psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y22	7.99	Yes	Yes	1	0	9
2	L:L:?1	R:R:N95	10.4	Yes	No	1	0	6
3	L:L:?1	R:R:S99	15.93	Yes	Yes	1	0	5
4	L:L:?1	R:R:T103	5.58	Yes	No	1	0	5
5	L:L:?1	R:R:E115	13.05	Yes	Yes	1	0	5
6	L:L:?1	R:R:M118	8.57	Yes	Yes	1	0	6
7	L:L:?1	R:R:F119	10.15	Yes	Yes	1	0	5
8	L:L:?1	R:R:L122	5.24	Yes	No	1	0	6
9	L:L:?1	R:R:G123	3.89	Yes	No	0	0	5
10	L:L:?1	R:R:L189	6.29	Yes	Yes	1	0	5
11	L:L:?1	R:R:W256	5.18	Yes	Yes	1	0	8
12	L:L:?1	R:R:L259	4.19	Yes	No	1	0	6
13	L:L:?1	R:R:F260	6.46	Yes	Yes	1	0	6
14	L:L:?1	R:R:F263	3.69	Yes	Yes	1	0	6
15	L:L:?1	R:R:I284	7.57	Yes	No	0	0	5
16	R:R:L18	R:R:P108	4.93	No	No	0	7	3
17	R:R:F104	R:R:R19	16.03	No	No	0	7	1
18	R:R:H21	R:R:L182	6.43	Yes	No	0	7	3
19	R:R:C185	R:R:H21	4.42	No	Yes	0	9	7
20	R:R:H21	R:R:L191	6.43	Yes	No	0	7	4
21	R:R:T103	R:R:Y22	4.99	No	Yes	1	5	9
22	R:R:F104	R:R:Y22	5.16	No	Yes	0	7	9
23	R:R:W111	R:R:Y22	7.72	Yes	Yes	1	9	9
24	R:R:P190	R:R:Y22	18.08	No	Yes	0	4	9
25	R:R:L182	R:R:Y24	9.38	No	No	0	3	5
26	R:R:T187	R:R:V25	4.76	No	No	0	5	6
27	R:R:P190	R:R:V25	3.53	No	No	0	4	6
28	R:R:K27	R:R:P190	3.35	No	No	0	7	4
29	R:R:F278	R:R:K27	3.72	No	No	0	1	7
30	R:R:L41	R:R:T42	4.42	No	No	0	4	5
31	R:R:F46	R:R:T42	6.49	Yes	No	0	7	5
32	R:R:F46	R:R:Y92	4.13	Yes	Yes	1	7	6
33	R:R:F46	R:R:Q281	7.03	Yes	No	0	7	4
34	R:R:F46	R:R:W282	9.02	Yes	No	0	7	4
35	R:R:F46	R:R:V285	14.42	Yes	No	1	7	4
36	R:R:K93	R:R:L47	7.05	No	No	0	6	5
37	R:R:C50	R:R:Y92	4.03	No	Yes	0	6	6
38	R:R:E56	R:R:F52	7	No	No	0	8	4
39	R:R:D85	R:R:I53	4.2	No	No	0	9	7
40	R:R:E56	R:R:P295	7.86	No	Yes	0	8	9
41	R:R:D85	R:R:N57	16.16	No	No	0	9	9
42	R:R:N57	R:R:P295	4.89	No	Yes	0	9	9
43	R:R:A82	R:R:V60	3.39	No	No	0	9	9
44	R:R:I64	R:R:K69	4.36	No	No	0	8	6
45	R:R:K66	R:R:W65	17.4	No	No	0	5	3
46	R:R:K69	R:R:N67	4.2	No	No	0	6	7
47	R:R:F76	R:R:K69	16.13	No	No	0	4	6
48	R:R:I132	R:R:M74	5.83	No	Yes	0	9	8
49	R:R:E135	R:R:M74	5.41	Yes	Yes	0	9	8
50	R:R:M74	R:R:R136	3.72	Yes	No	0	8	9
51	R:R:F76	R:R:V154	5.24	No	No	0	4	7
52	R:R:F77	R:R:I132	3.77	Yes	No	0	8	9
53	R:R:E135	R:R:F77	7	Yes	Yes	0	9	8
54	R:R:F77	R:R:V154	5.24	Yes	No	0	8	7
55	R:R:F77	R:R:L157	7.31	Yes	No	0	8	6
56	R:R:F77	R:R:I158	3.77	Yes	No	0	8	7
57	R:R:I78	R:R:T299	12.16	No	No	0	8	7
58	R:R:N80	R:R:S128	5.96	No	No	0	9	8
59	R:R:I158	R:R:N80	7.08	No	No	0	7	9
60	R:R:N80	R:R:W162	11.3	No	Yes	0	9	9
61	R:R:L81	R:R:S128	9.01	No	No	0	9	8
62	R:R:L129	R:R:L81	6.92	Yes	No	1	9	9
63	R:R:L81	R:R:N294	8.24	No	Yes	1	9	9
64	R:R:A124	R:R:C84	3.61	No	No	3	8	8
65	R:R:C84	R:R:W162	6.53	No	Yes	3	8	9
66	R:R:D85	R:R:S291	10.31	No	No	0	9	9
67	R:R:L87	R:R:W162	3.42	No	Yes	0	7	9
68	R:R:A91	R:R:S117	3.42	No	No	0	5	4
69	R:R:I96	R:R:Y92	9.67	No	Yes	0	6	6
70	R:R:M118	R:R:Y92	7.18	Yes	Yes	1	6	6
71	R:R:I284	R:R:Y92	3.63	No	Yes	0	5	6
