psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L18	R:R:Y22	3.52	No	Yes	1	7	9
2	R:R:F104	R:R:L18	3.65	No	No	1	7	7
3	R:R:L18	R:R:W111	3.42	No	Yes	1	7	9
4	R:R:E20	R:R:L182	3.98	No	Yes	0	2	3
5	R:R:H21	R:R:L182	3.86	Yes	Yes	1	7	3
6	R:R:C185	R:R:H21	2.95	No	Yes	1	9	7
7	R:R:H21	R:R:L191	11.57	Yes	No	1	7	4
8	R:R:K27	R:R:Y22	8.36	No	Yes	0	7	9
9	R:R:F104	R:R:Y22	5.16	No	Yes	1	7	9
10	R:R:P190	R:R:Y22	9.74	No	Yes	0	4	9
11	R:R:L28	R:R:Q23	14.64	No	No	0	3	7
12	R:R:L182	R:R:Y24	10.55	Yes	No	0	3	5
13	R:R:V271	R:R:Y24	5.05	No	No	0	1	5
14	R:R:T187	R:R:V25	3.17	No	No	0	5	6
15	R:R:P190	R:R:V25	3.53	No	No	0	4	6
16	R:R:G26	R:R:Q272	4.93	No	No	0	6	1
17	R:R:L41	R:R:S39	3	No	No	0	4	3
18	R:R:S39	R:R:T42	3.2	No	No	0	3	5
19	R:R:F46	R:R:Q281	4.68	Yes	No	0	7	4
20	R:R:F46	R:R:V285	6.55	Yes	No	0	7	4
21	R:R:K93	R:R:L47	4.23	No	No	0	6	5
22	R:R:C50	R:R:Y92	4.03	No	Yes	0	6	6
23	R:R:C50	R:R:K93	3.23	No	No	0	6	6
24	R:R:I53	R:R:N57	4.25	Yes	Yes	4	7	9
25	R:R:I53	R:R:V288	3.07	Yes	No	0	7	7
26	R:R:I53	R:R:S291	3.1	Yes	No	4	7	9
27	R:R:I90	R:R:V54	4.61	No	No	0	5	6
28	R:R:E56	R:R:P295	11	No	No	0	8	9
29	R:R:D85	R:R:N57	5.39	Yes	Yes	4	9	9
30	R:R:L86	R:R:N57	6.87	No	Yes	0	7	9
31	R:R:N57	R:R:S291	4.47	Yes	No	4	9	9
32	R:R:I64	R:R:V60	3.07	No	No	0	8	9
33	R:R:A82	R:R:V60	3.39	No	No	0	9	9
34	R:R:P295	R:R:V60	3.53	No	No	0	9	9
35	R:R:L61	R:R:W65	3.42	No	No	0	7	3
36	R:R:A82	R:R:L61	3.15	No	No	0	9	7
37	R:R:A63	R:R:L312	3.15	No	No	0	7	6
38	R:R:I64	R:R:I78	2.94	No	No	0	8	8
39	R:R:G79	R:R:I64	3.53	No	No	0	6	8
40	R:R:K66	R:R:L312	12.69	No	No	0	5	6
41	R:R:K69	R:R:N67	8.39	No	No	5	6	7
42	R:R:N67	R:R:Y75	11.63	No	Yes	5	7	9
43	R:R:K69	R:R:Y75	4.78	No	Yes	5	6	9
44	R:R:E304	R:R:K69	4.05	No	No	5	7	6
45	R:R:F70	R:R:F76	5.36	No	Yes	0	8	4
46	R:R:M74	R:R:N72	4.21	No	No	0	8	7
47	R:R:E135	R:R:R73	12.79	Yes	Yes	7	9	5
48	R:R:R73	R:R:T139	3.88	Yes	No	7	5	8
49	R:R:R153	R:R:R73	10.66	No	Yes	0	5	5
50	R:R:R73	R:R:V154	6.54	Yes	Yes	0	5	7
51	R:R:E135	R:R:M74	4.06	Yes	No	0	9	8
52	R:R:M74	R:R:R136	4.96	No	Yes	0	8	9
53	R:R:E304	R:R:Y75	7.86	No	Yes	5	7	9
54	R:R:M305	R:R:Y75	8.38	No	Yes	0	8	9
55	R:R:F76	R:R:R151	7.48	Yes	No	6	4	2
56	R:R:F76	R:R:V154	3.93	Yes	Yes	0	4	7
57	R:R:F77	R:R:I132	5.02	Yes	No	0	8	9
58	R:R:E135	R:R:F77	9.33	Yes	Yes	0	9	8
59	R:R:F77	R:R:V154	9.18	Yes	Yes	0	8	7
60	R:R:F77	R:R:L157	4.87	Yes	No	0	8	6
61	R:R:I78	R:R:Y298	3.63	No	Yes	0	8	9
62	R:R:N80	R:R:W162	10.17	No	Yes	0	9	9
