psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L18	R:R:Y22	3.52	No	Yes	1	7	9
2	R:R:F104	R:R:L18	3.65	No	No	1	7	7
3	R:R:L18	R:R:W111	3.42	No	Yes	1	7	9
4	R:R:E20	R:R:L182	3.98	No	Yes	0	2	3
5	R:R:H21	R:R:L182	3.86	Yes	Yes	1	7	3
6	R:R:C185	R:R:H21	2.95	No	Yes	1	9	7
7	R:R:H21	R:R:L191	11.57	Yes	No	1	7	4
8	R:R:K27	R:R:Y22	8.36	No	Yes	0	7	9
9	R:R:F104	R:R:Y22	5.16	No	Yes	1	7	9
10	R:R:P190	R:R:Y22	9.74	No	Yes	0	4	9
11	R:R:L28	R:R:Q23	14.64	No	No	0	3	7
12	R:R:L182	R:R:Y24	10.55	Yes	No	0	3	5
13	R:R:V271	R:R:Y24	5.05	No	No	0	1	5
14	R:R:T187	R:R:V25	3.17	No	No	0	5	6
15	R:R:P190	R:R:V25	3.53	No	No	0	4	6
16	R:R:G26	R:R:Q272	4.93	No	No	0	6	1
17	R:R:L41	R:R:S39	3	No	No	0	4	3
18	R:R:S39	R:R:T42	3.2	No	No	0	3	5
19	R:R:F46	R:R:Q281	4.68	Yes	No	0	7	4
20	R:R:F46	R:R:V285	6.55	Yes	No	0	7	4
21	R:R:K93	R:R:L47	4.23	No	No	0	6	5
22	R:R:C50	R:R:Y92	4.03	No	Yes	0	6	6
23	R:R:C50	R:R:K93	3.23	No	No	0	6	6
24	R:R:I53	R:R:N57	4.25	Yes	Yes	4	7	9
25	R:R:I53	R:R:V288	3.07	Yes	No	0	7	7
26	R:R:I53	R:R:S291	3.1	Yes	No	4	7	9
27	R:R:I90	R:R:V54	4.61	No	No	0	5	6
28	R:R:E56	R:R:P295	11	No	No	0	8	9
29	R:R:D85	R:R:N57	5.39	Yes	Yes	4	9	9
30	R:R:L86	R:R:N57	6.87	No	Yes	0	7	9
31	R:R:N57	R:R:S291	4.47	Yes	No	4	9	9
32	R:R:I64	R:R:V60	3.07	No	No	0	8	9
33	R:R:A82	R:R:V60	3.39	No	No	0	9	9
34	R:R:P295	R:R:V60	3.53	No	No	0	9	9
35	R:R:L61	R:R:W65	3.42	No	No	0	7	3
36	R:R:A82	R:R:L61	3.15	No	No	0	9	7
37	R:R:A63	R:R:L312	3.15	No	No	0	7	6
38	R:R:I64	R:R:I78	2.94	No	No	0	8	8
39	R:R:G79	R:R:I64	3.53	No	No	0	6	8
40	R:R:K66	R:R:L312	12.69	No	No	0	5	6
41	R:R:K69	R:R:N67	8.39	No	No	5	6	7
42	R:R:N67	R:R:Y75	11.63	No	Yes	5	7	9
43	R:R:K69	R:R:Y75	4.78	No	Yes	5	6	9
44	R:R:E304	R:R:K69	4.05	No	No	5	7	6
45	R:R:F70	R:R:F76	5.36	No	Yes	0	8	4
46	R:R:M74	R:R:N72	4.21	No	No	0	8	7
47	R:R:E135	R:R:R73	12.79	Yes	Yes	7	9	5
48	R:R:R73	R:R:T139	3.88	Yes	No	7	5	8
49	R:R:R153	R:R:R73	10.66	No	Yes	0	5	5
50	R:R:R73	R:R:V154	6.54	Yes	Yes	0	5	7
51	R:R:E135	R:R:M74	4.06	Yes	No	0	9	8
52	R:R:M74	R:R:R136	4.96	No	Yes	0	8	9
53	R:R:E304	R:R:Y75	7.86	No	Yes	5	7	9
54	R:R:M305	R:R:Y75	8.38	No	Yes	0	8	9
55	R:R:F76	R:R:R151	7.48	Yes	No	6	4	2
56	R:R:F76	R:R:V154	3.93	Yes	Yes	0	4	7
57	R:R:F77	R:R:I132	5.02	Yes	No	0	8	9
58	R:R:E135	R:R:F77	9.33	Yes	Yes	0	9	8
59	R:R:F77	R:R:V154	9.18	Yes	Yes	0	8	7
60	R:R:F77	R:R:L157	4.87	Yes	No	0	8	6
61	R:R:I78	R:R:Y298	3.63	No	Yes	0	8	9
62	R:R:N80	R:R:W162	10.17	No	Yes	0	9	9
63	R:R:D85	R:R:L81	9.5	Yes	No	0	9	9
64	R:R:L81	R:R:S128	6.01	No	No	0	9	8
65	R:R:L81	R:R:N294	4.12	No	Yes	0	9	9
66	R:R:L83	R:R:L87	5.54	No	No	0	6	7
67	R:R:D85	R:R:S125	5.89	Yes	No	0	9	9
68	R:R:D85	R:R:S291	7.36	Yes	No	4	9	9
69	R:R:M118	R:R:Y92	9.58	Yes	Yes	0	6	6
70	R:R:I284	R:R:Y92	6.04	No	Yes	0	5	6