72	R:R:V285	R:R:Y92	3.79	No	Yes	1	4	6
73	R:R:N95	R:R:S99	4.47	No	Yes	1	6	5
74	R:R:M118	R:R:N95	4.21	Yes	No	1	6	6
75	R:R:L97	R:R:M98	5.65	No	Yes	0	5	4
76	R:R:M98	R:R:R114	7.44	Yes	Yes	0	4	6
77	R:R:R114	R:R:S99	6.59	Yes	Yes	1	6	5
78	R:R:R114	R:R:T103	7.76	Yes	No	1	6	5
79	R:R:L106	R:R:V110	5.96	No	No	0	6	6
80	R:R:L106	R:R:R114	6.07	No	Yes	0	6	6
81	R:R:P108	R:R:S107	3.56	No	No	0	3	7
82	R:R:F112	R:R:W111	5.01	Yes	Yes	1	6	9
83	R:R:R114	R:R:W111	7	Yes	Yes	1	6	9
84	R:R:E115	R:R:W111	23.99	Yes	Yes	1	5	9
85	R:R:L191	R:R:W111	11.39	No	Yes	1	4	9
86	R:R:F112	R:R:I173	3.77	Yes	Yes	0	6	5
87	R:R:F112	R:R:N177	10.87	Yes	No	1	6	5
88	R:R:F112	R:R:L179	4.87	Yes	No	1	6	3
89	R:R:F112	R:R:L191	8.53	Yes	No	1	6	4
90	R:R:F112	R:R:Y192	6.19	Yes	Yes	1	6	3
91	R:R:E115	R:R:R114	12.79	Yes	Yes	1	5	6
92	R:R:E115	R:R:L189	3.98	Yes	Yes	1	5	5
93	R:R:F119	R:R:L189	3.65	Yes	Yes	1	5	5
94	R:R:F119	R:R:Y192	7.22	Yes	Yes	1	5	3
95	R:R:F119	R:R:Y196	8.25	Yes	Yes	1	5	6
96	R:R:F166	R:R:V120	3.93	No	No	0	4	5
97	R:R:L122	R:R:W256	5.69	No	Yes	1	6	8
98	R:R:A124	R:R:W162	5.19	No	Yes	3	8	9
99	R:R:T126	R:R:W256	6.06	No	Yes	0	7	8
100	R:R:C127	R:R:C161	3.64	No	No	0	5	7
101	R:R:C127	R:R:I164	3.27	No	No	0	5	3
102	R:R:F252	R:R:L129	4.87	No	Yes	1	9	9
103	R:R:L129	R:R:N294	4.12	Yes	Yes	1	9	9
104	R:R:L129	R:R:Y298	5.86	Yes	Yes	1	9	9
105	R:R:I207	R:R:L130	7.14	No	Yes	0	7	7
106	R:R:L130	R:R:T210	4.42	Yes	No	0	7	6
107	R:R:I211	R:R:L130	4.28	No	Yes	0	8	7
108	R:R:I132	R:R:Y298	7.25	No	Yes	0	9	9
109	R:R:E135	R:R:T139	7.06	Yes	No	0	9	8
110	R:R:E135	R:R:R153	4.65	Yes	No	0	9	5
111	R:R:R136	R:R:Y215	8.23	No	No	0	9	9
112	R:R:R136	R:R:Y298	4.12	No	Yes	0	9	9
113	R:R:H137	R:R:L138	3.86	Yes	No	0	8	5
114	R:R:H137	R:R:I141	13.26	Yes	No	0	8	6
115	R:R:H137	R:R:L214	10.29	Yes	No	0	8	6
116	R:R:L138	R:R:R153	7.29	No	No	0	5	5
117	R:R:K142	R:R:R144	7.43	No	No	0	5	6
118	R:R:D147	R:R:Y146	12.64	No	No	0	3	7
119	R:R:K150	R:R:R153	7.43	No	No	0	7	5
120	R:R:H152	R:R:L156	7.71	No	No	0	4	2
121	R:R:F166	R:R:W162	4.01	No	Yes	0	4	9
122	R:R:L168	R:R:Y196	4.69	No	Yes	0	5	6
123	R:R:L171	R:R:W176	6.83	No	No	0	6	4
124	R:R:P172	R:R:Y192	11.13	No	Yes	1	5	3
125	R:R:P172	R:R:Y196	5.56	No	Yes	1	5	6
126	R:R:W176	R:R:Y196	9.65	No	Yes	0	4	6
127	R:R:F199	R:R:W176	5.01	No	No	0	4	4
128	R:R:L179	R:R:N177	8.24	No	No	1	3	5
129	R:R:C178	R:R:C185	7.28	No	No	0	5	9
130	R:R:I197	R:R:S186	4.64	Yes	No	0	6	5
131	R:R:D266	R:R:T187	5.78	No	No	2	4	5
132	R:R:L277	R:R:T187	7.37	No	No	2	2	5
133	R:R:I188	R:R:L189	7.14	No	Yes	0	4	5
134	R:R:F263	R:R:I188	7.54	Yes	No	0	6	4
135	R:R:L189	R:R:Y192	3.52	Yes	Yes	1	5	3
136	R:R:Y192	R:R:Y196	4.96	Yes	Yes	1	3	6
137	R:R:C200	R:R:Y196	5.38	No	Yes	0	6	6
138	R:R:F263	R:R:I197	12.56	Yes	Yes	0	6	6
139	R:R:A198	R:R:V267	5.09	No	No	0	4	4
