
67	R:R:F77	R:R:I132	5.02	Yes	No	0	8	9
68	R:R:E135	R:R:F77	8.16	Yes	Yes	0	9	8
69	R:R:F77	R:R:V154	7.87	Yes	Yes	0	8	7
70	R:R:F77	R:R:L157	3.65	Yes	No	0	8	6
71	R:R:C84	R:R:N80	4.72	No	No	2	8	9
72	R:R:N80	R:R:S128	4.47	No	No	0	9	8
73	R:R:N80	R:R:W162	5.65	No	Yes	2	9	9
74	R:R:L81	R:R:S128	7.51	No	No	0	9	8
75	R:R:L129	R:R:L81	4.15	No	No	0	9	9
76	R:R:L83	R:R:L87	2.77	No	No	0	6	7
77	R:R:A124	R:R:C84	3.61	No	No	2	8	8
78	R:R:C84	R:R:W162	3.92	No	Yes	2	8	9
79	R:R:D85	R:R:S291	7.36	No	No	0	9	9
80	R:R:M118	R:R:Y92	7.18	No	Yes	0	6	6
81	R:R:I284	R:R:Y92	3.63	No	Yes	0	5	6
82	R:R:V288	R:R:Y92	8.83	No	Yes	0	7	6
83	R:R:M98	R:R:V94	3.04	No	No	0	4	7
84	R:R:N95	R:R:S99	2.98	No	No	1	6	5
85	R:R:N95	R:R:R114	8.44	No	Yes	1	6	6
86	R:R:R114	R:R:S99	9.22	Yes	No	1	6	5
87	R:R:R114	R:R:T103	5.17	Yes	No	1	6	5
88	R:R:L106	R:R:V110	7.45	No	No	0	6	6
89	R:R:P108	R:R:S107	3.56	No	No	0	3	7
90	R:R:S107	R:R:V110	4.85	No	No	0	7	6
91	R:R:F112	R:R:W111	5.01	Yes	Yes	1	6	9
92	R:R:R114	R:R:W111	9	Yes	Yes	1	6	9
93	R:R:E115	R:R:W111	18.54	Yes	Yes	1	5	9
94	R:R:P190	R:R:W111	2.7	No	Yes	0	4	9
95	R:R:L191	R:R:W111	7.97	Yes	Yes	1	4	9
96	R:R:W111	R:R:Y192	2.89	Yes	Yes	1	9	3
97	R:R:F112	R:R:I173	7.54	Yes	No	0	6	5
98	R:R:F112	R:R:N177	12.08	Yes	No	0	6	5
99	R:R:F112	R:R:L191	4.87	Yes	Yes	1	6	4
100	R:R:F112	R:R:Y192	5.16	Yes	Yes	1	6	3
101	R:R:E115	R:R:R114	3.49	Yes	Yes	1	5	6
102	R:R:E115	R:R:L189	3.98	Yes	No	1	5	5
103	R:R:E115	R:R:Y192	4.49	Yes	Yes	1	5	3
104	R:R:F119	R:R:Y196	8.25	No	Yes	0	5	6
105	R:R:F166	R:R:V120	2.62	No	No	0	4	5
106	R:R:A124	R:R:W162	3.89	No	Yes	2	8	9
107	R:R:S125	R:R:S291	3.26	No	No	0	9	9
108	R:R:T126	R:R:W256	4.85	No	Yes	0	7	8
109	R:R:L129	R:R:Y298	7.03	No	Yes	0	9	9
110	R:R:I134	R:R:L130	2.85	No	Yes	0	7	7
111	R:R:I207	R:R:L130	7.14	No	Yes	5	7	7
112	R:R:L130	R:R:T210	2.95	Yes	No	0	7	6
113	R:R:I211	R:R:L130	4.28	No	Yes	5	8	7
114	R:R:I132	R:R:R136	6.26	No	No	0	9	9
115	R:R:I132	R:R:Y298	4.84	No	Yes	0	9	9
116	R:R:A133	R:R:L214	3.15	No	Yes	0	8	6
117	R:R:A133	R:R:Y215	5.34	No	Yes	0	8	9
118	R:R:I134	R:R:L157	4.28	No	No	0	7	6
119	R:R:I134	R:R:L214	2.85	No	Yes	0	7	6
120	R:R:E135	R:R:T139	5.64	Yes	No	0	9	8
121	R:R:H137	R:R:L214	7.71	No	Yes	0	8	6
122	R:R:H137	R:R:R217	4.51	No	No	0	8	6
123	R:R:L138	R:R:R153	4.86	No	No	0	5	5
124	R:R:I141	R:R:K142	2.91	No	No	0	6	5
125	R:R:K142	R:R:R144	4.95	No	No	0	5	6
126	R:R:P145	R:R:Y146	4.17	No	No	0	5	7
127	R:R:K150	R:R:R153	14.85	No	No	0	7	5