71	R:R:V288	R:R:Y92	3.79	No	Yes	0	7	6
72	R:R:N95	R:R:R114	6.03	No	Yes	0	6	6
73	R:R:M118	R:R:N95	8.41	Yes	No	0	6	6
74	R:R:L106	R:R:M98	4.24	No	Yes	1	6	4
75	R:R:M98	R:R:R114	4.96	Yes	Yes	1	4	6
76	R:R:F104	R:R:T103	9.08	No	No	0	7	5
77	R:R:L106	R:R:V110	7.45	No	No	0	6	6
78	R:R:L106	R:R:R114	6.07	No	Yes	1	6	6
79	R:R:P108	R:R:S107	3.56	No	No	0	3	7
80	R:R:S107	R:R:T109	3.2	No	No	0	7	1
81	R:R:S107	R:R:V110	3.23	No	No	0	7	6
82	R:R:F112	R:R:W111	4.01	Yes	Yes	1	6	9
83	R:R:R114	R:R:W111	7	Yes	Yes	1	6	9
84	R:R:E115	R:R:W111	16.36	Yes	Yes	1	5	9
85	R:R:L191	R:R:W111	11.39	No	Yes	1	4	9
86	R:R:F112	R:R:I173	5.02	Yes	No	0	6	5
87	R:R:F112	R:R:N177	9.67	Yes	No	0	6	5
88	R:R:F112	R:R:L191	9.74	Yes	No	1	6	4
89	R:R:E115	R:R:R114	4.65	Yes	Yes	1	5	6
90	R:R:E115	R:R:L189	5.3	Yes	No	1	5	5
91	R:R:E115	R:R:Y192	4.49	Yes	No	1	5	3
92	L:L:?1	R:R:M118	4.27	Yes	Yes	0	0	6
93	R:R:F119	R:R:Y196	9.28	Yes	Yes	2	5	6
94	R:R:C200	R:R:F119	4.19	Yes	Yes	2	6	5
95	L:L:?1	R:R:F119	10.1	Yes	Yes	2	0	5
96	L:L:?1	R:R:L122	11.48	Yes	No	0	0	6
97	L:L:?1	R:R:G123	3.87	Yes	No	0	0	5
98	R:R:A124	R:R:W162	3.89	No	Yes	0	8	9
99	R:R:T126	R:R:W256	4.85	No	Yes	2	7	8
100	L:L:?1	R:R:T126	3.34	Yes	No	2	0	7
101	R:R:L129	R:R:N294	6.87	No	Yes	3	9	9
102	R:R:L129	R:R:Y298	8.21	No	Yes	3	9	9
103	R:R:I207	R:R:L130	8.56	No	Yes	8	7	7
104	R:R:L130	R:R:T210	2.95	Yes	No	0	7	6
105	R:R:I211	R:R:L130	4.28	No	Yes	8	8	7
106	R:R:I132	R:R:R136	6.26	No	Yes	3	9	9
107	R:R:I132	R:R:Y298	6.04	No	Yes	3	9	9
108	R:R:E135	R:R:T139	7.06	Yes	No	7	9	8
109	R:R:R136	R:R:Y215	5.14	Yes	Yes	0	9	9
110	R:R:R136	R:R:Y298	3.09	Yes	Yes	3	9	9
111	R:R:H137	R:R:L214	7.71	No	No	0	8	6
112	R:R:H137	R:R:R217	6.77	No	No	0	8	6
113	R:R:H137	R:R:I218	3.98	No	No	0	8	8
114	R:R:P145	R:R:Y146	6.95	No	No	0	5	7
115	R:R:A148	R:R:K150	3.21	No	No	0	5	7
116	R:R:K150	R:R:R153	9.9	No	No	0	7	5
117	R:R:I158	R:R:V154	3.07	No	Yes	0	7	7
118	R:R:F166	R:R:W162	9.02	No	Yes	0	4	9
119	R:R:L168	R:R:Y196	5.86	No	Yes	2	5	6
120	R:R:C200	R:R:L168	4.76	Yes	No	2	6	5
121	L:L:?1	R:R:L168	3.13	Yes	No	2	0	5
122	R:R:L171	R:R:P172	4.93	No	Yes	0	6	5
123	R:R:L171	R:R:W176	6.83	No	No	0	6	4
124	R:R:P172	R:R:Y192	8.34	Yes	No	0	5	3
125	R:R:P172	R:R:Y196	22.25	Yes	Yes	0	5	6
126	R:R:I173	R:R:L174	4.28	No	No	0	5	4
127	R:R:K195	R:R:W176	10.44	No	No	0	4	4
128	R:R:W176	R:R:Y196	4.82	No	Yes	0	4	6
129	R:R:C178	R:R:C185	7.28	No	No	0	5	9
130	R:R:H180	R:R:L179	12.86	No	No	0	1	3
131	R:R:N181	R:R:P183	11.4	No	No	0	3	4
132	R:R:C185	R:R:L182	3.17	No	Yes	1	9	3
133	R:R:D184	R:R:P183	4.83	No	No	0	3	4
134	R:R:D184	R:R:S193	5.89	No	No	0	3	5
135	R:R:D184	R:R:K194	5.53	No	No	0	3	3
136	R:R:I197	R:R:S186	3.1	No	No	0	6	5
137	R:R:D266	R:R:S186	5.89	Yes	No	0	4	5
