psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N95	7.42	Yes	No	1	0	6
2	L:L:?1	R:R:S99	16.23	Yes	Yes	1	0	5
3	L:L:?1	R:R:E115	7.16	Yes	Yes	1	0	5
4	L:L:?1	R:R:M118	5.09	Yes	No	1	0	6
5	L:L:?1	R:R:F119	20.85	Yes	Yes	1	0	5
6	L:L:?1	R:R:L122	7.48	Yes	No	0	0	6
7	L:L:?1	R:R:L189	4.99	Yes	Yes	1	0	5
8	L:L:?1	R:R:L259	3.74	Yes	Yes	1	0	6
9	L:L:?1	R:R:F260	5.49	Yes	Yes	1	0	6
10	L:L:?1	R:R:F263	4.39	Yes	Yes	1	0	6
11	L:L:?1	R:R:I284	3.86	Yes	No	1	0	5
12	R:R:E20	R:R:T17	2.82	No	No	0	2	6
13	R:R:H21	R:R:T17	6.85	No	No	0	7	6
14	R:R:L18	R:R:Y22	3.52	No	No	0	7	9
15	R:R:E20	R:R:R19	4.65	No	No	0	2	1
16	R:R:H21	R:R:L179	2.57	No	No	0	7	3
17	R:R:H21	R:R:L191	5.14	No	No	0	7	4
18	R:R:F104	R:R:Y22	3.09	No	No	0	7	9
19	R:R:P190	R:R:Y22	13.91	No	No	0	4	9
20	R:R:L182	R:R:Y24	9.38	No	No	0	3	5
21	R:R:T187	R:R:V25	11.11	No	No	0	5	6
22	R:R:I49	R:R:L45	2.85	No	No	0	7	4
23	R:R:F46	R:R:W282	13.03	No	No	0	7	4
24	R:R:F46	R:R:V285	15.73	No	No	0	7	4
25	R:R:I96	R:R:L47	2.85	No	No	0	6	5
26	R:R:L47	R:R:L97	4.15	No	No	0	5	5
27	R:R:C50	R:R:Y92	2.69	No	Yes	0	6	6
28	R:R:C50	R:R:K93	8.08	No	No	0	6	6
29	R:R:E56	R:R:F52	8.16	No	No	0	8	4
30	R:R:A292	R:R:F52	2.77	No	No	0	6	4
31	R:R:G89	R:R:I53	3.53	No	No	0	7	7
32	R:R:I53	R:R:S291	4.64	No	No	0	7	9
33	R:R:E56	R:R:V296	4.28	No	No	0	8	6
34	R:R:D85	R:R:N57	18.85	No	No	3	9	9
35	R:R:N57	R:R:P295	6.52	No	No	3	9	9
36	R:R:A82	R:R:L61	4.73	No	No	0	9	7
37	R:R:L61	R:R:L83	8.3	No	No	0	7	6
38	R:R:L61	R:R:L86	4.15	No	Yes	0	7	7
39	R:R:I62	R:R:I64	4.42	No	No	0	4	8
40	R:R:I64	R:R:W65	3.52	No	No	0	8	3
41	R:R:K66	R:R:W65	4.64	No	No	0	5	3
42	R:R:K66	R:R:N68	5.6	No	No	0	5	6
43	R:R:N68	R:R:Y75	20.93	No	No	0	6	9
44	R:R:H71	R:R:M74	5.25	No	Yes	0	8	8
45	R:R:H71	R:R:Y75	10.89	No	No	0	8	9
46	R:R:E135	R:R:R73	4.65	No	Yes	0	9	5
47	R:R:K150	R:R:R73	6.19	Yes	Yes	0	7	5
48	R:R:R73	R:R:V154	3.92	Yes	No	0	5	7
49	R:R:I78	R:R:M74	2.92	No	Yes	0	8	8
50	R:R:E135	R:R:M74	6.77	No	Yes	0	9	8
51	R:R:M74	R:R:R136	7.44	Yes	No	0	8	9
52	R:R:S302	R:R:Y75	2.54	No	No	0	8	9
53	R:R:F76	R:R:F77	12.86	Yes	Yes	4	4	8
54	R:R:F76	R:R:V154	6.55	Yes	No	4	4	7
55	R:R:F76	R:R:I158	6.28	Yes	Yes	0	4	7
56	R:R:A131	R:R:F77	2.77	No	Yes	0	7	8
57	R:R:E135	R:R:F77	8.16	No	Yes	0	9	8
58	R:R:F77	R:R:V154	5.24	Yes	No	4	8	7
59	R:R:F77	R:R:L157	2.44	Yes	No	0	8	6
60	R:R:I78	R:R:T299	3.04	No	No	0	8	7
61	R:R:C84	R:R:N80	4.72	No	Yes	2	8	9
62	R:R:N80	R:R:S128	4.47	Yes	No	2	9	8
63	R:R:I158	R:R:N80	9.91	Yes	Yes	0	7	9
64	R:R:C161	R:R:N80	4.72	Yes	Yes	2	7	9
65	R:R:N80	R:R:W162	7.91	Yes	Yes	2	9	9