128	R:R:F155	R:R:R151	3.21	No	Yes	0	1	2
129	R:R:I158	R:R:V154	3.07	No	Yes	0	7	7
130	R:R:I164	R:R:M160	2.92	No	No	0	3	3
131	R:R:C161	R:R:W162	2.61	No	Yes	0	7	9
132	R:R:F166	R:R:W162	3.01	No	Yes	0	4	9
133	R:R:L168	R:R:Y196	5.86	No	Yes	0	5	6
134	R:R:L171	R:R:P172	3.28	No	No	1	6	5
135	R:R:L171	R:R:W176	7.97	No	No	1	6	4
136	R:R:L171	R:R:Y196	4.69	No	Yes	1	6	6
137	R:R:P172	R:R:Y192	9.74	No	Yes	1	5	3
138	R:R:P172	R:R:Y196	13.91	No	Yes	1	5	6
139	R:R:W176	R:R:Y196	3.86	No	Yes	1	4	6
140	R:R:L179	R:R:N177	4.12	No	No	0	3	5
141	R:R:C178	R:R:C185	7.28	No	No	0	5	9
142	R:R:L179	R:R:L191	2.77	No	Yes	1	3	4
143	R:R:N181	R:R:P183	6.52	No	No	0	3	4
144	R:R:D184	R:R:N181	14.81	No	No	0	3	3
145	R:R:L182	R:R:P183	3.28	Yes	No	1	3	4
146	R:R:K194	R:R:S186	3.06	No	No	0	3	5
147	R:R:I197	R:R:S186	3.1	Yes	No	0	6	5
148	R:R:D266	R:R:S186	5.89	Yes	No	0	4	5
149	R:R:D266	R:R:T187	5.78	Yes	No	1	4	5
150	R:R:L277	R:R:T187	7.37	Yes	No	1	2	5
151	R:R:I188	R:R:L189	2.85	Yes	No	1	4	5
152	R:R:D266	R:R:I188	8.4	Yes	Yes	1	4	4
153	R:R:I188	R:R:L277	4.28	Yes	Yes	1	4	2
154	R:R:L189	R:R:Y192	8.21	No	Yes	1	5	3
155	R:R:K195	R:R:S193	6.12	No	No	0	4	5
156	R:R:C200	R:R:Y196	6.72	No	Yes	0	6	6
157	R:R:I197	R:R:I201	2.94	Yes	Yes	1	6	4
158	R:R:I197	R:R:V267	3.07	Yes	No	0	6	4
159	R:R:F199	R:R:I203	7.54	No	No	0	4	5
160	R:R:F260	R:R:I201	3.77	Yes	Yes	1	6	4
161	R:R:I201	R:R:L264	4.28	Yes	No	0	4	5
162	R:R:F204	R:R:W256	6.01	No	Yes	1	7	8
163	R:R:F204	R:R:F260	35.37	No	Yes	1	7	6
164	R:R:I207	R:R:I211	2.94	No	No	5	7	8
165	R:R:F252	R:R:L208	3.65	No	No	0	9	6
166	R:R:I253	R:R:L208	2.85	No	No	0	6	6
167	R:R:L214	R:R:T210	2.95	Yes	No	0	6	6
168	R:R:I211	R:R:Y215	3.63	No	Yes	0	8	9
169	R:R:V248	R:R:Y215	3.79	No	Yes	0	8	9
170	R:R:V249	R:R:Y215	3.79	No	Yes	0	8	9
171	R:R:Y215	R:R:Y298	4.96	Yes	Yes	0	9	9
172	R:R:F220	R:R:Y219	4.13	No	Yes	0	1	6
173	R:R:K223	R:R:Y219	4.78	No	Yes	6	5	6
174	R:R:S238	R:R:Y219	5.09	No	Yes	6	7	6
175	R:R:L242	R:R:Y219	10.55	No	Yes	0	7	6
176	R:R:L241	R:R:V222	4.47	No	Yes	0	8	8
177	R:R:K223	R:R:R227	3.71	No	No	0	5	4
178	R:R:K223	R:R:S238	7.65	No	No	6	5	7
179	R:R:N234	R:R:S226	7.45	Yes	No	7	4	5
180	R:R:R237	R:R:S226	2.64	No	No	7	4	5
181	R:R:N234	R:R:V229	2.96	Yes	No	0	4	7
182	R:R:N231	R:R:N234	5.45	No	Yes	0	5	4
183	R:R:E236	R:R:N233	3.94	No	No	0	4	4
184	R:R:N234	R:R:R237	4.82	Yes	No	7	4	4
185	R:R:M239	R:R:R243	4.96	No	No	0	5	7
186	R:R:L242	R:R:V246	2.98	No	No	0	7	6