138	R:R:L277	R:R:T187	4.42	Yes	No	0	2	5
139	R:R:I188	R:R:L189	4.28	Yes	No	1	4	5
140	R:R:D266	R:R:I188	5.6	Yes	Yes	1	4	4
141	R:R:I188	R:R:L277	4.28	Yes	Yes	1	4	2
142	R:R:A280	R:R:I188	4.87	No	Yes	0	4	4
143	R:R:L189	R:R:Y192	7.03	No	No	1	5	3
144	R:R:C200	R:R:Y196	6.72	Yes	Yes	2	6	6
145	R:R:I197	R:R:I201	2.94	No	No	0	6	4
146	R:R:I197	R:R:V267	3.07	No	No	0	6	4
147	L:L:?1	R:R:C200	7.18	Yes	Yes	2	0	6
148	R:R:F260	R:R:I201	3.77	Yes	No	0	6	4
149	L:L:?1	R:R:I201	3.23	Yes	No	0	0	4
150	R:R:I203	R:R:I207	2.94	No	No	0	5	7
151	L:L:?1	R:R:I203	4.31	Yes	No	0	0	5
152	R:R:F204	R:R:W256	8.02	No	Yes	2	7	8
153	R:R:F204	R:R:F260	7.5	No	Yes	0	7	6
154	L:L:?1	R:R:F204	11.02	Yes	No	2	0	7
155	R:R:I207	R:R:I211	2.94	No	No	8	7	8
156	R:R:F252	R:R:L208	4.87	No	No	0	9	6
157	R:R:V245	R:R:Y215	5.05	No	Yes	0	8	9
158	R:R:V248	R:R:Y215	5.05	No	Yes	0	8	9
159	R:R:V249	R:R:Y215	3.79	No	Yes	0	8	9
160	R:R:F220	R:R:Y219	4.13	No	Yes	0	1	6
161	R:R:L241	R:R:Y219	3.52	No	Yes	0	8	6
162	R:R:L242	R:R:Y219	14.07	No	Yes	0	7	6
163	R:R:L241	R:R:V222	4.47	No	No	0	8	8
164	R:R:K223	R:R:S238	3.06	No	No	0	5	7
165	R:R:N234	R:R:S226	5.96	Yes	No	0	4	5
166	R:R:N231	R:R:V229	5.91	No	No	9	5	7
167	R:R:N234	R:R:V229	5.91	Yes	No	9	4	7
168	R:R:N231	R:R:N234	8.17	No	Yes	9	5	4
169	R:R:H232	R:R:N233	3.83	No	No	0	3	4
170	R:R:N234	R:R:R237	8.44	Yes	No	0	4	4
171	R:R:L241	R:R:V245	2.98	No	No	0	8	8
172	R:R:I253	R:R:V249	3.07	No	No	0	6	8
173	R:R:M293	R:R:V251	3.04	No	No	0	7	6
174	R:R:I297	R:R:V251	4.61	No	No	0	8	6
175	R:R:F252	R:R:W256	8.02	No	Yes	0	9	8
176	R:R:I253	R:R:S257	3.1	No	No	0	6	5
177	R:R:C255	R:R:N290	6.3	No	No	0	9	9
178	R:R:N290	R:R:W256	12.43	No	Yes	0	9	8
179	L:L:?1	R:R:W256	6.01	Yes	Yes	2	0	8
180	R:R:L286	R:R:P258	6.57	No	No	0	7	9
181	R:R:F263	R:R:L259	10.96	No	Yes	2	6	6
182	R:R:I284	R:R:L259	4.28	No	Yes	0	5	6
183	L:L:?1	R:R:L259	5.22	Yes	Yes	2	0	6
184	R:R:F260	R:R:I261	3.77	Yes	No	0	6	4
185	R:R:I261	R:R:I265	2.94	No	No	0	4	4
186	R:R:F283	R:R:L262	8.53	No	No	0	6	5
187	L:L:?1	R:R:F263	12.86	Yes	No	2	0	6
188	R:R:D266	R:R:L277	5.43	Yes	Yes	1	4	2
189	R:R:C269	R:R:C274	7.28	No	No	10	4	2
190	R:R:K279	R:R:W282	8.12	No	No	0	4	4
191	R:R:N290	R:R:N294	12.26	No	Yes	0	9	9
192	R:R:N294	R:R:Y298	3.49	Yes	Yes	3	9	9
193	R:R:I297	R:R:Y298	4.84	No	Yes	0	8	9
194	R:R:L300	R:R:T299	2.95	Yes	No	0	5	7
195	R:R:M305	R:R:T299	3.01	No	No	0	8	7
196	R:R:L300	R:R:R306	3.64	Yes	No	0	5	8
197	R:R:F309	R:R:L300	4.87	No	Yes	0	6	5
198	R:R:M305	R:R:S302	3.07	No	No	0	8	8
199	R:R:F283	R:R:P258	2.89	No	No	0	6	9
200	R:R:K101	R:R:K102	2.87	No	No	0	2	3
201	R:R:Q272	R:R:V271	2.87	No	No	0	1	1
202	R:R:I49	R:R:L45	2.85	No	No	0	7	4
203	R:R:I62	R:R:L58	2.85	No	No	0	4	4
204	R:R:I134	R:R:L130	2.85	No	Yes	0	7	7
205	R:R:I134	R:R:L214	2.85	No	No	0	7	6
