psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y22	4.08	Yes	Yes	1	0	9
2	L:L:?1	R:R:R31	10.58	Yes	No	0	0	4
3	L:L:?1	R:R:N95	19.13	Yes	Yes	1	0	6
4	L:L:?1	R:R:S99	15.69	Yes	Yes	1	0	5
5	L:L:?1	R:R:T103	5.13	Yes	No	1	0	5
6	L:L:?1	R:R:R114	6.35	Yes	Yes	1	0	6
7	L:L:?1	R:R:E115	6.92	Yes	Yes	1	0	5
8	L:L:?1	R:R:M118	9.85	Yes	No	1	0	6
9	L:L:?1	R:R:F119	4.24	Yes	Yes	1	0	5
10	L:L:?1	R:R:L122	8.44	Yes	No	0	0	6
11	L:L:?1	R:R:L189	4.82	Yes	No	1	0	5
12	L:L:?1	R:R:F260	4.24	Yes	Yes	1	0	6
13	L:L:?1	R:R:F263	3.18	Yes	No	1	0	6
14	R:R:L179	R:R:T17	4.42	No	No	0	3	6
15	R:R:L18	R:R:R19	4.86	No	No	1	7	1
16	R:R:F104	R:R:L18	4.87	Yes	No	1	7	7
17	R:R:L28	R:R:R19	3.64	No	No	1	3	1
18	R:R:F104	R:R:R19	19.24	Yes	No	1	7	1
19	R:R:C178	R:R:H21	4.42	No	Yes	0	5	7
20	R:R:H21	R:R:L179	5.14	Yes	No	0	7	3
21	R:R:H21	R:R:L182	5.14	Yes	Yes	0	7	3
22	R:R:H21	R:R:L191	7.71	Yes	No	0	7	4
23	R:R:T103	R:R:Y22	8.74	No	Yes	1	5	9
24	R:R:F104	R:R:Y22	5.16	Yes	Yes	1	7	9
25	R:R:P190	R:R:Y22	11.13	No	Yes	0	4	9
26	R:R:L182	R:R:Y24	21.1	Yes	No	5	3	5
27	R:R:P183	R:R:Y24	8.34	No	No	5	4	5
28	R:R:V271	R:R:Y24	3.79	No	No	0	1	5
29	R:R:G26	R:R:V25	3.68	No	Yes	0	6	6
30	R:R:T187	R:R:V25	3.17	Yes	Yes	0	5	6
31	R:R:P190	R:R:V25	8.84	No	Yes	0	4	6
32	R:R:G26	R:R:Q272	3.29	No	No	0	6	1
33	R:R:F104	R:R:L28	3.65	Yes	No	1	7	3
34	R:R:F104	R:R:R31	3.21	Yes	No	0	7	4
35	R:R:L41	R:R:S39	3	No	No	0	4	3
36	R:R:S39	R:R:T42	3.2	No	No	0	3	5
37	R:R:I96	R:R:T43	3.04	No	No	0	6	6
38	R:R:F46	R:R:Q281	5.86	No	No	0	7	4
39	R:R:F46	R:R:V285	9.18	No	No	0	7	4
40	R:R:I49	R:R:V285	3.07	No	No	0	7	4
41	R:R:C50	R:R:K93	4.85	No	No	0	6	6
42	R:R:E56	R:R:F52	10.49	No	No	0	8	4
43	R:R:I53	R:R:V288	3.07	Yes	No	0	7	7
44	R:R:L58	R:R:V54	4.47	No	No	0	4	6
45	R:R:I90	R:R:V54	3.07	No	No	0	5	6
46	R:R:K93	R:R:V54	7.59	No	No	0	6	6
47	R:R:D85	R:R:N57	13.46	Yes	No	0	9	9
48	R:R:N57	R:R:P295	4.89	No	No	0	9	9
49	R:R:L58	R:R:L86	11.07	No	No	0	4	7
50	R:R:P295	R:R:V60	7.07	No	No	0	9	9
51	R:R:A82	R:R:L61	4.73	No	No	0	9	7
52	R:R:A63	R:R:F309	4.16	No	No	0	7	6
53	R:R:I64	R:R:I78	2.94	No	No	4	8	8
54	R:R:I64	R:R:M305	2.92	No	Yes	4	8	8
55	R:R:H71	R:R:K69	13.1	No	No	0	8	6
56	R:R:F70	R:R:Y75	8.25	No	No	0	8	9
57	R:R:F70	R:R:F76	6.43	No	Yes	0	8	4
58	R:R:M74	R:R:N72	4.21	Yes	No	0	8	7
59	R:R:R153	R:R:R73	11.73	Yes	No	0	5	5
60	R:R:R73	R:R:V154	5.23	No	No	0	5	7
61	R:R:I78	R:R:M74	2.92	No	Yes	0	8	8
62	R:R:I132	R:R:M74	5.83	No	Yes	0	9	8
63	R:R:E135	R:R:M74	8.12	Yes	Yes	0	9	8
64	R:R:M74	R:R:R136	4.96	Yes	No	0	8	9
65	R:R:E304	R:R:Y75	7.86	Yes	No	4	7	9
66	R:R:M305	R:R:Y75	4.79	Yes	No	4	8	9
67	R:R:F76	R:R:R151	3.21	Yes	No	0	4	2
68	R:R:F76	R:R:V154	5.24	Yes	No	0	4	7
69	R:R:F155	R:R:F76	7.5	No	Yes	0	1	4
70	R:R:F77	R:R:I132	3.77	Yes	No	0	8	9
71	R:R:E135	R:R:F77	10.49	Yes	Yes	0	9	8
72	R:R:F77	R:R:V154	9.18	Yes	No	0	8	7