187	R:R:I253	R:R:V249	3.07	No	No	0	6	8
188	R:R:I297	R:R:V251	4.61	No	No	0	8	6
189	R:R:F252	R:R:W256	4.01	No	Yes	0	9	8
190	R:R:C255	R:R:N290	7.87	No	No	0	9	9
191	R:R:F260	R:R:W256	5.01	Yes	Yes	1	6	8
192	R:R:A287	R:R:W256	7.78	No	Yes	0	7	8
193	R:R:N290	R:R:W256	6.78	No	Yes	0	9	8
194	R:R:P258	R:R:S257	3.56	No	No	0	9	5
195	R:R:I261	R:R:S257	3.1	No	No	0	4	5
196	R:R:F283	R:R:P258	2.89	No	No	0	6	9
197	R:R:L286	R:R:P258	4.93	No	No	0	7	9
198	R:R:F263	R:R:L259	7.31	Yes	No	0	6	6
199	R:R:I261	R:R:I265	2.94	No	No	0	4	4
200	R:R:L262	R:R:L277	2.77	No	Yes	0	5	2
201	R:R:F283	R:R:L262	4.87	No	No	0	6	5
202	R:R:D266	R:R:L277	14.93	Yes	Yes	1	4	2
203	R:R:C269	R:R:C274	7.28	No	No	8	4	2
204	R:R:I276	R:R:K279	2.91	No	Yes	0	4	4
205	R:R:K279	R:R:W282	3.48	Yes	No	0	4	4
206	R:R:Q281	R:R:W282	5.48	No	No	0	4	4
207	R:R:N290	R:R:N294	10.9	No	No	0	9	9
208	R:R:L300	R:R:T299	2.95	No	No	0	5	7
209	R:R:M305	R:R:S302	3.07	No	No	0	8	8
210	R:R:K303	R:R:R307	9.9	No	No	0	5	4
211	R:R:E304	R:R:M305	2.71	No	No	4	7	8
212	R:R:R306	R:R:R307	4.26	No	No	0	8	4
213	R:R:F310	R:R:R306	4.28	No	No	0	4	8
214	R:R:F263	R:R:I188	2.51	Yes	Yes	1	6	4
215	R:R:F263	R:R:I197	2.51	Yes	Yes	1	6	6
216	R:R:F263	R:R:I201	2.51	Yes	Yes	1	6	4
217	R:R:I213	R:R:R217	2.51	No	No	0	4	6
218	R:R:M98	R:R:R114	2.48	No	Yes	0	4	6
219	R:R:F278	R:R:K279	2.48	No	Yes	0	1	4
220	R:R:F104	R:R:L28	2.44	No	No	0	7	3
221	R:R:F199	R:R:L168	2.44	No	No	0	4	5
222	R:R:F309	R:R:L300	2.44	No	No	0	6	5
223	R:R:L312	R:R:R311	2.43	No	No	0	6	4
224	R:R:I78	R:R:Y298	2.42	No	Yes	0	8	9
225	R:R:N149	R:R:R151	2.41	No	Yes	0	4	2
226	R:R:D147	R:R:R73	2.38	No	Yes	0	3	5
227	R:R:F46	R:R:Q281	2.34	No	No	0	7	4
228	R:R:L241	R:R:Y219	2.34	No	Yes	0	8	6
229	R:R:E56	R:R:F52	2.33	No	No	0	8	4
230	R:R:A82	R:R:G79	1.95	No	No	0	9	6
231	R:R:A88	R:R:G89	1.95	No	No	0	8	7
232	R:R:A165	R:R:G123	1.95	No	No	0	8	5
233	R:R:C274	R:R:P275	1.88	No	No	0	2	2
234	R:R:G26	R:R:V25	1.84	No	No	0	6	6
235	R:R:G169	R:R:V120	1.84	No	No	0	7	5
236	R:R:C127	R:R:C161	1.82	No	No	0	5	7
237	R:R:A273	R:R:C269	1.81	No	No	8	3	4
238	R:R:A273	R:R:C274	1.81	No	No	8	3	2
239	R:R:A121	R:R:A88	1.79	No	No	0	7	8
240	R:R:A121	R:R:A91	1.79	No	No	0	7	5
241	R:R:A124	R:R:A165	1.79	No	No	0	8	8
242	R:R:G79	R:R:I64	1.76	No	No	0	6	8
243	R:R:G159	R:R:I158	1.76	No	No	0	3	7
244	R:R:P108	R:R:T17	1.75	No	No	0	3	6
245	R:R:G79	R:R:L61	1.71	No	No	0	6	7
246	R:R:G175	R:R:N177	1.7	No	No	0	5	5
247	R:R:K279	R:R:P275	1.67	Yes	No	0	4	2