63	R:R:D85	R:R:L81	9.5	Yes	No	0	9	9
64	R:R:L81	R:R:S128	6.01	No	No	0	9	8
65	R:R:L81	R:R:N294	4.12	No	Yes	0	9	9
66	R:R:L83	R:R:L87	5.54	No	No	0	6	7
67	R:R:D85	R:R:S125	5.89	Yes	No	0	9	9
68	R:R:D85	R:R:S291	7.36	Yes	No	4	9	9
69	R:R:M118	R:R:Y92	9.58	Yes	Yes	0	6	6
70	R:R:I284	R:R:Y92	6.04	No	Yes	0	5	6
71	R:R:V288	R:R:Y92	3.79	No	Yes	0	7	6
72	R:R:N95	R:R:R114	6.03	No	Yes	0	6	6
73	R:R:M118	R:R:N95	8.41	Yes	No	0	6	6
74	R:R:L106	R:R:M98	4.24	No	Yes	1	6	4
75	R:R:M98	R:R:R114	4.96	Yes	Yes	1	4	6
76	R:R:F104	R:R:T103	9.08	No	No	0	7	5
77	R:R:L106	R:R:V110	7.45	No	No	0	6	6
78	R:R:L106	R:R:R114	6.07	No	Yes	1	6	6
79	R:R:P108	R:R:S107	3.56	No	No	0	3	7
80	R:R:S107	R:R:T109	3.2	No	No	0	7	1
81	R:R:S107	R:R:V110	3.23	No	No	0	7	6
82	R:R:F112	R:R:W111	4.01	Yes	Yes	1	6	9
83	R:R:R114	R:R:W111	7	Yes	Yes	1	6	9
84	R:R:E115	R:R:W111	16.36	Yes	Yes	1	5	9
85	R:R:L191	R:R:W111	11.39	No	Yes	1	4	9
86	R:R:F112	R:R:I173	5.02	Yes	No	0	6	5
87	R:R:F112	R:R:N177	9.67	Yes	No	0	6	5
88	R:R:F112	R:R:L191	9.74	Yes	No	1	6	4
89	R:R:E115	R:R:R114	4.65	Yes	Yes	1	5	6
90	R:R:E115	R:R:L189	5.3	Yes	No	1	5	5
91	R:R:E115	R:R:Y192	4.49	Yes	No	1	5	3
92	L:L:?1	R:R:M118	4.27	Yes	Yes	0	0	6
93	R:R:F119	R:R:Y196	9.28	Yes	Yes	2	5	6
94	R:R:C200	R:R:F119	4.19	Yes	Yes	2	6	5
95	L:L:?1	R:R:F119	10.1	Yes	Yes	2	0	5
96	L:L:?1	R:R:L122	11.48	Yes	No	0	0	6
97	L:L:?1	R:R:G123	3.87	Yes	No	0	0	5
98	R:R:A124	R:R:W162	3.89	No	Yes	0	8	9
99	R:R:T126	R:R:W256	4.85	No	Yes	2	7	8
100	L:L:?1	R:R:T126	3.34	Yes	No	2	0	7
101	R:R:L129	R:R:N294	6.87	No	Yes	3	9	9
102	R:R:L129	R:R:Y298	8.21	No	Yes	3	9	9
103	R:R:I207	R:R:L130	8.56	No	Yes	8	7	7
104	R:R:L130	R:R:T210	2.95	Yes	No	0	7	6
105	R:R:I211	R:R:L130	4.28	No	Yes	8	8	7
106	R:R:I132	R:R:R136	6.26	No	Yes	3	9	9
107	R:R:I132	R:R:Y298	6.04	No	Yes	3	9	9
108	R:R:E135	R:R:T139	7.06	Yes	No	7	9	8
109	R:R:R136	R:R:Y215	5.14	Yes	Yes	0	9	9
110	R:R:R136	R:R:Y298	3.09	Yes	Yes	3	9	9
111	R:R:H137	R:R:L214	7.71	No	No	0	8	6
112	R:R:H137	R:R:R217	6.77	No	No	0	8	6
113	R:R:H137	R:R:I218	3.98	No	No	0	8	8
114	R:R:P145	R:R:Y146	6.95	No	No	0	5	7
115	R:R:A148	R:R:K150	3.21	No	No	0	5	7
116	R:R:K150	R:R:R153	9.9	No	No	0	7	5
117	R:R:I158	R:R:V154	3.07	No	Yes	0	7	7
118	R:R:F166	R:R:W162	9.02	No	Yes	0	4	9
119	R:R:L168	R:R:Y196	5.86	No	Yes	2	5	6
120	R:R:C200	R:R:L168	4.76	Yes	No	2	6	5
121	L:L:?1	R:R:L168	3.13	Yes	No	2	0	5
122	R:R:L171	R:R:P172	4.93	No	Yes	0	6	5