73	R:R:F77	R:R:L157	6.09	Yes	No	0	8	6
74	R:R:I78	R:R:M305	4.37	No	Yes	4	8	8
75	R:R:C84	R:R:N80	4.72	No	Yes	6	8	9
76	R:R:N80	R:R:S128	5.96	Yes	No	0	9	8
77	R:R:I158	R:R:N80	5.66	No	Yes	0	7	9
78	R:R:C161	R:R:N80	4.72	No	Yes	0	7	9
79	R:R:N80	R:R:W162	4.52	Yes	Yes	6	9	9
80	R:R:L81	R:R:S128	7.51	No	No	0	9	8
81	R:R:L129	R:R:L81	5.54	No	No	2	9	9
82	R:R:L81	R:R:N294	4.12	No	Yes	2	9	9
83	R:R:L83	R:R:W162	4.56	No	Yes	0	6	9
84	R:R:A124	R:R:C84	3.61	No	No	0	8	8
85	R:R:C84	R:R:W162	3.92	No	Yes	6	8	9
86	R:R:D85	R:R:S125	4.42	Yes	No	0	9	9
87	R:R:D85	R:R:S291	10.31	Yes	No	0	9	9
88	R:R:L87	R:R:W162	3.42	No	Yes	0	7	9
89	R:R:A91	R:R:S117	3.42	No	No	0	5	4
90	R:R:N95	R:R:Y92	4.65	Yes	Yes	1	6	6
91	R:R:M118	R:R:Y92	8.38	No	Yes	1	6	6
92	R:R:N95	R:R:S99	5.96	Yes	Yes	1	6	5
93	R:R:N95	R:R:R114	4.82	Yes	Yes	1	6	6
94	R:R:M118	R:R:N95	5.61	No	Yes	1	6	6
95	R:R:G100	R:R:S99	3.71	No	Yes	0	6	5
96	R:R:R114	R:R:S99	6.59	Yes	Yes	1	6	5
97	R:R:F104	R:R:T103	7.78	Yes	No	1	7	5
98	R:R:L106	R:R:S105	3	No	No	0	6	3
99	R:R:L106	R:R:V110	4.47	No	No	0	6	6
100	R:R:P108	R:R:S107	3.56	No	No	0	3	7
101	R:R:S107	R:R:T109	4.8	No	No	0	7	1
102	R:R:S107	R:R:V110	3.23	No	No	0	7	6
103	R:R:F112	R:R:P108	2.89	Yes	No	0	6	3
104	R:R:F112	R:R:W111	10.02	Yes	Yes	1	6	9
105	R:R:R114	R:R:W111	8	Yes	Yes	1	6	9
106	R:R:E115	R:R:W111	5.45	Yes	Yes	1	5	9
107	R:R:L191	R:R:W111	17.08	No	Yes	1	4	9
108	R:R:F112	R:R:I173	6.28	Yes	No	0	6	5
109	R:R:F112	R:R:N177	4.83	Yes	No	0	6	5
110	R:R:F112	R:R:L191	4.87	Yes	No	1	6	4
111	R:R:E115	R:R:R114	3.49	Yes	Yes	1	5	6
112	R:R:E115	R:R:L189	6.63	Yes	No	1	5	5
113	R:R:E115	R:R:Y192	7.86	Yes	Yes	1	5	3
114	R:R:F119	R:R:Y192	4.13	Yes	Yes	1	5	3
115	R:R:F119	R:R:Y196	10.32	Yes	Yes	1	5	6
116	R:R:G169	R:R:V120	3.68	No	No	0	7	5
117	R:R:L122	R:R:W256	5.69	No	Yes	0	6	8
118	R:R:I207	R:R:T126	3.04	Yes	No	0	7	7
119	R:R:T126	R:R:W256	4.85	No	Yes	0	7	8
120	R:R:L129	R:R:N294	8.24	No	Yes	2	9	9
121	R:R:L129	R:R:Y298	8.21	No	Yes	2	9	9
122	R:R:I207	R:R:L130	5.71	Yes	No	0	7	7
123	R:R:L130	R:R:T210	2.95	No	No	0	7	6
124	R:R:I132	R:R:Y298	4.84	No	Yes	0	9	9
125	R:R:A133	R:R:Y215	4	No	Yes	0	8	9
126	R:R:I134	R:R:L214	4.28	No	No	0	7	6
127	R:R:E135	R:R:T139	5.64	Yes	No	0	9	8
128	R:R:E135	R:R:R153	4.65	Yes	Yes	0	9	5
129	R:R:R136	R:R:Y298	4.12	No	Yes	0	9	9
130	R:R:H137	R:R:L214	16.71	No	No	0	8	6
131	R:R:H137	R:R:R217	10.16	No	No	0	8	6
132	R:R:L138	R:R:R153	6.07	No	Yes	0	5	5
133	R:R:I218	R:R:M140	5.83	No	No	0	8	9
134	R:R:K142	R:R:R144	4.95	No	No	0	5	6
135	R:R:P145	R:R:Y146	4.17	No	No	0	5	7
136	R:R:L157	R:R:R153	3.64	No	Yes	0	6	5
137	R:R:I164	R:R:M160	2.92	No	No	0	3	3
138	R:R:L163	R:R:T167	2.95	No	No	0	3	3
139	R:R:L171	R:R:P172	3.28	No	No	1	6	5
140	R:R:L171	R:R:W176	5.69	No	No	1	6	4
141	R:R:L171	R:R:Y196	8.21	No	Yes	1	6	6
142	R:R:P172	R:R:Y192	8.34	No	Yes	1	5	3