140	R:R:F260	R:R:I201	6.28	Yes	Yes	0	6	4
141	R:R:I201	R:R:L264	4.28	Yes	No	0	4	5
142	R:R:F204	R:R:L208	6.09	No	No	0	7	6
143	R:R:F204	R:R:W256	5.01	No	Yes	1	7	8
144	R:R:F204	R:R:F260	24.65	No	Yes	1	7	6
145	R:R:I253	R:R:L208	8.56	No	No	0	6	6
146	R:R:V246	R:R:Y215	3.79	No	No	0	6	9
147	R:R:V249	R:R:Y215	8.83	No	No	0	8	9
148	R:R:F220	R:R:Y219	5.16	No	Yes	0	1	6
149	R:R:M239	R:R:Y219	5.99	Yes	Yes	0	5	6
150	R:R:L242	R:R:Y219	3.52	No	Yes	0	7	6
151	R:R:K223	R:R:M239	8.64	No	Yes	0	5	5
152	R:R:N234	R:R:S226	10.43	No	No	0	4	5
153	R:R:N231	R:R:V229	5.91	No	No	0	5	7
154	R:R:N231	R:R:N233	9.54	No	No	0	5	4
155	R:R:E236	R:R:H232	19.69	No	No	0	4	3
156	R:R:M239	R:R:N234	14.02	Yes	No	0	5	4
157	R:R:I247	R:R:S250	4.64	No	No	0	7	5
158	R:R:I297	R:R:V248	6.14	No	No	0	8	8
159	R:R:F252	R:R:W256	8.02	No	Yes	1	9	8
160	R:R:F252	R:R:N290	10.87	No	No	1	9	9
161	R:R:C255	R:R:L286	6.35	No	No	0	9	7
162	R:R:C255	R:R:N290	4.72	No	No	0	9	9
163	R:R:F260	R:R:W256	5.01	Yes	Yes	1	6	8
164	R:R:N290	R:R:W256	10.17	No	Yes	1	9	8
165	R:R:P258	R:R:S257	3.56	No	No	0	9	5
166	R:R:L286	R:R:P258	4.93	No	No	0	7	9
167	R:R:F263	R:R:L259	8.53	Yes	No	1	6	6
168	R:R:F260	R:R:F263	7.5	Yes	Yes	1	6	6
169	R:R:F283	R:R:L262	8.53	No	No	0	6	5
170	R:R:D266	R:R:L277	10.86	No	No	2	4	2
171	R:R:C269	R:R:C274	7.28	No	Yes	2	4	2
172	R:R:Q272	R:R:V271	4.3	No	No	0	1	1
173	R:R:N294	R:R:P295	3.26	Yes	Yes	0	9	9
174	R:R:N294	R:R:Y298	3.49	Yes	Yes	1	9	9
175	R:R:L300	R:R:V296	4.47	No	No	0	5	6
176	R:R:I297	R:R:Y298	6.04	No	Yes	0	8	9
177	R:R:A133	R:R:I211	3.25	No	No	0	8	8
178	R:R:A280	R:R:I188	3.25	No	No	0	4	4
179	R:R:S51	R:R:V48	3.23	No	No	0	4	4
180	R:R:C50	R:R:K93	3.23	No	No	0	6	6
181	R:R:S107	R:R:V110	3.23	No	No	0	7	6
182	R:R:D184	R:R:P183	3.22	No	No	0	3	4
183	R:R:A148	R:R:K150	3.21	No	No	0	5	7
184	R:R:V248	R:R:V251	3.21	No	No	0	8	6
185	R:R:R243	R:R:Y219	3.09	No	Yes	0	7	6
186	R:R:I297	R:R:V296	3.07	No	No	0	8	6
187	R:R:K102	R:R:S105	3.06	No	No	0	3	3
188	R:R:I173	R:R:T109	3.04	Yes	No	0	5	1
189	R:R:M239	R:R:V222	3.04	Yes	No	0	5	8
190	R:R:L86	R:R:V54	2.98	No	No	0	7	6
191	R:R:L41	R:R:T40	2.95	No	No	0	4	3
192	R:R:L171	R:R:T167	2.95	No	No	0	6	3
193	R:R:L214	R:R:T210	2.95	No	No	0	6	6
194	R:R:I49	R:R:I53	2.94	No	No	0	7	7
195	R:R:D184	R:R:S193	2.94	No	No	0	3	5
196	R:R:I203	R:R:I207	2.94	No	No	0	5	7
197	R:R:I62	R:R:M59	2.92	No	No	0	4	7
198	R:R:I78	R:R:M74	2.92	No	Yes	0	8	8
199	R:R:I164	R:R:M160	2.92	No	No	0	3	3
200	R:R:P145	R:R:R144	2.88	No	No	0	5	6
201	R:R:I49	R:R:L45	2.85	No	No	0	7	4
202	R:R:I49	R:R:L289	2.85	No	No	0	7	5
203	R:R:I173	R:R:L113	2.85	Yes	No	0	5	4
204	R:R:I134	R:R:L130	2.85	No	Yes	0	7	7
205	R:R:I134	R:R:L138	2.85	No	No	0	7	5
206	R:R:I134	R:R:L214	2.85	No	No	0	7	6
207	R:R:I173	R:R:L174	2.85	Yes	No	0	5	4