123	R:R:L171	R:R:W176	6.83	No	No	0	6	4
124	R:R:P172	R:R:Y192	8.34	Yes	No	0	5	3
125	R:R:P172	R:R:Y196	22.25	Yes	Yes	0	5	6
126	R:R:I173	R:R:L174	4.28	No	No	0	5	4
127	R:R:K195	R:R:W176	10.44	No	No	0	4	4
128	R:R:W176	R:R:Y196	4.82	No	Yes	0	4	6
129	R:R:C178	R:R:C185	7.28	No	No	0	5	9
130	R:R:H180	R:R:L179	12.86	No	No	0	1	3
131	R:R:N181	R:R:P183	11.4	No	No	0	3	4
132	R:R:C185	R:R:L182	3.17	No	Yes	1	9	3
133	R:R:D184	R:R:P183	4.83	No	No	0	3	4
134	R:R:D184	R:R:S193	5.89	No	No	0	3	5
135	R:R:D184	R:R:K194	5.53	No	No	0	3	3
136	R:R:I197	R:R:S186	3.1	No	No	0	6	5
137	R:R:D266	R:R:S186	5.89	Yes	No	0	4	5
138	R:R:L277	R:R:T187	4.42	Yes	No	0	2	5
139	R:R:I188	R:R:L189	4.28	Yes	No	1	4	5
140	R:R:D266	R:R:I188	5.6	Yes	Yes	1	4	4
141	R:R:I188	R:R:L277	4.28	Yes	Yes	1	4	2
142	R:R:A280	R:R:I188	4.87	No	Yes	0	4	4
143	R:R:L189	R:R:Y192	7.03	No	No	1	5	3
144	R:R:C200	R:R:Y196	6.72	Yes	Yes	2	6	6
145	R:R:I197	R:R:I201	2.94	No	No	0	6	4
146	R:R:I197	R:R:V267	3.07	No	No	0	6	4
147	L:L:?1	R:R:C200	7.18	Yes	Yes	2	0	6
148	R:R:F260	R:R:I201	3.77	Yes	No	0	6	4
149	L:L:?1	R:R:I201	3.23	Yes	No	0	0	4
150	R:R:I203	R:R:I207	2.94	No	No	0	5	7
151	L:L:?1	R:R:I203	4.31	Yes	No	0	0	5
152	R:R:F204	R:R:W256	8.02	No	Yes	2	7	8
153	R:R:F204	R:R:F260	7.5	No	Yes	0	7	6
154	L:L:?1	R:R:F204	11.02	Yes	No	2	0	7
155	R:R:I207	R:R:I211	2.94	No	No	8	7	8
156	R:R:F252	R:R:L208	4.87	No	No	0	9	6
157	R:R:V245	R:R:Y215	5.05	No	Yes	0	8	9
158	R:R:V248	R:R:Y215	5.05	No	Yes	0	8	9
159	R:R:V249	R:R:Y215	3.79	No	Yes	0	8	9
160	R:R:F220	R:R:Y219	4.13	No	Yes	0	1	6
161	R:R:L241	R:R:Y219	3.52	No	Yes	0	8	6
162	R:R:L242	R:R:Y219	14.07	No	Yes	0	7	6
163	R:R:L241	R:R:V222	4.47	No	No	0	8	8
164	R:R:K223	R:R:S238	3.06	No	No	0	5	7
165	R:R:N234	R:R:S226	5.96	Yes	No	0	4	5
166	R:R:N231	R:R:V229	5.91	No	No	9	5	7
167	R:R:N234	R:R:V229	5.91	Yes	No	9	4	7
168	R:R:N231	R:R:N234	8.17	No	Yes	9	5	4
169	R:R:H232	R:R:N233	3.83	No	No	0	3	4
170	R:R:N234	R:R:R237	8.44	Yes	No	0	4	4
171	R:R:L241	R:R:V245	2.98	No	No	0	8	8
172	R:R:I253	R:R:V249	3.07	No	No	0	6	8
173	R:R:M293	R:R:V251	3.04	No	No	0	7	6
174	R:R:I297	R:R:V251	4.61	No	No	0	8	6
175	R:R:F252	R:R:W256	8.02	No	Yes	0	9	8
176	R:R:I253	R:R:S257	3.1	No	No	0	6	5
177	R:R:C255	R:R:N290	6.3	No	No	0	9	9
178	R:R:N290	R:R:W256	12.43	No	Yes	0	9	8
179	L:L:?1	R:R:W256	6.01	Yes	Yes	2	0	8
180	R:R:L286	R:R:P258	6.57	No	No	0	7	9
181	R:R:F263	R:R:L259	10.96	No	Yes	2	6	6
182	R:R:I284	R:R:L259	4.28	No	Yes	0	5	6