206	R:R:I158	R:R:N80	2.83	No	No	0	7	9
207	R:R:L97	R:R:M98	2.83	No	Yes	0	5	4
208	R:R:L61	R:R:L83	2.77	No	No	0	7	6
209	R:R:A63	R:R:F309	2.77	No	No	0	7	6
210	R:R:A131	R:R:F77	2.77	No	Yes	0	7	8
211	R:R:D266	R:R:K194	2.77	Yes	No	0	4	3
212	R:R:L262	R:R:L277	2.77	No	Yes	0	5	2
213	R:R:L179	R:R:N177	2.75	No	No	0	3	5
214	R:R:H21	R:R:T17	2.74	Yes	No	0	7	6
215	R:R:R114	R:R:S99	2.64	Yes	No	0	6	5
216	R:R:F166	R:R:V120	2.62	No	No	0	4	5
217	R:R:C84	R:R:W162	2.61	No	Yes	0	8	9
218	R:R:F260	R:R:T205	2.59	Yes	No	0	6	3
219	R:R:D147	R:R:H71	2.52	No	No	0	3	8
220	R:R:F46	R:R:I96	2.51	Yes	No	0	7	6
221	R:R:K142	R:R:R144	2.48	No	No	0	5	6
222	R:R:E236	R:R:H232	2.46	No	No	0	4	3
223	R:R:F46	R:R:L45	2.44	Yes	No	0	7	4
224	R:R:L138	R:R:R153	2.43	No	No	0	5	5
225	R:R:I96	R:R:Y92	2.42	No	Yes	0	6	6
226	R:R:L28	R:R:Y22	2.34	No	Yes	0	3	9
227	R:R:N72	R:R:Y75	2.33	No	Yes	0	7	9
228	R:R:E304	R:R:R307	2.33	No	No	0	7	4
229	R:R:G169	R:R:P172	2.03	No	Yes	0	7	5
230	R:R:A88	R:R:G89	1.95	No	No	0	8	7
231	R:R:C274	R:R:P275	1.88	No	No	0	2	2
232	R:R:G89	R:R:V54	1.84	No	No	0	7	6
233	R:R:C127	R:R:C161	1.82	No	No	0	5	7
234	R:R:A273	R:R:C269	1.81	No	No	0	3	4
235	R:R:A121	R:R:A88	1.79	No	No	0	7	8
236	R:R:A124	R:R:A165	1.79	No	No	0	8	8
237	R:R:G89	R:R:I53	1.76	No	Yes	0	7	7
238	R:R:G159	R:R:I158	1.76	No	No	0	3	7
239	R:R:C161	R:R:S128	1.72	No	No	0	7	8
240	R:R:A91	R:R:S117	1.71	No	No	0	5	4
241	R:R:C127	R:R:I164	1.64	No	No	0	5	3
242	R:R:C269	R:R:I265	1.64	No	No	10	4	4
243	R:R:C274	R:R:I265	1.64	No	No	10	2	4
244	R:R:A292	R:R:I53	1.62	No	Yes	0	6	7
245	R:R:A133	R:R:I211	1.62	No	No	0	8	8
246	R:R:V212	R:R:V249	1.6	No	No	0	4	8
247	R:R:T40	R:R:V44	1.59	No	No	0	3	5
248	R:R:T205	R:R:V209	1.59	No	No	0	3	2
249	R:R:T244	R:R:V248	1.59	No	No	0	9	8
250	R:R:A287	R:R:L259	1.58	No	Yes	0	7	6
251	R:R:T42	R:R:T43	1.57	No	No	0	5	6
252	R:R:A308	R:R:N67	1.56	No	No	0	6	7
253	R:R:I213	R:R:V209	1.54	No	No	0	4	2
254	R:R:I247	R:R:V251	1.54	No	No	0	7	6
255	R:R:K93	R:R:S51	1.53	No	No	0	6	4
256	R:R:M118	R:R:S117	1.53	Yes	No	0	6	4
257	R:R:M140	R:R:V222	1.52	No	No	0	9	8
258	R:R:F119	R:R:G116	1.51	Yes	No	0	5	6
259	R:R:L242	R:R:V246	1.49	No	No	0	7	6
260	R:R:L300	R:R:V296	1.49	Yes	No	0	5	6
261	R:R:L47	R:R:T43	1.47	No	No	0	5	6
262	R:R:L113	R:R:T109	1.47	No	No	0	4	1
263	R:R:I164	R:R:M160	1.46	No	No	0	3	3
264	R:R:I62	R:R:K66	1.45	No	No	0	4	5
265	R:R:I141	R:R:K142	1.45	No	No	0	6	5
266	R:R:K102	R:R:M98	1.44	No	Yes	0	3	4
267	R:R:K142	R:R:K150	1.44	No	No	0	5	7
268	R:R:P145	R:R:R144	1.44	No	No	0	5	6
269	R:R:F278	R:R:P275	1.44	No	No	0	1	2
270	R:R:I141	R:R:L221	1.43	No	No	0	6	5
271	R:R:I276	R:R:L277	1.43	No	Yes	0	4	2
272	R:R:L55	R:R:M59	1.41	No	No	0	4	7
273	R:R:L221	R:R:M143	1.41	No	No	0	5	8
