psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:D16	A:A:S13	4.42	No	No	0	4	7
2	A:A:E21	A:A:K17	4.05	No	No	0	3	4
3	A:A:D27	A:A:S23	4.42	No	No	0	6	7
4	A:A:S23	B:B:N88	7.45	No	Yes	0	7	7
5	A:A:K28	A:A:M25	5.76	No	No	0	4	4
6	A:A:I26	B:B:K89	7.27	No	Yes	0	9	9
7	A:A:D27	B:B:K89	11.06	No	Yes	0	6	9
8	A:A:K28	A:A:N29	4.2	No	No	0	4	4
9	A:A:L30	B:B:K78	5.64	No	No	0	5	8
10	A:A:D33	A:A:E32	9.09	No	No	0	5	3
11	A:A:E32	A:A:K36	4.05	No	No	0	3	1
12	A:A:D33	B:B:K78	8.3	No	No	0	5	8
13	A:A:E35	A:A:R39	4.65	No	No	0	4	5
14	A:A:K36	A:A:R39	3.71	No	No	0	1	5
15	A:A:R38	R:R:S59	3.95	No	No	0	4	7
16	A:A:H220	A:A:T40	4.11	No	No	0	7	7
17	A:A:F219	A:A:L41	8.53	Yes	No	0	8	6
18	A:A:L41	A:A:T242	7.37	No	No	0	6	8
19	A:A:I383	A:A:L41	4.28	No	No	0	8	6
20	A:A:D240	A:A:R42	3.57	No	No	0	6	9
21	A:A:R42	A:A:V241	3.92	No	No	0	9	9
22	A:A:F219	A:A:L43	3.65	Yes	No	0	8	7
23	A:A:I245	A:A:L43	5.71	Yes	No	0	7	7
24	A:A:L44	A:A:L46	11.07	No	No	19	9	8
25	A:A:F238	A:A:L44	14.61	Yes	No	0	9	9
26	A:A:I244	A:A:L44	4.28	Yes	No	19	8	9
27	A:A:D223	A:A:L45	6.79	No	No	0	9	8
28	A:A:I244	A:A:L46	4.28	Yes	No	19	8	8
29	A:A:I276	A:A:L46	4.28	No	No	0	8	8
30	A:A:G47	A:A:K53	3.49	No	No	0	9	9
31	A:A:D49	A:A:N50	4.04	No	No	0	8	9
32	A:A:K53	A:A:S51	4.59	No	No	0	9	9
33	A:A:K53	A:A:V247	4.55	No	No	0	9	7
34	A:A:I56	A:A:V247	9.22	No	No	5	7	7
35	A:A:F290	A:A:I56	3.77	Yes	No	5	9	7
36	A:A:I56	A:A:N292	5.66	No	No	5	7	9
37	A:A:F212	A:A:V57	3.93	No	No	0	9	7
38	A:A:G206	B:B:N119	6.79	No	No	0	8	9
39	A:A:I207	A:A:V224	4.61	Yes	No	0	9	9
40	A:A:I207	B:B:W99	4.7	Yes	Yes	20	9	9
41	A:A:I207	B:B:L117	5.71	Yes	No	20	9	9
42	A:A:I207	B:B:D118	4.2	Yes	No	0	9	9
43	A:A:F208	A:A:T210	3.89	No	No	0	5	7
44	A:A:D223	A:A:F208	11.94	No	No	0	9	5
45	A:A:E209	A:A:F222	9.33	No	No	0	9	7
46	A:A:E209	B:B:R96	5.82	No	No	0	9	6
47	A:A:M221	A:A:T210	4.52	No	No	0	8	7
48	A:A:K211	A:A:N218	4.2	No	No	0	4	4
49	A:A:H220	A:A:K211	9.17	No	No	0	7	4
50	A:A:F212	A:A:F219	10.72	No	Yes	0	9	8
51	A:A:F212	A:A:M221	6.22	No	No	0	9	8
52	A:A:N218	A:A:Q213	9.24	No	No	0	4	3
53	A:A:D215	A:A:V214	4.38	Yes	No	10	5	6
54	A:A:R373	A:A:V214	3.92	No	No	10	5	6
55	A:A:F376	A:A:V214	6.55	Yes	No	10	8	6
56	A:A:D215	A:A:R373	11.91	Yes	No	10	5	5
57	A:A:D215	A:A:F376	11.94	Yes	Yes	10	5	8
58	A:A:D215	R:R:R133	3.57	Yes	No	0	5	5
59	A:A:F219	A:A:V217	5.24	Yes	No	0	8	5
60	A:A:V217	R:R:L132	4.47	No	Yes	0	5	7
61	A:A:C379	A:A:F219	6.98	No	Yes	0	8	8
62	A:A:F222	A:A:H220	7.92	No	No	0	7	7
63	A:A:F222	B:B:W99	16.04	No	Yes	0	7	9
64	A:A:V224	A:A:W234	17.16	No	Yes	0	9	9
65	A:A:R231	A:A:W234	4	No	Yes	0	9	9
66	A:A:D272	A:A:R231	8.34	No	No	0	8	9
67	A:A:R232	B:B:D228	3.57	No	Yes	0	8	9
68	A:A:K233	B:B:Y145	3.58	Yes	Yes	3	9	8
69	A:A:K233	B:B:M188	5.76	Yes	No	3	9	8
70	A:A:K233	B:B:D228	6.91	Yes	Yes	0	9	9
71	A:A:K233	B:B:N230	4.2	Yes	No	0	9	9
72	A:A:I235	A:A:W234	3.52	No	Yes	0	9	9
73	A:A:F238	A:A:W234	5.01	Yes	Yes	0	9	9
74	A:A:W234	B:B:Y145	4.82	Yes	Yes	0	9	8
75	A:A:I235	A:A:N279	4.25	No	No	0	9	8
76	A:A:Q236	A:A:W281	14.24	No	No	0	8	5
77	A:A:Q236	B:B:R314	4.67	No	Yes	0	8	8
78	A:A:C237	B:B:Y59	5.38	No	Yes	0	8	8
79	A:A:C237	B:B:W99	5.22	No	Yes	0	8	9
80	A:A:F238	A:A:V241	5.24	Yes	No	0	9	9
81	A:A:F238	B:B:W99	12.03	Yes	Yes	0	9	9
82	A:A:N239	B:B:W332	6.78	No	Yes	0	8	9
83	A:A:D240	B:B:K57	5.53	No	Yes	0	6	9
84	A:A:I244	A:A:L282	4.28	Yes	No	0	8	9
85	A:A:I244	A:A:I285	4.42	Yes	No	0	8	7
86	A:A:F290	A:A:I245	3.77	Yes	Yes	5	9	7
87	A:A:I245	A:A:I375	4.42	Yes	No	5	7	9
88	A:A:D272	A:A:F246	7.17	No	No	0	8	9
89	A:A:F246	A:A:F273	6.43	No	Yes	0	9	9
90	A:A:F246	A:A:I276	3.77	No	No	0	9	8
91	A:A:N292	A:A:V247	4.43	No	No	5	9	7
92	A:A:F345	A:A:V248	6.55	Yes	No	0	8	7
93	A:A:D249	A:A:S251	10.31	No	No	0	8	9
94	A:A:D249	A:A:D252	3.99	No	No	0	8	8
95	A:A:D249	A:A:K293	11.06	No	No	0	8	9
96	A:A:L297	A:A:S250	4.5	No	No	0	8	6
97	A:A:L296	A:A:S251	4.5	No	No	0	6	9
98	A:A:D252	A:A:N264	5.39	No	No	21	8	9
99	A:A:D252	A:A:R265	4.76	No	Yes	21	8	9
100	A:A:L297	A:A:Y253	3.52	No	Yes	0	8	8
101	A:A:K300	A:A:Y253	11.94	No	Yes	0	9	8
102	A:A:I308	A:A:Y253	8.46	Yes	Yes	0	7	8
103	A:A:Y253	A:A:Y311	10.92	Yes	No	0	8	6
104	A:A:N264	A:A:R265	4.82	No	Yes	21	9	9
105	A:A:N264	A:A:Y311	4.65	No	No	0	9	6
106	A:A:E268	A:A:R265	6.98	No	Yes	0	9	9
107	A:A:F312	A:A:L266	7.31	Yes	No	0	8	8
108	A:A:L270	A:A:Q267	5.32	No	No	0	6	4
109	A:A:N271	A:A:Q267	6.6	No	No	0	5	4
110	A:A:E344	A:A:L270	3.98	No	No	0	5	6
111	A:A:I348	A:A:L270	8.56	No	No	0	4	6
112	A:A:F273	A:A:W277	4.01	Yes	Yes	6	9	6
113	A:A:F273	A:A:V287	5.24	Yes	No	6	9	6
114	A:A:F273	A:A:F345	7.5	Yes	Yes	6	9	8
115	A:A:C359	A:A:F273	4.19	No	Yes	0	5	9
116	A:A:I348	A:A:K274	7.27	No	No	0	4	5
117	A:A:V287	A:A:W277	3.68	No	Yes	6	6	6
118	A:A:S349	A:A:W277	13.59	No	Yes	0	7	6
119	A:A:H357	A:A:W277	25.39	No	Yes	0	7	6
120	A:A:L282	A:A:N279	12.36	No	No	0	9	8
121	A:A:W281	B:B:W332	3.75	No	Yes	0	5	9
122	A:A:I382	A:A:S286	6.19	No	No	0	6	8
123	A:A:D378	A:A:I288	20.99	No	Yes	0	7	9
124	A:A:L289	A:A:L291	6.92	No	No	6	9	8
125	A:A:F345	A:A:L289	7.31	Yes	No	6	8	9
126	A:A:C359	A:A:L289	4.76	No	No	0	5	9
127	A:A:F290	A:A:T364	9.08	Yes	No	5	9	9
128	A:A:F290	A:A:N371	9.67	Yes	No	5	9	9
129	A:A:F290	A:A:I375	5.02	Yes	No	5	9	9
130	A:A:F345	A:A:L291	3.65	Yes	No	6	8	8
131	A:A:F363	A:A:L291	8.53	Yes	No	6	5	8
132	A:A:K293	A:A:N292	6.99	No	No	0	9	9
133	A:A:K338	A:A:Q294	9.49	No	No	6	5	6
134	A:A:F363	A:A:Q294	11.71	Yes	No	6	5	6
135	A:A:D295	A:A:L296	5.43	No	No	0	9	6
136	A:A:C365	A:A:D295	4.67	No	No	0	8	9
137	A:A:V301	A:A:V334	4.81	No	No	0	7	4
138	A:A:D331	A:A:L302	6.79	No	No	0	4	2
139	A:A:A303	A:A:K305	4.82	No	No	0	5	3
140	A:A:E309	A:A:K307	18.9	No	No	0	4	6
141	A:A:F312	A:A:I308	3.77	Yes	Yes	0	8	7
142	A:A:F315	A:A:I308	15.07	Yes	Yes	0	6	7
143	A:A:F312	A:A:F340	7.5	Yes	No	0	8	7
144	A:A:E314	A:A:P313	9.43	No	No	0	6	6
145	A:A:F315	A:A:R336	7.48	Yes	No	0	6	5
146	A:A:F315	A:A:F340	11.79	Yes	No	0	6	7
147	A:A:Y318	A:A:Y339	3.97	No	Yes	0	6	3
148	A:A:F340	A:A:Y318	13.41	No	No	0	7	6
149	A:A:K343	A:A:Y318	4.78	No	No	0	3	6
150	A:A:P321	A:A:T320	3.5	No	No	23	5	1
151	A:A:T320	A:A:Y339	3.75	No	Yes	23	1	3
152	A:A:P321	A:A:Y339	6.95	No	Yes	23	5	3
153	A:A:R333	A:A:R336	9.6	No	No	0	5	5
154	A:A:T335	A:A:Y339	3.75	No	Yes	0	4	3
155	A:A:F363	A:A:K338	19.85	Yes	No	6	5	5
156	A:A:R342	A:A:Y339	7.2	No	Yes	0	4	3
157	A:A:P361	A:A:R342	7.21	No	No	0	5	4
158	A:A:F363	A:A:R342	6.41	Yes	No	0	5	4
159	A:A:D347	A:A:K343	4.15	No	No	0	4	3
160	A:A:R356	A:A:R389	6.4	No	No	0	2	5
161	A:A:I358	A:A:Y360	6.04	No	No	0	4	8
162	A:A:C359	A:A:P361	3.77	No	No	0	5	5
163	A:A:D378	A:A:Y360	13.79	No	No	22	7	8
164	A:A:I382	A:A:Y360	7.25	No	No	22	6	8
165	A:A:H362	A:A:R374	11.28	No	No	0	9	4
166	A:A:D368	A:A:T364	7.23	No	No	5	9	9
167	A:A:N371	A:A:T364	13.16	No	No	5	9	9
168	A:A:D368	A:A:E370	7.8	No	No	0	9	4
169	A:A:D368	A:A:N371	13.46	No	No	5	9	9
170	A:A:N377	A:A:R373	7.23	No	No	0	4	5
171	A:A:F376	A:A:N377	4.83	Yes	No	0	8	4
172	A:A:F376	A:A:K380	7.44	Yes	No	10	8	7
173	A:A:F376	R:R:L132	8.53	Yes	Yes	10	8	7
174	A:A:D378	A:A:I382	4.2	No	No	22	7	6
175	A:A:K380	R:R:L132	5.64	No	Yes	10	7	7
176	A:A:D381	A:A:Q385	3.92	No	No	14	8	5
177	A:A:D381	R:R:E214	12.99	No	Yes	14	8	7
178	A:A:L384	R:R:P131	6.57	No	No	0	6	8
179	A:A:L384	R:R:R213	3.64	No	No	14	6	5
180	A:A:L384	R:R:E214	9.28	No	Yes	14	6	7
181	A:A:Q385	R:R:E214	11.47	No	Yes	14	5	7
182	A:A:E390	R:R:H56	7.39	No	No	0	4	6
183	A:A:Y391	R:R:R124	12.35	No	Yes	0	4	9
184	A:A:L393	R:R:A270	4.73	No	No	0	8	8
185	B:B:D5	B:B:Q9	6.53	No	No	0	1	3
186	B:B:E12	B:B:R8	4.65	No	No	0	4	3
187	B:B:E12	B:B:Q9	7.65	No	No	0	4	3
188	B:B:K15	G:G:L19	14.1	No	No	0	6	9
189	B:B:N16	B:B:R19	6.03	No	No	0	1	4
190	B:B:I18	G:G:E22	6.83	No	No	0	7	9
191	B:B:D258	B:B:R22	14.29	Yes	No	2	7	6
192	B:B:R22	G:G:R27	11.73	No	Yes	2	6	8
193	B:B:C25	G:G:R27	15.32	No	Yes	0	3	8
194	B:B:A26	B:B:Q259	4.55	No	Yes	0	3	6
195	B:B:D27	G:G:K29	5.53	No	No	0	8	4
196	B:B:D27	G:G:S31	7.36	No	No	0	8	9
197	B:B:A28	B:B:Q32	4.55	No	No	0	4	1
198	B:B:L261	B:B:L30	4.15	No	No	0	5	5
199	B:B:L30	B:B:M262	7.07	No	No	0	5	4
200	B:B:I33	B:B:Q32	5.49	No	No	0	3	1
201	B:B:I33	G:G:A34	4.87	No	No	0	3	6
202	B:B:L300	B:B:T34	8.84	No	No	0	6	5
203	B:B:T34	G:G:M38	6.02	No	No	0	5	4
204	B:B:I37	B:B:R283	8.77	Yes	Yes	9	2	9
205	B:B:I37	G:G:M38	5.83	Yes	No	0	2	4
206	B:B:I37	G:G:E42	6.83	Yes	No	9	2	1
207	B:B:D38	B:B:P39	9.66	No	No	0	1	1
208	B:B:R283	B:B:V40	6.54	Yes	Yes	9	9	3
209	B:B:D298	B:B:V40	10.22	Yes	Yes	9	9	3
210	B:B:V40	G:G:L51	4.47	Yes	No	0	3	6
211	B:B:M45	B:B:W339	3.49	No	Yes	0	4	9
212	B:B:M45	B:B:N340	5.61	No	Yes	0	4	9
213	B:B:M45	G:G:L50	5.65	No	No	0	4	9
214	B:B:R46	B:B:R48	8.53	No	No	0	5	7
215	B:B:K337	B:B:T47	7.51	Yes	No	13	6	3
216	B:B:T47	B:B:W339	7.28	No	Yes	13	3	9
217	B:B:N340	B:B:R48	7.23	Yes	No	0	9	7
218	B:B:R49	B:B:T87	5.17	Yes	No	0	7	5
219	B:B:I338	B:B:R49	5.01	No	Yes	12	5	7
220	B:B:R49	G:G:F61	7.48	Yes	Yes	12	7	8
221	B:B:R49	G:G:R62	12.79	Yes	No	0	7	7
222	B:B:R52	B:B:T50	6.47	No	No	0	7	3
223	B:B:K337	B:B:T50	6.01	Yes	No	0	6	3
224	B:B:L51	B:B:W82	19.36	No	Yes	7	9	9
225	B:B:L336	B:B:L51	6.92	No	No	7	7	9
226	B:B:F335	B:B:R52	12.83	No	No	0	4	7
227	B:B:G53	B:B:K89	3.49	No	Yes	0	9	9
228	B:B:H54	B:B:I58	11.93	Yes	No	0	9	9
229	B:B:H54	B:B:S74	9.76	Yes	No	0	9	9
230	B:B:H54	B:B:I80	13.26	Yes	No	7	9	8
231	B:B:H54	B:B:W82	4.23	Yes	Yes	7	9	9
232	B:B:L55	R:R:H58	3.86	No	No	0	6	8
233	B:B:A56	B:B:Q75	6.06	No	No	0	7	9
234	B:B:A56	B:B:D76	6.18	No	No	0	7	9
235	B:B:K57	B:B:Y59	4.78	Yes	Yes	8	9	8
236	B:B:K57	B:B:Q75	18.98	Yes	No	8	9	9
237	B:B:K57	B:B:W332	11.6	Yes	Yes	8	9	9
238	B:B:Q75	B:B:Y59	7.89	No	Yes	8	9	8
239	B:B:W332	B:B:Y59	5.79	Yes	Yes	8	9	8
240	B:B:A60	B:B:C103	3.61	No	No	0	7	8
241	B:B:M61	B:B:S72	4.6	Yes	No	0	6	9
242	B:B:C317	B:B:M61	6.48	No	Yes	0	7	6
243	B:B:G319	B:B:M61	3.49	No	Yes	0	5	6
244	B:B:A328	B:B:M61	4.83	No	Yes	0	5	6
245	B:B:H62	B:B:Y105	4.36	No	Yes	0	6	6
246	B:B:H62	B:B:R150	11.28	No	Yes	0	6	6
247	B:B:L70	B:B:W63	7.97	No	Yes	0	5	7
248	B:B:S84	B:B:W63	4.94	No	Yes	0	5	7
249	B:B:T321	B:B:W63	10.92	No	Yes	0	7	7
250	B:B:A328	B:B:W63	5.19	No	Yes	0	5	7
251	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
252	B:B:D66	B:B:R68	4.76	No	Yes	0	8	5
253	B:B:S67	B:B:T321	7.99	No	No	26	5	7
254	B:B:D322	B:B:S67	4.42	No	No	0	1	5
255	B:B:D323	B:B:S67	10.31	No	No	26	7	5
256	B:B:L69	B:B:R68	4.86	No	Yes	0	5	5
257	B:B:D83	B:B:R68	7.15	No	Yes	12	8	5
258	B:B:R68	B:B:Y85	9.26	Yes	Yes	12	5	4
259	B:B:L69	B:B:Y105	7.03	No	Yes	0	5	6
260	B:B:L70	B:B:W82	5.69	No	Yes	0	5	9
261	B:B:L79	B:B:V71	4.47	No	No	0	7	8
262	B:B:S72	B:B:W82	3.71	No	Yes	7	9	9
263	B:B:L336	B:B:S72	6.01	No	No	7	7	9
264	B:B:D76	B:B:S74	8.83	No	No	0	9	9
265	B:B:D76	B:B:K78	8.3	No	No	0	9	8
266	B:B:G77	B:B:L95	5.13	No	Yes	0	8	8
267	B:B:G77	B:B:S98	3.71	No	No	0	8	8
268	B:B:I93	B:B:L79	5.71	Yes	No	0	7	7
269	B:B:L79	B:B:L95	4.15	No	Yes	0	7	8
270	B:B:I80	B:B:W82	12.92	No	Yes	7	8	9
271	B:B:I80	B:B:K89	5.82	No	Yes	7	8	9
272	B:B:H91	B:B:I81	6.63	No	No	0	5	7
273	B:B:I81	B:B:L126	4.28	No	Yes	0	7	5
274	B:B:K89	B:B:W82	15.08	Yes	Yes	7	9	9
275	B:B:L336	B:B:W82	4.56	No	Yes	7	7	9
276	B:B:D83	B:B:Y85	4.6	No	Yes	12	8	4
277	B:B:D83	B:B:T86	7.23	No	No	0	8	6
278	B:B:S84	G:G:F61	5.28	No	Yes	0	5	8
279	B:B:Y85	G:G:P60	8.34	Yes	No	0	4	9
280	B:B:Y85	G:G:F61	6.19	Yes	Yes	12	4	8
281	B:B:N88	B:B:T86	10.24	Yes	No	0	7	6
282	B:B:H91	B:B:V90	5.54	No	No	0	5	5
283	B:B:H91	B:B:V133	8.3	No	Yes	0	5	4
284	B:B:I93	B:B:Y124	4.84	Yes	Yes	11	7	6
285	B:B:I93	B:B:V133	12.29	Yes	Yes	11	7	4
286	B:B:L95	B:B:V100	4.47	Yes	No	0	8	9
287	B:B:L95	B:B:Y124	5.86	Yes	Yes	0	8	6
288	B:B:S97	B:B:W99	3.71	No	Yes	0	8	9
289	B:B:D118	B:B:S97	8.83	No	No	0	9	8
290	B:B:L117	B:B:W99	5.69	No	Yes	20	9	9
291	B:B:M101	B:B:Y145	5.99	No	Yes	0	9	8
292	B:B:C149	B:B:T102	6.76	No	No	0	8	8
293	B:B:V112	B:B:Y105	5.05	No	Yes	11	8	6
294	B:B:L126	B:B:Y105	3.52	Yes	Yes	11	5	6
295	B:B:A106	B:B:F151	8.32	No	Yes	0	6	9
296	B:B:F151	B:B:P107	4.33	Yes	No	0	9	6
297	B:B:N110	B:B:S108	8.94	No	No	0	4	6
298	B:B:D154	B:B:S108	8.83	No	No	0	6	6
299	B:B:N110	B:B:Y111	3.49	No	Yes	0	4	4
300	B:B:K127	B:B:N110	9.79	No	No	0	4	4
301	B:B:I123	B:B:Y111	3.63	Yes	Yes	0	6	4
302	B:B:N125	B:B:Y111	12.79	No	Yes	0	4	4
303	B:B:S136	B:B:Y111	5.09	No	Yes	0	4	4
304	B:B:D154	B:B:Y111	6.9	No	Yes	0	6	4
305	B:B:V112	B:B:Y124	3.79	No	Yes	11	8	6
306	B:B:L126	B:B:V112	5.96	Yes	No	11	5	8
307	B:B:A113	B:B:F151	4.16	No	Yes	0	9	9
308	B:B:C114	B:B:Y124	5.38	No	Yes	0	8	6
309	B:B:G144	B:B:N119	5.09	No	No	0	8	9
310	B:B:C121	B:B:L139	6.35	No	No	0	8	9
311	B:B:S122	B:B:Y124	5.09	No	Yes	0	8	6
312	B:B:F151	B:B:I123	5.02	Yes	Yes	3	9	6
313	B:B:I123	B:B:I157	4.42	Yes	Yes	3	6	7
314	B:B:I123	B:B:I171	5.89	Yes	Yes	3	6	6
315	B:B:V133	B:B:Y124	3.79	Yes	Yes	11	4	6
316	B:B:V135	B:B:Y124	5.05	No	Yes	0	4	6
317	B:B:N125	B:B:T128	5.85	No	No	0	4	3
318	B:B:L126	B:B:V133	4.47	Yes	Yes	11	5	4
319	B:B:R134	B:B:T128	3.88	No	No	0	3	3
320	B:B:E130	B:B:N132	9.2	No	No	0	3	3
321	B:B:G174	B:B:R137	6	No	No	0	4	5
322	B:B:L139	B:B:W169	22.78	No	Yes	0	9	8
323	B:B:H142	B:B:L146	6.43	Yes	No	3	9	7
324	B:B:H142	B:B:T159	6.85	Yes	Yes	3	9	9
325	B:B:H142	B:B:S161	12.55	Yes	Yes	3	9	9
326	B:B:D163	B:B:H142	6.3	Yes	Yes	3	9	9
327	B:B:H142	B:B:W169	9.52	Yes	Yes	3	9	8
328	B:B:H142	B:B:Q176	6.18	Yes	Yes	3	9	4
329	B:B:D163	B:B:T143	7.23	Yes	No	0	9	5
330	B:B:G162	B:B:Y145	5.79	No	Yes	3	9	8
331	B:B:D186	B:B:Y145	12.64	No	Yes	3	9	8
332	B:B:M188	B:B:Y145	3.59	No	Yes	3	8	8
333	B:B:L146	B:B:T159	4.42	No	Yes	3	7	9
334	B:B:C148	B:B:R150	4.18	No	Yes	0	6	6
335	B:B:L190	B:B:R150	3.64	No	Yes	0	5	6
336	B:B:L192	B:B:R150	3.64	No	Yes	0	5	6
337	B:B:F151	B:B:I157	5.02	Yes	Yes	3	9	7
338	B:B:F151	B:B:I171	3.77	Yes	Yes	3	9	6
339	B:B:L152	B:B:Q156	3.99	No	No	0	3	5
340	B:B:L152	B:B:L192	6.92	No	No	0	3	5
341	B:B:D153	B:B:Q156	6.53	No	No	0	5	5
342	B:B:E172	B:B:N155	15.77	No	No	0	6	3
343	B:B:L168	B:B:Q156	5.32	Yes	No	0	6	5
344	B:B:I157	B:B:W169	3.52	Yes	Yes	3	7	8
345	B:B:I157	B:B:I171	4.42	Yes	Yes	3	7	6
346	B:B:L190	B:B:V158	7.45	No	No	0	5	5
347	B:B:F199	B:B:V158	7.87	Yes	No	0	9	5
348	B:B:T159	B:B:W169	12.13	Yes	Yes	3	9	8
349	B:B:S160	B:B:V187	4.85	No	No	0	6	9
350	B:B:L190	B:B:S160	9.01	No	No	0	5	6
351	B:B:G162	B:B:S161	3.71	No	Yes	3	9	9
352	B:B:D163	B:B:S161	8.83	Yes	Yes	3	9	9
353	B:B:D186	B:B:G162	6.71	No	No	3	9	9
354	B:B:D163	B:B:T165	11.56	Yes	No	0	9	7
355	B:B:T165	B:B:T181	4.71	No	No	0	7	2
356	B:B:C166	B:B:F180	4.19	No	Yes	0	8	7
357	B:B:C166	B:B:V187	5.12	No	No	0	8	9
358	B:B:A167	B:B:W169	5.19	No	Yes	3	4	8
359	B:B:A167	B:B:Q176	6.06	No	Yes	3	4	4
360	B:B:L168	B:B:T177	4.42	Yes	No	4	6	4
361	B:B:L168	B:B:T178	4.42	Yes	No	4	6	4
362	B:B:L168	B:B:V213	4.47	Yes	No	0	6	4
363	B:B:Q176	B:B:W169	14.24	Yes	Yes	3	4	8
364	B:B:D170	B:B:E172	10.39	No	No	0	9	6
365	B:B:D170	B:B:T173	10.12	No	No	4	9	5
366	B:B:D170	B:B:Q175	3.92	No	No	4	9	4
367	B:B:Q175	B:B:T173	8.5	No	No	4	4	5
368	B:B:Q175	B:B:T177	4.25	No	No	4	4	4
369	B:B:Q176	B:B:T179	7.09	Yes	No	0	4	4
370	B:B:T177	B:B:T178	4.71	No	No	4	4	4
371	B:B:F180	B:B:T178	7.78	Yes	No	4	7	4
372	B:B:F180	B:B:F199	11.79	Yes	Yes	4	7	9
373	B:B:F180	B:B:W211	15.03	Yes	Yes	4	7	8
374	B:B:F180	B:B:G216	4.52	Yes	No	0	7	4
375	B:B:H183	B:B:V187	9.69	Yes	No	0	9	9
376	B:B:A203	B:B:H183	8.78	No	Yes	0	8	9
377	B:B:H183	B:B:K209	14.41	Yes	Yes	4	9	6
378	B:B:H183	B:B:W211	4.23	Yes	Yes	4	9	8
379	B:B:D205	B:B:T184	8.67	No	No	0	9	3
380	B:B:C204	B:B:M188	4.86	No	No	0	7	8
381	B:B:I232	B:B:S189	4.64	Yes	No	0	8	7
382	B:B:F234	B:B:S191	5.28	Yes	No	0	5	8
383	B:B:F199	B:B:L192	3.65	Yes	No	0	9	5
384	B:B:A193	B:B:F234	8.32	No	Yes	0	4	5
385	B:B:G238	B:B:P194	4.06	No	No	0	7	4
386	B:B:L198	B:B:L210	5.54	No	No	0	3	5
387	B:B:D212	B:B:L198	4.07	Yes	No	0	9	3
388	B:B:F199	B:B:S201	3.96	Yes	No	4	9	9
389	B:B:F199	B:B:W211	14.03	Yes	Yes	4	9	8
390	B:B:I232	B:B:V200	6.14	Yes	No	2	8	6
391	B:B:F234	B:B:V200	7.87	Yes	No	0	5	6
392	B:B:F241	B:B:V200	6.55	Yes	No	2	6	6
393	B:B:S201	B:B:W211	4.94	No	Yes	4	9	8
394	B:B:G202	B:B:I229	3.53	No	Yes	0	6	7
395	B:B:A203	B:B:D205	4.63	No	No	0	8	9
396	B:B:C204	B:B:D228	10.89	No	Yes	0	7	9
397	B:B:D205	B:B:S207	5.89	No	No	0	9	5
398	B:B:K209	B:B:S207	4.59	Yes	No	0	6	5
399	B:B:K209	B:B:W211	9.28	Yes	Yes	4	6	8
400	B:B:C218	B:B:K209	4.85	No	Yes	4	5	6
401	B:B:K209	B:B:T221	12.01	Yes	No	0	6	7
402	B:B:L210	B:B:Q220	6.65	No	Yes	0	5	7
403	B:B:L210	B:B:L255	6.92	No	No	0	5	6
404	B:B:C218	B:B:W211	5.22	No	Yes	4	5	8
405	B:B:D212	B:B:R214	8.34	Yes	No	16	9	9
406	B:B:D212	B:B:E215	10.39	Yes	No	16	9	3
407	B:B:D212	B:B:R219	14.29	Yes	No	16	9	5
408	B:B:E215	B:B:R214	16.28	No	No	16	3	9
409	B:B:E215	B:B:R219	5.82	No	No	16	3	5
410	B:B:M217	G:G:M21	4.33	No	No	0	3	1
411	B:B:F222	B:B:Q220	7.03	Yes	Yes	2	8	7
412	B:B:D258	B:B:Q220	16.97	Yes	Yes	2	7	7
413	B:B:F222	B:B:F241	11.79	Yes	Yes	2	8	6
414	B:B:F222	B:B:F253	12.86	Yes	Yes	2	8	6
415	B:B:D258	B:B:F222	9.55	Yes	Yes	2	7	8
416	B:B:G224	B:B:R251	6	No	Yes	0	6	8
417	B:B:H225	B:B:I229	7.95	Yes	Yes	2	9	7
418	B:B:H225	B:B:T243	8.21	Yes	Yes	2	9	8
419	B:B:H225	B:B:S245	16.74	Yes	No	2	9	9
420	B:B:D247	B:B:H225	5.04	Yes	Yes	2	9	9
421	B:B:H225	B:B:R251	32.72	Yes	Yes	2	9	8
422	B:B:F253	B:B:H225	4.53	Yes	Yes	2	6	9
423	B:B:D247	B:B:E226	7.8	Yes	No	0	9	3
424	B:B:D228	B:B:S227	5.89	Yes	No	0	9	6
425	B:B:D246	B:B:S227	5.89	No	No	0	9	6
426	B:B:I229	B:B:T243	4.56	Yes	Yes	2	7	8
427	B:B:I229	B:B:S245	7.74	Yes	No	2	7	9
428	B:B:F241	B:B:I232	5.02	Yes	Yes	2	6	8
429	B:B:I232	B:B:T243	6.08	Yes	Yes	2	8	8
430	B:B:C233	B:B:F278	4.19	No	Yes	0	3	7
431	B:B:F234	B:B:L255	4.87	Yes	No	0	5	6
432	B:B:F235	B:B:P236	13	Yes	Yes	17	6	7
433	B:B:F235	B:B:F278	9.65	Yes	Yes	17	6	7
434	B:B:F235	G:G:L37	7.31	Yes	No	0	6	7
435	B:B:F235	G:G:Y40	5.16	Yes	Yes	17	6	6
436	B:B:F278	B:B:P236	5.78	Yes	Yes	17	7	7
437	B:B:G282	B:B:P236	4.06	No	Yes	0	9	7
438	B:B:P236	G:G:Y40	4.17	Yes	Yes	17	7	6
439	B:B:N237	B:B:N239	6.81	No	No	0	5	2
440	B:B:N237	G:G:Y40	15.12	No	Yes	0	5	6
441	B:B:N239	B:B:R256	9.64	No	No	0	2	9
442	B:B:A240	G:G:L37	4.73	No	No	0	6	7
443	B:B:F241	B:B:F253	11.79	Yes	Yes	2	6	6
444	B:B:F253	B:B:T243	7.78	Yes	Yes	2	6	8
445	B:B:G244	B:B:I273	3.53	No	No	0	5	6
446	B:B:D247	B:B:S245	4.42	Yes	No	2	9	9
447	B:B:D247	B:B:T249	14.45	Yes	No	0	9	6
448	B:B:S265	B:B:T249	6.4	No	No	0	2	6
449	B:B:C250	B:B:Y264	4.03	No	Yes	0	8	5
450	B:B:C250	B:B:I273	4.91	No	No	0	8	6
451	B:B:F253	B:B:R251	25.66	Yes	Yes	2	6	8
452	B:B:E260	B:B:R251	25.59	No	Yes	2	6	8
453	B:B:L252	B:B:Y264	8.21	No	Yes	0	7	5
454	B:B:E260	B:B:F253	10.49	No	Yes	2	6	6
455	B:B:A257	B:B:D254	4.63	No	No	0	7	9
456	B:B:D254	B:B:L261	6.79	No	No	0	9	5
457	B:B:D254	G:G:A33	6.18	No	No	0	9	7
458	B:B:L255	B:B:R256	4.86	No	No	0	6	9
459	B:B:R256	G:G:I28	11.27	No	No	0	9	4
460	B:B:D258	G:G:R27	3.57	Yes	Yes	2	7	8
461	B:B:L261	B:B:Q259	3.99	No	Yes	0	5	6
462	B:B:Q259	G:G:R27	15.19	Yes	Yes	0	6	8
463	B:B:Q259	G:G:V30	7.16	Yes	No	0	6	8
464	B:B:E260	B:B:T263	7.06	No	No	0	6	1
465	B:B:M262	B:B:Y264	14.37	No	Yes	0	4	5
466	B:B:A302	B:B:M262	4.83	No	No	0	2	4
467	B:B:L285	B:B:Y264	4.69	Yes	Yes	0	6	5
468	B:B:W297	B:B:Y264	9.65	Yes	Yes	0	8	5
469	B:B:H266	B:B:N268	3.83	No	No	0	4	4
470	B:B:H266	B:B:R304	12.41	No	No	0	4	5
471	B:B:I269	B:B:Y289	3.63	No	Yes	0	4	7
472	B:B:C271	B:B:Y289	4.03	No	Yes	0	5	7
473	B:B:C271	B:B:D290	4.67	No	Yes	0	5	6
474	B:B:C271	B:B:D291	7.78	No	No	0	5	8
475	B:B:D290	B:B:G272	5.03	Yes	No	0	6	4
476	B:B:I273	B:B:Y289	10.88	No	Yes	0	6	7
477	B:B:D290	B:B:T274	4.34	Yes	No	8	6	8
478	B:B:R314	B:B:T274	7.76	Yes	No	8	8	8
479	B:B:L318	B:B:S275	6.01	No	No	0	6	8
480	B:B:G319	B:B:S277	3.71	No	No	0	5	5
481	B:B:S277	B:B:V320	4.85	No	No	0	5	7
482	B:B:F278	B:B:L285	10.96	Yes	Yes	0	7	6
483	B:B:S279	G:G:D48	10.31	No	Yes	24	9	9
484	B:B:S279	G:G:L50	6.01	No	No	24	9	9
485	B:B:S281	G:G:D48	8.83	No	Yes	0	9	9
486	B:B:D298	B:B:R283	10.72	Yes	Yes	9	9	9
487	B:B:L300	B:B:R283	8.5	No	Yes	0	6	9
488	B:B:R283	G:G:E42	4.65	Yes	No	9	9	1
489	B:B:L284	B:B:V296	5.96	No	No	0	5	5
490	B:B:L286	B:B:V296	4.47	No	No	0	7	5
491	B:B:L286	B:B:L318	6.92	No	No	0	7	6
492	B:B:L286	B:B:V327	4.47	No	No	0	7	6
493	B:B:A287	B:B:Y289	5.34	No	Yes	0	6	7
494	B:B:C294	B:B:G288	3.92	No	No	0	5	7
495	B:B:N295	B:B:Y289	11.63	Yes	Yes	18	6	7
496	B:B:W297	B:B:Y289	6.75	Yes	Yes	18	8	7
497	B:B:D290	B:B:R314	4.76	Yes	Yes	8	6	8
498	B:B:D291	B:B:N293	12.12	No	No	0	8	5
499	B:B:N293	B:B:N295	4.09	No	Yes	0	5	6
500	B:B:C294	B:B:V315	5.12	No	No	0	5	7
501	B:B:N295	B:B:W297	4.52	Yes	Yes	18	6	8
502	B:B:N295	B:B:R304	6.03	Yes	No	18	6	5
503	B:B:N295	B:B:V307	4.43	Yes	No	0	6	3
504	B:B:R304	B:B:W297	4	No	Yes	18	5	8
505	B:B:D298	B:B:K301	5.53	Yes	No	9	9	5
506	B:B:D298	B:B:D303	5.32	Yes	No	9	9	2
507	B:B:L300	G:G:C41	6.35	No	No	0	6	7
508	B:B:D303	B:B:K301	8.3	No	No	9	2	5
509	B:B:L308	B:B:W339	18.22	No	Yes	0	7	9
510	B:B:G310	B:B:K337	3.49	No	Yes	0	5	6
511	B:B:H311	B:B:V315	5.54	Yes	No	0	9	7
512	B:B:H311	B:B:T329	5.48	Yes	No	0	9	8
513	B:B:H311	B:B:S331	12.55	Yes	No	13	9	9
514	B:B:D333	B:B:H311	6.3	No	Yes	13	9	9
515	B:B:H311	B:B:K337	6.55	Yes	Yes	13	9	6
516	B:B:D312	B:B:D333	6.65	No	No	0	5	9
517	B:B:D312	R:R:H54	5.04	No	No	0	5	6
518	B:B:N313	B:B:W332	7.91	No	Yes	0	7	9
519	B:B:R314	B:B:W332	23.99	Yes	Yes	8	8	9
520	B:B:C317	B:B:S316	5.16	No	No	0	7	9
521	B:B:V320	B:B:V327	4.81	No	No	0	7	6
522	B:B:D323	B:B:T321	7.23	No	No	26	7	7
523	B:B:D323	B:B:M325	9.7	No	No	0	7	5
524	B:B:M325	G:G:P60	10.06	No	No	0	5	9
525	B:B:A326	G:G:F61	4.16	No	Yes	0	7	8
526	B:B:T329	B:B:W339	9.7	No	Yes	0	8	9
527	B:B:D333	B:B:S331	10.31	No	No	13	9	9
528	B:B:F335	B:B:S334	5.28	No	No	25	4	4
529	B:B:S334	R:R:R55	9.22	No	No	25	4	7
530	B:B:F335	R:R:R55	7.48	No	No	25	4	7
531	B:B:K337	B:B:W339	5.8	Yes	Yes	13	6	9
532	B:B:I338	G:G:F61	3.77	No	Yes	12	5	8
533	B:B:N340	G:G:V54	7.39	Yes	No	0	9	6
534	B:B:N340	G:G:N59	8.17	Yes	No	0	9	9
535	G:G:E17	G:G:K20	8.1	No	No	0	6	6
536	G:G:I28	G:G:K32	5.82	No	No	0	4	5
537	G:G:D36	G:G:K32	5.53	No	No	0	5	5
538	G:G:H44	G:G:Y40	13.07	No	Yes	0	6	6
539	G:G:E47	G:G:H44	4.92	No	No	0	3	6
540	G:G:D48	G:G:P49	4.83	Yes	No	0	9	7
541	G:G:D48	G:G:L50	8.14	Yes	No	24	9	9
542	G:G:D48	G:G:L51	4.07	Yes	No	0	9	6
543	G:G:P55	G:G:V54	3.53	No	No	0	5	6
544	G:G:E58	G:G:P55	22.01	No	No	0	5	5
545	G:G:N59	G:G:P60	4.89	No	No	0	9	9
546	G:G:F61	G:G:N59	6.04	Yes	No	0	8	9
547	L:L:?1	R:R:D106	16.71	Yes	No	1	0	7
548	L:L:?1	R:R:V107	9.88	Yes	No	0	0	6
549	L:L:?1	R:R:C110	9.02	Yes	No	1	0	6
550	L:L:?1	R:R:S188	7.11	Yes	No	0	0	7
551	L:L:?1	R:R:W285	5.39	Yes	Yes	1	0	8
552	L:L:?1	R:R:F288	11.54	Yes	No	1	0	7
553	L:L:?1	R:R:F289	10.38	Yes	Yes	1	0	7
554	L:L:?1	R:R:M292	6.7	Yes	No	0	0	7
555	L:L:?1	R:R:F312	12.69	Yes	Yes	1	0	6
556	L:L:?1	R:R:Y316	8.88	Yes	Yes	1	0	7
557	R:R:A84	R:R:L33	4.73	No	No	0	6	7
558	R:R:G34	R:R:I37	7.05	No	No	0	3	5
559	R:R:F39	R:R:G35	4.52	No	No	0	5	5
560	R:R:L317	R:R:L36	5.54	No	No	0	5	7
561	R:R:I37	R:R:L80	12.85	No	No	0	5	8
562	R:R:C320	R:R:G40	3.92	No	No	0	6	8
563	R:R:T76	R:R:V41	7.93	No	No	0	7	6
564	R:R:G43	R:R:L42	5.13	No	No	0	9	4
565	R:R:L42	R:R:L46	5.54	No	No	0	4	7
566	R:R:I48	R:R:N44	7.08	No	No	0	7	9
567	R:R:A69	R:R:N44	4.69	No	No	0	9	9
568	R:R:L73	R:R:N44	9.61	No	No	0	7	9
569	R:R:I45	R:R:L49	7.14	No	No	0	4	4
570	R:R:P323	R:R:V47	3.53	No	No	0	9	9
571	R:R:I48	R:R:V66	4.61	No	No	0	7	6
572	R:R:I48	R:R:V70	4.61	No	No	0	7	6
573	R:R:L57	R:R:V51	13.41	No	No	0	8	8
574	R:R:V51	R:R:V66	11.22	No	No	0	8	6
575	R:R:H54	R:R:H56	4.78	No	No	0	6	6
576	R:R:H54	R:R:L57	9	No	No	0	6	8
577	R:R:H58	R:R:R55	5.64	No	No	0	8	7
578	R:R:H56	R:R:H62	5.97	No	Yes	0	6	8
579	R:R:H62	R:R:L57	18	Yes	No	0	8	8
580	R:R:H62	R:R:S59	8.37	Yes	No	0	8	7
581	R:R:V60	R:R:Y64	6.31	No	Yes	0	7	8
582	R:R:V138	R:R:V60	4.81	No	No	0	6	7
583	R:R:H62	R:R:T61	4.11	Yes	No	0	8	8
584	R:R:D123	R:R:T61	4.34	No	No	0	9	8
585	R:R:I119	R:R:Y64	12.09	No	Yes	0	7	8
586	R:R:D123	R:R:Y64	6.9	No	Yes	0	9	8
587	R:R:L147	R:R:N67	13.73	No	No	27	8	9
588	R:R:N67	R:R:W151	11.3	No	Yes	27	9	9
589	R:R:D72	R:R:L68	5.43	Yes	No	1	9	9
590	R:R:L117	R:R:L68	5.54	Yes	No	1	8	9