183	L:L:?1	R:R:L259	5.22	Yes	Yes	2	0	6
184	R:R:F260	R:R:I261	3.77	Yes	No	0	6	4
185	R:R:I261	R:R:I265	2.94	No	No	0	4	4
186	R:R:F283	R:R:L262	8.53	No	No	0	6	5
187	L:L:?1	R:R:F263	12.86	Yes	No	2	0	6
188	R:R:D266	R:R:L277	5.43	Yes	Yes	1	4	2
189	R:R:C269	R:R:C274	7.28	No	No	10	4	2
190	R:R:K279	R:R:W282	8.12	No	No	0	4	4
191	R:R:N290	R:R:N294	12.26	No	Yes	0	9	9
192	R:R:N294	R:R:Y298	3.49	Yes	Yes	3	9	9
193	R:R:I297	R:R:Y298	4.84	No	Yes	0	8	9
194	R:R:L300	R:R:T299	2.95	Yes	No	0	5	7
195	R:R:M305	R:R:T299	3.01	No	No	0	8	7
196	R:R:L300	R:R:R306	3.64	Yes	No	0	5	8
197	R:R:F309	R:R:L300	4.87	No	Yes	0	6	5
198	R:R:M305	R:R:S302	3.07	No	No	0	8	8
199	R:R:F283	R:R:P258	2.89	No	No	0	6	9
200	R:R:K101	R:R:K102	2.87	No	No	0	2	3
201	R:R:Q272	R:R:V271	2.87	No	No	0	1	1
202	R:R:I49	R:R:L45	2.85	No	No	0	7	4
203	R:R:I62	R:R:L58	2.85	No	No	0	4	4
204	R:R:I134	R:R:L130	2.85	No	Yes	0	7	7
205	R:R:I134	R:R:L214	2.85	No	No	0	7	6
206	R:R:I158	R:R:N80	2.83	No	No	0	7	9
207	R:R:L97	R:R:M98	2.83	No	Yes	0	5	4
208	R:R:L61	R:R:L83	2.77	No	No	0	7	6
209	R:R:A63	R:R:F309	2.77	No	No	0	7	6
210	R:R:A131	R:R:F77	2.77	No	Yes	0	7	8
211	R:R:D266	R:R:K194	2.77	Yes	No	0	4	3
212	R:R:L262	R:R:L277	2.77	No	Yes	0	5	2
213	R:R:L179	R:R:N177	2.75	No	No	0	3	5
214	R:R:H21	R:R:T17	2.74	Yes	No	0	7	6
215	R:R:R114	R:R:S99	2.64	Yes	No	0	6	5
216	R:R:F166	R:R:V120	2.62	No	No	0	4	5
217	R:R:C84	R:R:W162	2.61	No	Yes	0	8	9
218	R:R:F260	R:R:T205	2.59	Yes	No	0	6	3
219	R:R:D147	R:R:H71	2.52	No	No	0	3	8
220	R:R:F46	R:R:I96	2.51	Yes	No	0	7	6
221	R:R:K142	R:R:R144	2.48	No	No	0	5	6
222	R:R:E236	R:R:H232	2.46	No	No	0	4	3
223	R:R:F46	R:R:L45	2.44	Yes	No	0	7	4
224	R:R:L138	R:R:R153	2.43	No	No	0	5	5
225	R:R:I96	R:R:Y92	2.42	No	Yes	0	6	6
226	R:R:L28	R:R:Y22	2.34	No	Yes	0	3	9
227	R:R:N72	R:R:Y75	2.33	No	Yes	0	7	9
228	R:R:E304	R:R:R307	2.33	No	No	0	7	4
229	R:R:G169	R:R:P172	2.03	No	Yes	0	7	5
230	R:R:A88	R:R:G89	1.95	No	No	0	8	7
231	R:R:C274	R:R:P275	1.88	No	No	0	2	2
232	R:R:G89	R:R:V54	1.84	No	No	0	7	6
233	R:R:C127	R:R:C161	1.82	No	No	0	5	7
234	R:R:A273	R:R:C269	1.81	No	No	0	3	4
235	R:R:A121	R:R:A88	1.79	No	No	0	7	8
236	R:R:A124	R:R:A165	1.79	No	No	0	8	8
237	R:R:G89	R:R:I53	1.76	No	Yes	0	7	7
238	R:R:G159	R:R:I158	1.76	No	No	0	3	7
239	R:R:C161	R:R:S128	1.72	No	No	0	7	8
240	R:R:A91	R:R:S117	1.71	No	No	0	5	4
241	R:R:C127	R:R:I164	1.64	No	No	0	5	3
242	R:R:C269	R:R:I265	1.64	No	No	10	4	4