66	R:R:L81	R:R:P295	3.28	No	No	0	9	9
67	R:R:A124	R:R:C84	3.61	No	No	2	8	8
68	R:R:C84	R:R:W162	7.84	No	Yes	2	8	9
69	R:R:D85	R:R:S291	8.83	No	No	0	9	9
70	R:R:D85	R:R:P295	4.83	No	No	3	9	9
71	R:R:I96	R:R:Y92	15.71	No	Yes	0	6	6
72	R:R:V285	R:R:Y92	5.05	No	Yes	0	4	6
73	R:R:V288	R:R:Y92	15.14	No	Yes	0	7	6
74	R:R:N95	R:R:R114	9.64	No	Yes	1	6	6
75	R:R:M118	R:R:N95	2.8	No	No	1	6	6
76	R:R:L106	R:R:M98	8.48	No	No	0	6	4
77	R:R:M98	R:R:R114	8.69	No	Yes	0	4	6
78	R:R:S99	R:R:T103	3.2	Yes	No	1	5	5
79	R:R:R114	R:R:S99	6.59	Yes	Yes	1	6	5
80	R:R:R114	R:R:T103	3.88	Yes	No	1	6	5
81	R:R:L106	R:R:V110	10.43	No	No	0	6	6
82	R:R:S107	R:R:T109	3.2	No	No	5	7	1
83	R:R:S107	R:R:V110	3.23	No	No	5	7	6
84	R:R:T109	R:R:V110	3.17	No	No	5	1	6
85	R:R:F112	R:R:W111	13.03	No	Yes	1	6	9
86	R:R:R114	R:R:W111	4	Yes	Yes	1	6	9
87	R:R:E115	R:R:W111	26.17	Yes	Yes	1	5	9
88	R:R:P190	R:R:W111	5.4	No	Yes	0	4	9
89	R:R:L191	R:R:W111	11.39	No	Yes	1	4	9
90	R:R:F112	R:R:I173	3.77	No	No	0	6	5
91	R:R:F112	R:R:L191	2.44	No	No	1	6	4
92	R:R:E115	R:R:R114	4.65	Yes	Yes	1	5	6
93	R:R:E115	R:R:L189	3.98	Yes	Yes	1	5	5
94	R:R:F119	R:R:L189	2.44	Yes	Yes	1	5	5
95	R:R:F119	R:R:Y192	4.13	Yes	Yes	1	5	3
96	R:R:L122	R:R:W256	5.69	No	Yes	0	6	8
97	R:R:A124	R:R:W162	3.89	No	Yes	2	8	9
98	R:R:T126	R:R:W256	8.49	No	Yes	0	7	8
99	R:R:C161	R:R:S128	3.44	Yes	No	2	7	8
100	R:R:F252	R:R:L129	2.44	No	No	0	9	9
101	R:R:L129	R:R:N294	2.75	No	No	0	9	9
102	R:R:L129	R:R:Y298	3.52	No	Yes	0	9	9
103	R:R:I207	R:R:L130	4.28	No	No	0	7	7
104	R:R:L130	R:R:T210	2.95	No	No	0	7	6
105	R:R:I132	R:R:R136	2.51	No	No	0	9	9
106	R:R:I132	R:R:Y298	2.42	No	Yes	0	9	9
107	R:R:A133	R:R:I211	3.25	No	No	7	8	8
108	R:R:A133	R:R:Y215	4	No	Yes	7	8	9
109	R:R:I134	R:R:L214	2.85	No	No	0	7	6
110	R:R:R136	R:R:Y215	10.29	No	Yes	0	9	9
111	R:R:H137	R:R:L214	5.14	No	No	0	8	6
112	R:R:H137	R:R:R217	12.41	No	No	0	8	6
113	R:R:K150	R:R:L138	2.82	Yes	No	0	7	5
114	R:R:K142	R:R:R144	6.19	No	No	0	5	6
115	R:R:P145	R:R:R144	2.88	No	No	0	5	6
116	R:R:D147	R:R:Y146	10.34	No	No	0	3	7
117	R:R:K150	R:R:R153	4.95	Yes	No	0	7	5
118	R:R:H152	R:R:R151	7.9	No	No	0	4	2
119	R:R:F155	R:R:I158	3.77	No	Yes	0	1	7
120	R:R:L156	R:R:M160	5.65	No	No	0	2	3
121	R:R:L163	R:R:M160	4.24	No	No	0	3	3
122	R:R:C161	R:R:W162	3.92	Yes	Yes	2	7	9
123	R:R:L168	R:R:Y196	8.21	No	Yes	0	5	6
124	R:R:F199	R:R:L168	2.44	No	No	0	4	5
125	R:R:L171	R:R:P172	3.28	No	Yes	0	6	5
126	R:R:L171	R:R:W176	3.42	No	Yes	0	6	4
127	R:R:P172	R:R:Y192	8.34	Yes	Yes	1	5	3
128	R:R:P172	R:R:Y196	11.13	Yes	Yes	1	5	6
129	R:R:I173	R:R:L174	2.85	No	No	0	5	4