248	R:R:G26	R:R:Q272	1.64	No	No	0	6	1
249	R:R:C50	R:R:I49	1.64	No	No	0	6	7
250	R:R:A280	R:R:I188	1.62	No	Yes	0	4	4
251	R:R:S226	R:R:V222	1.62	No	Yes	0	5	8
252	R:R:C255	R:R:M293	1.62	No	No	0	9	7
253	R:R:A91	R:R:M118	1.61	No	No	0	5	6
254	R:R:V44	R:R:V48	1.6	No	No	0	5	4
255	R:R:S107	R:R:T109	1.6	No	No	0	7	1
256	R:R:V245	R:R:V249	1.6	No	No	0	8	8
257	R:R:T299	R:R:V60	1.59	No	No	0	7	9
258	R:R:T244	R:R:V248	1.59	No	No	0	9	8
259	R:R:A292	R:R:L289	1.58	No	No	0	6	5
260	R:R:A308	R:R:N67	1.56	No	No	0	6	7
261	R:R:I49	R:R:V285	1.54	No	No	0	7	4
262	R:R:I213	R:R:V209	1.54	No	No	0	4	2
263	R:R:I253	R:R:V212	1.54	No	No	0	6	4
264	R:R:I218	R:R:V222	1.54	No	Yes	0	8	8
265	R:R:I247	R:R:V251	1.54	No	No	0	7	6
266	R:R:I297	R:R:V248	1.54	No	No	0	8	8
267	R:R:K102	R:R:S105	1.53	No	No	0	3	3
268	R:R:M239	R:R:S235	1.53	No	No	0	5	4
269	R:R:M140	R:R:V222	1.52	No	Yes	0	9	8
270	R:R:F119	R:R:G116	1.51	No	No	0	5	6
271	R:R:L106	R:R:S105	1.5	No	No	0	6	3
272	R:R:L221	R:R:S225	1.5	No	No	0	5	7
273	R:R:L41	R:R:T42	1.47	No	No	0	4	5
274	R:R:K142	R:R:K150	1.44	No	No	0	5	7
275	R:R:P145	R:R:R144	1.44	No	No	0	5	6
276	R:R:I96	R:R:L47	1.43	No	No	0	6	5
277	R:R:I96	R:R:L97	1.43	No	No	0	6	5
278	R:R:I173	R:R:L174	1.43	No	No	0	5	4
279	R:R:L156	R:R:M160	1.41	No	No	0	2	3
280	R:R:K69	R:R:N68	1.4	No	No	0	6	6
281	R:R:L58	R:R:L86	1.38	No	No	0	4	7
282	R:R:A273	R:R:R270	1.38	No	No	0	3	1
283	R:R:N233	R:R:N234	1.36	No	Yes	0	4	4
284	R:R:H137	R:R:I218	1.33	No	No	0	8	8
285	R:R:E236	R:R:H232	1.23	No	No	0	4	3
286	R:R:R151	R:R:R73	1.07	Yes	Yes	0	2	5
287	R:R:F76	R:R:R151	1.07	No	Yes	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.40636	11	1	0
2	R:R:H21	5.286	5	1	7
3	R:R:N57	6.39	4	3	9
4	R:R:R73	4.15	5	0	5
5	R:R:F77	5.494	5	0	8
6	R:R:Y92	5.9175	4	0	6
7	R:R:W111	7.685	6	1	9
8	R:R:F112	6.932	5	1	6
9	R:R:R114	5.79429	7	1	6
10	R:R:E115	7.908	5	1	5
11	R:R:L130	4.305	4	5	7
12	R:R:E135	6.5475	4	0	9
13	R:R:R151	1.94	4	0	2
14	R:R:V154	4.6975	4	0	7
15	R:R:W162	3.816	5	2	9
16	R:R:L182	4.8025	4	1	3
17	R:R:I188	3.932	5	1	4
18	R:R:L191	6.475	4	1	4
19	R:R:Y192	6.098	5	1	3
20	R:R:Y196	7.215	6	1	6
21	R:R:I197	2.905	4	1	6
22	R:R:I201	3.375	4	1	4
23	R:R:L214	4.165	4	0	6
24	R:R:Y215	4.302	5	0	9
25	R:R:Y219	5.378	5	6	6
26	R:R:V222	2.2875	4	0	8
27	R:R:N234	4.408	5	7	4
28	R:R:W256	5.74	6	1	8
29	R:R:F260	12.19	4	1	6
30	R:R:F263	3.71	4	1	6
31	R:R:D266	8.75	4	1	4
32	R:R:L277	7.3375	4	1	2
33	R:R:K279	2.635	4	0	4