591	R:R:L68	R:R:N322	5.49	No	Yes	1	9	9
592	R:R:D72	R:R:S113	5.89	Yes	No	0	9	9
593	R:R:D72	R:R:S319	7.36	Yes	No	0	9	9
594	R:R:D72	R:R:N322	8.08	Yes	Yes	1	9	9
595	R:R:L73	R:R:T76	4.42	No	No	0	7	7
596	R:R:L73	R:R:S77	4.5	No	No	0	7	5
597	R:R:C109	R:R:L74	4.76	No	No	0	6	6
598	R:R:C109	R:R:L75	6.35	No	No	0	6	8
599	R:R:L75	R:R:S319	7.51	No	No	0	8	9
600	R:R:L80	R:R:T76	5.9	No	No	0	8	7
601	R:R:T78	R:R:V105	4.76	No	No	0	6	5
602	R:R:V79	R:R:W102	6.13	Yes	No	0	8	5
603	R:R:D106	R:R:V79	13.15	No	Yes	1	7	8
604	R:R:V79	R:R:Y316	3.79	Yes	Yes	1	8	7
605	R:R:L80	R:R:Y316	8.21	No	Yes	0	8	7
606	R:R:F82	R:R:F94	5.36	No	Yes	0	5	5
607	R:R:F82	R:R:W102	5.01	No	No	0	5	5
608	R:R:S83	R:R:W102	3.71	No	No	0	7	5
609	R:R:S83	R:R:W313	6.18	No	Yes	1	7	6
610	R:R:S83	R:R:Y316	7.63	No	Yes	1	7	7
611	R:R:I85	R:R:L89	4.28	No	No	0	5	5
612	R:R:F86	R:R:W92	13.03	No	Yes	0	4	8
613	R:R:E87	R:R:W313	8.72	No	Yes	0	5	6
614	R:R:I175	R:R:Y91	3.63	No	No	0	5	4
615	R:R:F94	R:R:W92	4.01	Yes	Yes	0	5	8
616	R:R:G95	R:R:W92	4.22	No	Yes	0	8	8
617	R:R:C99	R:R:W92	19.59	No	Yes	28	9	8
618	R:R:C176	R:R:W92	5.22	No	Yes	28	9	8
619	R:R:F94	R:R:F98	4.29	Yes	No	0	5	5
620	R:R:R96	R:R:V97	3.92	No	No	0	5	3
621	R:R:E173	R:R:R96	3.49	No	No	0	4	5
622	R:R:C176	R:R:C99	7.28	No	No	28	9	9
623	R:R:I101	R:R:N100	4.25	No	No	0	5	6
624	R:R:L162	R:R:N100	6.87	No	No	0	5	6
625	R:R:N100	R:R:R166	4.82	No	Yes	0	6	5
626	R:R:D106	R:R:Y316	10.34	No	Yes	1	7	7
627	R:R:V107	R:R:Y184	3.79	No	Yes	0	6	8
628	R:R:L108	R:R:S158	9.01	No	No	0	6	8
629	R:R:C110	R:R:W285	5.22	No	Yes	1	6	8
630	R:R:S154	R:R:T111	6.4	No	No	0	8	7
631	R:R:S192	R:R:T111	9.59	No	No	0	6	7
632	R:R:A112	R:R:W151	5.19	No	Yes	0	8	9
633	R:R:F281	R:R:I114	3.77	Yes	No	1	9	8
634	R:R:I114	R:R:W285	15.27	No	Yes	1	8	8
635	R:R:M115	R:R:V150	6.09	No	No	0	6	6
636	R:R:F281	R:R:L117	3.65	Yes	Yes	1	9	8
637	R:R:L117	R:R:N322	9.61	Yes	Yes	1	8	9
638	R:R:L117	R:R:Y326	10.55	Yes	Yes	1	8	9
639	R:R:C118	R:R:I199	6.55	No	No	0	6	6
640	R:R:I120	R:R:R124	6.26	No	Yes	1	9	9
641	R:R:I120	R:R:Y326	6.04	No	Yes	1	9	9
642	R:R:M203	R:R:S121	4.6	No	No	0	6	9
643	R:R:S121	R:R:Y204	15.26	No	Yes	0	9	9
644	R:R:D123	R:R:Y134	9.2	No	Yes	0	9	7
645	R:R:R124	R:R:Y204	8.23	Yes	Yes	0	9	9
646	R:R:R124	R:R:Y326	6.17	Yes	Yes	1	9	9
647	R:R:S129	R:R:Y125	13.99	No	Yes	0	7	8
648	R:R:M203	R:R:Y125	13.17	No	Yes	0	6	8
649	R:R:R206	R:R:Y125	11.32	No	Yes	0	6	8
650	R:R:I126	R:R:Y130	4.84	No	No	0	5	6
651	R:R:I126	R:R:I137	4.42	No	No	0	5	5
652	R:R:I126	R:R:V138	4.61	No	No	0	5	6
653	R:R:G127	R:R:Y134	5.79	No	Yes	0	8	7
654	R:R:S129	R:R:Y130	6.36	No	No	0	7	6
655	R:R:L132	R:R:R133	3.64	Yes	No	0	7	5
656	R:R:P135	R:R:Y134	4.17	No	Yes	0	6	7
657	R:R:V138	R:R:Y134	11.36	No	Yes	0	6	7
658	R:R:L147	R:R:W151	4.56	No	Yes	27	8	9
659	R:R:F187	R:R:I157	7.54	No	No	0	5	6
660	R:R:G160	R:R:P161	4.06	No	Yes	0	7	7
661	R:R:P161	R:R:R166	4.32	Yes	Yes	15	7	5
662	R:R:N179	R:R:P161	8.15	Yes	Yes	15	5	7
663	R:R:P161	R:R:Y184	11.13	Yes	Yes	15	7	8
664	R:R:Q167	R:R:R166	8.18	Yes	Yes	15	5	5
665	R:R:N179	R:R:R166	13.26	Yes	Yes	15	5	5
666	R:R:Q167	R:R:Q177	3.84	Yes	No	0	5	5
667	R:R:N179	R:R:Q167	3.96	Yes	Yes	15	5	5
668	R:R:I175	R:R:T174	4.56	No	No	0	5	1
669	R:R:E180	R:R:Q177	5.1	No	No	0	5	5
670	R:R:E180	R:R:I178	5.47	No	No	0	5	6
671	R:R:F312	R:R:I178	5.02	Yes	No	0	6	6
672	R:R:N179	R:R:Y184	17.44	Yes	Yes	15	5	8
673	R:R:S188	R:R:Y184	12.72	No	Yes	0	7	8
674	R:R:M292	R:R:V185	6.09	No	No	0	7	6
675	R:R:S296	R:R:V185	9.7	No	No	0	5	6
676	R:R:G191	R:R:L190	5.13	No	No	0	5	4
677	R:R:F289	R:R:S192	5.28	Yes	No	0	7	6
678	R:R:F193	R:R:Y194	7.22	Yes	No	0	8	6
679	R:R:F193	R:R:L197	12.18	Yes	No	1	8	6
680	R:R:F193	R:R:F281	4.29	Yes	Yes	1	8	9
681	R:R:F193	R:R:W285	5.01	Yes	Yes	1	8	8
682	R:R:F193	R:R:L286	7.31	Yes	Yes	0	8	7
683	R:R:F193	R:R:F289	18.22	Yes	Yes	1	8	7
684	R:R:L195	R:R:P196	6.57	No	No	0	5	9
685	R:R:L197	R:R:L201	5.54	No	No	0	6	5
686	R:R:F281	R:R:L197	3.65	Yes	No	1	9	6
687	R:R:F281	R:R:I200	5.02	Yes	No	0	9	8
688	R:R:R206	R:R:V202	3.92	No	No	0	6	4
689	R:R:L274	R:R:Y204	12.89	No	Yes	0	9	9
690	R:R:V277	R:R:Y204	3.79	No	Yes	0	8	9
691	R:R:V278	R:R:Y204	5.05	No	Yes	0	8	9
692	R:R:A271	R:R:Y208	5.34	No	No	0	7	5
693	R:R:L274	R:R:Y208	3.52	No	No	0	9	5
694	R:R:R213	R:R:V210	3.92	No	No	0	5	6
695	R:R:E214	R:R:R213	11.63	Yes	No	14	7	5
696	R:R:K269	R:R:K272	5.75	No	No	0	8	7
697	R:R:K269	R:R:T273	4.5	No	No	0	8	9
698	R:R:V277	R:R:Y326	3.79	No	Yes	0	8	9
699	R:R:C280	R:R:I321	4.91	No	No	0	7	6
700	R:R:F281	R:R:W285	5.01	Yes	Yes	1	9	8
701	R:R:F289	R:R:W285	5.01	Yes	Yes	1	7	8
702	R:R:G315	R:R:W285	8.44	No	Yes	0	7	8
703	R:R:N318	R:R:W285	11.3	Yes	Yes	0	9	8
704	R:R:L286	R:R:L290	8.3	Yes	No	0	7	6
705	R:R:F288	R:R:V311	10.49	No	No	0	7	5
706	R:R:F288	R:R:F312	16.08	No	Yes	1	7	6
707	R:R:P303	R:R:V291	3.53	Yes	No	0	4	5
708	R:R:V291	R:R:V311	8.02	No	No	0	5	5
709	R:R:M292	R:R:P293	11.74	No	No	0	7	6
710	R:R:F298	R:R:I294	7.54	No	Yes	0	4	5
711	R:R:F297	R:R:F298	4.29	No	No	0	5	4
712	R:R:P303	R:R:V307	3.53	Yes	No	0	4	5
713	R:R:I310	R:R:K309	5.82	No	No	0	5	5
714	R:R:K309	R:R:W313	5.8	No	Yes	0	5	6
715	R:R:F312	R:R:Y316	5.16	Yes	Yes	1	6	7
716	R:R:W313	R:R:Y316	8.68	Yes	Yes	1	6	7
717	R:R:N318	R:R:S319	4.47	Yes	No	0	9	9
718	R:R:N318	R:R:N322	12.26	Yes	Yes	0	9	9
719	R:R:I321	R:R:I325	5.89	No	No	0	6	8
720	R:R:I325	R:R:Y326	4.84	No	Yes	0	8	9
721	A:A:C365	A:A:V367	3.42	No	No	0	8	9
722	B:B:C103	B:B:V71	3.42	No	No	0	8	8
723	R:R:G34	R:R:L33	3.42	No	No	0	3	7
724	R:R:A112	R:R:S154	3.42	No	No	0	8	8
725	R:R:G183	R:R:L186	3.42	No	No	0	5	6
726	A:A:A269	A:A:V248	3.39	No	No	0	9	7
727	A:A:A298	A:A:V334	3.39	No	No	0	4	4
728	A:A:I383	R:R:P131	3.39	No	No	0	8	8
729	A:A:V394	R:R:A270	3.39	No	No	0	8	8
730	B:B:A73	B:B:V100	3.39	No	No	0	9	9
731	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
732	B:B:A305	B:B:V296	3.39	No	No	0	4	5
733	R:R:I37	R:R:P81	3.39	No	No	0	5	9
734	R:R:A69	R:R:V47	3.39	No	No	0	9	9
735	R:R:I114	R:R:P196	3.39	No	No	0	8	9
736	R:R:I294	R:R:P303	3.39	Yes	Yes	0	5	4
737	B:B:C149	B:B:T159	3.38	No	Yes	0	8	9
738	R:R:Q140	R:R:Y63	3.38	No	No	0	4	5
739	R:R:M115	R:R:P196	3.35	No	No	0	6	9
740	R:R:K302	R:R:P303	3.35	No	Yes	0	3	4
741	R:R:L286	R:R:P287	3.28	Yes	No	0	7	9
742	R:R:L314	R:R:P287	3.28	No	No	0	7	9
743	R:R:C118	R:R:I122	3.27	No	No	0	6	6
744	R:R:C118	R:R:I200	3.27	No	No	0	6	8
745	B:B:S147	B:B:S160	3.26	No	No	0	9	6
746	A:A:I26	B:B:A92	3.25	No	No	0	9	6
747	A:A:A243	A:A:I288	3.25	No	Yes	0	8	9
748	B:B:I18	G:G:A23	3.25	No	No	0	7	8
749	R:R:A146	R:R:I119	3.25	No	No	0	6	7
750	R:R:S158	R:R:V107	3.23	No	No	0	8	6
751	A:A:D331	A:A:P332	3.22	No	No	0	4	1
752	R:R:F308	R:R:F312	3.22	No	Yes	0	4	6
753	R:R:V128	R:R:V210	3.21	No	No	0	8	6
754	R:R:T78	R:R:V79	3.17	No	Yes	0	6	8
755	R:R:C149	R:R:L153	3.17	No	No	0	2	5
756	R:R:P168	R:R:Q167	3.16	No	Yes	0	4	5
757	B:B:L7	G:G:A12	3.15	Yes	No	0	8	5
758	B:B:L30	G:G:A34	3.15	No	No	0	5	6
759	B:B:A242	B:B:L285	3.15	No	Yes	0	4	6
760	R:R:A104	R:R:L162	3.15	No	No	0	6	5
761	R:R:C284	R:R:N318	3.15	No	Yes	0	8	9
762	R:R:E181	R:R:P182	3.14	No	No	0	6	4
763	A:A:I341	A:A:S250	3.1	No	No	0	8	6
764	A:A:I276	A:A:S275	3.1	No	No	0	8	8
765	B:B:I33	G:G:S31	3.1	No	No	0	3	9
766	B:B:A193	B:B:D195	3.09	No	No	0	4	5
767	B:B:I43	B:B:V40	3.07	No	Yes	0	3	3
768	A:A:K300	A:A:S306	3.06	No	No	0	9	7
769	B:B:C218	G:G:Q18	3.05	No	No	0	5	9
770	R:R:I157	R:R:T111	3.04	No	No	0	6	7
771	B:B:F234	B:B:G238	3.01	Yes	No	0	5	7
772	A:A:N278	A:A:S352	2.98	No	No	0	8	5
773	A:A:L302	A:A:V334	2.98	No	No	0	2	4
774	A:A:L388	R:R:V128	2.98	No	No	0	8	8
775	B:B:L285	B:B:V276	2.98	Yes	No	0	6	6
776	R:R:L286	R:R:V282	2.98	Yes	No	0	7	5
777	A:A:L393	R:R:T273	2.95	No	No	0	8	9
778	B:B:L152	B:B:T196	2.95	No	No	0	3	1
779	A:A:I245	A:A:I288	2.94	Yes	Yes	0	7	9
780	G:G:A43	G:G:H44	2.93	No	No	0	4	6
781	B:B:G109	B:B:Y105	2.9	No	Yes	0	5	6
782	R:R:G143	R:R:Y64	2.9	No	Yes	0	7	8
783	B:B:D322	B:B:T65	2.89	No	No	0	1	1
784	R:R:F297	R:R:P182	2.89	No	No	0	5	4
785	B:B:E138	B:B:S122	2.87	No	No	0	6	8
786	G:G:E58	G:G:S57	2.87	No	No	0	5	6
787	R:R:I45	R:R:L46	2.85	No	No	0	4	7
788	A:A:I383	A:A:N387	2.83	No	No	0	8	8
789	B:B:L14	G:G:K20	2.82	No	No	0	8	6
790	R:R:G160	R:R:W165	2.81	No	No	0	7	6
791	B:B:D118	B:B:I120	2.8	No	No	0	9	6
792	A:A:A337	A:A:F315	2.77	No	Yes	0	8	6
793	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
794	B:B:A208	B:B:F222	2.77	No	Yes	2	6	8
795	B:B:A208	B:B:F241	2.77	No	Yes	2	6	6
796	G:G:L15	G:G:L19	2.77	No	No	0	2	9
797	R:R:A169	R:R:R96	2.77	No	No	0	3	5
798	R:R:A189	R:R:F289	2.77	No	Yes	0	7	7
799	R:R:L314	R:R:L317	2.77	No	No	0	7	5
800	B:B:Q220	G:G:I25	2.74	Yes	No	0	7	2
801	G:G:M21	G:G:Q18	2.72	No	No	0	1	9
802	A:A:E390	A:A:M386	2.71	No	No	0	4	4
803	A:A:E21	A:A:K24	2.7	No	No	0	3	4
804	B:B:E10	G:G:K20	2.7	No	No	0	8	6
805	R:R:L144	R:R:Q140	2.66	No	No	0	5	4
806	A:A:H362	A:A:I288	2.65	No	Yes	0	9	9
807	B:B:D20	B:B:Q17	2.61	No	No	0	2	4
808	B:B:D258	G:G:E22	2.6	Yes	No	0	7	9
809	R:R:A71	R:R:W151	2.59	No	Yes	0	8	9
810	R:R:R133	R:R:T136	2.59	No	No	0	5	4
811	R:R:V207	R:R:Y125	2.52	No	Yes	0	9	8
812	A:A:I26	A:A:R22	2.51	No	No	0	9	4
813	A:A:F273	A:A:I348	2.51	Yes	No	0	9	4
814	B:B:I171	B:B:R137	2.51	Yes	No	0	6	5
815	R:R:F163	R:R:I159	2.51	No	No	0	4	4
816	R:R:F301	R:R:I294	2.51	No	Yes	0	3	5
817	R:R:H58	R:R:Q140	2.47	No	No	0	8	4
818	B:B:L198	B:B:R197	2.43	No	No	0	3	5
819	R:R:I65	R:R:Y326	2.42	No	Yes	0	7	9
820	A:A:D49	A:A:R265	2.38	No	Yes	0	8	9
821	A:A:L393	A:A:Y391	2.34	No	No	0	8	4
822	B:B:E130	B:B:R134	2.33	No	No	0	3	3
823	G:G:E17	G:G:R13	2.33	No	No	0	6	6
824	A:A:R280	A:A:R283	2.13	No	No	0	5	3
825	B:B:G115	B:B:G116	2.11	No	No	0	9	9
826	R:R:G34	R:R:G35	2.11	No	No	0	3	5
827	B:B:G324	G:G:P49	2.03	No	No	0	9	7
828	R:R:G183	R:R:P182	2.03	No	No	0	5	4
829	B:B:C114	B:B:G115	1.96	No	No	0	8	9
830	B:B:C204	B:B:G185	1.96	No	No	0	7	5
831	B:B:C317	B:B:G330	1.96	No	No	0	7	5
832	A:A:A37	A:A:G34	1.95	No	No	0	3	5
833	A:A:A303	A:A:G304	1.95	No	No	0	5	5
834	B:B:A140	B:B:G141	1.95	No	No	0	5	5
835	B:B:A305	B:B:G306	1.95	No	No	0	4	4
836	B:B:A309	B:B:G310	1.95	No	No	0	3	5
837	R:R:A169	R:R:P170	1.87	No	No	0	3	4
838	B:B:G144	B:B:S161	1.86	No	Yes	0	8	9
839	A:A:G225	A:A:V224	1.84	No	No	0	9	9
840	B:B:G41	B:B:V40	1.84	No	Yes	0	1	3
841	R:R:G279	R:R:V278	1.84	No	No	0	5	8
842	B:B:G131	B:B:T128	1.82	No	No	0	4	3
843	B:B:G185	B:B:T164	1.82	No	No	0	5	6
844	B:B:G182	B:B:T181	1.82	No	No	0	6	2
845	B:B:G224	B:B:T223	1.82	No	No	0	6	2
846	R:R:A211	R:R:A270	1.79	No	No	0	8	8
847	A:A:P361	A:A:V346	1.77	No	No	0	5	4
848	R:R:G116	R:R:I119	1.76	No	No	0	7	7
849	R:R:G191	R:R:I157	1.76	No	No	0	5	6
850	R:R:G295	R:R:I294	1.76	No	Yes	0	4	5
851	G:G:P53	G:G:T52	1.75	No	No	0	8	4
852	A:A:G52	A:A:K293	1.74	No	No	0	9	9
853	B:B:G324	B:B:K280	1.74	No	No	0	9	1
854	A:A:G34	B:B:L55	1.71	No	No	0	5	6
855	R:R:G35	R:R:L38	1.71	No	No	0	5	4
856	R:R:G275	R:R:L274	1.71	No	No	0	6	9
857	B:B:A11	G:G:V16	1.7	No	No	0	5	7
858	B:B:A231	B:B:V276	1.7	No	No	0	5	6
859	A:A:D354	A:A:G353	1.68	No	No	0	3	4
860	B:B:G141	B:B:Q176	1.64	No	Yes	0	5	4
861	B:B:A248	B:B:I269	1.62	No	No	0	5	4
862	R:R:S304	R:R:V307	1.62	No	No	0	5	5
863	A:A:S54	A:A:T55	1.6	No	No	0	9	9
864	B:B:S31	B:B:T29	1.6	No	No	0	1	3
865	R:R:S304	R:R:T306	1.6	No	No	0	5	1
866	A:A:T350	A:A:V346	1.59	No	No	0	4	4
867	R:R:C284	R:R:L283	1.59	No	No	0	8	5
868	B:B:L14	G:G:A23	1.58	No	No	0	8	8
869	A:A:T319	A:A:T320	1.57	No	No	0	5	1
870	A:A:A19	B:B:N88	1.56	No	Yes	0	5	7
871	A:A:A20	B:B:N88	1.56	No	Yes	0	3	7
872	G:G:A23	G:G:N24	1.56	No	No	0	8	1
873	A:A:I308	A:A:V301	1.54	Yes	No	0	7	7
874	B:B:A21	B:B:D20	1.54	No	No	0	4	2
875	R:R:I276	R:R:V277	1.54	No	No	0	7	8
876	B:B:K301	B:B:S31	1.53	No	No	0	5	1
877	A:A:K17	A:A:V12	1.52	No	No	0	4	1
878	A:A:I285	A:A:T284	1.52	No	No	0	7	4
879	A:A:A316	A:A:E309	1.51	No	No	0	2	4
880	G:G:A45	G:G:E42	1.51	No	No	0	4	1
881	R:R:F39	R:R:G40	1.51	No	No	0	5	8
882	R:R:F163	R:R:G160	1.51	No	No	0	4	7
883	B:B:N35	B:B:S31	1.49	No	No	0	1	1
884	R:R:L33	R:R:V88	1.49	No	No	0	7	5
885	R:R:L155	R:R:V156	1.49	No	No	0	4	4
886	G:G:L51	G:G:T52	1.47	No	No	0	6	4
887	A:A:D16	A:A:V12	1.46	No	No	0	4	1
888	A:A:N392	R:R:T273	1.46	No	No	0	7	9
889	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
890	R:R:D172	R:R:T174	1.45	No	No	0	3	1
891	A:A:E15	A:A:S13	1.44	No	No	0	5	7
892	A:A:F312	A:A:P313	1.44	Yes	No	0	8	6
893	R:R:F298	R:R:P299	1.44	No	No	0	4	2
894	R:R:E305	R:R:S304	1.44	No	No	0	2	5
895	B:B:L4	G:G:I9	1.43	No	No	0	4	2
896	B:B:L7	G:G:I9	1.43	Yes	No	0	8	2
897	B:B:I18	G:G:L19	1.43	No	No	0	7	9
898	R:R:I159	R:R:L155	1.43	No	No	0	4	4
899	B:B:I37	B:B:N36	1.42	Yes	No	0	2	1
900	A:A:G353	A:A:W277	1.41	No	Yes	0	4	6
901	R:R:L153	R:R:M115	1.41	No	No	0	5	6
902	A:A:K274	A:A:N278	1.4	No	No	0	5	8
903	R:R:A93	R:R:F94	1.39	No	Yes	0	3	5
904	R:R:P327	R:R:Y326	1.39	No	Yes	0	7	9
905	A:A:A48	A:A:R265	1.38	No	Yes	0	8	9
906	A:A:D310	A:A:K307	1.38	No	No	0	3	6
907	G:G:A10	G:G:R13	1.38	No	No	0	2	6
908	R:R:A169	R:R:R166	1.38	No	Yes	0	3	5
909	B:B:D20	B:B:N16	1.35	No	No	0	2	1
910	B:B:L7	B:B:Q6	1.33	Yes	No	0	8	1
911	B:B:E10	B:B:L7	1.33	No	Yes	0	8	8
912	B:B:A299	B:B:Y264	1.33	No	Yes	0	5	5
913	R:R:D172	R:R:E171	1.3	No	No	0	3	3
914	A:A:R283	A:A:T284	1.29	No	No	0	3	4
915	R:R:R142	R:R:T139	1.29	No	No	0	6	7
916	B:B:D267	B:B:H266	1.26	No	No	0	3	4
917	B:B:K23	B:B:R19	1.24	No	No	0	2	4
918	A:A:N392	A:A:R389	1.21	No	No	0	7	5
919	B:B:F292	B:B:N313	1.21	No	No	0	4	7
920	A:A:D27	A:A:R31	1.19	No	No	0	6	4
921	R:R:K212	R:R:Y208	1.19	No	No	0	5	5
922	A:A:E309	A:A:F315	1.17	No	Yes	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:I207	4.805	4	20	9
2	A:A:D215	7.95	4	10	5
3	A:A:F219	7.024	5	0	8
4	A:A:K233	5.1125	4	3	9
5	A:A:W234	6.902	5	0	9
6	A:A:F238	9.2225	4	0	9
7	A:A:I244	4.315	4	19	8
8	A:A:I245	4.21	4	5	7
9	A:A:Y253	8.71	4	0	8
10	A:A:R265	4.064	5	21	9
11	A:A:F273	4.98	6	6	9
12	A:A:W277	9.616	5	6	6
13	A:A:I288	7.4575	4	0	9
14	A:A:F290	6.262	5	5	9
15	A:A:I308	7.21	4	0	7
16	A:A:F312	5.005	4	0	8
17	A:A:F315	7.656	5	0	6
18	A:A:Y339	5.124	5	23	3
19	A:A:F345	6.2525	4	6	8
20	A:A:F363	11.625	4	6	5
21	A:A:F376	7.858	5	10	8
22	B:B:L7	1.81	4	0	8
23	B:B:I37	5.7125	4	9	2
24	B:B:V40	5.228	5	9	3
25	B:B:R49	7.6125	4	12	7
26	B:B:H54	9.795	4	7	9
27	B:B:K57	10.2225	4	8	9
28	B:B:Y59	5.96	4	8	8
29	B:B:M61	4.85	4	0	6
30	B:B:W63	7.255	4	0	7
31	B:B:R68	6.5075	4	12	5
32	B:B:W82	9.36429	7	7	9
33	B:B:Y85	7.0975	4	12	4
34	B:B:N88	5.2025	4	0	7
35	B:B:K89	8.544	5	7	9
36	B:B:I93	6.5575	4	11	7
37	B:B:L95	4.9025	4	0	8
38	B:B:W99	7.89833	6	20	9
39	B:B:Y105	4.535	6	11	6
40	B:B:Y111	6.38	5	0	4
41	B:B:I123	4.74	4	3	6
42	B:B:Y124	4.82857	7	11	6
43	B:B:L126	4.5575	4	11	5
44	B:B:V133	7.2125	4	11	4
45	B:B:H142	7.97167	6	3	9
46	B:B:Y145	6.06833	6	3	8
47	B:B:R150	5.685	4	0	6
48	B:B:F151	4.77	7	3	9
49	B:B:I157	4.345	4	3	7
50	B:B:T159	6.695	4	3	9
51	B:B:S161	6.7375	4	3	9
52	B:B:D163	8.48	4	3	9
53	B:B:L168	4.6575	4	4	6
54	B:B:W169	11.23	6	3	8
55	B:B:I171	4.1475	4	3	6
56	B:B:Q176	7.042	5	3	4
57	B:B:F180	8.662	5	4	7
58	B:B:H183	9.2775	4	4	9
59	B:B:F199	8.26	5	4	9
60	B:B:K209	9.028	5	4	6
61	B:B:W211	8.78833	6	4	8
62	B:B:D212	9.2725	4	16	9
63	B:B:Q220	8.3475	4	2	7
64	B:B:F222	8.8	5	2	8
65	B:B:H225	10.95	7	2	9
66	B:B:D228	6.815	4	0	9
67	B:B:I229	5.945	4	2	7
68	B:B:I232	5.47	4	2	8
69	B:B:F234	5.87	5	0	5
70	B:B:F235	8.78	4	17	6
71	B:B:P236	6.7525	4	17	7
72	B:B:F241	7.584	5	2	6
73	B:B:T243	6.6575	4	2	8
74	B:B:D247	7.9275	4	2	9
75	B:B:R251	22.4925	4	2	8
76	B:B:F253	12.185	6	2	6
77	B:B:D258	9.396	5	2	7
78	B:B:Q259	7.7225	4	0	6
79	B:B:Y264	7.04667	6	0	5
80	B:B:F278	7.645	4	17	7
81	B:B:R283	7.836	5	9	9
82	B:B:L285	5.445	4	0	6
83	B:B:Y289	7.04333	6	18	7
84	B:B:D290	4.7	4	8	6
85	B:B:N295	6.14	5	18	6
86	B:B:W297	6.23	4	18	8
87	B:B:D298	7.9475	4	9	9
88	B:B:H311	7.284	5	13	9
89	B:B:R314	10.295	4	8	8
90	B:B:W332	9.97	6	8	9
91	B:B:K337	5.872	5	13	6
92	B:B:W339	8.898	5	13	9
93	B:B:N340	7.1	4	0	9
94	G:G:R27	11.4525	4	2	8
95	G:G:Y40	9.38	4	17	6
96	G:G:D48	7.236	5	24	9
97	G:G:F61	5.48667	6	12	8
98	L:L:?1	9.83	10	1	0
99	R:R:H62	9.1125	4	0	8
100	R:R:Y64	7.05	4	0	8
101	R:R:D72	6.69	4	1	9
102	R:R:V79	6.56	4	1	8
103	R:R:W92	9.214	5	28	8
104	R:R:F94	3.7625	4	0	5
105	R:R:L117	7.3375	4	1	8
106	R:R:R124	8.2525	4	1	9
107	R:R:Y125	10.25	4	0	8
108	R:R:L132	5.57	4	10	7
109	R:R:Y134	7.63	4	0	7
110	R:R:W151	5.91	4	27	9
111	R:R:P161	6.915	4	15	7
112	R:R:R166	6.392	5	15	5
113	R:R:Q167	4.785	4	15	5
114	R:R:N179	10.7025	4	15	5
115	R:R:Y184	11.27	4	15	8
116	R:R:F193	9.03833	6	1	8
117	R:R:Y204	9.044	5	0	9
118	R:R:E214	11.3425	4	14	7
119	R:R:F281	4.23167	6	1	9
120	R:R:W285	7.58125	8	1	8
121	R:R:L286	5.4675	4	0	7
122	R:R:F289	8.332	5	1	7
123	R:R:I294	3.8	4	0	5
124	R:R:P303	3.45	4	0	4
125	R:R:F312	8.434	5	1	6
126	R:R:W313	7.345	4	1	6
127	R:R:Y316	7.52714	7	1	7
128	R:R:N318	7.795	4	0	9
129	R:R:N322	8.86	4	1	9
130	R:R:Y326	5.02857	7	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:H54	B:B:S74	94.272	9.76	Yes	No	0	9	9
2	B:B:D76	B:B:S74	94.2662	8.83	No	No	0	9	9
3	B:B:H54	B:B:W82	92.8543	4.23	Yes	Yes	7	9	9
4	B:B:N340	G:G:N59	100	8.17	Yes	No	0	9	9
5	B:B:M45	B:B:N340	99.6928	5.61	No	Yes	0	4	9
6	B:B:M45	B:B:W339	98.2991	3.49	No	Yes	0	4	9
7	B:B:T329	B:B:W339	48.081	9.7	No	Yes	0	8	9
8	B:B:H311	B:B:T329	47.986	5.48	Yes	No	0	9	8
9	B:B:D333	B:B:H311	95.3768	6.3	No	Yes	13	9	9
10	B:B:D312	B:B:D333	95.1833	6.65	No	No	0	5	9
11	B:B:D312	R:R:H54	94.9492	5.04	No	No	0	5	6
12	R:R:H54	R:R:H56	14.083	4.78	No	No	0	6	6
13	R:R:H56	R:R:H62	13.2814	5.97	No	Yes	0	6	8
14	B:B:Y85	G:G:F61	19.3792	6.19	Yes	Yes	12	4	8
15	G:G:F61	G:G:N59	90.421	6.04	Yes	No	0	8	9
16	B:B:L70	B:B:W82	90.6345	5.69	No	Yes	0	5	9
17	B:B:L70	B:B:W63	90.6323	7.97	No	Yes	0	5	7
18	B:B:S84	B:B:W63	91.6158	4.94	No	Yes	0	5	7
19	B:B:S84	G:G:F61	91.6107	5.28	No	Yes	0	5	8
20	B:B:K337	B:B:W339	49.9824	5.8	Yes	Yes	13	6	9
21	B:B:H311	B:B:K337	48.6007	6.55	Yes	Yes	13	9	6
22	R:R:H54	R:R:L57	80.7982	9	No	No	0	6	8
23	R:R:H62	R:R:L57	13.6146	18	Yes	No	0	8	8
24	B:B:A56	B:B:D76	94.2114	6.18	No	No	0	7	9
25	B:B:A56	B:B:Q75	94.2035	6.06	No	No	0	7	9
26	B:B:Q75	B:B:Y59	77.2263	7.89	No	Yes	8	9	8
27	A:A:C237	B:B:Y59	70.5438	5.38	No	Yes	0	8	8
28	A:A:C237	B:B:W99	70.4816	5.22	No	Yes	0	8	9
29	A:A:F238	B:B:W99	68.8969	12.03	Yes	Yes	0	9	9
30	A:A:F238	A:A:L44	31.0714	14.61	Yes	No	0	9	9
31	A:A:L44	A:A:L46	30.1494	11.07	No	No	19	9	8
32	A:A:I276	A:A:L46	30.2301	4.28	No	No	0	8	8
33	A:A:F246	A:A:I276	30.0235	3.77	No	No	0	9	8
34	A:A:F246	A:A:F273	61.3825	6.43	No	Yes	0	9	9
35	A:A:C359	A:A:F273	55.6059	4.19	No	Yes	0	5	9
36	A:A:C359	A:A:P361	55.1176	3.77	No	No	0	5	5
37	A:A:P361	A:A:R342	54.3804	7.21	No	No	0	5	4
38	A:A:R342	A:A:Y339	54.3194	7.2	No	Yes	0	4	3
39	A:A:Y318	A:A:Y339	53.0819	3.97	No	Yes	0	6	3
40	A:A:F340	A:A:Y318	52.3366	13.41	No	No	0	7	6
41	A:A:F312	A:A:F340	25.5049	7.5	Yes	No	0	8	7
42	A:A:F312	A:A:I308	24.4615	3.77	Yes	Yes	0	8	7
43	A:A:I308	A:A:Y253	45.2169	8.46	Yes	Yes	0	7	8
44	A:A:Y253	A:A:Y311	42.0017	10.92	Yes	No	0	8	6
45	A:A:N264	A:A:Y311	41.465	4.65	No	No	0	9	6
46	A:A:D252	A:A:N264	38.1994	5.39	No	No	21	8	9
47	A:A:D249	A:A:D252	37.7018	3.99	No	No	0	8	8
48	A:A:D249	A:A:K293	34.467	11.06	No	No	0	8	9
49	A:A:K293	A:A:N292	33.3869	6.99	No	No	0	9	9
50	A:A:I56	A:A:N292	30.6566	5.66	No	No	5	7	9
51	A:A:F290	A:A:I56	30.1411	3.77	Yes	No	5	9	7
52	A:A:F290	A:A:I245	25.7969	3.77	Yes	Yes	5	9	7
53	A:A:I245	A:A:L43	20.3554	5.71	Yes	No	0	7	7
54	A:A:F219	A:A:L43	19.8094	3.65	Yes	No	0	8	7
55	A:A:F238	A:A:W234	38.1379	5.01	Yes	Yes	0	9	9
56	A:A:R231	A:A:W234	31.85	4	No	Yes	0	9	9
57	A:A:D272	A:A:R231	31.7395	8.34	No	No	0	8	9
58	A:A:D272	A:A:F246	31.6318	7.17	No	No	0	8	9
59	A:A:F315	A:A:F340	26.5901	11.79	Yes	No	0	6	7
60	A:A:F315	A:A:I308	24.5033	15.07	Yes	Yes	0	6	7
61	B:B:K57	B:B:Q75	16.9689	18.98	Yes	No	8	9	9
62	B:B:K57	B:B:W332	16.6044	11.6	Yes	Yes	8	9	9
63	B:B:W332	B:B:Y59	26.3801	5.79	Yes	Yes	8	9	8
64	B:B:R314	B:B:W332	41.3725	23.99	Yes	Yes	8	8	9
65	R:R:H62	R:R:T61	25.0179	4.11	Yes	No	0	8	8
66	R:R:D123	R:R:T61	24.4488	4.34	No	No	0	9	8
67	R:R:D123	R:R:Y134	20.4628	9.2	No	Yes	0	9	7
68	R:R:V138	R:R:Y134	18.8155	11.36	No	Yes	0	6	7
69	R:R:I126	R:R:V138	18.4274	4.61	No	No	0	5	6
70	R:R:I126	R:R:Y130	17.4285	4.84	No	No	0	5	6
71	R:R:S129	R:R:Y130	16.933	6.36	No	No	0	7	6
72	R:R:S129	R:R:Y125	16.4378	13.99	No	Yes	0	7	8
73	R:R:M203	R:R:Y125	14.4578	13.17	No	Yes	0	6	8
74	R:R:M203	R:R:S121	13.9636	4.6	No	No	0	6	9
75	R:R:S121	R:R:Y204	13.4699	15.26	No	Yes	0	9	9
76	B:B:D290	B:B:R314	40.5723	4.76	Yes	Yes	8	6	8
77	B:B:C271	B:B:D290	40.054	4.67	No	Yes	0	5	6
78	B:B:C271	B:B:Y289	39.2326	4.03	No	Yes	0	5	7
79	B:B:W297	B:B:Y289	35.5966	6.75	Yes	Yes	18	8	7
80	B:B:W297	B:B:Y264	34.2983	9.65	Yes	Yes	0	8	5
81	B:B:M262	B:B:Y264	20.7056	14.37	No	Yes	0	4	5
82	B:B:L30	B:B:M262	20.1447	7.07	No	No	0	5	4
83	B:B:L261	B:B:L30	17.9028	4.15	No	No	0	5	5
84	B:B:L261	B:B:Q259	16.7776	3.99	No	Yes	0	5	6
85	B:B:Q259	G:G:R27	15.9324	15.19	Yes	Yes	0	6	8
86	B:B:D258	G:G:R27	15.0805	3.57	Yes	Yes	2	7	8
87	B:B:L69	B:B:R68	26.26	4.86	No	Yes	0	5	5
88	B:B:L69	B:B:Y105	25.9851	7.03	No	Yes	0	5	6
89	B:B:H62	B:B:Y105	15.0828	4.36	No	Yes	0	6	6
90	B:B:H62	B:B:R150	14.7985	11.28	No	Yes	0	6	6
91	B:B:L192	B:B:R150	11.33	3.64	No	Yes	0	5	6
92	B:B:L285	B:B:Y264	12.9699	4.69	Yes	Yes	0	6	5
93	B:B:F278	B:B:L285	11.8225	10.96	Yes	Yes	0	7	6
94	R:R:L57	R:R:V51	67.8059	13.41	No	No	0	8	8
95	R:R:V51	R:R:V66	67.5566	11.22	No	No	0	8	6
96	R:R:I48	R:R:V66	67.31	4.61	No	No	0	7	6
97	R:R:I48	R:R:N44	66.8166	7.08	No	No	0	7	9
98	R:R:L73	R:R:N44	65.8284	9.61	No	No	0	7	9
99	R:R:L73	R:R:T76	65.3357	4.42	No	No	0	7	7
100	R:R:L80	R:R:T76	64.8428	5.9	No	No	0	8	7
101	R:R:L80	R:R:Y316	61.87	8.21	No	Yes	0	8	7
102	L:L:?1	R:R:Y316	46.9221	8.88	Yes	Yes	1	0	7
103	L:L:?1	R:R:V107	10.2953	9.88	Yes	No	0	0	6
104	L:L:?1	R:R:W285	15.3868	5.39	Yes	Yes	1	0	8
105	R:R:P161	R:R:Y184	10.3053	11.13	Yes	Yes	15	7	8
106	R:R:F288	R:R:V311	10.6569	10.49	No	No	0	7	5
107	R:R:V291	R:R:V311	10.0668	8.02	No	No	0	5	5
108	B:B:R68	B:B:Y85	26.6563	9.26	Yes	Yes	12	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D106	16.71	1	Yes	No	0	7	0	1
L:L:?1	R:R:V107	9.88	1	Yes	No	0	6	0	1
L:L:?1	R:R:C110	9.02	1	Yes	No	0	6	0	1
L:L:?1	R:R:S188	7.11	1	Yes	No	0	7	0	1
L:L:?1	R:R:W285	5.39	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F288	11.54	1	Yes	No	0	7	0	1
L:L:?1	R:R:F289	10.38	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:M292	6.7	1	Yes	No	0	7	0	1
L:L:?1	R:R:F312	12.69	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y316	8.88	1	Yes	Yes	0	7	0	1
R:R:D106	R:R:V79	13.15	1	No	Yes	7	8	1	2
R:R:V79	R:R:Y316	3.79	1	Yes	Yes	8	7	2	1
R:R:L80	R:R:Y316	8.21	0	No	Yes	8	7	2	1
R:R:S83	R:R:W313	6.18	1	No	Yes	7	6	2	2
R:R:S83	R:R:Y316	7.63	1	No	Yes	7	7	2	1
R:R:D106	R:R:Y316	10.34	1	No	Yes	7	7	1	1
R:R:V107	R:R:Y184	3.79	0	No	Yes	6	8	1	2
R:R:C110	R:R:W285	5.22	1	No	Yes	6	8	1	1
R:R:F281	R:R:I114	3.77	1	Yes	No	9	8	2	2
R:R:I114	R:R:W285	15.27	1	No	Yes	8	8	2	1
R:R:F312	R:R:I178	5.02	1	Yes	No	6	6	1	2
R:R:S188	R:R:Y184	12.72	0	No	Yes	7	8	1	2
R:R:M292	R:R:V185	6.09	0	No	No	7	6	1	2
R:R:F289	R:R:S192	5.28	1	Yes	No	7	6	1	2
R:R:F193	R:R:F281	4.29	1	Yes	Yes	8	9	2	2
R:R:F193	R:R:W285	5.01	1	Yes	Yes	8	8	2	1
R:R:F193	R:R:F289	18.22	1	Yes	Yes	8	7	2	1
R:R:F281	R:R:W285	5.01	1	Yes	Yes	9	8	2	1
R:R:F289	R:R:W285	5.01	1	Yes	Yes	7	8	1	1
R:R:G315	R:R:W285	8.44	0	No	Yes	7	8	2	1
R:R:N318	R:R:W285	11.3	0	Yes	Yes	9	8	2	1
R:R:F288	R:R:V311	10.49	1	No	No	7	5	1	2
R:R:F288	R:R:F312	16.08	1	No	Yes	7	6	1	1
R:R:M292	R:R:P293	11.74	0	No	No	7	6	1	2
R:R:F312	R:R:Y316	5.16	1	Yes	Yes	6	7	1	1
R:R:W313	R:R:Y316	8.68	1	Yes	Yes	6	7	2	1
R:R:S158	R:R:V107	3.23	0	No	No	8	6	2	1
R:R:F308	R:R:F312	3.22	0	No	Yes	4	6	2	1
R:R:A189	R:R:F289	2.77	0	No	Yes	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
100.00	Consensus	alpha1_on_gp	Orthosteric Ligand	alpha1a_on_gp
100.00	Consensus	alpha1a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
100.00	Consensus	alpha1a_on_gp	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