274	R:R:L156	R:R:M160	1.41	No	No	0	2	3
275	R:R:H232	R:R:S235	1.39	No	No	0	3	4
276	R:R:A240	R:R:R243	1.38	No	No	0	8	7
277	R:R:A273	R:R:R270	1.38	No	No	0	3	1
278	R:R:L286	R:R:L289	1.38	No	No	0	7	5
279	R:R:A308	R:R:R311	1.38	No	No	0	6	4
280	R:R:E56	R:R:L55	1.33	No	No	0	8	4
281	R:R:F52	R:R:V48	1.31	No	No	0	4	4
282	R:R:S238	R:R:Y219	1.27	No	Yes	0	7	6
283	R:R:K223	R:R:R227	1.24	No	No	0	5	4
284	R:R:F278	R:R:K279	1.24	No	No	0	1	4
285	R:R:K303	R:R:R307	1.24	No	No	0	5	4
286	R:R:F52	R:R:L55	1.22	No	No	0	4	4
287	R:R:F260	R:R:L264	1.22	Yes	No	0	6	5
288	R:R:L28	R:R:R19	1.21	No	No	0	3	1
289	R:R:F155	R:R:F76	1.07	No	Yes	6	1	4
290	R:R:F155	R:R:R151	1.07	No	No	6	1	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H21	5.28	4	1	7
2	R:R:Y22	5.824	5	1	9
3	R:R:F46	4.045	4	0	7
4	R:R:I53	2.76	5	4	7
5	R:R:N57	5.245	4	4	9
6	R:R:R73	8.4675	4	7	5
7	R:R:Y75	6.996	5	5	9
8	R:R:F76	4.46	4	6	4
9	R:R:F77	6.234	5	0	8
10	R:R:D85	7.035	4	4	9
11	R:R:Y92	5.172	5	0	6
12	R:R:M98	3.3675	4	1	4
13	R:R:W111	8.436	5	1	9
14	R:R:F112	7.11	4	1	6
15	R:R:R114	5.225	6	1	6
16	R:R:E115	7.7	4	1	5
17	R:R:M118	5.9475	4	0	6
18	R:R:F119	6.27	4	2	5
19	R:R:L130	4.66	4	8	7
20	R:R:E135	8.31	4	7	9
21	R:R:R136	4.8625	4	3	9
22	R:R:V154	5.68	4	0	7
23	R:R:W162	6.4225	4	0	9
24	R:R:P172	9.3875	4	0	5
25	R:R:L182	5.39	4	1	3
26	R:R:I188	4.7575	4	1	4
27	R:R:Y196	9.786	5	2	6
28	R:R:C200	5.7125	4	2	6
29	R:R:Y215	4.7575	4	0	9
30	R:R:Y219	5.7475	4	0	6
31	R:R:N234	7.12	4	9	4
32	R:R:W256	7.866	5	2	8
33	R:R:L259	5.51	4	2	6
34	R:R:F260	3.77	5	0	6
35	R:R:D266	4.9225	4	1	4
36	R:R:L277	3.666	5	1	2
37	R:R:N294	6.685	4	3	9
38	R:R:Y298	4.88333	6	3	9
39	R:R:L300	3.2375	4	0	5
40	L:L:?1	6.61692	13	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H21	R:R:L191	13.5647	11.57	Yes	No	1	7	4
2	R:R:L191	R:R:W111	14.4474	11.39	No	Yes	1	4	9
3	R:R:L18	R:R:W111	11.7194	3.42	No	Yes	1	7	9
4	R:R:R114	R:R:W111	29.7258	7	Yes	Yes	1	6	9
5	R:R:N95	R:R:R114	44.2295	6.03	No	Yes	0	6	6
6	R:R:M118	R:R:N95	44.9432	8.41	Yes	No	0	6	6
7	R:R:M118	R:R:Y92	27.9463	9.58	Yes	Yes	0	6	6
8	R:R:C50	R:R:Y92	11.7523	4.03	No	Yes	0	6	6
9	R:R:C50	R:R:K93	10.3155	3.23	No	No	0	6	6
10	R:R:I53	R:R:V288	11.4659	3.07	Yes	No	0	7	7
11	R:R:V288	R:R:Y92	11.001	3.79	No	Yes	0	7	6
12	R:R:G89	R:R:I53	10.3014	1.76	No	Yes	0	7	7
13	R:R:I64	R:R:V60	16.2785	3.07	No	No	0	8	9
14	R:R:I64	R:R:I78	18.8609	2.94	No	No	0	8	8
15	R:R:I78	R:R:Y298	20.138	3.63	No	Yes	0	8	9
16	R:R:N294	R:R:Y298	100	3.49	Yes	Yes	3	9	9
17	R:R:N290	R:R:N294	90.9945	12.26	No	Yes	0	9	9
18	R:R:N290	R:R:W256	91.032	12.43	No	Yes	0	9	8
19	L:L:?1	R:R:W256	80.2986	6.01	Yes	Yes	2	0	8
20	L:L:?1	R:R:M118	59.6629	4.27	Yes	Yes	0	0	6
21	R:R:L300	R:R:T299	11.8274	2.95	Yes	No	0	5	7