130	R:R:G175	R:R:W176	2.81	No	Yes	0	5	4
131	R:R:G175	R:R:N177	5.09	No	No	0	5	5
132	R:R:S193	R:R:W176	2.47	No	Yes	0	5	4
133	R:R:K195	R:R:W176	5.8	No	Yes	0	4	4
134	R:R:L179	R:R:N177	8.24	No	No	0	3	5
135	R:R:C178	R:R:D184	3.11	No	No	0	5	3
136	R:R:C178	R:R:C185	7.28	No	No	0	5	9
137	R:R:H180	R:R:L179	2.57	No	No	0	1	3
138	R:R:N181	R:R:P183	4.89	No	No	0	3	4
139	R:R:D184	R:R:K194	5.53	No	No	0	3	3
140	R:R:I188	R:R:S186	3.1	Yes	No	0	4	5
141	R:R:K194	R:R:S186	6.12	No	No	0	3	5
142	R:R:L277	R:R:T187	8.84	No	No	0	2	5
143	R:R:F278	R:R:T187	2.59	No	No	0	1	5
144	R:R:I188	R:R:L189	4.28	Yes	Yes	0	4	5
145	R:R:F263	R:R:I188	6.28	Yes	Yes	0	6	4
146	R:R:D266	R:R:I188	9.8	Yes	Yes	0	4	4
147	R:R:L189	R:R:Y192	16.41	Yes	Yes	1	5	3
148	R:R:Y192	R:R:Y196	8.94	Yes	Yes	1	3	6
149	R:R:C200	R:R:Y196	9.41	No	Yes	0	6	6
150	R:R:F263	R:R:I197	3.77	Yes	No	0	6	6
151	R:R:I197	R:R:V267	6.14	No	No	0	6	4
152	R:R:F199	R:R:I203	2.51	No	No	0	4	5
153	R:R:F260	R:R:I201	3.77	Yes	No	0	6	4
154	R:R:F204	R:R:W256	4.01	No	Yes	0	7	8
155	R:R:F204	R:R:F260	34.29	No	Yes	0	7	6
156	R:R:L208	R:R:V212	2.98	No	No	0	6	4
157	R:R:F252	R:R:L208	3.65	No	No	0	9	6
158	R:R:I253	R:R:L208	8.56	No	No	0	6	6
159	R:R:L214	R:R:T210	2.95	No	No	0	6	6
160	R:R:I211	R:R:Y215	4.84	No	Yes	7	8	9
161	R:R:V246	R:R:Y215	2.52	No	Yes	0	6	9
162	R:R:V249	R:R:Y215	3.79	No	Yes	0	8	9
163	R:R:K223	R:R:Y219	5.97	No	Yes	8	5	6
164	R:R:M239	R:R:Y219	3.59	No	Yes	8	5	6
165	R:R:L242	R:R:Y219	5.86	No	Yes	0	7	6
166	R:R:L242	R:R:V222	4.47	No	No	0	7	8
167	R:R:K223	R:R:M239	8.64	No	No	8	5	5
168	R:R:N234	R:R:S226	5.96	No	No	0	4	5
169	R:R:N231	R:R:N233	2.72	No	No	0	5	4
170	R:R:N234	R:R:S235	2.98	No	No	0	4	4
171	R:R:L241	R:R:R237	4.86	No	No	0	8	4
172	R:R:L242	R:R:V246	2.98	No	No	0	7	6
173	R:R:I247	R:R:S250	3.1	No	No	0	7	5
174	R:R:I297	R:R:V248	4.61	No	No	6	8	8
175	R:R:V248	R:R:Y298	3.79	No	Yes	6	8	9
176	R:R:F252	R:R:W256	9.02	No	Yes	0	9	8
177	R:R:C255	R:R:N290	6.3	No	No	0	9	9
178	R:R:N290	R:R:W256	16.95	No	Yes	0	9	8
179	R:R:P258	R:R:S257	3.56	No	No	0	9	5
180	R:R:F260	R:R:L259	4.87	Yes	Yes	1	6	6
181	R:R:F263	R:R:L259	8.53	Yes	Yes	1	6	6
182	R:R:I284	R:R:L259	2.85	No	Yes	1	5	6
183	R:R:D266	R:R:L262	10.86	Yes	No	0	4	5
184	R:R:F283	R:R:L262	4.87	No	No	0	6	5
185	R:R:D266	R:R:I265	2.8	Yes	No	0	4	4
186	R:R:I265	R:R:I276	2.94	No	No	0	4	4
187	R:R:D266	R:R:L277	8.14	Yes	No	0	4	2
188	R:R:C269	R:R:C274	7.28	No	Yes	0	4	2
189	R:R:C274	R:R:I276	3.27	Yes	No	0	2	4
190	R:R:C274	R:R:L277	6.35	Yes	No	0	2	2
191	R:R:Q281	R:R:W282	10.95	No	No	0	4	4