90.91	Single	3NY8	ICI118-551	3NY8-β₂-ICI118-551
90.91	Single	4GBR	S-Carazolol	4GBR-β₂-S-Carazolol
90.91	Single	8XVK	Ambrisentan	8XVK-ET_A-Ambrisentan
90.91	Single	9CBM	Dexmedetomidine	9CBM-α_2a-Dexmedetomidine-Gi1/β1/γ2
90.91	Single	9PLN	N-(5-methylnaphthalen-1-yl)pyridin-4-amine	9PLN-α_2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
90.91	Single	9PLO	N-(5-methylnaphthalen-1-yl)pyridin-4-amine	9PLO-α_2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
90.91	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
90.91	Consensus	dopamine_off	Orthosteric Ligand	d2_off d3_off
90.00	Single	9MQJ	Isoquinuclidine	9MQJ-μ-Isoquinuclidine
83.33	Single	2RH1	S-Carazolol	2RH1-β₂-S-Carazolol
83.33	Single	2YCW	S-Carazolol	2YCW-β₁-S-Carazolol
83.33	Single	5D6L	S-Carazolol	5D6L-β₂-S-Carazolol
83.33	Single	5X7D	S-Carazolol	5X7D-β₂-S-Carazolol-Cmpd-15
83.33	Single	9MQK	Isoquinuclidine	9MQK-κ-Isoquinuclidine
83.33	Consensus	alpha_on_gp	Orthosteric Ligand	alpha1_on_gp alpha2_on_gp
83.33	Consensus	amine_off	Orthosteric Ligand	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
83.33	Consensus	amine_offon	Orthosteric Ligand	amine_off amine_on
83.33	Consensus	amine_offon_gp	Orthosteric Ligand	amine_on_gp amine_off
83.33	Consensus	amine_on	Orthosteric Ligand	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
83.33	Consensus	beta2_off	Orthosteric Ligand	2RH1-β₂-S-Carazolol 6PS3-β₂-S-Carvedilol 6PS5-β₂-S-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-ICI118-551 6PRZ-β₂-S-Alprenolol
83.33	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
83.33	Consensus	gi_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
81.82	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
81.82	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/β1/γ2
81.82	Single	6PS0	S-Carazolol	6PS0-β₂-S-Carazolol
81.82	Single	6PS4	ICI118-551	6PS4-β₂-ICI118-551
81.82	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/β1/γ2
81.82	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2
81.82	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/β1/γ2
81.82	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/β1/γ2
81.82	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
81.82	Single	8GGQ	Constrained Epinephrine	8GGQ-β₂-Constrained Epinephrine
81.82	Single	8GGX	Constrained Epinephrine	8GGX-β₂-Constrained Epinephrine
81.82	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
81.82	Single	8U02	L-Dopamine	8U02-D₂-L-Dopamine-Go/β1/γ2
81.82	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
81.82	Single	8YN3	Histamine	8YN3-H₂-Histamine-Gs/β1/γ2
81.82	Single	9MQI	Isoquinuclidine	9MQI-μ-Isoquinuclidine
81.82	Consensus	d3_on	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
81.82	Consensus	d3_on_gp	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
80.00	Single	8YN4	Histamine	8YN4-H₂-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
80.00	Single	9IXJ	Histamine	9IXJ-H₂-Histamine-Gs/β1/γ2
76.92	Single	2YDV	NECA	2YDV-A_2A-NECA
76.92	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
76.92	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
76.92	Single	5D5A	S-Carazolol	5D5A-β₂-S-Carazolol
76.92	Single	5D5B	S-Carazolol	5D5B-β₂-S-Carazolol
76.92	Single	5G53	NECA	5G53-A_2A-NECA-Gs
76.92	Single	7W6P	N-pyridin-4-ylisoquinolin-4-amine	7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
76.92	Single	7W7E	PubChem 164946676	7W7E-α_2a-PubChem 164946676-Go/β1/γ2
76.92	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
76.92	Single	9BJK	Naloxone	9BJK-μ-Naloxone-NAM
76.92	Consensus	amine_on_gp	Orthosteric Ligand	5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
76.92	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCW-β₁-S-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
75.00	Single	3NYA	S-Alprenolol	3NYA-β₂-S-Alprenolol
75.00	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
75.00	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
75.00	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
75.00	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
75.00	Single	6PS2	S-Alprenolol	6PS2-β₂-S-Alprenolol
75.00	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
75.00	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
75.00	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
75.00	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
75.00	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
75.00	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
75.00	Single	8GE3	Constrained Epinephrine	8GE3-β₂-Constrained Epinephrine-Gs/β1/γ2
75.00	Single	8GEC	Constrained Epinephrine	8GEC-β₂-Constrained Epinephrine-Gs/β1/γ2
75.00	Single	8GEE	Constrained Epinephrine	8GEE-β₂-Constrained Epinephrine-Gs/β1/γ2
75.00	Single	8GFV	Constrained Epinephrine	8GFV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8GFW	Constrained Epinephrine	8GFW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8GFX	Constrained Epinephrine	8GFX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8GFZ	Constrained Epinephrine	8GFZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8GG0	Constrained Epinephrine	8GG0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8GG1	Constrained Epinephrine	8GG1-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8GG3	Constrained Epinephrine	8GG3-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8GG4	Constrained Epinephrine	8GG4-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8GG6	Constrained Epinephrine	8GG6-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8GG9	Constrained Epinephrine	8GG9-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8GGI	Constrained Epinephrine	8GGI-β₂-Constrained Epinephrine
75.00	Single	8GGJ	Constrained Epinephrine	8GGJ-β₂-Constrained Epinephrine
75.00	Single	8GGK	Constrained Epinephrine	8GGK-β₂-Constrained Epinephrine
75.00	Single	8GGN	Constrained Epinephrine	8GGN-β₂-Constrained Epinephrine
75.00	Single	8GGO	Constrained Epinephrine	8GGO-β₂-Constrained Epinephrine
75.00	Single	8GGU	Constrained Epinephrine	8GGU-β₂-Constrained Epinephrine
75.00	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/β1/γ2
75.00	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
75.00	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
75.00	Single	8JXR	LSD	8JXR-D₁-LSD
75.00	Single	8UNQ	Constrained Epinephrine	8UNQ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8UNV	Constrained Epinephrine	8UNV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8UNY	Constrained Epinephrine	8UNY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8UNZ	Constrained Epinephrine	8UNZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8UO2	Constrained Epinephrine	8UO2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
75.00	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
75.00	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
75.00	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
75.00	Single	9PQD	(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole	9PQD-α_2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
75.00	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
75.00	Consensus	5ht1d_on_gp	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
75.00	Consensus	adrenergic_on	Orthosteric Ligand	alpha_on beta_on
75.00	Consensus	alpha2_on	Orthosteric Ligand	alpha2b_on
75.00	Consensus	alpha2_on_gp	Orthosteric Ligand	alpha2b_on_gp
75.00	Consensus	alpha2b_on	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
75.00	Consensus	alpha2b_on_gp	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
75.00	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
75.00	Consensus	dopamine_on	Orthosteric Ligand	d2_on d1_on d3_on d4_on d5_on
75.00	Consensus	dopamine_on_gp	Orthosteric Ligand	d2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
75.00	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
72.73	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
72.73	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
72.73	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
72.73	Single	8GGA	Constrained Epinephrine	8GGA-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
72.73	Single	8GGR	Constrained Epinephrine	8GGR-β₂-Constrained Epinephrine
72.73	Single	8GGZ	Constrained Epinephrine	8GGZ-β₂-Constrained Epinephrine
72.73	Single	8GH0	Constrained Epinephrine	8GH0-β₂-Constrained Epinephrine
72.73	Single	8TZQ	L-Dopamine	8TZQ-D₂-L-Dopamine-Go/β1/γ2
72.73	Single	8UNX	Constrained Epinephrine	8UNX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
72.73	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
72.73	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
72.73	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
72.73	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
72.73	Consensus	alpha2_off	Orthosteric Ligand	alpha2c_off
71.43	Single	3D4S	Timolol	3D4S-β₂-Timolol
71.43	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
71.43	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
71.43	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
71.43	Single	8FYE	4-F,5-MeO-PyrT	8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
71.43	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
71.43	Single	9MQL	Isoquinuclidine	9MQL-κ-Isoquinuclidine
71.43	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
71.43	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
71.43	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
71.43	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
70.00	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/β1/γ2
70.00	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/β1/γ2
70.00	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
70.00	Consensus	h2_on_gp	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
69.23	Single	5C1M	BU72	5C1M-μ-BU72
69.23	Single	5JQH	S-Carazolol	5JQH-β₂-S-Carazolol
69.23	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
69.23	Single	6PS3	S-Carvedilol	6PS3-β₂-S-Carvedilol
69.23	Single	6PS6	Timolol	6PS6-β₂-Timolol
69.23	Single	7BVQ	S-Carazolol	7BVQ-β₁-S-Carazolol
69.23	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/β1/γ2
69.23	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
69.23	Single	7XK9	Constrained Isoproterenol	7XK9-β₂-Constrained Isoproterenol-Na
69.23	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
69.23	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
69.23	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
69.23	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
69.23	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
69.23	Single	8GFY	Constrained Epinephrine	8GFY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23	Single	8GG2	Constrained Epinephrine	8GG2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23	Single	9K07	DSO-5a	9K07-BB₃-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
69.23	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
69.23	Consensus	5ht1_on_gp	Orthosteric Ligand	5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
69.23	Consensus	5ht1e_on_gp	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
69.23	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
69.23	Consensus	5ht5_on_gp	Orthosteric Ligand	5ht5a_on_gp
69.23	Consensus	5ht5a_on_gp	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
69.23	Consensus	adrenergic_off	Orthosteric Ligand	alpha_off beta_off
69.23	Consensus	adrenergic_on_gp	Orthosteric Ligand	alpha_on_gp beta_on_gp
69.23	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
69.23	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
69.23	Consensus	d4_on	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
69.23	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
69.23	Consensus	h1_off	Orthosteric Ligand	8X63-H₁-Mepyramine 3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole
69.23	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
69.23	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
66.67	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
66.67	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
66.67	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
66.67	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
66.67	Single	5X93	K-8794	5X93-ET_B-K-8794
66.67	Single	6PS5	S-Propranolol	6PS5-β₂-S-Propranolol
66.67	Single	6TPG	EMPA	6TPG-OX₂-EMPA
66.67	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
66.67	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
66.67	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/β1/γ2
66.67	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/β1/γ2
66.67	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
66.67	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/β1/γ2
66.67	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
66.67	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
66.67	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
66.67	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
66.67	Single	8GE1	Constrained Epinephrine	8GE1-β₂-Constrained Epinephrine-Gs/β1/γ2
66.67	Single	8GE4	Constrained Epinephrine	8GE4-β₂-Constrained Epinephrine-Gs/β1/γ2
66.67	Single	8GE6	Constrained Epinephrine	8GE6-β₂-Constrained Epinephrine-Gs/β1/γ2
66.67	Single	8GE7	Constrained Epinephrine	8GE7-β₂-Constrained Epinephrine-Gs/β1/γ2
66.67	Single	8GE8	Constrained Epinephrine	8GE8-β₂-Constrained Epinephrine-Gs/β1/γ2
66.67	Single	8GED	Constrained Epinephrine	8GED-β₂-Constrained Epinephrine-Gs/β1/γ2
66.67	Single	8GEF	Constrained Epinephrine	8GEF-β₂-Constrained Epinephrine-Gs/β1/γ2
66.67	Single	8GG5	Constrained Epinephrine	8GG5-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67	Single	8GG7	Constrained Epinephrine	8GG7-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67	Single	8GGL	Constrained Epinephrine	8GGL-β₂-Constrained Epinephrine
66.67	Single	8GGM	Constrained Epinephrine	8GGM-β₂-Constrained Epinephrine
66.67	Single	8GGP	Constrained Epinephrine	8GGP-β₂-Constrained Epinephrine
66.67	Single	8GGS	Constrained Epinephrine	8GGS-β₂-Constrained Epinephrine
66.67	Single	8GGT	Constrained Epinephrine	8GGT-β₂-Constrained Epinephrine
66.67	Single	8GGV	Constrained Epinephrine	8GGV-β₂-Constrained Epinephrine
66.67	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
66.67	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/β1/γ2
66.67	Single	8S2T	Isoprenaline	8S2T-β₁-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
66.67	Single	8UNL	Constrained Epinephrine	8UNL-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67	Single	8UNM	Constrained Epinephrine	8UNM-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67	Single	8UNO	Constrained Epinephrine	8UNO-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67	Single	8UNW	Constrained Epinephrine	8UNW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67	Single	8UO0	Constrained Epinephrine	8UO0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
66.67	Single	9AS5	Mescaline	9AS5-5-HT_2A-Mescaline
66.67	Single	9AS6	Mescaline	9AS6-5-HT_2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
66.67	Single	9CBL	Epinephrine	9CBL-α_2a-Epinephrine-Gi1/β1/γ2
66.67	Single	9CGJ	C6-Quino	9CGJ-δ-C6-Quino-Gi1/β1/γ2
66.67	Consensus	5ht_on_gp	Orthosteric Ligand	5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
66.67	Consensus	endothelin_off	Orthosteric Ligand	etb_off
66.67	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
64.29	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
64.29	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
64.29	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
64.29	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
64.29	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
64.29	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
64.29	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
64.29	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/β1/γ2
64.29	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/β1/γ2
64.29	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
64.29	Single	8E0G	BU72	8E0G-μ-BU72
64.29	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
64.29	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
64.29	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
64.29	Single	8XVL	Zibotentan	8XVL-ET_A-Zibotentan
64.29	Single	9IJD	Carazolol	9IJD-β₃-Carazolol-chim(NtGi1-Gs)/β1/γ2
64.29	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht1_off
64.29	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
64.29	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
64.29	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
64.29	Consensus	d4_on_gp	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
64.29	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
64.29	Consensus	gi_5ht	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E32-5-HT_1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT₄-Serotonin-Gi1/β1/γ2 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
64.29	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
64.29	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
64.29	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
64.29	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
64.29	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
64.29	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
63.64	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
63.64	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2
63.64	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
63.64	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/β1/γ2
63.64	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/β1/γ2
63.64	Single	8GGY	Constrained Epinephrine	8GGY-β₂-Constrained Epinephrine
63.64	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
63.64	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
63.64	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
63.64	Single	9IJE	Epinephrine	9IJE-β₃-Epinephrine-chim(NtGi1-Gs)/β1/γ2
63.64	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
63.64	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
63.64	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
62.50	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
62.50	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
62.50	Single	6PT3	DPI-287	6PT3-δ-DPI-287
62.50	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
62.50	Single	9CGK	C5-Quino	9CGK-δ-C5-Quino-Gi1/β1/γ2
61.54	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
61.54	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
61.54	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
61.54	Single	4U16	N-Methyl-Scopolamine	4U16-M₃-N-Methyl-Scopolamine
61.54	Single	5YC8	N-Methyl-Scopolamine	5YC8-M₂-N-Methyl-Scopolamine
61.54	Single	5ZK8	N-Methyl-Scopolamine	5ZK8-M₂-N-Methyl-Scopolamine
61.54	Single	5ZKC	N-Methyl-Scopolamine	5ZKC-M₂-N-Methyl-Scopolamine
61.54	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
61.54	Single	6PRZ	S-Alprenolol	6PRZ-β₂-S-Alprenolol
61.54	Single	6PS1	Timolol	6PS1-β₂-Timolol
61.54	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
61.54	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
61.54	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/β1/γ2
61.54	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
61.54	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
61.54	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
61.54	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/β1/γ2
61.54	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
61.54	Single	8FY8	5-MeO-DMT	8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1
61.54	Single	8GE9	Constrained Epinephrine	8GE9-β₂-Constrained Epinephrine-Gs/β1/γ2
61.54	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
61.54	Single	8JD0	NAM563	8JD0-mGlu2; mGlu3-Glutamate-NAM563
61.54	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
61.54	Single	8PJK	ST171	8PJK-5-HT_1A-ST171-Gi1/β1/γ1
61.54	Single	8T1W	CVN424	8T1W-GPR6-CVN424
61.54	Single	8UGY	Mianserin	8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1
61.54	Single	8UH3	Setiptiline	8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
61.54	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54	Single	8VVG	GB18	8VVG-κ-GB18-Gi1/β1/γ2
61.54	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
61.54	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
61.54	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
61.54	Single	9JEA	Atropine	9JEA-M₁-Atropine
61.54	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
61.54	Consensus	5ht5a_on	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
61.54	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
61.54	Consensus	5ht7_on_gp	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
61.54	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
61.54	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
61.54	Consensus	histamine_off	Orthosteric Ligand	h1_off
60.00	Single	4LDE	BI167107	4LDE-β₂-BI167107
60.00	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
60.00	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
60.00	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
60.00	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
60.00	Single	6OY9	All-trans-Retinal	6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
60.00	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
60.00	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
60.00	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
60.00	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
60.00	Single	8FYT	LSD	8FYT-5-HT_1A-LSD-Gi1/β1/γ1
60.00	Single	8IWM	2-Phenylethylamine	8IWM-TA9-2-Phenylethylamine
60.00	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
60.00	Single	8WC5	Tetramethylammonium Ion	8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
60.00	Single	9CHU	Noradrenaline	9CHU-β₂-Noradrenaline
60.00	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
60.00	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
60.00	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
60.00	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
60.00	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
60.00	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
60.00	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
60.00	Consensus	gs_histamine	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
60.00	Consensus	h2_on	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
60.00	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
60.00	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
58.82	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
58.82	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
58.82	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
58.82	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
58.82	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
58.33	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
58.33	Single	6AKX	A4R	6AKX-CCR5-A4R
58.33	Single	6B73	MP1104	6B73-κ-MP1104
58.33	Single	6OBA	S-Alprenolol	6OBA-β₂-S-Alprenolol-GTPL11074
58.33	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
58.33	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/β1/γ2
58.33	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2
58.33	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
58.33	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