208	R:R:I261	R:R:L262	2.85	No	No	0	4	5
209	R:R:I265	R:R:L262	2.85	No	No	0	4	5
210	R:R:D266	R:R:I265	2.8	No	No	0	4	4
211	R:R:L61	R:R:L83	2.77	No	No	0	7	6
212	R:R:A131	R:R:F77	2.77	No	Yes	0	7	8
213	R:R:A148	R:R:R144	2.77	No	No	0	5	6
214	R:R:H21	R:R:T17	2.74	Yes	No	0	7	6
215	R:R:H137	R:R:I218	2.65	Yes	No	0	8	8
216	R:R:R227	R:R:S224	2.64	No	No	0	4	4
217	R:R:V288	R:R:Y92	2.52	No	Yes	0	7	6
218	R:R:K223	R:R:R227	2.48	No	No	0	5	4
219	R:R:I62	R:R:W65	2.35	No	No	0	4	3
220	R:R:H137	R:R:R217	2.26	Yes	No	0	8	6
221	R:R:Q23	R:R:Y22	2.25	No	Yes	0	7	9
222	R:R:G169	R:R:P172	2.03	No	No	0	7	5
223	R:R:A82	R:R:G79	1.95	No	No	0	9	6
224	R:R:A88	R:R:G89	1.95	No	No	0	8	7
225	R:R:C274	R:R:P275	1.88	Yes	No	0	2	2
226	R:R:G100	R:R:S99	1.86	No	Yes	0	6	5
227	R:R:G26	R:R:V25	1.84	No	No	0	6	6
228	R:R:A131	R:R:C161	1.81	No	No	0	7	7
229	R:R:A273	R:R:C269	1.81	No	No	2	3	4
230	R:R:A273	R:R:C274	1.81	No	Yes	2	3	2
231	R:R:A121	R:R:A88	1.79	No	No	0	7	8
232	R:R:A124	R:R:A165	1.79	No	No	0	8	8
233	R:R:P295	R:R:V60	1.77	Yes	No	0	9	9
234	R:R:C84	R:R:S125	1.72	No	No	0	8	9
235	R:R:G175	R:R:L174	1.71	No	No	0	5	4
236	R:R:G26	R:R:Q272	1.64	No	No	0	6	1
237	R:R:L182	R:R:P183	1.64	No	No	0	3	4
238	R:R:A292	R:R:I53	1.62	No	No	0	6	7
239	R:R:S238	R:R:V222	1.62	No	No	0	7	8
240	R:R:A91	R:R:M118	1.61	No	Yes	0	5	6
241	R:R:D147	R:R:P145	1.61	No	No	0	3	5
242	R:R:V44	R:R:V48	1.6	No	No	0	5	4
243	R:R:T205	R:R:V209	1.59	No	No	0	3	2
244	R:R:C274	R:R:L277	1.59	Yes	No	2	2	2
245	R:R:A82	R:R:L61	1.58	No	No	0	9	7
246	R:R:A121	R:R:L87	1.58	No	No	0	7	7
247	R:R:A88	R:R:L122	1.58	No	No	0	8	6
248	R:R:A287	R:R:L259	1.58	No	No	0	7	6
249	R:R:T42	R:R:T43	1.57	No	No	0	5	6
250	R:R:I253	R:R:S250	1.55	No	No	0	6	5
251	R:R:I197	R:R:V267	1.54	Yes	No	0	6	4
252	R:R:I201	R:R:V267	1.54	Yes	No	0	4	4
253	R:R:I253	R:R:V212	1.54	No	No	0	6	4
254	R:R:M98	R:R:V94	1.52	Yes	No	0	4	7
255	R:R:I201	R:R:T205	1.52	Yes	No	0	4	3
256	R:R:M140	R:R:T139	1.51	No	No	0	9	8
257	R:R:L221	R:R:V222	1.49	No	No	0	5	8
258	R:R:N233	R:R:S238	1.49	No	No	0	4	7
259	R:R:N234	R:R:S235	1.49	No	No	0	4	4
260	R:R:L241	R:R:V245	1.49	No	No	0	8	8
261	R:R:I265	R:R:I276	1.47	No	No	0	4	4
262	R:R:G116	R:R:Y192	1.45	No	Yes	0	6	3
263	R:R:I197	R:R:K194	1.45	Yes	No	0	6	3
264	R:R:I276	R:R:K279	1.45	No	No	0	4	4
265	R:R:K102	R:R:M98	1.44	No	Yes	0	3	4
266	R:R:I90	R:R:L86	1.43	No	No	0	5	7
267	R:R:I141	R:R:L221	1.43	No	No	0	6	5
268	R:R:I218	R:R:L242	1.43	No	No	0	8	7
269	R:R:L55	R:R:M59	1.41	No	No	0	4	7
270	R:R:A216	R:R:F220	1.39	No	No	0	3	1
271	R:R:L156	R:R:L157	1.38	No	No	0	2	6
272	R:R:A240	R:R:R243	1.38	No	No	0	8	7
273	R:R:A273	R:R:R270	1.38	No	No	0	3	1
274	R:R:D184	R:R:N181	1.35	No	No	0	3	3
275	R:R:A63	R:R:W65	1.3	No	No	0	7	3
276	R:R:H180	R:R:L179	1.29	No	No	0	1	3