192	R:R:L286	R:R:L289	4.15	No	No	0	7	5
193	R:R:N290	R:R:N294	5.45	No	No	0	9	9
194	R:R:L300	R:R:V296	4.47	No	No	0	5	6
195	R:R:I297	R:R:Y298	6.04	No	Yes	6	8	9
196	R:R:M118	R:R:Y92	2.39	No	Yes	0	6	6
197	R:R:L81	R:R:Y298	2.34	No	Yes	0	9	9
198	R:R:L87	R:R:W162	2.28	No	Yes	0	7	9
199	R:R:F70	R:R:H71	2.26	No	No	0	8	8
200	R:R:F220	R:R:Y219	2.06	No	Yes	0	1	6
201	R:R:G169	R:R:P172	2.03	No	Yes	0	7	5
202	R:R:A82	R:R:G79	1.95	No	No	0	9	6
203	R:R:A88	R:R:G89	1.95	No	No	0	8	7
204	R:R:A165	R:R:G123	1.95	No	No	0	8	5
205	R:R:C274	R:R:P275	1.88	Yes	No	0	2	2
206	R:R:G100	R:R:S99	1.86	No	Yes	0	6	5
207	R:R:G26	R:R:V25	1.84	No	No	0	6	6
208	R:R:G169	R:R:V120	1.84	No	No	0	7	5
209	R:R:C127	R:R:C161	1.82	No	Yes	0	5	7
210	R:R:A121	R:R:A88	1.79	No	No	0	7	8
211	R:R:A121	R:R:A91	1.79	No	No	0	7	5
212	R:R:A124	R:R:A165	1.79	No	No	0	8	8
213	R:R:P108	R:R:S107	1.78	No	No	0	3	7
214	R:R:G159	R:R:I158	1.76	No	Yes	0	3	7
215	R:R:A91	R:R:S117	1.71	No	No	0	5	4
216	R:R:K279	R:R:P275	1.67	No	No	0	4	2
217	R:R:G26	R:R:Q272	1.64	No	No	0	6	1
218	R:R:C127	R:R:I164	1.64	No	No	0	5	3
219	R:R:L182	R:R:P183	1.64	No	No	0	3	4
220	R:R:L286	R:R:P258	1.64	No	No	0	7	9
221	R:R:A292	R:R:I53	1.62	No	No	0	6	7
222	R:R:A280	R:R:I188	1.62	No	Yes	0	4	4
223	R:R:S238	R:R:V222	1.62	No	No	0	7	8
224	R:R:V44	R:R:V48	1.6	No	No	0	5	4
225	R:R:V248	R:R:V251	1.6	No	No	0	8	6
226	R:R:T43	R:R:V44	1.59	No	No	0	6	5
227	R:R:T205	R:R:V209	1.59	No	No	0	3	2
228	R:R:T210	R:R:V209	1.59	No	No	0	6	2
229	R:R:T244	R:R:V245	1.59	No	No	0	9	8
230	R:R:A287	R:R:L259	1.58	No	Yes	0	7	6
231	R:R:A292	R:R:L289	1.58	No	No	0	6	5
232	R:R:I261	R:R:S257	1.55	No	No	0	4	5
233	R:R:I49	R:R:V285	1.54	No	No	0	7	4
234	R:R:I49	R:R:V288	1.54	No	No	0	7	7
235	R:R:I218	R:R:V222	1.54	No	No	0	8	8
236	R:R:I164	R:R:T167	1.52	No	No	0	3	3
237	R:R:M293	R:R:V251	1.52	No	No	0	7	6
238	R:R:A273	R:R:Q272	1.52	No	No	0	3	1
239	R:R:F119	R:R:G116	1.51	Yes	No	0	5	6
240	R:R:L86	R:R:V54	1.49	Yes	No	0	7	6
241	R:R:N231	R:R:S226	1.49	No	No	0	5	5
242	R:R:N234	R:R:S238	1.49	No	No	0	4	7
243	R:R:I203	R:R:I207	1.47	No	No	0	5	7
244	R:R:I141	R:R:K142	1.45	No	No	0	6	5
245	R:R:K142	R:R:K150	1.44	No	Yes	0	5	7
246	R:R:I201	R:R:L264	1.43	No	No	0	4	5
247	R:R:L55	R:R:M59	1.41	No	No	0	4	7
248	R:R:K69	R:R:N72	1.4	No	No	0	6	7
249	R:R:L58	R:R:L86	1.38	No	Yes	0	4	7
250	R:R:L86	R:R:N57	1.37	Yes	No	0	7	9
251	R:R:N67	R:R:N68	1.36	No	No	0	7	6
252	R:R:R73	R:R:T139	1.29	Yes	No	0	5	8
253	R:R:H232	R:R:N233	1.28	No	No	0	3	4
254	R:R:I213	R:R:R217	1.25	No	No	0	4	6
255	R:R:F104	R:R:K101	1.24	No	No	0	7	2