143	R:R:P172	R:R:Y196	13.91	No	Yes	1	5	6
144	R:R:K195	R:R:W176	33.65	No	No	0	4	4
145	R:R:W176	R:R:Y196	5.79	No	Yes	1	4	6
146	R:R:C178	R:R:C185	7.28	No	No	0	5	9
147	R:R:N181	R:R:P183	3.26	No	No	0	3	4
148	R:R:D184	R:R:N181	10.77	No	No	0	3	3
149	R:R:L182	R:R:P183	3.28	Yes	No	5	3	4
150	R:R:I197	R:R:S186	3.1	No	No	0	6	5
151	R:R:D266	R:R:S186	4.42	Yes	No	0	4	5
152	R:R:D266	R:R:T187	4.34	Yes	Yes	3	4	5
153	R:R:T187	R:R:V271	3.17	Yes	No	0	5	1
154	R:R:L277	R:R:T187	5.9	No	Yes	3	2	5
155	R:R:D266	R:R:I188	8.4	Yes	No	0	4	4
156	R:R:A280	R:R:I188	3.25	No	No	0	4	4
157	R:R:L189	R:R:Y192	8.21	No	Yes	1	5	3
158	R:R:Y192	R:R:Y196	4.96	Yes	Yes	1	3	6
159	R:R:K195	R:R:S193	12.24	No	No	0	4	5
160	R:R:I197	R:R:V267	3.07	No	No	0	6	4
161	R:R:F199	R:R:I203	8.79	No	No	0	4	5
162	R:R:F260	R:R:I201	5.02	Yes	No	0	6	4
163	R:R:I203	R:R:I207	2.94	No	Yes	0	5	7
164	R:R:F204	R:R:W256	4.01	No	Yes	1	7	8
165	R:R:F204	R:R:F260	38.58	No	Yes	1	7	6
166	R:R:I207	R:R:I211	2.94	Yes	No	0	7	8
167	R:R:F252	R:R:L208	4.87	No	No	0	9	6
168	R:R:L214	R:R:T210	2.95	No	No	0	6	6
169	R:R:I211	R:R:Y215	3.63	No	Yes	0	8	9
170	R:R:Y215	R:R:Y298	4.96	Yes	Yes	2	9	9
171	R:R:F220	R:R:Y219	4.13	No	Yes	0	1	6
172	R:R:K223	R:R:Y219	3.58	No	Yes	7	5	6
173	R:R:S238	R:R:Y219	5.09	No	Yes	7	7	6
174	R:R:L242	R:R:Y219	17.58	No	Yes	0	7	6
175	R:R:L241	R:R:V222	4.47	No	No	0	8	8
176	R:R:K223	R:R:S238	3.06	No	No	7	5	7
177	R:R:N234	R:R:S226	8.94	Yes	No	0	4	5
178	R:R:N231	R:R:N234	4.09	No	Yes	0	5	4
179	R:R:N234	R:R:R237	8.44	Yes	No	0	4	4
180	R:R:E236	R:R:R237	5.82	No	No	0	4	4
181	R:R:L242	R:R:V246	2.98	No	No	0	7	6
182	R:R:I253	R:R:V249	3.07	No	No	0	6	8
183	R:R:M293	R:R:V251	4.56	No	No	0	7	6
184	R:R:I297	R:R:V251	4.61	No	No	0	8	6
185	R:R:F252	R:R:W256	5.01	No	Yes	0	9	8
186	R:R:C255	R:R:N290	7.87	No	No	0	9	9
187	R:R:F260	R:R:W256	6.01	Yes	Yes	1	6	8
188	R:R:A287	R:R:W256	3.89	No	Yes	0	7	8
189	R:R:N290	R:R:W256	14.69	No	Yes	0	9	8
190	R:R:P258	R:R:S257	3.56	No	No	0	9	5
191	R:R:F283	R:R:P258	2.89	No	No	0	6	9
192	R:R:L286	R:R:P258	4.93	No	No	0	7	9
193	R:R:F263	R:R:L259	4.87	No	No	0	6	6
194	R:R:F260	R:R:F263	3.22	Yes	No	1	6	6
195	R:R:F283	R:R:L262	7.31	No	No	0	6	5
196	R:R:D266	R:R:L277	13.57	Yes	No	3	4	2
197	R:R:C269	R:R:C274	7.28	No	Yes	3	4	2
198	R:R:C274	R:R:L277	3.17	Yes	No	3	2	2
199	R:R:K279	R:R:W282	5.8	No	No	0	4	4
200	R:R:N290	R:R:N294	5.45	No	Yes	0	9	9
201	R:R:I297	R:R:Y298	3.63	No	Yes	0	8	9
202	R:R:L300	R:R:T299	2.95	No	No	0	5	7
203	R:R:M305	R:R:T299	3.01	Yes	No	0	8	7
204	R:R:M305	R:R:S302	3.07	Yes	No	0	8	8
205	R:R:E304	R:R:M305	4.06	Yes	Yes	4	7	8
206	R:R:R306	R:R:R307	7.46	No	No	0	8	4
207	R:R:F310	R:R:R306	4.28	No	No	0	4	8
208	R:R:I49	R:R:L45	2.85	No	No	0	7	4
209	R:R:I188	R:R:L262	2.85	No	No	0	4	5
210	R:R:I253	R:R:L208	2.85	No	No	0	6	6