58.33	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/β1/γ1
58.33	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
58.33	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
58.33	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
58.33	Single	7T96	Acetylcholine	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
58.33	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/β1/γ2
58.33	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2
58.33	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/β1/γ2
58.33	Single	8FYX	Buspirone	8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1
58.33	Single	8GGC	Constrained Epinephrine	8GGC-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33	Single	8GGW	Constrained Epinephrine	8GGW-β₂-Constrained Epinephrine
58.33	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/β1/γ2
58.33	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
58.33	Single	8UNS	Constrained Epinephrine	8UNS-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33	Single	8UNT	Constrained Epinephrine	8UNT-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33	Single	8YNA	Immepip	8YNA-H₄-Immepip-Gi1/β1/γ2
58.33	Single	8YUT	Amthamine	8YUT-H₂-Amthamine-Gs/β1/γ2
58.33	Single	9LRB	Histamine	9LRB-H₁-Histamine-Gs/β1/γ2
58.33	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
58.33	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
58.33	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
58.33	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
58.33	Consensus	gs_5ht	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2 7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2 7XT8-5-HT₄-Serotonin-Gs/β1/γ2
58.33	Consensus	h1_on_gp	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
58.33	Consensus	histamine_on	Orthosteric Ligand	h1_on h2_on h3_on h4_on
58.33	Consensus	histamine_on_gp	Orthosteric Ligand	h1_on_gp h2_on_gp h3_on_gp h4_on_gp
58.33	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
58.33	Consensus	m2_on_gp	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
57.14	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
57.14	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
57.14	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
57.14	Single	5WQC	EMPA	5WQC-OX₂-EMPA
57.14	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
57.14	Single	6E67	BI167107	6E67-β₂-BI167107-Gs(CT)
57.14	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
57.14	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
57.14	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/β1/γ2
57.14	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
57.14	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/β1/γ2
57.14	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
57.14	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/β1/γ2
57.14	Single	8ZMF	A1L10	8ZMF-5-HT_2C-A1L10
57.14	Single	9DYD	Asenapine	9DYD-5-HT_1A-Asenapine-Go/β1/γ2
57.14	Single	9DYF	Asenapine	9DYF-5-HT_1A-Asenapine-Gi1/β1/γ2
57.14	Single	9EE8	Adenosine	9EE8-A_2A-Adenosine-Gs/β1/γ2
57.14	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go/β1/γ2
57.14	Single	9F34	FOB02-04A	9F34-D₃-FOB02-04A-Go/β1/γ2
57.14	Single	9I52	A1IZU	9I52-D₁-A1IZU-Gs/β1/γ2
57.14	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
57.14	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
57.14	Consensus	m2_off	Orthosteric Ligand	5ZKC-M₂-N-Methyl-Scopolamine 5ZK3-M₂-3-quinuclidinyl-benzilate 5ZKB-M₂-AF-DX 384
57.14	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
57.14	Consensus	m3_on_gp	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
56.25	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
56.25	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
56.25	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
56.25	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
56.25	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
56.25	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
56.25	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
56.25	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
56.25	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
56.25	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
56.25	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
54.55	Single	8GH1	Constrained Epinephrine	8GH1-β₂-Constrained Epinephrine
54.55	Single	8IW7	2-Phenylethylamine	8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
54.55	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
54.55	Single	8YN9	Histamine	8YN9-H₄-Histamine-Gi1/β1/γ2
54.55	Single	8YUU	Histamine	8YUU-H₃-Histamine-Gi1/β1/γ1
54.55	Single	9LRC	Histamine	9LRC-H₄-Histamine
54.55	Single	9LRE	Histamine	9LRE-H₄-Histamine-Gi1/β1/γ2
54.55	Consensus	5ht2_on	Orthosteric Ligand	5ht2b_on
54.55	Consensus	5ht2b_on	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
54.55	Consensus	h3_on	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
54.55	Consensus	h3_on_gp	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
53.85	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
53.85	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
53.85	Single	3UZC	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	3UZC-A_2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
53.85	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
53.85	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
53.85	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
53.85	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
53.85	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
53.85	Single	6VI4	JDTic	6VI4-κ-JDTic
53.85	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
53.85	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
53.85	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
53.85	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
53.85	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
53.85	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
53.85	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/β1/γ2
53.85	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
53.85	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
53.85	Single	8GEA	Constrained Epinephrine	8GEA-β₂-Constrained Epinephrine-Gs/β1/γ2
53.85	Single	8GG8	Constrained Epinephrine	8GG8-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2
53.85	Single	8PM2	DMCH	8PM2-TA7-DMCH-Gs/β1/γ2
53.85	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
53.85	Single	8UO1	Constrained Epinephrine	8UO1-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
53.85	Single	8V6U	PubChem 171392456	8V6U-5-HT_2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
53.85	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2
53.85	Single	8Y01	Retinal	8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
53.85	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
53.85	Single	8Y53	MK5046	8Y53-BB₃-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
53.85	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
53.85	Single	8ZMG	Pimavanserin	8ZMG-5-HT_2A-Pimavanserin
53.85	Single	9ARX	Serotonin	9ARX-5-HT_2A-Serotonin
53.85	Single	9AS3	LSD	9AS3-5-HT_2A-LSD
53.85	Single	9AS4	LSD	9AS4-5-HT_2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
53.85	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
53.85	Single	9LRD	Histamine	9LRD-H₁-Histamine-Gi1/β1/γ2
53.85	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
53.33	Single	3P0G	BI167107	3P0G-β₂-BI167107
53.33	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/β1/γ2
53.33	Single	4DJH	JDTic	4DJH-κ-JDTic
53.33	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
53.33	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
53.33	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
53.33	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/β1/γ2
53.33	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
53.33	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2
53.33	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
53.33	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/β1/γ2
53.33	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
53.33	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
53.33	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
53.33	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
53.33	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/β1/γ2
53.33	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
53.33	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/β1/γ2
53.33	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
53.33	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
53.33	Single	8VVF	JDTic	8VVF-κ-JDTic-Gi1/β1/γ2
53.33	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
53.33	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
53.33	Consensus	a2_on	Orthosteric Ligand	a2b_on
53.33	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
53.33	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
53.33	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
53.33	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
53.33	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
53.33	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
53.33	Consensus	h4_on_gp	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
53.33	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
53.33	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl-Scopolamine 5ZHP-M₃-PubChem 134828589
53.33	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
52.94	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
52.94	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
52.63	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
50.00	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
50.00	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
50.00	Single	2G87	All-trans-Retinal	2G87-Rhodopsin-All-trans-Retinal
50.00	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
50.00	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
50.00	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
50.00	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
50.00	Single	3PXO	All-trans-Retinal	3PXO-Rhodopsin-All-trans-Retinal
50.00	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
50.00	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
50.00	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
50.00	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
50.00	Single	4QKX	35V	4QKX-β₂-35V
50.00	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
50.00	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
50.00	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
50.00	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
50.00	Single	5DYS	All-trans-Retinal	5DYS-Rhodopsin-All-trans-Retinal
50.00	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
50.00	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
50.00	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
50.00	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
50.00	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
50.00	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
50.00	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
50.00	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
50.00	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
50.00	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00	Single	7BU7	BI167107	7BU7-β₁-BI167107
50.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
50.00	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
50.00	Single	7EPE	NAM563	7EPE-mGlu2; mGlu2-NAM563
50.00	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
50.00	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
50.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
50.00	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/β1/γ2
50.00	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/β1/γ2
50.00	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
50.00	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
50.00	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
50.00	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
50.00	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/β1/γ2
50.00	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
50.00	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/β1/γ2
50.00	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
50.00	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
50.00	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
50.00	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
50.00	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/β1/γ2
50.00	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
50.00	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-Gi1/β1/γ1
50.00	Single	8UO3	Constrained Epinephrine	8UO3-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
50.00	Single	8YN5	Histamine	8YN5-H₃-Histamine-Gi1/β1/γ2
50.00	Single	8YN6	Imetit	8YN6-H₃-Imetit-Gi1/β1/γ2
50.00	Single	8YN7	Immethridine	8YN7-H₃-Immethridine-Go/β1/γ2
50.00	Single	8YN8	Proxyfan	8YN8-H₃-Proxyfan-Go/β1/γ2
50.00	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00	Single	9AS1	DMT	9AS1-5-HT_2A-DMT
50.00	Single	9AS2	DMT	9AS2-5-HT_2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00	Single	9D61	JDTic	9D61-κ-JDTic-Gi1/β1/γ2
50.00	Single	9EBI	Piclidenoson	9EBI-A_3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
50.00	Single	9KFJ	PubChem 138319674	9KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
50.00	Single	9M4T	Silodosin	9M4T-Alpha1A-Silodosin
50.00	Consensus	5ht1a_on	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
50.00	Consensus	5ht1a_on_gp	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
50.00	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide
50.00	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
50.00	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
50.00	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
50.00	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
50.00	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
50.00	Consensus	gi_histamine	Orthosteric Ligand	8JXX-H₄-Clobenpropit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8YUU-H₃-Histamine-Gi1/β1/γ1 8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2
50.00	Consensus	gi_orexin	Orthosteric Ligand	7SQO-OX₂-TAK-925-Gi1/β1/γ2
50.00	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
50.00	Consensus	h4_on	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
50.00	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
50.00	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
50.00	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
50.00	Consensus	muscarinic_on_gp	Orthosteric Ligand	m2_on_gp m3_on_gp m4_on_gp m1_on_gp
47.37	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
47.37	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
47.37	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
47.06	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
47.06	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
47.06	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/β1/γ2
47.06	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
47.06	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
47.06	Single	7EZC	UKA	7EZC-A_2A-UKA
47.06	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
47.06	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
47.06	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
47.06	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/β1/γ2
47.06	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
47.06	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
47.06	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
47.06	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.06	Single	8XVJ	Macitentan	8XVJ-ET_A-Macitentan
47.06	Single	9AS0	2-bromo-LSD	9AS0-5-HT_2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
47.06	Single	9DYE	Buspirone	9DYE-5-HT_1A-Buspirone-Go/β1/γ2
47.06	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
47.06	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
46.67	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
46.67	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
46.67	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
46.67	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
46.67	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
46.67	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
46.67	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
46.67	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
46.67	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
46.67	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
46.67	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
46.67	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
46.67	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
46.67	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
46.67	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-MIPS521-Gi2/β1/γ2
46.67	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
46.67	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/β1/γ2
46.67	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
46.67	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
46.67	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
46.67	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
46.67	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
46.67	Single	9ARY	Serotonin	9ARY-5-HT_2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
46.67	Single	9ARZ	2-bromo-LSD	9ARZ-5-HT_2A-2-bromo-LSD
46.67	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
46.67	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
46.67	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
46.67	Single	9HAP	Tolvaptan	9HAP-V₂-Tolvaptan
46.67	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
46.67	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
46.15	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
46.15	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
46.15	Single	5WS3	EMPA	5WS3-OX₂-EMPA
46.15	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
46.15	Single	6NWE	Octyl-Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
46.15	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
46.15	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
46.15	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
46.15	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
46.15	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
46.15	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
46.15	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
46.15	Single	8IW4	Spermidine	8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
46.15	Single	8IWE	Spermidine	8IWE-TA9-Spermidine
46.15	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
46.15	Single	8Y0H	VUF11418	8Y0H-CXCR3-VUF11418
46.15	Single	8Y0N	VUF11418	8Y0N-CXCR3-VUF11418-Go/β1/γ2
46.15	Single	8YUV	Immepip	8YUV-H₃-Immepip-Gi1/β1/γ2
46.15	Single	9EBH	Adenosine	9EBH-A_3A-Adenosine-Gi1/β1/γ2
46.15	Single	9EEA	Adenosine	9EEA-A_2A-Adenosine-Gs/β1/γ2
46.15	Single	9J5V	CpY	9J5V-LPA₁-CpY-Gi1/β1/γ2
46.15	Consensus	5ht2_on_gp	Orthosteric Ligand	5ht2b_on_gp
46.15	Consensus	5ht2b_on_gp	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
46.15	Consensus	ox1_off	Orthosteric Ligand	6TP6-OX₁-Filorexant 6TP4-OX₁-ACT-462206 6V9S-OX₁-GTPL11403 6TOT-OX₁-Lemborexant 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant 6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na
46.15	Consensus	ox2_off	Orthosteric Ligand	5WQC-OX₂-EMPA 6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant 6TPJ-OX₂-Suvorexant
46.15	Consensus	rhodopsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
46.15	Consensus	sensory_offon	Orthosteric Ligand	sensory_off sensory_on
46.15	Consensus	sensory_offon_gp	Orthosteric Ligand	sensory_on_gp sensory_on
45.45	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
45.45	Single	8GEI	Constrained Epinephrine	8GEI-β₂-Constrained Epinephrine-Gs/β1/γ2
45.45	Consensus	opsins_on	Orthosteric Ligand	rhodopsin_on opsin1lw_on
45.45	Consensus	sensory_on	Orthosteric Ligand	opsins_on
45.00	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
45.00	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
44.44	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
44.44	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
44.44	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
44.44	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
44.44	Single	8Y72	Peptide	8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
44.44	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
44.44	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
44.44	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
43.75	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
43.75	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
43.75	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
43.75	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/β1/γ2
43.75	Single	6E59	L-760735	6E59-NK₁-L-760735
43.75	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
43.75	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
43.75	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
43.75	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/β1/γ2
43.75	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
43.75	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
43.75	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/β1/γ2
43.75	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
43.75	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
43.75	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
43.75	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2
43.75	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
43.75	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
43.75	Single	9AS9	RS130-180	9AS9-5-HT_2A-RS130-180
43.75	Single	9ASA	RS130-180	9ASA-5-HT_2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
43.75	Single	9I54	A1IZV	9I54-D₁-A1IZV-Gs/β1/γ2
43.75	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
43.75	Consensus	m1_on_gp	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
42.86	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
42.86	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
42.86	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
42.86	Single	6IQL	L745870	6IQL-D₄-L745870
42.86	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
42.86	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
42.86	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
42.86	Single	7UL3	Famotidine	7UL3-H₂-Famotidine
42.86	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
42.86	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
42.86	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
42.86	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/β1/γ2
42.86	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
42.86	Single	8K9K	Damgo	8K9K-μ-Damgo-Gi3/β1/γ1
42.86	Single	8RLN	LUF5834	8RLN-A_2A-LUF5834
42.86	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
42.86	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
42.86	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
42.86	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