256	R:R:S125	R:R:W256	1.24	No	Yes	0	9	8
257	R:R:K228	R:R:R227	1.24	No	No	0	5	4
258	R:R:F76	R:R:N72	1.21	Yes	No	0	4	7
259	R:R:N149	R:R:R151	1.21	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.88182	11	1	0
2	R:R:R73	4.0125	4	0	5
3	R:R:M74	5.595	4	0	8
4	R:R:F76	6.725	4	4	4
5	R:R:F77	6.294	5	4	8
6	R:R:N80	6.346	5	2	9
7	R:R:L86	2.0975	4	0	7
8	R:R:Y92	8.196	5	0	6
9	R:R:S99	6.97	4	1	5
10	R:R:W111	11.998	5	1	9
11	R:R:R114	6.24167	6	1	6
12	R:R:E115	10.49	4	1	5
13	R:R:F119	7.2325	4	1	5
14	R:R:K150	3.85	4	0	7
15	R:R:I158	5.43	4	0	7
16	R:R:C161	3.475	4	2	7
17	R:R:W162	5.168	5	2	9
18	R:R:P172	6.195	4	1	5
19	R:R:W176	3.625	4	0	4
20	R:R:I188	5.016	5	0	4
21	R:R:L189	6.42	5	1	5
22	R:R:Y192	9.455	4	1	3
23	R:R:Y196	9.4225	4	1	6
24	R:R:Y215	5.088	5	7	9
25	R:R:Y219	4.37	4	8	6
26	R:R:W256	7.56667	6	0	8
27	R:R:L259	4.314	5	1	6
28	R:R:F260	12.105	4	1	6
29	R:R:F263	5.7425	4	1	6
30	R:R:D266	7.9	4	0	4
31	R:R:C274	4.695	4	0	2
32	R:R:Y298	3.622	5	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E115	18.4944	7.16	Yes	Yes	1	0	5
2	R:R:E115	R:R:W111	16.9716	26.17	Yes	Yes	1	5	9
3	L:L:?1	R:R:L189	36.6014	4.99	Yes	Yes	1	0	5
4	R:R:I188	R:R:L189	24.5103	4.28	Yes	Yes	0	4	5
5	R:R:D266	R:R:I188	30.3864	9.8	Yes	Yes	0	4	4
6	R:R:D266	R:R:L277	21.1042	8.14	Yes	No	0	4	2
7	R:R:L277	R:R:T187	11.7144	8.84	No	No	0	2	5
8	L:L:?1	R:R:F263	20.9374	4.39	Yes	Yes	1	0	6
9	R:R:F263	R:R:I188	18.9841	6.28	Yes	Yes	0	6	4
10	L:L:?1	R:R:M118	20.9105	5.09	Yes	No	1	0	6
11	R:R:M118	R:R:Y92	21.8683	2.39	No	Yes	0	6	6
12	L:L:?1	R:R:L122	100	7.48	Yes	No	0	0	6
13	R:R:L122	R:R:W256	99.8278	5.69	No	Yes	0	6	8
14	R:R:F252	R:R:W256	99.8009	9.02	No	Yes	0	9	8
15	R:R:F252	R:R:L129	98.2942	2.44	No	No	0	9	9
16	R:R:L129	R:R:Y298	99.5372	3.52	No	Yes	0	9	9
17	R:R:L81	R:R:Y298	38.5654	2.34	No	Yes	0	9	9
18	R:R:L81	R:R:P295	37.3332	3.28	No	No	0	9	9
19	R:R:D85	R:R:P295	24.9839	4.83	No	No	3	9	9
20	R:R:D85	R:R:S291	24.4189	8.83	No	No	0	9	9
21	R:R:I53	R:R:S291	23.0682	4.64	No	No	0	7	9
22	R:R:A292	R:R:I53	14.7385	1.62	No	No	0	6	7
23	R:R:N57	R:R:P295	11.1009	6.52	No	No	3	9	9
24	R:R:L86	R:R:N57	10.4283	1.37	Yes	No	0	7	9
25	R:R:I132	R:R:Y298	79.7837	2.42	No	Yes	0	9	9
26	R:R:I132	R:R:R136	79.0034	2.51	No	No	0	9	9
27	R:R:M74	R:R:R136	61.2516	7.44	Yes	No	0	8	9
28	R:R:H71	R:R:M74	14.6739	5.25	No	Yes	0	8	8
29	R:R:H71	R:R:Y75	11.8112	10.89	No	No	0	8	9
30	R:R:E135	R:R:M74	47.4333	6.77	No	Yes	0	9	8
31	R:R:E135	R:R:R73	13.135	4.65	No	Yes	0	9	5
32	R:R:E135	R:R:F77	33.3782	8.16	No	Yes	0	9	8
33	R:R:F76	R:R:F77	28.4707	12.86	Yes	Yes	4	4	8