211	R:R:I261	R:R:L264	2.85	No	No	0	4	5
212	R:R:K102	R:R:L106	2.82	No	No	0	3	6
213	R:R:K69	R:R:N67	2.8	No	No	0	6	7
214	R:R:C200	R:R:F119	2.79	No	Yes	0	6	5
215	R:R:L61	R:R:L83	2.77	No	No	0	7	6
216	R:R:A131	R:R:F77	2.77	No	Yes	0	7	8
217	R:R:L286	R:R:L289	2.77	No	No	0	7	5
218	R:R:E56	R:R:I53	2.73	No	Yes	0	8	7
219	R:R:C50	R:R:Y92	2.69	No	Yes	0	6	6
220	R:R:D85	R:R:N294	2.69	Yes	Yes	0	9	9
221	R:R:L28	R:R:Q23	2.66	No	No	0	3	7
222	R:R:V288	R:R:Y92	2.52	No	Yes	0	7	6
223	R:R:V248	R:R:Y215	2.52	No	Yes	2	8	9
224	R:R:V248	R:R:Y298	2.52	No	Yes	2	8	9
225	L:L:?1	R:R:I284	2.49	Yes	No	0	0	5
226	R:R:F278	R:R:K27	2.48	No	No	0	1	7
227	R:R:F199	R:R:L168	2.44	No	No	0	4	5
228	R:R:T42	R:R:W282	2.43	No	No	0	5	4
229	R:R:L312	R:R:R311	2.43	No	No	0	6	4
230	R:R:I96	R:R:Y92	2.42	No	Yes	0	6	6
231	R:R:Q281	R:R:W282	2.19	No	No	0	4	4
232	R:R:F46	R:R:Y92	2.06	No	Yes	0	7	6
233	R:R:F166	R:R:W162	2	No	Yes	0	4	9
234	R:R:A82	R:R:G79	1.95	No	No	0	9	6
235	R:R:A88	R:R:G89	1.95	No	No	0	8	7
236	R:R:A165	R:R:G123	1.95	No	No	0	8	5
237	R:R:C274	R:R:P275	1.88	Yes	No	0	2	2
238	R:R:C127	R:R:C161	1.82	No	No	0	5	7
239	R:R:A273	R:R:C269	1.81	No	No	3	3	4
240	R:R:A273	R:R:C274	1.81	No	Yes	3	3	2
241	R:R:A121	R:R:A88	1.79	No	No	0	7	8
242	R:R:A121	R:R:A91	1.79	No	No	0	7	5
243	R:R:G89	R:R:I53	1.76	No	Yes	0	7	7
244	R:R:G159	R:R:I158	1.76	No	No	0	3	7
245	R:R:C274	R:R:I276	1.64	Yes	No	0	2	4
246	R:R:A292	R:R:I53	1.62	No	Yes	0	6	7
247	R:R:S226	R:R:V222	1.62	No	No	0	5	8
248	R:R:A268	R:R:I265	1.62	No	No	0	4	4
249	R:R:V44	R:R:V48	1.6	No	No	0	5	4
250	R:R:V212	R:R:V249	1.6	No	No	0	4	8
251	R:R:V245	R:R:V249	1.6	No	No	0	8	8
252	R:R:T205	R:R:V209	1.59	No	No	0	3	2
253	R:R:T244	R:R:V248	1.59	No	No	0	9	8
254	R:R:T40	R:R:T43	1.57	No	No	0	3	6
255	R:R:A308	R:R:N67	1.56	No	No	0	6	7
256	R:R:I261	R:R:S257	1.55	No	No	0	4	5
257	R:R:I213	R:R:V209	1.54	No	No	0	4	2
258	R:R:I218	R:R:V222	1.54	No	No	0	8	8
259	R:R:I247	R:R:V251	1.54	No	No	0	7	6
260	R:R:K27	R:R:V25	1.52	No	Yes	0	7	6
261	R:R:M98	R:R:V94	1.52	No	No	0	4	7
262	R:R:F119	R:R:G169	1.51	Yes	No	0	5	7
263	R:R:A308	R:R:E304	1.51	No	Yes	0	6	7
264	L:L:?1	R:R:G123	1.49	Yes	No	0	0	5
265	R:R:N234	R:R:V229	1.48	Yes	No	0	4	7
266	R:R:K102	R:R:M98	1.44	No	No	0	3	4
267	R:R:K142	R:R:K150	1.44	No	No	0	5	7
268	R:R:P145	R:R:R144	1.44	No	No	0	5	6
269	R:R:I96	R:R:L97	1.43	No	No	0	6	5
270	R:R:I164	R:R:L163	1.43	No	No	0	3	3
271	R:R:I173	R:R:L174	1.43	No	No	0	5	4
272	R:R:I265	R:R:L262	1.43	No	No	0	4	5
273	R:R:I265	R:R:L264	1.43	No	No	0	4	5
274	R:R:K93	R:R:L47	1.41	No	No	0	6	5
275	R:R:L55	R:R:M59	1.41	No	No	0	4	7
276	R:R:K66	R:R:L312	1.41	No	No	0	5	6
277	R:R:L221	R:R:M140	1.41	No	No	0	5	9
278	R:R:A273	R:R:R270	1.38	No	No	0	3	1
279	R:R:E304	R:R:K303	1.35	Yes	No	0	7	5
280	R:R:E20	R:R:L182	1.33	No	Yes	0	2	3
281	R:R:E56	R:R:L55	1.33	No	No	0	8	4