243	R:R:C274	R:R:I265	1.64	No	No	10	2	4
244	R:R:A292	R:R:I53	1.62	No	Yes	0	6	7
245	R:R:A133	R:R:I211	1.62	No	No	0	8	8
246	R:R:V212	R:R:V249	1.6	No	No	0	4	8
247	R:R:T40	R:R:V44	1.59	No	No	0	3	5
248	R:R:T205	R:R:V209	1.59	No	No	0	3	2
249	R:R:T244	R:R:V248	1.59	No	No	0	9	8
250	R:R:A287	R:R:L259	1.58	No	Yes	0	7	6
251	R:R:T42	R:R:T43	1.57	No	No	0	5	6
252	R:R:A308	R:R:N67	1.56	No	No	0	6	7
253	R:R:I213	R:R:V209	1.54	No	No	0	4	2
254	R:R:I247	R:R:V251	1.54	No	No	0	7	6
255	R:R:K93	R:R:S51	1.53	No	No	0	6	4
256	R:R:M118	R:R:S117	1.53	Yes	No	0	6	4
257	R:R:M140	R:R:V222	1.52	No	No	0	9	8
258	R:R:F119	R:R:G116	1.51	Yes	No	0	5	6
259	R:R:L242	R:R:V246	1.49	No	No	0	7	6
260	R:R:L300	R:R:V296	1.49	Yes	No	0	5	6
261	R:R:L47	R:R:T43	1.47	No	No	0	5	6
262	R:R:L113	R:R:T109	1.47	No	No	0	4	1
263	R:R:I164	R:R:M160	1.46	No	No	0	3	3
264	R:R:I62	R:R:K66	1.45	No	No	0	4	5
265	R:R:I141	R:R:K142	1.45	No	No	0	6	5
266	R:R:K102	R:R:M98	1.44	No	Yes	0	3	4
267	R:R:K142	R:R:K150	1.44	No	No	0	5	7
268	R:R:P145	R:R:R144	1.44	No	No	0	5	6
269	R:R:F278	R:R:P275	1.44	No	No	0	1	2
270	R:R:I141	R:R:L221	1.43	No	No	0	6	5
271	R:R:I276	R:R:L277	1.43	No	Yes	0	4	2
272	R:R:L55	R:R:M59	1.41	No	No	0	4	7
273	R:R:L221	R:R:M143	1.41	No	No	0	5	8
274	R:R:L156	R:R:M160	1.41	No	No	0	2	3
275	R:R:H232	R:R:S235	1.39	No	No	0	3	4
276	R:R:A240	R:R:R243	1.38	No	No	0	8	7
277	R:R:A273	R:R:R270	1.38	No	No	0	3	1
278	R:R:L286	R:R:L289	1.38	No	No	0	7	5
279	R:R:A308	R:R:R311	1.38	No	No	0	6	4
280	R:R:E56	R:R:L55	1.33	No	No	0	8	4
281	R:R:F52	R:R:V48	1.31	No	No	0	4	4
282	R:R:S238	R:R:Y219	1.27	No	Yes	0	7	6
283	R:R:K223	R:R:R227	1.24	No	No	0	5	4
284	R:R:F278	R:R:K279	1.24	No	No	0	1	4
285	R:R:K303	R:R:R307	1.24	No	No	0	5	4
286	R:R:F52	R:R:L55	1.22	No	No	0	4	4
287	R:R:F260	R:R:L264	1.22	Yes	No	0	6	5
288	R:R:L28	R:R:R19	1.21	No	No	0	3	1
289	R:R:F155	R:R:F76	1.07	No	Yes	6	1	4
290	R:R:F155	R:R:R151	1.07	No	No	6	1	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H21	5.28	4	1	7
2	R:R:Y22	5.824	5	1	9
3	R:R:F46	4.045	4	0	7
4	R:R:I53	2.76	5	4	7
5	R:R:N57	5.245	4	4	9
6	R:R:R73	8.4675	4	7	5
7	R:R:Y75	6.996	5	5	9
8	R:R:F76	4.46	4	6	4
9	R:R:F77	6.234	5	0	8
10	R:R:D85	7.035	4	4	9
11	R:R:Y92	5.172	5	0	6
12	R:R:M98	3.3675	4	1	4
13	R:R:W111	8.436	5	1	9
14	R:R:F112	7.11	4	1	6
15	R:R:R114	5.225	6	1	6
16	R:R:E115	7.7	4	1	5
17	R:R:M118	5.9475	4	0	6
18	R:R:F119	6.27	4	2	5
19	R:R:L130	4.66	4	8	7