42.86	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
42.86	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
42.86	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
42.86	Consensus	sensory_off	Orthosteric Ligand	opsins_off
42.11	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
42.11	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
42.11	Single	9BUY	LM189	9BUY-β₂-LM189-Gi1/β1/γ2
42.11	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
41.67	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
41.67	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
41.67	Single	3PQR	All-trans-Retinal	3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
41.67	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
41.67	Single	6FUF	All-trans-Retinal	6FUF-Rhodopsin-All-trans-Retinal-Go
41.67	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
41.67	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
41.67	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
41.67	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.67	Single	8GGE	Constrained Epinephrine	8GGE-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.67	Single	8GGF	Constrained Epinephrine	8GGF-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
41.67	Single	8ITF	DMCHA	8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
41.67	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/β1/γ2
41.67	Consensus	opsins_on_gp	Orthosteric Ligand	rhodopsin_on_gp opsin1lw_on_gp
41.67	Consensus	rhodopsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
41.67	Consensus	sensory_on_gp	Orthosteric Ligand	opsins_on_gp
41.18	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
41.18	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
41.18	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
41.18	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
41.18	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
41.18	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
41.18	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
41.18	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
41.18	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
41.18	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
41.18	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
41.18	Single	8JD3	JNJ-40411813	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
41.18	Single	8JWY	2-118	8JWY-A_2A-2-118
41.18	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
41.18	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
41.18	Single	9GL2	Befiradol	9GL2-5-HT_1A-Befiradol-Gs/β1/γ2
41.18	Single	9M4Q	Doxazosin	9M4Q-Alpha1A-Doxazosin
41.18	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
41.18	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
41.18	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
41.18	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
41.18	Consensus	orexin_on	Orthosteric Ligand	ox2_on
41.18	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
41.18	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
40.91	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
40.00	Single	4A4M	All-trans-Retinal	4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
40.00	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
40.00	Single	5DHG	C-35	5DHG-NOP-C-35
40.00	Single	5EN0	All-trans-Retinal	5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
40.00	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
40.00	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
40.00	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/β1/γ2
40.00	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
40.00	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
40.00	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.00	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
40.00	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/β1/γ2
40.00	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
40.00	Single	8UWL	Lisuride	8UWL-5-HT_2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
40.00	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
40.00	Single	9BQJ	RO76	9BQJ-μ-RO76-Gi1/β1/γ2
40.00	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
40.00	Consensus	a3_on	Orthosteric Ligand	a3a_on
40.00	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
40.00	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
40.00	Consensus	blt_on	Orthosteric Ligand	blt1_on
40.00	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
40.00	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
40.00	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
40.00	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
39.13	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
38.89	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
38.89	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
38.89	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
38.89	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
38.89	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.89	Single	9M54	Neuropeptide VF	9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
38.89	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
38.89	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
38.89	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
38.46	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
38.46	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
38.46	Single	6HLL	CP99994	6HLL-NK₁-CP99994
38.46	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
38.46	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
38.46	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
38.46	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-LY2119620-Gi1/β1/γ2
38.46	Single	8UO4	Constrained Epinephrine	8UO4-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
38.46	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
38.46	Single	8YN2	Histamine	8YN2-H₁-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.46	Single	9AS7	Psilocin	9AS7-5-HT_2A-Psilocin
38.46	Single	9EPR	Retinal	9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
38.46	Single	9L3Z	LRH7-C2	9L3Z-CML1-LRH7-C2
38.10	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
38.10	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
37.50	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
37.50	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
37.50	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
37.50	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
37.50	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
37.50	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
37.50	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
37.50	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
37.50	Single	7W41	PD176252	7W41-BB₂-PD176252
37.50	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/β1/γ2
37.50	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
37.50	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
37.50	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
37.50	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
37.50	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
37.50	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
37.50	Single	8XYK	VUF10661	8XYK-CXCR3-VUF10661-Go/β1/γ2
37.50	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
37.50	Single	8ZRK	GSK-1292263	8ZRK-GPR119-GSK-1292263-Gs/β1/γ2
37.50	Single	9KDF	RES-701-3	9KDF-ET_B-RES-701-3
37.50	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
37.50	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
37.50	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
37.50	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
37.50	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
37.50	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
36.84	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
36.84	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
36.84	Single	9M0R	Neuropeptide VF	9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
36.84	Single	9MD1	Buspirone	9MD1-5-HT_1A-Buspirone-Gz/β1/γ2
36.84	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
35.71	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
35.71	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
35.71	Single	3VGA	ZM-241385	3VGA-A_2A-ZM-241385-Antibody
35.71	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
35.71	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
35.71	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
35.71	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
35.71	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
35.71	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
35.71	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
35.71	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
35.71	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
35.71	Single	8A6C	All-trans-Retinal	8A6C-Rhodopsin-All-trans-Retinal
35.71	Single	8A6D	All-trans-Retinal	8A6D-Rhodopsin-All-trans-Retinal
35.71	Single	8A6E	All-trans-Retinal	8A6E-Rhodopsin-All-trans-Retinal
35.71	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
35.71	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
35.71	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
35.71	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
35.71	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
35.71	Single	9H2X	A1IR1	9H2X-A_2A-A1IR1-Na
35.71	Single	9K6L	SA0	9K6L-TAS2R16-SA0-Gi2/β1/γ2
35.71	Single	9KPE	SA0	9KPE-TAS2R16-SA0-Gi1/β1/γ2
35.71	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
35.71	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
35.29	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
35.29	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
35.29	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
35.29	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
35.29	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
35.29	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
35.29	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
35.29	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
35.29	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
35.29	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
35.29	Single	8WU1	PubChem 119025665	8WU1-CB₁-PubChem 119025665-Arrestin2
35.29	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
35.29	Single	8X0F	VU0424465	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
35.29	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
35.29	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
35.29	Single	8XZI	CMF-019	8XZI-Apelin-CMF-019-Gi1/β1/γ2
35.29	Single	8Y73	Peptide	8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
35.29	Single	9B65	KCA	9B65-CB₁-KCA-Gi1/β1/γ2
35.29	Single	9IK9	SST analogue	9IK9-SST1-SST analogue-Gi1/β1/γ2
35.29	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
35.29	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
35.00	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
35.00	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
35.00	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
34.78	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
34.62	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
34.62	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
34.62	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
34.62	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
34.62	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33	Single	2HPY	All-trans-Retinal	2HPY-Rhodopsin-All-trans-Retinal
33.33	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
33.33	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
33.33	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
33.33	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
33.33	Single	6AQF	ZM-241385	6AQF-A_2A-ZM-241385
33.33	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
33.33	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
33.33	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
33.33	Single	6TPK	Retosiban	6TPK-OT-Retosiban
33.33	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
33.33	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
33.33	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
33.33	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
33.33	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
33.33	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
33.33	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
33.33	Single	7F61	PF-03654746	7F61-H₃-PF-03654746
33.33	Single	7MTB	All-trans-Retinal	7MTB-Rhodopsin-All-trans-Retinal-GRK1
33.33	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
33.33	Single	7T32	ZM-241385	7T32-A_2A-ZM-241385
33.33	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
33.33	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/β1/γ2
33.33	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33	Single	8GUR	CP55,940	8GUR-CB₂-CP55,940-Gi1/β1/γ2
33.33	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
33.33	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
33.33	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
33.33	Single	8XOF	Lys05	8XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	8XYI	VUF10661	8XYI-CXCR3-VUF10661
33.33	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	9EE9	Adenosine	9EE9-A_2A-Adenosine-Gs/β1/γ2
33.33	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
33.33	Single	9JH3	CMF-019	9JH3-Apelin-CMF-019-Gi1/β1/γ2
33.33	Consensus	a2_off	Orthosteric Ligand	a2a_off
33.33	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PSB-36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-Chromone 5d-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
33.33	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
33.33	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
33.33	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
33.33	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
33.33	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
33.33	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
33.33	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
33.33	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
33.33	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
33.33	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
33.33	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
32.00	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
32.00	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
32.00	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
32.00	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
31.82	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
31.82	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
31.82	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
31.82	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.82	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.82	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
31.82	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
31.82	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
31.58	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
31.58	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
31.58	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
31.58	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
31.58	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
31.58	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/β1/γ2
31.58	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
31.58	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
31.58	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
31.58	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
31.58	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58	Single	8XGS	Metastin	8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
31.58	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58	Single	8ZWG	JR14a	8ZWG-C3a_B-JR14a-Gi1/β1/γ2
31.58	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
31.58	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
31.58	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
31.25	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
31.25	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
31.25	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
31.25	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
31.25	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
31.25	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
31.25	Single	5UIG	Cmpd-1	5UIG-A_2A-Cmpd-1
31.25	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
31.25	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
31.25	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
31.25	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
31.25	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
31.25	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
31.25	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
31.25	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
31.25	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
31.25	Single	9H37	A1IR0	9H37-A_2A-A1IR0-Na
31.25	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
31.25	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
30.77	Single	5WKT	Octyl-Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
30.77	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
30.77	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
30.77	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
30.77	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
30.77	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
30.77	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/β1/γ2
30.77	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/β1/γ2
30.77	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
30.77	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
30.77	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
30.77	Consensus	ffa3_on_gp	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
30.77	Consensus	gi_opsins	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
30.77	Consensus	gi_sensory	Orthosteric Ligand	gi_opsins
30.77	Consensus	opsin1lw_on	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
30.77	Consensus	opsin1lw_on_gp	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
30.43	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
30.43	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
30.43	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
30.43	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
30.43	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
30.43	Single	8ZBI	Somatostatin-14	8ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
30.43	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
30.43	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
30.43	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
30.43	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
30.43	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
30.43	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
30.43	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
30.00	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
30.00	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
30.00	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
30.00	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
30.00	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
30.00	Single	9IPV	JR14a	9IPV-C3a_B-JR14a-Gi1/β1/γ2
30.00	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
30.00	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
30.00	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.00	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
29.63	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
29.41	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
29.41	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
29.41	Single	5N2R	PSB-36	5N2R-A_2A-PSB-36-Na
29.41	Single	5N2S	PSB36	5N2S-A₁-PSB36
29.41	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
29.41	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
29.41	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
29.41	Single	7C4S	S1P	7C4S-S1P₃-S1P
29.41	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
29.41	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
29.41	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
29.41	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
29.41	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
29.41	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
29.41	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
29.41	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
29.41	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/β1/γ2
29.41	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
29.41	Single	8TH4	Losartan	8TH4-AT₁-Losartan-AT118-L Nanobody
29.41	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
29.41	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
29.41	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
29.41	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
29.41	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
29.41	Single	9EHS	LUF7602	9EHS-A_3A-LUF7602
29.41	Single	9HC0	4YI	9HC0-mGlu₅-4YI
29.41	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
29.41	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
29.41	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
29.41	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
29.41	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
29.17	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
29.17	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.17	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57	Single	3AYM	All-trans-Retinal	3AYM-Rhodopsin-All-trans-Retinal
28.57	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
28.57	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
28.57	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
28.57	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
28.57	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.57	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
28.57	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
28.57	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
28.57	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
28.57	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
28.57	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
28.57	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
28.57	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
28.57	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
28.57	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
28.57	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57	Single	8YKW	Succinic acid	8YKW-Succinate-Succinic acid-Gi1/β1/γ1
28.57	Single	8ZBJ	Somatostatin-14	8ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
28.57	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
28.57	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
28.57	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.57	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
28.57	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.57	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