282	R:R:H137	R:R:I218	1.33	No	No	0	8	8
283	R:R:E236	R:R:N233	1.31	No	No	0	4	4
284	R:R:H232	R:R:N233	1.28	No	No	0	3	4
285	R:R:I213	R:R:R217	1.25	No	No	0	4	6
286	R:R:K194	R:R:R270	1.24	No	No	0	3	1
287	R:R:K303	R:R:R307	1.24	No	No	0	5	4
288	R:R:F309	R:R:L300	1.22	No	No	0	6	5
289	R:R:I62	R:R:W65	1.17	No	No	0	4	3
290	R:R:L241	R:R:Y219	1.17	No	Yes	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.10867	15	1	0
2	R:R:H21	5.6025	4	0	7
3	R:R:Y22	7.2775	4	1	9
4	R:R:V25	4.3025	4	0	6
5	R:R:I53	2.295	4	0	7
6	R:R:M74	5.208	5	0	8
7	R:R:F76	5.595	4	0	4
8	R:R:F77	6.46	5	0	8
9	R:R:N80	5.116	5	6	9
10	R:R:D85	7.72	4	0	9
11	R:R:Y92	3.78667	6	1	6
12	R:R:N95	8.034	5	1	6
13	R:R:S99	7.9875	4	1	5
14	R:R:F104	7.31833	6	1	7
15	R:R:W111	10.1375	4	1	9
16	R:R:F112	5.778	5	1	6
17	R:R:R114	5.85	5	1	6
18	R:R:E115	6.07	5	1	5
19	R:R:F119	4.598	5	1	5
20	R:R:E135	7.225	4	0	9
21	R:R:R153	6.5225	4	0	5
22	R:R:W162	3.684	5	6	9
23	R:R:L182	7.7125	4	5	3
24	R:R:T187	4.145	4	3	5
25	R:R:Y192	6.7	5	1	3
26	R:R:Y196	8.638	5	1	6
27	R:R:I207	3.6575	4	0	7
28	R:R:Y215	3.7775	4	2	9
29	R:R:Y219	6.31	5	7	6
30	R:R:N234	5.7375	4	0	4
31	R:R:W256	6.30714	7	1	8
32	R:R:F260	11.414	5	1	6
33	R:R:D266	7.6825	4	3	4
34	R:R:C274	3.156	5	3	2
35	R:R:N294	5.125	4	2	9
36	R:R:Y298	4.71333	6	2	9
37	R:R:E304	3.695	4	4	7
38	R:R:M305	3.70333	6	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R114	21.3191	6.35	Yes	Yes	1	0	6
2	R:R:R114	R:R:W111	23.0186	8	Yes	Yes	1	6	9
3	R:R:L191	R:R:W111	20.2133	17.08	No	Yes	1	4	9
4	R:R:H21	R:R:L191	19.9054	7.71	Yes	No	0	7	4
5	L:L:?1	R:R:E115	23.356	6.92	Yes	Yes	1	0	5
6	R:R:E115	R:R:W111	21.3265	5.45	Yes	Yes	1	5	9
7	L:L:?1	R:R:Y22	38.0523	4.08	Yes	Yes	1	0	9
8	R:R:H21	R:R:L182	11.6053	5.14	Yes	Yes	0	7	3
9	R:R:P190	R:R:Y22	32.4491	11.13	No	Yes	0	4	9
10	R:R:P190	R:R:V25	31.4738	8.84	No	Yes	0	4	6
11	R:R:T187	R:R:V25	26.7622	3.17	Yes	Yes	0	5	6
12	L:L:?1	R:R:N95	31.3285	19.13	Yes	Yes	1	0	6
13	R:R:N95	R:R:Y92	33.2939	4.65	Yes	Yes	1	6	6
14	R:R:F46	R:R:Y92	19.2404	2.06	No	Yes	0	7	6
15	R:R:F46	R:R:Q281	11.5117	5.86	No	No	0	7	4
16	L:L:?1	R:R:M118	31.5871	9.85	Yes	No	1	0	6
17	R:R:M118	R:R:Y92	30.6315	8.38	No	Yes	1	6	6
18	R:R:C50	R:R:Y92	13.6693	2.69	No	Yes	0	6	6
19	R:R:C50	R:R:K93	11.7309	4.85	No	No	0	6	6
20	R:R:V288	R:R:Y92	23.287	2.52	No	Yes	0	7	6
21	R:R:I53	R:R:V288	21.3733	3.07	Yes	No	0	7	7
22	L:L:?1	R:R:L122	70.0507	8.44	Yes	No	0	0	6
23	R:R:L122	R:R:W256	69.9695	5.69	No	Yes	0	6	8
24	R:R:N290	R:R:W256	100	14.69	No	Yes	0	9	8
25	R:R:N290	R:R:N294	98.2957	5.45	No	Yes	0	9	9
26	L:L:?1	R:R:F260	71.0285	4.24	Yes	Yes	1	0	6
27	R:R:F260	R:R:W256	71.0581	6.01	Yes	Yes	1	6	8
28	R:R:L81	R:R:N294	17.8095	4.12	No	Yes	2	9	9
29	R:R:L81	R:R:S128	20.7231	7.51	No	No	0	9	8
30	R:R:N80	R:R:S128	19.3759	5.96	Yes	No	0	9	8