20	R:R:E135	8.31	4	7	9
21	R:R:R136	4.8625	4	3	9
22	R:R:V154	5.68	4	0	7
23	R:R:W162	6.4225	4	0	9
24	R:R:P172	9.3875	4	0	5
25	R:R:L182	5.39	4	1	3
26	R:R:I188	4.7575	4	1	4
27	R:R:Y196	9.786	5	2	6
28	R:R:C200	5.7125	4	2	6
29	R:R:Y215	4.7575	4	0	9
30	R:R:Y219	5.7475	4	0	6
31	R:R:N234	7.12	4	9	4
32	R:R:W256	7.866	5	2	8
33	R:R:L259	5.51	4	2	6
34	R:R:F260	3.77	5	0	6
35	R:R:D266	4.9225	4	1	4
36	R:R:L277	3.666	5	1	2
37	R:R:N294	6.685	4	3	9
38	R:R:Y298	4.88333	6	3	9
39	R:R:L300	3.2375	4	0	5
40	L:L:?1	6.61692	13	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H21	R:R:L191	13.5647	11.57	Yes	No	1	7	4
2	R:R:L191	R:R:W111	14.4474	11.39	No	Yes	1	4	9
3	R:R:L18	R:R:W111	11.7194	3.42	No	Yes	1	7	9
4	R:R:R114	R:R:W111	29.7258	7	Yes	Yes	1	6	9
5	R:R:N95	R:R:R114	44.2295	6.03	No	Yes	0	6	6
6	R:R:M118	R:R:N95	44.9432	8.41	Yes	No	0	6	6
7	R:R:M118	R:R:Y92	27.9463	9.58	Yes	Yes	0	6	6
8	R:R:C50	R:R:Y92	11.7523	4.03	No	Yes	0	6	6
9	R:R:C50	R:R:K93	10.3155	3.23	No	No	0	6	6
10	R:R:I53	R:R:V288	11.4659	3.07	Yes	No	0	7	7
11	R:R:V288	R:R:Y92	11.001	3.79	No	Yes	0	7	6
12	R:R:G89	R:R:I53	10.3014	1.76	No	Yes	0	7	7
13	R:R:I64	R:R:V60	16.2785	3.07	No	No	0	8	9
14	R:R:I64	R:R:I78	18.8609	2.94	No	No	0	8	8
15	R:R:I78	R:R:Y298	20.138	3.63	No	Yes	0	8	9
16	R:R:N294	R:R:Y298	100	3.49	Yes	Yes	3	9	9
17	R:R:N290	R:R:N294	90.9945	12.26	No	Yes	0	9	9
18	R:R:N290	R:R:W256	91.032	12.43	No	Yes	0	9	8
19	L:L:?1	R:R:W256	80.2986	6.01	Yes	Yes	2	0	8
20	L:L:?1	R:R:M118	59.6629	4.27	Yes	Yes	0	0	6
21	R:R:L300	R:R:T299	11.8274	2.95	Yes	No	0	5	7
22	R:R:M305	R:R:T299	13.0951	3.01	No	No	0	8	7
23	R:R:M305	R:R:Y75	15.5414	8.38	No	Yes	0	8	9
24	R:R:N72	R:R:Y75	25.1432	2.33	No	Yes	0	7	9
25	R:R:M74	R:R:N72	26.3076	4.21	No	No	0	8	7
26	R:R:M74	R:R:R136	36.9518	4.96	No	Yes	0	8	9
27	R:R:R136	R:R:Y298	51.3851	3.09	Yes	Yes	3	9	9
28	R:R:F77	R:R:V154	27.6646	9.18	Yes	Yes	0	8	7
29	R:R:F77	R:R:I132	42.018	5.02	Yes	No	0	8	9
30	R:R:I132	R:R:Y298	41.2433	6.04	No	Yes	3	9	9
31	R:R:E135	R:R:M74	18.7858	4.06	Yes	No	0	9	8
32	R:R:E135	R:R:F77	15.1094	9.33	Yes	Yes	0	9	8
33	R:R:E135	R:R:R73	26.2278	12.79	Yes	Yes	7	9	5
34	R:R:R73	R:R:V154	13.7055	6.54	Yes	Yes	0	5	7
35	R:R:R153	R:R:R73	33.8201	10.66	No	Yes	0	5	5
36	R:R:I158	R:R:V154	12.2077	3.07	No	Yes	0	7	7
37	R:R:L81	R:R:N294	21.6734	4.12	No	Yes	0	9	9
38	L:L:?1	R:R:F119	11.0809	10.1	Yes	Yes	2	0	5
39	R:R:P172	R:R:Y196	15.147	22.25	Yes	Yes	0	5	6