277	R:R:I213	R:R:R217	1.25	No	No	0	4	6
278	R:R:N68	R:R:Y75	1.16	No	No	0	6	9
279	R:R:E236	R:R:R237	1.16	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.612	15	1	0
2	R:R:H21	5.005	4	0	7
3	R:R:Y22	7.69833	6	1	9
4	R:R:F46	8.218	5	1	7
5	R:R:M74	4.47	4	0	8
6	R:R:F77	4.97667	6	0	8
7	R:R:Y92	4.99286	7	1	6
8	R:R:M98	4.0125	4	0	4
9	R:R:S99	7.2125	4	1	5
10	R:R:W111	11.022	5	1	9
11	R:R:F112	6.54	6	1	6
12	R:R:R114	7.94167	6	1	6
13	R:R:E115	13.4525	4	1	5
14	R:R:M118	5.3925	4	1	6
15	R:R:F119	7.3175	4	1	5
16	R:R:L129	5.4425	4	1	9
17	R:R:L130	4.6725	4	0	7
18	R:R:E135	6.03	4	0	9
19	R:R:H137	6.464	5	0	8
20	R:R:W162	6.09	5	3	9
21	R:R:I173	3.1275	4	0	5
22	R:R:L189	4.916	5	1	5
23	R:R:Y192	5.745	6	1	3
24	R:R:Y196	6.415	6	1	6
25	R:R:I197	5.0475	4	0	6
26	R:R:I201	3.405	4	0	4
27	R:R:Y219	4.44	4	0	6
28	R:R:M239	7.9225	4	0	5
29	R:R:W256	6.44857	7	1	8
30	R:R:F260	9.98	5	1	6
31	R:R:F263	7.964	5	1	6
32	R:R:C274	3.14	4	2	2
33	R:R:N294	4.7775	4	1	9
34	R:R:P295	4.445	4	0	9
35	R:R:Y298	5.352	5	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L106	R:R:R114	11.6272	6.07	No	Yes	0	6	6
2	L:L:?1	R:R:E115	21.7149	13.05	Yes	Yes	1	0	5
3	L:L:?1	R:R:Y22	31.4117	7.99	Yes	Yes	1	0	9
4	R:R:W111	R:R:Y22	15.7047	7.72	Yes	Yes	1	9	9
5	R:R:L191	R:R:W111	15.5899	11.39	No	Yes	1	4	9
6	R:R:H21	R:R:L191	14.819	6.43	Yes	No	0	7	4
7	R:R:E115	R:R:W111	13.8051	23.99	Yes	Yes	1	5	9
8	R:R:P190	R:R:Y22	17.5778	18.08	No	Yes	0	4	9
9	R:R:P190	R:R:V25	15.1857	3.53	No	No	0	4	6
10	R:R:T187	R:R:V25	11.9343	4.76	No	No	0	5	6
11	L:L:?1	R:R:M118	15.2144	8.57	Yes	Yes	1	0	6
12	R:R:M118	R:R:Y92	13.01	7.18	Yes	Yes	1	6	6
13	R:R:F46	R:R:Y92	12.8443	4.13	Yes	Yes	1	7	6
14	L:L:?1	R:R:I284	13.5843	7.57	Yes	No	0	0	5
15	R:R:I284	R:R:Y92	12.7692	3.63	No	Yes	0	5	6
16	L:L:?1	R:R:W256	92.1278	5.18	Yes	Yes	1	0	8
17	R:R:F252	R:R:W256	97.5129	8.02	No	Yes	1	9	8
18	R:R:F252	R:R:L129	100	4.87	No	Yes	1	9	9
19	R:R:N294	R:R:P295	15.0531	3.26	Yes	Yes	0	9	9
20	R:R:L129	R:R:Y298	90.4513	5.86	Yes	Yes	1	9	9
21	R:R:I132	R:R:Y298	66.1653	7.25	No	Yes	0	9	9
22	R:R:F77	R:R:I132	36.7106	3.77	Yes	No	0	8	9
23	R:R:I132	R:R:M74	29.987	5.83	No	Yes	0	9	8
24	R:R:E135	R:R:M74	57.1533	5.41	Yes	Yes	0	9	8
25	R:R:R136	R:R:Y298	31.8358	4.12	No	Yes	0	9	9
26	R:R:M74	R:R:R136	30.3735	3.72	Yes	No	0	8	9
27	R:R:E135	R:R:F77	31.8667	7	Yes	Yes	0	9	8
28	R:R:M98	R:R:R114	11.6272	7.44	Yes	Yes	0	4	6
29	R:R:F112	R:R:W111	12.8973	5.01	Yes	Yes	1	6	9
30	R:R:F112	R:R:I173	14.1232	3.77	Yes	Yes	0	6	5
31	L:L:?1	R:R:F119	16.3011	10.15	Yes	Yes	1	0	5
32	R:R:F112	R:R:Y192	13.0033	6.19	Yes	Yes	1	6	3
33	L:L:?1	R:R:L189	10.4124	6.29	Yes	Yes	1	0	5
34	R:R:E135	R:R:R153	83.5796	4.65	Yes	No	0	9	5
35	R:R:L138	R:R:R153	71.356	7.29	No	No	0	5	5
36	R:R:I134	R:R:L138	15.7158	2.85	No	No	0	7	5