31	R:R:L129	R:R:N294	74.3978	8.24	No	Yes	2	9	9
32	R:R:L129	R:R:Y298	77.8435	8.21	No	Yes	2	9	9
33	R:R:I132	R:R:Y298	46.6036	4.84	No	Yes	0	9	9
34	R:R:I132	R:R:M74	28.1907	5.83	No	Yes	0	9	8
35	R:R:I78	R:R:M74	42.9092	2.92	No	Yes	0	8	8
36	R:R:I78	R:R:M305	38.1484	4.37	No	Yes	4	8	8
37	R:R:R136	R:R:Y298	29.0331	4.12	No	Yes	0	9	9
38	R:R:M74	R:R:R136	28.0479	4.96	Yes	No	0	8	9
39	R:R:E304	R:R:M305	21.7428	4.06	Yes	Yes	4	7	8
40	R:R:F77	R:R:I132	17.6937	3.77	Yes	No	0	8	9
41	R:R:F112	R:R:W111	22.4866	10.02	Yes	Yes	1	6	9
42	R:R:F112	R:R:P108	16.6223	2.89	Yes	No	0	6	3
43	R:R:P108	R:R:S107	14.7948	3.56	No	No	0	3	7
44	R:R:S107	R:R:V110	11.1251	3.23	No	No	0	7	6
45	L:L:?1	R:R:F119	12.6866	4.24	Yes	Yes	1	0	5
46	R:R:T126	R:R:W256	40.2074	4.85	No	Yes	0	7	8
47	R:R:I207	R:R:T126	39.3971	3.04	Yes	No	0	7	7
48	R:R:I207	R:R:L130	36.444	5.71	Yes	No	0	7	7
49	R:R:L130	R:R:T210	35.2002	2.95	No	No	0	7	6
50	R:R:I207	R:R:I211	12.4477	2.94	Yes	No	0	7	8
51	R:R:I211	R:R:Y215	11.593	3.63	No	Yes	0	8	9
52	R:R:L214	R:R:T210	33.9515	2.95	No	No	0	6	6
53	R:R:H137	R:R:L214	31.4393	16.71	No	No	0	8	6
54	R:R:H137	R:R:I218	25.0653	1.33	No	No	0	8	8
55	R:R:D266	R:R:T187	16.9327	4.34	Yes	Yes	3	4	5
56	R:R:D266	R:R:I188	13.0757	8.4	Yes	No	0	4	4
57	R:R:I218	R:R:V222	21.3093	1.54	No	No	0	8	8
58	R:R:S226	R:R:V222	10.8738	1.62	No	No	0	5	8
59	R:R:I188	R:R:L262	11.029	2.85	No	No	0	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y22	4.08	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:R31	10.58	1	Yes	No	0	4	0	1
L:L:?1	R:R:N95	19.13	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S99	15.69	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:T103	5.13	1	Yes	No	0	5	0	1
L:L:?1	R:R:R114	6.35	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:E115	6.92	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M118	9.85	1	Yes	No	0	6	0	1
L:L:?1	R:R:F119	4.24	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L122	8.44	1	Yes	No	0	6	0	1
L:L:?1	R:R:L189	4.82	1	Yes	No	0	5	0	1
L:L:?1	R:R:F260	4.24	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F263	3.18	1	Yes	No	0	6	0	1
R:R:T103	R:R:Y22	8.74	1	No	Yes	5	9	1	1
R:R:F104	R:R:Y22	5.16	1	Yes	Yes	7	9	2	1
R:R:P190	R:R:Y22	11.13	0	No	Yes	4	9	2	1
R:R:F104	R:R:R31	3.21	1	Yes	No	7	4	2	1
R:R:N95	R:R:Y92	4.65	1	Yes	Yes	6	6	1	2
R:R:M118	R:R:Y92	8.38	1	No	Yes	6	6	1	2
R:R:N95	R:R:S99	5.96	1	Yes	Yes	6	5	1	1
R:R:N95	R:R:R114	4.82	1	Yes	Yes	6	6	1	1
R:R:M118	R:R:N95	5.61	1	No	Yes	6	6	1	1
R:R:G100	R:R:S99	3.71	0	No	Yes	6	5	2	1
R:R:R114	R:R:S99	6.59	1	Yes	Yes	6	5	1	1
R:R:F104	R:R:T103	7.78	1	Yes	No	7	5	2	1
R:R:R114	R:R:W111	8	1	Yes	Yes	6	9	1	2
R:R:E115	R:R:W111	5.45	1	Yes	Yes	5	9	1	2
R:R:E115	R:R:R114	3.49	1	Yes	Yes	5	6	1	1
R:R:E115	R:R:L189	6.63	1	Yes	No	5	5	1	1
R:R:E115	R:R:Y192	7.86	1	Yes	Yes	5	3	1	2