40	R:R:I203	R:R:I207	13.9872	2.94	No	No	0	5	7
41	L:L:?1	R:R:I203	15.3348	4.31	Yes	No	0	0	5
42	R:R:R136	R:R:Y215	21.2039	5.14	Yes	Yes	0	9	9
43	R:R:K150	R:R:R153	27.8946	9.9	No	No	0	7	5
44	R:R:K142	R:R:K150	21.6264	1.44	No	No	0	5	7
45	R:R:I197	R:R:I201	19.368	2.94	No	No	0	6	4
46	L:L:?1	R:R:I201	26.9744	3.23	Yes	No	0	0	4
47	R:R:D266	R:R:S186	16.7246	5.89	Yes	No	0	4	5
48	R:R:I197	R:R:S186	17.3678	3.1	No	No	0	6	5
49	R:R:F204	R:R:F260	18.1238	7.5	No	Yes	0	7	6
50	R:R:V245	R:R:Y215	13.3909	5.05	No	Yes	0	8	9
51	R:R:L241	R:R:V245	12.1842	2.98	No	No	0	8	8
52	R:R:F260	R:R:I261	18.7764	3.77	Yes	No	0	6	4
53	R:R:I261	R:R:I265	16.9406	2.94	No	No	0	4	4
54	R:R:D85	R:R:L81	14.9357	9.5	Yes	No	0	9	9
55	R:R:F204	R:R:W256	10.4376	8.02	No	Yes	2	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M118	R:R:Y92	9.58	0	Yes	Yes	6	6	1	2
R:R:I284	R:R:Y92	6.04	0	No	Yes	5	6	2	2
R:R:M118	R:R:N95	8.41	0	Yes	No	6	6	1	2
L:L:?1	R:R:M118	4.27	2	Yes	Yes	0	6	0	1
R:R:F119	R:R:Y196	9.28	2	Yes	Yes	5	6	1	2
R:R:C200	R:R:F119	4.19	2	Yes	Yes	6	5	1	1
L:L:?1	R:R:F119	10.1	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:L122	11.48	2	Yes	No	0	6	0	1
L:L:?1	R:R:G123	3.87	2	Yes	No	0	5	0	1
R:R:T126	R:R:W256	4.85	2	No	Yes	7	8	1	1
L:L:?1	R:R:T126	3.34	2	Yes	No	0	7	0	1
R:R:L168	R:R:Y196	5.86	2	No	Yes	5	6	1	2
R:R:C200	R:R:L168	4.76	2	Yes	No	6	5	1	1
L:L:?1	R:R:L168	3.13	2	Yes	No	0	5	0	1
R:R:C200	R:R:Y196	6.72	2	Yes	Yes	6	6	1	2
R:R:I197	R:R:I201	2.94	0	No	No	6	4	2	1
L:L:?1	R:R:C200	7.18	2	Yes	Yes	0	6	0	1
R:R:F260	R:R:I201	3.77	0	Yes	No	6	4	2	1
L:L:?1	R:R:I201	3.23	2	Yes	No	0	4	0	1
R:R:I203	R:R:I207	2.94	0	No	No	5	7	1	2
L:L:?1	R:R:I203	4.31	2	Yes	No	0	5	0	1
R:R:F204	R:R:W256	8.02	2	No	Yes	7	8	1	1
R:R:F204	R:R:F260	7.5	2	No	Yes	7	6	1	2
L:L:?1	R:R:F204	11.02	2	Yes	No	0	7	0	1
R:R:F252	R:R:W256	8.02	0	No	Yes	9	8	2	1
R:R:N290	R:R:W256	12.43	0	No	Yes	9	8	2	1
L:L:?1	R:R:W256	6.01	2	Yes	Yes	0	8	0	1
R:R:F263	R:R:L259	10.96	2	No	Yes	6	6	1	1
R:R:I284	R:R:L259	4.28	0	No	Yes	5	6	2	1
L:L:?1	R:R:L259	5.22	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:F263	12.86	2	Yes	No	0	6	0	1
R:R:A287	R:R:L259	1.58	0	No	Yes	7	6	2	1
R:R:M118	R:R:S117	1.53	0	Yes	No	6	4	1	2
R:R:F119	R:R:G116	1.51	2	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EW4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.94
Number of Linked Nodes	262
Number of Links	290
Number of Hubs	40
Number of Links mediated by Hubs	154