37	R:R:I134	R:R:L130	10.9116	2.85	No	Yes	0	7	7
38	R:R:H137	R:R:L138	54.8583	3.86	Yes	No	0	8	5
39	R:R:H137	R:R:I141	23.8023	13.26	Yes	No	0	8	6
40	R:R:K150	R:R:R153	12.1993	7.43	No	No	0	7	5
41	R:R:A148	R:R:K150	10.4345	3.21	No	No	0	5	7
42	R:R:H137	R:R:I218	23.789	2.65	Yes	No	0	8	8
43	R:R:I218	R:R:L242	22.3069	1.43	No	No	0	8	7
44	R:R:L242	R:R:Y219	20.8292	3.52	No	Yes	0	7	6
45	R:R:M239	R:R:Y219	12.1949	5.99	Yes	Yes	0	5	6
46	R:R:I141	R:R:L221	22.0705	1.43	No	No	0	6	5
47	R:R:L221	R:R:V222	20.5995	1.49	No	No	0	5	8
48	R:R:M239	R:R:V222	12.2037	3.04	Yes	No	0	5	8
49	R:R:K223	R:R:M239	10.3638	8.64	No	Yes	0	5	5
50	R:R:M239	R:R:N234	10.6134	14.02	Yes	No	0	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y22	7.99	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:N95	10.4	1	Yes	No	0	6	0	1
L:L:?1	R:R:S99	15.93	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:T103	5.58	1	Yes	No	0	5	0	1
L:L:?1	R:R:E115	13.05	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M118	8.57	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F119	10.15	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L122	5.24	1	Yes	No	0	6	0	1
L:L:?1	R:R:G123	3.89	1	Yes	No	0	5	0	1
L:L:?1	R:R:L189	6.29	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W256	5.18	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L259	4.19	1	Yes	No	0	6	0	1
L:L:?1	R:R:F260	6.46	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F263	3.69	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:I284	7.57	1	Yes	No	0	5	0	1
R:R:T103	R:R:Y22	4.99	1	No	Yes	5	9	1	1
R:R:F104	R:R:Y22	5.16	0	No	Yes	7	9	2	1
R:R:W111	R:R:Y22	7.72	1	Yes	Yes	9	9	2	1
R:R:P190	R:R:Y22	18.08	0	No	Yes	4	9	2	1
R:R:M118	R:R:Y92	7.18	1	Yes	Yes	6	6	1	2
R:R:I284	R:R:Y92	3.63	0	No	Yes	5	6	1	2
R:R:N95	R:R:S99	4.47	1	No	Yes	6	5	1	1
R:R:M118	R:R:N95	4.21	1	Yes	No	6	6	1	1
R:R:R114	R:R:S99	6.59	1	Yes	Yes	6	5	2	1
R:R:R114	R:R:T103	7.76	1	Yes	No	6	5	2	1
R:R:R114	R:R:W111	7	1	Yes	Yes	6	9	2	2
R:R:E115	R:R:W111	23.99	1	Yes	Yes	5	9	1	2
R:R:E115	R:R:R114	12.79	1	Yes	Yes	5	6	1	2
R:R:E115	R:R:L189	3.98	1	Yes	Yes	5	5	1	1
R:R:F119	R:R:L189	3.65	1	Yes	Yes	5	5	1	1
R:R:F119	R:R:Y192	7.22	1	Yes	Yes	5	3	1	2
R:R:F119	R:R:Y196	8.25	1	Yes	Yes	5	6	1	2
R:R:L122	R:R:W256	5.69	1	No	Yes	6	8	1	1
R:R:T126	R:R:W256	6.06	0	No	Yes	7	8	2	1
R:R:I188	R:R:L189	7.14	0	No	Yes	4	5	2	1
R:R:F263	R:R:I188	7.54	1	Yes	No	6	4	1	2
R:R:L189	R:R:Y192	3.52	1	Yes	Yes	5	3	1	2
R:R:Y192	R:R:Y196	4.96	1	Yes	Yes	3	6	2	2
R:R:F263	R:R:I197	12.56	1	Yes	Yes	6	6	1	2
R:R:F260	R:R:I201	6.28	1	Yes	Yes	6	4	1	2
R:R:F204	R:R:W256	5.01	1	No	Yes	7	8	2	1
R:R:F204	R:R:F260	24.65	1	No	Yes	7	6	2	1
R:R:F252	R:R:W256	8.02	1	No	Yes	9	8	2	1
R:R:F252	R:R:N290	10.87	1	No	No	9	9	2	2
R:R:F260	R:R:W256	5.01	1	Yes	Yes	6	8	1	1