28.57	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
28.57	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
28.57	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
28.57	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
28.00	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
28.00	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.00	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
28.00	Single	9KFK	Relaxin-3	9KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
28.00	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
27.78	Single	5XR8	AM841	5XR8-CB₁-AM841
27.78	Single	5XRA	AM11542	5XRA-CB₁-AM11542
27.78	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
27.78	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
27.78	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
27.78	Single	7P2L	4YI	7P2L-mGlu₅-4YI
27.78	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
27.78	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
27.78	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
27.78	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
27.78	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
27.78	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
27.78	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
27.78	Single	8JD5	JNJ-40411813; ADX88178	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
27.78	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
27.78	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
27.78	Single	8ZWF	JR14a	8ZWF-C3a_B-JR14a
27.78	Single	9JMC	DS-3801b	9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
27.78	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
27.78	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
27.78	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
27.27	Single	5MZP	Caffeine	5MZP-A_2A-Caffeine-Na
27.27	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
27.27	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
27.27	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
27.27	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
27.27	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
27.27	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
27.27	Single	8GEJ	Constrained Epinephrine	8GEJ-β₂-Constrained Epinephrine-Gs/β1/γ2
27.27	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
27.27	Single	8WCB	Cyclohexylammonium Ion	8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27	Single	8WCC	Cyclohexylammonium Ion	8WCC-TA1-Cyclohexylammonium Ion
27.27	Single	9IK8	SST analogue	9IK8-SST1-SST analogue-Gi1/β1/γ2
27.27	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
27.27	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
27.27	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
26.92	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
26.92	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
26.92	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
26.92	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
26.67	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
26.67	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
26.67	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
26.67	Single	5K2D	ZM-241385	5K2D-A_2A-ZM-241385-Na
26.67	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
26.67	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
26.67	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
26.67	Single	6JZH	ZM-241385	6JZH-A_2A-ZM-241385-Na
26.67	Single	6PS7	ZM-241385	6PS7-A_2A-ZM-241385-Na
26.67	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
26.67	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
26.67	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
26.67	Single	7TUZ	7-alpha,25-dihydroxycholesterol	7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
26.67	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
26.67	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
26.67	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
26.67	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
26.67	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
26.67	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
26.67	Single	8RW0	Istradefylline	8RW0-A_2A-Istradefylline-Na
26.67	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67	Single	8WOG	Succinic acid	8WOG-Succinate-Succinic acid-Gi1/β1/γ2
26.67	Single	8YKX	Maleic acid	8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.67	Consensus	angiotensin_off	Orthosteric Ligand	at1_off
26.67	Consensus	gi_succinate	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.67	Consensus	succinate_on	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.67	Consensus	succinate_on_gp	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.32	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
26.32	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
26.32	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
26.32	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/β1/γ2
26.32	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
26.32	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
26.32	Single	8XJN	Cloprosetnol	8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32	Single	9DGI	Z8526711350	9DGI-CB₁-Z8526711350
26.32	Single	9GGG	I-BOP	9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
26.32	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
26.32	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
26.32	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
26.32	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
26.32	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
26.32	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
26.32	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
26.09	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
26.09	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.09	Single	9M1O	Morphine-Modulating Neuropeptide B	9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
26.09	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
26.09	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
25.93	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
25.93	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
25.93	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
25.93	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
25.93	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
25.93	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
25.93	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
25.93	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
25.00	Single	3REY	XAC	3REY-A_2A-XAC
25.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
25.00	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
25.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
25.00	Single	5IU4	ZM-241385	5IU4-A_2A-ZM-241385-Na
25.00	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
25.00	Single	5K2C	ZM-241385	5K2C-A_2A-ZM-241385-Na
25.00	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
25.00	Single	5NLX	ZM-241385	5NLX-A_2A-ZM-241385-Na
25.00	Single	5NM4	ZM-241385	5NM4-A_2A-ZM-241385-Na
25.00	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
25.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
25.00	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
25.00	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
25.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
25.00	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
25.00	Single	6MH8	ZM-241385	6MH8-A_2A-ZM-241385
25.00	Single	6ZDV	Chromone 5d	6ZDV-A_2A-Chromone 5d-Na
25.00	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
25.00	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
25.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
25.00	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
25.00	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
25.00	Single	8GAG	PubChem 170838490	8GAG-CB₁-PubChem 170838490-Gi1/β1/γ2
25.00	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
25.00	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
25.00	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
25.00	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
25.00	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
25.00	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
25.00	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/β1/γ2
25.00	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
25.00	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
25.00	Single	8K9L	Damgo	8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
25.00	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
25.00	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
25.00	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
25.00	Single	8RWI	StilSwitch2	8RWI-A_2A-StilSwitch2-Na
25.00	Single	8WRZ	PubChem 102336704	8WRZ-CB₁-PubChem 102336704-Arrestin2
25.00	Single	8X8L	Cortistatin	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00	Single	8XJO	U46619	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
25.00	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
25.00	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
25.00	Single	9EAI	Losartan	9EAI-AT₁-Losartan-Nanobody AT209
25.00	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
25.00	Single	9K1D	Butanoic acid	9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
25.00	Single	9KPD	SA0	9KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
25.00	Single	9M2F	Neuropeptide FF	9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
25.00	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
25.00	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
25.00	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
25.00	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
25.00	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
25.00	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
25.00	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
25.00	Consensus	hca_on	Orthosteric Ligand	hca2_on
25.00	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
25.00	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
25.00	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
25.00	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
25.00	Consensus	tp_on	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
24.14	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
24.00	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
24.00	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
24.00	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
24.00	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
24.00	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
24.00	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
24.00	Single	9JFY	hNPSF	9JFY-NPFF2-hNPSF-Gi1/β1/γ2
24.00	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
24.00	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.81	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
23.81	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
23.81	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
23.81	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
23.81	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
23.81	Single	9IPY	JR14a	9IPY-C3a_B-JR14a
23.81	Single	9JF4	PD168368	9JF4-BB₁-PD168368
23.81	Single	9V2N	Macimorelin	9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
23.81	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
23.81	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.81	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
23.53	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
23.53	Single	5UEN	DU172	5UEN-A₁-DU172
23.53	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
23.53	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
23.53	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
23.53	Single	6GPS	MK0812	6GPS-CCR2-MK0812
23.53	Single	6IIV	Daltroban	6IIV-TXA2-Daltroban
23.53	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2
23.53	Single	6LPJ	ZM-241385	6LPJ-A_2A-ZM-241385-Na
23.53	Single	6LPK	ZM-241385	6LPK-A_2A-ZM-241385-Na
23.53	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
23.53	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
23.53	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
23.53	Single	7V3Z	CP55940	7V3Z-CB₁-CP55940
23.53	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
23.53	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
23.53	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
23.53	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
23.53	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/β1/γ2
23.53	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
23.53	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
23.53	Single	8RW7	StilSwitch1	8RW7-A_2A-StilSwitch1-Na
23.53	Single	8RWX	StilSwitch3	8RWX-A_2A-StilSwitch3-Na
23.53	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
23.53	Single	9JGK	Balovaptan	9JGK-5-HT_2B-Balovaptan
23.53	Consensus	cck_off	Orthosteric Ligand	ccka_off
23.53	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
23.53	Consensus	ccr2_off	Orthosteric Ligand	6GPS-CCR2-MK0812
23.53	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
23.53	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
23.53	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
23.53	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
23.53	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
23.53	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
23.53	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
23.33	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
23.33	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
23.08	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
23.08	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
23.08	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
23.08	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
23.08	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
23.08	Single	8Y02	Retinal	8Y02-OPN1SW-Retinal-Gi1/β1/γ2
23.08	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
23.08	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
23.08	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
23.08	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
23.08	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
22.73	Single	7QA8	Peptide	7QA8-STE2-Peptide
22.73	Single	7QA8	Peptide	7QA8-STE2-Peptide
22.73	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
22.73	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
22.73	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
22.73	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.73	Single	8WKY	PG-934	8WKY-MC₄-PG-934
22.73	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
22.73	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.73	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
22.73	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
22.73	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
22.73	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.22	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
22.22	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
22.22	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
22.22	Single	6GPX	MK0812	6GPX-CCR2-MK0812
22.22	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
22.22	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
22.22	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
22.22	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
22.22	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
22.22	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
22.22	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
22.22	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
22.22	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
22.22	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
22.22	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
22.22	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
22.22	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
22.22	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
22.22	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
22.22	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
22.22	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
22.22	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
22.22	Single	9CIB	FCH-2296413	9CIB-HCA₂-FCH-2296413
22.22	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
22.22	Single	9GE2	ML184	9GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
22.22	Single	9KPF	SA0	9KPF-TAS2R16-SA0-Gi1/β1/γ2
22.22	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
22.22	Consensus	blt_off	Orthosteric Ligand	blt1_off
22.22	Consensus	dp2_off	Orthosteric Ligand	6D26-DP₂-Fevipiprant
22.22	Consensus	dp_off	Orthosteric Ligand	dp2_off
22.22	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
22.22	Consensus	fpr1-alx_on_gp	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
22.22	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
22.22	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
22.22	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
22.22	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
21.74	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
21.74	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
21.74	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
21.74	Single	9IQV	Muscarinic toxin 3	9IQV-Alpha1A-Muscarinic toxin 3
21.74	Single	9KFI	Relaxin-3	9KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
21.74	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
21.74	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
21.74	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
21.74	Consensus	ghrelin_on	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
21.74	Consensus	ghrelin_on_gp	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
21.74	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
21.74	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
21.43	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
21.43	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
21.43	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
21.43	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
21.43	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
21.43	Single	8EIT	Doconexent	8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
21.43	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
21.43	Single	8Y63	C20:0 Ceramide	8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
21.43	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
21.05	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
21.05	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
21.05	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
21.05	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
21.05	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
21.05	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
21.05	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
21.05	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
21.05	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
21.05	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/β1/γ2
21.05	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
21.05	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
21.05	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Single	8JSR	Anamorelin	8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
21.05	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
21.05	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.05	Single	9EGO	YVF	9EGO-CB₁-YVF-Gi1/β1/γ2
21.05	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
21.05	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
21.05	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.05	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
21.05	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
21.05	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
21.05	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
21.05	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
20.83	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
20.83	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
20.83	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
20.83	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
20.83	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
20.83	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
20.83	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
20.83	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.83	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.83	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
20.69	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
20.00	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
20.00	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
20.00	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
20.00	Single	6IIU	Ramatroban	6IIU-TXA2-Ramatroban
20.00	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
20.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
20.00	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.00	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
20.00	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.00	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
20.00	Single	7XP6	Strychnine	7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
20.00	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
20.00	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
20.00	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
20.00	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
20.00	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
20.00	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
20.00	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
20.00	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
20.00	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
20.00	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
20.00	Single	8JPN	Cis-Epoxysuccinic acid	8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
20.00	Single	8RWH	StilSwitch2	8RWH-A_2A-StilSwitch2-Na
20.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
20.00	Single	8WP1	Cis-Epoxysuccinic acid	8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
20.00	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00	Single	8X2K	Oleic monoethanolamide	8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
20.00	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00	Single	9B9Y	7DY	9B9Y-CB₁-7DY
20.00	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
20.00	Single	9IZD	CHBA	9IZD-HCA₁-CHBA-Gi1/β1/γ2
20.00	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
20.00	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
20.00	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
20.00	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
19.35	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
19.23	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
19.23	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
19.23	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
19.23	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