34	R:R:Y298	4.8125	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R114	23.7779	2.76	Yes	Yes	1	0	6
2	R:R:R114	R:R:W111	21.8517	9	Yes	Yes	1	6	9
3	R:R:L191	R:R:W111	40.3507	7.97	Yes	Yes	1	4	9
4	R:R:H21	R:R:L191	39.7374	10.29	Yes	Yes	1	7	4
5	L:L:?1	R:R:E115	32.1688	9.04	Yes	Yes	1	0	5
6	R:R:E115	R:R:W111	23.6689	18.54	Yes	Yes	1	5	9
7	R:R:H21	R:R:T17	20.3571	5.48	Yes	No	0	7	6
8	R:R:P108	R:R:T17	18.131	1.75	No	No	0	3	6
9	R:R:H21	R:R:L182	13.6516	2.57	Yes	Yes	1	7	3
10	L:L:?1	R:R:Y22	15.6687	3.55	Yes	No	0	0	9
11	R:R:K27	R:R:Y22	15.7142	3.58	No	No	0	7	9
12	R:R:I188	R:R:L189	13.6744	2.85	Yes	No	1	4	5
13	R:R:I188	R:R:L277	15.7687	4.28	Yes	Yes	1	4	2
14	R:R:T187	R:R:V25	10.0945	4.76	No	No	0	5	6
15	R:R:F278	R:R:K27	14.6284	3.72	No	No	0	1	7
16	R:R:F278	R:R:K279	13.6607	2.48	No	Yes	0	1	4
17	L:L:?1	R:R:I284	21.3883	5.41	Yes	No	0	0	5
18	R:R:I284	R:R:Y92	20.2026	3.63	No	Yes	0	5	6
19	R:R:C50	R:R:Y92	11.6482	4.03	No	Yes	0	6	6
20	L:L:?1	R:R:F260	81.769	4.61	Yes	Yes	1	0	6
21	R:R:F260	R:R:W256	99.7138	5.01	Yes	Yes	1	6	8
22	R:R:F252	R:R:W256	100	4.01	No	Yes	0	9	8
23	R:R:F252	R:R:L208	99.9091	3.65	No	No	0	9	6
24	R:R:I253	R:R:L208	99.8092	2.85	No	No	0	6	6
25	R:R:I253	R:R:V249	99.582	3.07	No	No	0	6	8
26	R:R:V249	R:R:Y215	99.3186	3.79	No	Yes	0	8	9
27	R:R:Y215	R:R:Y298	79.6429	4.96	Yes	Yes	0	9	9
28	R:R:I78	R:R:Y298	35.4352	2.42	No	Yes	0	8	9
29	R:R:I64	R:R:I78	34.3404	2.94	No	No	0	8	8
30	R:R:I64	R:R:V60	27.5804	3.07	No	No	0	8	9
31	R:R:P295	R:R:V60	20.4934	3.53	No	No	0	9	9
32	R:R:N57	R:R:P295	15.587	6.52	Yes	No	0	9	9
33	R:R:I132	R:R:Y298	46.6019	4.84	No	Yes	0	9	9
34	R:R:F77	R:R:I132	45.0209	5.02	Yes	No	0	8	9
35	R:R:F77	R:R:V154	28.7207	7.87	Yes	Yes	0	8	7
36	R:R:F76	R:R:V154	10.8214	3.93	No	Yes	0	4	7
37	R:R:E135	R:R:F77	19.5257	8.16	Yes	Yes	0	9	8
38	R:R:E135	R:R:R73	15.1872	6.98	Yes	Yes	0	9	5
39	R:R:R73	R:R:V154	15.378	3.92	Yes	Yes	0	5	7
40	R:R:R153	R:R:R73	19.0214	6.4	No	Yes	0	5	5
41	R:R:L129	R:R:Y298	21.6882	7.03	No	Yes	0	9	9
42	R:R:L129	R:R:L81	20.4934	4.15	No	No	0	9	9
43	R:R:L81	R:R:S128	19.2804	7.51	No	No	0	9	8
44	R:R:N80	R:R:S128	18.0583	4.47	No	No	0	9	8
45	R:R:N80	R:R:W162	11.6482	5.65	No	Yes	2	9	9
46	R:R:P108	R:R:S107	13.6516	3.56	No	No	0	3	7
47	R:R:A133	R:R:Y215	27.7939	5.34	No	Yes	0	8	9
48	R:R:A133	R:R:L214	26.9126	3.15	No	Yes	0	8	6
49	R:R:H137	R:R:L214	28.8025	7.71	No	Yes	0	8	6
50	R:R:K150	R:R:R153	14.4376	14.85	No	No	0	7	5
51	R:R:K142	R:R:K150	12.0162	1.44	No	No	0	5	7