R:R:F119	R:R:Y192	4.13	1	Yes	Yes	5	3	1	2
R:R:F119	R:R:Y196	10.32	1	Yes	Yes	5	6	1	2
R:R:L122	R:R:W256	5.69	0	No	Yes	6	8	1	2
R:R:L189	R:R:Y192	8.21	1	No	Yes	5	3	1	2
R:R:Y192	R:R:Y196	4.96	1	Yes	Yes	3	6	2	2
R:R:F260	R:R:I201	5.02	1	Yes	No	6	4	1	2
R:R:F204	R:R:W256	4.01	1	No	Yes	7	8	2	2
R:R:F204	R:R:F260	38.58	1	No	Yes	7	6	2	1
R:R:F260	R:R:W256	6.01	1	Yes	Yes	6	8	1	2
R:R:F263	R:R:L259	4.87	1	No	No	6	6	1	2
R:R:F260	R:R:F263	3.22	1	Yes	No	6	6	1	1
R:R:C200	R:R:F119	2.79	0	No	Yes	6	5	2	1
L:L:?1	R:R:I284	2.49	1	Yes	No	0	5	0	1
R:R:A165	R:R:G123	1.95	0	No	No	8	5	2	1
R:R:F119	R:R:G169	1.51	1	Yes	No	5	7	1	2
L:L:?1	R:R:G123	1.49	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EW2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.89
Number of Linked Nodes	256
Number of Links	290
Number of Hubs	38
Number of Links mediated by Hubs	157
Number of Communities	7
Number of Nodes involved in Communities	53
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	79340
Length Of Smallest Path	3
Average Path Length	13.9713
Length of Longest Path	28
Minimum Path Strength	1.295
Average Path Strength	6.09265
Maximum Path Strength	22.945
Minimum Path Correlation	0.7
Average Path Correlation	0.928011
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	48.5415
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.6552
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cell adhesion molecule binding • integrin binding • signaling receptor binding • lipid binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • bioactive lipid receptor activity • sphingosine-1-phosphate receptor activity • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • metabolic process • regulation of metabolic process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • regulation of establishment of endothelial barrier • cellular developmental process • regulation of developmental process • endothelium development • negative regulation of biological process • cell development • regulation of cell differentiation • negative regulation of endothelial cell development • epithelial cell differentiation • regulation of cell development • regulation of epithelial cell differentiation • endothelial cell development • cell differentiation • regulation of endothelial cell development • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of cell differentiation • epithelium development • regulation of multicellular organismal development • negative regulation of epithelial cell differentiation • endothelial cell differentiation • regulation of endothelial cell differentiation • negative regulation of developmental process • negative regulation of endothelial cell differentiation • tissue development • negative regulation of cell