Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 7.108671510
2R:R:H21 5.6025407
3R:R:Y22 7.2775419
4R:R:V25 4.3025406
5R:R:I53 2.295407
6R:R:M74 5.208508
7R:R:F76 5.595404
8R:R:F77 6.46508
9R:R:N80 5.116569
10R:R:D85 7.72409
11R:R:Y92 3.78667616
12R:R:N95 8.034516
13R:R:S99 7.9875415
14R:R:F104 7.31833617
15R:R:W111 10.1375419
16R:R:F112 5.778516
17R:R:R114 5.85516
18R:R:E115 6.07515
19R:R:F119 4.598515
20R:R:E135 7.225409
21R:R:R153 6.5225405
22R:R:W162 3.684569
23R:R:L182 7.7125453
24R:R:T187 4.145435
25R:R:Y192 6.7513
26R:R:Y196 8.638516
27R:R:I207 3.6575407
28R:R:Y215 3.7775429
29R:R:Y219 6.31576
30R:R:N234 5.7375404
31R:R:W256 6.30714718
32R:R:F260 11.414516
33R:R:D266 7.6825434
34R:R:C274 3.156532
35R:R:N294 5.125429
36R:R:Y298 4.71333629
37R:R:E304 3.695447
38R:R:M305 3.70333648
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:R114 21.31916.35YesYes106
2R:R:R114 R:R:W111 23.01868YesYes169
3R:R:L191 R:R:W111 20.213317.08NoYes149
4R:R:H21 R:R:L191 19.90547.71YesNo074
5L:L:?1 R:R:E115 23.3566.92YesYes105
6R:R:E115 R:R:W111 21.32655.45YesYes159
7L:L:?1 R:R:Y22 38.05234.08YesYes109
8R:R:H21 R:R:L182 11.60535.14YesYes073
9R:R:P190 R:R:Y22 32.449111.13NoYes049
10R:R:P190 R:R:V25 31.47388.84NoYes046
11R:R:T187 R:R:V25 26.76223.17YesYes056
12L:L:?1 R:R:N95 31.328519.13YesYes106
13R:R:N95 R:R:Y92 33.29394.65YesYes166
14R:R:F46 R:R:Y92 19.24042.06NoYes076
15R:R:F46 R:R:Q281 11.51175.86NoNo074
16L:L:?1 R:R:M118 31.58719.85YesNo106
17R:R:M118 R:R:Y92 30.63158.38NoYes166
18R:R:C50 R:R:Y92 13.66932.69NoYes066
19R:R:C50 R:R:K93 11.73094.85NoNo066
20R:R:V288 R:R:Y92 23.2872.52NoYes076
21R:R:I53 R:R:V288 21.37333.07YesNo077
22L:L:?1 R:R:L122 70.05078.44YesNo006
23R:R:L122 R:R:W256 69.96955.69NoYes068
24R:R:N290 R:R:W256 10014.69NoYes098
25R:R:N290 R:R:N294 98.29575.45NoYes099
26L:L:?1 R:R:F260 71.02854.24YesYes106
27R:R:F260 R:R:W256 71.05816.01YesYes168
28R:R:L81 R:R:N294 17.80954.12NoYes299
29R:R:L81 R:R:S128 20.72317.51NoNo098
30R:R:N80 R:R:S128 19.37595.96YesNo098
31R:R:L129 R:R:N294 74.39788.24NoYes299
32R:R:L129 R:R:Y298 77.84358.21NoYes299
33R:R:I132 R:R:Y298 46.60364.84NoYes099
34R:R:I132 R:R:M74 28.19075.83NoYes098
35R:R:I78 R:R:M74 42.90922.92NoYes088
36R:R:I78 R:R:M305 38.14844.37NoYes488
37R:R:R136 R:R:Y298 29.03314.12NoYes099
38R:R:M74 R:R:R136 28.04794.96YesNo089
39R:R:E304 R:R:M305 21.74284.06YesYes478
40R:R:F77 R:R:I132 17.69373.77YesNo089
41R:R:F112 R:R:W111 22.486610.02YesYes169
42R:R:F112 R:R:P108 16.62232.89YesNo063
43R:R:P108 R:R:S107 14.79483.56NoNo037
44R:R:S107 R:R:V110 11.12513.23NoNo076
45L:L:?1 R:R:F119 12.68664.24YesYes105
46R:R:T126 R:R:W256 40.20744.85NoYes078
47R:R:I207 R:R:T126 39.39713.04YesNo077
48R:R:I207 R:R:L130 36.4445.71YesNo077
49R:R:L130 R:R:T210 35.20022.95NoNo076
50R:R:I207 R:R:I211 12.44772.94YesNo078
51R:R:I211 R:R:Y215 11.5933.63NoYes089
52R:R:L214 R:R:T210 33.95152.95NoNo066
53R:R:H137 R:R:L214 31.439316.71NoNo086
54R:R:H137 R:R:I218 25.06531.33NoNo088
55R:R:D266 R:R:T187 16.93274.34YesYes345
56R:R:D266 R:R:I188 13.07578.4YesNo044
57R:R:I218 R:R:V222 21.30931.54NoNo088
58R:R:S226 R:R:V222 10.87381.62NoNo058
59R:R:I188 R:R:L262 11.0292.85NoNo045
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y22 4.08 1 Yes Yes 0 9 0 1
L:L:?1 R:R:R31 10.58 1 Yes No 0 4 0 1