52	R:R:F260	R:R:I201	24.4049	3.77	Yes	Yes	1	6	4
53	R:R:H137	R:R:I218	24.0778	1.33	No	No	0	8	8
54	R:R:I218	R:R:V222	22.883	1.54	No	Yes	0	8	8
55	R:R:L241	R:R:V222	10.5034	4.47	No	Yes	0	8	8
56	R:R:S226	R:R:V222	10.5124	1.62	No	Yes	0	5	8
57	R:R:F263	R:R:I201	14.8555	2.51	Yes	Yes	1	6	4
58	R:R:F263	R:R:I188	14.6556	2.51	Yes	Yes	1	6	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y22	3.55	1	Yes	No	0	9	0	1
L:L:?1	R:R:R31	8.28	1	Yes	No	0	4	0	1
L:L:?1	R:R:N95	8.32	1	Yes	No	0	6	0	1
L:L:?1	R:R:S99	7.96	1	Yes	No	0	5	0	1
L:L:?1	R:R:T103	3.35	1	Yes	No	0	5	0	1
L:L:?1	R:R:R114	2.76	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:E115	9.04	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F119	4.61	1	Yes	No	0	5	0	1
L:L:?1	R:R:L122	12.58	1	Yes	No	0	6	0	1
L:L:?1	R:R:F260	4.61	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:I284	5.41	1	Yes	No	0	5	0	1
R:R:K27	R:R:Y22	3.58	0	No	No	7	9	2	1
R:R:P190	R:R:Y22	12.52	0	No	No	4	9	2	1
R:R:F104	R:R:R31	5.34	0	No	No	7	4	2	1
R:R:I284	R:R:Y92	3.63	0	No	Yes	5	6	1	2
R:R:N95	R:R:S99	2.98	1	No	No	6	5	1	1
R:R:N95	R:R:R114	8.44	1	No	Yes	6	6	1	1
R:R:R114	R:R:S99	9.22	1	Yes	No	6	5	1	1
R:R:R114	R:R:T103	5.17	1	Yes	No	6	5	1	1
R:R:R114	R:R:W111	9	1	Yes	Yes	6	9	1	2
R:R:E115	R:R:W111	18.54	1	Yes	Yes	5	9	1	2
R:R:P190	R:R:W111	2.7	0	No	Yes	4	9	2	2
R:R:W111	R:R:Y192	2.89	1	Yes	Yes	9	3	2	2
R:R:E115	R:R:R114	3.49	1	Yes	Yes	5	6	1	1
R:R:E115	R:R:L189	3.98	1	Yes	No	5	5	1	2
R:R:E115	R:R:Y192	4.49	1	Yes	Yes	5	3	1	2
R:R:F119	R:R:Y196	8.25	0	No	Yes	5	6	1	2
R:R:L189	R:R:Y192	8.21	1	No	Yes	5	3	2	2
R:R:F260	R:R:I201	3.77	1	Yes	Yes	6	4	1	2
R:R:F204	R:R:W256	6.01	1	No	Yes	7	8	2	2
R:R:F204	R:R:F260	35.37	1	No	Yes	7	6	2	1
R:R:F260	R:R:W256	5.01	1	Yes	Yes	6	8	1	2
R:R:M98	R:R:R114	2.48	0	No	Yes	4	6	2	1
R:R:F119	R:R:G116	1.51	0	No	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EW3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.57
Number of Linked Nodes	260
Number of Links	287
Number of Hubs	34
Number of Links mediated by Hubs	134
Number of Communities	8
Number of Nodes involved in Communities	52
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	41021
Length Of Smallest Path	3
Average Path Length	14.285
Length of Longest Path	30
Minimum Path Strength	1.43
Average Path Strength	4.78588
Maximum Path Strength	19.99
Minimum Path Correlation	0.7
Average Path Correlation	0.925698