development • epithelial cell development • establishment of endothelial barrier • negative regulation of establishment of endothelial barrier • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • defense response • response to stress • inflammatory response • regulation of biosynthetic process • regulation of interleukin-1 production • interleukin-1 production • regulation of macromolecule metabolic process • gene expression • regulation of interleukin-1 beta production • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • interleukin-1 beta production • regulation of cytokine production • cytokine production • regulation of macromolecule biosynthetic process • macromolecule metabolic process • cell surface receptor signaling pathway • Notch signaling pathway • anatomical structure morphogenesis • presynapse
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J89
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	J89
Name	(2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol
Synonyms
Identifier
Formula	C19 H34 N O5 P
Molecular Weight	387.451
SMILES
PubChem	11452022
Formal Charge	0
Total Atoms	60
Total Chiral Atoms	1
Total Bonds	60
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99500
Sequence	>7EW2_nogp_Chain_R E T L R E H Y Q Y V G K L A G R S T L T T V L F L V I C S F I V L E N L M V L I A I W K N N K F H N R M Y F F I G N L A L C D L L A G I A Y K V N I L M S G K K T F S L S P T V W F L R E G S M F V A L G A S T C S L L A I A I E R H L T M I K M R P Y D A N K R H R V F L L I G M C W L I A F T L G A L P I L G W N C L H N L P D C S T I L P L Y S K K Y I A F C I S I F T A I L V T I V I L Y A R I Y F L V K S S S R K V A N H N N S E R S M A L L R T V V I V V S V F I A C W S P L F I L F L I D V A C R V Q A C P I L F K A Q W F I V L A V L N S A M N P V I Y T L A S K E M R R A F F R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7EW4	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	CYM5541	-	Gi1/β1/γ2	3.2	2021-09-29	10.1038/s41422-021-00567-w
	7EW4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	CYM5541	-		3.2	2021-09-29	10.1038/s41422-021-00567-w
	7EW3	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	Gi1/β1/γ2	3.1	2021-09-29	10.1038/s41422-021-00567-w
	7EW3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-		3.1	2021-09-29	10.1038/s41422-021-00567-w
	7EW2	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	Fingolimod	-	Gi1/β1/γ2	3.1	2021-09-29	10.1038/s41422-021-00567-w
	7EW2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	Fingolimod	-		3.1	2021-09-29	10.1038/s41422-021-00567-w
	7C4S	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	-	3.2	2021-06-09	10.1126/sciadv.abf5325

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