R:R:N290	R:R:W256	10.17	1	No	Yes	9	8	2	1
R:R:F263	R:R:L259	8.53	1	Yes	No	6	6	1	1
R:R:F260	R:R:F263	7.5	1	Yes	Yes	6	6	1	1
R:R:Q23	R:R:Y22	2.25	0	No	Yes	7	9	2	1
R:R:G100	R:R:S99	1.86	0	No	Yes	6	5	2	1
R:R:A91	R:R:M118	1.61	0	No	Yes	5	6	2	1
R:R:A88	R:R:L122	1.58	0	No	No	8	6	2	1
R:R:A287	R:R:L259	1.58	0	No	No	7	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9WP9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.26
Number of Linked Nodes	249
Number of Links	279
Number of Hubs	35
Number of Links mediated by Hubs	140
Number of Communities	3
Number of Nodes involved in Communities	42
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	51
Number Of Links MetaPath	50
Number of Shortest Paths	73935
Length Of Smallest Path	3
Average Path Length	13.5555
Length of Longest Path	26
Minimum Path Strength	1.46
Average Path Strength	5.97096
Maximum Path Strength	18.52
Minimum Path Correlation	0.7
Average Path Correlation	0.916084
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	41.3941
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.0444
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • regulation of establishment of endothelial barrier • cellular developmental process • regulation of developmental process • endothelium development • negative regulation of biological process • cell development • regulation of cell differentiation • negative regulation of endothelial cell development • epithelial cell differentiation • regulation of cell development • regulation of epithelial cell differentiation • endothelial cell development • multicellular organism development • cell differentiation • regulation of endothelial cell development • anatomical structure development • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of cell differentiation • developmental process • epithelium development • regulation of multicellular organismal development • negative regulation of epithelial cell differentiation • endothelial cell differentiation • regulation of endothelial cell differentiation • negative regulation of developmental process • negative regulation of endothelial cell differentiation • tissue development • negative regulation of cell development • epithelial cell development • establishment of endothelial barrier • negative regulation of establishment of endothelial barrier • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • defense response • response to stress • inflammatory response • regulation of biosynthetic process • regulation of interleukin-1 production • interleukin-1 production • regulation of macromolecule metabolic process • gene expression • regulation of interleukin-1 beta production • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • interleukin-1 beta production • regulation of cytokine production • cytokine production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • cell surface receptor signaling pathway • Notch signaling pathway • anatomical structure morphogenesis • cell periphery • cellular anatomical structure • plasma membrane • membrane • presynapse • synapse • cell junction • intracellular anatomical structure • cytoplasm • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	S1P
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	S1P
Name	(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
Synonyms	sphingosine 1-phosphate
Identifier
Formula	C18 H38 N O5 P
Molecular Weight	379.472
SMILES
PubChem	5283560
Formal Charge	0
Total Atoms	63
Total Chiral Atoms	2
Total Bonds	62
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99500
Sequence	>9WP9_nogp_Chain_R T L R E H Y Q Y V G K T L T T V L F L V I C S F I V L E N L M V L I A I W K N N K M Y F F I G N L A L C D L L A G I A Y K V N I L M S G K K T F S L S P T V W F L R E G S M F V A L G A S T C S L L A I A I E R H L T M I K M R P Y D A N K R H R V F L L I G M C W L I A F T L G A L P I L G W N C L H N L P D C S T I L P L Y S K K Y I A F C I S I F T A I L V T I V I L Y A R I Y F L V K S S S R K V A N H N N S E R S M A L L R T V V I V V S V F I A C W S P L F I L F L I D V A C R V Q A C P I L F K A Q W F I V L A V L N S A M N P V I Y T L A S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7C4S	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	-	3.2	2021-06-09	doi.org/10.1126/sciadv.abf5325
	7EW2	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	FTY720-P	-		3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW3	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	Gi1/β1/γ2	3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-		3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW4	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	CYM-5541	-	Gi1/β1/γ2	3.2	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	CYM-5541	-		3.2	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	9L74	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P d16:1	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.73	2025-11-26	10.1073/pnas.2507421122
	9L74 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P d16:1	-		3.73	2025-11-26	10.1073/pnas.2507421122
	9WP9	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2025-11-26	10.1073/pnas.2507421122
	9WP9 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-		3.25	2025-11-26	10.1073/pnas.2507421122

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9WP9_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.