22	R:R:M305	R:R:T299	13.0951	3.01	No	No	0	8	7
23	R:R:M305	R:R:Y75	15.5414	8.38	No	Yes	0	8	9
24	R:R:N72	R:R:Y75	25.1432	2.33	No	Yes	0	7	9
25	R:R:M74	R:R:N72	26.3076	4.21	No	No	0	8	7
26	R:R:M74	R:R:R136	36.9518	4.96	No	Yes	0	8	9
27	R:R:R136	R:R:Y298	51.3851	3.09	Yes	Yes	3	9	9
28	R:R:F77	R:R:V154	27.6646	9.18	Yes	Yes	0	8	7
29	R:R:F77	R:R:I132	42.018	5.02	Yes	No	0	8	9
30	R:R:I132	R:R:Y298	41.2433	6.04	No	Yes	3	9	9
31	R:R:E135	R:R:M74	18.7858	4.06	Yes	No	0	9	8
32	R:R:E135	R:R:F77	15.1094	9.33	Yes	Yes	0	9	8
33	R:R:E135	R:R:R73	26.2278	12.79	Yes	Yes	7	9	5
34	R:R:R73	R:R:V154	13.7055	6.54	Yes	Yes	0	5	7
35	R:R:R153	R:R:R73	33.8201	10.66	No	Yes	0	5	5
36	R:R:I158	R:R:V154	12.2077	3.07	No	Yes	0	7	7
37	R:R:L81	R:R:N294	21.6734	4.12	No	Yes	0	9	9
38	L:L:?1	R:R:F119	11.0809	10.1	Yes	Yes	2	0	5
39	R:R:P172	R:R:Y196	15.147	22.25	Yes	Yes	0	5	6
40	R:R:I203	R:R:I207	13.9872	2.94	No	No	0	5	7
41	L:L:?1	R:R:I203	15.3348	4.31	Yes	No	0	0	5
42	R:R:R136	R:R:Y215	21.2039	5.14	Yes	Yes	0	9	9
43	R:R:K150	R:R:R153	27.8946	9.9	No	No	0	7	5
44	R:R:K142	R:R:K150	21.6264	1.44	No	No	0	5	7
45	R:R:I197	R:R:I201	19.368	2.94	No	No	0	6	4
46	L:L:?1	R:R:I201	26.9744	3.23	Yes	No	0	0	4
47	R:R:D266	R:R:S186	16.7246	5.89	Yes	No	0	4	5
48	R:R:I197	R:R:S186	17.3678	3.1	No	No	0	6	5
49	R:R:F204	R:R:F260	18.1238	7.5	No	Yes	0	7	6
50	R:R:V245	R:R:Y215	13.3909	5.05	No	Yes	0	8	9
51	R:R:L241	R:R:V245	12.1842	2.98	No	No	0	8	8
52	R:R:F260	R:R:I261	18.7764	3.77	Yes	No	0	6	4
53	R:R:I261	R:R:I265	16.9406	2.94	No	No	0	4	4
54	R:R:D85	R:R:L81	14.9357	9.5	Yes	No	0	9	9
55	R:R:F204	R:R:W256	10.4376	8.02	No	Yes	2	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M118	R:R:Y92	9.58	0	Yes	Yes	6	6	1	2
R:R:I284	R:R:Y92	6.04	0	No	Yes	5	6	2	2
R:R:M118	R:R:N95	8.41	0	Yes	No	6	6	1	2
L:L:?1	R:R:M118	4.27	2	Yes	Yes	0	6	0	1
R:R:F119	R:R:Y196	9.28	2	Yes	Yes	5	6	1	2
R:R:C200	R:R:F119	4.19	2	Yes	Yes	6	5	1	1
L:L:?1	R:R:F119	10.1	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:L122	11.48	2	Yes	No	0	6	0	1
L:L:?1	R:R:G123	3.87	2	Yes	No	0	5	0	1
R:R:T126	R:R:W256	4.85	2	No	Yes	7	8	1	1
L:L:?1	R:R:T126	3.34	2	Yes	No	0	7	0	1
R:R:L168	R:R:Y196	5.86	2	No	Yes	5	6	1	2
R:R:C200	R:R:L168	4.76	2	Yes	No	6	5	1	1
L:L:?1	R:R:L168	3.13	2	Yes	No	0	5	0	1
R:R:C200	R:R:Y196	6.72	2	Yes	Yes	6	6	1	2
R:R:I197	R:R:I201	2.94	0	No	No	6	4	2	1
L:L:?1	R:R:C200	7.18	2	Yes	Yes	0	6	0	1
R:R:F260	R:R:I201	3.77	0	Yes	No	6	4	2	1
L:L:?1	R:R:I201	3.23	2	Yes	No	0	4	0	1
R:R:I203	R:R:I207	2.94	0	No	No	5	7	1	2
L:L:?1	R:R:I203	4.31	2	Yes	No	0	5	0	1
R:R:F204	R:R:W256	8.02	2	No	Yes	7	8	1	1
R:R:F204	R:R:F260	7.5	2	No	Yes	7	6	1	2
L:L:?1	R:R:F204	11.02	2	Yes	No	0	7	0	1
R:R:F252	R:R:W256	8.02	0	No	Yes	9	8	2	1
R:R:N290	R:R:W256	12.43	0	No	Yes	9	8	2	1