34	R:R:F76	R:R:I158	25.6565	6.28	Yes	Yes	0	4	7
35	R:R:I158	R:R:N80	21.6261	9.91	Yes	Yes	0	7	9
36	R:R:M98	R:R:R114	15.2658	8.69	No	Yes	0	4	6
37	R:R:L106	R:R:M98	12.7475	8.48	No	No	0	6	4
38	R:R:L106	R:R:V110	10.2185	10.43	No	No	0	6	6
39	L:L:?1	R:R:F119	20.4961	20.85	Yes	Yes	1	0	5
40	R:R:F119	R:R:Y192	18.8388	4.13	Yes	Yes	1	5	3
41	R:R:Y192	R:R:Y196	27.4914	8.94	Yes	Yes	1	3	6
42	R:R:L168	R:R:Y196	24.8924	8.21	No	Yes	0	5	6
43	R:R:F199	R:R:L168	23.1705	2.44	No	No	0	4	5
44	R:R:F199	R:R:I203	21.3033	2.51	No	No	0	4	5
45	R:R:I203	R:R:I207	19.4199	1.47	No	No	0	5	7
46	R:R:L189	R:R:Y192	24.6771	16.41	Yes	Yes	1	5	3
47	R:R:I207	R:R:L130	17.5258	4.28	No	No	0	7	7
48	R:R:L130	R:R:T210	15.621	2.95	No	No	0	7	6
49	R:R:R136	R:R:Y215	26.6466	10.29	No	Yes	0	9	9
50	R:R:K150	R:R:R73	10.2077	6.19	Yes	Yes	0	7	5
51	R:R:P172	R:R:Y192	14.5071	8.34	Yes	Yes	1	5	3
52	R:R:V246	R:R:Y215	21.3033	2.52	No	Yes	0	6	9
53	R:R:L242	R:R:V246	19.9204	2.98	No	No	0	7	6
54	R:R:L242	R:R:V222	13.1619	4.47	No	No	0	7	8
55	R:R:S238	R:R:V222	10.4176	1.62	No	No	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:N95	7.42	1	Yes	No	0	6	0	1
L:L:?1	R:R:S99	16.23	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:E115	7.16	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M118	5.09	1	Yes	No	0	6	0	1
L:L:?1	R:R:F119	20.85	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L122	7.48	1	Yes	No	0	6	0	1
L:L:?1	R:R:L189	4.99	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L259	3.74	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F260	5.49	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F263	4.39	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:I284	3.86	1	Yes	No	0	5	0	1
R:R:N95	R:R:R114	9.64	1	No	Yes	6	6	1	2
R:R:M118	R:R:N95	2.8	1	No	No	6	6	1	1
R:R:S99	R:R:T103	3.2	1	Yes	No	5	5	1	2
R:R:R114	R:R:S99	6.59	1	Yes	Yes	6	5	2	1
R:R:R114	R:R:T103	3.88	1	Yes	No	6	5	2	2
R:R:R114	R:R:W111	4	1	Yes	Yes	6	9	2	2
R:R:E115	R:R:W111	26.17	1	Yes	Yes	5	9	1	2
R:R:E115	R:R:R114	4.65	1	Yes	Yes	5	6	1	2
R:R:E115	R:R:L189	3.98	1	Yes	Yes	5	5	1	1
R:R:F119	R:R:L189	2.44	1	Yes	Yes	5	5	1	1
R:R:F119	R:R:Y192	4.13	1	Yes	Yes	5	3	1	2
R:R:L122	R:R:W256	5.69	0	No	Yes	6	8	1	2
R:R:I188	R:R:L189	4.28	0	Yes	Yes	4	5	2	1
R:R:F263	R:R:I188	6.28	1	Yes	Yes	6	4	1	2
R:R:L189	R:R:Y192	16.41	1	Yes	Yes	5	3	1	2
R:R:F263	R:R:I197	3.77	1	Yes	No	6	6	1	2
R:R:F260	R:R:I201	3.77	1	Yes	No	6	4	1	2
R:R:F204	R:R:W256	4.01	0	No	Yes	7	8	2	2
R:R:F204	R:R:F260	34.29	0	No	Yes	7	6	2	1
R:R:F260	R:R:L259	4.87	1	Yes	Yes	6	6	1	1