L:L:?1 R:R:N95 19.13 1 Yes Yes 0 6 0 1
L:L:?1 R:R:S99 15.69 1 Yes Yes 0 5 0 1
L:L:?1 R:R:T103 5.13 1 Yes No 0 5 0 1
L:L:?1 R:R:R114 6.35 1 Yes Yes 0 6 0 1
L:L:?1 R:R:E115 6.92 1 Yes Yes 0 5 0 1
L:L:?1 R:R:M118 9.85 1 Yes No 0 6 0 1
L:L:?1 R:R:F119 4.24 1 Yes Yes 0 5 0 1
L:L:?1 R:R:L122 8.44 1 Yes No 0 6 0 1
L:L:?1 R:R:L189 4.82 1 Yes No 0 5 0 1
L:L:?1 R:R:F260 4.24 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F263 3.18 1 Yes No 0 6 0 1
R:R:T103 R:R:Y22 8.74 1 No Yes 5 9 1 1
R:R:F104 R:R:Y22 5.16 1 Yes Yes 7 9 2 1
R:R:P190 R:R:Y22 11.13 0 No Yes 4 9 2 1
R:R:F104 R:R:R31 3.21 1 Yes No 7 4 2 1
R:R:N95 R:R:Y92 4.65 1 Yes Yes 6 6 1 2
R:R:M118 R:R:Y92 8.38 1 No Yes 6 6 1 2
R:R:N95 R:R:S99 5.96 1 Yes Yes 6 5 1 1
R:R:N95 R:R:R114 4.82 1 Yes Yes 6 6 1 1
R:R:M118 R:R:N95 5.61 1 No Yes 6 6 1 1
R:R:G100 R:R:S99 3.71 0 No Yes 6 5 2 1
R:R:R114 R:R:S99 6.59 1 Yes Yes 6 5 1 1
R:R:F104 R:R:T103 7.78 1 Yes No 7 5 2 1
R:R:R114 R:R:W111 8 1 Yes Yes 6 9 1 2
R:R:E115 R:R:W111 5.45 1 Yes Yes 5 9 1 2
R:R:E115 R:R:R114 3.49 1 Yes Yes 5 6 1 1
R:R:E115 R:R:L189 6.63 1 Yes No 5 5 1 1
R:R:E115 R:R:Y192 7.86 1 Yes Yes 5 3 1 2
R:R:F119 R:R:Y192 4.13 1 Yes Yes 5 3 1 2
R:R:F119 R:R:Y196 10.32 1 Yes Yes 5 6 1 2
R:R:L122 R:R:W256 5.69 0 No Yes 6 8 1 2
R:R:L189 R:R:Y192 8.21 1 No Yes 5 3 1 2
R:R:Y192 R:R:Y196 4.96 1 Yes Yes 3 6 2 2
R:R:F260 R:R:I201 5.02 1 Yes No 6 4 1 2
R:R:F204 R:R:W256 4.01 1 No Yes 7 8 2 2
R:R:F204 R:R:F260 38.58 1 No Yes 7 6 2 1
R:R:F260 R:R:W256 6.01 1 Yes Yes 6 8 1 2
R:R:F263 R:R:L259 4.87 1 No No 6 6 1 2
R:R:F260 R:R:F263 3.22 1 Yes No 6 6 1 1
R:R:C200 R:R:F119 2.79 0 No Yes 6 5 2 1
L:L:?1 R:R:I284 2.49 1 Yes No 0 5 0 1
R:R:A165 R:R:G123 1.95 0 No No 8 5 2 1
R:R:F119 R:R:G169 1.51 1 Yes No 5 7 1 2
L:L:?1 R:R:G123 1.49 1 Yes No 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7EW2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.89
Number of Linked Nodes 256
Number of Links 290
Number of Hubs 38
Number of Links mediated by Hubs 157
Number of Communities 7
Number of Nodes involved in Communities 53
Number of Links involved in Communities 76
Path Summary
Number Of Nodes in MetaPath 60
Number Of Links MetaPath 59
Number of Shortest Paths 79340
Length Of Smallest Path 3
Average Path Length 13.9713
Length of Longest Path 28
Minimum Path Strength 1.295
Average Path Strength 6.09265
Maximum Path Strength 22.945
Minimum Path Correlation 0.7
Average Path Correlation 0.928011
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 48.5412
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.6552
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • positive regulation of biological process   • positive regulation of cellular process   • metabolic process   • regulation of metabolic process   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • multicellular organismal process   • regulation of establishment of endothelial barrier   • cellular developmental process   • regulation of developmental process   • endothelium development   • negative regulation of biological process   • cell development   • regulation of cell differentiation   • negative regulation of endothelial cell development   • epithelial cell differentiation   • regulation of cell development   • regulation of epithelial cell differentiation   • endothelial cell development   • multicellular organism development   • cell differentiation   • regulation of endothelial cell development   • anatomical structure development   • negative regulation of cellular process   • regulation of multicellular organismal process   • negative regulation of cell differentiation   • developmental process   • epithelium development   • regulation of multicellular organismal development   • negative regulation of epithelial cell differentiation   • endothelial cell differentiation   • regulation of endothelial cell differentiation   • negative regulation of developmental process   • negative regulation of endothelial cell differentiation   • tissue development   • negative regulation of cell development   • epithelial cell development   • establishment of endothelial barrier   • negative regulation of establishment of endothelial barrier   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • defense response   • response to stress   • inflammatory response   • regulation of biosynthetic process   • regulation of interleukin-1 production   • interleukin-1 production   • regulation of macromolecule metabolic process   • gene expression   • regulation of interleukin-1 beta production   • macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • interleukin-1 beta production   • regulation of cytokine production   • cytokine production   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • cell surface receptor signaling pathway   • Notch signaling pathway   • anatomical structure morphogenesis   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • presynapse   • synapse   • cell junction   • intracellular anatomical structure   • cytoplasm   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeJ89
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeJ89
Name(2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol
Synonyms
Identifier
FormulaC19 H34 N O5 P
Molecular Weight387.451
SMILES
PubChem11452022
Formal Charge0
Total Atoms60
Total Chiral Atoms1
Total Bonds60
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ99500
Sequence
>7EW2_nogp_Chain_R
ETLREHYQY VGKLAGRST LTTVLFLVI CSFIVLENL MVLIAIWKN 
NKFHNRMYF FIGNLALCD LLAGIAYKV NILMSGKKT FSLSPTVWF 
LREGSMFVA LGASTCSLL AIAIERHLT MIKMRPYDA NKRHRVFLL 
IGMCWLIAF TLGALPILG WNCLHNLPD CSTILPLYS KKYIAFCIS 
IFTAILVTI VILYARIYF LVKSSSRKV ANHNNSERS MALLRTVVI 
VVSVFIACW SPLFILFLI DVACRVQAC PILFKAQWF IVLAVLNSA 
MNPVIYTLA SKEMRRAFF RL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EW2ALipidLysophospholipidS1P3Homo sapiensFingolimod-Gi1/β1/γ23.12021-09-29doi.org/10.1038/s41422-021-00567-w
7EW2 (No Gprot) ALipidLysophospholipidS1P3Homo sapiensFingolimod-3.12021-09-29doi.org/10.1038/s41422-021-00567-w
7EW3ALipidLysophospholipidS1P3Homo sapiensS1P-Gi1/β1/γ23.12021-09-29doi.org/10.1038/s41422-021-00567-w
7EW3 (No Gprot) ALipidLysophospholipidS1P3Homo sapiensS1P-3.12021-09-29doi.org/10.1038/s41422-021-00567-w
7EW4ALipidLysophospholipidS1P3Homo sapiensCYM5541-Gi1/β1/γ23.22021-09-29doi.org/10.1038/s41422-021-00567-w
7EW4 (No Gprot) ALipidLysophospholipidS1P3Homo sapiensCYM5541-3.22021-09-29doi.org/10.1038/s41422-021-00567-w
7C4SALipidLysophospholipidS1P3Homo sapiensS1P--3.22021-06-09doi.org/10.1126/sciadv.abf5325




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