L:L:?1	R:R:W256	6.01	2	Yes	Yes	0	8	0	1
R:R:F263	R:R:L259	10.96	2	No	Yes	6	6	1	1
R:R:I284	R:R:L259	4.28	0	No	Yes	5	6	2	1
L:L:?1	R:R:L259	5.22	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:F263	12.86	2	Yes	No	0	6	0	1
R:R:A287	R:R:L259	1.58	0	No	Yes	7	6	2	1
R:R:M118	R:R:S117	1.53	0	Yes	No	6	4	1	2
R:R:F119	R:R:G116	1.51	2	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EW4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.94
Number of Linked Nodes	262
Number of Links	290
Number of Hubs	40
Number of Links mediated by Hubs	154
Number of Communities	10
Number of Nodes involved in Communities	56
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	42198
Length Of Smallest Path	3
Average Path Length	12.2787
Length of Longest Path	29
Minimum Path Strength	1.265
Average Path Strength	5.79324
Maximum Path Strength	15.765
Minimum Path Correlation	0.7
Average Path Correlation	0.920144
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	47.4043
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.0825
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cell adhesion molecule binding • integrin binding • signaling receptor binding • lipid binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • bioactive lipid receptor activity • sphingosine-1-phosphate receptor activity • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • regulation of establishment of endothelial barrier • cellular developmental process • regulation of developmental process • endothelium development • negative regulation of biological process • cell development • regulation of cell differentiation • negative regulation of endothelial cell development • epithelial cell differentiation • regulation of cell development • regulation of epithelial cell differentiation • endothelial cell development • cell differentiation • regulation of endothelial cell development • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of cell differentiation • epithelium development • regulation of multicellular organismal development • negative regulation of epithelial cell differentiation • endothelial cell differentiation • regulation of endothelial cell differentiation • negative regulation of developmental process • negative regulation of endothelial cell differentiation • tissue development • negative regulation of cell development • epithelial cell development • establishment of endothelial barrier • negative regulation of establishment of endothelial barrier • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • defense response • response to stress • inflammatory response • regulation of biosynthetic process • regulation of interleukin-1 