19.23	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
19.23	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
19.23	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.05	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
19.05	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
19.05	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
19.05	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/β1/γ2
19.05	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
19.05	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
19.05	Single	9GG5	U46619	9GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05	Single	9M1H	Prostaglandin E2	9M1H-EP₁-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
19.05	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
19.05	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
19.05	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75	Single	3PWH	ZM-241385	3PWH-A_2A-ZM-241385
18.75	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
18.75	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
18.75	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
18.75	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
18.75	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
18.75	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
18.75	Single	8RVW	StilSwitch3	8RVW-A_2A-StilSwitch3-Na
18.75	Single	8RW4	AzoSwitch2	8RW4-A_2A-AzoSwitch2-Na
18.75	Single	8RWE	StilSwitch4	8RWE-A_2A-StilSwitch4-Na
18.75	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
18.75	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
18.75	Single	9FUP	Istradefylline	9FUP-A_2A-Istradefylline-Na
18.75	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
18.75	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
18.52	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
18.52	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.52	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
18.52	Single	9BLW	Cagrilintide backbone (non-acylated)	9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
18.52	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
18.18	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
18.18	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.18	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
18.18	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
18.18	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/β1/γ2
18.18	Single	9IZA	SCH900271	9IZA-HCA₂-SCH900271-Gi1/β1/γ2
18.18	Single	9JH6	C20:0 Ceramide	9JH6-CysLT₂-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
17.86	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
17.86	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
17.86	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.86	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
17.86	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
17.86	Single	8W8W	Alpha-MSH	8W8W-MC₃-α-MSH-Ca-Gs/β1/γ2
17.86	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
17.86	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
17.86	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
17.65	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
17.65	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2
17.65	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
17.65	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
17.65	Single	8JEI	3-nitro-4-(propylamino)benzoic acid	8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
17.65	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
17.65	Single	8K4S	DCA-3P	8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65	Single	8Y6Y	GLPG0974	8Y6Y-FFA2-GLPG0974
17.65	Single	8YKV	PubChem 137553168	8YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
17.65	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070
17.65	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100
17.65	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
17.65	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65	Single	9JMD	Azithromycin	9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
17.65	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
17.65	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
17.65	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.65	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.65	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
17.39	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
17.39	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
17.39	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
17.39	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
17.39	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
17.39	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
17.39	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
17.39	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
17.39	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
17.39	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
17.39	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
17.39	Single	9HB3	Mambaquaretin-1	9HB3-V₂-Mambaquaretin-1
17.39	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
17.39	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
17.39	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
17.24	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
17.24	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
17.24	Single	8KGG	LPS	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.24	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
16.67	Single	6D27	CAY10471	6D27-DP₂-CAY10471
16.67	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
16.67	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
16.67	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
16.67	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
16.67	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.67	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
16.67	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
16.67	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
16.67	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
16.67	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
16.67	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/β1/γ2
16.67	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
16.67	Single	8KEX	DCA-3P	8KEX-MRGPRX4-DCA-3P
16.67	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/β1/γ2
16.67	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
16.67	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
16.67	Single	8XBG	S3E-LysoPS	8XBG-GPR34-S3E-LysoPS
16.67	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
16.67	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
16.67	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
16.67	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
16.67	Single	8ZQE	GPR15L(C11)	8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
16.67	Single	9E82	SDF-1-beta	9E82-ACKR3-SDF-1-β-Arrestin2
16.67	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
16.67	Single	9IQR	Muscarinic toxin 3	9IQR-α_2a-Muscarinic toxin 3
16.67	Single	9IYA	ONO-9710531	9IYA-GPR55-ONO-9710531
16.67	Single	9IZC	MK1903	9IZC-HCA₂-MK1903-Gi1/β1/γ2
16.67	Consensus	alicarboxylic_off	Orthosteric Ligand	succinate_off
16.67	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.67	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
16.67	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
16.67	Consensus	crf1_on	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
16.67	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
16.67	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
16.67	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
16.67	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
16.67	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
16.67	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
16.13	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
16.13	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
16.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.00	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
16.00	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/β1/γ2
16.00	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
16.00	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
16.00	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
16.00	Single	8W8Y	Gamma-MSH	8W8Y-MC₃-γ-MSH-Ca-Gs/β1/γ2
16.00	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.00	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
16.00	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
15.79	Single	5T1A	BMS-681	5T1A-CCR2-BMS-681-PubChem 12093170
15.79	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
15.79	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
15.79	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
15.79	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
15.79	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.79	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.79	Single	8WGB	VU0155041	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
15.79	Single	8ZVZ	BW245C	8ZVZ-DP₁-BW245C-Gs/β1/γ2
15.79	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
15.79	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79	Single	9IYB	Prostaglandin	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
15.79	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
15.79	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
15.79	Consensus	ep_off	Orthosteric Ligand	ep4_off
15.79	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.79	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.79	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
15.62	Consensus	crf1_on_gp	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
15.38	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.38	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
15.38	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
15.38	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
15.38	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
15.38	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
15.38	Single	9BLC	Cagrilintide backbone (non-acylated)	9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
15.38	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
15.38	Consensus	mc5_on_gp	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.38	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
15.38	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
15.15	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
15.00	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
15.00	Single	7T9N	DPPC	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
15.00	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
15.00	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
15.00	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
15.00	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.00	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
15.00	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.00	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
15.00	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
15.00	Single	8ZW0	PGD2	8ZW0-DP₁-PGD2-Gs/β1/γ2
15.00	Single	9CLW	TUG-1375	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00	Single	9UY3	Anamorelin	9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.00	Consensus	nk2_on_gp	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
15.00	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
14.81	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
14.81	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
14.81	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
14.81	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
14.81	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
14.81	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
14.81	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
14.81	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
14.71	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
14.29	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
14.29	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
14.29	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
14.29	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
14.29	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
14.29	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
14.29	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
14.29	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
14.29	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
14.29	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
14.29	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
14.29	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
14.29	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
14.29	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2
14.29	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
14.29	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
14.29	Single	8Y6W	TUG-1375	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
14.29	Single	9AU0	BW245C	9AU0-DP₁-BW245C-Gs/β1/γ2
14.29	Single	9BJK	NAM	9BJK-μ-Naloxone-NAM
14.29	Single	9BLB	Cagrilintide backbone (non-acylated)	9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
14.29	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
14.29	Single	9CM3	TUG-1375	9CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
14.29	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.29	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
14.29	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
13.89	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
13.89	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
13.89	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
13.79	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
13.79	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
13.79	Single	8W8X	Beta-MSH	8W8X-MC₃-β-MSH-Ca-Gs/β1/γ2
13.79	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
13.79	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
13.79	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.64	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
13.64	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
13.64	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
13.64	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
13.64	Single	8XBE	S3E-LysoPS	8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
13.64	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
13.64	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
13.64	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
13.33	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
13.33	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
13.33	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
13.33	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
13.33	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
13.33	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
13.33	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
13.33	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
13.33	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
13.33	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
13.33	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
13.33	Single	8X9U	Metenolone	8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
13.33	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
13.33	Single	9JHJ	C18:0 Ceramide	9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
13.33	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.33	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
13.33	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
13.16	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
13.16	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
13.04	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
13.04	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
13.04	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
13.04	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
13.04	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
13.04	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
13.04	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.04	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
13.04	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
13.04	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
13.04	Single	9CM7	TUG-1375	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
13.04	Single	9NS9	TUG-1375	9NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
13.04	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
12.90	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.50	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
12.50	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
12.50	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
12.50	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
12.50	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
12.50	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	7XKF	Beta-Hydroxyandrosterone	7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
12.50	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.50	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
12.50	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
12.50	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
12.50	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab
12.50	Single	8YKD	Dehydroepiandrosterone	8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
12.50	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
12.50	Single	8ZX5	AM251	8ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
12.50	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.50	Single	9J0I	UDP-Glucuronic acid	9J0I-P2Y₁₄-UDP-Glucuronic acid-Gi1/β1/γ2
12.50	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
12.50	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
12.12	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.12	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
12.12	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
12.12	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
12.00	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
12.00	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
12.00	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
12.00	Single	9IQS	Muscarinic toxin 3	9IQS-M₄-Muscarinic toxin 3
12.00	Single	9J0F	NADH	9J0F-P2Y₁₄-NADH-Gi1/β1/γ2
12.00	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
11.76	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
11.76	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.76	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
11.76	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
11.76	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
11.76	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.76	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
11.76	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/β1/γ2
11.76	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
11.76	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
11.76	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
11.76	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
11.76	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
11.76	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Gi1/β1/γ2
11.76	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
11.76	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
11.76	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491
11.76	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
11.54	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
11.54	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
11.54	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
11.54	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
11.54	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.54	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.54	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
11.54	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
11.43	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.43	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
11.11	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
11.11	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11	Single	7UTZ	DPPC	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
11.11	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
11.11	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
11.11	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
11.11	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
11.11	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
11.11	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
11.11	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
11.11	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
11.11	Single	9IXX	LTD4	9IXX-CysLT₂-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
11.11	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
11.11	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
11.11	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
11.11	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
10.71	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
10.71	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
10.71	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.71	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
10.71	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
10.71	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
10.71	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
10.71	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
10.71	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
10.71	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
10.71	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
10.71	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
10.71	Consensus	pac_on	Orthosteric Ligand	pac1_on
10.71	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
10.53	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
10.53	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
10.53	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
10.34	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
10.34	Single	6FJ3	PTH	6FJ3-PTH1-PTH
10.34	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.34	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
10.34	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
10.34	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
10.34	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
10.34	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
10.34	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
10.34	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
10.34	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
10.34	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
10.34	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
10.34	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
10.34	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.34	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
10.34	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