R:R:F263	R:R:L259	8.53	1	Yes	Yes	6	6	1	1
R:R:I284	R:R:L259	2.85	1	No	Yes	5	6	1	1
R:R:M118	R:R:Y92	2.39	1	No	Yes	6	6	1	2
R:R:G100	R:R:S99	1.86	0	No	Yes	6	5	2	1
R:R:A287	R:R:L259	1.58	0	No	Yes	7	6	2	1
R:R:F119	R:R:G116	1.51	1	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9L74_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.42
Number of Linked Nodes	240
Number of Links	259
Number of Hubs	32
Number of Links mediated by Hubs	119
Number of Communities	8
Number of Nodes involved in Communities	43
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	33048
Length Of Smallest Path	3
Average Path Length	13.9687
Length of Longest Path	31
Minimum Path Strength	1.305
Average Path Strength	6.04122
Maximum Path Strength	20.21
Minimum Path Correlation	0.7
Average Path Correlation	0.925535
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	47.2068
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.16
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • regulation of establishment of endothelial barrier • cellular developmental process • regulation of developmental process • endothelium development • negative regulation of biological process • cell development • regulation of cell differentiation • negative regulation of endothelial cell development • epithelial cell differentiation • regulation of cell development • regulation of epithelial cell differentiation • endothelial cell development • multicellular organism development • cell differentiation • regulation of endothelial cell development • anatomical structure development • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of cell differentiation • developmental process • epithelium development • regulation of multicellular organismal development • negative regulation of epithelial cell differentiation • endothelial cell differentiation • regulation of endothelial cell differentiation • negative regulation of developmental process • negative regulation of endothelial cell differentiation • tissue development • negative regulation of cell development • epithelial cell development • establishment of endothelial barrier • negative regulation of establishment of endothelial barrier • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • defense response • response to stress • inflammatory response • regulation of biosynthetic process • regulation of interleukin-1 production • interleukin-1 production • regulation of macromolecule metabolic process • gene expression • regulation of interleukin-1 beta production • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • interleukin-1 beta production • regulation of cytokine production • cytokine production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • cell surface receptor signaling pathway • Notch signaling pathway • anatomical structure morphogenesis • cell periphery • cellular anatomical structure • plasma membrane • membrane • presynapse • synapse • cell junction • intracellular anatomical structure • cytoplasm • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99500
Sequence	>9L74_nogp_Chain_R T L R E H Y Q Y V G T V L F L V I C S F I V L E N L M V L I A I W K N N K F H N R M Y F F I G N L A L C D L L A G I A Y K V N I L M S G K K T F S L S P T V W F L R E G S M F V A L G A S T C S L L A I A I E R H L T M I K M R P Y D A N K R H R V F L L I G M C W L I A F T L G A L P I L G W N C L H N L P D C S T I L P L Y S K K Y I A F C I S I F T A I L V T I V I L Y A R I Y F L V K S S S R K V A N H N N S E R S M A L L R T V V I V V S V F I A C W S P L F I L F L I D V A C V Q A C P I L F K A Q W F I V L A V L N S A M N P V I Y T L A S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7C4S	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	-	3.2	2021-06-09	doi.org/10.1126/sciadv.abf5325
	7EW2	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	FTY720-P	-		3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW3	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	Gi1/β1/γ2	3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-		3.1	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW4	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	CYM-5541	-	Gi1/β1/γ2	3.2	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	7EW4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	CYM-5541	-		3.2	2021-09-29	doi.org/10.1038/s41422-021-00567-w
	9L74	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P d16:1	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.73	2025-11-26	10.1073/pnas.2507421122
	9L74 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P d16:1	-		3.73	2025-11-26	10.1073/pnas.2507421122
	9WP9	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2025-11-26	10.1073/pnas.2507421122
	9WP9 (No Gprot)	A	Lipid	Lysophospholipid	S1P₃	Homo sapiens	S1P	-		3.25	2025-11-26	10.1073/pnas.2507421122

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9L74_nogp.zip

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