production • interleukin-1 production • regulation of macromolecule metabolic process • gene expression • regulation of interleukin-1 beta production • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • interleukin-1 beta production • regulation of cytokine production • cytokine production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • cell surface receptor signaling pathway • Notch signaling pathway • anatomical structure morphogenesis • presynapse
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JF9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	JF9
Name	N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
Synonyms
Identifier
Formula	C19 H28 N2 O2
Molecular Weight	316.438
SMILES
PubChem	17253208
Formal Charge	0
Total Atoms	51
Total Chiral Atoms	0
Total Bonds	54
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99500
Sequence	>7EW4_nogp_Chain_R E T L R E H Y Q Y V G K L S T L T T V L F L V I C S F I V L E N L M V L I A I W K N N K F H N R M Y F F I G N L A L C D L L A G I A Y K V N I L M S G K K T F S L S P T V W F L R E G S M F V A L G A S T C S L L A I A I E R H L T M I K M R P Y D A N K R H R V F L L I G M C W L I A F T L G A L P I L G W N C L H N L P D C S T I L P L Y S K K Y I A F C I S I F T A I L V T I V I L Y A R I Y F L V K S S S R K V A N H N N S E R S M A L L R T V V I V V S V F I A C W S P L F I L F L I D V A C R V Q A C P I L F K A Q W F I V L A V L N S A M N P V I Y T L A S K E M R R A F F R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7C4S	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	-	3.2	2021-06-09	doi.org/10.1126/sciadv.abf5325
	7EW2	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	FTY720-P	-		3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW3	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	Gi1/β1/γ2	3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-		3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW4	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	CYM-5541	-	Gi1/β1/γ2	3.2	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	CYM-5541	-		3.2	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	9L74	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P d16:1	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.73	2025-11-26	10.1073/pnas.2507421122
	9L74 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P d16:1	-		3.73	2025-11-26	10.1073/pnas.2507421122
	9WP9	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2025-11-26	10.1073/pnas.2507421122
	9WP9 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-		3.25	2025-11-26	10.1073/pnas.2507421122

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.