10.34	Consensus	secretin_on	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
10.34	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
10.00	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
10.00	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
10.00	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
10.00	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
10.00	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
10.00	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
10.00	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
10.00	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
10.00	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
10.00	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
10.00	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
10.00	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00	Consensus	secretin_on_gp	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
9.68	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.68	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.68	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
9.68	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
9.68	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
9.68	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
9.68	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
9.52	Single	5TZR	MK8666	5TZR-FFA1-MK8666
9.52	Single	5V56	TC114	5V56-SMO-TC114
9.52	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.52	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
9.52	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
9.52	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.52	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
9.09	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
9.09	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
9.09	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
9.09	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
9.09	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
9.09	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
9.09	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
9.09	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
9.09	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
8.82	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.82	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
8.82	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
8.70	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
8.70	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
8.70	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
8.70	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
8.70	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
8.70	Single	9JH5	C16:0 Ceramide	9JH5-CysLT₂-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
8.33	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
8.33	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
8.33	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33	Single	8XQJ	JN241	8XQJ-Apelin-JN241
8.33	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
8.33	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.11	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.00	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
8.00	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.00	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
8.00	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
7.69	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
7.69	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
7.69	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
7.69	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
7.69	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
7.69	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
7.69	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
7.41	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
7.41	Single	9B5Y	Long-Acting PTH	9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
7.41	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
7.41	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
7.41	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
7.41	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
7.14	Single	7V68	LY2119620	7V68-M₄-Iperoxo-LY2119620-Gi1/β1/γ2
7.14	Single	7XKE	Beta-Hydroxyandrosterone	7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
6.90	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
6.90	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.90	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.90	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
6.67	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.67	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
6.67	Single	7VDM	Substance-P	7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.67	Single	7Y14	Beta-Alanine	7Y14-MRGPRD-β-Alanine
6.67	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.67	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
6.67	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.45	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
6.45	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
6.45	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.45	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
6.45	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
6.25	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
6.25	Single	7Y12	Beta-Alanine	7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
6.25	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
6.25	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
6.25	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.25	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
6.25	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
6.06	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
6.06	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
6.06	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
5.88	Single	6LI0	C17	6LI0-GPR52-C17
5.88	Single	7S8N	R-Zinc-3573	7S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	7S8O	R-Zinc-3573	7S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.88	Single	7T96	LY2119620	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
5.88	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
5.88	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
5.88	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
5.88	Single	9LMP	NE52-QQ57	9LMP-GPR4-NE52-QQ57
5.88	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg4_on
5.88	Consensus	adgrg_on_gp	Orthosteric Ligand	adgrg2_on_gp adgrg4_on_gp
5.56	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
5.56	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
5.56	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
5.56	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
5.56	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
5.56	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.56	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.56	Single	8T3V	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.26	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
5.26	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
5.26	Single	7T94	LY2119620	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
5.26	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
5.26	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.26	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8IYX	YL-365	8IYX-GPR34-YL-365
5.26	Single	8JD6	VU0364770	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.26	Single	9JFU	NE52-QQ57	9JFU-GPR4-NE52-QQ57
5.26	Single	9K0K	UTP	9K0K-P2Y₄-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9K0X	ATP	9K0X-P2Y₂-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9K20	ATP	9K20-P2Y₂-ATP-chim(NtGi1-Go)/β1/γ2
5.26	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
5.26	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
5.00	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
5.00	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.00	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
5.00	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
5.00	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.00	Single	8ZYY	Neurotensin peptide 8-13	8ZYY-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
5.00	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.76	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
4.76	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
4.76	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
4.76	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.76	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.76	Single	8ZYT	Neurotensin peptide 8-13	8ZYT-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
4.76	Consensus	adgrg2_on	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.76	Consensus	adgrg2_on_gp	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.55	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
4.55	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
4.55	Single	5V57	TC114	5V57-SMO-TC114
4.55	Single	6OS1	TRV026	6OS1-AT₁-TRV026
4.55	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
4.55	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
4.55	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
4.55	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
4.55	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
4.55	Single	8JD5	JNJ-40411813; ADX88178	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.55	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
4.55	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
4.55	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
4.55	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
4.35	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
4.35	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
4.35	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
4.35	Single	6OS2	TRV026	6OS2-AT₁-TRV026
4.35	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
4.35	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
4.35	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
4.35	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
4.35	Single	8XQJ	JN241	8XQJ-Apelin-JN241
4.35	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.35	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
4.35	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
4.35	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
4.17	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
4.17	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
4.17	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
4.17	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
4.17	Single	8FN0	Neurotensin/Neuromedin-N	8FN0-NTS₁-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
4.17	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-SBI-553
4.17	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
4.17	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
4.17	Single	8ZPL	HF51116	8ZPL-CXCR4-HF51116
4.00	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
4.00	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
4.00	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
4.00	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.00	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.00	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
4.00	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
3.85	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
3.85	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
3.85	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
3.85	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.85	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
3.85	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
3.70	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.70	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.57	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.45	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/β1/γ2

PDB Summary
PDB	8THL
Class	A
SubFamily	Amine
Type	Adrenergic
SubType	Alpha1A
Species	Homo Sapiens
Ligand	Epinephrine
Other Ligand(s)	-
Protein Partners	chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2
PDB Resolution	3.1
Date	2023-08-16
D.O.I.	doi.org/10.1038/s41467-023-40524-2

Net Summary
I_min	3.49
Number of Linked Nodes	806
Number of Links	922
Number of Hubs	130
Number of Links mediated by Hubs	488
Number of Communities	28
Number of Nodes involved in Communities	184
Number of Links involved in Communities	246

Path Summary
Number Of Nodes in MetaPath	109
Number Of Links MetaPath	108
Number of Shortest Paths	1250336
Length Of Smallest Path	3
Average Path Length	39.457
Length of Longest Path	76
Minimum Path Strength	1.33
Average Path Strength	7.08335
Maximum Path Strength	29.155
Minimum Path Correlation	0.7
Average Path Correlation	0.977544
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	1.69492
Average % Of Corr. Nodes	36.7117
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.8165
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • protein heterodimerization activity • protein binding • binding • protein dimerization activity • alpha1-adrenergic receptor activity • alpha-adrenergic receptor activity • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • adrenergic receptor activity • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process
Gene Ontology	Biological Process	• defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • cellular process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • response to chemical • response to xenobiotic stimulus • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • signaling • cell-cell signaling • neuron-glial cell signaling • cell communication • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of tube diameter • multicellular organismal process • system process • regulation of tube size • regulation of system process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • heart process • negative regulation of heart rate • regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback • regulation of heart contraction • negative regulation of biological process • negative regulation of blood pressure • negative regulation of systemic arterial blood pressure • nervous system process involved in regulation of systemic arterial blood pressure • regulation of heart rate • nervous system process • regulation of blood pressure • regulation of systemic arterial blood pressure by baroreceptor feedback • negative regulation of blood circulation • negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure • baroreceptor response to increased systemic arterial blood pressure • negative regulation of heart contraction • regulation of systemic arterial blood pressure • heart contraction • negative regulation of multicellular organismal process • phospholipase C-activating G protein-coupled receptor signaling pathway • phospholipase C-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of systemic arterial blood pressure mediated by a chemical signal • positive regulation of blood pressure • positive regulation of blood circulation • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • positive regulation of blood pressure by epinephrine-norepinephrine • positive regulation of heart rate • positive regulation of heart rate by epinephrine-norepinephrine • positive regulation of heart contraction • reflex • pilomotor reflex • modulation of chemical synaptic transmission • positive regulation of synaptic transmission, GABAergic • synaptic signaling • trans-synaptic signaling • synaptic transmission, GABAergic • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of synaptic transmission, GABAergic • smooth muscle contraction • muscle contraction • muscle system process • apoptotic process • cell death • programmed cell death • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure • regulation of action potential • positive regulation of action potential • action potential • regulation of membrane potential • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • muscle hypertrophy • regulation of muscle adaptation • positive regulation of cardiac muscle hypertrophy • striated muscle hypertrophy • regulation of muscle system process • regulation of cardiac muscle hypertrophy • regulation of muscle hypertrophy • muscle adaptation • positive regulation of muscle hypertrophy • cardiac muscle hypertrophy • negative regulation of catabolic process • negative regulation of metabolic process • autophagy • regulation of catabolic process • regulation of autophagy • negative regulation of autophagy • process utilizing autophagic mechanism • regulation of metabolic process • positive regulation of smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • cellular developmental process • cardiac muscle cell development • developmental growth • cell development • organ growth • muscle cell differentiation • cell growth • striated muscle tissue development • muscle structure development • multicellular organism development • striated muscle cell development • muscle cell development • cell differentiation • anatomical structure development • cardiac cell development • muscle tissue development • cardiac muscle tissue growth • system development • developmental process • heart development • heart growth • developmental cell growth • cardiac muscle tissue development • physiological muscle hypertrophy • growth • animal organ development • cardiac muscle cell differentiation • tissue development • cardiocyte differentiation • circulatory system development • cell growth involved in cardiac muscle cell development • physiological cardiac muscle hypertrophy • striated muscle cell differentiation • regulation of the force of heart contraction by chemical signal • regulation of the force of heart contraction • positive regulation of the force of heart contraction by chemical signal • positive regulation of the force of heart contraction by epinephrine-norepinephrine • adult heart development • response to hormone • response to endogenous stimulus • positive regulation of cardiac muscle contraction • cardiac muscle contraction • striated muscle contraction • positive regulation of striated muscle contraction • regulation of cardiac muscle contraction • regulation of striated muscle contraction • host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system
Gene Ontology	Cellular Component	• host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • organelle • nuclear envelope • organelle membrane • cytoplasm • cytosol • membrane microdomain • cell periphery • membrane raft • plasma membrane raft • plasma membrane • plasma membrane region • caveola • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • G protein activity • D1 dopamine receptor binding • dopamine receptor binding • cyclase regulator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • positive regulation of cell population proliferation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • response to nutrient levels • response to nutrient • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • Wnt signaling pathway • neuropeptide signaling pathway • wound healing • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • glutamate receptor signaling pathway • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • homotypic cell-cell adhesion • platelet aggregation • cell adhesion • cell-cell adhesion • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • positive regulation of catalytic activity • positive regulation of lyase activity • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • somatodendritic compartment • dendrite • dendritic tree • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • cell body • ciliary basal body • Golgi apparatus • cytosolic region • postsynapse • postsynaptic cytosol • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ALE
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ALE
Name	Epinephrine
Synonyms	Adrenaline
Identifier
Formula	C9 H13 N O3
Molecular Weight	183.204
SMILES
PubChem	139148732
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>8THL_Chain_A V S A E D K A A A E R S K M I D K N L R E D G E K A R R T L R L L L L G A D N S G K S T I V K G I F E T K F Q V D K V N F H M F D V G R R K W I Q C F N D V T A I I F V V D S S D Y N R L Q E A L N D F K S I W N N R W L R T I S V I L F L N K Q D L L A E K V L A G K S K I E D Y F P E F A R Y T T P D P R V T R A K Y F I R K E F V D I S T A S G D G R H I C Y P H F T C A V D T E N A R R I F N D C K D I I L Q M N L R E Y N L V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8THL_Chain_B E L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8THL_Chain_G I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P35348
Sequence	>8THL_Chain_R L G G L I L F G V L G N I L V I L S V A C H R H L H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G Y W A F G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y P L R Y P T I V T Q R R G L M A L L C V W A L S L V I S I G P L F G W R Q P A P E D E T I C Q I N E E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E S K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F P D F K P S E T V F K I V F W L G Y L N S C I N P I I Y P C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9M4Q	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Doxazosin	-	-	2.99	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9M4T	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Silodosin	-	-	3.19	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	7YM8	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Oxymetazoline	-	chim(Gs-CtGq)	2.92	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YM8 (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Oxymetazoline	-		2.92	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YMH	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Norepinephrine	-	chim(Gs-CtGq)	3.52	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YMH (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Norepinephrine	-		3.52	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YMJ	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Tamsulosin	-	-	3.35	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	8THK	A	Amine	Adrenergic	Alpha1A	Homo sapiens	A61603	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.6	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8THK (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	A61603	-		2.6	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8THL	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Epinephrine	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.1	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8THL (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Epinephrine	-		3.1	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8HN1	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Toxin AdTx1	-	-	2.9	2023-12-20	To be published
	9IQV	A	Amine	Adrenegic	Alpha1A	Homo sapiens	-	Muscarinic toxin 3	-	3.3	2025-07-23	To be published

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