Number of Communities	10
Number of Nodes involved in Communities	56
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	42198
Length Of Smallest Path	3
Average Path Length	12.2787
Length of Longest Path	29
Minimum Path Strength	1.265
Average Path Strength	5.79324
Maximum Path Strength	15.765
Minimum Path Correlation	0.7
Average Path Correlation	0.920144
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	47.4043
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.0825
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JF9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	JF9
Name	N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
Synonyms
Identifier
Formula	C19 H28 N2 O2
Molecular Weight	316.438
SMILES
PubChem	17253208
Formal Charge	0
Total Atoms	51
Total Chiral Atoms	0
Total Bonds	54
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99500
Sequence	>7EW4_nogp_Chain_R E T L R E H Y Q Y V G K L S T L T T V L F L V I C S F I V L E N L M V L I A I W K N N K F H N R M Y F F I G N L A L C D L L A G I A Y K V N I L M S G K K T F S L S P T V W F L R E G S M F V A L G A S T C S L L A I A I E R H L T M I K M R P Y D A N K R H R V F L L I G M C W L I A F T L G A L P I L G W N C L H N L P D C S T I L P L Y S K K Y I A F C I S I F T A I L V T I V I L Y A R I Y F L V K S S S R K V A N H N N S E R S M A L L R T V V I V V S V F I A C W S P L F I L F L I D V A C R V Q A C P I L F K A Q W F I V L A V L N S A M N P V I Y T L A S K E M R R A F F R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7EW2	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	Fingolimod	-	Gi1/β1/γ2	3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	Fingolimod	-		3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW3	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	Gi1/β1/γ2	3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-		3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW4	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	CYM5541	-	Gi1/β1/γ2	3.2	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	CYM5541	-		3.2	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7C4S	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	-	3.2	2021-06-09	doi.org/10.1126/sciadv.abf5325

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EW4_nogp.zip

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