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	47.0621
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.2675
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	S1P
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	S1P
Name	(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
Synonyms	sphingosine 1-phosphate
Identifier
Formula	C18 H38 N O5 P
Molecular Weight	379.472
SMILES
PubChem	5283560
Formal Charge	0
Total Atoms	63
Total Chiral Atoms	2
Total Bonds	62
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99500
Sequence	>7EW3_nogp_Chain_R E T L R E H Y Q Y V G K L A G R S T L T T V L F L V I C S F I V L E N L M V L I A I W K N N K F H N R M Y F F I G N L A L C D L L A G I A Y K V N I L M S G K K T F S L S P T V W F L R E G S M F V A L G A S T C S L L A I A I E R H L T M I K M R P Y D A N K R H R V F L L I G M C W L I A F T L G A L P I L G W N C L H N L P D C S T I L P L Y S K K Y I A F C I S I F T A I L V T I V I L Y A R I Y F L V K S S S R K V A N H N N S E R S M A L L R T V V I V V S V F I A C W S P L F I L F L I D V A C R V Q A C P I L F K A Q W F I V L A V L N S A M N P V I Y T L A S K E M R R A F F R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7C4S	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	-	3.2	2021-06-09	doi.org/10.1126/sciadv.abf5325
	7EW2	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	FTY720-P	-		3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW3	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	Gi1/β1/γ2	3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-		3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW4	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	CYM-5541	-	Gi1/β1/γ2	3.2	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	CYM-5541	-		3.2	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	9L74	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P d16:1	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.73	2025-11-26	10.1073/pnas.2507421122
	9L74 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P d16:1	-		3.73	2025-11-26	10.1073/pnas.2507421122
	9WP9	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2025-11-26	10.1073/pnas.2507421122
	9WP9 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-		3.25	2025-11-26	10.1073/pnas.2507421122

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EW3_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.